The mammalian MAPK/ERK pathway exhibits properties of a negative feedback amplifier

Science Signaling

Volumn 3, Issue 153, 2010, Pages

  Sturm, Oliver E ^a,d   Orton, Richard ^a   Grindlay, Joan ^b   Birtwistle, Marc ^c   Vyshemirsky, Vladislav ^a,e   Gilbert, David ^a,f   Calder, Muffy ^a   Pitt, Andrew ^a   Kholodenko, Boris ^c   Kolch, Walter ^c  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b BEATSON INSTITUTE FOR CANCER RESEARCH   (United Kingdom)

^c UNIVERSITY COLLEGE DUBLIN   (Ireland)

^d ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^e UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^f BRUNEL UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; RAF PROTEIN; 1,3 BUTADIENE DERIVATIVE; 1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4557 W; D 64406; D-64406; GUANINE NUCLEOTIDE EXCHANGE FACTOR; GUANOSINE TRIPHOSPHATE; INDOLE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE; NITRILE; QUINAZOLINE DERIVATIVE; RAS PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; INTEGRATED CIRCUIT; MOUSE; NEGATIVE FEEDBACK; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; ANIMAL; CELL MEMBRANE; CELL STRAIN 3T3; FEEDBACK SYSTEM; FLOW CYTOMETRY; IMMUNOBLOTTING; IMMUNOPRECIPITATION; KINETICS; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; SIGNAL TRANSDUCTION; THEORETICAL MODEL;

MAMMALIA;

ANIMALS; BUTADIENES; CELL MEMBRANE; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEEDBACK, PHYSIOLOGICAL; FLOW CYTOMETRY; GUANINE NUCLEOTIDE EXCHANGE FACTORS; GUANOSINE TRIPHOSPHATE; IMMUNOBLOTTING; IMMUNOPRECIPITATION; INDOLES; KINETICS; MAP KINASE KINASE KINASES; METABOLIC NETWORKS AND PATHWAYS; MICE; MODELS, THEORETICAL; NIH 3T3 CELLS; NITRILES; PHOSPHORYLATION; QUINAZOLINES; RAS PROTEINS; SIGNAL TRANSDUCTION;

EID: 78650635354     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2001212     Document Type: Article

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33. Acknowledgments: We thank T. Gilbey for help with the FACS analysis and J. Kamburapola for help with the LI-COR gels. Funding: This work was supported by a DTI Beacons Project, Cancer Research UK, Engineering and Physical Sciences Research Council Basic Technology research grant EP/E032745/1, Science Foundation Ireland grant no. 06/CE/B1129, and FP7 Marie Curie fellowship no. 236758 to M.B. Author contributions: O.E.S., J.G., and A.P. performed the experiments; R.O., V.V., and M.B. did the mathematical modeling; W.K., B.K., M.C., and D.G. designed the study; and W.K., R.O., and M.B. wrote the manuscript. Competing interests: The authors declare that they have no competing interests.