메뉴 건너뛰기




Volumn 89, Issue 3, 2009, Pages 777-798

LKB1 and AMPK family signaling: The intimate link between cell polarity and energy metabolism

Author keywords

[No Author keywords available]

Indexed keywords

HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; PROTEIN KINASE LKB1;

EID: 67650898228     PISSN: 00319333     EISSN: 15221210     Source Type: Journal    
DOI: 10.1152/physrev.00026.2008     Document Type: Review
Times cited : (191)

References (139)
  • 4
    • 33947526130 scopus 로고    scopus 로고
    • AMP-activated protein kinase in the heart: Role during health and disease
    • Arad M, Seidman CE, Seidman JG. AMP-activated protein kinase in the heart: role during health and disease. Circ Res 100: 474-488, 2007.
    • (2007) Circ Res , vol.100 , pp. 474-488
    • Arad, M.1    Seidman, C.E.2    Seidman, J.G.3
  • 13
    • 0347596668 scopus 로고    scopus 로고
    • Drosophila PAR-1 and 14-3-3 inhibit Bazooka/PAR-3 to establish complementary cortical domains in polarized cells
    • Benton R, St Johnston D. Drosophila PAR-1 and 14-3-3 inhibit Bazooka/PAR-3 to establish complementary cortical domains in polarized cells. Cell 115: 691-704, 2003.
    • (2003) Cell , vol.115 , pp. 691-704
    • Benton, R.1    St Johnston, D.2
  • 14
    • 4344648897 scopus 로고    scopus 로고
    • Dare to be different: Asymmetric cell division in Drosophila, C. elegans, and vertebrates
    • Betschinger J, Knoblich JA. Dare to be different: asymmetric cell division in Drosophila, C. elegans, and vertebrates. Curr Biol 14: R674-685, 2004.
    • (2004) Curr Biol , vol.14
    • Betschinger, J.1    Knoblich, J.A.2
  • 17
    • 0032946456 scopus 로고    scopus 로고
    • The hamartoma-adenoma-carcinoma sequence
    • Bosman FT. The hamartoma-adenoma-carcinoma sequence. J Pathol 188: 1-2, 1999.
    • (1999) J Pathol , vol.188 , pp. 1-2
    • Bosman, F.T.1
  • 18
    • 0141753981 scopus 로고    scopus 로고
    • Boudeau J, Baas AF, Deak M, Morrice NA, Kieloch A, Schutkowski M, Prescott AR, Clevers HC, Alessi DR. MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. EMBO J 22: 5102-5114, 2003.
    • Boudeau J, Baas AF, Deak M, Morrice NA, Kieloch A, Schutkowski M, Prescott AR, Clevers HC, Alessi DR. MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. EMBO J 22: 5102-5114, 2003.
  • 21
    • 33645766204 scopus 로고    scopus 로고
    • Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin
    • Bowker SL, Majumdar SR, Veugelers P, Johnson JA. Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin. Diabetes Care 29: 254-258, 2006.
    • (2006) Diabetes Care , vol.29 , pp. 254-258
    • Bowker, S.L.1    Majumdar, S.R.2    Veugelers, P.3    Johnson, J.A.4
  • 22
    • 1842581909 scopus 로고    scopus 로고
    • Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network
    • Brajenovic M, Joberty G, Kuster B, Bouwmeester T, Drewes G. Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network. J Biol Chem 279: 12804-12811, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 12804-12811
    • Brajenovic, M.1    Joberty, G.2    Kuster, B.3    Bouwmeester, T.4    Drewes, G.5
  • 24
    • 3142587052 scopus 로고    scopus 로고
    • Dysregulation of HIF and VEGF is a unifying feature of the familial hamartoma syndromes
    • Brugarolas J, Kaelin WG Jr. Dysregulation of HIF and VEGF is a unifying feature of the familial hamartoma syndromes. Cancer Cell 6: 7-10, 2004.
    • (2004) Cancer Cell , vol.6 , pp. 7-10
    • Brugarolas, J.1    Kaelin Jr., W.G.2
  • 25
    • 33744781836 scopus 로고    scopus 로고
    • Microtubule affinity-regulating kinase 2 functions downstream of the PAR-3/PAR-6/atypical PKC complex in regulating hippocampal neuronal polarity
    • Chen YM, Wang QJ, Hu HS, Yu PC, Zhu J, Drewes G, Piwnica-Worms H, Luo ZG. Microtubule affinity-regulating kinase 2 functions downstream of the PAR-3/PAR-6/atypical PKC complex in regulating hippocampal neuronal polarity. Proc Natl Acad Sci USA 103: 8534-8539, 2006.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 8534-8539
    • Chen, Y.M.1    Wang, Q.J.2    Hu, H.S.3    Yu, P.C.4    Zhu, J.5    Drewes, G.6    Piwnica-Worms, H.7    Luo, Z.G.8
  • 26
    • 0034141636 scopus 로고    scopus 로고
    • LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo
    • Collins SP, Reoma JL, Gamm DM, Uhler MD. LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo. Biochem J 345: 673-680, 2000.
    • (2000) Biochem J , vol.345 , pp. 673-680
    • Collins, S.P.1    Reoma, J.L.2    Gamm, D.M.3    Uhler, M.D.4
  • 28
    • 34247338972 scopus 로고    scopus 로고
    • Acto-myosin reorganization and PAR polarity in C. elegans
    • Cowan CR, Hyman AA. Acto-myosin reorganization and PAR polarity in C. elegans. Development 134: 1035-1043, 2007.
    • (2007) Development , vol.134 , pp. 1035-1043
    • Cowan, C.R.1    Hyman, A.A.2
  • 31
    • 26244445827 scopus 로고    scopus 로고
    • De Leng WW, Keller JJ, Luiten S, Musler AR, Jansen M, Baas AF, de Rooij FW, Gille JJ, Menko FH, Offerhaus GJ, Weterman MA. STRAD in Peutz-Jeghers syndrome and sporadic cancers. J Clin Pathol 58: 1091-1095, 2005.
    • De Leng WW, Keller JJ, Luiten S, Musler AR, Jansen M, Baas AF, de Rooij FW, Gille JJ, Menko FH, Offerhaus GJ, Weterman MA. STRAD in Peutz-Jeghers syndrome and sporadic cancers. J Clin Pathol 58: 1091-1095, 2005.
  • 32
    • 58649094677 scopus 로고    scopus 로고
    • Characterization of an alternative splice variant of LKB1
    • Denison FC, Hiscock NJ, Carling D, Woods A. Characterization of an alternative splice variant of LKB1. J Biol Chem 284: 67-76, 2009.
    • (2009) J Biol Chem , vol.284 , pp. 67-76
    • Denison, F.C.1    Hiscock, N.J.2    Carling, D.3    Woods, A.4
  • 33
    • 44949122687 scopus 로고    scopus 로고
    • STRADα regulates LKB1 localization by blocking access to importin-α, and by association with Crm1 and Exportin-7
    • Dorfman J, Macara IG. STRADα regulates LKB1 localization by blocking access to importin-α, and by association with Crm1 and Exportin-7. Mol Biol Cell 19: 1614-1626, 2008.
    • (2008) Mol Biol Cell , vol.19 , pp. 1614-1626
    • Dorfman, J.1    Macara, I.G.2
  • 37
    • 35549001736 scopus 로고    scopus 로고
    • The PAR proteins: Fundamental players in animal cell polarization
    • Goldstein B, Macara IG. The PAR proteins: fundamental players in animal cell polarization. Dev Cell 13: 609-622, 2007.
    • (2007) Dev Cell , vol.13 , pp. 609-622
    • Goldstein, B.1    Macara, I.G.2
  • 41
    • 34648828532 scopus 로고    scopus 로고
    • AMP-activated/SNF1 protein kinases: Conserved guardians of cellular energy
    • Hardie DG. AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. Nature Rev 8: 774-785, 2007.
    • (2007) Nature Rev , vol.8 , pp. 774-785
    • Hardie, D.G.1
  • 42
    • 0345107247 scopus 로고    scopus 로고
    • Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade
    • Hawley SA, Boudeau J, Reid JL, Mustard KJ, Udd L, Makela TP, Alessi DR, Hardie DG. Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J Biol 2: 28, 2003.
    • (2003) J Biol , vol.2 , pp. 28
    • Hawley, S.A.1    Boudeau, J.2    Reid, J.L.3    Mustard, K.J.4    Udd, L.5    Makela, T.P.6    Alessi, D.R.7    Hardie, D.G.8
  • 47
    • 3242662786 scopus 로고    scopus 로고
    • De novo germline mutation in the serine-threonine kinase STK11/LKB1 gene associated with Peutz-Jeghers syndrome
    • Hernan I, Roig I, Martin B, Gamundi MJ, Martinez-Gimeno M, Carballo M. De novo germline mutation in the serine-threonine kinase STK11/LKB1 gene associated with Peutz-Jeghers syndrome. Clin Genet 66: 58-62, 2004.
    • (2004) Clin Genet , vol.66 , pp. 58-62
    • Hernan, I.1    Roig, I.2    Martin, B.3    Gamundi, M.J.4    Martinez-Gimeno, M.5    Carballo, M.6
  • 52
    • 1942540791 scopus 로고    scopus 로고
    • Atypical PKC phosphorylates PAR-1 kinases to regulate localization and activity
    • Hurov JB, Watkins JL, Piwnica-Worms H. Atypical PKC phosphorylates PAR-1 kinases to regulate localization and activity. Curr Biol 14: 736-741, 2004.
    • (2004) Curr Biol , vol.14 , pp. 736-741
    • Hurov, J.B.1    Watkins, J.L.2    Piwnica-Worms, H.3
  • 53
    • 53749095429 scopus 로고    scopus 로고
    • Jang C, Lee G, Chung J. LKB1 induces apical trafficking of Silnoon, a monocarboxylate transporter, in Drosophila melanogaster. J Cell Biol 183: 11-17, 2008.
    • Jang C, Lee G, Chung J. LKB1 induces apical trafficking of Silnoon, a monocarboxylate transporter, in Drosophila melanogaster. J Cell Biol 183: 11-17, 2008.
  • 58
    • 0345832116 scopus 로고    scopus 로고
    • Knockout of the alpha2 but not alpha1 5′-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside but not contraction-induced glucose uptake in skeletal muscle
    • Jorgensen SB, Viollet B, Andreelli F, Frosig C, Birk JB, Schjerling P, Vaulont S, Richter EA, Wojtaszewski JF. Knockout of the alpha2 but not alpha1 5′-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside but not contraction-induced glucose uptake in skeletal muscle. J Biol Chem 279: 1070-1079, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 1070-1079
    • Jorgensen, S.B.1    Viollet, B.2    Andreelli, F.3    Frosig, C.4    Birk, J.B.5    Schjerling, P.6    Vaulont, S.7    Richter, E.A.8    Wojtaszewski, J.F.9
  • 62
    • 0024284814 scopus 로고
    • Identification of genes required for cytoplasmic localization in early C. elegans embryos
    • Kemphues KJ, Priess JR, Morton DG, Cheng NS. Identification of genes required for cytoplasmic localization in early C. elegans embryos. Cell 52: 311-320, 1988.
    • (1988) Cell , vol.52 , pp. 311-320
    • Kemphues, K.J.1    Priess, J.R.2    Morton, D.G.3    Cheng, N.S.4
  • 63
    • 1642396519 scopus 로고    scopus 로고
    • Enhanced stem cell survival in familial adenomatous polyposis
    • Kim KM, Calabrese P, Tavare S, Shibata D. Enhanced stem cell survival in familial adenomatous polyposis. Am J Pathol 164: 1369-1377, 2004.
    • (2004) Am J Pathol , vol.164 , pp. 1369-1377
    • Kim, K.M.1    Calabrese, P.2    Tavare, S.3    Shibata, D.4
  • 64
    • 0032524104 scopus 로고    scopus 로고
    • Landscaping the cancer terrain
    • Kinzler KW, Vogelstein B. Landscaping the cancer terrain. Science 280: 1036-1037, 1998.
    • (1998) Science , vol.280 , pp. 1036-1037
    • Kinzler, K.W.1    Vogelstein, B.2
  • 65
    • 13644267037 scopus 로고    scopus 로고
    • Mammalian SAD kinases are required for neuronal polarization
    • Kishi M, Pan YA, Crump JG, Sanes JR. Mammalian SAD kinases are required for neuronal polarization. Science 307: 929-932, 2005.
    • (2005) Science , vol.307 , pp. 929-932
    • Kishi, M.1    Pan, Y.A.2    Crump, J.G.3    Sanes, J.R.4
  • 66
    • 1642276419 scopus 로고    scopus 로고
    • Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout mice
    • Klezovitch O, Fernandez TE, Tapscott SJ, Vasioukhin V. Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout mice. Genes Dev 18: 559-571, 2004.
    • (2004) Genes Dev , vol.18 , pp. 559-571
    • Klezovitch, O.1    Fernandez, T.E.2    Tapscott, S.J.3    Vasioukhin, V.4
  • 67
    • 39149130360 scopus 로고    scopus 로고
    • Mechanisms of asymmetric stem cell division
    • Knoblich JA. Mechanisms of asymmetric stem cell division. Cell 132: 583-597, 2008.
    • (2008) Cell , vol.132 , pp. 583-597
    • Knoblich, J.A.1
  • 69
    • 34548179000 scopus 로고    scopus 로고
    • Suppression of tubulin polymerization by the LKB1-microtubule-associated protein/microtubule affinity-regulating kinase signaling
    • Kojima Y, Miyoshi H, Clevers HC, Oshima M, Aoki M, Taketo MM. Suppression of tubulin polymerization by the LKB1-microtubule-associated protein/microtubule affinity-regulating kinase signaling. J Biol Chem 282: 23532-23540, 2007.
    • (2007) J Biol Chem , vol.282 , pp. 23532-23540
    • Kojima, Y.1    Miyoshi, H.2    Clevers, H.C.3    Oshima, M.4    Aoki, M.5    Taketo, M.M.6
  • 70
    • 24644494270 scopus 로고    scopus 로고
    • Asymmetric cell divisions promote stratification and differentiation of mammalian skin
    • Lechler T, Fuchs E. Asymmetric cell divisions promote stratification and differentiation of mammalian skin. Nature 437: 275-280, 2005.
    • (2005) Nature , vol.437 , pp. 275-280
    • Lechler, T.1    Fuchs, E.2
  • 71
    • 31844432828 scopus 로고    scopus 로고
    • Lgl, Pins and aPKC regulate neuroblast self-renewal versus differentiation
    • Lee CY, Robinson KJ, Doe CQ. Lgl, Pins and aPKC regulate neuroblast self-renewal versus differentiation. Nature 439: 594-598, 2006.
    • (2006) Nature , vol.439 , pp. 594-598
    • Lee, C.Y.1    Robinson, K.J.2    Doe, C.Q.3
  • 73
    • 38849171845 scopus 로고    scopus 로고
    • Expansion of a mutated clone: From stem cell to tumour
    • Leedham SJ, Wright NA. Expansion of a mutated clone: from stem cell to tumour. J Clin Pathol 61: 164-171, 2008.
    • (2008) J Clin Pathol , vol.61 , pp. 164-171
    • Leedham, S.J.1    Wright, N.A.2
  • 75
    • 0019403076 scopus 로고
    • Does Peutz-Jeghers syndrome predispose to gastrointestinal malignancy? A later look
    • Linos DA, Dozois RR, Dahlin DC, Bartholomew LG. Does Peutz-Jeghers syndrome predispose to gastrointestinal malignancy? A later look. Arch Surg 116: 1182-1184, 1981.
    • (1981) Arch Surg , vol.116 , pp. 1182-1184
    • Linos, D.A.1    Dozois, R.R.2    Dahlin, D.C.3    Bartholomew, L.G.4
  • 78
    • 0037461735 scopus 로고    scopus 로고
    • A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity
    • Martin SG, St Johnston D. A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity. Nature 421: 379-384, 2003.
    • (2003) Nature , vol.421 , pp. 379-384
    • Martin, S.G.1    St Johnston, D.2
  • 80
    • 33749070180 scopus 로고    scopus 로고
    • Peutz-Jeghers syndrome: Clinicopathology and molecular alterations
    • McGarrity TJ, Amos C. Peutz-Jeghers syndrome: clinicopathology and molecular alterations. Cell Mol Life Sci 63: 2135-2144, 2006.
    • (2006) Cell Mol Life Sci , vol.63 , pp. 2135-2144
    • McGarrity, T.J.1    Amos, C.2
  • 81
    • 40949146900 scopus 로고    scopus 로고
    • Normal hypertrophy accompanied by phosphoryation and activation of AMP-activated protein kinase alpha1 following overload in LKB1 knockout mice
    • McGee SL, Mustard KJ, Hardie DG, Baar K. Normal hypertrophy accompanied by phosphoryation and activation of AMP-activated protein kinase alpha1 following overload in LKB1 knockout mice. J Physiol 586: 1731-1741, 2008.
    • (2008) J Physiol , vol.586 , pp. 1731-1741
    • McGee, S.L.1    Mustard, K.J.2    Hardie, D.G.3    Baar, K.4
  • 82
    • 0742270597 scopus 로고    scopus 로고
    • Crystal structure of MO25 alpha in complex with the C terminus of the pseudo kinase STE20-related adaptor
    • Milburn CC, Boudeau J, Deak M, Alessi DR, van Aalten DM. Crystal structure of MO25 alpha in complex with the C terminus of the pseudo kinase STE20-related adaptor. Nature Struct Mol Biol 11: 193-200, 2004.
    • (2004) Nature Struct Mol Biol , vol.11 , pp. 193-200
    • Milburn, C.C.1    Boudeau, J.2    Deak, M.3    Alessi, D.R.4    van Aalten, D.M.5
  • 83
    • 0021079787 scopus 로고
    • Adenocarcinoma of the rectum arising in a hamartomatous polyp in a patient with Peutz-Jeghers syndrome
    • Miller LJ, Bartholomew LG, Dozois RR, Dahlin DC. Adenocarcinoma of the rectum arising in a hamartomatous polyp in a patient with Peutz-Jeghers syndrome. Dig Dis Sci 28: 1047-1051, 1983.
    • (1983) Dig Dis Sci , vol.28 , pp. 1047-1051
    • Miller, L.J.1    Bartholomew, L.G.2    Dozois, R.R.3    Dahlin, D.C.4
  • 86
    • 0026773728 scopus 로고
    • par-4, a gene required for cytoplasmic localization and determination of specific cell types in Caenorhabditis elegans embryogenesis
    • Morton DG, Roos JM, Kemphues KJ. par-4, a gene required for cytoplasmic localization and determination of specific cell types in Caenorhabditis elegans embryogenesis. Genetics 130: 771-790, 1992.
    • (1992) Genetics , vol.130 , pp. 771-790
    • Morton, D.G.1    Roos, J.M.2    Kemphues, K.J.3
  • 87
    • 0037102428 scopus 로고    scopus 로고
    • Hepatocellular carcinoma caused by loss of heterozygosity in Lkb1 gene knockout mice
    • Nakau M, Miyoshi H, Seldin MF, Imamura M, Oshima M, Taketo MM. Hepatocellular carcinoma caused by loss of heterozygosity in Lkb1 gene knockout mice. Cancer Res 62: 4549-4553, 2002.
    • (2002) Cancer Res , vol.62 , pp. 4549-4553
    • Nakau, M.1    Miyoshi, H.2    Seldin, M.F.3    Imamura, M.4    Oshima, M.5    Taketo, M.M.6
  • 93
    • 35348992639 scopus 로고    scopus 로고
    • The genetics of hereditary colon cancer
    • Rustgi AK. The genetics of hereditary colon cancer. Genes Dev 21: 2525-2538, 2007.
    • (2007) Genes Dev , vol.21 , pp. 2525-2538
    • Rustgi, A.K.1
  • 94
    • 17144474893 scopus 로고    scopus 로고
    • Activity of LKB1 and AMPK-related kinases in skeletal muscle: Effects of contraction, phenformin, and AICAR
    • Sakamoto K, Goransson O, Hardie DG, Alessi DR. Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR. Am J Physiol Endocrinol Metab 287: E310-E317, 2004.
    • (2004) Am J Physiol Endocrinol Metab , vol.287
    • Sakamoto, K.1    Goransson, O.2    Hardie, D.G.3    Alessi, D.R.4
  • 95
  • 96
    • 43049128529 scopus 로고    scopus 로고
    • Tenets of PTEN tumor suppression
    • Salmena L, Carracedo A, Pandolfi PP. Tenets of PTEN tumor suppression. Cell 133: 403-414, 2008.
    • (2008) Cell , vol.133 , pp. 403-414
    • Salmena, L.1    Carracedo, A.2    Pandolfi, P.P.3
  • 98
    • 34147152841 scopus 로고    scopus 로고
    • Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade
    • Sanders MJ, Grondin PO, Hegarty BD, Snowden MA, Carling D. Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade. Biochem J 403: 139-148, 2007.
    • (2007) Biochem J , vol.403 , pp. 139-148
    • Sanders, M.J.1    Grondin, P.O.2    Hegarty, B.D.3    Snowden, M.A.4    Carling, D.5
  • 100
    • 0035375261 scopus 로고    scopus 로고
    • Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell growth
    • Sapkota GP, Kieloch A, Lizcano JM, Lain S, Arthur JS, Williams MR, Morrice N, Deak M, Alessi DR. Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell growth. J Biol Chem 276: 19469 -19482, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 19469-19482
    • Sapkota, G.P.1    Kieloch, A.2    Lizcano, J.M.3    Lain, S.4    Arthur, J.S.5    Williams, M.R.6    Morrice, N.7    Deak, M.8    Alessi, D.R.9
  • 102
    • 45549086246 scopus 로고    scopus 로고
    • LKB1 and lung cancer: More than the usual suspects
    • Shah U, Sharpless NE, Hayes DN. LKB1 and lung cancer: more than the usual suspects. Cancer Res 68: 3562-3565, 2008.
    • (2008) Cancer Res , vol.68 , pp. 3562-3565
    • Shah, U.1    Sharpless, N.E.2    Hayes, D.N.3
  • 104
    • 1542618348 scopus 로고    scopus 로고
    • The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
    • Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci USA 101: 3329-3335, 2004.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 3329-3335
    • Shaw, R.J.1    Kosmatka, M.2    Bardeesy, N.3    Hurley, R.L.4    Witters, L.A.5    DePinho, R.A.6    Cantley, L.C.7
  • 106
    • 0023270123 scopus 로고
    • Epithelial misplacement in Peutz-Jeghers polyps. A diagnostic pitfall
    • Shepherd NA, Bussey HJ, Jass JR. Epithelial misplacement in Peutz-Jeghers polyps. A diagnostic pitfall. Am J Surg Pathol 11: 743-749, 1987.
    • (1987) Am J Surg Pathol , vol.11 , pp. 743-749
    • Shepherd, N.A.1    Bussey, H.J.2    Jass, J.R.3
  • 107
    • 33845616760 scopus 로고    scopus 로고
    • Histopathological mimicry in mucosal prolapse
    • Singh B, Mortensen NJ, Warren BF. Histopathological mimicry in mucosal prolapse. Histopathology 50: 97-102, 2007.
    • (2007) Histopathology , vol.50 , pp. 97-102
    • Singh, B.1    Mortensen, N.J.2    Warren, B.F.3
  • 108
    • 0032815880 scopus 로고    scopus 로고
    • The mouse Peutz-Jeghers syndrome gene Lkb1 encodes a nuclear protein kinase
    • Smith DP, Spicer J, Smith A, Swift S, Ashworth A. The mouse Peutz-Jeghers syndrome gene Lkb1 encodes a nuclear protein kinase. Hum Mol Genet 8: 1479-1485, 1999.
    • (1999) Hum Mol Genet , vol.8 , pp. 1479-1485
    • Smith, D.P.1    Spicer, J.2    Smith, A.3    Swift, S.4    Ashworth, A.5
  • 109
    • 45549094869 scopus 로고    scopus 로고
    • Protein kinase C zeta-dependent LKB1 serine 428 phosphorylation increases LKB1 nucleus export and apoptosis in endothelial cells
    • Song P, Xie Z, Wu Y, Xu J, Dong Y, Zou MH. Protein kinase C zeta-dependent LKB1 serine 428 phosphorylation increases LKB1 nucleus export and apoptosis in endothelial cells. J Biol Chem 283: 12446-12455, 2008.
    • (2008) J Biol Chem , vol.283 , pp. 12446-12455
    • Song, P.1    Xie, Z.2    Wu, Y.3    Xu, J.4    Dong, Y.5    Zou, M.H.6
  • 110
    • 0042090214 scopus 로고    scopus 로고
    • Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1
    • Spicer J, Rayter S, Young N, Elliott R, Ashworth A, Smith D. Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1. Oncogene 22: 4752- 4756, 2003.
    • (2003) Oncogene , vol.22 , pp. 4752-4756
    • Spicer, J.1    Rayter, S.2    Young, N.3    Elliott, R.4    Ashworth, A.5    Smith, D.6
  • 112
    • 33845949733 scopus 로고    scopus 로고
    • Dissecting the role of 5′-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase
    • Suter M, Riek U, Tuerk R, Schlattner U, Wallimann T, Neumann D. Dissecting the role of 5′-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase. J Biol Chem 281: 32207-32216, 2006.
    • (2006) J Biol Chem , vol.281 , pp. 32207-32216
    • Suter, M.1    Riek, U.2    Tuerk, R.3    Schlattner, U.4    Wallimann, T.5    Neumann, D.6
  • 114
    • 34250182374 scopus 로고    scopus 로고
    • Leptin stimulates fatty acid oxidation and peroxisome proliferator-activated receptor alpha gene expression in mouse C2C12 myoblasts by changing the subcellular localization of the alpha2 form of AMP-activated protein kinase
    • Suzuki A, Okamoto S, Lee S, Saito K, Shiuchi T, Minokoshi Y. Leptin stimulates fatty acid oxidation and peroxisome proliferator-activated receptor alpha gene expression in mouse C2C12 myoblasts by changing the subcellular localization of the alpha2 form of AMP-activated protein kinase. Mol Cell Biol 27: 4317-4327, 2007.
    • (2007) Mol Cell Biol , vol.27 , pp. 4317-4327
    • Suzuki, A.1    Okamoto, S.2    Lee, S.3    Saito, K.4    Shiuchi, T.5    Minokoshi, Y.6
  • 116
    • 33645022897 scopus 로고    scopus 로고
    • Accelerated onsets of gastric hamartomas and hepatic adenomas/carcinomas in Lkb1+/-p53-/- compound mutant mice
    • Takeda H, Miyoshi H, Kojima Y, Oshima M, Taketo MM. Accelerated onsets of gastric hamartomas and hepatic adenomas/carcinomas in Lkb1+/-p53-/- compound mutant mice. Oncogene 25: 1816-1820, 2006.
    • (2006) Oncogene , vol.25 , pp. 1816-1820
    • Takeda, H.1    Miyoshi, H.2    Kojima, Y.3    Oshima, M.4    Taketo, M.M.5
  • 118
    • 41649083427 scopus 로고    scopus 로고
    • Lgl and its phosphorylation by aPKC regulate oocyte polarity formation in Drosophila
    • Tian AG, Deng WM. Lgl and its phosphorylation by aPKC regulate oocyte polarity formation in Drosophila. Development 135: 463-471, 2008.
    • (2008) Development , vol.135 , pp. 463-471
    • Tian, A.G.1    Deng, W.M.2
  • 119
    • 0141530895 scopus 로고    scopus 로고
    • Timm T, Li XY, Biernat J, Jiao J, Mandelkow E, Vandekerckhove J, Mandelkow EM. MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1. EMBO J 22: 5090-5101, 2003.
    • Timm T, Li XY, Biernat J, Jiao J, Mandelkow E, Vandekerckhove J, Mandelkow EM. MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1. EMBO J 22: 5090-5101, 2003.
  • 121
    • 33847080728 scopus 로고    scopus 로고
    • AMP-activated protein kinase in metabolic control and insulin signaling
    • Towler MC, Hardie DG. AMP-activated protein kinase in metabolic control and insulin signaling. Circ Res 100: 328-341, 2007.
    • (2007) Circ Res , vol.100 , pp. 328-341
    • Towler, M.C.1    Hardie, D.G.2
  • 122
    • 0033915012 scopus 로고    scopus 로고
    • 5′-CpG island methylation of the LKB1/STK11 promoter and allelic loss at chromosome 19p13.3 in sporadic colorectal cancer
    • Trojan J, Brieger A, Raedle J, Esteller M, Zeuzem S. 5′-CpG island methylation of the LKB1/STK11 promoter and allelic loss at chromosome 19p13.3 in sporadic colorectal cancer. Gut 47: 272-276, 2000.
    • (2000) Gut , vol.47 , pp. 272-276
    • Trojan, J.1    Brieger, A.2    Raedle, J.3    Esteller, M.4    Zeuzem, S.5
  • 126
    • 0034090975 scopus 로고    scopus 로고
    • The C. elegans par-4 gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetry
    • Watts JL, Morton DG, Bestman J, Kemphues KJ. The C. elegans par-4 gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetry. Development 127: 1467-1475, 2000.
    • (2000) Development , vol.127 , pp. 1467-1475
    • Watts, J.L.1    Morton, D.G.2    Bestman, J.3    Kemphues, K.J.4
  • 130
    • 34247475176 scopus 로고    scopus 로고
    • BDNF instructs the kinase LKB1 to grow an axon
    • Winckler B. BDNF instructs the kinase LKB1 to grow an axon. Cell 129: 459-460, 2007.
    • (2007) Cell , vol.129 , pp. 459-460
    • Winckler, B.1
  • 133
    • 37549065556 scopus 로고    scopus 로고
    • The GC kinase Fray and Mo25 regulate Drosophila asymmetric divisions
    • Yamamoto Y, Izumi Y, Matsuzaki F. The GC kinase Fray and Mo25 regulate Drosophila asymmetric divisions. Biochem Biophys Res Commun 366: 212-218, 2008.
    • (2008) Biochem Biophys Res Commun , vol.366 , pp. 212-218
    • Yamamoto, Y.1    Izumi, Y.2    Matsuzaki, F.3
  • 135
    • 13244258315 scopus 로고    scopus 로고
    • Sex cord-stromal tumors of the ovary and testis: Their similarities and differences with consideration of selected problems
    • Young RH. Sex cord-stromal tumors of the ovary and testis: their similarities and differences with consideration of selected problems. Mod Pathol 18 Suppl 2: S81-98, 2005.
    • (2005) Mod Pathol , vol.18 , Issue.SUPPL. 2
    • Young, R.H.1
  • 136
    • 33751204464 scopus 로고    scopus 로고
    • AMP-activated protein kinase regulates the assembly of epithelial tight junctions
    • Zhang L, Li J, Young LH, Caplan MJ. AMP-activated protein kinase regulates the assembly of epithelial tight junctions. Proc Natl Acad Sci USA 103: 17272-17277, 2006.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 17272-17277
    • Zhang, L.1    Li, J.2    Young, L.H.3    Caplan, M.J.4
  • 137
    • 38849204971 scopus 로고    scopus 로고
    • The tumor suppressor LKB1 regulates lung cancer cell polarity by mediating cdc42 recruitment and activity
    • Zhang S, Schafer-Hales K, Khuri FR, Zhou W, Vertino PM, Marcus AI. The tumor suppressor LKB1 regulates lung cancer cell polarity by mediating cdc42 recruitment and activity. Cancer Res 68: 740-748, 2008.
    • (2008) Cancer Res , vol.68 , pp. 740-748
    • Zhang, S.1    Schafer-Hales, K.2    Khuri, F.R.3    Zhou, W.4    Vertino, P.M.5    Marcus, A.I.6
  • 138
    • 33846521353 scopus 로고    scopus 로고
    • Regulation of epithelial tight junction assembly and disassembly by AMP-activated protein kinase
    • Zheng B, Cantley LC. Regulation of epithelial tight junction assembly and disassembly by AMP-activated protein kinase. Proc Natl Acad Sci USA 104: 819-822, 2007.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 819-822
    • Zheng, B.1    Cantley, L.C.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.