메뉴 건너뛰기




Volumn 9, Issue 12, 2010, Pages 2363-2374

Transcriptional crosstalk between TGFβ and stem cell pathways in tumor cell invasion: Role of EMT promoting Smad complexes

Author keywords

Cancer stem cells; Crosstalk; Epithelial mesenchymal transition; Metastasis; Ras; Smad; Snail; TGF ; Transcriptional complexes; Tumor cell invasion; Wnt

Indexed keywords

BETA CATENIN; IMMEDIATE EARLY PROTEIN BZLF1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LYMPHOID ENHANCER FACTOR 1; NOTCH RECEPTOR; RAS PROTEIN; SMAD PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR FOXC2; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR SP1; TRANSCRIPTION FACTOR TWIST; TRANSFORMING GROWTH FACTOR BETA; WNT PROTEIN;

EID: 77954167982     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.9.12.12050     Document Type: Review
Times cited : (285)

References (181)
  • 1
    • 33745297408 scopus 로고    scopus 로고
    • New signals from the invasive front
    • Christofori G. New signals from the invasive front. Nature 2006; 441:444-50.
    • (2006) Nature , vol.441 , pp. 444-450
    • Christofori, G.1
  • 2
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest 2009; 119:1420-8.
    • (2009) J Clin Invest , vol.119 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 3
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mesenchymal transitions in development and disease. Cell 2009; 139:871-90.
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 4
    • 22244492306 scopus 로고    scopus 로고
    • Carcinoma invasion and metastasis: A role for epithelial-mesenchymal transition?
    • Thompson EW, Newgreen DF, Tarin D. Carcinoma invasion and metastasis: a role for epithelial-mesenchymal transition? Cancer Res 2005; 65:5991-5.
    • (2005) Cancer Res , vol.65 , pp. 5991-5995
    • Thompson, E.W.1    Newgreen, D.F.2    Tarin, D.3
  • 5
    • 33244463813 scopus 로고    scopus 로고
    • Complex networks orchestrate epithelial-mesenchymal transitions
    • Thiery JP, Sleeman JP. Complex networks orchestrate epithelial- mesenchymal transitions. Nat Rev Mol Cell Biol 2006; 7:131-42.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 131-142
    • Thiery, J.P.1    Sleeman, J.P.2
  • 7
    • 51449085561 scopus 로고    scopus 로고
    • Generation of breast cancer stem cells through epithelial-mesenchymal transition
    • Morel AP, Lievre M, Thomas C, Hinkal G, Ansieau S, Puisieux A. Generation of breast cancer stem cells through epithelial-mesenchymal transition. PLoS One 2008; 3:2888.
    • (2008) PLoS One , vol.3 , pp. 2888
    • Morel, A.P.1    Lievre, M.2    Thomas, C.3    Hinkal, G.4    Ansieau, S.5    Puisieux, A.6
  • 9
    • 60949110035 scopus 로고    scopus 로고
    • Therapeutic implications of the cancer stem cell hypothesis
    • Diehn M, Cho RW, Clarke MF. Therapeutic implications of the cancer stem cell hypothesis. Semin Radiat Oncol 2009; 19:78-86.
    • (2009) Semin Radiat Oncol , vol.19 , pp. 78-86
    • Diehn, M.1    Cho, R.W.2    Clarke, M.F.3
  • 10
    • 47549090432 scopus 로고    scopus 로고
    • TGFbeta in Cancer
    • Massague J. TGFbeta in Cancer. Cell 2008; 134:215-30.
    • (2008) Cell , vol.134 , pp. 215-230
    • Massague, J.1
  • 11
    • 59449090107 scopus 로고    scopus 로고
    • TGFbeta-induced epithelial to mesenchymal transition
    • Xu J, Lamouille S, Derynck R. TGFbeta-induced epithelial to mesenchymal transition. Cell Res 2009; 19:156-72.
    • (2009) Cell Res , vol.19 , pp. 156-172
    • Xu, J.1    Lamouille, S.2    Derynck, R.3
  • 12
    • 0034574298 scopus 로고    scopus 로고
    • How cells read TGFbeta signals
    • Massague J. How cells read TGFbeta signals. Nat Rev Mol Cell Biol 2000; 1:169-78.
    • (2000) Nat Rev Mol Cell Biol , vol.1 , pp. 169-178
    • Massague, J.1
  • 13
    • 33845334175 scopus 로고    scopus 로고
    • Actions of TGF-β as tumor suppressor and pro-metastatic factor in human cancer
    • DOI 10.1016/j.bbcan.2006.06.004, PII S0304419X06000357
    • Pardali K, Moustakas A. Actions of TGFbeta as tumor suppressor and pro-metastatic factor in human cancer. Biochim Biophys Acta 2007; 1775:21-62. (Pubitemid 44881193)
    • (2007) Biochimica et Biophysica Acta - Reviews on Cancer , vol.1775 , Issue.1 , pp. 21-62
    • Pardali, K.1    Moustakas, A.2
  • 14
    • 3142742249 scopus 로고    scopus 로고
    • Induction by transforming growth factor-beta1 of epithelial to mesenchymal transition is a rare event in vitro
    • Brown KA, Aakre ME, Gorska AE, Price JO, Eltom SE, Pietenpol JA, et al. Induction by transforming growth factor-beta1 of epithelial to mesenchymal transition is a rare event in vitro. Breast Cancer Res 2004; 6:215-31.
    • (2004) Breast Cancer Res , vol.6 , pp. 215-231
    • Brown, K.A.1    Aakre, M.E.2    Gorska, A.E.3    Price, J.O.4    Eltom, S.E.5    Pietenpol, J.A.6
  • 15
    • 0028603343 scopus 로고
    • TGFbeta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: Involvement of type I receptors
    • Miettinen PJ, Ebner R, Lopez AR, Derynck R. TGFbeta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors. J Cell Biol 1994; 127:2021-36.
    • (1994) J Cell Biol , vol.127 , pp. 2021-2036
    • Miettinen, P.J.1    Ebner, R.2    Lopez, A.R.3    Derynck, R.4
  • 16
    • 23144442645 scopus 로고    scopus 로고
    • Regulation of cadherin-mediated adhesion in morphogenesis
    • Gumbiner BM. Regulation of cadherin-mediated adhesion in morphogenesis. Nat Rev Mol Cell Biol 2005; 6:622-34.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 622-634
    • Gumbiner, B.M.1
  • 17
    • 0028245813 scopus 로고
    • Cadherin expression in carcinomas: Role in the formation of cell junctions and the prevention of invasiveness
    • DOI 10.1016/0304-419X(94)90003-5
    • Birchmeier W, Behrens J. Cadherin expression in carcinomas: role in the formation of cell junctions and the prevention of invasiveness. Biochim Biophys Acta 1994; 1198:11-26. (Pubitemid 24159061)
    • (1994) Biochimica et Biophysica Acta - Reviews on Cancer , vol.1198 , Issue.1 , pp. 11-26
    • Birchmeier, W.1    Behrens, J.2
  • 18
    • 0032510494 scopus 로고    scopus 로고
    • A causal role for E-cadherin in the transition from adenoma to carcinoma
    • Perl AK, Wilgenbus P, Dahl U, Semb H, Christofori G. A causal role for E-cadherin in the transition from adenoma to carcinoma. Nature 1998; 392:190-3.
    • (1998) Nature , vol.392 , pp. 190-193
    • Perl, A.K.1    Wilgenbus, P.2    Dahl, U.3    Semb, H.4    Christofori, G.5
  • 19
    • 34249289041 scopus 로고    scopus 로고
    • Snail, Zeb and bHLH factors in tumour progression: An alliance against the epithelial phenotype?
    • Peinado H, Olmeda D, Cano A. Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat Rev Cancer 2007; 7:415-28.
    • (2007) Nat Rev Cancer , vol.7 , pp. 415-428
    • Peinado, H.1    Olmeda, D.2    Cano, A.3
  • 20
    • 0036595629 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in tumour progression
    • Thiery JP. Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2002; 2:442-54.
    • (2002) Nat Rev Cancer , vol.2 , pp. 442-454
    • Thiery, J.P.1
  • 22
    • 0025765115 scopus 로고
    • E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells
    • Frixen UH, Behrens J, Sachs M, Eberle G, Voss B, Warda A, et al. E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells. J Cell Biol 1991; 113:173-85.
    • (1991) J Cell Biol , vol.113 , pp. 173-185
    • Frixen, U.H.1    Behrens, J.2    Sachs, M.3    Eberle, G.4    Voss, B.5    Warda, A.6
  • 23
    • 0025818032 scopus 로고
    • Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role
    • Vleminckx K, Vakaet L Jr, Mareel M, Fiers W, van Roy F. Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. Cell 1991; 66:107-19. (Pubitemid 121001351)
    • (1991) Cell , vol.66 , Issue.1 , pp. 107-119
    • Vleminckx, K.1    Vakaet Jr., L.2    Mareel, M.3    Fiers, W.4    Van Roy, F.5
  • 24
    • 40749151542 scopus 로고    scopus 로고
    • Repression of PTEN phosphatase by Snail1 transcriptional factor during gamma radiation-induced apoptosis
    • Escriva M, Peiro S, Herranz N, Villagrasa P, Dave N, Montserrat-Sentis B, et al. Repression of PTEN phosphatase by Snail1 transcriptional factor during gamma radiation-induced apoptosis. Mol Cell Biol 2008; 28:1528-40.
    • (2008) Mol Cell Biol , vol.28 , pp. 1528-1540
    • Escriva, M.1    Peiro, S.2    Herranz, N.3    Villagrasa, P.4    Dave, N.5    Montserrat-Sentis, B.6
  • 25
    • 4344662447 scopus 로고    scopus 로고
    • Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress
    • Kajita M, McClinic KN, Wade PA. Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress. Mol Cell Biol 2004; 24:7559-66.
    • (2004) Mol Cell Biol , vol.24 , pp. 7559-7566
    • Kajita, M.1    McClinic, K.N.2    Wade, P.A.3
  • 27
    • 60649089997 scopus 로고    scopus 로고
    • Cancer metastasis is accelerated through immunosuppression during Snail-induced EMT of cancer cells
    • Kudo-Saito C, Shirako H, Takeuchi T, Kawakami Y. Cancer metastasis is accelerated through immunosuppression during Snail-induced EMT of cancer cells. Cancer Cell 2009; 15:195-206.
    • (2009) Cancer Cell , vol.15 , pp. 195-206
    • Kudo-Saito, C.1    Shirako, H.2    Takeuchi, T.3    Kawakami, Y.4
  • 28
    • 25444495269 scopus 로고    scopus 로고
    • Opinion: Migrating cancer stem cells - An integrated concept of malignant tumour progression
    • Brabletz T, Jung A, Spaderna S, Hlubek F, Kirchner T. Opinion: migrating cancer stem cells - an integrated concept of malignant tumour progression. Nat Rev Cancer 2005; 5:744-9.
    • (2005) Nat Rev Cancer , vol.5 , pp. 744-749
    • Brabletz, T.1    Jung, A.2    Spaderna, S.3    Hlubek, F.4    Kirchner, T.5
  • 29
    • 22144497081 scopus 로고    scopus 로고
    • Invasion and metastasis in colorectal cancer: Epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and beta-catenin
    • Brabletz T, Hlubek F, Spaderna S, Schmalhofer O, Hiendlmeyer E, Jung A, et al. Invasion and metastasis in colorectal cancer: epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and beta-catenin. Cells Tissues Organs 2005; 179:56-65.
    • (2005) Cells Tissues Organs , vol.179 , pp. 56-65
    • Brabletz, T.1    Hlubek, F.2    Spaderna, S.3    Schmalhofer, O.4    Hiendlmeyer, E.5    Jung, A.6
  • 30
    • 63049123066 scopus 로고    scopus 로고
    • Transitions between epithelial and mesenchymal states: Acquisition of malignant and stem cell traits
    • Polyak K, Weinberg RA. Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits. Nat Rev Cancer 2009; 9:265-73.
    • (2009) Nat Rev Cancer , vol.9 , pp. 265-273
    • Polyak, K.1    Weinberg, R.A.2
  • 31
    • 75449106680 scopus 로고    scopus 로고
    • Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patients
    • Aktas B, Tewes M, Fehm T, Hauch S, Kimmig R, Kasimir-Bauer S. Stem cell and epithelial-mesenchymal transition markers are frequently overexpressed in circulating tumor cells of metastatic breast cancer patients. Breast Cancer Res 2009; 11:46.
    • (2009) Breast Cancer Res , vol.11 , pp. 46
    • Aktas, B.1    Tewes, M.2    Fehm, T.3    Hauch, S.4    Kimmig, R.5    Kasimir-Bauer, S.6
  • 32
    • 58149254759 scopus 로고    scopus 로고
    • ALDH1 as a Functional Marker of Cancer Stem and Progenitor Cells
    • Douville J, Beaulieu R, Balicki D. ALDH1 as a Functional Marker of Cancer Stem and Progenitor Cells. Stem Cells Dev 2008.
    • (2008) Stem Cells Dev
    • Douville, J.1    Beaulieu, R.2    Balicki, D.3
  • 33
    • 66249109653 scopus 로고    scopus 로고
    • Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics
    • Hennessy BT, Gonzalez-Angulo AM, Stemke-Hale K, Gilcrease MZ, Krishnamurthy S, Lee JS, et al. Characterization of a naturally occurring breast cancer subset enriched in epithelial-to-mesenchymal transition and stem cell characteristics. Cancer Res 2009; 69:4116-24.
    • (2009) Cancer Res , vol.69 , pp. 4116-4124
    • Hennessy, B.T.1    Gonzalez-Angulo, A.M.2    Stemke-Hale, K.3    Gilcrease, M.Z.4    Krishnamurthy, S.5    Lee, J.S.6
  • 34
    • 73149086829 scopus 로고    scopus 로고
    • CIP1 attenuates Ras- and c-Mycdependent breast tumor epithelial mesenchymal transition and cancer stem cell-like gene expression in vivo
    • CIP1 attenuates Ras- and c-Mycdependent breast tumor epithelial mesenchymal transition and cancer stem cell-like gene expression in vivo. Proc Natl Acad Sci USA 2009; 106:19035-9.
    • Proc Natl Acad Sci USA 2009 , vol.106 , pp. 19035-19039
    • Liu, M.1    Casimiro, M.C.2    Wang, C.3    Shirley, L.A.4    Jiao, X.5    Katiyar, S.6
  • 35
    • 70349859809 scopus 로고    scopus 로고
    • Snail and slug mediate radioresistance and chemoresistance by antagonizing p53-mediated apoptosis and acquiring a stem-like phenotype in ovarian cancer cells
    • Kurrey NK, Jalgaonkar SP, Joglekar AV, Ghanate AD, Chaskar PD, Doiphode RY, et al. Snail and slug mediate radioresistance and chemoresistance by antagonizing p53-mediated apoptosis and acquiring a stem-like phenotype in ovarian cancer cells. Stem Cells 2009; 27:2059-68.
    • (2009) Stem Cells , vol.27 , pp. 2059-2068
    • Kurrey, N.K.1    Jalgaonkar, S.P.2    Joglekar, A.V.3    Ghanate, A.D.4    Chaskar, P.D.5    Doiphode, R.Y.6
  • 36
    • 2342643464 scopus 로고    scopus 로고
    • Beta-Catenin and TGFbeta signalling cooperate to maintain a mesenchymal phenotype after FosER-induced epithelial to mesenchymal transition
    • Eger A, Stockinger A, Park J, Langkopf E, Mikula M, Gotzmann J, et al. beta-Catenin and TGFbeta signalling cooperate to maintain a mesenchymal phenotype after FosER-induced epithelial to mesenchymal transition. Oncogene 2004; 23:2672-80.
    • (2004) Oncogene , vol.23 , pp. 2672-2680
    • Eger, A.1    Stockinger, A.2    Park, J.3    Langkopf, E.4    Mikula, M.5    Gotzmann, J.6
  • 37
    • 1542347695 scopus 로고    scopus 로고
    • Convergence of Wnt, β-Catenin, and Cadherin pathways
    • DOI 10.1126/science.1094291
    • Nelson WJ, Nusse R. Convergence of Wnt, beta-catenin and cadherin pathways. Science (New York, NY) 2004; 303:1483-7. (Pubitemid 38314410)
    • (2004) Science , vol.303 , Issue.5663 , pp. 1483-1487
    • Nelson, W.J.1    Nusse, R.2
  • 39
    • 0043172396 scopus 로고    scopus 로고
    • Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis
    • Grunert S, Jechlinger M, Beug H. Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis. Nature reviews 2003; 4:657-65.
    • (2003) Nature Reviews , vol.4 , pp. 657-665
    • Grunert, S.1    Jechlinger, M.2    Beug, H.3
  • 42
    • 6944248910 scopus 로고    scopus 로고
    • Activation of the Erk pathway is required for TGFbeta1-induced EMT in vitro
    • New York, NY
    • Xie L, Law BK, Chytil AM, Brown KA, Aakre ME, Moses HL. Activation of the Erk pathway is required for TGFbeta1-induced EMT in vitro. Neoplasia (New York, NY) 2004; 6:603-10.
    • (2004) Neoplasia , vol.6 , pp. 603-610
    • Xie, L.1    Law, B.K.2    Chytil, A.M.3    Brown, K.A.4    Aakre, M.E.5    Moses, H.L.6
  • 44
    • 1842524153 scopus 로고    scopus 로고
    • Integration of TGFbeta/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition
    • Zavadil J, Cermak L, Soto-Nieves N, Bottinger EP. Integration of TGFbeta/Smad and Jagged1/Notch signalling in epithelial-to-mesenchymal transition. The EMBO journal 2004; 23:1155-65.
    • (2004) The EMBO Journal , vol.23 , pp. 1155-1165
    • Zavadil, J.1    Cermak, L.2    Soto-Nieves, N.3    Bottinger, E.P.4
  • 45
    • 0037148532 scopus 로고    scopus 로고
    • Ras and TGFβ cooperatively regulate epithelial cell plasticity and metastasis: Dissection of Ras signaling pathways
    • DOI 10.1083/jcb.200109037
    • Janda E, Lehmann K, Killisch I, Jechlinger M, Herzig M, Downward J, et al. Ras and TGF[beta] cooperatively regulate epithelial cell plasticity and metastasis: dissection of Ras signaling pathways. J Cell Biol 2002; 156:299-313. (Pubitemid 34839911)
    • (2002) Journal of Cell Biology , vol.156 , Issue.2 , pp. 299-313
    • Janda, E.1    Lehmann, K.2    Killisch, I.3    Jechlinger, M.4    Herzig, M.5    Downward, J.6    Beug, H.7    Grunert, S.8
  • 46
    • 22144461325 scopus 로고    scopus 로고
    • Transforming growth factor-beta signaling during epithelial-mesenchymal transformation: Implications for embryogenesis and tumor metastasis
    • Nawshad A, Lagamba D, Polad A, Hay ED. Transforming growth factor-beta signaling during epithelial-mesenchymal transformation: implications for embryogenesis and tumor metastasis. Cells Tissues Organs 2005; 179:11-23.
    • (2005) Cells Tissues Organs , vol.179 , pp. 11-23
    • Nawshad, A.1    Lagamba, D.2    Polad, A.3    Hay, E.D.4
  • 47
    • 0032547895 scopus 로고    scopus 로고
    • TGFβ signaling is necessary for carcinoma cell invasiveness and metastasis
    • Oft M, Heider KH, Beug H. TGFbeta signaling is necessary for carcinoma cell invasiveness and metastasis. Curr Biol 1998; 8:1243-52. (Pubitemid 28540052)
    • (1998) Current Biology , vol.8 , Issue.23 , pp. 1243-1252
    • Oft, M.1    Heider, K.-H.2    Beug, H.3
  • 48
    • 7944235577 scopus 로고    scopus 로고
    • Diverse mechanisms regulate stem cell self-renewal
    • DOI 10.1016/j.ceb.2004.09.004, PII S0955067404001401
    • Molofsky AV, Pardal R, Morrison SJ. Diverse mechanisms regulate stem cell self-renewal. Curr Opin Cell Biol 2004; 16:700-7. (Pubitemid 39467731)
    • (2004) Current Opinion in Cell Biology , vol.16 , Issue.6 , pp. 700-707
    • Molofsky, A.V.1    Pardal, R.2    Morrison, S.J.3
  • 49
    • 59849120891 scopus 로고    scopus 로고
    • Control of stemness by fibroblast growth factor signaling in stem cells and cancer stem cells
    • Gotoh N. Control of stemness by fibroblast growth factor signaling in stem cells and cancer stem cells. Curr Stem Cell Res Ther 2009; 4:9-15.
    • (2009) Curr Stem Cell Res Ther , vol.4 , pp. 9-15
    • Gotoh, N.1
  • 50
    • 63749105896 scopus 로고    scopus 로고
    • Mechanism of TGFbeta signaling to growth arrest, apoptosis and epithelial-mesenchymal transition
    • Heldin CH, Landstrom M, Moustakas A. Mechanism of TGFbeta signaling to growth arrest, apoptosis and epithelial-mesenchymal transition. Current opinion in cell biology 2009; 21:166-76.
    • (2009) Current Opinion in Cell Biology , vol.21 , pp. 166-176
    • Heldin, C.H.1    Landstrom, M.2    Moustakas, A.3
  • 53
    • 0033377867 scopus 로고    scopus 로고
    • TGF(beta) type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells
    • Piek E, Moustakas A, Kurisaki A, Heldin CH, ten Dijke P. TGF(beta) type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells. J Cell Sci 1999; 112:4557-68.
    • (1999) J Cell Sci , vol.112 , pp. 4557-4568
    • Piek, E.1    Moustakas, A.2    Kurisaki, A.3    Heldin, C.H.4    Ten Dijke, P.5
  • 54
    • 16344378397 scopus 로고    scopus 로고
    • TGFbeta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition
    • Valcourt U, Kowanetz M, Niimi H, Heldin CH, Moustakas A. TGFbeta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition. Mol Biol Cell 2005; 16:1987-2002.
    • (2005) Mol Biol Cell , vol.16 , pp. 1987-2002
    • Valcourt, U.1    Kowanetz, M.2    Niimi, H.3    Heldin, C.H.4    Moustakas, A.5
  • 55
    • 0346727324 scopus 로고    scopus 로고
    • Targeted disruption of TGFbeta1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction
    • Sato M, Muragaki Y, Saika S, Roberts AB, Ooshima A. Targeted disruption of TGFbeta1/Smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction. J Clin Invest 2003; 112:1486-94.
    • (2003) J Clin Invest , vol.112 , pp. 1486-1494
    • Sato, M.1    Muragaki, Y.2    Saika, S.3    Roberts, A.B.4    Ooshima, A.5
  • 56
    • 0033195998 scopus 로고    scopus 로고
    • Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response
    • Ashcroft GS, Yang X, Glick AB, Weinstein M, Letterio JL, Mizel DE, et al. Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response. Nat Cell Biol 1999; 1:260-6.
    • (1999) Nat Cell Biol , vol.1 , pp. 260-266
    • Ashcroft, G.S.1    Yang, X.2    Glick, A.B.3    Weinstein, M.4    Letterio, J.L.5    Mizel, D.E.6
  • 57
    • 33644534795 scopus 로고    scopus 로고
    • The tumor suppressor Smad4 is required for transforming growth factor β-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells
    • DOI 10.1158/0008-5472.CAN-05-3560
    • Deckers M, van Dinther M, Buijs J, Que I, Lowik C, van der Pluijm G, et al. The tumor suppressor Smad4 is required for transforming growth factor beta-induced epithelial to mesenchymal transition and bone metastasis of breast cancer cells. Cancer Res 2006; 66:2202-9. (Pubitemid 43294931)
    • (2006) Cancer Research , vol.66 , Issue.4 , pp. 2202-2209
    • Deckers, M.1    Van Dinther, M.2    Buijs, J.3    Que, I.4    Lowik, C.5    Van Der Pluijm, G.6    Ten Dijke, P.7
  • 58
    • 34547599359 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 induces an epithelial-to-mesenchymal transition state in mouse hepatocytes in vitro
    • Kaimori A, Potter J, Kaimori JY, Wang C, Mezey E, Koteish A. Transforming growth factor-beta1 induces an epithelial-to-mesenchymal transition state in mouse hepatocytes in vitro. J Biol Chem 2007; 282:22089-101.
    • (2007) J Biol Chem , vol.282 , pp. 22089-22101
    • Kaimori, A.1    Potter, J.2    Kaimori, J.Y.3    Wang, C.4    Mezey, E.5    Koteish, A.6
  • 59
    • 34248674918 scopus 로고    scopus 로고
    • Smad4 is essential for downregulation of E-cadherin induced by TGFbeta in pancreatic cancer cell line PANC-1
    • Takano S, Kanai F, Jazag A, Ijichi H, Yao J, Ogawa H, et al. Smad4 is essential for downregulation of E-cadherin induced by TGFbeta in pancreatic cancer cell line PANC-1. J Biochem 2007; 141:345-51.
    • (2007) J Biochem , vol.141 , pp. 345-351
    • Takano, S.1    Kanai, F.2    Jazag, A.3    Ijichi, H.4    Yao, J.5    Ogawa, H.6
  • 60
    • 68249092353 scopus 로고    scopus 로고
    • A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGFbeta mediated epithelial-mesenchymal transition
    • Vincent T, Neve EP, Johnson JR, Kukalev A, Rojo F, Albanell J, et al. A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGFbeta mediated epithelial-mesenchymal transition. Nat Cell Biol 2009; 11:943-50.
    • (2009) Nat Cell Biol , vol.11 , pp. 943-950
    • Vincent, T.1    Neve, E.P.2    Johnson, J.R.3    Kukalev, A.4    Rojo, F.5    Albanell, J.6
  • 61
    • 33751251034 scopus 로고    scopus 로고
    • Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer
    • Bardeesy N, Cheng KH, Berger JH, Chu GC, Pahler J, Olson P, et al. Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer. Genes Dev 2006; 20:3130-46.
    • (2006) Genes Dev , vol.20 , pp. 3130-3146
    • Bardeesy, N.1    Cheng, K.H.2    Berger, J.H.3    Chu, G.C.4    Pahler, J.5    Olson, P.6
  • 62
    • 67650496215 scopus 로고    scopus 로고
    • A novel lung metastasis signature links Wnt signaling with cancer cell self-renewal and epithelial-mesenchymal transition in basal-like breast cancer
    • DiMeo TA, Anderson K, Phadke P, Fan C, Perou CM, Naber S, et al. A novel lung metastasis signature links Wnt signaling with cancer cell self-renewal and epithelial-mesenchymal transition in basal-like breast cancer. Cancer Res 2009; 69:5364-73.
    • (2009) Cancer Res , vol.69 , pp. 5364-5373
    • DiMeo, T.A.1    Anderson, K.2    Phadke, P.3    Fan, C.4    Perou, C.M.5    Naber, S.6
  • 64
    • 70349205537 scopus 로고    scopus 로고
    • Six1 expands the mouse mammary epithelial stem/progenitor cell pool and induces mammary tumors that undergo epithelial-mesenchymal transition
    • McCoy EL, Iwanaga R, Jedlicka P, Abbey NS, Chodosh LA, Heichman KA, et al. Six1 expands the mouse mammary epithelial stem/progenitor cell pool and induces mammary tumors that undergo epithelial-mesenchymal transition. J Clin Invest 2009; 119:2663-77.
    • (2009) J Clin Invest , vol.119 , pp. 2663-2677
    • McCoy, E.L.1    Iwanaga, R.2    Jedlicka, P.3    Abbey, N.S.4    Chodosh, L.A.5    Heichman, K.A.6
  • 65
    • 67650594771 scopus 로고    scopus 로고
    • The opposing roles of Wnt-5a in cancer
    • 14.
    • McDonald SL, Silver A. The opposing roles of Wnt-5a in cancer. Br J Cancer 2009; 101:209-14.
    • (2009) Br J Cancer , vol.101 , Issue.209
    • McDonald, S.L.1    Silver, A.2
  • 66
    • 33846193290 scopus 로고    scopus 로고
    • The many ways of Wnt in cancer
    • Polakis P. The many ways of Wnt in cancer. Curr Opin Genet Dev 2007; 17:45-51.
    • (2007) Curr Opin Genet Dev , vol.17 , pp. 45-51
    • Polakis, P.1
  • 67
    • 77954445464 scopus 로고    scopus 로고
    • Epigenetic silencing of SFRP5 is related to malignant phenotype and chemoresistance of ovarian cancer through Wnt signaling pathway
    • Su HY, Lai HC, Lin YW, Liu CY, Chen CK, Chou YC, et al. Epigenetic silencing of SFRP5 is related to malignant phenotype and chemoresistance of ovarian cancer through Wnt signaling pathway. Int J Cancer 2009.
    • (2009) Int J Cancer
    • Su, H.Y.1    Lai, H.C.2    Lin, Y.W.3    Liu, C.Y.4    Chen, C.K.5    Chou, Y.C.6
  • 69
    • 67650230896 scopus 로고    scopus 로고
    • Wnt/beta-catenin signaling: Components, mechanisms and diseases
    • MacDonald BT, Tamai K, He X. Wnt/beta-catenin signaling: components, mechanisms and diseases. Dev Cell 2009; 17:9-26.
    • (2009) Dev Cell , vol.17 , pp. 9-26
    • MacDonald, B.T.1    Tamai, K.2    He, X.3
  • 70
    • 77149174855 scopus 로고    scopus 로고
    • Wnt signaling from development to disease: Insights from model systems
    • Cadigan KM, Peifer M. Wnt signaling from development to disease: insights from model systems. Cold Spring Harb Perspect Biol 2009; 1:2881.
    • (2009) Cold Spring Harb Perspect Biol , vol.1 , pp. 2881
    • Cadigan, K.M.1    Peifer, M.2
  • 72
    • 77149174855 scopus 로고    scopus 로고
    • Wnt signaling from development to disease: Insights from model systems
    • Cadigan KM, Peifer M. Wnt signaling from development to disease: insights from model systems. Cold Spring Harbor Perspect Biol 2009; 1:2881.
    • (2009) Cold Spring Harbor Perspect Biol , vol.1 , pp. 2881
    • Cadigan, K.M.1    Peifer, M.2
  • 73
    • 65849401051 scopus 로고    scopus 로고
    • The tortoise and the hair: Slow-cycling cells in the stem cell race
    • Fuchs E. The tortoise and the hair: slow-cycling cells in the stem cell race. Cell 2009; 137:811-9.
    • (2009) Cell , vol.137 , pp. 811-819
    • Fuchs, E.1
  • 74
    • 0030949463 scopus 로고    scopus 로고
    • Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC
    • DOI 10.1126/science.275.5307.1787
    • Morin PJ, Sparks AB, Korinek V, Barker N, Clevers H, Vogelstein B, et al. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science 1997; 275:1787-90. (Pubitemid 27136715)
    • (1997) Science , vol.275 , Issue.5307 , pp. 1787-1790
    • Morin, P.J.1    Sparks, A.B.2    Korinek, V.3    Barker, N.4    Clevers, H.5    Vogelstein, B.6    Kinzler, K.W.7
  • 75
    • 68549106083 scopus 로고    scopus 로고
    • E-cadherin, beta-catenin and ZEB1 in malignant progression of cancer
    • Schmalhofer O, Brabletz S, Brabletz T. E-cadherin, beta-catenin and ZEB1 in malignant progression of cancer. Cancer Metastasis Rev 2009; 28:151-66.
    • (2009) Cancer Metastasis Rev , vol.28 , pp. 151-166
    • Schmalhofer, O.1    Brabletz, S.2    Brabletz, T.3
  • 76
    • 34250744600 scopus 로고    scopus 로고
    • Role of glycogen synthase kinase-3 in cell fate and epithelial- mesenchymal transitions
    • Doble BW, Woodgett JR. Role of glycogen synthase kinase-3 in cell fate and epithelial-mesenchymal transitions. Cells Tissues Organs 2007; 185:73-84.
    • (2007) Cells Tissues Organs , vol.185 , pp. 73-84
    • Doble, B.W.1    Woodgett, J.R.2
  • 77
    • 5444269904 scopus 로고    scopus 로고
    • Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition
    • Zhou BP, Deng J, Xia W, Xu J, Li YM, Gunduz M, et al. Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. Nat Cell Biol 2004; 6:931-40.
    • (2004) Nat Cell Biol , vol.6 , pp. 931-940
    • Zhou, B.P.1    Deng, J.2    Xia, W.3    Xu, J.4    Li, Y.M.5    Gunduz, M.6
  • 78
    • 12144266241 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: Implications for the epithelial-mesenchymal transition
    • Bachelder RE, Yoon SO, Franci C, de Herreros AG, Mercurio AM. Glycogen synthase kinase-3 is an endogenous inhibitor of Snail transcription: implications for the epithelial-mesenchymal transition. J Cell Biol 2005; 168:29-33.
    • (2005) J Cell Biol , vol.168 , pp. 29-33
    • Bachelder, R.E.1    Yoon, S.O.2    Franci, C.3    De Herreros, A.G.4    Mercurio, A.M.5
  • 80
    • 58549105508 scopus 로고    scopus 로고
    • Ras alters epithelial-mesenchymal transition in response to TGFbeta by reducing actin fibers and cell-matrix adhesion
    • Safina AF, Varga AE, Bianchi A, Zheng Q, Kunnev D, Liang P, et al. Ras alters epithelial-mesenchymal transition in response to TGFbeta by reducing actin fibers and cell-matrix adhesion. Cell Cycle 2009; 8:284-98.
    • (2009) Cell Cycle , vol.8 , pp. 284-298
    • Safina, A.F.1    Varga, A.E.2    Bianchi, A.3    Zheng, Q.4    Kunnev, D.5    Liang, P.6
  • 81
    • 0035872426 scopus 로고    scopus 로고
    • Transforming growth factor beta1 treatment leads to an epithelial-mesenchymal transdifferentiation of pancreatic cancer cells requiring extracellular signal-regulated kinase 2 activation
    • Ellenrieder V, Hendler SF, Boeck W, Seufferlein T, Menke A, Ruhland C, et al. Transforming growth factor beta1 treatment leads to an epithelial- mesenchymal transdifferentiation of pancreatic cancer cells requiring extracellular signal-regulated kinase 2 activation. Cancer Res 2001; 61:4222-8.
    • (2001) Cancer Res , vol.61 , pp. 4222-4228
    • Ellenrieder, V.1    Hendler, S.F.2    Boeck, W.3    Seufferlein, T.4    Menke, A.5    Ruhland, C.6
  • 82
    • 0036304111 scopus 로고    scopus 로고
    • Metastasis is driven by sequential elevation of H-ras and Smad2 levels
    • Oft M, Akhurst RJ, Balmain A. Metastasis is driven by sequential elevation of H-ras and Smad2 levels. Nat Cell Biol 2002; 4:487-94. (Pubitemid 34752433)
    • (2002) Nature Cell Biology , vol.4 , Issue.7 , pp. 487-494
    • Oft, M.1    Akhurst, R.J.2    Balmain, A.3
  • 83
    • 77949903708 scopus 로고    scopus 로고
    • Smad3 protein levels are modulated by Ras activity and during the cell cycle to dictate transforming growth factor-beta responses
    • Daly AC, Vizan P, Hill CS. Smad3 protein levels are modulated by Ras activity and during the cell cycle to dictate transforming growth factor-beta responses. J Biol Chem 2010; 285:6489-97.
    • (2010) J Biol Chem , vol.285 , pp. 6489-6497
    • Daly, A.C.1    Vizan, P.2    Hill, C.S.3
  • 84
    • 68049135877 scopus 로고    scopus 로고
    • A molecular signature for Epithelial to Mesenchymal transition in a human colon cancer cell system is revealed by large-scale microarray analysis
    • Joyce T, Cantarella D, Isella C, Medico E, Pintzas A. A molecular signature for Epithelial to Mesenchymal transition in a human colon cancer cell system is revealed by large-scale microarray analysis. Clin Exp Metastasis 2009; 26:569-87.
    • (2009) Clin Exp Metastasis , vol.26 , pp. 569-587
    • Joyce, T.1    Cantarella, D.2    Isella, C.3    Medico, E.4    Pintzas, A.5
  • 85
    • 1442278555 scopus 로고    scopus 로고
    • Expression of activated M-Ras in a murine mammary epithelial cell line induces epithelial-mesenchymal transition and tumorigenesis
    • Ward KR, Zhang KX, Somasiri AM, Roskelley CD, Schrader JW. Expression of activated M-Ras in a murine mammary epithelial cell line induces epithelial-mesenchymal transition and tumorigenesis. Oncogene 2004; 23:1187-96.
    • (2004) Oncogene , vol.23 , pp. 1187-1196
    • Ward, K.R.1    Zhang, K.X.2    Somasiri, A.M.3    Roskelley, C.D.4    Schrader, J.W.5
  • 86
    • 62549159932 scopus 로고    scopus 로고
    • HMGA2 maintains oncogenic RAS-induced epithelial-mesenchymal transition in human pancreatic cancer cells
    • Watanabe S, Ueda Y, Akaboshi S, Hino Y, Sekita Y, Nakao M. HMGA2 maintains oncogenic RAS-induced epithelial-mesenchymal transition in human pancreatic cancer cells. Am J Pathol 2009; 174:854-68.
    • (2009) Am J Pathol , vol.174 , pp. 854-868
    • Watanabe, S.1    Ueda, Y.2    Akaboshi, S.3    Hino, Y.4    Sekita, Y.5    Nakao, M.6
  • 88
    • 57749114754 scopus 로고    scopus 로고
    • HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition
    • Thuault S, Tan EJ, Peinado H, Cano A, Heldin CH, Moustakas A. HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to- mesenchymal transition. J Biol Chem 2008; 283:33437-46.
    • (2008) J Biol Chem , vol.283 , pp. 33437-33446
    • Thuault, S.1    Tan, E.J.2    Peinado, H.3    Cano, A.4    Heldin, C.H.5    Moustakas, A.6
  • 89
    • 59649107672 scopus 로고    scopus 로고
    • ILEI requires oncogenic Ras for the epithelial to mesenchymal transition of hepatocytes and liver carcinoma progression
    • Lahsnig C, Mikula M, Petz M, Zulehner G, Schneller D, van Zijl F, et al. ILEI requires oncogenic Ras for the epithelial to mesenchymal transition of hepatocytes and liver carcinoma progression. Oncogene 2009; 28:638-50.
    • (2009) Oncogene , vol.28 , pp. 638-650
    • Lahsnig, C.1    Mikula, M.2    Petz, M.3    Zulehner, G.4    Schneller, D.5    Van Zijl, F.6
  • 90
    • 57349178376 scopus 로고    scopus 로고
    • Restoration of E-cadherin cellcell junctions requires both expression of E-cadherin and suppression of ERK MAP kinase activation in Ras-transformed breast epithelial cells
    • Li Q, Mattingly RR. Restoration of E-cadherin cellcell junctions requires both expression of E-cadherin and suppression of ERK MAP kinase activation in Ras-transformed breast epithelial cells. Neoplasia 2008; 10:1444-58.
    • (2008) Neoplasia , vol.10 , pp. 1444-1458
    • Li, Q.1    Mattingly, R.R.2
  • 91
    • 33751087736 scopus 로고    scopus 로고
    • Raf plus TGFbeta-dependent EMT is initiated by endocytosis and lysosomal degradation of E-cadherin
    • Janda E, Nevolo M, Lehmann K, Downward J, Beug H, Grieco M. Raf plus TGFbeta-dependent EMT is initiated by endocytosis and lysosomal degradation of E-cadherin. Oncogene 2006; 25:7117-30.
    • (2006) Oncogene , vol.25 , pp. 7117-7130
    • Janda, E.1    Nevolo, M.2    Lehmann, K.3    Downward, J.4    Beug, H.5    Grieco, M.6
  • 92
    • 68949210380 scopus 로고    scopus 로고
    • RSK is a principal effector of the RASERK pathway for eliciting a coordinate promotile/ invasive gene program and phenotype in epithelial cells
    • Doehn U, Hauge C, Frank SR, Jensen CJ, Duda K, Nielsen JV, et al. RSK is a principal effector of the RASERK pathway for eliciting a coordinate promotile/ invasive gene program and phenotype in epithelial cells. Mol Cell 2009; 35:511-22.
    • (2009) Mol Cell , vol.35 , pp. 511-522
    • Doehn, U.1    Hauge, C.2    Frank, S.R.3    Jensen, C.J.4    Duda, K.5    Nielsen, J.V.6
  • 93
    • 65349116534 scopus 로고    scopus 로고
    • Translational activation of snail1 and other developmentally regulated transcription factors by YB-1 promotes an epithelial-mesenchymal transition
    • Evdokimova V, Tognon C, Ng T, Ruzanov P, Melnyk N, Fink D, et al. Translational activation of snail1 and other developmentally regulated transcription factors by YB-1 promotes an epithelial-mesenchymal transition. Cancer Cell 2009; 15:402-15.
    • (2009) Cancer Cell , vol.15 , pp. 402-415
    • Evdokimova, V.1    Tognon, C.2    Ng, T.3    Ruzanov, P.4    Melnyk, N.5    Fink, D.6
  • 94
    • 77953809781 scopus 로고    scopus 로고
    • Oncogenic RAS alters the global and gene-specific histone modification pattern during epithelial-mesenchymal transition in colorectal carcinoma cells
    • Mazon Pelaez I, Kalogeropoulou M, Ferraro A, Voulgari A, Pankotai T, Boros I, et al. Oncogenic RAS alters the global and gene-specific histone modification pattern during epithelial-mesenchymal transition in colorectal carcinoma cells. Int J Biochem Cell Biol.
    • Int J Biochem Cell Biol
    • Mazon Pelaez, I.1    Kalogeropoulou, M.2    Ferraro, A.3    Voulgari, A.4    Pankotai, T.5    Boros, I.6
  • 95
    • 34250727945 scopus 로고    scopus 로고
    • Chromatin structure regulation in transforming growth factor-beta-directed epithelial-mesenchymal transition
    • Blumenberg M, Gao S, Dickman K, Grollman AP, Bottinger EP, Zavadil J. Chromatin structure regulation in transforming growth factor-beta-directed epithelial-mesenchymal transition. Cells Tissues Organs 2007; 185:162-74.
    • (2007) Cells Tissues Organs , vol.185 , pp. 162-174
    • Blumenberg, M.1    Gao, S.2    Dickman, K.3    Grollman, A.P.4    Bottinger, E.P.5    Zavadil, J.6
  • 96
    • 34548526743 scopus 로고    scopus 로고
    • Chromatin remodeling and cancer, Part I: Covalent histone modifications
    • Wang GG, Allis CD, Chi P. Chromatin remodeling and cancer, Part I: Covalent histone modifications. Trends Mol Med 2007; 13:363-72.
    • (2007) Trends Mol Med , vol.13 , pp. 363-372
    • Wang, G.G.1    Allis, C.D.2    Chi, P.3
  • 97
    • 0029083459 scopus 로고
    • Progression of carcinoma cells is associated with alterations in chromatin structure and factor binding at the E-cadherin promoter in vivo
    • Hennig G, Behrens J, Truss M, Frisch S, Reichmann E, Birchmeier W. Progression of carcinoma cells is associated with alterations in chromatin structure and factor binding at the E-cadherin promoter in vivo. Oncogene 1995; 11:475-84.
    • (1995) Oncogene , vol.11 , pp. 475-484
    • Hennig, G.1    Behrens, J.2    Truss, M.3    Frisch, S.4    Reichmann, E.5    Birchmeier, W.6
  • 98
    • 0030066481 scopus 로고    scopus 로고
    • Mechanisms identified in the transcriptional control of epithelial gene expression
    • Hennig G, Lowrick O, Birchmeier W, Behrens J. Mechanisms identified in the transcriptional control of epithelial gene expression. J Biol Chem 1996; 271:595-602.
    • (1996) J Biol Chem , vol.271 , pp. 595-602
    • Hennig, G.1    Lowrick, O.2    Birchmeier, W.3    Behrens, J.4
  • 99
    • 0033789680 scopus 로고    scopus 로고
    • The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells
    • Batlle E, Sancho E, Franci C, Dominguez D, Monfar M, Baulida J, et al. The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells. Nat Cell Biol 2000; 2:84-9.
    • (2000) Nat Cell Biol , vol.2 , pp. 84-89
    • Batlle, E.1    Sancho, E.2    Franci, C.3    Dominguez, D.4    Monfar, M.5    Baulida, J.6
  • 100
    • 0033784843 scopus 로고    scopus 로고
    • The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression
    • Cano A, Perez-Moreno MA, Rodrigo I, Locascio A, Blanco MJ, del Barrio MG, et al. The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat Cell Biol 2000; 2:76-83.
    • (2000) Nat Cell Biol , vol.2 , pp. 76-83
    • Cano, A.1    Perez-Moreno, M.A.2    Rodrigo, I.3    Locascio, A.4    Blanco, M.J.5    Del Barrio, M.G.6
  • 101
    • 0037086277 scopus 로고    scopus 로고
    • The SLUG zincfinger protein represses E-cadherin in breast cancer
    • Hajra KM, Chen DY, Fearon ER. The SLUG zincfinger protein represses E-cadherin in breast cancer. Cancer Res 2002; 62:1613-8.
    • (2002) Cancer Res , vol.62 , pp. 1613-1618
    • Hajra, K.M.1    Chen, D.Y.2    Fearon, E.R.3
  • 102
    • 0035920152 scopus 로고    scopus 로고
    • A new role for E12/ E47 in the repression of E-cadherin expression and epithelial-mesenchymal transitions
    • Perez-Moreno MA, Locascio A, Rodrigo I, Dhondt G, Portillo F, Nieto MA, et al. A new role for E12/ E47 in the repression of E-cadherin expression and epithelial-mesenchymal transitions. J Biol Chem 2001; 276:27424-31.
    • (2001) J Biol Chem , vol.276 , pp. 27424-27431
    • Perez-Moreno, M.A.1    Locascio, A.2    Rodrigo, I.3    Dhondt, G.4    Portillo, F.5    Nieto, M.A.6
  • 103
    • 0034964418 scopus 로고    scopus 로고
    • The two-handed e box binding zinc finger protein SIP1 downregulates e-cadherin and induces invasion
    • Comijn J, Berx G, Vermassen P, Verschueren K, van Grunsven L, Bruyneel E, et al. The two-handed E box binding zinc finger protein SIP1 downregulates E-cadherin and induces invasion. Mol Cell 2001; 7:1267-78.
    • (2001) Mol Cell , vol.7 , pp. 1267-1278
    • Comijn, J.1    Berx, G.2    Vermassen, P.3    Verschueren, K.4    Van Grunsven, L.5    Bruyneel, E.6
  • 104
    • 20144388095 scopus 로고    scopus 로고
    • DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells
    • Eger A, Aigner K, Sonderegger S, Dampier B, Oehler S, Schreiber M, et al. DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells. Oncogene 2005; 24:2375-85.
    • (2005) Oncogene , vol.24 , pp. 2375-2385
    • Eger, A.1    Aigner, K.2    Sonderegger, S.3    Dampier, B.4    Oehler, S.5    Schreiber, M.6
  • 105
    • 22244432840 scopus 로고    scopus 로고
    • The transcription factor snail induces tumor cell invasion through modulation of the epithelial cell differentiation program
    • De Craene B, Gilbert B, Stove C, Bruyneel E, van Roy F, Berx G. The transcription factor snail induces tumor cell invasion through modulation of the epithelial cell differentiation program. Cancer Res 2005; 65:6237-44.
    • (2005) Cancer Res , vol.65 , pp. 6237-6244
    • De Craene, B.1    Gilbert, B.2    Stove, C.3    Bruyneel, E.4    Van Roy, F.5    Berx, G.6
  • 106
    • 33750123430 scopus 로고    scopus 로고
    • Nuclear and cytoplasmic c-Ski differently modulate cellular functions
    • Nagata M, Goto K, Ehata S, Kobayashi N, Saitoh M, Miyoshi H, et al. Nuclear and cytoplasmic c-Ski differently modulate cellular functions. Genes Cells 2006; 11:1267-80.
    • (2006) Genes Cells , vol.11 , pp. 1267-1280
    • Nagata, M.1    Goto, K.2    Ehata, S.3    Kobayashi, N.4    Saitoh, M.5    Miyoshi, H.6
  • 108
    • 0038756636 scopus 로고    scopus 로고
    • Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: Mechanisms for epithelial mesenchymal transitions
    • Peinado H, Quintanilla M, Cano A. Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions. J Biol Chem 2003; 278:21113-23.
    • (2003) J Biol Chem , vol.278 , pp. 21113-21123
    • Peinado, H.1    Quintanilla, M.2    Cano, A.3
  • 109
    • 15744374449 scopus 로고    scopus 로고
    • Wnt-dependent regulation of the E-cadherin repressor snail
    • Yook JI, Li XY, Ota I, Fearon ER, Weiss SJ. Wnt-dependent regulation of the E-cadherin repressor snail. J Biol Chem 2005; 280:11740-8.
    • (2005) J Biol Chem , vol.280 , pp. 11740-11748
    • Yook, J.I.1    Li, X.Y.2    Ota, I.3    Fearon, E.R.4    Weiss, S.J.5
  • 110
    • 33751514601 scopus 로고    scopus 로고
    • A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells
    • Yook JI, Li XY, Ota I, Hu C, Kim HS, Kim NH, et al. A Wnt-Axin2-GSK3beta cascade regulates Snail1 activity in breast cancer cells. Nat Cell Biol 2006; 8:1398-406.
    • (2006) Nat Cell Biol , vol.8 , pp. 1398-1406
    • Yook, J.I.1    Li, X.Y.2    Ota, I.3    Hu, C.4    Kim, H.S.5    Kim, N.H.6
  • 111
    • 70350143237 scopus 로고    scopus 로고
    • Slug is a downstream mediator of transforming growth factor-beta1-induced matrix metalloproteinase-9 expression and invasion of oral cancer cells
    • Joseph MJ, Dangi-Garimella S, Shields MA, Diamond ME, Sun L, Koblinski JE, et al. Slug is a downstream mediator of transforming growth factor-beta1-induced matrix metalloproteinase-9 expression and invasion of oral cancer cells. J Cell Biochem 2009; 108:726-36.
    • (2009) J Cell Biochem , vol.108 , pp. 726-736
    • Joseph, M.J.1    Dangi-Garimella, S.2    Shields, M.A.3    Diamond, M.E.4    Sun, L.5    Koblinski, J.E.6
  • 112
    • 0345599013 scopus 로고    scopus 로고
    • Autoregulation of E-cadherin expression by cadherin-cadherin interactions: The roles of beta-catenin signaling, Slug, and MAPK
    • Conacci-Sorrell M, Simcha I, Ben-Yedidia T, Blechman J, Savagner P, Ben-Ze'ev A. Autoregulation of E-cadherin expression by cadherin-cadherin interactions: the roles of beta-catenin signaling, Slug, and MAPK. J Cell Biol 2003; 163:847-57.
    • (2003) J Cell Biol , vol.163 , pp. 847-857
    • Conacci-Sorrell, M.1    Simcha, I.2    Ben-Yedidia, T.3    Blechman, J.4    Savagner, P.5    Ben-Ze'ev, A.6
  • 113
    • 0035839534 scopus 로고    scopus 로고
    • Cloning and characterization of three Xenopus slug promoters reveal direct regulation by Lef/ beta-catenin signaling
    • Vallin J, Thuret R, Giacomello E, Faraldo MM, Thiery JP, Broders F. Cloning and characterization of three Xenopus slug promoters reveal direct regulation by Lef/ beta-catenin signaling. J Biol Chem 2001; 276:30350-8.
    • (2001) J Biol Chem , vol.276 , pp. 30350-30358
    • Vallin, J.1    Thuret, R.2    Giacomello, E.3    Faraldo, M.M.4    Thiery, J.P.5    Broders, F.6
  • 114
    • 34548496683 scopus 로고    scopus 로고
    • Differential regulation of epithelial and mesenchymal markers by deltaEF1 proteins in epithelial mesenchymal transition induced by TGFbeta
    • Shirakihara T, Saitoh M, Miyazono K. Differential regulation of epithelial and mesenchymal markers by deltaEF1 proteins in epithelial mesenchymal transition induced by TGFbeta. Mol Biol Cell 2007; 18:3533-44.
    • (2007) Mol Biol Cell , vol.18 , pp. 3533-3544
    • Shirakihara, T.1    Saitoh, M.2    Miyazono, K.3
  • 115
    • 0038324071 scopus 로고    scopus 로고
    • Opposing functions of ZEB proteins in the regulation of the TGFbeta/BMP signaling pathway
    • Postigo AA. Opposing functions of ZEB proteins in the regulation of the TGFbeta/BMP signaling pathway. EMBO J 2003; 22:2443-52.
    • (2003) EMBO J , vol.22 , pp. 2443-2452
    • Postigo, A.A.1
  • 117
    • 2942707848 scopus 로고    scopus 로고
    • Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis
    • Yang J, Mani SA, Donaher JL, Ramaswamy S, Itzykson RA, Come C, et al. Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell 2004; 117:927-39.
    • (2004) Cell , vol.117 , pp. 927-939
    • Yang, J.1    Mani, S.A.2    Donaher, J.L.3    Ramaswamy, S.4    Itzykson, R.A.5    Come, C.6
  • 118
    • 21244437500 scopus 로고    scopus 로고
    • Expression of the transcription factors snail, slug, and twist and their clinical significance in human breast cancer
    • DOI 10.1245/ASO.2005.04.010
    • Martin TA, Goyal A, Watkins G, Jiang WG. Expression of the transcription factors snail, slug and twist and their clinical significance in human breast cancer. Ann Surg Oncol 2005; 12:488-96. (Pubitemid 40884264)
    • (2005) Annals of Surgical Oncology , vol.12 , Issue.6 , pp. 488-496
    • Martin, T.A.1    Goyal, A.2    Watkins, G.3    Jiang, W.G.4
  • 119
    • 28344444026 scopus 로고    scopus 로고
    • Twist overexpression induces in vivo angiogenesis and correlates with chromosomal instability in breast cancer
    • Mironchik Y, Winnard PT Jr, Vesuna F, Kato Y, Wildes F, Pathak AP, et al. Twist overexpression induces in vivo angiogenesis and correlates with chromosomal instability in breast cancer. Cancer Res 2005; 65:10801-9.
    • (2005) Cancer Res , vol.65 , pp. 10801-10809
    • Mironchik, Y.1    Winnard Jr., P.T.2    Vesuna, F.3    Kato, Y.4    Wildes, F.5    Pathak, A.P.6
  • 120
    • 38349023012 scopus 로고    scopus 로고
    • Twist is a transcriptional repressor of E-cadherin gene expression in breast cancer
    • Vesuna F, van Diest P, Chen JH, Raman V. Twist is a transcriptional repressor of E-cadherin gene expression in breast cancer. Biochem Biophys Res Commun 2008; 367:235-41.
    • (2008) Biochem Biophys Res Commun , vol.367 , pp. 235-241
    • Vesuna, F.1    Van Diest, P.2    Chen, J.H.3    Raman, V.4
  • 121
    • 44449144396 scopus 로고    scopus 로고
    • Epithelial-Mesenchymal Transition: At the Crossroads of Development and Tumor Metastasis
    • DOI 10.1016/j.devcel.2008.05.009, PII S1534580708002098
    • Yang J, Weinberg RA. Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev Cell 2008; 14:818-29. (Pubitemid 351757205)
    • (2008) Developmental Cell , vol.14 , Issue.6 , pp. 818-829
    • Yang, J.1    Weinberg, R.A.2
  • 122
    • 45849087087 scopus 로고    scopus 로고
    • Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence
    • Ansieau S, Bastid J, Doreau A, Morel AP, Bouchet BP, Thomas C, et al. Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence. Cancer Cell 2008; 14:79-89.
    • (2008) Cancer Cell , vol.14 , pp. 79-89
    • Ansieau, S.1    Bastid, J.2    Doreau, A.3    Morel, A.P.4    Bouchet, B.P.5    Thomas, C.6
  • 123
    • 33947192053 scopus 로고    scopus 로고
    • Twist transcriptionally upregulates AKT2 in breast cancer cells leading to increased migration, invasion and resistance to paclitaxel
    • Cheng GZ, Chan J, Wang Q, Zhang W, Sun CD, Wang LH. Twist transcriptionally upregulates AKT2 in breast cancer cells leading to increased migration, invasion and resistance to paclitaxel. Cancer Res 2007; 67:1979-87.
    • (2007) Cancer Res , vol.67 , pp. 1979-1987
    • Cheng, G.Z.1    Chan, J.2    Wang, Q.3    Zhang, W.4    Sun, C.D.5    Wang, L.H.6
  • 124
    • 0033525094 scopus 로고    scopus 로고
    • Regulation of histone acetyltransferases p300 and PCAF by the bHLH protein twist and adenoviral oncoprotein E1A
    • Hamamori Y, Sartorelli V, Ogryzko V, Puri PL, Wu HY, Wang JY, et al. Regulation of histone acetyltransferases p300 and PCAF by the bHLH protein twist and adenoviral oncoprotein E1A. Cell 1999; 96:405-13.
    • (1999) Cell , vol.96 , pp. 405-413
    • Hamamori, Y.1    Sartorelli, V.2    Ogryzko, V.3    Puri, P.L.4    Wu, H.Y.5    Wang, J.Y.6
  • 125
    • 54549086654 scopus 로고    scopus 로고
    • The role of twist during palate development
    • Yu W, Kamara H, Svoboda KK. The role of twist during palate development. Dev Dyn 2008; 237:2716-25.
    • (2008) Dev Dyn , vol.237 , pp. 2716-2725
    • Yu, W.1    Kamara, H.2    Svoboda, K.K.3
  • 126
    • 57349137178 scopus 로고    scopus 로고
    • Fibulin-5 initiates epithelial-mesenchymal transition (EMT) and enhances EMT induced by TGFbeta in mammary epithelial cells via a MMP-dependent mechanism
    • Lee YH, Albig AR, Regner M, Schiemann BJ, Schiemann WP. Fibulin-5 initiates epithelial-mesenchymal transition (EMT) and enhances EMT induced by TGFbeta in mammary epithelial cells via a MMP-dependent mechanism. Carcinogenesis 2008; 29:2243-51.
    • (2008) Carcinogenesis , vol.29 , pp. 2243-2251
    • Lee, Y.H.1    Albig, A.R.2    Regner, M.3    Schiemann, B.J.4    Schiemann, W.P.5
  • 127
    • 47749131186 scopus 로고    scopus 로고
    • TWIST activation by hypoxia inducible factor-1 (HIF-1): Implications in metastasis and development
    • Yang MH, Wu KJ. TWIST activation by hypoxia inducible factor-1 (HIF-1): implications in metastasis and development. Cell Cycle 2008; 7:2090-6.
    • (2008) Cell Cycle , vol.7 , pp. 2090-2096
    • Yang, M.H.1    Wu, K.J.2
  • 128
    • 0345700653 scopus 로고    scopus 로고
    • Twist is up-regulated in response to Wnt1 and inhibits mouse mammary cell differentiation
    • Howe LR, Watanabe O, Leonard J, Brown AM. Twist is upregulated in response to Wnt1 and inhibits mouse mammary cell differentiation. Cancer Res 2003; 63:1906-13. (Pubitemid 36460857)
    • (2003) Cancer Research , vol.63 , Issue.8 , pp. 1906-1913
    • Howe, L.R.1    Watanabe, O.2    Leonard, J.3    Brown, A.M.C.4
  • 129
    • 34547620873 scopus 로고    scopus 로고
    • Kruppel-like factor 8 induces epithelial to mesenchymal transition and epithelial cell invasion
    • Wang X, Zheng M, Liu G, Xia W, McKeown-Longo PJ, Hung MC, et al. Kruppel-like factor 8 induces epithelial to mesenchymal transition and epithelial cell invasion. Cancer Res 2007; 67:7184-93.
    • (2007) Cancer Res , vol.67 , pp. 7184-7193
    • Wang, X.1    Zheng, M.2    Liu, G.3    Xia, W.4    McKeown-Longo, P.J.5    Hung, M.C.6
  • 130
    • 0141595045 scopus 로고    scopus 로고
    • Synergistic cooperation between the AP-1 and LEF-1 transcription factors in activation of the matrilysin promoter by the src oncogene: Implications in cellular invasion
    • Rivat C, Le Floch N, Sabbah M, Teyrol I, Redeuilh G, Bruyneel E, et al. Synergistic cooperation between the AP-1 and LEF-1 transcription factors in activation of the matrilysin promoter by the src oncogene: implications in cellular invasion. Faseb J 2003; 17:1721-3.
    • (2003) Faseb J , vol.17 , pp. 1721-1723
    • Rivat, C.1    Le Floch, N.2    Sabbah, M.3    Teyrol, I.4    Redeuilh, G.5    Bruyneel, E.6
  • 131
    • 0028144846 scopus 로고
    • C-Fos transcriptional activity stimulated by H-Ras-activated protein kinase distinct from JNK and ERK
    • Deng T, Karin M. c-Fos transcriptional activity stimulated by H-Ras-activated protein kinase distinct from JNK and ERK. Nature 1994; 371:171-5.
    • (1994) Nature , vol.371 , pp. 171-175
    • Deng, T.1    Karin, M.2
  • 133
    • 13044281685 scopus 로고    scopus 로고
    • Target genes of beta-catenin-T cell-factor/ lymphoid-enhancer-factor signaling in human colorectal carcinomas
    • Mann B, Gelos M, Siedow A, Hanski ML, Gratchev A, Ilyas M, et al. Target genes of beta-catenin-T cell-factor/ lymphoid-enhancer-factor signaling in human colorectal carcinomas. Proc Natl Acad Sci USA 1999; 96:1603-8.
    • Proc Natl Acad Sci USA 1999 , vol.96 , pp. 1603-1608
    • Mann, B.1    Gelos, M.2    Siedow, A.3    Hanski, M.L.4    Gratchev, A.5    Ilyas, M.6
  • 134
    • 26444560222 scopus 로고    scopus 로고
    • Induction of an epithelial to mesenchymal transition in human immortal and malignant keratinocytes by TGFbeta1 involves MAPK, Smad and AP-1 signalling pathways
    • Davies M, Robinson M, Smith E, Huntley S, Prime S, Paterson I. Induction of an epithelial to mesenchymal transition in human immortal and malignant keratinocytes by TGFbeta1 involves MAPK, Smad and AP-1 signalling pathways. Journal of cellular biochemistry 2005; 95:918-31.
    • (2005) Journal of Cellular Biochemistry , vol.95 , pp. 918-931
    • Davies, M.1    Robinson, M.2    Smith, E.3    Huntley, S.4    Prime, S.5    Paterson, I.6
  • 135
    • 68549109483 scopus 로고    scopus 로고
    • Constitutively active MEK1 is sufficient to induce epithelial-to- mesenchymal transition in intestinal epithelial cells and to promote tumor invasion and metastasis
    • Lemieux E, Bergeron S, Durand V, Asselin C, Saucier C, Rivard N. Constitutively active MEK1 is sufficient to induce epithelial-to-mesenchymal transition in intestinal epithelial cells and to promote tumor invasion and metastasis. Int J Cancer 2009; 125:1575-86.
    • (2009) Int J Cancer , vol.125 , pp. 1575-1586
    • Lemieux, E.1    Bergeron, S.2    Durand, V.3    Asselin, C.4    Saucier, C.5    Rivard, N.6
  • 136
    • 40349116206 scopus 로고    scopus 로고
    • Fra-1 regulates vimentin during Ha-RAS-induced epithelial mesenchymal transition in human colon carcinoma cells
    • Andreolas C, Kalogeropoulou M, Voulgari A, Pintzas A. Fra-1 regulates vimentin during Ha-RAS-induced epithelial mesenchymal transition in human colon carcinoma cells. Int J Cancer 2008; 122:1745-56.
    • (2008) Int J Cancer , vol.122 , pp. 1745-1756
    • Andreolas, C.1    Kalogeropoulou, M.2    Voulgari, A.3    Pintzas, A.4
  • 138
    • 0344171934 scopus 로고    scopus 로고
    • The Wnt/Wg signal transducer β-catenin controls fibronectin expression
    • Gradl D, Kuhl M, Wedlich D. The Wnt/Wg signal transducer beta-catenin controls fibronectin expression. Mol Cell Biol 1999; 19:5576-87. (Pubitemid 29339915)
    • (1999) Molecular and Cellular Biology , vol.19 , Issue.8 , pp. 5576-5587
    • Gradl, D.1    Kuhl, M.2    Wedlich, D.3
  • 140
    • 33947217823 scopus 로고    scopus 로고
    • Interaction between beta-catenin and HIF-1 promotes cellular adaptation to hypoxia
    • Kaidi A, Williams AC, Paraskeva C. Interaction between beta-catenin and HIF-1 promotes cellular adaptation to hypoxia. Nat Cell Biol 2007; 9:210-7.
    • (2007) Nat Cell Biol , vol.9 , pp. 210-217
    • Kaidi, A.1    Williams, A.C.2    Paraskeva, C.3
  • 142
    • 50649103964 scopus 로고    scopus 로고
    • Snail promotes Wnt target gene expression and interacts with beta-catenin
    • Stemmer V, de Craene B, Berx G, Behrens J. Snail promotes Wnt target gene expression and interacts with beta-catenin. Oncogene 2008; 27:5075-80.
    • (2008) Oncogene , vol.27 , pp. 5075-5080
    • Stemmer, V.1    De Craene, B.2    Berx, G.3    Behrens, J.4
  • 144
    • 0035991607 scopus 로고    scopus 로고
    • Direct evidence for a role of beta-catenin/LEF-1 signaling pathway in induction of EMT
    • Kim K, Lu Z, Hay ED. Direct evidence for a role of beta-catenin/LEF-1 signaling pathway in induction of EMT. Cell Biol Int 2002; 26:463-76.
    • (2002) Cell Biol Int , vol.26 , pp. 463-476
    • Kim, K.1    Lu, Z.2    Hay, E.D.3
  • 145
    • 4344612243 scopus 로고    scopus 로고
    • NFkappaB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression
    • Huber MA, Azoitei N, Baumann B, Grunert S, Sommer A, Pehamberger H, et al. NFkappaB is essential for epithelial-mesenchymal transition and metastasis in a model of breast cancer progression. J Clin Invest 2004; 114:569-81.
    • (2004) J Clin Invest , vol.114 , pp. 569-581
    • Huber, M.A.1    Azoitei, N.2    Baumann, B.3    Grunert, S.4    Sommer, A.5    Pehamberger, H.6
  • 146
    • 36349011403 scopus 로고    scopus 로고
    • Activation of NFkappaB by Akt upregulates Snail expression and induces epithelium mesenchyme transition
    • Julien S, Puig I, Caretti E, Bonaventure J, Nelles L, van Roy F, et al. Activation of NFkappaB by Akt upregulates Snail expression and induces epithelium mesenchyme transition. Oncogene 2007; 26:7445-56.
    • (2007) Oncogene , vol.26 , pp. 7445-7456
    • Julien, S.1    Puig, I.2    Caretti, E.3    Bonaventure, J.4    Nelles, L.5    Van Roy, F.6
  • 147
    • 4444246328 scopus 로고    scopus 로고
    • Functional role of MIA in melanocytes and early development of melanoma
    • Poser I, Tatzel J, Kuphal S, Bosserhoff AK. Functional role of MIA in melanocytes and early development of melanoma. Oncogene 2004; 23:6115-24.
    • (2004) Oncogene , vol.23 , pp. 6115-6124
    • Poser, I.1    Tatzel, J.2    Kuphal, S.3    Bosserhoff, A.K.4
  • 148
    • 33847736187 scopus 로고    scopus 로고
    • Sp1 is required for transforming growth factor-beta-induced mesenchymal transition and migration in pancreatic cancer cells
    • Jungert K, Buck A, von Wichert G, Adler G, Konig A, Buchholz M, et al. Sp1 is required for transforming growth factor-beta-induced mesenchymal transition and migration in pancreatic cancer cells. Cancer Res 2007; 67:1563-70.
    • (2007) Cancer Res , vol.67 , pp. 1563-1570
    • Jungert, K.1    Buck, A.2    Von Wichert, G.3    Adler, G.4    Konig, A.5    Buchholz, M.6
  • 149
    • 24344483881 scopus 로고    scopus 로고
    • Upregulation of MMP-9 in MDCK epithelial cell line in response to expression of the Snail transcription factor
    • Jorda M, Olmeda D, Vinyals A, Valero E, Cubillo E, Llorens A, et al. Upregulation of MMP-9 in MDCK epithelial cell line in response to expression of the Snail transcription factor. J Cell Sci 2005; 118:3371-85.
    • (2005) J Cell Sci , vol.118 , pp. 3371-3385
    • Jorda, M.1    Olmeda, D.2    Vinyals, A.3    Valero, E.4    Cubillo, E.5    Llorens, A.6
  • 150
    • 0033575194 scopus 로고    scopus 로고
    • SIP1, a novel zinc finger/ homeodomain repressor, interacts with Smad proteins and binds to 5'-CACCT sequences in candidate target genes
    • Verschueren K, Remacle JE, Collart C, Kraft H, Baker BS, Tylzanowski P, et al. SIP1, a novel zinc finger/ homeodomain repressor, interacts with Smad proteins and binds to 5'-CACCT sequences in candidate target genes. J Biol Chem 1999; 274:20489-98.
    • (1999) J Biol Chem , vol.274 , pp. 20489-20498
    • Verschueren, K.1    Remacle, J.E.2    Collart, C.3    Kraft, H.4    Baker, B.S.5    Tylzanowski, P.6
  • 151
    • 35548974844 scopus 로고    scopus 로고
    • The transcription factor ZEB1 (deltaEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity
    • Aigner K, Dampier B, Descovich L, Mikula M, Sultan A, Schreiber M, et al. The transcription factor ZEB1 (deltaEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity. Oncogene 2007; 26:6979-88.
    • (2007) Oncogene , vol.26 , pp. 6979-6988
    • Aigner, K.1    Dampier, B.2    Descovich, L.3    Mikula, M.4    Sultan, A.5    Schreiber, M.6
  • 152
  • 153
    • 60849098434 scopus 로고    scopus 로고
    • Integrin alpha3beta1-dependent beta-catenin phosphorylation links epithelial Smad signaling to cell contacts
    • Kim Y, Kugler MC, Wei Y, Kim KK, Li X, Brumwell AN, et al. Integrin alpha3beta1-dependent beta-catenin phosphorylation links epithelial Smad signaling to cell contacts. J Cell Biol 2009; 184:309-22.
    • (2009) J Cell Biol , vol.184 , pp. 309-322
    • Kim, Y.1    Kugler, M.C.2    Wei, Y.3    Kim, K.K.4    Li, X.5    Brumwell, A.N.6
  • 154
    • 61749102618 scopus 로고    scopus 로고
    • Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis
    • Kim KK, Wei Y, Szekeres C, Kugler MC, Wolters PJ, Hill ML, et al. Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis. J Clin Invest 2009; 119:213-24.
    • (2009) J Clin Invest , vol.119 , pp. 213-224
    • Kim, K.K.1    Wei, Y.2    Szekeres, C.3    Kugler, M.C.4    Wolters, P.J.5    Hill, M.L.6
  • 155
    • 77950553992 scopus 로고    scopus 로고
    • Smad3 prevents beta-catenin degradation and facilitates beta-catenin nuclear translocation in chondrocytes
    • Zhang M, Wang M, Tang X, Li TF, Zhang Y, Chen D. Smad3 prevents beta-catenin degradation and facilitates beta-catenin nuclear translocation in chondrocytes. J Biol Chem 2010.
    • (2010) J Biol Chem
    • Zhang, M.1    Wang, M.2    Tang, X.3    Li, T.F.4    Zhang, Y.5    Chen, D.6
  • 156
    • 47249108568 scopus 로고    scopus 로고
    • Functional blockade of Smad4 leads to a decrease in beta-catenin levels and signaling activity in human pancreatic carcinoma cells
    • Romero D, Iglesias M, Vary CP, Quintanilla M. Functional blockade of Smad4 leads to a decrease in beta-catenin levels and signaling activity in human pancreatic carcinoma cells. Carcinogenesis 2008; 29:1070-6.
    • (2008) Carcinogenesis , vol.29 , pp. 1070-1076
    • Romero, D.1    Iglesias, M.2    Vary, C.P.3    Quintanilla, M.4
  • 157
    • 0034682515 scopus 로고    scopus 로고
    • Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways
    • Labbe E, Letamendia A, Attisano L. Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways. Proc Natl Acad Sci USA 2000; 97:8358-63.
    • Proc Natl Acad Sci USA 2000 , vol.97 , pp. 8358-8363
    • Labbe, E.1    Letamendia, A.2    Attisano, L.3
  • 158
    • 0034677494 scopus 로고    scopus 로고
    • Interaction between Wnt and TGFbeta signalling pathways during formation of Spemann's organizer
    • Nishita M, Hashimoto MK, Ogata S, Laurent MN, Ueno N, Shibuya H, et al. Interaction between Wnt and TGFbeta signalling pathways during formation of Spemann's organizer. Nature 2000; 403:781-5.
    • (2000) Nature , vol.403 , pp. 781-785
    • Nishita, M.1    Hashimoto, M.K.2    Ogata, S.3    Laurent, M.N.4    Ueno, N.5    Shibuya, H.6
  • 159
    • 34249674558 scopus 로고    scopus 로고
    • TGFbeta3 inhibits E-cadherin gene expression in palate medialedge epithelial cells through a Smad2-Smad4-LEF1 transcription complex
    • Nawshad A, Medici D, Liu CC, Hay ED. TGFbeta3 inhibits E-cadherin gene expression in palate medialedge epithelial cells through a Smad2-Smad4-LEF1 transcription complex. J Cell Sci 2007; 120:1646-53.
    • (2007) J Cell Sci , vol.120 , pp. 1646-1653
    • Nawshad, A.1    Medici, D.2    Liu, C.C.3    Hay, E.D.4
  • 160
    • 33847039608 scopus 로고    scopus 로고
    • TGFbeta1 regulation of vimentin gene expression during differentiation of the C2C12 skeletal myogenic cell line requires Smads, AP-1 and Sp1 family members
    • Wu Y, Zhang X, Salmon M, Lin X, Zehner ZE. TGFbeta1 regulation of vimentin gene expression during differentiation of the C2C12 skeletal myogenic cell line requires Smads, AP-1 and Sp1 family members. Biochimica et biophysica acta 2007; 1773:427-39.
    • (2007) Biochimica et Biophysica Acta , vol.1773 , pp. 427-439
    • Wu, Y.1    Zhang, X.2    Salmon, M.3    Lin, X.4    Zehner, Z.E.5
  • 161
    • 0035821745 scopus 로고    scopus 로고
    • Smad3/AP-1 interactions control transcriptional responses to TGFbeta in a promoter-specific manner
    • Verrecchia F, Vindevoghel L, Lechleider RJ, Uitto J, Roberts AB, Mauviel A. Smad3/AP-1 interactions control transcriptional responses to TGFbeta in a promoter-specific manner. Oncogene 2001; 20:3332-40.
    • (2001) Oncogene , vol.20 , pp. 3332-3340
    • Verrecchia, F.1    Vindevoghel, L.2    Lechleider, R.J.3    Uitto, J.4    Roberts, A.B.5    Mauviel, A.6
  • 162
    • 0034704076 scopus 로고    scopus 로고
    • Regulation of plasminogen activator inhibitor-1 expression by transforming growth factor-beta-induced physical and functional interactions between smads and Sp1
    • Datta PK, Blake MC, Moses HL. Regulation of plasminogen activator inhibitor-1 expression by transforming growth factor-beta-induced physical and functional interactions between smads and Sp1. J Biol Chem 2000; 275:40014-9.
    • (2000) J Biol Chem , vol.275 , pp. 40014-40019
    • Datta, P.K.1    Blake, M.C.2    Moses, H.L.3
  • 163
    • 44649131934 scopus 로고    scopus 로고
    • The plasminogen activator inhibitor "paradox" in cancer
    • Binder BR, Mihaly J. The plasminogen activator inhibitor "paradox" in cancer. Immunol Lett 2008; 118:116-24.
    • (2008) Immunol Lett , vol.118 , pp. 116-124
    • Binder, B.R.1    Mihaly, J.2
  • 164
    • 38949143636 scopus 로고    scopus 로고
    • Cancer invasion and metastasis: Changing views
    • Duffy MJ, McGowan PM, Gallagher WM. Cancer invasion and metastasis: changing views. J Pathol 2008; 214:283-93.
    • (2008) J Pathol , vol.214 , pp. 283-293
    • Duffy, M.J.1    McGowan, P.M.2    Gallagher, W.M.3
  • 165
    • 34247251943 scopus 로고    scopus 로고
    • PAI-1 is a Critical Upstream Regulator of the TGFbeta1/EGF-Induced Invasive Phenotype in Mutant p53 Human Cutaneous Squamous Cell Carcinoma
    • Wilkins-Port CE, Higgins CE, Freytag J, Higgins SP, Carlson JA, Higgins PJ. PAI-1 is a Critical Upstream Regulator of the TGFbeta1/EGF-Induced Invasive Phenotype in Mutant p53 Human Cutaneous Squamous Cell Carcinoma. J Biomed Biotechnol 2007; 2007:85208.
    • (2007) J Biomed Biotechnol , vol.2007 , pp. 85208
    • Wilkins-Port, C.E.1    Higgins, C.E.2    Freytag, J.3    Higgins, S.P.4    Carlson, J.A.5    Higgins, P.J.6
  • 167
    • 0035860680 scopus 로고    scopus 로고
    • Identification of a critical Sp1 site within the endoglin promoter and its involvement in the transforming growth factor-beta stimulation
    • Botella LM, Sanchez-Elsner T, Rius C, Corbi A, Bernabeu C. Identification of a critical Sp1 site within the endoglin promoter and its involvement in the transforming growth factor-beta stimulation. J Biol Chem 2001; 276:34486-94.
    • (2001) J Biol Chem , vol.276 , pp. 34486-34494
    • Botella, L.M.1    Sanchez-Elsner, T.2    Rius, C.3    Corbi, A.4    Bernabeu, C.5
  • 168
    • 0035831503 scopus 로고    scopus 로고
    • Sp1 and Smad proteins cooperate to mediate transforming growth factor-beta 1-induced alpha 2(I) collagen expression in human glomerular mesangial cells
    • Poncelet AC, Schnaper HW. Sp1 and Smad proteins cooperate to mediate transforming growth factor-beta 1-induced alpha 2(I) collagen expression in human glomerular mesangial cells. J Biol Chem 2001; 276:6983-92.
    • (2001) J Biol Chem , vol.276 , pp. 6983-6992
    • Poncelet, A.C.1    Schnaper, H.W.2
  • 169
    • 0346363875 scopus 로고    scopus 로고
    • Transcriptional control of the mouse Col7a1 gene in keratinocytes: Basal and transforming growth factor-beta regulated expression
    • Naso M, Uitto J, Klement JF. Transcriptional control of the mouse Col7a1 gene in keratinocytes: basal and transforming growth factor-beta regulated expression. J Invest Dermatol 2003; 121:1469-78.
    • (2003) J Invest Dermatol , vol.121 , pp. 1469-1478
    • Naso, M.1    Uitto, J.2    Klement, J.F.3
  • 171
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation and cancer
    • Coussens LM, Werb Z. Inflammation and cancer. Nature 2002; 420:860-7.
    • (2002) Nature , vol.420 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 172
    • 70350238658 scopus 로고    scopus 로고
    • Inflammation: A driving force speeds cancer metastasis
    • Wu Y, Zhou BP. Inflammation: a driving force speeds cancer metastasis. Cell Cycle 2009; 8:3267-73.
    • (2009) Cell Cycle , vol.8 , pp. 3267-3273
    • Wu, Y.1    Zhou, B.P.2
  • 173
    • 70450142560 scopus 로고    scopus 로고
    • Inflammation and EMT: An alliance towards organ fibrosis and cancer progression
    • Lopez-Novoa JM, Nieto MA. Inflammation and EMT: an alliance towards organ fibrosis and cancer progression. EMBO Mol Med 2009; 1:303-14.
    • (2009) EMBO Mol Med , vol.1 , pp. 303-314
    • Lopez-Novoa, J.M.1    Nieto, M.A.2
  • 174
    • 47049116663 scopus 로고    scopus 로고
    • Activated macrophages promote Wnt signalling through tumour necrosis factor-alpha in gastric tumour cells
    • Oguma K, Oshima H, Aoki M, Uchio R, Naka K, Nakamura S, et al. Activated macrophages promote Wnt signalling through tumour necrosis factor-alpha in gastric tumour cells. EMBO J 2008; 27:1671-81.
    • (2008) EMBO J , vol.27 , pp. 1671-1681
    • Oguma, K.1    Oshima, H.2    Aoki, M.3    Uchio, R.4    Naka, K.5    Nakamura, S.6
  • 176
    • 17244376814 scopus 로고    scopus 로고
    • Wnt signalling in stem cells and cancer
    • Reya T, Clevers H. Wnt signalling in stem cells and cancer. Nature 2005; 434:843-50.
    • (2005) Nature , vol.434 , pp. 843-850
    • Reya, T.1    Clevers, H.2
  • 177
    • 60449117235 scopus 로고    scopus 로고
    • Identification of invasion specific splice variants of the cytoskeletal protein Mena present in mammary tumor cells during invasion in vivo
    • Goswami S, Philippar U, Sun D, Patsialou A, Avraham J, Wang W, et al. Identification of invasion specific splice variants of the cytoskeletal protein Mena present in mammary tumor cells during invasion in vivo. Clin Exp Metastasis 2009; 26:153-9.
    • (2009) Clin Exp Metastasis , vol.26 , pp. 153-159
    • Goswami, S.1    Philippar, U.2    Sun, D.3    Patsialou, A.4    Avraham, J.5    Wang, W.6
  • 178
    • 57049125131 scopus 로고    scopus 로고
    • A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis
    • Philippar U, Roussos ET, Oser M, Yamaguchi H, Kim HD, Giampieri S, et al. A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis. Dev Cell 2008; 15:813-28.
    • (2008) Dev Cell , vol.15 , pp. 813-828
    • Philippar, U.1    Roussos, E.T.2    Oser, M.3    Yamaguchi, H.4    Kim, H.D.5    Giampieri, S.6
  • 179
    • 34249281332 scopus 로고    scopus 로고
    • The cofilin pathway in breast cancer invasion and metastasis
    • Wang W, Eddy R, Condeelis J. The cofilin pathway in breast cancer invasion and metastasis. Nat Rev Cancer 2007; 7:429-40.
    • (2007) Nat Rev Cancer , vol.7 , pp. 429-440
    • Wang, W.1    Eddy, R.2    Condeelis, J.3
  • 181
    • 33845209913 scopus 로고    scopus 로고
    • A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes
    • Neve RM, Chin K, Fridlyand J, Yeh J, Baehner FL, Fevr T, et al. A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell 2006; 10:515-27.
    • (2006) Cancer Cell , vol.10 , pp. 515-527
    • Neve, R.M.1    Chin, K.2    Fridlyand, J.3    Yeh, J.4    Baehner, F.L.5    Fevr, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.