Distinct requirements of hematopoietic stem cell activity and Nras G12D signaling in different cell types during leukemogenesis

Cell Cycle

Volumn 10, Issue 17, 2011, Pages 2836-2839

  Wang, Jinyong ^a   Liu, Yangang ^a   Tan, Li Xuan ^b   Lo, Juinn Cherng ^b   Du, Juan ^a,b,c   Ryu, Myung Jeom ^a   Ranheim, Erik A ^c   Zhang, Jing ^a  

^a UNIVERSITY OF WISCONSIN MADISON   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c UNIVERSITY OF WISCONSIN   (United States)

Author keywords

BALL; HSCs; Leukemogenesis; MPD; Oncogenic Nras; TALL

Indexed keywords

MEMBRANE PROTEIN; PROTEIN NRAS G12D; UNCLASSIFIED DRUG;

CELL ACTIVITY; CELL LINEAGE; CELL TYPE; CONTROLLED STUDY; HEMATOPOIETIC STEM CELL; LEUKEMOGENESIS; MYELOPROLIFERATIVE DISORDER; NONHUMAN; PHENOTYPE; SHORT SURVEY; SIGNAL TRANSDUCTION;

MUS;

EID: 80052417622     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.10.17.17195     Document Type: Short Survey

References (5)

1. Wang J.Y., Liu Y.G., Li Z.Y., Wang Z.D., Tan L.X., Ryu M.J., et al. Endogenous oncogenic Nras mutation initiates hematopoietic malignancies in a dose- and cell type-dependent manner. Blood 2011; 118:368- 79; PMID:21586752; DOI:10.1182/blood-2010-12- 326058.
2. Kühn R., Schwenk F., Aguet M., Rajewsky K. Inducible gene targeting in mice. Science 1995; 269:1427-9; PMID:7660125; DOI:10.1126/science. 7660125.
3. Chan I.T., Kutok J.L., Williams I.R., Cohen S., Kelly L., Shigematsu H., et al. Conditional expression of oncogenic K-ras from its endogenous promoter induces a myeloproliferative disease. J Clin Invest 2004; 113:528-538; PMID:14966562.
4. Wang J.Y., Liu Y.G., Li Z.Y., Du J., Ryu M.J., Taylor P.R., et al. Endogenous oncogenic Nras mutation leads to aberrant GM-CSF signaling in granulocytic/ monocytic precursors in a murine model of chronic myelomonocytic leukemia. Blood 2010; 116:5991- 6002; PMID:20921338; DOI:10.1182/blood-2010- 04-281527.
5. Zhang J., Wang J., Liu Y., Sidik H., Young K.H., Lodish H.F., et al. Oncogenic Kras-induced leukemogeneis: hematopoietic stem cells as the initial target and lineage-specific progenitors as the potential targets for final leukemic transformation. Blood 2009; 113:1304-14; PMID:19066392; DOI:10.1182/ blood-2008-01-134262.