Human colon cancer stem cells are enriched by insulin-like growth factor-1 and are sensitive to figitumumab

Cell Cycle

Volumn 10, Issue 14, 2011, Pages 2331-2338

  Hart, Lori S ^a   Dolloff, Nathan G ^b   Dicker, David T ^b   Koumenis, Constantinos ^a   Christensen, James G ^d   Grimberg, Adda ^c   El Deiry, Wafik S ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b PENN STATE MILTON S HERSHEY MEDICAL CENTER   (United States)

^c CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^d PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Cancer stem cell; Colon cancer; Figitumumab; IGF 1

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; ALDEHYDE DEHYDROGENASE; BETA CATENIN; CELL ANTIGEN; FIGITUMUMAB; FUMITREMORGIN C; LITHIUM CHLORIDE; MITOXANTRONE; PEROXIDASE; PROTEIN KINASE B; SOMATOMEDIN C; VERAPAMIL;

ANIMAL EXPERIMENT; ANTIGEN EXPRESSION; ARTICLE; CANCER GROWTH; CANCER STEM CELL; CARCINOGENICITY; CHEMOLUMINESCENCE; COLON CANCER; DRUG SENSITIVITY; ENZYME ACTIVITY; FLOW CYTOMETRY; GENE OVEREXPRESSION; HUMAN; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR GROWTH;

EID: 79960438373     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.10.14.16418     Document Type: Article

References (44)

1. Hadnagy A, Gaboury L, Beaulieu R, Balicki D. SP analysis may be used to identify cancer stem cell populations. Exp Cell Res 2006; 312:3701-10. (Pubitemid 44633895)
2. Hirschmann-Jax C, Foster AE, Wulf GG, Nuchtern JG, Jax TW, Gobel U, et al. A distinct "side population" of cells with high drug efflux capacity in human tumor cells. PNAS 2004; 101:14228-33.
3. Huang EH, Hynes MJ, Zhang T, Ginestier C, Dontu G, Appelman H, et al. Aldehyde Dehydrogenase 1 Is a Marker for Normal and Malignant Human Colonic Stem Cells (SC) and Tracks SC Overpopulation during Colon Tumorigenesis. Cancer Research 2009; 69:3382-9.
4. Hosen N, Park C, Tatsumi N, Oji Y, Sugiyama H, Gramatzki M, et al. CD96 is a leukemic stem cell-specific marker in human acute myeloid leukemia. Proc Natl Acad Sci 2007; 104:11008-13. (Pubitemid 47175217)
5. Al-Hajj M, Wicha M, Benito-Hernandez A, Morrison S, Clarke M. Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci 2003; 100:3983-8. (Pubitemid 36418143)
6. Wulf GG, Wang RY, Kuehnle I, Weidner D, Marini F, Brenner MK, et al. A leukemic stem cell with intrinsic drug efflux capacity in acute myeloid leukemia. Blood 2001; 98:1166-73.
7. Singh SK, Hawkins C, Clarke ID, Squire JA, Bayani J, Hide T, et al. Identification of human brain tumor initiating cells. Nature 2004; 432:396-401. (Pubitemid 39551674)
8. O'Brien CA, Pollett A, Gallinger S, Dick JE. A human colon cancer cell capable of initiating tumor growth in immunodeficient mice. Nature 2007; 445:106-10. (Pubitemid 46067310)
9. Ishigami S, Ueno S, Arigami T, Uchikado Y, Setoyama T, Arima H, et al. Prognostic Impact of CD133 Expression in Gastric Carcinoma. Anticancer Research 2010; 30:2453-7.
10. Kemper K, Sprick MR, de Bree M, Scopelliti A, Vermeulen L, Hoek M, et al. The AC133 Epitope, but not the CD133 Protein, Is Lost upon Cancer Stem Cell Differentiation. Cancer Research 2010; 70:719-29.
11. Ricci-Vitiani L, Lombardi DG, Pilozzi E, Biffoni M, Todaro M, Peschle C, et al. Identification and expansion of human colon-cancer-initiating cells. Nature 2007; 445:111-5. (Pubitemid 46067311)
12. - metastatic colon cancer cells initiate tumors. J Clin Invest 2008; 118:2111-20.
13. Vermeulen L, Todaro M, de Sousa Mello F, Sprick MR, Kemper K, Perez Alea M, et al. Single-cell cloning of colon cancer stem cells reveals a multi-lineage differentiation capacity. Proceedings of the National Academy of Sciences 2008; 105:13427-32.
14. Gires O, Klein CA, Baeuerle PA. On the abundance of EpCAM on cancer stem cells. Nature Reviews Cancer 2009; 9:143.
15. Kanwar S, Yu Y, Nautiyal J, Patel B, Majumdar A. The Wnt/beta-catenin pathway regulates growth and maintenance of colonospheres. Molecular Cancer 2010; 9:212.
16. + Cancer Stem Cells with Metastatic Capacity in Human Colorectal Cancer. Cell Stem Cell 2010; 6:603-15.
17. Barker N, van Es JH, Kuipers J, Kujala P, van den Born M, Cozijnsen M, et al. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 2007; 449:1003-7. (Pubitemid 350014593)
18. Dalerba P, Dylla SJ, Park, IK, Liu R, Wang X, Cho RW, et al. Phenotypic characterization of human colorectal cancer stem cells. Proceedings of the National Academy of Sciences 2007; 104:10158-63. (Pubitemid 47175279)
19. Carpentino JE, Hynes MJ, Appelman HD, Zheng T, Steindler DA, Scott EW, et al. Aldehyde Dehydrogenase Expressing Colon Stem Cells Contribute to Tumorigenesis in the Transition from Colitis to Cancer. Cancer Research 2009; 69:8208-15.
20. Ho MM, Ng AV, Lam S, Hung JY. Side Population in Human Lung Cancer Cell Lines and Tumors Is Enriched with Stem-like Cancer Cells. Cancer Res 2007; 67:4827-33. (Pubitemid 46910191)
21. Chu P, Clanton DJ, Snipas TS, Lee J, Mitchell E, Nguyen, ML, et al. Characterization of a subpopulation of colon cancer cells with stem cell-like properties. International Journal of Cancer 2009; 124:1312-21.
22. Goodell M, McKinney-Freeman S, Camargo F. Isolation and characterization of side population cells. Methods Mol Biol 2005; 290:343-52.
23. - Cancer Cells Are Similarly Tumorigenic. Cancer Res 2005; 65:6207-19.
24. Tavaluc R, Hart L, Dicker D, El-Deiry W. Effects of low confluency, serum starvation and hypoxia on the side population of cancer cell lines. Cell Cycle 2007; 6:2554-62. (Pubitemid 350058675)
25. Sussman R, Ricci M, Hart L, Sun S, El-Deiry W. Chemotherapy-resistant side-population of colon cancer cells has a higher sensitivity to TRAIL than the non-SP, a higher expression of c-Myc and TRAIL-receptor DR4. Cancer Biol Ther 2007; 6:1490-5. (Pubitemid 351590363)
26. Charafe-Jauffret E, Ginestier C, Iovino F, Tarpin C, Diebel M, Esterni B, et al. Aldehyde Dehydrogenase 1-Positive Cancer Stem Cells Mediate Metastasis and Poor Clinical Outcome in Inflammatory Breast Cancer. Clinical Cancer Research 2010; 16:45-55.
27. Ginestier C, Hur MH, Charafe-Jauffret E, Monville F, Dutcher J, Brown M, et al. ALDH1 Is a Marker of Normal and Malignant Human Mammary Stem Cells and a Predictor of Poor Clinical Outcome. Cell Stem Cell 2007; 1:555-67. (Pubitemid 350056407)
28. Ouban A, Muraca P, Yeatman T, Coppola D. Expression and distribution of insulin-like growth factor-1 receptor in human carcinomas. Human Pathology 2003; 34:803-8. (Pubitemid 37040618)
29. Weber MM, Fottner C, Liu SB, Jung MC, Engelhardt D, Baretton GB. Overexpression of the insulin-like growth factor I receptor in human colon carcinomas. Cancer 2002; 95:2086-95. (Pubitemid 35253369)
30. Manning BD, Cantley LC. AKT/PKB Signaling: Navigating Downstream. Cell 2007; 129:1261-74. (Pubitemid 46962095)
31. Giovannucci E. Insulin, Insulin-Like Growth Factors and Colon Cancer: A Review of the Evidence. Journal of Nutrition 2001; 131:3109-20.
32. Wolpin BM, Meyerhardt JA, Chan AT, Ng K, Chan JA, Wu K, et al. Insulin, the Insulin-Like Growth Factor Axis and Mortality in Patients With Nonmetastatic Colorectal Cancer. Journal of Clinical Oncology 2009; 27:176-85.
33. Jenkins PJ, Fairclough PD, Richards T, Lowe DG, Monson J, Grossman A, et al. Acromegaly, colonic polyps and carcinoma. Clinical Endocrinology 1997; 47:17-22. (Pubitemid 27313983)
34. Dallas NA, Xia L, Fan F, Gray MJ, Gaur P, van Buren G, et al. Chemoresistant Colorectal Cancer Cells, the Cancer Stem Cell Phenotype and Increased Sensitivity to Insulin-like Growth Factor-I Receptor Inhibition. Cancer Research 2009; 69:1951-7.
35. Grimberg A. Mechanisms by which IGF-1 may promote cancer. Cancer Biology & Therapy 2003; 2:630-5.
36. Wu Y, Yakar S, Zhao L, Hennighausen L, LeRoith D. Circulating Insulin-like Growth Factor-I Levels Regulate Colon Cancer Growth and Metastasis. Cancer Research 2002; 62:1030-5.
37. Bleau AM, Hambardzumyan D, Ozawa T, Fomchenko EI, Huse JT, Brennan CW, et al. PTEN/PI3K/Akt Pathway Regulates the Side Population Phenotype and ABCG2 Activity in Glioma Tumor Stem-like Cells. Cell Stem Cell 2009; 4:226-35.
38. Fukuda R, Hirota K, Fan F, Jung YD, Ellis LM, Semenza GL. Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol-3-kinase signaling in colon cancer cells. J Biol Chem 2002; 277:38205-11. (Pubitemid 35154674)
39. Bustin SA, Dorudi S, Phillips SM, Feakins RMJPJ. Local expression of insulin-like growth factor-I affects angiogenesis in colorectal cancer. Tumor Biol 2002; 23:130-8. (Pubitemid 44858304)
40. Reinmuth N, Fan F, Liu W, Parikh AA, Stoeltzing O, Jung YD, et al. Impact of insulin-like growth factor receptor-I function on angiogenesis, growth and metastasis of colon cancer. Lab Invest 2002; 82:1377-89. (Pubitemid 35191541)
41. Kurmasheva RT, Dudkin L, Billups C, Debelenko LV, Morton CL, Houghton PJ. The Insulin-like Growth Factor-1 Receptor-Targeting Antibody, CP-751,871, Suppresses Tumor-Derived VEGF and Synergizes with Rapamycin in Models of Childhood Sarcoma. Cancer Research 2009; 69:7662-71.
42. Morin PJ, Sparks AB, Korinek V, Barker N, Clevers H, Vogelstein B, et al. Activation of beta-Catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science 1997; 275:1787-90. (Pubitemid 27136715)
43. Vermeulen L, De Sousa E, Melo F, van der Heijden M, Cameron K, de Jong JH, et al. Wnt activity defines colon cancer stem cells and is regulated by the microenvironment. Nat Cell Biol 2010; 12:468-76.
44. Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, et al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 2007; 131:861-72. (Pubitemid 350138099)