-
2
-
-
20244372563
-
Mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRADalpha, and MO25alpha, in Peutz-Jeghers syndrome
-
Alhopuro P, Katajisto P, Lehtonen R, Ylisaukko-Oja SK, Naatsaari L, Karhu A, Westerman AM, Wilson JH, de Rooij FW, Vogel T, Moeslein G, Tomlinson IP, Aaltonen LA, Makela TP, Launonen V. Mutation analysis of three genes encoding novel LKB1-interacting proteins, BRG1, STRADalpha, and MO25alpha, in Peutz-Jeghers syndrome. Br J Cancer 92: 1126-1129, 2005.
-
(2005)
Br J Cancer
, vol.92
, pp. 1126-1129
-
-
Alhopuro, P.1
Katajisto, P.2
Lehtonen, R.3
Ylisaukko-Oja, S.K.4
Naatsaari, L.5
Karhu, A.6
Westerman, A.M.7
Wilson, J.H.8
de Rooij, F.W.9
Vogel, T.10
Moeslein, G.11
Tomlinson, I.P.12
Aaltonen, L.A.13
Makela, T.P.14
Launonen, V.15
-
3
-
-
44449178672
-
Unregulated smooth-muscle myosin in human intestinal neoplasia
-
Alhopuro P, Phichith D, Tuupanen S, Sammalkorpi H, Nybondas M, Saharinen J, Robinson JP, Yang Z, Chen LQ, Orntoft T, Mecklin JP, Jarvinen H, Eng C, Moeslein G, Shibata D, Houlston RS, Lucassen A, Tomlinson IP, Launonen V, Ristimaki A, Arango D, Karhu A, Sweeney HL, Aaltonen LA. Unregulated smooth-muscle myosin in human intestinal neoplasia. Proc Natl Acad Sci USA 105: 5513-5518, 2008.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 5513-5518
-
-
Alhopuro, P.1
Phichith, D.2
Tuupanen, S.3
Sammalkorpi, H.4
Nybondas, M.5
Saharinen, J.6
Robinson, J.P.7
Yang, Z.8
Chen, L.Q.9
Orntoft, T.10
Mecklin, J.P.11
Jarvinen, H.12
Eng, C.13
Moeslein, G.14
Shibata, D.15
Houlston, R.S.16
Lucassen, A.17
Tomlinson, I.P.18
Launonen, V.19
Ristimaki, A.20
Arango, D.21
Karhu, A.22
Sweeney, H.L.23
Aaltonen, L.A.24
more..
-
4
-
-
33947526130
-
AMP-activated protein kinase in the heart: Role during health and disease
-
Arad M, Seidman CE, Seidman JG. AMP-activated protein kinase in the heart: role during health and disease. Circ Res 100: 474-488, 2007.
-
(2007)
Circ Res
, vol.100
, pp. 474-488
-
-
Arad, M.1
Seidman, C.E.2
Seidman, J.G.3
-
5
-
-
28844507521
-
High proportion of large genomic STK11 deletions in Peutz-Jeghers syndrome
-
Aretz S, Stienen D, Uhlhaas S, Loff S, Back W, Pagenstecher C, McLeod DR, Graham GE, Mangold E, Santer R, Propping P, Friedl W. High proportion of large genomic STK11 deletions in Peutz-Jeghers syndrome. Hum Mutat 26: 513-519, 2005.
-
(2005)
Hum Mutat
, vol.26
, pp. 513-519
-
-
Aretz, S.1
Stienen, D.2
Uhlhaas, S.3
Loff, S.4
Back, W.5
Pagenstecher, C.6
McLeod, D.R.7
Graham, G.E.8
Mangold, E.9
Santer, R.10
Propping, P.11
Friedl, W.12
-
6
-
-
0038614742
-
Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD
-
Baas AF, Boudeau J, Sapkota GP, Smit L, Medema R, Morrice NA, Alessi DR, Clevers HC. Activation of the tumour suppressor kinase LKB1 by the STE20-like pseudokinase STRAD. EMBO J 22: 3062-3072, 2003.
-
(2003)
EMBO J
, vol.22
, pp. 3062-3072
-
-
Baas, A.F.1
Boudeau, J.2
Sapkota, G.P.3
Smit, L.4
Medema, R.5
Morrice, N.A.6
Alessi, D.R.7
Clevers, H.C.8
-
7
-
-
1542777034
-
Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD
-
Baas AF, Kuipers J, van der Wel NN, Batlle E, Koerten HK, Peters PJ, Clevers HC. Complete polarization of single intestinal epithelial cells upon activation of LKB1 by STRAD. Cell 116: 457-466, 2004.
-
(2004)
Cell
, vol.116
, pp. 457-466
-
-
Baas, A.F.1
Kuipers, J.2
van der Wel, N.N.3
Batlle, E.4
Koerten, H.K.5
Peters, P.J.6
Clevers, H.C.7
-
8
-
-
36549040859
-
The selectivity of protein kinase inhibitors: A further update
-
Bain J, Plater L, Elliott M, Shpiro N, Hastie CJ, McLauchlan H, Klevernic I, Arthur JS, Alessi DR, Cohen P. The selectivity of protein kinase inhibitors: a further update. Biochem J 408: 297-315, 2007.
-
(2007)
Biochem J
, vol.408
, pp. 297-315
-
-
Bain, J.1
Plater, L.2
Elliott, M.3
Shpiro, N.4
Hastie, C.J.5
McLauchlan, H.6
Klevernic, I.7
Arthur, J.S.8
Alessi, D.R.9
Cohen, P.10
-
9
-
-
0037068461
-
Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation
-
Bardeesy N, Sinha M, Hezel AF, Signoretti S, Hathaway NA, Sharpless NE, Loda M, Carrasco DR, DePinho RA. Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation. Nature 419: 162-167, 2002.
-
(2002)
Nature
, vol.419
, pp. 162-167
-
-
Bardeesy, N.1
Sinha, M.2
Hezel, A.F.3
Signoretti, S.4
Hathaway, N.A.5
Sharpless, N.E.6
Loda, M.7
Carrasco, D.R.8
DePinho, R.A.9
-
11
-
-
35548974423
-
Identification of stem cells in small intestine and colon by marker gene Lgr5
-
Barker N, van Es JH, Kuipers J, Kujala P, van den Born M, Cozijnsen M, Haegebarth A, Korving J, Begthel H, Peters PJ, Clevers H. Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature 449: 1003-1007, 2007.
-
(2007)
Nature
, vol.449
, pp. 1003-1007
-
-
Barker, N.1
van Es, J.H.2
Kuipers, J.3
Kujala, P.4
van den Born, M.5
Cozijnsen, M.6
Haegebarth, A.7
Korving, J.8
Begthel, H.9
Peters, P.J.10
Clevers, H.11
-
12
-
-
34247511497
-
LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons
-
Barnes AP, Lilley BN, Pan YA, Plummer LJ, Powell AW, Raines AN, Sanes JR, Polleux F. LKB1 and SAD kinases define a pathway required for the polarization of cortical neurons. Cell 129: 549-563, 2007.
-
(2007)
Cell
, vol.129
, pp. 549-563
-
-
Barnes, A.P.1
Lilley, B.N.2
Pan, Y.A.3
Plummer, L.J.4
Powell, A.W.5
Raines, A.N.6
Sanes, J.R.7
Polleux, F.8
-
13
-
-
0347596668
-
Drosophila PAR-1 and 14-3-3 inhibit Bazooka/PAR-3 to establish complementary cortical domains in polarized cells
-
Benton R, St Johnston D. Drosophila PAR-1 and 14-3-3 inhibit Bazooka/PAR-3 to establish complementary cortical domains in polarized cells. Cell 115: 691-704, 2003.
-
(2003)
Cell
, vol.115
, pp. 691-704
-
-
Benton, R.1
St Johnston, D.2
-
14
-
-
4344648897
-
Dare to be different: Asymmetric cell division in Drosophila, C. elegans, and vertebrates
-
Betschinger J, Knoblich JA. Dare to be different: asymmetric cell division in Drosophila, C. elegans, and vertebrates. Curr Biol 14: R674-685, 2004.
-
(2004)
Curr Biol
, vol.14
-
-
Betschinger, J.1
Knoblich, J.A.2
-
15
-
-
0036854327
-
Protein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity
-
Biernat J, Wu YZ, Timm T, Zheng-Fischhofer Q, Mandelkow E, Meijer L, Mandelkow EM. Protein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity. Mol Biol Cell 13: 4013-4028, 2002.
-
(2002)
Mol Biol Cell
, vol.13
, pp. 4013-4028
-
-
Biernat, J.1
Wu, Y.Z.2
Timm, T.3
Zheng-Fischhofer, Q.4
Mandelkow, E.5
Meijer, L.6
Mandelkow, E.M.7
-
16
-
-
34250844968
-
The Drosophila Lkb1 kinase is required for spindle formation and asymmetric neuroblast division
-
Bonaccorsi S, Mottier V, Giansanti MG, Bolkan BJ, Williams B, Goldberg ML, Gatti M. The Drosophila Lkb1 kinase is required for spindle formation and asymmetric neuroblast division. Development 134: 2183-2193, 2007.
-
(2007)
Development
, vol.134
, pp. 2183-2193
-
-
Bonaccorsi, S.1
Mottier, V.2
Giansanti, M.G.3
Bolkan, B.J.4
Williams, B.5
Goldberg, M.L.6
Gatti, M.7
-
17
-
-
0032946456
-
The hamartoma-adenoma-carcinoma sequence
-
Bosman FT. The hamartoma-adenoma-carcinoma sequence. J Pathol 188: 1-2, 1999.
-
(1999)
J Pathol
, vol.188
, pp. 1-2
-
-
Bosman, F.T.1
-
18
-
-
0141753981
-
-
Boudeau J, Baas AF, Deak M, Morrice NA, Kieloch A, Schutkowski M, Prescott AR, Clevers HC, Alessi DR. MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. EMBO J 22: 5102-5114, 2003.
-
Boudeau J, Baas AF, Deak M, Morrice NA, Kieloch A, Schutkowski M, Prescott AR, Clevers HC, Alessi DR. MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm. EMBO J 22: 5102-5114, 2003.
-
-
-
-
19
-
-
33747886526
-
Emerging roles of pseudokinases
-
Boudeau J, Miranda-Saavedra D, Barton GJ, Alessi DR. Emerging roles of pseudokinases. Trends Cell Biol 16: 443-452, 2006.
-
(2006)
Trends Cell Biol
, vol.16
, pp. 443-452
-
-
Boudeau, J.1
Miranda-Saavedra, D.2
Barton, G.J.3
Alessi, D.R.4
-
20
-
-
13444293128
-
Analysis of the LKB1-STRAD-MO25 complex
-
Boudeau J, Scott JW, Resta N, Deak M, Kieloch A, Komander D, Hardie DG, Prescott AR, van Aalten DM, Alessi DR. Analysis of the LKB1-STRAD-MO25 complex. J Cell Sci 117: 6365-6375, 2004.
-
(2004)
J Cell Sci
, vol.117
, pp. 6365-6375
-
-
Boudeau, J.1
Scott, J.W.2
Resta, N.3
Deak, M.4
Kieloch, A.5
Komander, D.6
Hardie, D.G.7
Prescott, A.R.8
van Aalten, D.M.9
Alessi, D.R.10
-
21
-
-
33645766204
-
Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin
-
Bowker SL, Majumdar SR, Veugelers P, Johnson JA. Increased cancer-related mortality for patients with type 2 diabetes who use sulfonylureas or insulin. Diabetes Care 29: 254-258, 2006.
-
(2006)
Diabetes Care
, vol.29
, pp. 254-258
-
-
Bowker, S.L.1
Majumdar, S.R.2
Veugelers, P.3
Johnson, J.A.4
-
22
-
-
1842581909
-
Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network
-
Brajenovic M, Joberty G, Kuster B, Bouwmeester T, Drewes G. Comprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein network. J Biol Chem 279: 12804-12811, 2004.
-
(2004)
J Biol Chem
, vol.279
, pp. 12804-12811
-
-
Brajenovic, M.1
Joberty, G.2
Kuster, B.3
Bouwmeester, T.4
Drewes, G.5
-
23
-
-
33847314077
-
Gastrointestinal polyposis syndromes
-
Brosens LA, van Hattem WA, Jansen M, de Leng WW, Giardiello FM, Offerhaus GJ. Gastrointestinal polyposis syndromes. Curr Mol Med 7: 29-46, 2007.
-
(2007)
Curr Mol Med
, vol.7
, pp. 29-46
-
-
Brosens, L.A.1
van Hattem, W.A.2
Jansen, M.3
de Leng, W.W.4
Giardiello, F.M.5
Offerhaus, G.J.6
-
24
-
-
3142587052
-
Dysregulation of HIF and VEGF is a unifying feature of the familial hamartoma syndromes
-
Brugarolas J, Kaelin WG Jr. Dysregulation of HIF and VEGF is a unifying feature of the familial hamartoma syndromes. Cancer Cell 6: 7-10, 2004.
-
(2004)
Cancer Cell
, vol.6
, pp. 7-10
-
-
Brugarolas, J.1
Kaelin Jr., W.G.2
-
25
-
-
33744781836
-
Microtubule affinity-regulating kinase 2 functions downstream of the PAR-3/PAR-6/atypical PKC complex in regulating hippocampal neuronal polarity
-
Chen YM, Wang QJ, Hu HS, Yu PC, Zhu J, Drewes G, Piwnica-Worms H, Luo ZG. Microtubule affinity-regulating kinase 2 functions downstream of the PAR-3/PAR-6/atypical PKC complex in regulating hippocampal neuronal polarity. Proc Natl Acad Sci USA 103: 8534-8539, 2006.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 8534-8539
-
-
Chen, Y.M.1
Wang, Q.J.2
Hu, H.S.3
Yu, P.C.4
Zhu, J.5
Drewes, G.6
Piwnica-Worms, H.7
Luo, Z.G.8
-
26
-
-
0034141636
-
LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo
-
Collins SP, Reoma JL, Gamm DM, Uhler MD. LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo. Biochem J 345: 673-680, 2000.
-
(2000)
Biochem J
, vol.345
, pp. 673-680
-
-
Collins, S.P.1
Reoma, J.L.2
Gamm, D.M.3
Uhler, M.D.4
-
27
-
-
38849193504
-
Loss of Lkb1 provokes highly invasive endometrial adenocarcinomas
-
Contreras CM, Gurumurthy S, Haynie JM, Shirley LJ, Akbay EA, Wingo SN, Schorge JO, Broaddus RR, Wong KK, Bardeesy N, Castrillon DH. Loss of Lkb1 provokes highly invasive endometrial adenocarcinomas. Cancer Res 68: 759-766, 2008.
-
(2008)
Cancer Res
, vol.68
, pp. 759-766
-
-
Contreras, C.M.1
Gurumurthy, S.2
Haynie, J.M.3
Shirley, L.J.4
Akbay, E.A.5
Wingo, S.N.6
Schorge, J.O.7
Broaddus, R.R.8
Wong, K.K.9
Bardeesy, N.10
Castrillon, D.H.11
-
28
-
-
34247338972
-
Acto-myosin reorganization and PAR polarity in C. elegans
-
Cowan CR, Hyman AA. Acto-myosin reorganization and PAR polarity in C. elegans. Development 134: 1035-1043, 2007.
-
(2007)
Development
, vol.134
, pp. 1035-1043
-
-
Cowan, C.R.1
Hyman, A.A.2
-
29
-
-
36248948056
-
Genetic defects underlying Peutz-Jeghers syndrome (PJS) and exclusion of the polarity-associated MARK/Par1 gene family as potential PJS candidates
-
De Leng WW, Jansen M, Carvalho R, Polak M, Musler AR, Milne AN, Keller JJ, Menko FH, de Rooij FW, Iacobuzio-Donahue CA, Giardiello FM, Weterman MA, Offerhaus GJ. Genetic defects underlying Peutz-Jeghers syndrome (PJS) and exclusion of the polarity-associated MARK/Par1 gene family as potential PJS candidates. Clin Genet 72: 568-573, 2007.
-
(2007)
Clin Genet
, vol.72
, pp. 568-573
-
-
De Leng, W.W.1
Jansen, M.2
Carvalho, R.3
Polak, M.4
Musler, A.R.5
Milne, A.N.6
Keller, J.J.7
Menko, F.H.8
de Rooij, F.W.9
Iacobuzio-Donahue, C.A.10
Giardiello, F.M.11
Weterman, M.A.12
Offerhaus, G.J.13
-
30
-
-
34948868190
-
Peutz-Jeghers syndrome polyps are polyclonal with expanded progenitor cell compartment
-
De Leng WW, Jansen M, Keller JJ, de Gijsel M, Milne AN, Morsink FH, Weterman MA, Iacobuzio-Donahue CA, Clevers HC, Giardiello FM, Offerhaus GJ. Peutz-Jeghers syndrome polyps are polyclonal with expanded progenitor cell compartment. Gut 56: 1475-1476, 2007.
-
(2007)
Gut
, vol.56
, pp. 1475-1476
-
-
De Leng, W.W.1
Jansen, M.2
Keller, J.J.3
de Gijsel, M.4
Milne, A.N.5
Morsink, F.H.6
Weterman, M.A.7
Iacobuzio-Donahue, C.A.8
Clevers, H.C.9
Giardiello, F.M.10
Offerhaus, G.J.11
-
31
-
-
26244445827
-
-
De Leng WW, Keller JJ, Luiten S, Musler AR, Jansen M, Baas AF, de Rooij FW, Gille JJ, Menko FH, Offerhaus GJ, Weterman MA. STRAD in Peutz-Jeghers syndrome and sporadic cancers. J Clin Pathol 58: 1091-1095, 2005.
-
De Leng WW, Keller JJ, Luiten S, Musler AR, Jansen M, Baas AF, de Rooij FW, Gille JJ, Menko FH, Offerhaus GJ, Weterman MA. STRAD in Peutz-Jeghers syndrome and sporadic cancers. J Clin Pathol 58: 1091-1095, 2005.
-
-
-
-
32
-
-
58649094677
-
Characterization of an alternative splice variant of LKB1
-
Denison FC, Hiscock NJ, Carling D, Woods A. Characterization of an alternative splice variant of LKB1. J Biol Chem 284: 67-76, 2009.
-
(2009)
J Biol Chem
, vol.284
, pp. 67-76
-
-
Denison, F.C.1
Hiscock, N.J.2
Carling, D.3
Woods, A.4
-
33
-
-
44949122687
-
STRADα regulates LKB1 localization by blocking access to importin-α, and by association with Crm1 and Exportin-7
-
Dorfman J, Macara IG. STRADα regulates LKB1 localization by blocking access to importin-α, and by association with Crm1 and Exportin-7. Mol Biol Cell 19: 1614-1626, 2008.
-
(2008)
Mol Biol Cell
, vol.19
, pp. 1614-1626
-
-
Dorfman, J.1
Macara, I.G.2
-
34
-
-
0031684636
-
MAPs, MARKs and microtubule dynamics
-
Drewes G, Ebneth A, Mandelkow EM. MAPs, MARKs and microtubule dynamics. Trends Biochem Sci 23: 307-311, 1998.
-
(1998)
Trends Biochem Sci
, vol.23
, pp. 307-311
-
-
Drewes, G.1
Ebneth, A.2
Mandelkow, E.M.3
-
35
-
-
20444461067
-
Metformin and reduced risk of cancer in diabetic patients
-
Evans JM, Donnelly LA, Emslie-Smith AM, Alessi DR, Morris AD. Metformin and reduced risk of cancer in diabetic patients. BMJ 330: 1304-1305, 2005.
-
(2005)
BMJ
, vol.330
, pp. 1304-1305
-
-
Evans, J.M.1
Donnelly, L.A.2
Emslie-Smith, A.M.3
Alessi, D.R.4
Morris, A.D.5
-
37
-
-
35549001736
-
The PAR proteins: Fundamental players in animal cell polarization
-
Goldstein B, Macara IG. The PAR proteins: fundamental players in animal cell polarization. Dev Cell 13: 609-622, 2007.
-
(2007)
Dev Cell
, vol.13
, pp. 609-622
-
-
Goldstein, B.1
Macara, I.G.2
-
38
-
-
33750457625
-
Regulation of the polarity kinases PAR-1/MARK by 14-3-3 interaction and phosphorylation
-
Goransson O, Deak M, Wullschleger S, Morrice NA, Prescott AR, Alessi DR. Regulation of the polarity kinases PAR-1/MARK by 14-3-3 interaction and phosphorylation. J Cell Sci 119: 4059-4070, 2006.
-
(2006)
J Cell Sci
, vol.119
, pp. 4059-4070
-
-
Goransson, O.1
Deak, M.2
Wullschleger, S.3
Morrice, N.A.4
Prescott, A.R.5
Alessi, D.R.6
-
39
-
-
39149083762
-
LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis
-
Gurumurthy S, Hezel AF, Berger JH, Bosenberg MW, Bardeesy N. LKB1 deficiency sensitizes mice to carcinogen-induced tumorigenesis. Cancer Res 68: 55-63, 2008.
-
(2008)
Cancer Res
, vol.68
, pp. 55-63
-
-
Gurumurthy, S.1
Hezel, A.F.2
Berger, J.H.3
Bosenberg, M.W.4
Bardeesy, N.5
-
40
-
-
42949139481
-
AMPK phosphorylation of raptor mediates a metabolic checkpoint
-
Gwinn DM, Shackelford DB, Egan DF, Mihaylova MM, Mery A, Vasquez DS, Turk BE, Shaw RJ. AMPK phosphorylation of raptor mediates a metabolic checkpoint. Mol Cell 30: 214-226, 2008.
-
(2008)
Mol Cell
, vol.30
, pp. 214-226
-
-
Gwinn, D.M.1
Shackelford, D.B.2
Egan, D.F.3
Mihaylova, M.M.4
Mery, A.5
Vasquez, D.S.6
Turk, B.E.7
Shaw, R.J.8
-
41
-
-
34648828532
-
AMP-activated/SNF1 protein kinases: Conserved guardians of cellular energy
-
Hardie DG. AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. Nature Rev 8: 774-785, 2007.
-
(2007)
Nature Rev
, vol.8
, pp. 774-785
-
-
Hardie, D.G.1
-
42
-
-
0345107247
-
Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade
-
Hawley SA, Boudeau J, Reid JL, Mustard KJ, Udd L, Makela TP, Alessi DR, Hardie DG. Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade. J Biol 2: 28, 2003.
-
(2003)
J Biol
, vol.2
, pp. 28
-
-
Hawley, S.A.1
Boudeau, J.2
Reid, J.L.3
Mustard, K.J.4
Udd, L.5
Makela, T.P.6
Alessi, D.R.7
Hardie, D.G.8
-
43
-
-
33744782567
-
Frequency and spectrum of cancers in the Peutz-Jeghers syndrome
-
Hearle N, Schumacher V, Menko FH, Olschwang S, Boardman LA, Gille JJ, Keller JJ, Westerman AM, Scott RJ, Lim W, Trimbath JD, Giardiello FM, Gruber SB, Offerhaus GJ, de Rooij FW, Wilson JH, Hansmann A, Moslein G, Royer-Pokora B, Vogel T, Phillips RK, Spigelman AD, Houlston RS. Frequency and spectrum of cancers in the Peutz-Jeghers syndrome. Clin Cancer Res 12: 3209-3215, 2006.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 3209-3215
-
-
Hearle, N.1
Schumacher, V.2
Menko, F.H.3
Olschwang, S.4
Boardman, L.A.5
Gille, J.J.6
Keller, J.J.7
Westerman, A.M.8
Scott, R.J.9
Lim, W.10
Trimbath, J.D.11
Giardiello, F.M.12
Gruber, S.B.13
Offerhaus, G.J.14
de Rooij, F.W.15
Wilson, J.H.16
Hansmann, A.17
Moslein, G.18
Royer-Pokora, B.19
Vogel, T.20
Phillips, R.K.21
Spigelman, A.D.22
Houlston, R.S.23
more..
-
44
-
-
33744828352
-
Exonic STK11 deletions are not a rare cause of Peutz-Jeghers syndrome
-
Hearle NC, Rudd MF, Lim W, Murday V, Lim AG, Phillips RK, Lee PW, O'Donohue J, Morrison PJ, Norman A, Hodgson SV, Lucassen A, Houlston RS. Exonic STK11 deletions are not a rare cause of Peutz-Jeghers syndrome. J Med Genet 43: e15, 2006.
-
(2006)
J Med Genet
, vol.43
-
-
Hearle, N.C.1
Rudd, M.F.2
Lim, W.3
Murday, V.4
Lim, A.G.5
Phillips, R.K.6
Lee, P.W.7
O'Donohue, J.8
Morrison, P.J.9
Norman, A.10
Hodgson, S.V.11
Lucassen, A.12
Houlston, R.S.13
-
45
-
-
0032495530
-
A serine/threonine kinase gene defective in Peutz-Jeghers syndrome
-
Hemminki A, Markie D, Tomlinson I, Avizienyte E, Roth S, Loukola A, Bignell G, Warren W, Aminoff M, Hoglund P, Jarvinen H, Kristo P, Pelin K, Ridanpaa M, Salovaara R, Toro T, Bodmer W, Olschwang S, Olsen AS, Stratton MR, de la Chapelle A, Aaltonen LA. A serine/threonine kinase gene defective in Peutz-Jeghers syndrome. Nature 391: 184-187, 1998.
-
(1998)
Nature
, vol.391
, pp. 184-187
-
-
Hemminki, A.1
Markie, D.2
Tomlinson, I.3
Avizienyte, E.4
Roth, S.5
Loukola, A.6
Bignell, G.7
Warren, W.8
Aminoff, M.9
Hoglund, P.10
Jarvinen, H.11
Kristo, P.12
Pelin, K.13
Ridanpaa, M.14
Salovaara, R.15
Toro, T.16
Bodmer, W.17
Olschwang, S.18
Olsen, A.S.19
Stratton, M.R.20
de la Chapelle, A.21
Aaltonen, L.A.22
more..
-
46
-
-
0031012344
-
Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis
-
Hemminki A, Tomlinson I, Markie D, Jarvinen H, Sistonen P, Bjorkqvist AM, Knuutila S, Salovaara R, Bodmer W, Shibata D, de la Chapelle A, Aaltonen LA. Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis. Nature Genet 15: 87-90, 1997.
-
(1997)
Nature Genet
, vol.15
, pp. 87-90
-
-
Hemminki, A.1
Tomlinson, I.2
Markie, D.3
Jarvinen, H.4
Sistonen, P.5
Bjorkqvist, A.M.6
Knuutila, S.7
Salovaara, R.8
Bodmer, W.9
Shibata, D.10
de la Chapelle, A.11
Aaltonen, L.A.12
-
47
-
-
3242662786
-
De novo germline mutation in the serine-threonine kinase STK11/LKB1 gene associated with Peutz-Jeghers syndrome
-
Hernan I, Roig I, Martin B, Gamundi MJ, Martinez-Gimeno M, Carballo M. De novo germline mutation in the serine-threonine kinase STK11/LKB1 gene associated with Peutz-Jeghers syndrome. Clin Genet 66: 58-62, 2004.
-
(2004)
Clin Genet
, vol.66
, pp. 58-62
-
-
Hernan, I.1
Roig, I.2
Martin, B.3
Gamundi, M.J.4
Martinez-Gimeno, M.5
Carballo, M.6
-
48
-
-
39749194712
-
Pancreatic lkb1 deletion leads to acinar polarity defects and cystic neoplasms
-
Hezel AF, Gurumurthy S, Granot Z, Swisa A, Chu GC, Bailey G, Dor Y, Bardeesy N, Depinho RA. Pancreatic lkb1 deletion leads to acinar polarity defects and cystic neoplasms. Mol Cell Biol 28: 2414-2425, 2008.
-
(2008)
Mol Cell Biol
, vol.28
, pp. 2414-2425
-
-
Hezel, A.F.1
Gurumurthy, S.2
Granot, Z.3
Swisa, A.4
Chu, G.C.5
Bailey, G.6
Dor, Y.7
Bardeesy, N.8
Depinho, R.A.9
-
49
-
-
49649085586
-
AMP-activated protein kinase phosphorylates and desensitizes smooth muscle myosin light chain kinase
-
Horman S, Morel N, Vertommen D, Hussain N, Neumann D, Beauloye C, El Najjar N, Forcet C, Viollet B, Walsh MP, Hue L, Rider MH. AMP-activated protein kinase phosphorylates and desensitizes smooth muscle myosin light chain kinase. J Biol Chem 283: 18505-18512, 2008.
-
(2008)
J Biol Chem
, vol.283
, pp. 18505-18512
-
-
Horman, S.1
Morel, N.2
Vertommen, D.3
Hussain, N.4
Neumann, D.5
Beauloye, C.6
El Najjar, N.7
Forcet, C.8
Viollet, B.9
Walsh, M.P.10
Hue, L.11
Rider, M.H.12
-
50
-
-
44449103256
-
Important role of the LKB1-AMPK pathway in suppressing tumourigenesis in PTEN deficient mice
-
Huang X, Wullschleger S, Shpiro N, McGuire VA, Sakamoto K, Woods YL, McBurnie W, Fleming S, Alessi DR. Important role of the LKB1-AMPK pathway in suppressing tumourigenesis in PTEN deficient mice. Biochem J 412: 211-221, 2008.
-
(2008)
Biochem J
, vol.412
, pp. 211-221
-
-
Huang, X.1
Wullschleger, S.2
Shpiro, N.3
McGuire, V.A.4
Sakamoto, K.5
Woods, Y.L.6
McBurnie, W.7
Fleming, S.8
Alessi, D.R.9
-
51
-
-
34248357199
-
Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo
-
Hurov JB, Huang M, White LS, Lennerz J, Choi CS, Cho YR, Kim HJ, Prior JL, Piwnica-Worms D, Cantley LC, Kim JK, Shulman GI, Piwnica-Worms H. Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo. Proc Natl Acad Sci USA 104: 5680-5685, 2007.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 5680-5685
-
-
Hurov, J.B.1
Huang, M.2
White, L.S.3
Lennerz, J.4
Choi, C.S.5
Cho, Y.R.6
Kim, H.J.7
Prior, J.L.8
Piwnica-Worms, D.9
Cantley, L.C.10
Kim, J.K.11
Shulman, G.I.12
Piwnica-Worms, H.13
-
52
-
-
1942540791
-
Atypical PKC phosphorylates PAR-1 kinases to regulate localization and activity
-
Hurov JB, Watkins JL, Piwnica-Worms H. Atypical PKC phosphorylates PAR-1 kinases to regulate localization and activity. Curr Biol 14: 736-741, 2004.
-
(2004)
Curr Biol
, vol.14
, pp. 736-741
-
-
Hurov, J.B.1
Watkins, J.L.2
Piwnica-Worms, H.3
-
53
-
-
53749095429
-
-
Jang C, Lee G, Chung J. LKB1 induces apical trafficking of Silnoon, a monocarboxylate transporter, in Drosophila melanogaster. J Cell Biol 183: 11-17, 2008.
-
Jang C, Lee G, Chung J. LKB1 induces apical trafficking of Silnoon, a monocarboxylate transporter, in Drosophila melanogaster. J Cell Biol 183: 11-17, 2008.
-
-
-
-
54
-
-
29244431680
-
Mucosal prolapse in the pathogenesis of Peutz-Jeghers polyposis
-
Jansen M, de Leng WW, Baas AF, Myoshi H, Mathus-Vliegen L, Taketo MM, Clevers H, Giardiello FM, Offerhaus GJ. Mucosal prolapse in the pathogenesis of Peutz-Jeghers polyposis. Gut 55: 1-5, 2006.
-
(2006)
Gut
, vol.55
, pp. 1-5
-
-
Jansen, M.1
de Leng, W.W.2
Baas, A.F.3
Myoshi, H.4
Mathus-Vliegen, L.5
Taketo, M.M.6
Clevers, H.7
Giardiello, F.M.8
Offerhaus, G.J.9
-
55
-
-
0031974516
-
Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase
-
Jenne DE, Reimann H, Nezu J, Friedel W, Loff S, Jeschke R, Muller O, Back W, Zimmer M. Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase. Nature Genet 18: 38-43, 1998.
-
(1998)
Nature Genet
, vol.18
, pp. 38-43
-
-
Jenne, D.E.1
Reimann, H.2
Nezu, J.3
Friedel, W.4
Loff, S.5
Jeschke, R.6
Muller, O.7
Back, W.8
Zimmer, M.9
-
56
-
-
34547926839
-
LKB1 modulates lung cancer differentiation and metastasis
-
Ji H, Ramsey MR, Hayes DN, Fan C, McNamara K, Kozlowski P, Torrice C, Wu MC, Shimamura T, Perera SA, Liang MC, Cai D, Naumov GN, Bao L, Contreras CM, Li D, Chen L, Krishnamurthy J, Koivunen J, Chirieac LR, Padera RF, Bronson RT, Lindeman NI, Christiani DC, Lin X, Shapiro GI, Janne PA, Johnson BE, Meyerson M, Kwiatkowski DJ, Castrillon DH, Bardeesy N, Sharpless NE, Wong KK. LKB1 modulates lung cancer differentiation and metastasis. Nature 448: 807-810, 2007.
-
(2007)
Nature
, vol.448
, pp. 807-810
-
-
Ji, H.1
Ramsey, M.R.2
Hayes, D.N.3
Fan, C.4
McNamara, K.5
Kozlowski, P.6
Torrice, C.7
Wu, M.C.8
Shimamura, T.9
Perera, S.A.10
Liang, M.C.11
Cai, D.12
Naumov, G.N.13
Bao, L.14
Contreras, C.M.15
Li, D.16
Chen, L.17
Krishnamurthy, J.18
Koivunen, J.19
Chirieac, L.R.20
Padera, R.F.21
Bronson, R.T.22
Lindeman, N.I.23
Christiani, D.C.24
Lin, X.25
Shapiro, G.I.26
Janne, P.A.27
Johnson, B.E.28
Meyerson, M.29
Kwiatkowski, D.J.30
Castrillon, D.H.31
Bardeesy, N.32
Sharpless, N.E.33
Wong, K.K.34
more..
-
57
-
-
0037173013
-
Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposis
-
Jishage K, Nezu J, Kawase Y, Iwata T, Watanabe M, Miyoshi A, Ose A, Habu K, Kake T, Kamada N, Ueda O, Kinoshita M, Jenne DE, Shimane M, Suzuki H. Role of Lkb1, the causative gene of Peutz-Jegher's syndrome, in embryogenesis and polyposis. Proc Natl Acad Sci USA 99: 8903-8908, 2002.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 8903-8908
-
-
Jishage, K.1
Nezu, J.2
Kawase, Y.3
Iwata, T.4
Watanabe, M.5
Miyoshi, A.6
Ose, A.7
Habu, K.8
Kake, T.9
Kamada, N.10
Ueda, O.11
Kinoshita, M.12
Jenne, D.E.13
Shimane, M.14
Suzuki, H.15
-
58
-
-
0345832116
-
Knockout of the alpha2 but not alpha1 5′-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside but not contraction-induced glucose uptake in skeletal muscle
-
Jorgensen SB, Viollet B, Andreelli F, Frosig C, Birk JB, Schjerling P, Vaulont S, Richter EA, Wojtaszewski JF. Knockout of the alpha2 but not alpha1 5′-AMP-activated protein kinase isoform abolishes 5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside but not contraction-induced glucose uptake in skeletal muscle. J Biol Chem 279: 1070-1079, 2004.
-
(2004)
J Biol Chem
, vol.279
, pp. 1070-1079
-
-
Jorgensen, S.B.1
Viollet, B.2
Andreelli, F.3
Frosig, C.4
Birk, J.B.5
Schjerling, P.6
Vaulont, S.7
Richter, E.A.8
Wojtaszewski, J.F.9
-
59
-
-
41349114071
-
LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis
-
Katajisto P, Vaahtomeri K, Ekman N, Ventela E, Ristimaki A, Bardeesy N, Feil R, DePinho RA, Makela TP. LKB1 signaling in mesenchymal cells required for suppression of gastrointestinal polyposis. Nature Genet 40: 455-459, 2008.
-
(2008)
Nature Genet
, vol.40
, pp. 455-459
-
-
Katajisto, P.1
Vaahtomeri, K.2
Ekman, N.3
Ventela, E.4
Ristimaki, A.5
Bardeesy, N.6
Feil, R.7
DePinho, R.A.8
Makela, T.P.9
-
60
-
-
33845411885
-
The LKB1 tumor suppressor kinase in human disease
-
Katajisto P, Vallenius T, Vaahtomeri K, Ekman N, Udd L, Tiainen M, Makela TP. The LKB1 tumor suppressor kinase in human disease. Biochim Biophys Acta 1775: 63-75, 2007.
-
(2007)
Biochim Biophys Acta
, vol.1775
, pp. 63-75
-
-
Katajisto, P.1
Vallenius, T.2
Vaahtomeri, K.3
Ekman, N.4
Udd, L.5
Tiainen, M.6
Makela, T.P.7
-
61
-
-
0037019068
-
Molecular genetic evidence of an association between nasal polyposis and the Peutz-Jeghers syndrome
-
Keller JJ, Westerman AM, de Rooij FW, Wilson JH, van Dekken H, Giardiello FM, Weterman MA, Offerhaus GJ. Molecular genetic evidence of an association between nasal polyposis and the Peutz-Jeghers syndrome. Ann Int Med 136: 855-856, 2002.
-
(2002)
Ann Int Med
, vol.136
, pp. 855-856
-
-
Keller, J.J.1
Westerman, A.M.2
de Rooij, F.W.3
Wilson, J.H.4
van Dekken, H.5
Giardiello, F.M.6
Weterman, M.A.7
Offerhaus, G.J.8
-
62
-
-
0024284814
-
Identification of genes required for cytoplasmic localization in early C. elegans embryos
-
Kemphues KJ, Priess JR, Morton DG, Cheng NS. Identification of genes required for cytoplasmic localization in early C. elegans embryos. Cell 52: 311-320, 1988.
-
(1988)
Cell
, vol.52
, pp. 311-320
-
-
Kemphues, K.J.1
Priess, J.R.2
Morton, D.G.3
Cheng, N.S.4
-
63
-
-
1642396519
-
Enhanced stem cell survival in familial adenomatous polyposis
-
Kim KM, Calabrese P, Tavare S, Shibata D. Enhanced stem cell survival in familial adenomatous polyposis. Am J Pathol 164: 1369-1377, 2004.
-
(2004)
Am J Pathol
, vol.164
, pp. 1369-1377
-
-
Kim, K.M.1
Calabrese, P.2
Tavare, S.3
Shibata, D.4
-
64
-
-
0032524104
-
Landscaping the cancer terrain
-
Kinzler KW, Vogelstein B. Landscaping the cancer terrain. Science 280: 1036-1037, 1998.
-
(1998)
Science
, vol.280
, pp. 1036-1037
-
-
Kinzler, K.W.1
Vogelstein, B.2
-
65
-
-
13644267037
-
Mammalian SAD kinases are required for neuronal polarization
-
Kishi M, Pan YA, Crump JG, Sanes JR. Mammalian SAD kinases are required for neuronal polarization. Science 307: 929-932, 2005.
-
(2005)
Science
, vol.307
, pp. 929-932
-
-
Kishi, M.1
Pan, Y.A.2
Crump, J.G.3
Sanes, J.R.4
-
66
-
-
1642276419
-
Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout mice
-
Klezovitch O, Fernandez TE, Tapscott SJ, Vasioukhin V. Loss of cell polarity causes severe brain dysplasia in Lgl1 knockout mice. Genes Dev 18: 559-571, 2004.
-
(2004)
Genes Dev
, vol.18
, pp. 559-571
-
-
Klezovitch, O.1
Fernandez, T.E.2
Tapscott, S.J.3
Vasioukhin, V.4
-
67
-
-
39149130360
-
Mechanisms of asymmetric stem cell division
-
Knoblich JA. Mechanisms of asymmetric stem cell division. Cell 132: 583-597, 2008.
-
(2008)
Cell
, vol.132
, pp. 583-597
-
-
Knoblich, J.A.1
-
68
-
-
33751013309
-
Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3
-
Koh HJ, Arnolds DE, Fujii N, Tran TT, Rogers MJ, Jessen N, Li Y, Liew CW, Ho RC, Hirshman MF, Kulkarni RN, Kahn CR, Goodyear LJ. Skeletal muscle-selective knockout of LKB1 increases insulin sensitivity, improves glucose homeostasis, and decreases TRB3. Mol Cell Biol 26: 8217-8227, 2006.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 8217-8227
-
-
Koh, H.J.1
Arnolds, D.E.2
Fujii, N.3
Tran, T.T.4
Rogers, M.J.5
Jessen, N.6
Li, Y.7
Liew, C.W.8
Ho, R.C.9
Hirshman, M.F.10
Kulkarni, R.N.11
Kahn, C.R.12
Goodyear, L.J.13
-
69
-
-
34548179000
-
Suppression of tubulin polymerization by the LKB1-microtubule-associated protein/microtubule affinity-regulating kinase signaling
-
Kojima Y, Miyoshi H, Clevers HC, Oshima M, Aoki M, Taketo MM. Suppression of tubulin polymerization by the LKB1-microtubule-associated protein/microtubule affinity-regulating kinase signaling. J Biol Chem 282: 23532-23540, 2007.
-
(2007)
J Biol Chem
, vol.282
, pp. 23532-23540
-
-
Kojima, Y.1
Miyoshi, H.2
Clevers, H.C.3
Oshima, M.4
Aoki, M.5
Taketo, M.M.6
-
70
-
-
24644494270
-
Asymmetric cell divisions promote stratification and differentiation of mammalian skin
-
Lechler T, Fuchs E. Asymmetric cell divisions promote stratification and differentiation of mammalian skin. Nature 437: 275-280, 2005.
-
(2005)
Nature
, vol.437
, pp. 275-280
-
-
Lechler, T.1
Fuchs, E.2
-
71
-
-
31844432828
-
Lgl, Pins and aPKC regulate neuroblast self-renewal versus differentiation
-
Lee CY, Robinson KJ, Doe CQ. Lgl, Pins and aPKC regulate neuroblast self-renewal versus differentiation. Nature 439: 594-598, 2006.
-
(2006)
Nature
, vol.439
, pp. 594-598
-
-
Lee, C.Y.1
Robinson, K.J.2
Doe, C.Q.3
-
72
-
-
34250827107
-
Energy-dependent regulation of cell structure by AMP-activated protein kinase
-
Lee JH, Koh H, Kim M, Kim Y, Lee SY, Karess RE, Lee SH, Shong M, Kim JM, Kim J, Chung J. Energy-dependent regulation of cell structure by AMP-activated protein kinase. Nature 447: 1017-1020, 2007.
-
(2007)
Nature
, vol.447
, pp. 1017-1020
-
-
Lee, J.H.1
Koh, H.2
Kim, M.3
Kim, Y.4
Lee, S.Y.5
Karess, R.E.6
Lee, S.H.7
Shong, M.8
Kim, J.M.9
Kim, J.10
Chung, J.11
-
73
-
-
38849171845
-
Expansion of a mutated clone: From stem cell to tumour
-
Leedham SJ, Wright NA. Expansion of a mutated clone: from stem cell to tumour. J Clin Pathol 61: 164-171, 2008.
-
(2008)
J Clin Pathol
, vol.61
, pp. 164-171
-
-
Leedham, S.J.1
Wright, N.A.2
-
74
-
-
0042622241
-
Further observations on LKB1/STK11 status and cancer risk in Peutz-Jeghers syndrome
-
Lim W, Hearle N, Shah B, Murday V, Hodgson SV, Lucassen A, Eccles D, Talbot I, Neale K, Lim AG, O'Donohue J, Donaldson A, Macdonald RC, Young ID, Robinson MH, Lee PW, Stoodley BJ, Tomlinson I, Alderson D, Holbrook AG, Vyas S, Swarbrick ET, Lewis AA, Phillips RK, Houlston RS. Further observations on LKB1/STK11 status and cancer risk in Peutz-Jeghers syndrome. Br J Cancer 89: 308-313, 2003.
-
(2003)
Br J Cancer
, vol.89
, pp. 308-313
-
-
Lim, W.1
Hearle, N.2
Shah, B.3
Murday, V.4
Hodgson, S.V.5
Lucassen, A.6
Eccles, D.7
Talbot, I.8
Neale, K.9
Lim, A.G.10
O'Donohue, J.11
Donaldson, A.12
Macdonald, R.C.13
Young, I.D.14
Robinson, M.H.15
Lee, P.W.16
Stoodley, B.J.17
Tomlinson, I.18
Alderson, D.19
Holbrook, A.G.20
Vyas, S.21
Swarbrick, E.T.22
Lewis, A.A.23
Phillips, R.K.24
Houlston, R.S.25
more..
-
75
-
-
0019403076
-
Does Peutz-Jeghers syndrome predispose to gastrointestinal malignancy? A later look
-
Linos DA, Dozois RR, Dahlin DC, Bartholomew LG. Does Peutz-Jeghers syndrome predispose to gastrointestinal malignancy? A later look. Arch Surg 116: 1182-1184, 1981.
-
(1981)
Arch Surg
, vol.116
, pp. 1182-1184
-
-
Linos, D.A.1
Dozois, R.R.2
Dahlin, D.C.3
Bartholomew, L.G.4
-
76
-
-
12144287284
-
LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1
-
Lizcano JM, Goransson O, Toth R, Deak M, Morrice NA, Boudeau J, Hawley SA, Udd L, Makela TP, Hardie DG, Alessi DR. LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1. EMBO J 23: 833-843, 2004.
-
(2004)
EMBO J
, vol.23
, pp. 833-843
-
-
Lizcano, J.M.1
Goransson, O.2
Toth, R.3
Deak, M.4
Morrice, N.A.5
Boudeau, J.6
Hawley, S.A.7
Udd, L.8
Makela, T.P.9
Hardie, D.G.10
Alessi, D.R.11
-
77
-
-
0037032835
-
The protein kinase complement of the human genome
-
Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S. The protein kinase complement of the human genome. Science 298: 1912-1934, 2002.
-
(2002)
Science
, vol.298
, pp. 1912-1934
-
-
Manning, G.1
Whyte, D.B.2
Martinez, R.3
Hunter, T.4
Sudarsanam, S.5
-
78
-
-
0037461735
-
A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity
-
Martin SG, St Johnston D. A role for Drosophila LKB1 in anterior-posterior axis formation and epithelial polarity. Nature 421: 379-384, 2003.
-
(2003)
Nature
, vol.421
, pp. 379-384
-
-
Martin, S.G.1
St Johnston, D.2
-
79
-
-
34748845413
-
Prevalence and specificity of LKB1 genetic alterations in lung cancers
-
Matsumoto S, Iwakawa R, Takahashi K, Kohno T, Nakanishi Y, Matsuno Y, Suzuki K, Nakamoto M, Shimizu E, Minna JD, Yokota J. Prevalence and specificity of LKB1 genetic alterations in lung cancers. Oncogene 26: 5911-5918, 2007.
-
(2007)
Oncogene
, vol.26
, pp. 5911-5918
-
-
Matsumoto, S.1
Iwakawa, R.2
Takahashi, K.3
Kohno, T.4
Nakanishi, Y.5
Matsuno, Y.6
Suzuki, K.7
Nakamoto, M.8
Shimizu, E.9
Minna, J.D.10
Yokota, J.11
-
80
-
-
33749070180
-
Peutz-Jeghers syndrome: Clinicopathology and molecular alterations
-
McGarrity TJ, Amos C. Peutz-Jeghers syndrome: clinicopathology and molecular alterations. Cell Mol Life Sci 63: 2135-2144, 2006.
-
(2006)
Cell Mol Life Sci
, vol.63
, pp. 2135-2144
-
-
McGarrity, T.J.1
Amos, C.2
-
81
-
-
40949146900
-
Normal hypertrophy accompanied by phosphoryation and activation of AMP-activated protein kinase alpha1 following overload in LKB1 knockout mice
-
McGee SL, Mustard KJ, Hardie DG, Baar K. Normal hypertrophy accompanied by phosphoryation and activation of AMP-activated protein kinase alpha1 following overload in LKB1 knockout mice. J Physiol 586: 1731-1741, 2008.
-
(2008)
J Physiol
, vol.586
, pp. 1731-1741
-
-
McGee, S.L.1
Mustard, K.J.2
Hardie, D.G.3
Baar, K.4
-
82
-
-
0742270597
-
Crystal structure of MO25 alpha in complex with the C terminus of the pseudo kinase STE20-related adaptor
-
Milburn CC, Boudeau J, Deak M, Alessi DR, van Aalten DM. Crystal structure of MO25 alpha in complex with the C terminus of the pseudo kinase STE20-related adaptor. Nature Struct Mol Biol 11: 193-200, 2004.
-
(2004)
Nature Struct Mol Biol
, vol.11
, pp. 193-200
-
-
Milburn, C.C.1
Boudeau, J.2
Deak, M.3
Alessi, D.R.4
van Aalten, D.M.5
-
83
-
-
0021079787
-
Adenocarcinoma of the rectum arising in a hamartomatous polyp in a patient with Peutz-Jeghers syndrome
-
Miller LJ, Bartholomew LG, Dozois RR, Dahlin DC. Adenocarcinoma of the rectum arising in a hamartomatous polyp in a patient with Peutz-Jeghers syndrome. Dig Dis Sci 28: 1047-1051, 1983.
-
(1983)
Dig Dis Sci
, vol.28
, pp. 1047-1051
-
-
Miller, L.J.1
Bartholomew, L.G.2
Dozois, R.R.3
Dahlin, D.C.4
-
84
-
-
34248185949
-
LKB1 and AMPK maintain epithelial cell polarity under energetic stress
-
Mirouse V, Swick LL, Kazgan N, St Johnston D, Brenman JE. LKB1 and AMPK maintain epithelial cell polarity under energetic stress. J Cell Biol 177: 387-392, 2007.
-
(2007)
J Cell Biol
, vol.177
, pp. 387-392
-
-
Mirouse, V.1
Swick, L.L.2
Kazgan, N.3
St Johnston, D.4
Brenman, J.E.5
-
85
-
-
0037089467
-
Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice
-
Miyoshi H, Nakau M, Ishikawa TO, Seldin MF, Oshima M, Taketo MM. Gastrointestinal hamartomatous polyposis in Lkb1 heterozygous knockout mice. Cancer Res 62: 2261-2266, 2002.
-
(2002)
Cancer Res
, vol.62
, pp. 2261-2266
-
-
Miyoshi, H.1
Nakau, M.2
Ishikawa, T.O.3
Seldin, M.F.4
Oshima, M.5
Taketo, M.M.6
-
86
-
-
0026773728
-
par-4, a gene required for cytoplasmic localization and determination of specific cell types in Caenorhabditis elegans embryogenesis
-
Morton DG, Roos JM, Kemphues KJ. par-4, a gene required for cytoplasmic localization and determination of specific cell types in Caenorhabditis elegans embryogenesis. Genetics 130: 771-790, 1992.
-
(1992)
Genetics
, vol.130
, pp. 771-790
-
-
Morton, D.G.1
Roos, J.M.2
Kemphues, K.J.3
-
87
-
-
0037102428
-
Hepatocellular carcinoma caused by loss of heterozygosity in Lkb1 gene knockout mice
-
Nakau M, Miyoshi H, Seldin MF, Imamura M, Oshima M, Taketo MM. Hepatocellular carcinoma caused by loss of heterozygosity in Lkb1 gene knockout mice. Cancer Res 62: 4549-4553, 2002.
-
(2002)
Cancer Res
, vol.62
, pp. 4549-4553
-
-
Nakau, M.1
Miyoshi, H.2
Seldin, M.F.3
Imamura, M.4
Oshima, M.5
Taketo, M.M.6
-
88
-
-
48449094498
-
AMPK and PPARdelta agonists are exercise mimetics
-
Narkar VA, Downes M, Yu RT, Embler E, Wang YX, Banayo E, Mihaylova MM, Nelson MC, Zou Y, Juguilon H, Kang H, Shaw RJ, Evans RM. AMPK and PPARdelta agonists are exercise mimetics. Cell 134: 405-415, 2008.
-
(2008)
Cell
, vol.134
, pp. 405-415
-
-
Narkar, V.A.1
Downes, M.2
Yu, R.T.3
Embler, E.4
Wang, Y.X.5
Banayo, E.6
Mihaylova, M.M.7
Nelson, M.C.8
Zou, Y.9
Juguilon, H.10
Kang, H.11
Shaw, R.J.12
Evans, R.M.13
-
89
-
-
23844445836
-
Colorectal cancer: Mutations in a signalling pathway
-
Parsons DW, Wang TL, Samuels Y, Bardelli A, Cummins JM, DeLong L, Silliman N, Ptak J, Szabo S, Willson JK, Markowitz S, Kinzler KW, Vogelstein B, Lengauer C, Velculescu VE. Colorectal cancer: mutations in a signalling pathway. Nature 436: 792, 2005.
-
(2005)
Nature
, vol.436
, pp. 792
-
-
Parsons, D.W.1
Wang, T.L.2
Samuels, Y.3
Bardelli, A.4
Cummins, J.M.5
DeLong, L.6
Silliman, N.7
Ptak, J.8
Szabo, S.9
Willson, J.K.10
Markowitz, S.11
Kinzler, K.W.12
Vogelstein, B.13
Lengauer, C.14
Velculescu, V.E.15
-
90
-
-
42049113832
-
Lkb1 deficiency causes prostate neoplasia in the mouse
-
Pearson HB, McCarthy A, Collins CM, Ashworth A, Clarke AR. Lkb1 deficiency causes prostate neoplasia in the mouse. Cancer Res 68: 2223-2232, 2008.
-
(2008)
Cancer Res
, vol.68
, pp. 2223-2232
-
-
Pearson, H.B.1
McCarthy, A.2
Collins, C.M.3
Ashworth, A.4
Clarke, A.R.5
-
91
-
-
34447637612
-
Polyhydramnios, megalencephaly and symptomatic epilepsy caused by a homozygous 7-kilobase deletion in LYK5
-
Puffenberger EG, Strauss KA, Ramsey KE, Craig DW, Stephan DA, Robinson DL, Hendrickson CL, Gottlieb S, Ramsay DA, Siu VM, Heuer GG, Crino PB, Morton DH. Polyhydramnios, megalencephaly and symptomatic epilepsy caused by a homozygous 7-kilobase deletion in LYK5. Brain 130: 1929-1941, 2007.
-
(2007)
Brain
, vol.130
, pp. 1929-1941
-
-
Puffenberger, E.G.1
Strauss, K.A.2
Ramsey, K.E.3
Craig, D.W.4
Stephan, D.A.5
Robinson, D.L.6
Hendrickson, C.L.7
Gottlieb, S.8
Ramsay, D.A.9
Siu, V.M.10
Heuer, G.G.11
Crino, P.B.12
Morton, D.H.13
-
92
-
-
0037125996
-
Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis
-
Rossi DJ, Ylikorkala A, Korsisaari N, Salovaara R, Luukko K, Launonen V, Henkemeyer M, Ristimaki A, Aaltonen LA, Makela TP. Induction of cyclooxygenase-2 in a mouse model of Peutz-Jeghers polyposis. Proc Natl Acad Sci USA 99: 12327-12332, 2002.
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 12327-12332
-
-
Rossi, D.J.1
Ylikorkala, A.2
Korsisaari, N.3
Salovaara, R.4
Luukko, K.5
Launonen, V.6
Henkemeyer, M.7
Ristimaki, A.8
Aaltonen, L.A.9
Makela, T.P.10
-
93
-
-
35348992639
-
The genetics of hereditary colon cancer
-
Rustgi AK. The genetics of hereditary colon cancer. Genes Dev 21: 2525-2538, 2007.
-
(2007)
Genes Dev
, vol.21
, pp. 2525-2538
-
-
Rustgi, A.K.1
-
94
-
-
17144474893
-
Activity of LKB1 and AMPK-related kinases in skeletal muscle: Effects of contraction, phenformin, and AICAR
-
Sakamoto K, Goransson O, Hardie DG, Alessi DR. Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR. Am J Physiol Endocrinol Metab 287: E310-E317, 2004.
-
(2004)
Am J Physiol Endocrinol Metab
, vol.287
-
-
Sakamoto, K.1
Goransson, O.2
Hardie, D.G.3
Alessi, D.R.4
-
95
-
-
20044370885
-
Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction
-
Sakamoto K, McCarthy A, Smith D, Green KA, Grahame Hardie D, Ashworth A, Alessi DR. Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction. EMBO J 24: 1810-1820, 2005.
-
(2005)
EMBO J
, vol.24
, pp. 1810-1820
-
-
Sakamoto, K.1
McCarthy, A.2
Smith, D.3
Green, K.A.4
Grahame Hardie, D.5
Ashworth, A.6
Alessi, D.R.7
-
97
-
-
0036645286
-
Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung
-
Sanchez-Cespedes M, Parrella P, Esteller M, Nomoto S, Trink B, Engles JM, Westra WH, Herman JG, Sidransky D. Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung. Cancer Res 62: 3659-3662, 2002.
-
(2002)
Cancer Res
, vol.62
, pp. 3659-3662
-
-
Sanchez-Cespedes, M.1
Parrella, P.2
Esteller, M.3
Nomoto, S.4
Trink, B.5
Engles, J.M.6
Westra, W.H.7
Herman, J.G.8
Sidransky, D.9
-
98
-
-
34147152841
-
Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade
-
Sanders MJ, Grondin PO, Hegarty BD, Snowden MA, Carling D. Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade. Biochem J 403: 139-148, 2007.
-
(2007)
Biochem J
, vol.403
, pp. 139-148
-
-
Sanders, M.J.1
Grondin, P.O.2
Hegarty, B.D.3
Snowden, M.A.4
Carling, D.5
-
99
-
-
0036901639
-
Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366
-
Sapkota GP, Deak M, Kieloch A, Morrice N, Goodarzi AA, Smythe C, Shiloh Y, Lees-Miller SP, Alessi DR. Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366. Biochem J 368: 507-516, 2002.
-
(2002)
Biochem J
, vol.368
, pp. 507-516
-
-
Sapkota, G.P.1
Deak, M.2
Kieloch, A.3
Morrice, N.4
Goodarzi, A.A.5
Smythe, C.6
Shiloh, Y.7
Lees-Miller, S.P.8
Alessi, D.R.9
-
100
-
-
0035375261
-
Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell growth
-
Sapkota GP, Kieloch A, Lizcano JM, Lain S, Arthur JS, Williams MR, Morrice N, Deak M, Alessi DR. Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell growth. J Biol Chem 276: 19469 -19482, 2001.
-
(2001)
J Biol Chem
, vol.276
, pp. 19469-19482
-
-
Sapkota, G.P.1
Kieloch, A.2
Lizcano, J.M.3
Lain, S.4
Arthur, J.S.5
Williams, M.R.6
Morrice, N.7
Deak, M.8
Alessi, D.R.9
-
101
-
-
0035184065
-
STK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary-mucinous neoplasms of the pancreas
-
Sato N, Rosty C, Jansen M, Fukushima N, Ueki T, Yeo CJ, Cameron JL, Iacobuzio-Donahue CA, Hruban RH, Goggins M. STK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary-mucinous neoplasms of the pancreas. Am J Pathol 159: 2017-2022, 2001.
-
(2001)
Am J Pathol
, vol.159
, pp. 2017-2022
-
-
Sato, N.1
Rosty, C.2
Jansen, M.3
Fukushima, N.4
Ueki, T.5
Yeo, C.J.6
Cameron, J.L.7
Iacobuzio-Donahue, C.A.8
Hruban, R.H.9
Goggins, M.10
-
102
-
-
45549086246
-
LKB1 and lung cancer: More than the usual suspects
-
Shah U, Sharpless NE, Hayes DN. LKB1 and lung cancer: more than the usual suspects. Cancer Res 68: 3562-3565, 2008.
-
(2008)
Cancer Res
, vol.68
, pp. 3562-3565
-
-
Shah, U.1
Sharpless, N.E.2
Hayes, D.N.3
-
103
-
-
3142594193
-
The LKB1 tumor suppressor negatively regulates mTOR signaling
-
Shaw RJ, Bardeesy N, Manning BD, Lopez L, Kosmatka M, DePinho RA, Cantley LC. The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell 6: 91-99, 2004.
-
(2004)
Cancer Cell
, vol.6
, pp. 91-99
-
-
Shaw, R.J.1
Bardeesy, N.2
Manning, B.D.3
Lopez, L.4
Kosmatka, M.5
DePinho, R.A.6
Cantley, L.C.7
-
104
-
-
1542618348
-
The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
-
Shaw RJ, Kosmatka M, Bardeesy N, Hurley RL, Witters LA, DePinho RA, Cantley LC. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc Natl Acad Sci USA 101: 3329-3335, 2004.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 3329-3335
-
-
Shaw, R.J.1
Kosmatka, M.2
Bardeesy, N.3
Hurley, R.L.4
Witters, L.A.5
DePinho, R.A.6
Cantley, L.C.7
-
105
-
-
28844433635
-
The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin
-
Shaw RJ, Lamia KA, Vasquez D, Koo SH, Bardeesy N, Depinho RA, Montminy M, Cantley LC. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 310: 1642-1646, 2005.
-
(2005)
Science
, vol.310
, pp. 1642-1646
-
-
Shaw, R.J.1
Lamia, K.A.2
Vasquez, D.3
Koo, S.H.4
Bardeesy, N.5
Depinho, R.A.6
Montminy, M.7
Cantley, L.C.8
-
106
-
-
0023270123
-
Epithelial misplacement in Peutz-Jeghers polyps. A diagnostic pitfall
-
Shepherd NA, Bussey HJ, Jass JR. Epithelial misplacement in Peutz-Jeghers polyps. A diagnostic pitfall. Am J Surg Pathol 11: 743-749, 1987.
-
(1987)
Am J Surg Pathol
, vol.11
, pp. 743-749
-
-
Shepherd, N.A.1
Bussey, H.J.2
Jass, J.R.3
-
108
-
-
0032815880
-
The mouse Peutz-Jeghers syndrome gene Lkb1 encodes a nuclear protein kinase
-
Smith DP, Spicer J, Smith A, Swift S, Ashworth A. The mouse Peutz-Jeghers syndrome gene Lkb1 encodes a nuclear protein kinase. Hum Mol Genet 8: 1479-1485, 1999.
-
(1999)
Hum Mol Genet
, vol.8
, pp. 1479-1485
-
-
Smith, D.P.1
Spicer, J.2
Smith, A.3
Swift, S.4
Ashworth, A.5
-
109
-
-
45549094869
-
Protein kinase C zeta-dependent LKB1 serine 428 phosphorylation increases LKB1 nucleus export and apoptosis in endothelial cells
-
Song P, Xie Z, Wu Y, Xu J, Dong Y, Zou MH. Protein kinase C zeta-dependent LKB1 serine 428 phosphorylation increases LKB1 nucleus export and apoptosis in endothelial cells. J Biol Chem 283: 12446-12455, 2008.
-
(2008)
J Biol Chem
, vol.283
, pp. 12446-12455
-
-
Song, P.1
Xie, Z.2
Wu, Y.3
Xu, J.4
Dong, Y.5
Zou, M.H.6
-
110
-
-
0042090214
-
Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1
-
Spicer J, Rayter S, Young N, Elliott R, Ashworth A, Smith D. Regulation of the Wnt signalling component PAR1A by the Peutz-Jeghers syndrome kinase LKB1. Oncogene 22: 4752- 4756, 2003.
-
(2003)
Oncogene
, vol.22
, pp. 4752-4756
-
-
Spicer, J.1
Rayter, S.2
Young, N.3
Elliott, R.4
Ashworth, A.5
Smith, D.6
-
111
-
-
13344285343
-
Mammalian AMP-activated protein kinase subfamily
-
Stapleton D, Mitchelhill KI, Gao G, Widmer J, Michell BJ, Teh T, House CM, Fernandez CS, Cox T, Witters LA, Kemp BE. Mammalian AMP-activated protein kinase subfamily. J Biol Chem 271: 611-614, 1996.
-
(1996)
J Biol Chem
, vol.271
, pp. 611-614
-
-
Stapleton, D.1
Mitchelhill, K.I.2
Gao, G.3
Widmer, J.4
Michell, B.J.5
Teh, T.6
House, C.M.7
Fernandez, C.S.8
Cox, T.9
Witters, L.A.10
Kemp, B.E.11
-
112
-
-
33845949733
-
Dissecting the role of 5′-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase
-
Suter M, Riek U, Tuerk R, Schlattner U, Wallimann T, Neumann D. Dissecting the role of 5′-AMP for allosteric stimulation, activation, and deactivation of AMP-activated protein kinase. J Biol Chem 281: 32207-32216, 2006.
-
(2006)
J Biol Chem
, vol.281
, pp. 32207-32216
-
-
Suter, M.1
Riek, U.2
Tuerk, R.3
Schlattner, U.4
Wallimann, T.5
Neumann, D.6
-
113
-
-
4344699150
-
aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity
-
Suzuki A, Hirata M, Kamimura K, Maniwa R, Yamanaka T, Mizuno K, Kishikawa M, Hirose H, Amano Y, Izumi N, Miwa Y, Ohno S. aPKC acts upstream of PAR-1b in both the establishment and maintenance of mammalian epithelial polarity. Curr Biol 14: 1425-1435, 2004.
-
(2004)
Curr Biol
, vol.14
, pp. 1425-1435
-
-
Suzuki, A.1
Hirata, M.2
Kamimura, K.3
Maniwa, R.4
Yamanaka, T.5
Mizuno, K.6
Kishikawa, M.7
Hirose, H.8
Amano, Y.9
Izumi, N.10
Miwa, Y.11
Ohno, S.12
-
114
-
-
34250182374
-
Leptin stimulates fatty acid oxidation and peroxisome proliferator-activated receptor alpha gene expression in mouse C2C12 myoblasts by changing the subcellular localization of the alpha2 form of AMP-activated protein kinase
-
Suzuki A, Okamoto S, Lee S, Saito K, Shiuchi T, Minokoshi Y. Leptin stimulates fatty acid oxidation and peroxisome proliferator-activated receptor alpha gene expression in mouse C2C12 myoblasts by changing the subcellular localization of the alpha2 form of AMP-activated protein kinase. Mol Cell Biol 27: 4317-4327, 2007.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 4317-4327
-
-
Suzuki, A.1
Okamoto, S.2
Lee, S.3
Saito, K.4
Shiuchi, T.5
Minokoshi, Y.6
-
115
-
-
20144387628
-
Mimicry of a cellular low energy status blocks tumor cell anabolism and suppresses the malignant phenotype
-
Swinnen JV, Beckers A, Brusselmans K, Organe S, Segers J, Timmermans L, Vanderhoydonc F, Deboel L, Derua R, Waelkens E, De Schrijver E, Van de Sande T, Noel A, Foufelle F, Verhoeven G. Mimicry of a cellular low energy status blocks tumor cell anabolism and suppresses the malignant phenotype. Cancer Res 65: 2441-2448, 2005.
-
(2005)
Cancer Res
, vol.65
, pp. 2441-2448
-
-
Swinnen, J.V.1
Beckers, A.2
Brusselmans, K.3
Organe, S.4
Segers, J.5
Timmermans, L.6
Vanderhoydonc, F.7
Deboel, L.8
Derua, R.9
Waelkens, E.10
De Schrijver, E.11
Van de Sande, T.12
Noel, A.13
Foufelle, F.14
Verhoeven, G.15
-
116
-
-
33645022897
-
Accelerated onsets of gastric hamartomas and hepatic adenomas/carcinomas in Lkb1+/-p53-/- compound mutant mice
-
Takeda H, Miyoshi H, Kojima Y, Oshima M, Taketo MM. Accelerated onsets of gastric hamartomas and hepatic adenomas/carcinomas in Lkb1+/-p53-/- compound mutant mice. Oncogene 25: 1816-1820, 2006.
-
(2006)
Oncogene
, vol.25
, pp. 1816-1820
-
-
Takeda, H.1
Miyoshi, H.2
Kojima, Y.3
Oshima, M.4
Taketo, M.M.5
-
117
-
-
37149022967
-
LKB1 and the regulation of malonyl-CoA and fatty acid oxidation in muscle
-
Thomson DM, Brown JD, Fillmore N, Condon BM, Kim HJ, Barrow JR, Winder WW. LKB1 and the regulation of malonyl-CoA and fatty acid oxidation in muscle. Am J Physiol Endocrinol Metab 293: E1572-E1579, 2007.
-
(2007)
Am J Physiol Endocrinol Metab
, vol.293
-
-
Thomson, D.M.1
Brown, J.D.2
Fillmore, N.3
Condon, B.M.4
Kim, H.J.5
Barrow, J.R.6
Winder, W.W.7
-
118
-
-
41649083427
-
Lgl and its phosphorylation by aPKC regulate oocyte polarity formation in Drosophila
-
Tian AG, Deng WM. Lgl and its phosphorylation by aPKC regulate oocyte polarity formation in Drosophila. Development 135: 463-471, 2008.
-
(2008)
Development
, vol.135
, pp. 463-471
-
-
Tian, A.G.1
Deng, W.M.2
-
119
-
-
0141530895
-
-
Timm T, Li XY, Biernat J, Jiao J, Mandelkow E, Vandekerckhove J, Mandelkow EM. MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1. EMBO J 22: 5090-5101, 2003.
-
Timm T, Li XY, Biernat J, Jiao J, Mandelkow E, Vandekerckhove J, Mandelkow EM. MARKK, a Ste20-like kinase, activates the polarity-inducing kinase MARK/PAR-1. EMBO J 22: 5090-5101, 2003.
-
-
-
-
120
-
-
56049117647
-
A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis
-
Towler MC, Fogarty S, Hawley SA, Pan DA, Martin DM, Morrice NA, McCarthy A, Galardo MN, Meroni SB, Cigorraga SB, Ashworth A, Sakamoto K, Hardie DG. A novel short splice variant of the tumour suppressor LKB1 is required for spermiogenesis. Biochem J 416: 1-14, 2008.
-
(2008)
Biochem J
, vol.416
, pp. 1-14
-
-
Towler, M.C.1
Fogarty, S.2
Hawley, S.A.3
Pan, D.A.4
Martin, D.M.5
Morrice, N.A.6
McCarthy, A.7
Galardo, M.N.8
Meroni, S.B.9
Cigorraga, S.B.10
Ashworth, A.11
Sakamoto, K.12
Hardie, D.G.13
-
121
-
-
33847080728
-
AMP-activated protein kinase in metabolic control and insulin signaling
-
Towler MC, Hardie DG. AMP-activated protein kinase in metabolic control and insulin signaling. Circ Res 100: 328-341, 2007.
-
(2007)
Circ Res
, vol.100
, pp. 328-341
-
-
Towler, M.C.1
Hardie, D.G.2
-
122
-
-
0033915012
-
5′-CpG island methylation of the LKB1/STK11 promoter and allelic loss at chromosome 19p13.3 in sporadic colorectal cancer
-
Trojan J, Brieger A, Raedle J, Esteller M, Zeuzem S. 5′-CpG island methylation of the LKB1/STK11 promoter and allelic loss at chromosome 19p13.3 in sporadic colorectal cancer. Gut 47: 272-276, 2000.
-
(2000)
Gut
, vol.47
, pp. 272-276
-
-
Trojan, J.1
Brieger, A.2
Raedle, J.3
Esteller, M.4
Zeuzem, S.5
-
123
-
-
5144232989
-
Suppression of Peutz-Jeghers polyposis by inhibition of cyclooxygenase-2
-
Udd L, Katajisto P, Rossi DJ, Lepisto A, Lahesmaa AM, Ylikorkala A, Jarvinen HJ, Ristimaki AP, Makela TP. Suppression of Peutz-Jeghers polyposis by inhibition of cyclooxygenase-2. Gastroenterology 127: 1030-1037, 2004.
-
(2004)
Gastroenterology
, vol.127
, pp. 1030-1037
-
-
Udd, L.1
Katajisto, P.2
Rossi, D.J.3
Lepisto, A.4
Lahesmaa, A.M.5
Ylikorkala, A.6
Jarvinen, H.J.7
Ristimaki, A.P.8
Makela, T.P.9
-
124
-
-
59149102643
-
Lkb1 is required for TGFβ-mediated myofibroblast differentiation
-
Vaahtomeri K, Ventela E, Laajanen K, Katajisto P, Wipff PJ, Hinz B, Vallenius T, Tiainen M, Makela TP. Lkb1 is required for TGFβ-mediated myofibroblast differentiation. J Cell Sci 121: 3531-3540, 2008.
-
(2008)
J Cell Sci
, vol.121
, pp. 3531-3540
-
-
Vaahtomeri, K.1
Ventela, E.2
Laajanen, K.3
Katajisto, P.4
Wipff, P.J.5
Hinz, B.6
Vallenius, T.7
Tiainen, M.8
Makela, T.P.9
-
125
-
-
0037251455
-
The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity
-
Viollet B, Andreelli F, Jorgensen SB, Perrin C, Geloen A, Flamez D, Mu J, Lenzner C, Baud O, Bennoun M, Gomas E, Nicolas G, Wojtaszewski JF, Kahn A, Carling D, Schuit FC, Birnbaum MJ, Richter EA, Burcelin R, Vaulont S. The AMP-activated protein kinase alpha2 catalytic subunit controls whole-body insulin sensitivity. J Clin Invest 111: 91-98, 2003.
-
(2003)
J Clin Invest
, vol.111
, pp. 91-98
-
-
Viollet, B.1
Andreelli, F.2
Jorgensen, S.B.3
Perrin, C.4
Geloen, A.5
Flamez, D.6
Mu, J.7
Lenzner, C.8
Baud, O.9
Bennoun, M.10
Gomas, E.11
Nicolas, G.12
Wojtaszewski, J.F.13
Kahn, A.14
Carling, D.15
Schuit, F.C.16
Birnbaum, M.J.17
Richter, E.A.18
Burcelin, R.19
Vaulont, S.20
more..
-
126
-
-
0034090975
-
The C. elegans par-4 gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetry
-
Watts JL, Morton DG, Bestman J, Kemphues KJ. The C. elegans par-4 gene encodes a putative serine-threonine kinase required for establishing embryonic asymmetry. Development 127: 1467-1475, 2000.
-
(2000)
Development
, vol.127
, pp. 1467-1475
-
-
Watts, J.L.1
Morton, D.G.2
Bestman, J.3
Kemphues, K.J.4
-
127
-
-
29244474612
-
Mutation of Lkb1 and p53 genes exert a cooperative effect on tumorigenesis
-
Wei C, Amos CI, Stephens LC, Campos I, Deng JM, Behringer RR, Rashid A, Frazier ML. Mutation of Lkb1 and p53 genes exert a cooperative effect on tumorigenesis. Cancer Res 65: 11297-11303, 2005.
-
(2005)
Cancer Res
, vol.65
, pp. 11297-11303
-
-
Wei, C.1
Amos, C.I.2
Stephens, L.C.3
Campos, I.4
Deng, J.M.5
Behringer, R.R.6
Rashid, A.7
Frazier, M.L.8
-
128
-
-
39749102904
-
Suppression of Peutz-Jeghers polyposis by targeting mammalian target of rapamycin signaling
-
Wei C, Amos CI, Zhang N, Wang X, Rashid A, Walker CL, Behringer RR, Frazier ML. Suppression of Peutz-Jeghers polyposis by targeting mammalian target of rapamycin signaling. Clin Cancer Res 14: 1167-1171, 2008.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 1167-1171
-
-
Wei, C.1
Amos, C.I.2
Zhang, N.3
Wang, X.4
Rashid, A.5
Walker, C.L.6
Behringer, R.R.7
Frazier, M.L.8
-
129
-
-
0033541557
-
Peutz-Jeghers syndrome: 78-year follow-up of the original family
-
Westerman AM, Entius MM, de Baar E, Boor PP, Koole R, van Velthuysen ML, Offerhaus GJ, Lindhout D, de Rooij FW, Wilson JH. Peutz-Jeghers syndrome: 78-year follow-up of the original family. Lancet 353: 1211-1215, 1999.
-
(1999)
Lancet
, vol.353
, pp. 1211-1215
-
-
Westerman, A.M.1
Entius, M.M.2
de Baar, E.3
Boor, P.P.4
Koole, R.5
van Velthuysen, M.L.6
Offerhaus, G.J.7
Lindhout, D.8
de Rooij, F.W.9
Wilson, J.H.10
-
130
-
-
34247475176
-
BDNF instructs the kinase LKB1 to grow an axon
-
Winckler B. BDNF instructs the kinase LKB1 to grow an axon. Cell 129: 459-460, 2007.
-
(2007)
Cell
, vol.129
, pp. 459-460
-
-
Winckler, B.1
-
131
-
-
59449084942
-
Psychosocial impact of Peutz-Jeghers Syndrome
-
Woo A, Sadana A, Mauger DT, Baker MJ, Berk T, McGarrity TJ. Psychosocial impact of Peutz-Jeghers Syndrome. Fam Cancer 8: 59-65, 2009.
-
(2009)
Fam Cancer
, vol.8
, pp. 59-65
-
-
Woo, A.1
Sadana, A.2
Mauger, D.T.3
Baker, M.J.4
Berk, T.5
McGarrity, T.J.6
-
132
-
-
10744230065
-
LKB1 is the upstream kinase in the AMP-activated protein kinase cascade
-
Woods A, Johnstone SR, Dickerson K, Leiper FC, Fryer LG, Neumann D, Schlattner U, Wallimann T, Carlson M, Carling D. LKB1 is the upstream kinase in the AMP-activated protein kinase cascade. Curr Biol 13: 2004-2008, 2003.
-
(2003)
Curr Biol
, vol.13
, pp. 2004-2008
-
-
Woods, A.1
Johnstone, S.R.2
Dickerson, K.3
Leiper, F.C.4
Fryer, L.G.5
Neumann, D.6
Schlattner, U.7
Wallimann, T.8
Carlson, M.9
Carling, D.10
-
133
-
-
37549065556
-
The GC kinase Fray and Mo25 regulate Drosophila asymmetric divisions
-
Yamamoto Y, Izumi Y, Matsuzaki F. The GC kinase Fray and Mo25 regulate Drosophila asymmetric divisions. Biochem Biophys Res Commun 366: 212-218, 2008.
-
(2008)
Biochem Biophys Res Commun
, vol.366
, pp. 212-218
-
-
Yamamoto, Y.1
Izumi, Y.2
Matsuzaki, F.3
-
134
-
-
0035903028
-
Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice
-
Ylikorkala A, Rossi DJ, Korsisaari N, Luukko K, Alitalo K, Henkemeyer M, Makela TP. Vascular abnormalities and deregulation of VEGF in Lkb1-deficient mice. Science 293: 1323-1326, 2001.
-
(2001)
Science
, vol.293
, pp. 1323-1326
-
-
Ylikorkala, A.1
Rossi, D.J.2
Korsisaari, N.3
Luukko, K.4
Alitalo, K.5
Henkemeyer, M.6
Makela, T.P.7
-
135
-
-
13244258315
-
Sex cord-stromal tumors of the ovary and testis: Their similarities and differences with consideration of selected problems
-
Young RH. Sex cord-stromal tumors of the ovary and testis: their similarities and differences with consideration of selected problems. Mod Pathol 18 Suppl 2: S81-98, 2005.
-
(2005)
Mod Pathol
, vol.18
, Issue.SUPPL. 2
-
-
Young, R.H.1
-
136
-
-
33751204464
-
AMP-activated protein kinase regulates the assembly of epithelial tight junctions
-
Zhang L, Li J, Young LH, Caplan MJ. AMP-activated protein kinase regulates the assembly of epithelial tight junctions. Proc Natl Acad Sci USA 103: 17272-17277, 2006.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 17272-17277
-
-
Zhang, L.1
Li, J.2
Young, L.H.3
Caplan, M.J.4
-
137
-
-
38849204971
-
The tumor suppressor LKB1 regulates lung cancer cell polarity by mediating cdc42 recruitment and activity
-
Zhang S, Schafer-Hales K, Khuri FR, Zhou W, Vertino PM, Marcus AI. The tumor suppressor LKB1 regulates lung cancer cell polarity by mediating cdc42 recruitment and activity. Cancer Res 68: 740-748, 2008.
-
(2008)
Cancer Res
, vol.68
, pp. 740-748
-
-
Zhang, S.1
Schafer-Hales, K.2
Khuri, F.R.3
Zhou, W.4
Vertino, P.M.5
Marcus, A.I.6
-
138
-
-
33846521353
-
Regulation of epithelial tight junction assembly and disassembly by AMP-activated protein kinase
-
Zheng B, Cantley LC. Regulation of epithelial tight junction assembly and disassembly by AMP-activated protein kinase. Proc Natl Acad Sci USA 104: 819-822, 2007.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 819-822
-
-
Zheng, B.1
Cantley, L.C.2
-
139
-
-
0034773404
-
Role of AMP-activated protein kinase in mechanism of metformin action
-
Zhou G, Myers R, Li Y, Chen Y, Shen X, Fenyk-Melody J, Wu M, Ventre J, Doebber T, Fujii N, Musi N, Hirshman MF, Goodyear LJ, Moller DE. Role of AMP-activated protein kinase in mechanism of metformin action. J Clin Invest 108: 1167-1174, 2001.
-
(2001)
J Clin Invest
, vol.108
, pp. 1167-1174
-
-
Zhou, G.1
Myers, R.2
Li, Y.3
Chen, Y.4
Shen, X.5
Fenyk-Melody, J.6
Wu, M.7
Ventre, J.8
Doebber, T.9
Fujii, N.10
Musi, N.11
Hirshman, M.F.12
Goodyear, L.J.13
Moller, D.E.14
|