Mitotic aberration coupled with centrosome amplification is induced by hepatitis B virus X oncoprotein via the Ras-mitogen-activated protein/extracellular signal-regulated kinase-mitogen-activated protein pathway

Molecular Cancer Research

Volumn 2, Issue 3, 2004, Pages 159-169

  Yun, Chawon ^a   Cho, Hyeseon ^a,b   Kim, Su Jeong ^a   Lee, Jae Ho ^a   Park, Sun Yi ^a   Chan, Gordon K ^c   Cho, Hyeseong ^a  

^a Ajou University School of Medicine   (South Korea)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c CROSS CANCER INSTITUTE   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; HEPATITIS B VIRUS X PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; ONCOPROTEIN; RAS PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL TRANSFORMATION; CENTROSOME; CHROMOSOME ABERRATION; CHROMOSOME SEGREGATION; GENETIC STABILITY; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; HUMAN CELL; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; PRIORITY JOURNAL;

CELL LINE; CENTROSOME; FLAVONOIDS; HUMANS; MAP KINASE SIGNALING SYSTEM; MICRONUCLEI, CHROMOSOME-DEFECTIVE; MITOGEN-ACTIVATED PROTEIN KINASES; MITOSIS; MITOTIC SPINDLE APPARATUS; MUTATION; RAS PROTEINS; TRANS-ACTIVATORS; TRANSFECTION;

DNA VIRUSES; HEPATITIS B VIRUS;

EID: 3543150890     PISSN: 15417786     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (57)

1. Margolis HS, Alter MJ, Hadler SC. Hepatitis B: evolving epidemiology and implications for control. Semin Liver Dis, 1991;11:84-92.
2. Da Villa G, Sepe A, Piccinino F, Scolastico C. Pilot project of universal hepatitis B vaccination of newborns in a hyperendemic area: results after 17 years. In: Margolis HS, Alter MJ, Liang TJ, Dienstag JL, editors. Viral Hepatitis and Liver Disease. Atlanta: International Medical Press; 2002. p. 258-60.
3. Livezey KW, Negorev D, Simon D. Hepatitis B virus-transfected Hep G2 cells demonstrate genetic alterations and de novo viral integration in cells replicating HBV. Mutat Res, 2000;452:163-78.
4. Bouchard MJ, Puro RJ, Wang L, Schneider RJ. Activation and inhibition of cellular calcium and tyrosine kinase signaling pathways identify targets of the HBx protein involved in hepatitis B virus replication. J Virol, 2003;77:7713-9.
5. Bouchard MJ, Wang LH, Schneider RJ. Calcium signaling by HBx protein in hepatitis B virus DNA replication. Science, 2001;294:2376-8.
6. Koike K, Tsutsumi T, Fujie H, Shintani Y, Kyoji M. Molecular mechanism of viral hepatocarcinogenesis. Oncology, 2002;62 Suppl 1:29-37.
7. Kim CM, Koike K, Saito I, Miyamura T, Jay G. HBx gene of hepatitis B virus induces liver cancer in transgenic mice. Nature, 1991;351:317-20.
8. Yu DY, Moon HB, Son JK, et al. Incidence of hepatocellular carcinoma in transgenic mice expressing the hepatitis B virus X-protein. J Hepatol, 1999;31:123-32.
9. Slagle BL, Lee TH, Medina D, Finegold MJ, Butel JS. Increased sensitivity to the hepatocarcinogen diethylnitrosamine in transgenic mice carrying the hepatitis B virus X gene. Mol Carcinog, 1996;15:261-9.
10. Terradillos O, Billet O, Renard CA, et al. The hepatitis B virus X gene potentiates c-myc-induced liver oncogenesis in transgenic mice. Oncogene, 1997;14:395-404.
11. Höhne M, Schaefer S, Sefer M, Feitelson MA, Paul D, Gerlich WH. Malignant transformation of immortalized transgenic hepatocytes after transfection with hepatitis B virus DNA. EMBO J, 1990;9:1137-45.
12. Koikë K, Moriya K, Yotsuyanagi H, Iino S, Kurokawa K. Induction of cell cycle progression by hepatitis B virus HBx gene expression in quiescent mouse fibroblasts. J Clin Invest, 1994;94:44-9.
13. Benn J, Schneider RJ. Hepatitis B virus HBx protein activates Ras-GTP complex formation and establishes a Ras, Raf, MAP kinase signaling cascade. Proc Natl Acad Sci USA, 1994;91:10350-4.
14. Klein NP, Schneider RJ. Activation of Src family kinases by hepatitis B virus HBx protein and coupled signaling to Ras. Mol Cell Biol, 1997;17:6427-36.
15. Tarn C, Lee S, Hu Y, Ashendel C, Andrisani OM. Hepatitis B virus X protein differentially activates RAS-RAF-MAPK and JNK pathways in X-transforming versus non-transforming AML12 hepatocytes. J Biol Chem, 2001;276:34671-80.
16. Tarn C, Zou L, Hullinger RL, Andrisani OM. Hepatitis B virus X protein activates the p38 mitogen-activated protein kinase pathway in dedifferentiated hepatocytes. J Virol, 2002;76:9763-72.
17. Shih WL, Kuo ML, Chuang SE, Cheng AL, Doong SL. Hepatitis B virus X protein inhibits transforming growth factor-β-induced apoptosis through the activation of phosphatidylinositol 3-kinase pathway. J Biol Chem, 2000;275:25858-64.
18. Diao J, Khine AA, Sarangi F, et al. X protein of hepatitis B virus inhibits Fas-mediated apoptosis and is associated with up-regulation of the SAPK/JNK pathway. J Biol Chem, 2001;276:8328-40.
19. Dore MP, Realdi G, Mura D, et al. Genomic instability in chronic viral hepatitis and hepatocellular carcinoma. Hum Pathol, 2001;32:698-703.
20. Laurent-Puig P, Legoix P, Bluteau O, et al. Genetic alterations associated with hepatocellular carcinomas define distinct pathways of hepatocarcinogenesis. Gastroenterology, 2001;120:1763-73.
21. Livezey KW, Negorev D, Simon D. Increased chromosomal alterations and micronuclei formation in human hepatoma HepG2 cells transfected with the hepatitis B virus HBX gene. Mutat Res, 2002;505:63-74.
22. Oguey D, Dumenco LL, Pierce RH, Fausto N. Analysis of the tumorigenicity of the X gene of hepatitis B virus in a nontransformed hepatocyte cell line and the effects of cotransfection with a murine p53 mutant equivalent to human codon 249. Hepatology, 1996;24:1024-33.
23. Lee S, Tarn C, Wang WH, Chen S, Hullinger RL, Andrisani OM. Hepatitis B virus X protein differentially regulates cell cycle progression in X-transforming versus nontransforming hepatocyte (AML12) cell lines. J Biol Chem, 2002;277:8730-40.
24. Jin DY, Spencer F, Jeang KT. Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD 1. Cell, 1998;93:81-91.
25. Parker GA, Touitou R, Allday MJ. Epstein-Barr virus EBNA3C can disrupt multiple cell cycle checkpoints and induce nuclear division divorced from cytokinesis. Oncogene, 2000;19:700-9.
26. D'Assoro AB, Lingle WL, Salisbury JL. Centrosome amplification and the development of cancer. Oncogene, 2002;21:6146-53.
27. Duensing S, Lee LY, Duensing A, et al. The human papillomavirus type 16 E6 and E7 oncoproteins; cooperate to induce mitotic defects and genomic instability by uncoupling centrosome duplication from the cell division cycle. Proc Natl Acad Sci USA, 2000;97:10002-7.
28. Duensing S, Munger K. Dissection of human papillomavirus E6 and E7 function in transgenic mouse models of cervical carcinogenesis. Cancer Res, 2002;62:7075-82.
29. De Luca A, Mangiacasale R, Severino A, et al. E1A deregulates the centrosome cycle in a Ran GTPase-dependent manner. Cancer Res, 2003;63:1430-7.
30. Gaillard S, Fahrbach KM, Parkati R, Rundell K. Overexpression of simian virus 40 small-T antigen blocks centrosome function and mitotic progression in human fibroblasts. J Virol, 2001;75:9799-807.
31. Yun C, Lee JH, Park H, et al. Chemotherapeutic drug, Adriamycin, restores the function of p53 protein in hepatitis B virus X (HBx) protein-expressing liver cells. Oncogene, 2000;19:5163-72.
32. Yun C, Um HR, Jin YH, et al. NF-κB activation by hepatitis B virus X (HBx) protein shifts the cellular fate toward survival. Cancer Lett, 2002;184:97-104.
33. Lara-Pezzi E, Roche S, Andrisani OM, Sanchez-Madrid F, Lopez-Cabrera M. The hepatitis B virus HBx protein induces adherens junction disruption in a src-dependent manner. Oncogene, 2001;20:3323-31.
34. Lara-Pezzi E, Serrador JM, Montoya MC, et al. The hepatitis B virus X protein (HBx) induces a migratory phenotype in a CD44-dependent manner: possible role of HBx in invasion and metastasis. Hepatology, 2001;33:1270-81.
35. Arbuthnot P, Capovilla A, Kew M. Putative role of hepatitis B virus X protein in hepatocarcinogenesis: effects on apoptosis, DNA repair, mitogen-activated protein kinase and JAK/STAT pathways, J Gastroenterol Hepatol, 2000;15:357-68.
36. Shirakata Y, Kawada M, Fujiki Y, et al. The X gene of hepatitis B virus induced growth stimulation and tumorigenic transformation of mouse NIH3T3 cells. Jpn J Cancer Res, 1989;80:617-21.
37. Pihan GA, Wallace J, Zhou Y, Doxsey SJ. Centrosome abnormalities and chromosome instability occur together in pre-invasive carcinomas. Cancer Res, 2003;63:1398-404.
38. Roberts EC, Shapiro PS, Nahreini TS, Pages G, Pouyssegur J, Ahn NG. Distinct cell cycle timing requirements for extracellular signal-regulated kinase and phosphoinositide 3-kinase signaling pathways in somatic cell mitosis. Mol Cell Biol, 2002;22:7226-41.
39. Chung TW, Lee YC, Ko JH, Kim CH. Hepatitis B Virus X protein modulates the expression of PTEN by inhibiting the function of p53, a transcriptional activator in liver cells. Cancer Res, 2003;63:3453-8.
40. Bae MA, Song BJ. Critical role of c-Jun N-terminal protein kinase activation in troglitazone-induced apoptosis of human HepG2 hepatoma cells. Mol Pharmacol, 2003;63:401-8.
41. Livezey KW, Simon D. Accumulation of genetic alterations in a human hepatoma cell line transfected with hepatitis B virus. Mutat Res, 1997;377:187-98.
42. Kim YC, Song KS, Yoon G, Nam MJ, Ryu WS. Activated ras oncogene collaborates with HBx gene of hepatitis B virus to transform cells by suppressing HBx-mediated apoptosis. Oncogene, 2001;20:16-23.
43. Forgues M, Difilippantonio MJ, Linke SP, et al. Involvement of Crm1 in hepatitis B virus X protein-induced aberrant centriole replication and abnormal mitotic spindles. Mol Cell Biol, 2003;23:5282-92.
44. Ouyang X, Wang X, Xu K, et al. Effect of p53 on centrosome amplification in prostate cancer cells. Biochim Biophys Acta, 2001;1541:212-20.
45. Tarapore P, Tokuyama Y, Horn HF, Fukasawa K. Direct regulation of the centrosome duplication cycle by the p53-p21Waf1/Cip1 pathway. Oncogene, 2001;20:6851-63.
46. Chan GK, Jablonski SA, Sudakin V, Hittle JC, Yen TJ. Human BUBRI is a mitotic checkpoint kinase that monitors CENP-E functions at kinetochores and binds the cyclosome/APC. J Cell Biol, 1999;146:941-54.
47. McEwen BF, Chan GK, Zubrowski B, Savoian MS, Sauer MT, Yen TJ. CENP-E is essential for reliable bioriented spindle attachment, but chromosome alignment can be achieved via redundant mechanisms in mammalian cells. Mol Biol Cell, 2001;12:2776-89.
48. Sudakin V, Chan GK, Yen TJ. Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBRI, BUB3, CDC20, and MAD2. J Cell Biol, 2001;154:925-36.
49. Liu ST, Hittle JC, Jablonski SA, Campbell MS, Yoda K, Yen TJ. Human CENP-1 specifies localization of CENP-F, MADI and MAD2 to kinetochores and is essential for mitosis. Nat Cell Biol, 2003;5:341-5.
50. Kallio MJ, Nieminen M, Eriksson JE. Human inhibitor of apoptosis protein (1AP) survivin participates in regulation of chromosome segregation and mitotic exit. FASEB J, 2001;15:2721-3.
51. Marusawa H, Matsuzawa S, Welsh K, et al. HBXIP functions as a cofactor of survivin in apoptosis suppression. EMBO J, 2003;22:2729-40.
52. Madaule P, Eda M, Watanabe N, et al. Role of citron kinase as a target of the small GTPase Rho in cytokinesis. Nature, 1998;394:491-4.
53. Andjelkovic M, Jakubowicz T, Cron P, Ming XF, Han JW, Hemmings BA. Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors. Proc Natl Acad Sci USA, 1996;93:5699-704.
54. Boyer B, Roche S, Denoyelle M, Thiery JP. Src and Ras are involved in separate pathways in epithelial cell scattering. EMBO J, 1997;16:5904-13.
55. Abbott DW, Holt JT. Mitogen-activated protein kinase kinase 2 activation is essential for progression through the G2/M checkpoint arrest in cells exposed to ionizing radiation. J Biol Chem, 1999;274:2732-42.
56. Lim YB, Kang SS, Park TK, Lee YS, Chun JS, Sonn JK. Disruption of actin cytoskeleton induces chondrogenesis of mesenchymal cells by activating protein kinase C-α signaling. Biochem Biophys Res Commun, 2000;273:609-13.
57. Derijard B, Raingeaud J, Barrett T, et al. Independent human MAP-kinase signal transduction pathways defined by MEK and MKK isoforms. Science, 1995;267:682-5.