A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK

Nature

Volumn 472, Issue 7343, 2011, Pages 366-369

  Brennan, Damian F ^a   Dar, Arvin C ^b   Hertz, Nicholas T ^b   Chao, William C H ^a   Burlingame, Alma L ^c   Shokat, Kevan M ^b   Barford, David ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; POTASSIUM CHLORIDE; RAF PROTEIN;

CANCER; CATALYSIS; ENZYME ACTIVITY; GENE EXPRESSION; PROTEIN;

ALLOSTERISM; ARTICLE; BIOCHEMISTRY; CATALYSIS; CHEMICAL GENETICS; CHEMICAL STRUCTURE; CRYSTAL STRUCTURE; GENETIC SCREENING; LIMBIC CORTEX; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; SIGNAL TRANSDUCTION;

ADENOSINE TRIPHOSPHATE; ALLOSTERIC REGULATION; ANIMALS; BIOCATALYSIS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; MAP KINASE KINASE 1; MODELS, MOLECULAR; PHOSPHORYLATION; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, QUATERNARY; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS B-RAF; RABBITS; SIGNAL TRANSDUCTION;

METAZOA; ORYCTOLAGUS CUNICULUS;

EID: 79955472800     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature09860     Document Type: Article

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