-
1
-
-
34249284512
-
mTOR at the crossroads of T cell proliferation and tolerance
-
Mondino A, Mueller DL. mTOR at the crossroads of T cell proliferation and tolerance. Semin Immunol 2007; 19:4-6.
-
(2007)
Semin Immunol
, vol.19
, pp. 4-6
-
-
Mondino, A.1
Mueller, D.L.2
-
3
-
-
65449135649
-
The multiple facets of mTOR in immunity
-
Weichhart T, Saemann MD. The multiple facets of mTOR in immunity. Trends Immunol 2009; 30:218-26.
-
(2009)
Trends Immunol
, vol.30
, pp. 218-226
-
-
Weichhart, T.1
Saemann, M.D.2
-
4
-
-
0037623417
-
GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR
-
Kim DH, Sarbassov DD, Ali SM, Latek RR, Guntur KV, Erdjument-Bromage H, et al. GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Mol Cell 2003; 11:895-904.
-
(2003)
Mol Cell
, vol.11
, pp. 895-904
-
-
Kim, D.H.1
Sarbassov, D.D.2
Ali, S.M.3
Latek, R.R.4
Guntur, K.V.5
Erdjument-Bromage, H.6
-
5
-
-
0037178786
-
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
-
Kim DH, Sarbassov DD, Ali SM, King JE, Latek RR, Erdjument-Bromage H, et al. mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 2002; 110:163-75.
-
(2002)
Cell
, vol.110
, pp. 163-175
-
-
Kim, D.H.1
Sarbassov, D.D.2
Ali, S.M.3
King, J.E.4
Latek, R.R.5
Erdjument-Bromage, H.6
-
6
-
-
0037178781
-
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
-
Hara K, Maruki Y, Long X, Yoshino K, Oshiro N, Hidayat S, et al. Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell 2002; 110:177-89.
-
(2002)
Cell
, vol.110
, pp. 177-189
-
-
Hara, K.1
Maruki, Y.2
Long, X.3
Yoshino, K.4
Oshiro, N.5
Hidayat, S.6
-
7
-
-
33947264077
-
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
-
Sancak Y, Thoreen CC, Peterson TR, Lindquist RA, Kang SA, Spooner E, et al. PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase. Mol Cell 2007; 25:903-15.
-
(2007)
Mol Cell
, vol.25
, pp. 903-915
-
-
Sancak, Y.1
Thoreen, C.C.2
Peterson, T.R.3
Lindquist, R.A.4
Kang, S.A.5
Spooner, E.6
-
8
-
-
67349241955
-
DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival
-
Peterson TR, Laplante M, Thoreen CC, Sancak Y, Kang SA, Kuehl WM, et al. DEPTOR is an mTOR inhibitor frequently overexpressed in multiple myeloma cells and required for their survival. Cell 2009; 137:873-86.
-
(2009)
Cell
, vol.137
, pp. 873-886
-
-
Peterson, T.R.1
Laplante, M.2
Thoreen, C.C.3
Sancak, Y.4
Kang, S.A.5
Kuehl, W.M.6
-
9
-
-
0036713778
-
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
-
Inoki K, Li Y, Zhu T, Wu J, Guan KL. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol 2002; 4:648-57.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 648-657
-
-
Inoki, K.1
Li, Y.2
Zhu, T.3
Wu, J.4
Guan, K.L.5
-
10
-
-
0043127125
-
Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
-
Inoki K, Li Y, Xu T, Guan KL. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev 2003; 17:1829-34.
-
(2003)
Genes Dev
, vol.17
, pp. 1829-1834
-
-
Inoki, K.1
Li, Y.2
Xu, T.3
Guan, K.L.4
-
11
-
-
36049043184
-
Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38
-
Bai X, Ma D, Liu A, Shen X, Wang QJ, Liu Y, et al. Rheb activates mTOR by antagonizing its endogenous inhibitor, FKBP38. Science 2007; 318:977-80.
-
(2007)
Science
, vol.318
, pp. 977-980
-
-
Bai, X.1
Ma, D.2
Liu, A.3
Shen, X.4
Wang, Q.J.5
Liu, Y.6
-
12
-
-
33749076673
-
SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity
-
Jacinto E, Facchinetti V, Liu D, Soto N, Wei S, Jung SY, et al. SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell 2006; 127:125-37.
-
(2006)
Cell
, vol.127
, pp. 125-137
-
-
Jacinto, E.1
Facchinetti, V.2
Liu, D.3
Soto, N.4
Wei, S.5
Jung, S.Y.6
-
13
-
-
7944235758
-
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
-
Jacinto E, Loewith R, Schmidt A, Lin S, Ruegg MA, Hall A, et al. Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat Cell Biol 2004; 6:1122-8.
-
(2004)
Nat Cell Biol
, vol.6
, pp. 1122-1128
-
-
Jacinto, E.1
Loewith, R.2
Schmidt, A.3
Lin, S.4
Ruegg, M.A.5
Hall, A.6
-
14
-
-
3342895823
-
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
-
Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, Erdjument-Bromage H, et al. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol 2004; 14:1296-302.
-
(2004)
Curr Biol
, vol.14
, pp. 1296-1302
-
-
Sarbassov, D.D.1
Ali, S.M.2
Kim, D.H.3
Guertin, D.A.4
Latek, R.R.5
Erdjument-Bromage, H.6
-
15
-
-
33751348056
-
Ablation in mice of the mTORC components raptor, rictor or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1
-
Guertin DA, Stevens DM, Thoreen CC, Burds AA, Kalaany NY, Moffat J, et al. Ablation in mice of the mTORC components raptor, rictor or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1. Dev Cell 2006; 11:859-71.
-
(2006)
Dev Cell
, vol.11
, pp. 859-871
-
-
Guertin, D.A.1
Stevens, D.M.2
Thoreen, C.C.3
Burds, A.A.4
Kalaany, N.Y.5
Moffat, J.6
-
16
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
Sarbassov DD, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005; 307:1098-101.
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
17
-
-
44949215822
-
The TSC1-TSC2 complex is required for proper activation of mTOR complex 2
-
Huang J, Dibble CC, Matsuzaki M, Manning BD. The TSC1-TSC2 complex is required for proper activation of mTOR complex 2. Mol Cell Biol 2008; 28:4104-15.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 4104-4115
-
-
Huang, J.1
Dibble, C.C.2
Matsuzaki, M.3
Manning, B.D.4
-
18
-
-
70350545722
-
Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1
-
Dibble CC, Asara JM, Manning BD. Characterization of Rictor phosphorylation sites reveals direct regulation of mTOR complex 2 by S6K1. Mol Cell Biol 2009; 29:5657-70.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 5657-5670
-
-
Dibble, C.C.1
Asara, J.M.2
Manning, B.D.3
-
19
-
-
33847001284
-
The kinases aurora B and mTOR regulate the G1-S cell cycle progression of T lymphocytes
-
Song J, Salek-Ardakani S, So T, Croft M. The kinases aurora B and mTOR regulate the G1-S cell cycle progression of T lymphocytes. Nat Immunol 2007; 8:64-73.
-
(2007)
Nat Immunol
, vol.8
, pp. 64-73
-
-
Song, J.1
Salek-Ardakani, S.2
So, T.3
Croft, M.4
-
20
-
-
62849087835
-
The TSC-mTOR pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor- or rictor-independent manner
-
Patursky-Polischuk I, Stolovich-Rain M, Hausner-Hanochi M, Kasir J, Cybulski N, Avruch J, et al. The TSC-mTOR pathway mediates translational activation of TOP mRNAs by insulin largely in a raptor- or rictor-independent manner. Mol Cell Biol 2009; 29:640-9.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 640-649
-
-
Patursky-Polischuk, I.1
Stolovich-Rain, M.2
Hausner-Hanochi, M.3
Kasir, J.4
Cybulski, N.5
Avruch, J.6
-
21
-
-
0028950217
-
Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells
-
Sabers CJ, Martin MM, Brunn GJ, Williams JM, Dumont FJ, Wiederrecht G, et al. Isolation of a protein target of the FKBP12-rapamycin complex in mammalian cells. J Biol Chem 1995; 270:815-22.
-
(1995)
J Biol Chem
, vol.270
, pp. 815-822
-
-
Sabers, C.J.1
Martin, M.M.2
Brunn, G.J.3
Williams, J.M.4
Dumont, F.J.5
Wiederrecht, G.6
-
22
-
-
0028598672
-
RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex
-
Chiu MI, Katz H, Berlin V. RAPT1, a mammalian homolog of yeast Tor, interacts with the FKBP12/rapamycin complex. Proc Natl Acad Sci USA 1994; 91:12574-8.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 12574-12578
-
-
Chiu, M.I.1
Katz, H.2
Berlin, V.3
-
23
-
-
0028239893
-
RAFT1: A mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs
-
Sabatini DM, Erdjument-Bromage H, Lui M, Tempst P, Snyder SH. RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell 1994; 78:35-43.
-
(1994)
Cell
, vol.78
, pp. 35-43
-
-
Sabatini, D.M.1
Erdjument-Bromage, H.2
Lui, M.3
Tempst, P.4
Snyder, S.H.5
-
24
-
-
33646023695
-
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
-
Sarbassov DD, Ali SM, Sengupta S, Sheen JH, Hsu PP, Bagley AF, et al. Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol Cell 2006; 22:159-68.
-
(2006)
Mol Cell
, vol.22
, pp. 159-168
-
-
Sarbassov, D.D.1
Ali, S.M.2
Sengupta, S.3
Sheen, J.H.4
Hsu, P.P.5
Bagley, A.F.6
-
25
-
-
33846909503
-
A role for mammalian target of rapamycin in regulating T cell activation versus anergy
-
Zheng Y, Collins SL, Lutz MA, Allen AN, Kole TP, Zarek PE, et al. A role for mammalian target of rapamycin in regulating T cell activation versus anergy. J Immunol 2007; 178:2163-70.
-
(2007)
J Immunol
, vol.178
, pp. 2163-2170
-
-
Zheng, Y.1
Collins, S.L.2
Lutz, M.A.3
Allen, A.N.4
Kole, T.P.5
Zarek, P.E.6
-
26
-
-
0033104824
-
Inhibition of cell cycle progression by rapamycin induces T cell clonal anergy even in the presence of costimulation
-
Powell JD, Lerner CG, Schwartz RH. Inhibition of cell cycle progression by rapamycin induces T cell clonal anergy even in the presence of costimulation. J Immunol 1999; 162:2775-84.
-
(1999)
J Immunol
, vol.162
, pp. 2775-2784
-
-
Powell, J.D.1
Lerner, C.G.2
Schwartz, R.H.3
-
27
-
-
66949173728
-
The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment
-
Delgoffe GM, Kole TP, Zheng Y, Zarek PE, Matthews KL, Xiao B, et al. The mTOR kinase differentially regulates effector and regulatory T cell lineage commitment. Immunity 2009; 30:832-44.
-
(2009)
Immunity
, vol.30
, pp. 832-844
-
-
Delgoffe, G.M.1
Kole, T.P.2
Zheng, Y.3
Zarek, P.E.4
Matthews, K.L.5
Xiao, B.6
-
28
-
-
0035284805
-
Uncoupling p70(s6) kinase activation and proliferation: Rapamycin-resistant proliferation of human CD8(+) T lymphocytes
-
Slavik JM, Lim DG, Burakoff SJ, Haf ler DA. Uncoupling p70(s6) kinase activation and proliferation: rapamycin-resistant proliferation of human CD8(+) T lymphocytes. J Immunol 2001; 166:3201-9.
-
(2001)
J Immunol
, vol.166
, pp. 3201-3209
-
-
Slavik, J.M.1
Lim, D.G.2
Burakoff, S.J.3
Haf Ler, D.A.4
-
29
-
-
0346463082
-
kip1 downregulation and bcl-xL induction, and is prevented by an inhibitor of phosphoinositide 3-kinase activity
-
kip1 downregulation and bcl-xL induction, and is prevented by an inhibitor of phosphoinositide 3-kinase activity. J Biol Chem 2004; 279:910-9.
-
(2004)
J Biol Chem
, vol.279
, pp. 910-919
-
-
Slavik, J.M.1
Lim, D.G.2
Burakoff, S.J.3
Haf Ler, D.A.4
-
30
-
-
67650074206
-
mTOR regulates memory CD8 T-cell differentiation
-
Araki K, Turner AP, Shaffer VO, Gangappa S, Keller SA, Bachmann MF, et al. mTOR regulates memory CD8 T-cell differentiation. Nature 2009; 460:108-12.
-
(2009)
Nature
, vol.460
, pp. 108-112
-
-
Araki, K.1
Turner, A.P.2
Shaffer, V.O.3
Gangappa, S.4
Keller, S.A.5
Bachmann, M.F.6
-
31
-
-
74649085700
-
+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin
-
+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin. Immunity 2010; 32:67-78.
-
(2010)
Immunity
, vol.32
, pp. 67-78
-
-
Rao, R.R.1
Li, Q.2
Odunsi, K.3
Shrikant, P.A.4
-
33
-
-
33746547247
-
The biology of interleukin-2 and interleukin-15: Implications for cancer therapy and vaccine design
-
Waldmann TA. The biology of interleukin-2 and interleukin-15: implications for cancer therapy and vaccine design. Nat Rev Immunol 2006; 6:595-601.
-
(2006)
Nat Rev Immunol
, vol.6
, pp. 595-601
-
-
Waldmann, T.A.1
-
34
-
-
33644556146
-
Prolonged TCR/CD28 engagement drives IL-2-independent T cell clonal expansion through signaling mediated by the mammalian target of rapamycin
-
Colombetti S, Basso V, Mueller DL, Mondino A. Prolonged TCR/CD28 engagement drives IL-2-independent T cell clonal expansion through signaling mediated by the mammalian target of rapamycin. J Immunol 2006; 176:2730-8.
-
(2006)
J Immunol
, vol.176
, pp. 2730-2738
-
-
Colombetti, S.1
Basso, V.2
Mueller, D.L.3
Mondino, A.4
-
35
-
-
61349141302
-
Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2
-
Feldman ME, Apsel B, Uotila A, Loewith R, Knight ZA, Ruggero D, et al. Active-site inhibitors of mTOR target rapamycin-resistant outputs of mTORC1 and mTORC2. PLoS Biol 2009; 7:38.
-
(2009)
PLoS Biol
, vol.7
, pp. 38
-
-
Feldman, M.E.1
Apsel, B.2
Uotila, A.3
Loewith, R.4
Knight, Z.A.5
Ruggero, D.6
-
36
-
-
65549145048
-
An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1
-
Thoreen CC, Kang SA, Chang JW, Liu Q, Zhang J, Gao Y, et al. An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J Biol Chem 2009; 284:8023-32.
-
(2009)
J Biol Chem
, vol.284
, pp. 8023-8032
-
-
Thoreen, C.C.1
Kang, S.A.2
Chang, J.W.3
Liu, Q.4
Zhang, J.5
Gao, Y.6
-
37
-
-
8544234990
-
Recent developments in the transcriptional regulation of cytolytic effector cells
-
Glimcher LH, Townsend MJ, Sullivan BM, Lord GM. Recent developments in the transcriptional regulation of cytolytic effector cells. Nat Rev Immunol 2004; 4:900-11.
-
(2004)
Nat Rev Immunol
, vol.4
, pp. 900-911
-
-
Glimcher, L.H.1
Townsend, M.J.2
Sullivan, B.M.3
Lord, G.M.4
-
39
-
-
20244375369
-
Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytes
-
Manjunath N, Shankar P, Wan J, Weninger W, Crowley MA, Hieshima K, et al. Effector differentiation is not prerequisite for generation of memory cytotoxic T lymphocytes. J Clin Invest 2001; 108:871-8.
-
(2001)
J Clin Invest
, vol.108
, pp. 871-878
-
-
Manjunath, N.1
Shankar, P.2
Wan, J.3
Weninger, W.4
Crowley, M.A.5
Hieshima, K.6
-
40
-
-
74549216531
-
Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells
-
Pipkin ME, Sacks JA, Cruz-Guilloty F, Lichtenheld MG, Bevan MJ, Rao A. Interleukin-2 and inflammation induce distinct transcriptional programs that promote the differentiation of effector cytolytic T cells. Immunity 2010; 32:79-90.
-
(2010)
Immunity
, vol.32
, pp. 79-90
-
-
Pipkin, M.E.1
Sacks, J.A.2
Cruz-Guilloty, F.3
Lichtenheld, M.G.4
Bevan, M.J.5
Rao, A.6
-
41
-
-
74549162832
-
Prolonged interleukin-2R-alpha expression on virus-specific CD8+ T cells favors terminal-effector differentiation in vivo
-
Kalia V, Sarkar S, Subramaniam S, Haining WN, Smith KA, Ahmed R. Prolonged interleukin-2R-alpha expression on virus-specific CD8+ T cells favors terminal-effector differentiation in vivo. Immunity 2010; 32:91-103.
-
(2010)
Immunity
, vol.32
, pp. 91-103
-
-
Kalia, V.1
Sarkar, S.2
Subramaniam, S.3
Haining, W.N.4
Smith, K.A.5
Ahmed, R.6
-
42
-
-
42449110816
-
Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking
-
Sinclair LV, Finlay D, Feijoo C, Cornish GH, Gray A, Ager A, et al. Phosphatidylinositol-3-OH kinase and nutrient-sensing mTOR pathways control T lymphocyte trafficking. Nat Immunol 2008; 9:513-21.
-
(2008)
Nat Immunol
, vol.9
, pp. 513-521
-
-
Sinclair, L.V.1
Finlay, D.2
Feijoo, C.3
Cornish, G.H.4
Gray, A.5
Ager, A.6
-
43
-
-
33745837261
-
Differential regulation of T-cell growth by IL-2 and IL-15
-
Cornish GH, Sinclair LV, Cantrell DA. Differential regulation of T-cell growth by IL-2 and IL-15. Blood 2006; 108:600-8.
-
(2006)
Blood
, vol.108
, pp. 600-608
-
-
Cornish, G.H.1
Sinclair, L.V.2
Cantrell, D.A.3
-
44
-
-
0037151120
-
Global and specific translational control by rapamycin in T cells uncovered by microarrays and proteomics
-
Grolleau A, Bowman J, Pradet-Balade B, Puravs E, Hanash S, Garcia-Sanz JA, et al. Global and specific translational control by rapamycin in T cells uncovered by microarrays and proteomics. J Biol Chem 2002; 277:22175-84.
-
(2002)
J Biol Chem
, vol.277
, pp. 22175-22184
-
-
Grolleau, A.1
Bowman, J.2
Pradet-Balade, B.3
Puravs, E.4
Hanash, S.5
Garcia-Sanz, J.A.6
-
45
-
-
0028034233
-
Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5′-cap function
-
Pause A, Belsham GJ, Gingras AC, Donze O, Lin TA, Lawrence JC Jr, et al. Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5′-cap function. Nature 1994; 371:762-7.
-
(1994)
Nature
, vol.371
, pp. 762-767
-
-
Pause, A.1
Belsham, G.J.2
Gingras, A.C.3
Donze, O.4
Lin, T.A.5
Lawrence Jr., J.C.6
-
46
-
-
0030066934
-
Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation
-
Beretta L, Gingras AC, Svitkin YV, Hall MN, Sonenberg N. Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation. EMBO J 1996; 15:658-64.
-
(1996)
EMBO J
, vol.15
, pp. 658-664
-
-
Beretta, L.1
Gingras, A.C.2
Svitkin, Y.V.3
Hall, M.N.4
Sonenberg, N.5
-
47
-
-
0035498939
-
Hierarchical phosphorylation of the translation inhibitor 4E-BP1
-
Gingras AC, Raught B, Gygi SP, Niedzwiecka A, Miron M, Burley SK, et al. Hierarchical phosphorylation of the translation inhibitor 4E-BP1. Genes Dev 2001; 15:2852-64.
-
(2001)
Genes Dev
, vol.15
, pp. 2852-2864
-
-
Gingras, A.C.1
Raught, B.2
Gygi, S.P.3
Niedzwiecka, A.4
Miron, M.5
Burley, S.K.6
-
48
-
-
77649286736
-
Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E
-
Hsieh AC, Costa M, Zollo O, Davis C, Feldman ME, Testa JR, et al. Genetic dissection of the oncogenic mTOR pathway reveals druggable addiction to translational control via 4EBP-eIF4E. Cancer Cell 17:249-61.
-
Cancer Cell
, vol.17
, pp. 249-261
-
-
Hsieh, A.C.1
Costa, M.2
Zollo, O.3
Davis, C.4
Feldman, M.E.5
Testa, J.R.6
-
49
-
-
0033879560
-
Isolation of translationally controlled mRNAs by differential screening
-
Mikulits W, Pradet-Balade B, Habermann B, Beug H, Garcia-Sanz JA, Mullner EW. Isolation of translationally controlled mRNAs by differential screening. FASEB J 2000; 14:1641-52.
-
(2000)
FASEB J
, vol.14
, pp. 1641-1652
-
-
Mikulits, W.1
Pradet-Balade, B.2
Habermann, B.3
Beug, H.4
Garcia-Sanz, J.A.5
Mullner, E.W.6
-
50
-
-
41149133368
-
Translational control of the innate immune response through IRF-7
-
Colina R, Costa-Mattioli M, Dowling RJ, Jaramillo M, Tai LH, Breitbach CJ, et al. Translational control of the innate immune response through IRF-7. Nature 2008; 452:323-8.
-
(2008)
Nature
, vol.452
, pp. 323-328
-
-
Colina, R.1
Costa-Mattioli, M.2
Dowling, R.J.3
Jaramillo, M.4
Tai, L.H.5
Breitbach, C.J.6
-
51
-
-
73349119966
-
MAPK, phosphatidylinositol 3-kinase, and mammalian target of rapamycin pathways converge at the level of ribosomal protein S6 phosphorylation to control metabolic signaling in CD8 T cells
-
Salmond RJ, Emery J, Okkenhaug K, Zamoyska R. MAPK, phosphatidylinositol 3-kinase, and mammalian target of rapamycin pathways converge at the level of ribosomal protein S6 phosphorylation to control metabolic signaling in CD8 T cells. J Immunol 2009; 183:7388-97.
-
(2009)
J Immunol
, vol.183
, pp. 7388-7397
-
-
Salmond, R.J.1
Emery, J.2
Okkenhaug, K.3
Zamoyska, R.4
-
52
-
-
29144438951
-
Inactivation of S6 ribosomal protein gene in T lymphocytes activates a p53-dependent checkpoint response
-
Sulic S, Panic L, Barkic M, Mercep M, Uzelac M, Volarevic S. Inactivation of S6 ribosomal protein gene in T lymphocytes activates a p53-dependent checkpoint response. Genes Dev 2005; 19:3070-82.
-
(2005)
Genes Dev
, vol.19
, pp. 3070-3082
-
-
Sulic, S.1
Panic, L.2
Barkic, M.3
Mercep, M.4
Uzelac, M.5
Volarevic, S.6
-
53
-
-
24944464482
-
Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis
-
Ruvinsky I, Sharon N, Lerer T, Cohen H, Stolovich-Rain M, Nir T, et al. Ribosomal protein S6 phosphorylation is a determinant of cell size and glucose homeostasis. Genes Dev 2005; 19:2199-211.
-
(2005)
Genes Dev
, vol.19
, pp. 2199-2211
-
-
Ruvinsky, I.1
Sharon, N.2
Lerer, T.3
Cohen, H.4
Stolovich-Rain, M.5
Nir, T.6
-
54
-
-
41549107522
-
Cytokine signaling modules in inflammatory responses
-
O'Shea JJ, Murray PJ. Cytokine signaling modules in inflammatory responses. Immunity 2008; 28:477-87.
-
(2008)
Immunity
, vol.28
, pp. 477-487
-
-
O'Shea, J.J.1
Murray, P.J.2
-
55
-
-
12544252206
-
Interleukin-12-induced interferon-gamma production by human peripheral blood T cells is regulated by mammalian target of rapamycin (mTOR)
-
Kusaba H, Ghosh P, Derin R, Buchholz M, Sasaki C, Madara K, et al. Interleukin-12-induced interferon-gamma production by human peripheral blood T cells is regulated by mammalian target of rapamycin (mTOR). J Biol Chem 2005; 280:1037-43.
-
(2005)
J Biol Chem
, vol.280
, pp. 1037-1043
-
-
Kusaba, H.1
Ghosh, P.2
Derin, R.3
Buchholz, M.4
Sasaki, C.5
Madara, K.6
-
56
-
-
0141780844
-
Stimulation of signal transducer and activator of transcription-1 (STAT1)-dependent gene transcription by lipopolysaccharide and interferon-gamma is regulated by mammalian target of rapamycin
-
Kristof AS, Marks-Konczalik J, Billings E, Moss J. Stimulation of signal transducer and activator of transcription-1 (STAT1)-dependent gene transcription by lipopolysaccharide and interferon-gamma is regulated by mammalian target of rapamycin. J Biol Chem 2003; 278:33637-44.
-
(2003)
J Biol Chem
, vol.278
, pp. 33637-33644
-
-
Kristof, A.S.1
Marks-Konczalik, J.2
Billings, E.3
Moss, J.4
-
57
-
-
70449393602
-
Rapamycin: Could it enhance vaccine efficacy?
-
Nam JH. Rapamycin: could it enhance vaccine efficacy? Expert Rev Vaccines 2009; 8:1535-9.
-
(2009)
Expert Rev Vaccines
, vol.8
, pp. 1535-1539
-
-
Nam, J.H.1
|