-
1
-
-
78650510609
-
mTOR: From growth signal integration to cancer, diabetes and ageing
-
PMID: 21157483; DOI: 10.1038/nrm3025
-
Zoncu R, Efeyan A, Sabatini DM mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 2011; 12:21-35; PMID: 21157483; DOI: 10.1038/nrm3025.
-
(2011)
Nat Rev Mol Cell Biol
, vol.12
, pp. 21-35
-
-
Zoncu, R.1
Efeyan, A.2
Sabatini, D.M.3
-
2
-
-
67650944993
-
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
-
PMID: 19587680
-
Harrison DE, Strong R, Sharp ZD, Nelson JF, Astle CM, Flurkey K, et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 2009; 460:392-5; PMID: 19587680.
-
(2009)
Nature
, vol.460
, pp. 392-395
-
-
Harrison, D.E.1
Strong, R.2
Sharp, Z.D.3
Nelson, J.F.4
Astle, C.M.5
Flurkey, K.6
-
3
-
-
70349669095
-
Ribosomal protein S6 kinase 1 signaling regulates mammalian life span
-
PMID: 19797661; DOI: 10.1126/science.1177221
-
Selman C, Tullet JM, Wieser D, Irvine E, Lingard SJ, Choudhury AI, et al. Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science 2009; 326:140-4; PMID: 19797661; DOI: 10.1126/science.1177221.
-
(2009)
Science
, vol.326
, pp. 140-144
-
-
Selman, C.1
Tullet, J.M.2
Wieser, D.3
Irvine, E.4
Lingard, S.J.5
Choudhury, A.I.6
-
5
-
-
0642367846
-
Genetics: Influence of TOR kinase on lifespan in C. elegans
-
PMID: 14668850; DOI: 10.1038/426620a
-
Vellai T, Takacs-Vellai K, Zhang Y, Kovacs AL, Orosz L, Muller F. Genetics: influence of TOR kinase on lifespan in C. elegans. Nature 2003; 426:620; PMID: 14668850; DOI: 10.1038/426620a.
-
(2003)
Nature
, vol.426
, pp. 620
-
-
Vellai, T.1
Takacs-Vellai, K.2
Zhang, Y.3
Kovacs, A.L.4
Orosz, L.5
Muller, F.6
-
6
-
-
55849152355
-
Aging: ROS or TOR
-
PMID: 18971624; DOI: 10.4161/cc.7.21.6965
-
Blagosklonny MV. Aging: ROS or TOR. Cell Cycle 2008; 7:3344-54; PMID: 18971624; DOI: 10.4161/cc.7.21.6965.
-
(2008)
Cell Cycle
, vol.7
, pp. 3344-3354
-
-
Blagosklonny, M.V.1
-
7
-
-
77953645579
-
Rapamycin and quasi-programmed aging: Four years later
-
PMID: 20436272; DOI: 10.4161/cc.9.10.11872
-
Blagosklonny MV. Rapamycin and quasi-programmed aging: four years later. Cell Cycle 2010; 9:1859-62; PMID: 20436272; DOI: 10.4161/cc.9.10.11872.
-
(2010)
Cell Cycle
, vol.9
, pp. 1859-1862
-
-
Blagosklonny, M.V.1
-
8
-
-
70349266064
-
Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging
-
PMID: 19706382; DOI: 10.1073/pnas.0902882106
-
Ben-Zvi A, Miller EA, Morimoto RI. Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging. Proc Natl Acad Sci USA 2009; 106:14914-9; PMID: 19706382; DOI: 10.1073/pnas.0902882106.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 14914-14919
-
-
Ben-Zvi, A.1
Miller, E.A.2
Morimoto, R.I.3
-
9
-
-
2642586352
-
Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease
-
PMID: 15146184; DOI: 10.1038/ng1362
-
Ravikumar B, Vacher C, Berger Z, Davies JE, Luo S, Oroz LG, et al. Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease. Nat Genet 2004; 36:585-95; PMID: 15146184; DOI: 10.1038/ng1362.
-
(2004)
Nat Genet
, vol.36
, pp. 585-595
-
-
Ravikumar, B.1
Vacher, C.2
Berger, Z.3
Davies, J.E.4
Luo, S.5
Oroz, L.G.6
-
10
-
-
4544220704
-
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
-
PMID: 15306821; DOI: 10.1038/nature02866
-
Um SH, Frigerio F, Watanabe M, Picard F, Joaquin M, Sticker M, et al. Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature 2004; 431:200-5; PMID: 15306821; DOI: 10.1038/nature02866.
-
(2004)
Nature
, vol.431
, pp. 200-205
-
-
Um, S.H.1
Frigerio, F.2
Watanabe, M.3
Picard, F.4
Joaquin, M.5
Sticker, M.6
-
11
-
-
67649347537
-
Growth and aging: A common molecular mechanism
-
(Albany NY) PMID: 20157523
-
Blagosklonny MV, Hall MN. Growth and aging: a common molecular mechanism. Aging (Albany NY) 2009; 1:357-62; PMID: 20157523.
-
(2009)
Aging
, vol.1
, pp. 357-362
-
-
Blagosklonny, M.V.1
Hall, M.N.2
-
12
-
-
79951912532
-
Four faces of cellular senescence
-
PMID: 21321098; DOI: 10.1083/jcb.201009094
-
Rodier F, Campisi J. Four faces of cellular senescence. J Cell Biol 2011; 192:547-56; PMID: 21321098; DOI: 10.1083/jcb.201009094.
-
(2011)
J Cell Biol
, vol.192
, pp. 547-556
-
-
Rodier, F.1
Campisi, J.2
-
13
-
-
67649318940
-
MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8
-
(Albany NY) PMID: 20148189
-
Bhaumik D, Scott GK, Schokrpur S, Patil CK, Orjalo AV, Rodier F, et al. MicroRNAs miR-146a/b negatively modulate the senescence-associated inflammatory mediators IL-6 and IL-8. Aging (Albany NY) 2009; 1:402-11; PMID: 20148189.
-
(2009)
Aging
, vol.1
, pp. 402-411
-
-
Bhaumik, D.1
Scott, G.K.2
Schokrpur, S.3
Patil, C.K.4
Orjalo, A.V.5
Rodier, F.6
-
14
-
-
68249096784
-
Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion
-
PMID: 19597488; DOI: 10.1038/ncb1909
-
Rodier F, Coppe JP, Patil CK, Hoeijmakers WA, Munoz DP, Raza SR, et al. Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. Nat Cell Biol 2009; 11:973-9; PMID: 19597488; DOI: 10.1038/ncb1909.
-
(2009)
Nat Cell Biol
, vol.11
, pp. 973-979
-
-
Rodier, F.1
Coppe, J.P.2
Patil, C.K.3
Hoeijmakers, W.A.4
Munoz, D.P.5
Raza, S.R.6
-
15
-
-
79955017452
-
MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype
-
PMID: 21399611; DOI: 10.1038/emboj.2011.69
-
MAPK is a novel DNA damage response-independent regulator of the senescence-associated secretory phenotype. EMBO J 2011; 30:1536-48; PMID: 21399611; DOI: 10.1038/emboj.2011.69.
-
(2011)
EMBO J
, vol.30
, pp. 1536-1548
-
-
Freund, A.1
Patil, C.K.2
Campisi, J.3
-
16
-
-
13944260728
-
Stromal-epithelial interactions in aging and cancer: Senescent fibroblasts alter epithelial cell differentiation
-
PMID: 15657080; DOI: 10.1242/jcs.01635
-
Parrinello S, Coppe JP, Krtolica A, Campisi J. Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation. J Cell Sci 2005; 118:485-96; PMID: 15657080; DOI: 10.1242/jcs.01635.
-
(2005)
J Cell Sci
, vol.118
, pp. 485-496
-
-
Parrinello, S.1
Coppe, J.P.2
Krtolica, A.3
Campisi, J.4
-
17
-
-
67649316033
-
Rapamycin decelerates cellular senescence
-
PMID: 19471117; DOI: 10.4161/cc.8.12.8606
-
Demidenko ZN, Zubova SG, Bukreeva EI, Pospelov VA, Pospelova TV, Blagosklonny MV. Rapamycin decelerates cellular senescence. Cell Cycle 2009; 8:1888-95; PMID: 19471117; DOI: 10.4161/cc.8.12.8606.
-
(2009)
Cell Cycle
, vol.8
, pp. 1888-1895
-
-
Demidenko, Z.N.1
Zubova, S.G.2
Bukreeva, E.I.3
Pospelov, V.A.4
Pospelova, T.V.5
Blagosklonny, M.V.6
-
18
-
-
77953111224
-
Quantifying pharmacologic suppression of cellular senescence: Prevention of cellular hypertrophy versus preservation of proliferative potential
-
(Albany NY) PMID: 20157583
-
Demidenko ZN, Blagosklonny MV. Quantifying pharmacologic suppression of cellular senescence: prevention of cellular hypertrophy versus preservation of proliferative potential. Aging (Albany NY) 2009; 1:1008-16; PMID: 20157583.
-
(2009)
Aging
, vol.1
, pp. 1008-1016
-
-
Demidenko, Z.N.1
Blagosklonny, M.V.2
-
19
-
-
50549087736
-
Growth stimulation leads to cellular senescence when the cell cycle is blocked
-
PMID: 18948731; DOI: 10.4161/cc.7.21.6919
-
Demidenko ZN, Blagosklonny MV. Growth stimulation leads to cellular senescence when the cell cycle is blocked. Cell Cycle 2008; 7:3355-61; PMID: 18948731; DOI: 10.4161/cc.7.21.6919.
-
(2008)
Cell Cycle
, vol.7
, pp. 3355-3361
-
-
Demidenko, Z.N.1
Blagosklonny, M.V.2
-
20
-
-
78650804447
-
Nutrient withdrawal rescues growth factor-deprived cells from mTOR-dependent damage
-
(Albany NY) PMID: 20739737
-
Panieri E, Toietta G, Mele M, Labate V, Ranieri SC, Fusco S, et al. Nutrient withdrawal rescues growth factor-deprived cells from mTOR-dependent damage. Aging (Albany NY) 2010; 2:487-503; PMID: 20739737.
-
(2010)
Aging
, vol.2
, pp. 487-503
-
-
Panieri, E.1
Toietta, G.2
Mele, M.3
Labate, V.4
Ranieri, S.C.5
Fusco, S.6
-
21
-
-
79956325949
-
Spatial coupling of mTOR and autophagy augments secretory phenotypes
-
PMID: 21512002; DOI: 10.1126/science.1205407
-
Narita M, Young AR, Arakawa S, Samarajiwa SA, Nakashima T, Yoshida S, et al. Spatial coupling of mTOR and autophagy augments secretory phenotypes. Science 2011; 332:966-70; PMID: 21512002; DOI: 10.1126/science.1205407.
-
(2011)
Science
, vol.332
, pp. 966-970
-
-
Narita, M.1
Young, A.R.2
Arakawa, S.3
Samarajiwa, S.A.4
Nakashima, T.5
Yoshida, S.6
-
22
-
-
79551598347
-
AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
-
PMID: 21258367; DOI: 10.1038/ncb2152
-
Kim J, Kundu M, Viollet B, Guan KL. AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1. Nat Cell Biol 2011; 13:132-41; PMID: 21258367; DOI: 10.1038/ncb2152.
-
(2011)
Nat Cell Biol
, vol.13
, pp. 132-141
-
-
Kim, J.1
Kundu, M.2
Viollet, B.3
Guan, K.L.4
-
23
-
-
13944270339
-
Senescent cells, tumor suppression and organismal aging: Good citizens, bad neighbors
-
PMID: 15734683; DOI: 10.1016/j.cell.2005.02.003
-
Campisi J. Senescent cells, tumor suppression and organismal aging: good citizens, bad neighbors. Cell 2005; 120:513-22; PMID: 15734683; DOI: 10.1016/j.cell.2005.02.003.
-
(2005)
Cell
, vol.120
, pp. 513-522
-
-
Campisi, J.1
-
24
-
-
13944261231
-
Rejuvenation of aged progenitor cells by exposure to a young systemic environment
-
PMID: 15716955; DOI: 10.1038/nature03260
-
Conboy IM, Conboy MJ, Wagers AJ, Girma ER, Weissman IL, Rando TA. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature 2005; 433:760-4; PMID: 15716955; DOI: 10.1038/nature03260.
-
(2005)
Nature
, vol.433
, pp. 760-764
-
-
Conboy, I.M.1
Conboy, M.J.2
Wagers, A.J.3
Girma, E.R.4
Weissman, I.L.5
Rando, T.A.6
-
25
-
-
33745614062
-
Stem cells, ageing and the quest for immortality
-
PMID: 16810243; DOI: 10.1038/nature04958
-
Rando TA. Stem cells, ageing and the quest for immortality. Nature 2006; 441:1080-6; PMID: 16810243; DOI: 10.1038/nature04958.
-
(2006)
Nature
, vol.441
, pp. 1080-1086
-
-
Rando, T.A.1
-
26
-
-
33846409030
-
Sarcopenia: Age-related skeletal muscle changes from determinants to physical disability
-
PMID: 17166393
-
Di Iorio IA, Abate M, Di RD, Russolillo A, Battaglini C, Ripari P, et al. Sarcopenia: age-related skeletal muscle changes from determinants to physical disability. Int J Immunopathol Pharmacol 2006; 19:703-19; PMID: 17166393.
-
(2006)
Int J Immunopathol Pharmacol
, vol.19
, pp. 703-719
-
-
Di Iorio, I.A.1
Abate, M.2
Di, R.D.3
Russolillo, A.4
Battaglini, C.5
Ripari, P.6
-
27
-
-
77955722198
-
Revisiting the antagonistic pleiotropy theory of aging: TOR-driven program and quasi-program
-
PMID: 20724817; DOI: 10.4161/cc.9.16.13120
-
Blagosklonny MV. Revisiting the antagonistic pleiotropy theory of aging: TOR-driven program and quasi-program. Cell Cycle 2010; 9:3151-6; PMID: 20724817; DOI: 10.4161/cc.9.16.13120.
-
(2010)
Cell Cycle
, vol.9
, pp. 3151-3156
-
-
Blagosklonny, M.V.1
-
28
-
-
35948982621
-
The role of autophagy in aging: Its essential part in the anti-aging mechanism of caloric restriction
-
DOI: 10.1196/annals.1396.020
-
Bergamini E, Cavallini G, Donati A, Gori Z. The role of autophagy in aging: its essential part in the anti-aging mechanism of caloric restriction. Ann NY Acad Sci 2007; 1114:69-78; DOI: 10.1196/annals.1396.020.
-
(2007)
Ann NY Acad Sci
, vol.1114
, pp. 69-78
-
-
Bergamini, E.1
Cavallini, G.2
Donati, A.3
Gori, Z.4
-
29
-
-
47949099098
-
Origin and physiological roles of inflammation
-
PMID: 18650913; DOI: 10.1038/nature07201
-
Medzhitov R. Origin and physiological roles of inflammation. Nature 2008; 454:428-35; PMID: 18650913; DOI: 10.1038/nature07201.
-
(2008)
Nature
, vol.454
, pp. 428-435
-
-
Medzhitov, R.1
|