-
1
-
-
33947593200
-
-
American Cancer Society, American Cancer Society, Atlanta, GA
-
Cancer Facts and Figures 2007 2007, American Cancer Society, American Cancer Society, Atlanta, GA.
-
(2007)
Cancer Facts and Figures 2007
-
-
-
2
-
-
0037050352
-
Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer
-
Schiller JH, Harrington D, Belani CP, et al. Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer. N Engl J Med 2002, 346:92-98.
-
(2002)
N Engl J Med
, vol.346
, pp. 92-98
-
-
Schiller, J.H.1
Harrington, D.2
Belani, C.P.3
-
3
-
-
69349104224
-
WHO histological classification of tumours of the lung
-
World Health Organization, IARC Press, Lyon, France, W.B. Travis, A. Brambilla, H.K. Muller-Hermelinck, C.C. Harris (Eds.)
-
WHO histological classification of tumours of the lung. World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart 2004, 10. World Health Organization, IARC Press, Lyon, France. W.B. Travis, A. Brambilla, H.K. Muller-Hermelinck, C.C. Harris (Eds.).
-
(2004)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart
, pp. 10
-
-
-
4
-
-
49049089802
-
Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer
-
Scagliotti GV, Parikh P, von Pawel J, et al. Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naive patients with advanced-stage non-small-cell lung cancer. J Clin Oncol 2008, 26:3543-3551.
-
(2008)
J Clin Oncol
, vol.26
, pp. 3543-3551
-
-
Scagliotti, G.V.1
Parikh, P.2
von Pawel, J.3
-
5
-
-
0037025173
-
Cancer. Addiction to oncogenes-the Achilles heal of cancer
-
Weinstein IB Cancer. Addiction to oncogenes-the Achilles heal of cancer. Science 2002, 297:63-64.
-
(2002)
Science
, vol.297
, pp. 63-64
-
-
Weinstein, I.B.1
-
6
-
-
0035893318
-
Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes
-
Fisher GH, Wellen SL, Klimstra D, et al. Induction and apoptotic regression of lung adenocarcinomas by regulation of a K-Ras transgene in the presence and absence of tumor suppressor genes. Genes Dev 2001, 15:3249-3262.
-
(2001)
Genes Dev
, vol.15
, pp. 3249-3262
-
-
Fisher, G.H.1
Wellen, S.L.2
Klimstra, D.3
-
7
-
-
33846187218
-
Update on epidermal growth factor receptor mutations in non-small cell lung cancer
-
Riely GJ, Politi KA, Miller VA, Pao W Update on epidermal growth factor receptor mutations in non-small cell lung cancer. Clin Cancer Res 2006, 12:7232-7241.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 7232-7241
-
-
Riely, G.J.1
Politi, K.A.2
Miller, V.A.3
Pao, W.4
-
8
-
-
70349720358
-
Biomarker analyses from a phase III, randomized, open-label, first-line study of gefitinib (G) versus carboplatin/paclitaxel (C/P) in clinically selected patients (pts) with advanced non-small cell lung cancer (NSCLC) in Asia (IPASS)
-
15s (abstr 8006).
-
Fukuoka M, Wu Y, Thongprasert S, et al. Biomarker analyses from a phase III, randomized, open-label, first-line study of gefitinib (G) versus carboplatin/paclitaxel (C/P) in clinically selected patients (pts) with advanced non-small cell lung cancer (NSCLC) in Asia (IPASS). J Clin Oncol 2009, 2:7. 15s (abstr 8006).
-
(2009)
J Clin Oncol
, vol.2
, pp. 7
-
-
Fukuoka, M.1
Wu, Y.2
Thongprasert, S.3
-
9
-
-
75249087060
-
Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial
-
Mitsudomi T, Morita S, Yatabe Y, et al. Gefitinib versus cisplatin plus docetaxel in patients with non-small-cell lung cancer harbouring mutations of the epidermal growth factor receptor (WJTOG3405): an open label, randomised phase 3 trial. Lancet Oncol 2010, 11:121-128.
-
(2010)
Lancet Oncol
, vol.11
, pp. 121-128
-
-
Mitsudomi, T.1
Morita, S.2
Yatabe, Y.3
-
10
-
-
36248980204
-
Characterizing the cancer genome in lung adenocarcinoma
-
Weir BA, Woo MS, Getz G, et al. Characterizing the cancer genome in lung adenocarcinoma. Nature 2007, 450:893-898.
-
(2007)
Nature
, vol.450
, pp. 893-898
-
-
Weir, B.A.1
Woo, M.S.2
Getz, G.3
-
11
-
-
46249096082
-
Lung adenocarcinoma: modification of the 2004 WHO mixed subtype to include the major histologic subtype suggests correlations between papillary and micropapillary adenocarcinoma subtypes, EGFR mutations and gene expression analysis
-
Motoi N, Szoke J, Riely GJ, et al. Lung adenocarcinoma: modification of the 2004 WHO mixed subtype to include the major histologic subtype suggests correlations between papillary and micropapillary adenocarcinoma subtypes, EGFR mutations and gene expression analysis. Am J Surg Pathol 2008, 32:810-827.
-
(2008)
Am J Surg Pathol
, vol.32
, pp. 810-827
-
-
Motoi, N.1
Szoke, J.2
Riely, G.J.3
-
12
-
-
54549094903
-
Somatic mutations affect key pathways in lung adenocarcinoma
-
Ding L, Getz G, Wheeler DA, et al. Somatic mutations affect key pathways in lung adenocarcinoma. Nature 2008, 455:1069-1075.
-
(2008)
Nature
, vol.455
, pp. 1069-1075
-
-
Ding, L.1
Getz, G.2
Wheeler, D.A.3
-
13
-
-
36849065315
-
Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer
-
Rikova K, Guo A, Zeng Q, et al. Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. Cell 2007, 131:1190-1203.
-
(2007)
Cell
, vol.131
, pp. 1190-1203
-
-
Rikova, K.1
Guo, A.2
Zeng, Q.3
-
14
-
-
0031008896
-
ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)
-
Morris SW, Naeve C, Mathew P, et al. ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK). Oncogene 1997, 14:2175-2188.
-
(1997)
Oncogene
, vol.14
, pp. 2175-2188
-
-
Morris, S.W.1
Naeve, C.2
Mathew, P.3
-
15
-
-
0029648292
-
Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma
-
Morris SW, Kirstein MN, Valentine MB, et al. Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma. Science 1995, 267:316-317.
-
(1995)
Science
, vol.267
, pp. 316-317
-
-
Morris, S.W.1
Kirstein, M.N.2
Valentine, M.B.3
-
16
-
-
34547638047
-
Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer
-
Soda M, Choi YL, Enomoto M, et al. Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer. Nature 2007, 448:561-566.
-
(2007)
Nature
, vol.448
, pp. 561-566
-
-
Soda, M.1
Choi, Y.L.2
Enomoto, M.3
-
17
-
-
48549098388
-
Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer
-
Choi YL, Takeuchi K, Soda M, et al. Identification of novel isoforms of the EML4-ALK transforming gene in non-small cell lung cancer. Cancer Res 2008, 68:4971-4976.
-
(2008)
Cancer Res
, vol.68
, pp. 4971-4976
-
-
Choi, Y.L.1
Takeuchi, K.2
Soda, M.3
-
18
-
-
48249114422
-
EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer
-
Koivunen JP, Mermel C, Zejnullahu K, et al. EML4-ALK fusion gene and efficacy of an ALK kinase inhibitor in lung cancer. Clin Cancer Res 2008, 14:4275-4283.
-
(2008)
Clin Cancer Res
, vol.14
, pp. 4275-4283
-
-
Koivunen, J.P.1
Mermel, C.2
Zejnullahu, K.3
-
19
-
-
70349342712
-
EML4-ALK: honing in on a new target in non-small-cell lung cancer
-
Horn L, Pao W EML4-ALK: honing in on a new target in non-small-cell lung cancer. J Clin Oncol 2009, 27:4247-4253.
-
(2009)
J Clin Oncol
, vol.27
, pp. 4247-4253
-
-
Horn, L.1
Pao, W.2
-
20
-
-
0001044842
-
Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein
-
Daley GQ, Baltimore D Transformation of an interleukin 3-dependent hematopoietic cell line by the chronic myelogenous leukemia-specific P210bcr/abl protein. Proc Natl Acad Sci USA 1988, 85:9312-9316.
-
(1988)
Proc Natl Acad Sci USA
, vol.85
, pp. 9312-9316
-
-
Daley, G.Q.1
Baltimore, D.2
-
21
-
-
58149382583
-
A mouse model for EML4-ALK-positive lung cancer
-
Soda M, Takada S, Takeuchi K, et al. A mouse model for EML4-ALK-positive lung cancer. Proc Natl Acad Sci USA 2008, 105:19893-19897.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 19893-19897
-
-
Soda, M.1
Takada, S.2
Takeuchi, K.3
-
22
-
-
77955174967
-
Clinical activity of the oral ALK inhibitor PF-02341066 in ALK-positive patients with non-small cell cancer (NSCLC)
-
(abstr 3).
-
Bang Y, Kwak EL, Shaw AT, et al. Clinical activity of the oral ALK inhibitor PF-02341066 in ALK-positive patients with non-small cell cancer (NSCLC). J Clin Oncol 2010, 28:18s. (abstr 3).
-
(2010)
J Clin Oncol
, vol.28
-
-
Bang, Y.1
Kwak, E.L.2
Shaw, A.T.3
-
23
-
-
33745727112
-
HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and ressitance to EGFR tyrosine kinase inhibitors
-
Wang SE, Narasanna A, Perez-Torres M, et al. HER2 kinase domain mutation results in constitutive phosphorylation and activation of HER2 and EGFR and ressitance to EGFR tyrosine kinase inhibitors. Cancer Cell 2006, 10:25-38.
-
(2006)
Cancer Cell
, vol.10
, pp. 25-38
-
-
Wang, S.E.1
Narasanna, A.2
Perez-Torres, M.3
-
24
-
-
78649998667
-
Clinical activity of BIBW2992, an irreversible inhibitor of EGFR and HER2 in adenocarcinoma of the lung with mutations in the kinase domain of HER2neu
-
(abstr).
-
De Greve J, Teugels E, De Mey J, et al. Clinical activity of BIBW2992, an irreversible inhibitor of EGFR and HER2 in adenocarcinoma of the lung with mutations in the kinase domain of HER2neu. J Thorac Oncol 2009, 4:S307. (abstr).
-
(2009)
J Thorac Oncol
, vol.4
-
-
De Greve, J.1
Teugels, E.2
De Mey, J.3
-
25
-
-
1242341493
-
The role of HER2/neu expression and trastuzumab in non-small cell lung cancer
-
Hirsch FR, Langer CJ The role of HER2/neu expression and trastuzumab in non-small cell lung cancer. Semin Oncol 2004, 31:75-82.
-
(2004)
Semin Oncol
, vol.31
, pp. 75-82
-
-
Hirsch, F.R.1
Langer, C.J.2
-
26
-
-
76749171098
-
Phase I dose-escalation study of XL147, a PI3K inhibitor administered orally to patients with solid tumors
-
(abstr 3500).
-
Shapiro G, Kwak E, Baselga J, et al. Phase I dose-escalation study of XL147, a PI3K inhibitor administered orally to patients with solid tumors. J Clin Oncol 2009, 27:15s. (abstr 3500).
-
(2009)
J Clin Oncol
, vol.27
-
-
Shapiro, G.1
Kwak, E.2
Baselga, J.3
-
27
-
-
34547469939
-
Raf kinases: function, regulation and role in human cancer
-
Leicht DT, Balan V, Kaplun A, et al. Raf kinases: function, regulation and role in human cancer. Biochim Biophys Acta 2007, 1773:1196-1212.
-
(2007)
Biochim Biophys Acta
, vol.1773
, pp. 1196-1212
-
-
Leicht, D.T.1
Balan, V.2
Kaplun, A.3
-
28
-
-
63549123584
-
Carboplatin/paclitaxel with/without sorafenib in chemonaive patients with stage iiib-iv non-small cell lung cancer: interim analysis (ia) results from a randomized phase III trial (ESCAPE)
-
(abstr 214).
-
Hanna NH, Pawel Jv, Reck M, Scagliotti G Carboplatin/paclitaxel with/without sorafenib in chemonaive patients with stage iiib-iv non-small cell lung cancer: interim analysis (ia) results from a randomized phase III trial (ESCAPE). J Thorac Oncol 2008, 3(suppl 7):S268. (abstr 214).
-
(2008)
J Thorac Oncol
, vol.3
, Issue.SUPPL. 7
-
-
Hanna, N.H.1
Pawel, J.2
Reck, M.3
Scagliotti, G.4
-
30
-
-
0022399581
-
Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene
-
Coussens L, Yang-Feng TL, Liao YC, et al. Tyrosine kinase receptor with extensive homology to EGF receptor shares chromosomal location with neu oncogene. Science 1985, 230:1132-1139.
-
(1985)
Science
, vol.230
, pp. 1132-1139
-
-
Coussens, L.1
Yang-Feng, T.L.2
Liao, Y.C.3
-
31
-
-
0242442020
-
HER2 status in non-small cell lung cancer: results from patient screening for enrollment to a phase II study of herceptin
-
Heinmöller P, Gross C, Beyser K, et al. HER2 status in non-small cell lung cancer: results from patient screening for enrollment to a phase II study of herceptin. Clin Cancer Res 2003, 9:5238-5243.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 5238-5243
-
-
Heinmöller, P.1
Gross, C.2
Beyser, K.3
-
32
-
-
4944232647
-
Lung cancer: intragenic ERBB2 kinase mutations in tumours
-
Stephens P, Hunter C, Bignell G, et al. Lung cancer: intragenic ERBB2 kinase mutations in tumours. Nature 2004, 431:525-526.
-
(2004)
Nature
, vol.431
, pp. 525-526
-
-
Stephens, P.1
Hunter, C.2
Bignell, G.3
-
33
-
-
20144386787
-
Somatic mutations of the HER2 kinase domain in lung adenocarcinomas
-
Shigematsu H, Takahashi T, Nomura M, et al. Somatic mutations of the HER2 kinase domain in lung adenocarcinomas. Cancer Res 2005, 65:1642-1646.
-
(2005)
Cancer Res
, vol.65
, pp. 1642-1646
-
-
Shigematsu, H.1
Takahashi, T.2
Nomura, M.3
-
34
-
-
33750627353
-
Mutational analysis of the HER2 gene in lung tumors from Caucasian patients: mutations are mainly present in adenocarcinomas with bronchioloalveolar features
-
Buttitta F, Barassi F, Fresu G, et al. Mutational analysis of the HER2 gene in lung tumors from Caucasian patients: mutations are mainly present in adenocarcinomas with bronchioloalveolar features. Int J Cancer 2006, 119:2586-2591.
-
(2006)
Int J Cancer
, vol.119
, pp. 2586-2591
-
-
Buttitta, F.1
Barassi, F.2
Fresu, G.3
-
35
-
-
33746154236
-
Non-small-cell lung cancer and Ba/F3 transformed cells harboring the ERBB2 G776insV_G/C mutation are sensitive to the dual-specific epidermal growth factor receptor and ERBB2 inhibitor HKI-272
-
Shimamura T, Ji H, Minami Y, et al. Non-small-cell lung cancer and Ba/F3 transformed cells harboring the ERBB2 G776insV_G/C mutation are sensitive to the dual-specific epidermal growth factor receptor and ERBB2 inhibitor HKI-272. Cancer Res 2006, 66:6487-6491.
-
(2006)
Cancer Res
, vol.66
, pp. 6487-6491
-
-
Shimamura, T.1
Ji, H.2
Minami, Y.3
-
36
-
-
58849132314
-
HER2YVMA drives rapid development of adenosquamous lung tumors in mice that are sensitive to BIBW2992 and rapamycin combination therapy
-
Perera SA, Li D, Shimamura T, et al. HER2YVMA drives rapid development of adenosquamous lung tumors in mice that are sensitive to BIBW2992 and rapamycin combination therapy. Proc Natl Acad Sci USA 2009, 106:474-479.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 474-479
-
-
Perera, S.A.1
Li, D.2
Shimamura, T.3
-
37
-
-
33745057881
-
HER2 mutation and response to trastuzumab therapy in non-small-cell lung cancer
-
Cappuzzo F, Bemis L, Varella-Garcia M HER2 mutation and response to trastuzumab therapy in non-small-cell lung cancer. N Engl J Med 2006, 354:2619-2621.
-
(2006)
N Engl J Med
, vol.354
, pp. 2619-2621
-
-
Cappuzzo, F.1
Bemis, L.2
Varella-Garcia, M.3
-
38
-
-
0032472913
-
Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase
-
Jimenez C, Jones DR, Rodríguez-Viciana P, et al. Identification and characterization of a new oncogene derived from the regulatory subunit of phosphoinositide 3-kinase. EMBO J 1998, 17:743-753.
-
(1998)
EMBO J
, vol.17
, pp. 743-753
-
-
Jimenez, C.1
Jones, D.R.2
Rodríguez-Viciana, P.3
-
39
-
-
11144358645
-
High frequency of mutations of the PIK3CA gene in human cancers
-
Samuels Y, Wang Z, Bardelli A, et al. High frequency of mutations of the PIK3CA gene in human cancers. Science 2004, 304:554.
-
(2004)
Science
, vol.304
, pp. 554
-
-
Samuels, Y.1
Wang, Z.2
Bardelli, A.3
-
40
-
-
33751084640
-
PIK3CA mutation status in Japanese lung cancer patients
-
Kawano O, Sasaki H, Endo K, et al. PIK3CA mutation status in Japanese lung cancer patients. Lung Cancer 2006, 54:209-215.
-
(2006)
Lung Cancer
, vol.54
, pp. 209-215
-
-
Kawano, O.1
Sasaki, H.2
Endo, K.3
-
41
-
-
34548446446
-
PIK3CA mutation and amplification in human lung cancer
-
Okudela K, Suzuki M, Kageyama S, et al. PIK3CA mutation and amplification in human lung cancer. Pathol Int 2007, 57:664-671.
-
(2007)
Pathol Int
, vol.57
, pp. 664-671
-
-
Okudela, K.1
Suzuki, M.2
Kageyama, S.3
-
42
-
-
21144457217
-
Functional analysis of PIK3CA gene mutations in human colorectal cancer
-
Ikenoue T, Kanai F, Hikiba Y, et al. Functional analysis of PIK3CA gene mutations in human colorectal cancer. Cancer Res 2005, 65:4562-4567.
-
(2005)
Cancer Res
, vol.65
, pp. 4562-4567
-
-
Ikenoue, T.1
Kanai, F.2
Hikiba, Y.3
-
43
-
-
14144252004
-
Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic
-
Kang S, Bader AG, Vogt PK Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic. Proc Natl Acad Sci USA 2005, 102:802-807.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 802-807
-
-
Kang, S.1
Bader, A.G.2
Vogt, P.K.3
-
44
-
-
34548485621
-
PIK3CA gene amplification in Japanese non-small cell lung cancer
-
Kawano O, Sasaki H, Okuda K, et al. PIK3CA gene amplification in Japanese non-small cell lung cancer. Lung Cancer 2007, 58:159-160.
-
(2007)
Lung Cancer
, vol.58
, pp. 159-160
-
-
Kawano, O.1
Sasaki, H.2
Okuda, K.3
-
45
-
-
38949101107
-
Expression signatures in lung cancer reveal a profile for EGFR-mutant tumours and identify selective PIK3CA overexpression by gene amplification
-
Angulo B, Suarez-Gauthier A, Lopez-Rios F, et al. Expression signatures in lung cancer reveal a profile for EGFR-mutant tumours and identify selective PIK3CA overexpression by gene amplification. J Pathol 2008, 214:347-356.
-
(2008)
J Pathol
, vol.214
, pp. 347-356
-
-
Angulo, B.1
Suarez-Gauthier, A.2
Lopez-Rios, F.3
-
46
-
-
57349194139
-
Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers
-
Engelman JA, Chen L, Tan X, et al. Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers. Nat Med 2008, 14:1351-1356.
-
(2008)
Nat Med
, vol.14
, pp. 1351-1356
-
-
Engelman, J.A.1
Chen, L.2
Tan, X.3
-
47
-
-
0035949699
-
AKT plays a central role in tumorigenesis
-
Testa JR, Bellacosa A AKT plays a central role in tumorigenesis. Proc Natl Acad Sci USA 2001, 98:10983-10985.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 10983-10985
-
-
Testa, J.R.1
Bellacosa, A.2
-
48
-
-
34547172596
-
A transforming mutation in the pleckstrin homology domain of AKT1 in cancer
-
Carpten JD, Faber AL, Horn C, et al. A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. Nature 2007, 448:439-444.
-
(2007)
Nature
, vol.448
, pp. 439-444
-
-
Carpten, J.D.1
Faber, A.L.2
Horn, C.3
-
49
-
-
41849132829
-
Activating E17K mutation in the gene encoding the protein kinase AKT1 in a subset of squamous cell carcinoma of the lung
-
Malanga D, Scrima M, De Marco C, et al. Activating E17K mutation in the gene encoding the protein kinase AKT1 in a subset of squamous cell carcinoma of the lung. Cell Cycle 2008, 7:665-669.
-
(2008)
Cell Cycle
, vol.7
, pp. 665-669
-
-
Malanga, D.1
Scrima, M.2
De Marco, C.3
-
50
-
-
68049132168
-
A phase I study of MK-2206, an oral potent allosteric Akt inhibitor (Akti), in patients (pts) with advanced solid tumor (ST)
-
(abstr 3503).
-
Tolcher AW, Yap TA, Fearen I, et al. A phase I study of MK-2206, an oral potent allosteric Akt inhibitor (Akti), in patients (pts) with advanced solid tumor (ST). Proc Am Soc Clin Oncol 2009, 27:15s. (abstr 3503).
-
(2009)
Proc Am Soc Clin Oncol
, vol.27
-
-
Tolcher, A.W.1
Yap, T.A.2
Fearen, I.3
-
51
-
-
18444374405
-
Mutations of the BRAF gene in human cancer
-
Davies H, Bignell GR, Cox C, et al. Mutations of the BRAF gene in human cancer. Nature 2002, 417:949-954.
-
(2002)
Nature
, vol.417
, pp. 949-954
-
-
Davies, H.1
Bignell, G.R.2
Cox, C.3
-
52
-
-
33646791858
-
Uncommon V599E BRAF mutations in Japanese patients with lung cancer
-
Sasaki H, Kawano O, Endo K, et al. Uncommon V599E BRAF mutations in Japanese patients with lung cancer. J Surg Res 2006, 133:203-206.
-
(2006)
J Surg Res
, vol.133
, pp. 203-206
-
-
Sasaki, H.1
Kawano, O.2
Endo, K.3
-
53
-
-
0036895599
-
Missense mutations of the BRAF gene in human lung adenocarcinoma
-
Naoki K, Chen TH, Richards WG, Sugarbaker DJ, Meyerson M Missense mutations of the BRAF gene in human lung adenocarcinoma. Cancer Res 2002, 62:7001-7003.
-
(2002)
Cancer Res
, vol.62
, pp. 7001-7003
-
-
Naoki, K.1
Chen, T.H.2
Richards, W.G.3
Sugarbaker, D.J.4
Meyerson, M.5
-
54
-
-
34250340783
-
Mutations in BRAF and KRAS converge on activation of the mitogen-activated protein kinase pathway in lung cancer mouse models
-
Ji H, Wang Z, Perera SA, et al. Mutations in BRAF and KRAS converge on activation of the mitogen-activated protein kinase pathway in lung cancer mouse models. Cancer Res 2007, 67:4933-4939.
-
(2007)
Cancer Res
, vol.67
, pp. 4933-4939
-
-
Ji, H.1
Wang, Z.2
Perera, S.A.3
-
55
-
-
42949149240
-
Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity
-
Tsai J, Lee JT, Wang W, et al. Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity. Proc Natl Acad Sci USA 2008, 105:3041-3046.
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 3041-3046
-
-
Tsai, J.1
Lee, J.T.2
Wang, W.3
-
56
-
-
31144453233
-
BRAF mutation predicts sensitivity to MEK inhibition
-
Solit DB, Garraway LA, Pratilas CA, et al. BRAF mutation predicts sensitivity to MEK inhibition. Nature 2006, 439:358-362.
-
(2006)
Nature
, vol.439
, pp. 358-362
-
-
Solit, D.B.1
Garraway, L.A.2
Pratilas, C.A.3
-
57
-
-
0026754369
-
Activation of the MAP kinase pathway by the protein kinase raf
-
Howe LR, Leevers SJ, Gómez N, Nakielny S, Cohen P, Marshall CJ Activation of the MAP kinase pathway by the protein kinase raf. Cell 1992, 71:335-342.
-
(1992)
Cell
, vol.71
, pp. 335-342
-
-
Howe, L.R.1
Leevers, S.J.2
Gómez, N.3
Nakielny, S.4
Cohen, P.5
Marshall, C.J.6
-
58
-
-
48649107410
-
Novel MEK1 mutation identified by mutational analysis of epidermal growth factor receptor signaling pathway genes in lung adenocarcinoma
-
Marks JL, Gong Y, Chitale D, et al. Novel MEK1 mutation identified by mutational analysis of epidermal growth factor receptor signaling pathway genes in lung adenocarcinoma. Cancer Res 2008, 68:5524-5528.
-
(2008)
Cancer Res
, vol.68
, pp. 5524-5528
-
-
Marks, J.L.1
Gong, Y.2
Chitale, D.3
-
59
-
-
65649152804
-
Efficacy and safety of AZD6244 (ARRY-142886) as second/third-line treatment of patients (pts) with advanced non-small cell lung cancer (NSCLC)
-
(abstr 8029).
-
Tzekova V, Cebotaru C, Ciuleanu TE, et al. Efficacy and safety of AZD6244 (ARRY-142886) as second/third-line treatment of patients (pts) with advanced non-small cell lung cancer (NSCLC). J Clin Oncol 2008, 26:15s. (abstr 8029).
-
(2008)
J Clin Oncol
, vol.26
-
-
Tzekova, V.1
Cebotaru, C.2
Ciuleanu, T.E.3
-
60
-
-
0025862023
-
Organization of the human hepatocyte growth factor-encoding gene
-
Seki T, Hagiya M, Shimonishi M, Nakamura T, Shimizu S Organization of the human hepatocyte growth factor-encoding gene. Gene 1991, 102:213-219.
-
(1991)
Gene
, vol.102
, pp. 213-219
-
-
Seki, T.1
Hagiya, M.2
Shimonishi, M.3
Nakamura, T.4
Shimizu, S.5
-
61
-
-
38049150665
-
MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib
-
Bean J, Brennan C, Shih JY, et al. MET amplification occurs with or without T790M mutations in EGFR mutant lung tumors with acquired resistance to gefitinib or erlotinib. Proc Natl Acad Sci USA 2007, 104:20932-20937.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 20932-20937
-
-
Bean, J.1
Brennan, C.2
Shih, J.Y.3
-
62
-
-
34249075147
-
MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
-
Engelman JA, Zejnullahu K, Mitsudomi T, et al. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science 2007, 316:1039-1043.
-
(2007)
Science
, vol.316
, pp. 1039-1043
-
-
Engelman, J.A.1
Zejnullahu, K.2
Mitsudomi, T.3
-
63
-
-
61549138135
-
Activation of MET by gene amplification or by splice mutations deleting the juxtamembrane domain in primary resected lung cancers
-
Onozato R, Kosaka T, Kuwano H, Sekido Y, Yatabe Y, Mitsudomi T Activation of MET by gene amplification or by splice mutations deleting the juxtamembrane domain in primary resected lung cancers. J Thorac Oncol 2009, 4:5-11.
-
(2009)
J Thorac Oncol
, vol.4
, pp. 5-11
-
-
Onozato, R.1
Kosaka, T.2
Kuwano, H.3
Sekido, Y.4
Yatabe, Y.5
Mitsudomi, T.6
-
64
-
-
41749097250
-
MET gene copy number in non-small cell lung cancer: molecular analysis in a targeted tyrosine kinase inhibitor naïve cohort
-
Beau-Faller M, Ruppert AM, Voegeli AC, et al. MET gene copy number in non-small cell lung cancer: molecular analysis in a targeted tyrosine kinase inhibitor naïve cohort. J Thorac Oncol 2008, 3:331-339.
-
(2008)
J Thorac Oncol
, vol.3
, pp. 331-339
-
-
Beau-Faller, M.1
Ruppert, A.M.2
Voegeli, A.C.3
-
65
-
-
63849163410
-
Increased MET gene copy number negatively affects survival of surgically resected non-small-cell lung cancer patients
-
Cappuzzo F, Marchetti A, Skokan M, et al. Increased MET gene copy number negatively affects survival of surgically resected non-small-cell lung cancer patients. J Clin Oncol 2009, 27:1667-1674.
-
(2009)
J Clin Oncol
, vol.27
, pp. 1667-1674
-
-
Cappuzzo, F.1
Marchetti, A.2
Skokan, M.3
-
66
-
-
0032533495
-
C-Met autocrine activation induces development of malignant melanoma and acquisition of the metastatic phenotype
-
Otsuka T, Takayama H, Sharp R, et al. c-Met autocrine activation induces development of malignant melanoma and acquisition of the metastatic phenotype. Cancer Res 1998, 58:5157-5167.
-
(1998)
Cancer Res
, vol.58
, pp. 5157-5167
-
-
Otsuka, T.1
Takayama, H.2
Sharp, R.3
-
67
-
-
33947207989
-
Lung cancer cell lines harboring MET gene amplification are dependent on Met for growth and survival
-
Lutterbach B, Zeng Q, Davis LJ, et al. Lung cancer cell lines harboring MET gene amplification are dependent on Met for growth and survival. Cancer Res 2007, 67:2081-2088.
-
(2007)
Cancer Res
, vol.67
, pp. 2081-2088
-
-
Lutterbach, B.1
Zeng, Q.2
Davis, L.J.3
-
68
-
-
31544462584
-
Somatic mutations lead to an oncogenic deletion of met in lung cancer
-
Kong-Beltran M, Seshagiri S, Zha J, et al. Somatic mutations lead to an oncogenic deletion of met in lung cancer. Cancer Res 2006, 66:283-289.
-
(2006)
Cancer Res
, vol.66
, pp. 283-289
-
-
Kong-Beltran, M.1
Seshagiri, S.2
Zha, J.3
-
69
-
-
65249122512
-
Novel therapeutic inhibitors of the c-Met signaling pathway in cancer
-
Eder JP, Vande Woude GF, Boerner SA, LoRusso PM Novel therapeutic inhibitors of the c-Met signaling pathway in cancer. Clin Cancer Res 2009, 15:2207-2214.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 2207-2214
-
-
Eder, J.P.1
Vande Woude, G.F.2
Boerner, S.A.3
LoRusso, P.M.4
-
70
-
-
69949102185
-
Integration of molecular profiling into the lung cancer clinic
-
Pao W, Kris MG, Iafrate AJ, et al. Integration of molecular profiling into the lung cancer clinic. Clin Cancer Res 2009, 15:5317-5322.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 5317-5322
-
-
Pao, W.1
Kris, M.G.2
Iafrate, A.J.3
-
71
-
-
33845490014
-
Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer
-
Sandler A, Gray R, Perry MC, et al. Paclitaxel-carboplatin alone or with bevacizumab for non-small-cell lung cancer. N Engl J Med 2006, 355:2542-2550.
-
(2006)
N Engl J Med
, vol.355
, pp. 2542-2550
-
-
Sandler, A.1
Gray, R.2
Perry, M.C.3
-
72
-
-
70350218696
-
High expression levels of total IGF-1R and sensitivity of NSCLC cells in vitro to an anti-IGF-1R antibody (R1507)
-
Gong Y, Yao E, Shen R, et al. High expression levels of total IGF-1R and sensitivity of NSCLC cells in vitro to an anti-IGF-1R antibody (R1507). PLoS One 2009, 4:e7273.
-
(2009)
PLoS One
, vol.4
-
-
Gong, Y.1
Yao, E.2
Shen, R.3
-
73
-
-
24744453982
-
Somatic mutations of the protein kinase gene family in human lung cancer
-
Davies H, Hunter C, Smith R, et al. Somatic mutations of the protein kinase gene family in human lung cancer. Cancer Res 2005, 65:7591-7595.
-
(2005)
Cancer Res
, vol.65
, pp. 7591-7595
-
-
Davies, H.1
Hunter, C.2
Smith, R.3
-
75
-
-
77950261074
-
Transcriptional pathway signatures predict mek addiction and response to selumetinib (AZD6244)
-
Dry JR, Pavey S, Pratilas CA, et al. Transcriptional pathway signatures predict mek addiction and response to selumetinib (AZD6244). Cancer Res 2010, 70:2264-2273.
-
(2010)
Cancer Res
, vol.70
, pp. 2264-2273
-
-
Dry, J.R.1
Pavey, S.2
Pratilas, C.A.3
|