p85 plays a critical role in controlling flux through the PI3K/PTEN signaling axis through dual regulation of both p110 (PI3K) and PTEN

Cell Cycle

Volumn 9, Issue 11, 2010, Pages 2055-2056

  Anderson, Deborah H ^a  

^a SASKATCHEWAN CANCER AGENCY   (Canada)

Author keywords

Explains mouse phenotypes; Insulin signaling; Lipid phosphatase; p85 regulation; PI3 kinase pathway; Protein:protein interactions; PTEN tumor suppressor

Indexed keywords

GUANOSINE TRIPHOSPHATASE; HEAT SHOCK PROTEIN 110; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN P85;

CATALYSIS; EDITORIAL; ENZYME ACTIVITY; GEL FILTRATION; GENE DELETION; GENE MUTATION; GENETIC CODE; PHENOTYPE; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FOLDING; SIGNAL TRANSDUCTION;

EID: 77953602479     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.9.11.11926     Document Type: Editorial

References (11)

1. Yuan TL, Cantley LC. Oncogene 2008; 27:5497-510.
2. Chagpar RB, et al. Proc Natl Acad Sci USA 2010;107:5471-6.
3. Vazquez F, et al. J Biol Chem 2001; 276:48627-30.
4. Rabinovsky R, et al. Mol Cell Biol 2009; 29:5377-88.
5. Ueki K, et al. Mol Cell Biol 2000; 20:8035-46.
6. Ueki K, et al. Mol Cell Biol 2002; 22:965-77.
7. Brachmann SM, et al. Mol Cell Biol 2005; 25:1596-607.
8. Fruman DA, et al. Nat Genet 2000; 26:379-82.
9. Wong JT, et al. Diabetologia 2007; 50:395-403.
10. Chamberlain MD, et al. J Biol Chem 2004; 279:48607-14.
11. Chamberlain MD, et al. J Biol Chem 2008;283:15861-8.