-
1
-
-
77955167321
-
Multifaceted polo-like kinases: Drug targets and antitargets for cancer therapy
-
Strebhardt K. Multifaceted polo-like kinases: Drug targets and antitargets for cancer therapy. Nat Rev Drug Discov 2010; 9:643-60.
-
(2010)
Nat Rev Drug Discov
, vol.9
, pp. 643-660
-
-
Strebhardt, K.1
-
2
-
-
66349088501
-
Functional dynamics of Polo-like kinase 1 at the centrosome
-
Kishi K, van Vugt MA, Okamoto K, Hayashi Y, Yaffe MB. Functional dynamics of Polo-like kinase 1 at the centrosome. Mol Cell Biol 2009; 29:3134-50.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 3134-3150
-
-
Kishi, K.1
Van Vugt, M.A.2
Okamoto, K.3
Hayashi, Y.4
Yaffe, M.B.5
-
3
-
-
37249011204
-
AMPK/LKB1 signaling in epithelial cell polarity and cell division
-
Brenman JE. AMPK/LKB1 signaling in epithelial cell polarity and cell division. Cell Cycle 2007; 6:2755-9. (Pubitemid 350277166)
-
(2007)
Cell Cycle
, vol.6
, Issue.22
, pp. 2755-2759
-
-
Brenman, J.E.1
-
4
-
-
34548553073
-
AMPK links energy status to cell structure and mitosis
-
DOI 10.1016/j.bbrc.2007.08.016, PII S0006291X07017214
-
Koh H, Chung J. AMPK links energy status to cell structure and mitosis. Biochem Biophys Res Commun 2007; 362:789-92. (Pubitemid 47390643)
-
(2007)
Biochemical and Biophysical Research Communications
, vol.362
, Issue.4
, pp. 789-792
-
-
Koh, H.1
Chung, J.2
-
5
-
-
41149117383
-
LKB1 and AMPK in cell polarity and division
-
Williams T, Brenman JE. LKB1 and AMPK in cell polarity and division. Trends Cell Biol 2008; 18:193-8.
-
(2008)
Trends Cell Biol
, vol.18
, pp. 193-198
-
-
Williams, T.1
Brenman, J.E.2
-
6
-
-
66849093704
-
Genome-wide inhibitory impact of the AMPK activator metformin on [kinesins, tubulins, histones, auroras and polo-like kinases] M-phase cell cycle genes in human breast cancer cells
-
Oliveras-Ferraros C, Vazquez-Martin A, Menendez JA. Genome-wide inhibitory impact of the AMPK activator metformin on [kinesins, tubulins, histones, auroras and polo-like kinases] M-phase cell cycle genes in human breast cancer cells. Cell Cycle 2009; 8:1633-6.
-
(2009)
Cell Cycle
, vol.8
, pp. 1633-1636
-
-
Oliveras-Ferraros, C.1
Vazquez-Martin, A.2
Menendez, J.A.3
-
8
-
-
68449094064
-
The active form of the metabolic sensor: AMP-activated protein kinase (AMPK) directly binds the mitotic apparatus and travels from centrosomes to the spindle midzone during mitosis and cytokinesis
-
Vazquez-Martin A, Oliveras-Ferraros C, Menendez JA. The active form of the metabolic sensor: AMP-activated protein kinase (AMPK) directly binds the mitotic apparatus and travels from centrosomes to the spindle midzone during mitosis and cytokinesis. Cell Cycle 2009; 8:2385-98.
-
(2009)
Cell Cycle
, vol.8
, pp. 2385-2398
-
-
Vazquez-Martin, A.1
Oliveras-Ferraros, C.2
Menendez, J.A.3
-
9
-
-
69749099245
-
AMPK: Sensing energy to travel in mitosis
-
Carmena M. AMPK: Sensing energy to travel in mitosis. Cell Cycle 2009; 8:2682-3.
-
(2009)
Cell Cycle
, vol.8
, pp. 2682-2683
-
-
Carmena, M.1
-
11
-
-
0029079267
-
Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function
-
Golsteyn RM, Mundt KE, Fry AM, Nigg EA. Cell cycle regulation of the activity and subcellular localization of Plk1, a human protein kinase implicated in mitotic spindle function. J Cell Biol 1995; 129:1617-28.
-
(1995)
J Cell Biol
, vol.129
, pp. 1617-1628
-
-
Golsteyn, R.M.1
Mundt, K.E.2
Fry, A.M.3
Nigg, E.A.4
-
12
-
-
33847403132
-
In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1
-
Lansing TJ, McConnell RT, Duckett DR, Spehar GM, Knick VB, Hassler DF, et al. In vitro biological activity of a novel small-molecule inhibitor of polo-like kinase 1. Mol Cancer Ther 2007; 6:450-9.
-
(2007)
Mol Cancer Ther
, vol.6
, pp. 450-459
-
-
Lansing, T.J.1
McConnell, R.T.2
Duckett, D.R.3
Spehar, G.M.4
Knick, V.B.5
Hassler, D.F.6
-
13
-
-
33645316142
-
Targeting polo-like kinase 1 for cancer therapy
-
Strebhardt K, Ullrich A. Targeting polo-like kinase 1 for cancer therapy. Nat Rev Cancer 2006; 6:321-30.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 321-330
-
-
Strebhardt, K.1
Ullrich, A.2
-
14
-
-
51349144633
-
Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery
-
Macurek L, Lindqvist A, Lim D, Lampson MA, Klompmaker R, Freire R, et al. Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery. Nature 2008; 455:119-23.
-
(2008)
Nature
, vol.455
, pp. 119-123
-
-
Macurek, L.1
Lindqvist, A.2
Lim, D.3
Lampson, M.A.4
Klompmaker, R.5
Freire, R.6
-
17
-
-
34948818671
-
Use of the novel Plk1 inhibitor ZK-thiazolidinone to elucidate functions of Plk1 in early and late stages of mitosis
-
DOI 10.1091/mbc.E07-05-0517
-
Santamaria A, Neef R, Eberspächer U, Eis K, Husemann M, Mumberg D, et al. Use of the novel Plk1 inhibitor ZK-thiazolidinone to elucidate functions of Plk1 in early and late stages of mitosis. Mol Biol Cell 2007; 18:4024-36. (Pubitemid 47519493)
-
(2007)
Molecular Biology of the Cell
, vol.18
, Issue.10
, pp. 4024-4036
-
-
Santamaria, A.1
Neef, R.2
Eberspacher, U.3
Eis, K.4
Husemann, M.5
Mumberg, D.6
Prechtl, S.7
Schulze, V.8
Siemeister, G.9
Wortmann, L.10
Barr, F.A.11
Nigg, E.A.12
-
18
-
-
33750238670
-
Probing cell-division phenotype space and Polo-like kinase function using small molecules
-
DOI 10.1038/nchembio826, PII NCHEMBIO826
-
Peters U, Cherian J, Kim JH, Kwok BH, Kapoor TM. Probing cell-division phenotype space and Pololike kinase function using small molecules. Nat Chem Biol 2006; 2:618-26. (Pubitemid 44610346)
-
(2006)
Nature Chemical Biology
, vol.2
, Issue.11
, pp. 618-626
-
-
Peters, U.1
Cherian, J.2
Kim, J.H.3
Kwok, B.H.4
Kapoor, T.M.5
-
19
-
-
33846931644
-
The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1
-
Lénárt P, Petronczki M, Steegmaier M, Di Fiore B, Lipp JJ, Hoffmann M, et al. The small-molecule inhibitor BI 2536 reveals novel insights into mitotic roles of polo-like kinase 1. Curr Biol 2007; 17:304-15.
-
(2007)
Curr Biol
, vol.17
, pp. 304-315
-
-
Lénárt, P.1
Petronczki, M.2
Steegmaier, M.3
Di Fiore, B.4
Lipp, J.J.5
Hoffmann, M.6
-
20
-
-
32244446180
-
A functional interplay between Aurora-A, Plk1 and TPX2 at spindle poles: Plk1 controls centrosomal localization of Aurora-A and TPX2 spindle association
-
De Luca M, Lavia P, Guarguaglini G. A functional interplay between Aurora-A, Plk1 and TPX2 at spindle poles: Plk1 controls centrosomal localization of Aurora-A and TPX2 spindle association. Cell Cycle 2006; 5:296-303.
-
(2006)
Cell Cycle
, vol.5
, pp. 296-303
-
-
De Luca, M.1
Lavia, P.2
Guarguaglini, G.3
-
21
-
-
30044436805
-
Different Plk1 functions show distinct dependencies on polo-box domain-mediated targeting
-
DOI 10.1091/mbc.E05-08-0801
-
Hanisch A, Wehner A, Nigg EA, Silljé HH. Different Plk1 functions show distinct dependencies on Polo-Box domain-mediated targeting. Mol Biol Cell 2006; 17:448-59. (Pubitemid 43049496)
-
(2006)
Molecular Biology of the Cell
, vol.17
, Issue.1
, pp. 448-459
-
-
Hanisch, A.1
Wehner, A.2
Nigg, E.A.3
Sillje, H.H.W.4
-
22
-
-
0036896143
-
Cohesin release is required for sister chromatid resolution, but not for condensin-mediated compaction, at the onset of mitosis
-
DOI 10.1101/gad.249202
-
Losada A, Hirano M, Hirano T. Cohesin release is required for sister chromatid resolution, but not for condensin-mediated compaction, at the onset of mitosis. Genes Dev 2002; 16:3004-16. (Pubitemid 35424189)
-
(2002)
Genes and Development
, vol.16
, Issue.23
, pp. 3004-3016
-
-
Losada, A.1
Hirano, M.2
Hirano, T.3
-
23
-
-
34250827107
-
Energy-dependent regulation of cell structure by AMP-activated protein kinase
-
DOI 10.1038/nature05828, PII NATURE05828
-
Lee JH, Koh H, Kim M, Kim Y, Lee SY, Karess RE, et al. Energy-dependent regulation of cell structure by AMP-activated protein kinase. Nature 2007; 447:1017-20. (Pubitemid 46975745)
-
(2007)
Nature
, vol.447
, Issue.7147
, pp. 1017-1020
-
-
Lee, J.H.1
Koh, H.2
Kim, M.3
Kim, Y.4
Lee, S.Y.5
Karess, R.E.6
Lee, S.-H.7
Shong, M.8
Kim, J.-M.9
Kim, J.10
Chung, J.11
-
24
-
-
78651079847
-
The Plk1-dependent phosphoproteome of the early mitotic spindle
-
Santamaria A, Wang B, Elowe S, Malik R, Zhang F, Bauer M, et al. The Plk1-dependent phosphoproteome of the early mitotic spindle. Mol Cell Proteomics 2011; 10:M110.004457.
-
(2011)
Mol Cell Proteomics
, vol.10
-
-
Santamaria, A.1
Wang, B.2
Elowe, S.3
Malik, R.4
Zhang, F.5
Bauer, M.6
-
25
-
-
0033512308
-
Mitotic effects of a constitutively active mutant of the Xenopus polo- Like kinase Plx1
-
Qian YW, Erikson E, Maller JL. Mitotic effects of a constitutively active mutant of the Xenopus polo-like kinase Plx1. Mol Cell Biol 1999; 19:8625-32. (Pubitemid 30414055)
-
(1999)
Molecular and Cellular Biology
, vol.19
, Issue.12
, pp. 8625-8632
-
-
Qian, Y.-W.1
Erikson, E.2
Maller, J.L.3
-
26
-
-
40949133430
-
Plx1 is required for chromosomal DNA replication under stressful conditions
-
Trenz K, Errico A, Costanzo V. Plx1 is required for chromosomal DNA replication under stressful conditions. EMBO J 2008; 27:876-85.
-
(2008)
EMBO J
, vol.27
, pp. 876-885
-
-
Trenz, K.1
Errico, A.2
Costanzo, V.3
-
28
-
-
58149354672
-
Polo-like kinase 1 phosphorylates and regulates Bcl-xL during pironetin induced apoptosis
-
Tamura Y, Simizu S, Muroi M, Takagi S, Kawatani M, Watanabe N, et al. Polo-like kinase 1 phosphorylates and regulates Bcl-xL during pironetin induced apoptosis. Oncogene 2009; 28:107-16.
-
(2009)
Oncogene
, vol.28
, pp. 107-116
-
-
Tamura, Y.1
Simizu, S.2
Muroi, M.3
Takagi, S.4
Kawatani, M.5
Watanabe, N.6
-
29
-
-
77953589376
-
A functional link between polo-like kinase 1 and the mammalian target-ofrapamycin pathway?
-
Renner AG, Créancier L, Dos Santos C, Fialin C, Recher C, Bailly C, et al. A functional link between polo-like kinase 1 and the mammalian target-ofrapamycin pathway? Cell Cycle 2010; 9:1690-6.
-
(2010)
Cell Cycle
, vol.9
, pp. 1690-1696
-
-
Renner, A.G.1
Créancier, L.2
Dos Santos, C.3
Fialin, C.4
Recher, C.5
Bailly, C.6
-
30
-
-
60549112707
-
The serine 2481-autophosphorylated form of mammalian Target of Rapamycin (mTOR) is localized to midzone and midbody in dividing cancer cells
-
Vazquez-Martin A, Oliveras-Ferraros C, Bernadó L, López-Bonet E, Menendez JA. The serine 2481-autophosphorylated form of mammalian Target Of Rapamycin (mTOR) is localized to midzone and midbody in dividing cancer cells. Biochem Biophys Res Commun 2009; 380:638-43.
-
(2009)
Biochem Biophys Res Commun
, vol.380
, pp. 638-643
-
-
Vazquez-Martin, A.1
Oliveras-Ferraros, C.2
Bernadó, L.3
López-Bonet, E.4
Menendez, J.A.5
-
31
-
-
74549168015
-
Serine 2481-autophosphorylation of mammalian target of rapamycin (mTOR) couples with chromosome condensation and segregation during mitosis: Confocal microscopy characterization and immunohistochemical validation of PP-mTOR(Ser2481) as a novel high-contrast mitosis marker in breast cancer core biopsies
-
Lopez-Bonet E, Vazquez-Martin A, Pérez-Martínez MC, Oliveras-Ferraros C, Pérez-Bueno F, Bernadó L, et al. Serine 2481-autophosphorylation of mammalian target of rapamycin (mTOR) couples with chromosome condensation and segregation during mitosis: confocal microscopy characterization and immunohistochemical validation of PP-mTOR(Ser2481) as a novel high-contrast mitosis marker in breast cancer core biopsies. Int J Oncol 2010; 36:107-15.
-
(2010)
Int J Oncol
, vol.36
, pp. 107-115
-
-
Lopez-Bonet, E.1
Vazquez-Martin, A.2
Pérez-Martínez, M.C.3
Oliveras-Ferraros, C.4
Pérez-Bueno, F.5
Bernadó, L.6
-
32
-
-
30444454338
-
CLIP-170 facilitates the formation of kinetochore-microtubule attachments
-
DOI 10.1038/sj.emboj.7600916, PII 7600916
-
Tanenbaum ME, Galjart N, van Vugt MA, Medema RH. CLIP-170 facilitates the formation of kinetochoremicrotubule attachments. EMBO J 2006; 25:45-57. (Pubitemid 43077294)
-
(2006)
EMBO Journal
, vol.25
, Issue.1
, pp. 45-57
-
-
Tanenbaum, M.E.1
Galjart, N.2
Van Vugt, M.A.T.M.3
Medema, R.H.4
-
33
-
-
77956394930
-
Phosphorylation of CLIP-170 by Plk1 and CK2 promotes timely formation of kinetochore-microtubule attachments
-
Li H, Liu XS, Yang X, Wang Y, Wang Y, Turner JR, et al. Phosphorylation of CLIP-170 by Plk1 and CK2 promotes timely formation of kinetochore-microtubule attachments. EMBO J 2010; 29:2953-65.
-
(2010)
EMBO J
, vol.29
, pp. 2953-2965
-
-
Li, H.1
Liu, X.S.2
Yang, X.3
Wang, Y.4
Wang, Y.5
Turner, J.R.6
-
34
-
-
77953121697
-
AMPK controls the speed of microtubule polymerization and directional cell migration through CLIP-170 phosphorylation
-
Nakano A, Kato H, Watanabe T, Min KD, Yamazaki S, Asano Y, et al. AMPK controls the speed of microtubule polymerization and directional cell migration through CLIP-170 phosphorylation. Nat Cell Biol 2010; 12:583-90.
-
(2010)
Nat Cell Biol
, vol.12
, pp. 583-590
-
-
Nakano, A.1
Kato, H.2
Watanabe, T.3
Min, K.D.4
Yamazaki, S.5
Asano, Y.6
-
35
-
-
0036774805
-
The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase
-
DOI 10.1093/embo-reports/kvf197
-
Choi JH, Bertram PG, Drenan R, Carvalho J, Zhou HH, Zheng XF. The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase. EMBO Rep 2002; 3:988-94. (Pubitemid 35256474)
-
(2002)
EMBO Reports
, vol.3
, Issue.10
, pp. 988-994
-
-
Choi, J.H.1
Bertram, P.G.2
Drenan, R.3
Carvalho, J.4
Zhou, H.H.5
Zheng, X.F.S.6
|