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Volumn 10, Issue 15, 2011, Pages 2450-2453

From growing to secreting: New roles for mTOR in aging cells

Author keywords

Aging; Autophagy; Cell senescence; Cytokines; mTOR; Nutrient signaling; Secretory phenotype; Stem cells

Indexed keywords

GROWTH FACTOR; MAMMALIAN TARGET OF RAPAMYCIN;

EID: 79961099905     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.10.15.16886     Document Type: Review
Times cited : (38)

References (29)
  • 1
    • 78650510609 scopus 로고    scopus 로고
    • mTOR: From growth signal integration to cancer, diabetes and ageing
    • PMID: 21157483; DOI: 10.1038/nrm3025
    • Zoncu R, Efeyan A, Sabatini DM mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 2011; 12:21-35; PMID: 21157483; DOI: 10.1038/nrm3025.
    • (2011) Nat Rev Mol Cell Biol , vol.12 , pp. 21-35
    • Zoncu, R.1    Efeyan, A.2    Sabatini, D.M.3
  • 2
    • 67650944993 scopus 로고    scopus 로고
    • Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
    • PMID: 19587680
    • Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 2009; 460:392-5; PMID: 19587680.
    • (2009) Nature , vol.460 , pp. 392-395
    • Harrison, D.E.1    Strong, R.2    Sharp, Z.D.3    Nelson, J.F.4    Astle, C.M.5    Flurkey, K.6
  • 3
    • 70349669095 scopus 로고    scopus 로고
    • Ribosomal protein S6 kinase 1 signaling regulates mammalian life span
    • PMID: 19797661; DOI: 10.1126/science.1177221
    • Selman C, Tullet JM, Wieser D, Irvine E, Lingard SJ, Choudhury AI, et al. Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science 2009; 326:140-4; PMID: 19797661; DOI: 10.1126/science.1177221.
    • (2009) Science , vol.326 , pp. 140-144
    • Selman, C.1    Tullet, J.M.2    Wieser, D.3    Irvine, E.4    Lingard, S.J.5    Choudhury, A.I.6
  • 5
    • 0642367846 scopus 로고    scopus 로고
    • Genetics: Influence of TOR kinase on lifespan in C. elegans
    • PMID: 14668850; DOI: 10.1038/426620a
    • Vellai T, Takacs-Vellai K, Zhang Y, Kovacs AL, Orosz L, Muller F. Genetics: influence of TOR kinase on lifespan in C. elegans. Nature 2003; 426:620; PMID: 14668850; DOI: 10.1038/426620a.
    • (2003) Nature , vol.426 , pp. 620
    • Vellai, T.1    Takacs-Vellai, K.2    Zhang, Y.3    Kovacs, A.L.4    Orosz, L.5    Muller, F.6
  • 6
    • 55849152355 scopus 로고    scopus 로고
    • Aging: ROS or TOR
    • PMID: 18971624; DOI: 10.4161/cc.7.21.6965
    • Blagosklonny MV. Aging: ROS or TOR. Cell Cycle 2008; 7:3344-54; PMID: 18971624; DOI: 10.4161/cc.7.21.6965.
    • (2008) Cell Cycle , vol.7 , pp. 3344-3354
    • Blagosklonny, M.V.1
  • 7
    • 77953645579 scopus 로고    scopus 로고
    • Rapamycin and quasi-programmed aging: Four years later
    • PMID: 20436272; DOI: 10.4161/cc.9.10.11872
    • Blagosklonny MV. Rapamycin and quasi-programmed aging: four years later. Cell Cycle 2010; 9:1859-62; PMID: 20436272; DOI: 10.4161/cc.9.10.11872.
    • (2010) Cell Cycle , vol.9 , pp. 1859-1862
    • Blagosklonny, M.V.1
  • 8
    • 70349266064 scopus 로고    scopus 로고
    • Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging
    • PMID: 19706382; DOI: 10.1073/pnas.0902882106
    • Ben-Zvi A, Miller EA, Morimoto RI. Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging. Proc Natl Acad Sci USA 2009; 106:14914-9; PMID: 19706382; DOI: 10.1073/pnas.0902882106.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 14914-14919
    • Ben-Zvi, A.1    Miller, E.A.2    Morimoto, R.I.3
  • 9
    • 2642586352 scopus 로고    scopus 로고
    • Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
    • PMID: 15146184; DOI: 10.1038/ng1362
    • Ravikumar B, Vacher C, Berger Z, Davies JE, Luo S, Oroz LG, et al. Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat Genet 2004; 36:585-95; PMID: 15146184; DOI: 10.1038/ng1362.
    • (2004) Nat Genet , vol.36 , pp. 585-595
    • Ravikumar, B.1    Vacher, C.2    Berger, Z.3    Davies, J.E.4    Luo, S.5    Oroz, L.G.6
  • 10
    • 4544220704 scopus 로고    scopus 로고
    • Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
    • PMID: 15306821; DOI: 10.1038/nature02866
    • Um SH, Frigerio F, Watanabe M, Picard F, Joaquin M, Sticker M, et al. Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature 2004; 431:200-5; PMID: 15306821; DOI: 10.1038/nature02866.
    • (2004) Nature , vol.431 , pp. 200-205
    • Um, S.H.1    Frigerio, F.2    Watanabe, M.3    Picard, F.4    Joaquin, M.5    Sticker, M.6
  • 11
    • 67649347537 scopus 로고    scopus 로고
    • Growth and aging: A common molecular mechanism
    • (Albany NY) PMID: 20157523
    • Blagosklonny MV, Hall MN. Growth and aging: a common molecular mechanism. Aging (Albany NY) 2009; 1:357-62; PMID: 20157523.
    • (2009) Aging , vol.1 , pp. 357-362
    • Blagosklonny, M.V.1    Hall, M.N.2
  • 12
    • 79951912532 scopus 로고    scopus 로고
    • Four faces of cellular senescence
    • PMID: 21321098; DOI: 10.1083/jcb.201009094
    • Rodier F, Campisi J. Four faces of cellular senescence. J Cell Biol 2011; 192:547-56; PMID: 21321098; DOI: 10.1083/jcb.201009094.
    • (2011) J Cell Biol , vol.192 , pp. 547-556
    • Rodier, F.1    Campisi, J.2
  • 13
    • 67649318940 scopus 로고    scopus 로고
    • MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8
    • (Albany NY) PMID: 20148189
    • Bhaumik D, Scott GK, Schokrpur S, Patil CK, Orjalo AV, Rodier F, et al. MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8. Aging (Albany NY) 2009; 1:402-11; PMID: 20148189.
    • (2009) Aging , vol.1 , pp. 402-411
    • Bhaumik, D.1    Scott, G.K.2    Schokrpur, S.3    Patil, C.K.4    Orjalo, A.V.5    Rodier, F.6
  • 14
    • 68249096784 scopus 로고    scopus 로고
    • Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
    • PMID: 19597488; DOI: 10.1038/ncb1909
    • Rodier F, Coppe JP, Patil CK, Hoeijmakers WA, Munoz DP, Raza SR, et al. Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. Nat Cell Biol 2009; 11:973-9; PMID: 19597488; DOI: 10.1038/ncb1909.
    • (2009) Nat Cell Biol , vol.11 , pp. 973-979
    • Rodier, F.1    Coppe, J.P.2    Patil, C.K.3    Hoeijmakers, W.A.4    Munoz, D.P.5    Raza, S.R.6
  • 15
    • 79955017452 scopus 로고    scopus 로고
    • MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype
    • PMID: 21399611; DOI: 10.1038/emboj.2011.69
    • MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype. EMBO J 2011; 30:1536-48; PMID: 21399611; DOI: 10.1038/emboj.2011.69.
    • (2011) EMBO J , vol.30 , pp. 1536-1548
    • Freund, A.1    Patil, C.K.2    Campisi, J.3
  • 16
    • 13944260728 scopus 로고    scopus 로고
    • Stromal-epithelial interactions in aging and cancer: Senescent fibroblasts alter epithelial cell differentiation
    • PMID: 15657080; DOI: 10.1242/jcs.01635
    • Parrinello S, Coppe JP, Krtolica A, Campisi J. Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation. J Cell Sci 2005; 118:485-96; PMID: 15657080; DOI: 10.1242/jcs.01635.
    • (2005) J Cell Sci , vol.118 , pp. 485-496
    • Parrinello, S.1    Coppe, J.P.2    Krtolica, A.3    Campisi, J.4
  • 18
    • 77953111224 scopus 로고    scopus 로고
    • Quantifying pharmacologic suppression of cellular senescence: Prevention of cellular hypertrophy versus preservation of proliferative potential
    • (Albany NY) PMID: 20157583
    • Demidenko ZN, Blagosklonny MV. Quantifying pharmacologic suppression of cellular senescence: prevention of cellular hypertrophy versus preservation of proliferative potential. Aging (Albany NY) 2009; 1:1008-16; PMID: 20157583.
    • (2009) Aging , vol.1 , pp. 1008-1016
    • Demidenko, Z.N.1    Blagosklonny, M.V.2
  • 19
    • 50549087736 scopus 로고    scopus 로고
    • Growth stimulation leads to cellular senescence when the cell cycle is blocked
    • PMID: 18948731; DOI: 10.4161/cc.7.21.6919
    • Demidenko ZN, Blagosklonny MV. Growth stimulation leads to cellular senescence when the cell cycle is blocked. Cell Cycle 2008; 7:3355-61; PMID: 18948731; DOI: 10.4161/cc.7.21.6919.
    • (2008) Cell Cycle , vol.7 , pp. 3355-3361
    • Demidenko, Z.N.1    Blagosklonny, M.V.2
  • 20
    • 78650804447 scopus 로고    scopus 로고
    • Nutrient withdrawal rescues growth factor-deprived cells from mTOR-dependent damage
    • (Albany NY) PMID: 20739737
    • Panieri E, Toietta G, Mele M, Labate V, Ranieri SC, Fusco S, et al. Nutrient withdrawal rescues growth factor-deprived cells from mTOR-dependent damage. Aging (Albany NY) 2010; 2:487-503; PMID: 20739737.
    • (2010) Aging , vol.2 , pp. 487-503
    • Panieri, E.1    Toietta, G.2    Mele, M.3    Labate, V.4    Ranieri, S.C.5    Fusco, S.6
  • 21
    • 79956325949 scopus 로고    scopus 로고
    • Spatial coupling of mTOR and autophagy augments secretory phenotypes
    • PMID: 21512002; DOI: 10.1126/science.1205407
    • Narita M, Young AR, Arakawa S, Samarajiwa SA, Nakashima T, Yoshida S, et al. Spatial coupling of mTOR and autophagy augments secretory phenotypes. Science 2011; 332:966-70; PMID: 21512002; DOI: 10.1126/science.1205407.
    • (2011) Science , vol.332 , pp. 966-970
    • Narita, M.1    Young, A.R.2    Arakawa, S.3    Samarajiwa, S.A.4    Nakashima, T.5    Yoshida, S.6
  • 22
    • 79551598347 scopus 로고    scopus 로고
    • AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
    • PMID: 21258367; DOI: 10.1038/ncb2152
    • Kim J, Kundu M, Viollet B, Guan KL. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol 2011; 13:132-41; PMID: 21258367; DOI: 10.1038/ncb2152.
    • (2011) Nat Cell Biol , vol.13 , pp. 132-141
    • Kim, J.1    Kundu, M.2    Viollet, B.3    Guan, K.L.4
  • 23
    • 13944270339 scopus 로고    scopus 로고
    • Senescent cells, tumor suppression and organismal aging: Good citizens, bad neighbors
    • PMID: 15734683; DOI: 10.1016/j.cell.2005.02.003
    • Campisi J. Senescent cells, tumor suppression and organismal aging: good citizens, bad neighbors. Cell 2005; 120:513-22; PMID: 15734683; DOI: 10.1016/j.cell.2005.02.003.
    • (2005) Cell , vol.120 , pp. 513-522
    • Campisi, J.1
  • 24
    • 13944261231 scopus 로고    scopus 로고
    • Rejuvenation of aged progenitor cells by exposure to a young systemic environment
    • PMID: 15716955; DOI: 10.1038/nature03260
    • Conboy IM, Conboy MJ, Wagers AJ, Girma ER, Weissman IL, Rando TA. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature 2005; 433:760-4; PMID: 15716955; DOI: 10.1038/nature03260.
    • (2005) Nature , vol.433 , pp. 760-764
    • Conboy, I.M.1    Conboy, M.J.2    Wagers, A.J.3    Girma, E.R.4    Weissman, I.L.5    Rando, T.A.6
  • 25
    • 33745614062 scopus 로고    scopus 로고
    • Stem cells, ageing and the quest for immortality
    • PMID: 16810243; DOI: 10.1038/nature04958
    • Rando TA. Stem cells, ageing and the quest for immortality. Nature 2006; 441:1080-6; PMID: 16810243; DOI: 10.1038/nature04958.
    • (2006) Nature , vol.441 , pp. 1080-1086
    • Rando, T.A.1
  • 27
    • 77955722198 scopus 로고    scopus 로고
    • Revisiting the antagonistic pleiotropy theory of aging: TOR-driven program and quasi-program
    • PMID: 20724817; DOI: 10.4161/cc.9.16.13120
    • Blagosklonny MV. Revisiting the antagonistic pleiotropy theory of aging: TOR-driven program and quasi-program. Cell Cycle 2010; 9:3151-6; PMID: 20724817; DOI: 10.4161/cc.9.16.13120.
    • (2010) Cell Cycle , vol.9 , pp. 3151-3156
    • Blagosklonny, M.V.1
  • 28
    • 35948982621 scopus 로고    scopus 로고
    • The role of autophagy in aging: Its essential part in the anti-aging mechanism of caloric restriction
    • DOI: 10.1196/annals.1396.020
    • Bergamini E, Cavallini G, Donati A, Gori Z. The role of autophagy in aging: its essential part in the anti-aging mechanism of caloric restriction. Ann NY Acad Sci 2007; 1114:69-78; DOI: 10.1196/annals.1396.020.
    • (2007) Ann NY Acad Sci , vol.1114 , pp. 69-78
    • Bergamini, E.1    Cavallini, G.2    Donati, A.3    Gori, Z.4
  • 29
    • 47949099098 scopus 로고    scopus 로고
    • Origin and physiological roles of inflammation
    • PMID: 18650913; DOI: 10.1038/nature07201
    • Medzhitov R. Origin and physiological roles of inflammation. Nature 2008; 454:428-35; PMID: 18650913; DOI: 10.1038/nature07201.
    • (2008) Nature , vol.454 , pp. 428-435
    • Medzhitov, R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.