Both lipid- and protein-phosphatase activities of PTEN contribute to the p53-PTEN anti-invasion pathway

Cell Cycle

Volumn 9, Issue 22, 2010, Pages 4450-4454

  Poon, Jacquelyne S ^a   Eves, Robert ^a   Mak, Alan S ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

Cell invasion; Cell migration; p53; PTEN; Tumor suppressors; Vascular smooth muscle cells

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN P53; PROTEIN TYROSINE KINASE; RETROVIRUS VECTOR;

ANIMAL CELL; AORTA; ARTICLE; CELL INVASION; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; HEART MUSCLE CELL; MOLECULAR MECHANICS; NONHUMAN; PHENOTYPE; RAT; SMOOTH MUSCLE FIBER; UPREGULATION;

RATTUS;

EID: 78649872743     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.9.22.13936     Document Type: Article

References (39)

1. Owens GK, Kumar MS, Wamhoff BR. Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiol Rev 2004; 84:767-801.
2. Rudijanto A. The role of vascular smooth muscle cells on the pathogenesis of atherosclerosis. Acta Med Indones 2007; 39:86-93.
3. Kuzuya M, Iguchi A. Role of matrix metalloproteinases in vascular remodeling. J Atheroscler Thromb 2003; 10:275-82.
4. Abiges-Rizo C, Destaing O, Fourcade B, Planus E, Block MR. Actin machinery and mechanosensitivity in invadopodia, podosomes and focal adhesions. J Cell Sci 2009; 122:3037-49.
5. Linder S. The matrix corroded: podosomes and invadopodia in extracellular matrix degradation. Trends Cell Biol 2007; 17:107-17.
6. Rottiers P, Saltel F, Daubon T, et al. TGFbeta-induced endothelial podosomes mediate basement membrane collagen degradation in arterial vessels. J Cell Sci 2009; 122:4311-8.
7. Burgstaller G, Gimona M. Podosome-mediated matrix resorption and cell motility in vascular smooth muscle cells. Am J Physiol Heart Circ Physiol 2005; 288:3001-5.
8. Hai CM, Hahne P, Harrington EO, Gimona M. Conventional protein kinase C mediates phorbol-dibutyrate- induced cytoskeletal remodeling in a7r5 smooth muscle cells. Exp Cell Res 2002; 280:64-74.
9. Webb BA, Eves R, Crawley SW, Zhou S, Cote GP, Mak AS. PAK1 induces podosome formation in A7r5 vascular smooth muscle cells in a PAK-interacting exchange factor-dependent manner. Am J Physiol Cell Physiol 2005; 289:898-907.
10. Machesky L, Jurdic P, Hinz B. Grab, stick, pull and digest: the functional diversity of actin-associated matrix-adhesion structures. Workshop on Invadopodia, Podosomes and Focal Adhesions in Tissue Invasion. EMBO Rep 2008; 9:139-43.
11. Symons M. Cell biology: watching the first steps of podosome formation. Curr Biol 2008; 18:925-7.
12. Gimona M, Buccione R, Courtneidge SA, Linder S. Assembly and biological role of podosomes and invadopodia. Curr Opin Cell Biol 2008; 20:235-41.
13. Machesky LM, May RC. Arps: actin-related proteins. Results Probl Cell Differ 2001; 32:213-29.
14. Eves R, Webb BA, Zhou S, Mak AS. Caldesmon is an integral component of podosomes in smooth muscle cells. J Cell Sci 2006; 119:1691-702.
15. Webb BA, Eves R, Mak AS. Cortactin regulates podosome formation: roles of the protein interaction domains. Exp Cell Res 2006; 312:760-9.
16. Yamakita Y, Oosawa F, Yamashiro S, Matsumura F. Caldesmon inhibits Arp2/3-mediated actin nucleation. J Biol Chem 2003; 278:17937-44.
17. Yoshio T, Morita T, Kimura Y, Tsujii M, Hayashi N, Sobue K. Caldesmon suppresses cancer cell invasion by regulating podosome/invadopodium formation. FEBS Lett 2007; 581:3777-82.
18. Dovas A, Gevrey JC, Grossi A, Park H, bou-Kheir W, Cox D. Regulation of podosome dynamics by WASp phosphorylation: implication in matrix degradation and chemotaxis in macrophages. J Cell Sci 2009; 122:3873-82.
19. Mukhopadhyay UK, Eves R, Jia L, Mooney P, Mak AS. p53 suppresses Src-induced podosome and rosette formation and cellular invasiveness through the upregulation of caldesmon. Mol Cell Biol 2009; 29:3088-98.
20. Mukhopadhyay UK, Mooney P, Jia L, Eves R, Raptis L, Mak AS. Doubles Game: Src-Stat3 versus p53- PTEN in Cellular Migration and Invasion. Mol Cell Biol (Epub ahead of print, Aug 2010) 2010.
21. Xiao H, Eves R, Yeh C, Kan W, Xu F, Mak AS, et al. Phorbol ester-induced podosomes in normal human bronchial epithelial cells. J Cell Physiol 2009; 218:366-75.
22. Mukhopadhyay UK, Mak AS. p53: is the guardian of the genome also a suppressor of cell invasion? Cell Cycle 2009; 8:2481.
23. Wells A, Huttenlocher A, Lauffenburger DA. Calpain proteases in cell adhesion and motility. Int Rev Cytol 2005; 245:1-16.
24. Courtneidge SA, Azucena EF, Pass I, Seals DF, Tesfay L. The SRC substrate Tks5, podosomes (invadopodia) and cancer cell invasion. Cold Spring Harb Symp Quant Biol 2005; 70:167-71.
25. Quintavalle M, Elia L, Condorelli G, Courtneidge SA. MicroRNA control of podosome formation in vascular smooth muscle cells in vivo and in vitro. J Cell Biol 2010; 189:13-22.
26. Efeyan A, Serrano M. p53: guardian of the genome and policeman of the oncogenes. Cell Cycle 2007; 6:1006-10.
27. Jiang BH, Liu LZ. PI3K/PTEN signaling in angiogenesis and tumorigenesis. Adv Cancer Res 2009; 102:19-65.
28. Chalhoub N, Baker SJ. PTEN and the PI3-kinase pathway in cancer. Annu Rev Pathol 2009; 4:127-50.
29. Davidson L, Maccario H, Perera NM, et al. Suppression of cellular proliferation and invasion by the concerted lipid and protein phosphatase activities of PTEN. Oncogene 2010; 29:687-97.
30. Dey N, Crosswell HE, De P, et al. The protein phosphatase activity of PTEN regulates SRC family kinases and controls glioma migration. Cancer Res 2008; 68:1862-71.
31. Leslie NR, Yang X, Downes CP, Weijer CJ. PtdIns(3,4,5)P(3)-dependent and -independent roles for PTEN in the control of cell migration. Curr Biol 2007; 17:115-25.
32. Leslie NR, Maccario H, Spinelli L, Davidson L. The significance of PTEN's protein phosphatase activity. Adv Enzyme Regul 2009; 49:190-6.
33. Higuchi M, Onishi K, Kikuchi C, Gotoh Y. Scaffolding function of PAK in the PDK1-Akt pathway. Nat Cell Biol 2008; 10:1356-64.
34. Zhao ZS, Manser E. PAK and other Rho-associated kinases - effectors with surprisingly diverse mechanisms of regulation. Biochem J 2005; 386:201-14.
35. Song X, Chen X, Yamaguchi H, Mouneimne G, Condeelis JS, Eddy RJ. Initiation of cofilin activity in response to EGF is uncoupled from cofilin phosphorylation and dephosphorylation in carcinoma cells. J Cell Sci 2006; 119:2871-81.
36. Foster DB, Shen LH, Kelly J, Thibault P, Van Eyk JE, Mak AS. Phosphorylation of Caldesmon by p21-activated Kinase. Implications for the Ca(2+) sensitivity of smooth muscle contraction. J Biol Chem 2000; 275:1959-65.
37. Webb BA, Zhou S, Eves R, Shen L, Jia L, Mak AS. Phosphorylation of cortactin by p21-activated kinase. Arch Biochem Biophys 2006; 456:183-93.
38. Manser E, Loo TH, Koh CG, et al. PAK kinases are directly coupled to the PIX family of nucleotide exchange factors. Mol Cell 1998; 1:183-92.
39. Oikawa T, Itoh T, Takenawa T. Sequential signals toward podosome formation in NIH-src cells. J Cell Biol 2008; 182:157-69.