메뉴 건너뛰기




Volumn 8, Issue 16, 2009, Pages 2518-2522

The Par-4/PTEN connection in tumor suppression

Author keywords

Akt; aPKC; NF B; Par 4; PKC ; Prostate cancer; PTEN; Tumor suppressors

Indexed keywords

CASPASE 3; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; INTERLEUKIN 8; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEINASE ACTIVATED RECEPTOR 4; X LINKED INHIBITOR OF APOPTOSIS;

EID: 69249219273     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.8.16.9384     Document Type: Review
Times cited : (23)

References (47)
  • 2
    • 0035496220 scopus 로고    scopus 로고
    • The development of androgen-independent prostate cancer
    • Feldman BJ, Feldman D. The development of androgen-independent prostate cancer. Nat Rev Cancer 2001; 1:34-45.
    • (2001) Nat Rev Cancer , vol.1 , pp. 34-45
    • Feldman, B.J.1    Feldman, D.2
  • 3
    • 4043181214 scopus 로고    scopus 로고
    • Cancer genes and the pathways they control
    • DOI 10.1038/nm1087
    • Vogelstein B, Kinzler KW. Cancer genes and the pathways they control. Nat Med 2004; 10:789-799 (Pubitemid 39070849)
    • (2004) Nature Medicine , vol.10 , Issue.8 , pp. 789-799
    • Vogelstein, B.1    Kinzler, K.W.2
  • 8
    • 0033551070 scopus 로고    scopus 로고
    • New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
    • Cantley LC, Neel BG. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc Natl Acad Sci USA 1999; 96:4240-4245
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 4240-4245
    • Cantley, L.C.1    Neel, B.G.2
  • 9
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB signaling: Navigating downstream
    • Manning BD, Cantley LC. AKT/PKB signaling: navigating downstream. Cell 2007; 129:1261-1274
    • (2007) Cell , vol.129 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 11
    • 0033200172 scopus 로고    scopus 로고
    • Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage
    • McMenamin ME, Soung P, Perera S, Kaplan I, Loda M, Sellers WR. Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage. Cancer Res 1999; 59:4291-4296 (Pubitemid 29418745)
    • (1999) Cancer Research , vol.59 , Issue.17 , pp. 4291-4296
    • McMenamin, M.E.1    Soung, P.2    Perera, S.3    Kaplan, I.4    Loda, M.5    Sellers, W.R.6
  • 14
    • 0031870959 scopus 로고    scopus 로고
    • Pten is essential for embryonic development and tumour suppression
    • DOI 10.1038/1235
    • Di Cristofano A, Pesce B, Cordon-Cardo C, Pandolfi PP. Pten is essential for embryonic development and tumour suppression. Nat Genet 1998; 19:348-355 (Pubitemid 28357906)
    • (1998) Nature Genetics , vol.19 , Issue.4 , pp. 348-355
    • Di Cristofano, A.1    Pesce, B.2    Cordon-Cardo, C.3    Pandolfi, P.P.4
  • 16
    • 0032532485 scopus 로고    scopus 로고
    • Mapping of the human PAWR (par-4) gene to chromosome 12q21
    • DOI 10.1006/geno.1998.5494
    • Johnstone RW, Tommerup N, Hansen C, Vissing H, Shi Y. Mapping of the human PAWR (par-4) gene to chromosome 12q21. Genomics 1998; 53:241-243 (Pubitemid 28496616)
    • (1998) Genomics , vol.53 , Issue.2 , pp. 241-243
    • Johnstone, R.W.1    Tommerup, N.2    Hansen, C.3    Vissing, H.4    Shi, Y.5
  • 22
    • 0033518129 scopus 로고    scopus 로고
    • Interaction partners of Dlk/ZIP kinase: Co-expression of Dlk/ZIP kinase and Par-4 results in cytoplasmic retention and apoptosis
    • Page G, Kogel D, Rangnekar V, Scheidtmann KH. Interaction partners of Dlk/ZIP kinase: co-expression of Dlk/ZIP kinase and Par-4 results in cytoplasmic retention and apoptosis. Oncogene 1999; 18:7265-7273 (Pubitemid 30032105)
    • (1999) Oncogene , vol.18 , Issue.51 , pp. 7265-7273
    • Page, G.1    Kogel, D.2    Rangnekar, V.3    Scheidtmann, K.H.4
  • 23
    • 0030572696 scopus 로고    scopus 로고
    • The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C
    • DOI 10.1016/S0092-8674(00)80152-X
    • Diaz-Meco MT, Municio MM, Frutos S, Sanchez P, Lozano J, Sanz L, et al. The product of par-4, a gene induced during apoptosis, interacts selectively with the atypical isoforms of protein kinase C. Cell 1996; 86:777-786 (Pubitemid 26303446)
    • (1996) Cell , vol.86 , Issue.5 , pp. 777-786
    • Diaz-Meco, M.T.1    Municio, M.M.2    Frutos, S.3    Sanchez, P.4    Lozano, J.5    Sanz, L.6    Moscat, J.7
  • 24
    • 0034328882 scopus 로고    scopus 로고
    • The atypical protein kinase Cs. Functional specificity mediated by specific protein adapters
    • Moscat J, Diaz-Meco MT. The atypical protein kinase Cs. Functional specificity mediated by specific protein adapters. EMBO Rep 2000; 1:399-403.
    • (2000) EMBO Rep , vol.1 , pp. 399-403
    • Moscat, J.1    Diaz-Meco, M.T.2
  • 25
    • 0037223086 scopus 로고    scopus 로고
    • NF-kappaB activation by protein kinase C isoforms and B-cell function
    • DOI 10.1038/sj.embor.embor704
    • Moscat J, Diaz-Meco MT, Rennert P. NFkappaB activation by protein kinase C isoforms and B-cell function. EMBO Rep 2003; 4:31-36 (Pubitemid 36305374)
    • (2003) EMBO Reports , vol.4 , Issue.1 , pp. 31-36
    • Moscat, J.1    Diaz-Meco, M.T.2    Rennert, P.3
  • 26
    • 0033570912 scopus 로고    scopus 로고
    • The downregulation of the pro-apoptotic protein Par-4 is critical for Ras-induced survival and tumor progression
    • DOI 10.1093/emboj/18.22.6362
    • Barradas M, Monjas A, Diaz-Meco MT, Serrano M, Moscat J. The downregulation of the pro-apoptotic protein Par-4 is critical for Ras-induced survival and tumor progression. EMBO J 1999; 18:6362-6369 (Pubitemid 29533240)
    • (1999) EMBO Journal , vol.18 , Issue.22 , pp. 6362-6369
    • Barradas, M.1    Monjas, A.2    Diaz-Meco, M.T.3    Serrano, M.4    Moscat, J.5
  • 27
    • 0033538336 scopus 로고    scopus 로고
    • Inactivation of the inhibitory kappaB protein kinase/nuclear factor kappaB pathway by Par-4 expression potentiates tumor necrosis factor alpha-induced apoptosis
    • Diaz-Meco MT, Lallena MJ, Monjas A, Frutos S, Moscat J. Inactivation of the inhibitory kappaB protein kinase/nuclear factor kappaB pathway by Par-4 expression potentiates tumor necrosis factor alpha-induced apoptosis. J Biol Chem 1999; 274:19606-19612 (Pubitemid 129519402)
    • (1999) Journal of Biological Chemistry , vol.274 , Issue.28 , pp. 19606-19612
    • Diaz-Meco, M.T.1    Lallena, M.-J.2    Monjas, A.3    Frutos, S.4    Moscat, J.5
  • 29
    • 0242585506 scopus 로고    scopus 로고
    • Genetic inactivation of Par4 results in hyperactivation of NF-κB and impairment of JNK and p38
    • DOI 10.1038/sj.embor.embor769
    • Garcia-Cao I, Lafuente M, Criado L, Diaz-Meco M, Serrano M, Moscat J. Genetic inactivation of Par4 results in hyperactivation of NFκB and impairment of JNK and p38. EMBO Rep 2003; 4:307-312 (Pubitemid 36511729)
    • (2003) EMBO Reports , vol.4 , Issue.3 , pp. 307-312
    • Garcia-Cao, I.1    Lafuente, M.J.2    Criado, L.M.3    Diaz-Meco, M.T.4    Serrano, M.5    Moscat, J.6
  • 30
    • 33745316089 scopus 로고    scopus 로고
    • Identification of a tumour suppressor network opposing nuclear Akt function
    • DOI 10.1038/nature04809, PII NATURE04809
    • Trotman LC, Alimonti A, Scaglioni PP, Koutcher JA, Cordon-Cardo C, Pandolfi PP. Identification of a tumour suppressor network opposing nuclear Akt function. Nature 2006; 441:523-527 (Pubitemid 44050155)
    • (2006) Nature , vol.441 , Issue.7092 , pp. 523-527
    • Trotman, L.C.1    Alimonti, A.2    Scaglioni, P.P.3    Koutcher, J.A.4    Cordon-Cardo, C.5    Pandolfi, P.P.6
  • 32
    • 23744484194 scopus 로고    scopus 로고
    • Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor suppression
    • DOI 10.1101/gad.1314405
    • Ma L, Teruya-Feldstein J, Behrendt N, Chen Z, Noda T, Hino O, et al. Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor suppression. Genes Dev 2005; 19:1779-1786 (Pubitemid 41126917)
    • (2005) Genes and Development , vol.19 , Issue.15 , pp. 1779-1786
    • Ma, L.1    Teruya-Feldstein, J.2    Behrendt, N.3    Chen, Z.4    Noda, T.5    Hino, O.6    Cordon-Cardo, C.7    Pandolfi, P.P.8
  • 33
    • 33745051551 scopus 로고    scopus 로고
    • Ink4c and Pten constrain a positive regulatory loop between cell growth and cell cycle control
    • DOI 10.1128/MCB.00266-06
    • Bai F, Pei XH, Pandolfi PP, Xiong Y. p18 Ink4c and Pten constrain a positive regulatory loop between cell growth and cell cycle control. Mol Cell Biol 2006; 26:4564-4576 (Pubitemid 43877575)
    • (2006) Molecular and Cellular Biology , vol.26 , Issue.12 , pp. 4564-4576
    • Bai, F.1    Pei, X.-H.2    Pandolfi, P.P.3    Xiong, Y.4
  • 35
    • 33646342738 scopus 로고    scopus 로고
    • NKX3.1 stabilizes p53, inhibits AKT activation, and blocks prostate cancer initiation caused by PTEN loss
    • DOI 10.1016/j.ccr.2006.03.031, PII S1535610806001188
    • Lei Q, Jiao J, Xin L, Chang CJ, Wang S, Gao J, et al. NKX3.1 stabilizes p53, inhibits AKT activation, and blocks prostate cancer initiation caused by PTEN loss. Cancer Cell 2006; 9:367-378 (Pubitemid 43668733)
    • (2006) Cancer Cell , vol.9 , Issue.5 , pp. 367-378
    • Lei, Q.1    Jiao, J.2    Xin, L.3    Chang, C.-J.4    Wang, S.5    Gao, J.6    Gleave, M.E.7    Witte, O.N.8    Liu, X.9    Wu, H.10
  • 36
    • 50049125036 scopus 로고    scopus 로고
    • Aberrant Rhebmediated mTORC1 activation and Pten haploinsufficiency are cooperative oncogenic events
    • Nardella C, Chen Z, Salmena L, Carracedo A, Alimonti A, Egia A, et al. Aberrant Rhebmediated mTORC1 activation and Pten haploinsufficiency are cooperative oncogenic events. Genes Dev 2008; 22:2172-2177
    • (2008) Genes Dev , vol.22 , pp. 2172-2177
    • Nardella, C.1    Chen, Z.2    Salmena, L.3    Carracedo, A.4    Alimonti, A.5    Egia, A.6
  • 37
    • 33644513051 scopus 로고    scopus 로고
    • Cooperation between FGF8b overexpression and PTEN deficiency in prostate tumorigenesis
    • DOI 10.1158/0008-5472.CAN-05-3440
    • Zhong C, Saribekyan G, Liao CP, Cohen MB, Roy-Burman P. Cooperation between FGF8b overexpression and PTEN deficiency in prostate tumorigenesis. Cancer Res 2006; 66:2188-2194 (Pubitemid 43294929)
    • (2006) Cancer Research , vol.66 , Issue.4 , pp. 2188-2194
    • Zhong, C.1    Saribekyan, G.2    Liao, C.-P.3    Cohen, M.B.4    Roy-Burman, P.5
  • 38
    • 66749100105 scopus 로고    scopus 로고
    • Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis
    • King JC, Xu J, Wongvipat J, Hieronymus H, Carver BS, Leung DH, et al. Cooperativity of TMPRSS2-ERG with PI3-kinase pathway activation in prostate oncogenesis. Nat Genet 2009; 41:524-526
    • (2009) Nat Genet , vol.41 , pp. 524-526
    • King, J.C.1    Xu, J.2    Wongvipat, J.3    Hieronymus, H.4    Carver, B.S.5    Leung, D.H.6
  • 40
    • 0036710512 scopus 로고    scopus 로고
    • The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network
    • DOI 10.1016/S0968-0004(02)02166-7, PII S0968000402021667
    • Mayo LD, Donner DB. The PTEN, Mdm2, p53 tumor suppressor-oncoprotein network. Trends Biochem Sci 2002; 27:462-467 (Pubitemid 35246255)
    • (2002) Trends in Biochemical Sciences , vol.27 , Issue.9 , pp. 462-467
    • Mayo, L.D.1    Donner, D.B.2
  • 42
    • 31544454967 scopus 로고    scopus 로고
    • PTEN autoregulates its expression by stabilization of p53 in a phosphatase-independent manner
    • DOI 10.1158/0008-5472.CAN-05-1557
    • Tang Y, Eng C. PTEN autoregulates its expression by stabilization of p53 in a phosphatase- independent manner. Cancer Res 2006; 66:736-742 (Pubitemid 43165936)
    • (2006) Cancer Research , vol.66 , Issue.2 , pp. 736-742
    • Tang, Y.1    Eng, C.2
  • 43
    • 33947599080 scopus 로고    scopus 로고
    • A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis
    • DOI 10.1021/pr060504h
    • Flores-Delgado G, Liu CW, Sposto R, Berndt N. A limited screen for protein interactions reveals new roles for protein phosphatase 1 in cell cycle control and apoptosis. J Proteome Res 2007; 6:1165-1175 (Pubitemid 46480481)
    • (2007) Journal of Proteome Research , vol.6 , Issue.3 , pp. 1165-1175
    • Flores-Delgado, G.1    Liu, C.W.Y.2    Sposto, R.3    Berndt, N.4
  • 47
    • 48449092237 scopus 로고    scopus 로고
    • A prostatic intraepithelial neoplasia-dependent p27 Kip1 checkpoint induces senescence and inhibits cell proliferation and cancer progression
    • Majumder PK, Grisanzio C, O'Connell F, Barry M, Brito JM, Xu Q, et al. A prostatic intraepithelial neoplasia-dependent p27 Kip1 checkpoint induces senescence and inhibits cell proliferation and cancer progression. Cancer Cell 2008; 14:146-155
    • (2008) Cancer Cell , vol.14 , pp. 146-155
    • Majumder, P.K.1    Grisanzio, C.2    O'Connell, F.3    Barry, M.4    Brito, J.M.5    Xu, Q.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.