-
1
-
-
0029804116
-
Mechanism of activation of protein kinase B by insulin and IGF-1
-
D.R. Alessi, M. Andjelkovic, B. Caudwell, P. Cron, N. Morrice, P. Cohen, and B.A. Hemmings Mechanism of activation of protein kinase B by insulin and IGF-1 EMBO J. 15 1996 6541 6551
-
(1996)
EMBO J.
, vol.15
, pp. 6541-6551
-
-
Alessi, D.R.1
Andjelkovic, M.2
Caudwell, B.3
Cron, P.4
Morrice, N.5
Cohen, P.6
Hemmings, B.A.7
-
2
-
-
0032518467
-
3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro
-
D.R. Alessi, M.T. Kozlowski, Q.P. Weng, N. Morrice, and J. Avruch 3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro Curr. Biol. 8 1998 69 81
-
(1998)
Curr. Biol.
, vol.8
, pp. 69-81
-
-
Alessi, D.R.1
Kozlowski, M.T.2
Weng, Q.P.3
Morrice, N.4
Avruch, J.5
-
3
-
-
0029942186
-
Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors
-
M. Andjelkovic, T. Jakubowicz, P. Cron, X.F. Ming, J.W. Han, and B.A. Hemmings Activation and phosphorylation of a pleckstrin homology domain containing protein kinase (RAC-PK/PKB) promoted by serum and protein phosphatase inhibitors Proc. Natl. Acad. Sci. USA 93 1996 5699 5704
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 5699-5704
-
-
Andjelkovic, M.1
Jakubowicz, T.2
Cron, P.3
Ming, X.F.4
Han, J.W.5
Hemmings, B.A.6
-
4
-
-
0033565608
-
The hydrophobic phosphorylation motif of conventional protein kinase C is regulated by autophosphorylation
-
A. Behn-Krappa, and A.C. Newton The hydrophobic phosphorylation motif of conventional protein kinase C is regulated by autophosphorylation Curr. Biol. 9 1999 728 737
-
(1999)
Curr. Biol.
, vol.9
, pp. 728-737
-
-
Behn-Krappa, A.1
Newton, A.C.2
-
5
-
-
0034168037
-
Protein kinase C-mediated regulation of the cell cycle
-
J.D. Black Protein kinase C-mediated regulation of the cell cycle Front. Biosci. 5 2000 D406 D423
-
(2000)
Front. Biosci.
, vol.5
-
-
Black, J.D.1
-
6
-
-
0031021875
-
Phosphorylation of protein kinase C-alpha on serine 657 controls the accumulation of active enzyme and contributes to its phosphatase- resistant state
-
F. Bornancin, and P.J. Parker Phosphorylation of protein kinase C-alpha on serine 657 controls the accumulation of active enzyme and contributes to its phosphatase- resistant state J. Biol. Chem. 272 1997 3544 3549
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 3544-3549
-
-
Bornancin, F.1
Parker, P.J.2
-
7
-
-
0035872199
-
Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation
-
J. Brognard, A.S. Clark, Y. Ni, and P.A. Dennis Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation Cancer Res. 61 2001 3986 3997
-
(2001)
Cancer Res.
, vol.61
, pp. 3986-3997
-
-
Brognard, J.1
Clark, A.S.2
Ni, Y.3
Dennis, P.A.4
-
8
-
-
0034612276
-
Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways
-
J.C. Clemens, C.A. Worby, N. Simonson-Leff, M. Muda, T. Maehama, B.A. Hemmings, and J.E. Dixon Use of double-stranded RNA interference in Drosophila cell lines to dissect signal transduction pathways Proc. Natl. Acad. Sci. USA 97 2000 6499 6503
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 6499-6503
-
-
Clemens, J.C.1
Worby, C.A.2
Simonson-Leff, N.3
Muda, M.4
Maehama, T.5
Hemmings, B.A.6
Dixon, J.E.7
-
9
-
-
0024792262
-
Protein phosphatases come of age
-
P. Cohen, and P.T. Cohen Protein phosphatases come of age J. Biol. Chem. 264 1989 21435 21438
-
(1989)
J. Biol. Chem.
, vol.264
, pp. 21435-21438
-
-
Cohen, P.1
Cohen, P.T.2
-
10
-
-
0030465532
-
Crystal structure of the protein serine/threonine phosphatase 2C at 2.0 a resolution
-
A.K. Das, N.R. Helps, P.T. Cohen, and D. Barford Crystal structure of the protein serine/threonine phosphatase 2C at 2.0 A resolution EMBO J. 15 1996 6798 6809
-
(1996)
EMBO J.
, vol.15
, pp. 6798-6809
-
-
Das, A.K.1
Helps, N.R.2
Cohen, P.T.3
Barford, D.4
-
11
-
-
0032752063
-
Cellular survival: A play in three Akts
-
S.R. Datta, A. Brunet, and M.E. Greenberg Cellular survival: a play in three Akts Genes Dev. 13 1999 2905 2927
-
(1999)
Genes Dev.
, vol.13
, pp. 2905-2927
-
-
Datta, S.R.1
Brunet, A.2
Greenberg, M.E.3
-
12
-
-
0030875555
-
Phosphorylation at conserved carboxyl-terminal hydrophobic motif regulates the catalytic and regulatory domains of protein kinase C
-
A.S. Edwards, and A.C. Newton Phosphorylation at conserved carboxyl-terminal hydrophobic motif regulates the catalytic and regulatory domains of protein kinase C J. Biol. Chem. 272 1997 18382 18390
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 18382-18390
-
-
Edwards, A.S.1
Newton, A.C.2
-
13
-
-
0033635275
-
Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains
-
K.M. Ferguson, J.M. Kavran, V.G. Sankaran, E. Fournier, S.J. Isakoff, E.Y. Skolnik, and M.A. Lemmon Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains Mol. Cell 6 2000 373 384
-
(2000)
Mol. Cell
, vol.6
, pp. 373-384
-
-
Ferguson, K.M.1
Kavran, J.M.2
Sankaran, V.G.3
Fournier, E.4
Isakoff, S.J.5
Skolnik, E.Y.6
Lemmon, M.A.7
-
14
-
-
0033575250
-
Kinetic analysis of human serine/threonine protein phosphatase 2C alpha
-
C.C. Fjeld, and J.M. Denu Kinetic analysis of human serine/threonine protein phosphatase 2C alpha J. Biol. Chem. 274 1999 20336 20343
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 20336-20343
-
-
Fjeld, C.C.1
Denu, J.M.2
-
15
-
-
0030907987
-
PI3K: Downstream AKTion blocks apoptosis
-
T.F. Franke, D.R. Kaplan, and L.C. Cantley PI3K: downstream AKTion blocks apoptosis Cell 88 1997 435 437
-
(1997)
Cell
, vol.88
, pp. 435-437
-
-
Franke, T.F.1
Kaplan, D.R.2
Cantley, L.C.3
-
16
-
-
0030728479
-
Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain
-
F.B. Furnari, H. Lin, H.S. Huang, and W.K. Cavenee Growth suppression of glioma cells by PTEN requires a functional phosphatase catalytic domain Proc. Natl. Acad. Sci. USA 94 1997 12479 12484
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 12479-12484
-
-
Furnari, F.B.1
Lin, H.2
Huang, H.S.3
Cavenee, W.K.4
-
17
-
-
0035380478
-
The carboxyl terminus of protein kinase c provides a switch to regulate its interaction with the phosphoinositide-dependent kinase, pdk-1
-
T. Gao, A. Toker, and A.C. Newton The carboxyl terminus of protein kinase c provides a switch to regulate its interaction with the phosphoinositide- dependent kinase, pdk-1 J. Biol. Chem. 276 2001 19588 19596
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 19588-19596
-
-
Gao, T.1
Toker, A.2
Newton, A.C.3
-
18
-
-
0037379737
-
Characterization of sporadic colon cancer by patterns of genomic instability
-
A. Goel, C.N. Arnold, D. Niedzwiecki, D.K. Chang, L. Ricciardiello, J.M. Carethers, J.M. Dowell, L. Wasserman, C. Compton, and R.J. Mayer Characterization of sporadic colon cancer by patterns of genomic instability Cancer Res. 63 2003 1608 1614
-
(2003)
Cancer Res.
, vol.63
, pp. 1608-1614
-
-
Goel, A.1
Arnold, C.N.2
Niedzwiecki, D.3
Chang, D.K.4
Ricciardiello, L.5
Carethers, J.M.6
Dowell, J.M.7
Wasserman, L.8
Compton, C.9
Mayer, R.J.10
-
19
-
-
1542328927
-
Structure, regulation and function of PKB/AKT - A major therapeutic target
-
M. Hanada, J. Feng, and B.A. Hemmings Structure, regulation and function of PKB/AKT - a major therapeutic target Biochim. Biophys. Acta 1697 2004 3 16
-
(2004)
Biochim. Biophys. Acta
, vol.1697
, pp. 3-16
-
-
Hanada, M.1
Feng, J.2
Hemmings, B.A.3
-
20
-
-
0035854677
-
Insulin-stimulated protein kinase B phosphorylation on Ser-473 is independent of its activity and occurs through a staurosporine-insensitive kinase
-
M.M. Hill, M. Andjelkovic, D.P. Brazil, S. Ferrari, D. Fabbro, and B.A. Hemmings Insulin-stimulated protein kinase B phosphorylation on Ser-473 is independent of its activity and occurs through a staurosporine-insensitive kinase J. Biol. Chem. 276 2001 25643 25646
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 25643-25646
-
-
Hill, M.M.1
Andjelkovic, M.2
Brazil, D.P.3
Ferrari, S.4
Fabbro, D.5
Hemmings, B.A.6
-
21
-
-
0032977124
-
Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines
-
N. Ishii, D. Maier, A. Merlo, M. Tada, Y. Sawamura, A.C. Diserens, and E.G. Van Meir Frequent co-alterations of TP53, p16/CDKN2A, p14ARF, PTEN tumor suppressor genes in human glioma cell lines Brain Pathol. 9 1999 469 479
-
(1999)
Brain Pathol.
, vol.9
, pp. 469-479
-
-
Ishii, N.1
Maier, D.2
Merlo, A.3
Tada, M.4
Sawamura, Y.5
Diserens, A.C.6
Van Meir, E.G.7
-
22
-
-
0037779029
-
Probing the function of conserved residues in the serine/threonine phosphatase PP2Calpha
-
M.D. Jackson, C.C. Fjeld, and J.M. Denu Probing the function of conserved residues in the serine/threonine phosphatase PP2Calpha Biochemistry 42 2003 8513 8521
-
(2003)
Biochemistry
, vol.42
, pp. 8513-8521
-
-
Jackson, M.D.1
Fjeld, C.C.2
Denu, J.M.3
-
23
-
-
0028321495
-
Allelic loss of chromosome 18q and prognosis in colorectal cancer
-
J. Jen, H. Kim, S. Piantadosi, Z.F. Liu, R.C. Levitt, P. Sistonen, K.W. Kinzler, B. Vogelstein, and S.R. Hamilton Allelic loss of chromosome 18q and prognosis in colorectal cancer N. Engl. J. Med. 331 1994 213 221
-
(1994)
N. Engl. J. Med.
, vol.331
, pp. 213-221
-
-
Jen, J.1
Kim, H.2
Piantadosi, S.3
Liu, Z.F.4
Levitt, R.C.5
Sistonen, P.6
Kinzler, K.W.7
Vogelstein, B.8
Hamilton, S.R.9
-
24
-
-
0029789485
-
Loss of 18q and homozygosity for the DCC locus: Possible markers for clinically aggressive squamous cell carcinoma
-
W. Kelker, D.L. Van Dyke, M.J. Worsham, P.L. Christopherson, C.D. James, M.R. Conlon, and T.E. Carey Loss of 18q and homozygosity for the DCC locus: possible markers for clinically aggressive squamous cell carcinoma Anticancer Res. 16 1996 2365 2372
-
(1996)
Anticancer Res.
, vol.16
, pp. 2365-2372
-
-
Kelker, W.1
Van Dyke, D.L.2
Worsham, M.J.3
Christopherson, P.L.4
James, C.D.5
Conlon, M.R.6
Carey, T.E.7
-
25
-
-
0029615509
-
Protein kinase C is regulated in vivo by three functionally distinct phosphorylations
-
L.M. Keranen, E.M. Dutil, and A.C. Newton Protein kinase C is regulated in vivo by three functionally distinct phosphorylations Curr. Biol. 5 1995 1394 1403
-
(1995)
Curr. Biol.
, vol.5
, pp. 1394-1403
-
-
Keranen, L.M.1
Dutil, E.M.2
Newton, A.C.3
-
26
-
-
0034845958
-
PKB/Akt: A key mediator of cell proliferation, survival and insulin responses?
-
M.A. Lawlor, and D.R. Alessi PKB/Akt: a key mediator of cell proliferation, survival and insulin responses? J. Cell Sci. 114 2001 2903 2910
-
(2001)
J. Cell Sci.
, vol.114
, pp. 2903-2910
-
-
Lawlor, M.A.1
Alessi, D.R.2
-
27
-
-
0035413599
-
Phosphoinositide-regulated kinases and phosphoinositide phosphatases
-
N.R. Leslie, R.M. Biondi, and D.R. Alessi Phosphoinositide-regulated kinases and phosphoinositide phosphatases Chem. Rev. 101 2001 2365 2380
-
(2001)
Chem. Rev.
, vol.101
, pp. 2365-2380
-
-
Leslie, N.R.1
Biondi, R.M.2
Alessi, D.R.3
-
28
-
-
0032577699
-
The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
-
T. Maehama, and J.E. Dixon The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate J. Biol. Chem. 273 1998 13375 13378
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 13375-13378
-
-
Maehama, T.1
Dixon, J.E.2
-
29
-
-
0042750799
-
Akt and PI 3-kinase signaling in cardiomyocyte hypertrophy and survival
-
T. Matsui, T. Nagoshi, and A. Rosenzweig Akt and PI 3-kinase signaling in cardiomyocyte hypertrophy and survival Cell Cycle 2 2003 220 223
-
(2003)
Cell Cycle
, vol.2
, pp. 220-223
-
-
Matsui, T.1
Nagoshi, T.2
Rosenzweig, A.3
-
30
-
-
0037337159
-
Regulation of the ABC kinases by phosphorylation: Protein kinase C as a paradigm
-
A.C. Newton Regulation of the ABC kinases by phosphorylation: protein kinase C as a paradigm Biochem. J. 370 2003 361 371
-
(2003)
Biochem. J.
, vol.370
, pp. 361-371
-
-
Newton, A.C.1
-
31
-
-
0036185848
-
The protein kinase B/Akt signalling pathway in human malignancy
-
K.M. Nicholson, and N.G. Anderson The protein kinase B/Akt signalling pathway in human malignancy Cell. Signal. 14 2002 381 395
-
(2002)
Cell. Signal.
, vol.14
, pp. 381-395
-
-
Nicholson, K.M.1
Anderson, N.G.2
-
32
-
-
0141639767
-
Autocrine signalling through erbB receptors promotes constitutive activation of protein kinase B/Akt in breast cancer cell lines
-
K.M. Nicholson, C.H. Streuli, and N.G. Anderson Autocrine signalling through erbB receptors promotes constitutive activation of protein kinase B/Akt in breast cancer cell lines Breast Cancer Res. Treat. 81 2003 117 128
-
(2003)
Breast Cancer Res. Treat.
, vol.81
, pp. 117-128
-
-
Nicholson, K.M.1
Streuli, C.H.2
Anderson, N.G.3
-
33
-
-
0028146767
-
A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity
-
R. Nishikawa, X.D. Ji, R.C. Harmon, C.S. Lazar, G.N. Gill, W.K. Cavenee, and H.J. Huang A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity Proc. Natl. Acad. Sci. USA 91 1994 7727 7731
-
(1994)
Proc. Natl. Acad. Sci. USA
, vol.91
, pp. 7727-7731
-
-
Nishikawa, R.1
Ji, X.D.2
Harmon, R.C.3
Lazar, C.S.4
Gill, G.N.5
Cavenee, W.K.6
Huang, H.J.7
-
34
-
-
0032854063
-
SCOP, a novel gene product expressed in a circadian manner in rat suprachiasmatic nucleus
-
K. Shimizu, M. Okada, A. Takano, and K. Nagai SCOP, a novel gene product expressed in a circadian manner in rat suprachiasmatic nucleus FEBS Lett. 458 1999 363 369
-
(1999)
FEBS Lett.
, vol.458
, pp. 363-369
-
-
Shimizu, K.1
Okada, M.2
Takano, A.3
Nagai, K.4
-
35
-
-
0032578999
-
Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B
-
L. Stephens, K. Anderson, D. Stokoe, H. Erdjument-Bromage, G.F. Painter, A.B. Holmes, P.R.J. Gaffney, C.B. Reese, F. McCormick, and P. Tempst Protein kinase B kinases that mediate phosphatidylinositol 3,4,5-trisphosphate-dependent activation of protein kinase B Science 279 1998 710 714
-
(1998)
Science
, vol.279
, pp. 710-714
-
-
Stephens, L.1
Anderson, K.2
Stokoe, D.3
Erdjument-Bromage, H.4
Painter, G.F.5
Holmes, A.B.6
Gaffney, P.R.J.7
Reese, C.B.8
McCormick, F.9
Tempst, P.10
-
36
-
-
0034708482
-
Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site
-
A. Toker, and A.C. Newton Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site J. Biol. Chem. 275 2000 8271 8274
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 8271-8274
-
-
Toker, A.1
Newton, A.C.2
-
37
-
-
0036632368
-
The phosphatidylinositol 3-Kinase AKT pathway in human cancer
-
I. Vivanco, and C.L. Sawyers The phosphatidylinositol 3-Kinase AKT pathway in human cancer Nat. Rev. Cancer 2 2002 489 501
-
(2002)
Nat. Rev. Cancer
, vol.2
, pp. 489-501
-
-
Vivanco, I.1
Sawyers, C.L.2
-
38
-
-
0036899518
-
PTEN and myotubularin phosphatases: From 3-phosphoinositide dephosphorylation to disease
-
M.J. Wishart, and J.E. Dixon PTEN and myotubularin phosphatases: from 3-phosphoinositide dephosphorylation to disease Trends Cell Biol. 12 2002 579 585
-
(2002)
Trends Cell Biol.
, vol.12
, pp. 579-585
-
-
Wishart, M.J.1
Dixon, J.E.2
-
39
-
-
0035895919
-
3-phosphoinositide-dependent protein kinase 1, an Akt1 kinase, is involved in dephosphorylation of Thr-308 of Akt1 in Chinese hamster ovary cells
-
T. Yamada, H. Katagiri, T. Asano, K. Inukai, M. Tsuru, T. Kodama, M. Kikuchi, and Y. Oka 3-phosphoinositide-dependent protein kinase 1, an Akt1 kinase, is involved in dephosphorylation of Thr-308 of Akt1 in Chinese hamster ovary cells J. Biol. Chem. 276 2001 5339 5345
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 5339-5345
-
-
Yamada, T.1
Katagiri, H.2
Asano, T.3
Inukai, K.4
Tsuru, M.5
Kodama, T.6
Kikuchi, M.7
Oka, Y.8
-
40
-
-
2542475897
-
Protein phosphatase-2C alpha as a positive regulator of insulin sensitivity through direct activation of phosphatidylinositol 3-kinase in 3T3-L1 adipocytes
-
T. Yoshizaki, H. Maegawa, K. Egawa, S. Ugi, Y. Nishio, T. Imamura, T. Kobayashi, S. Tamura, J.M. Olefsky, and A. Kashiwagi Protein phosphatase-2C alpha as a positive regulator of insulin sensitivity through direct activation of phosphatidylinositol 3-kinase in 3T3-L1 adipocytes J. Biol. Chem. 279 2004 22715 22726
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 22715-22726
-
-
Yoshizaki, T.1
Maegawa, H.2
Egawa, K.3
Ugi, S.4
Nishio, Y.5
Imamura, T.6
Kobayashi, T.7
Tamura, S.8
Olefsky, J.M.9
Kashiwagi, A.10
|