메뉴 건너뛰기




Volumn 99, Issue 2, 2008, Pages 209-213

Portrait of PTEN: Messages from mutant mice

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; ACYL COENZYME A DESATURASE; ACYL COENZYME A OXIDASE; ANDROGEN RECEPTOR; ANGIOPOIETIN 1; ANGIOPOIETIN 2; CONNEXIN 40; EPHRIN B2; EPIDERMAL GROWTH FACTOR RECEPTOR; ESTROGEN RECEPTOR ALPHA; FATTY ACID SYNTHASE; FIBROBLAST GROWTH FACTOR RECEPTOR 3; FOCAL ADHESION KINASE; K RAS PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN BCL XL; PROTEIN KINASE B; PROTEIN SHC; RAD51 PROTEIN; RAS PROTEIN; SOS PROTEIN; TRANSCRIPTION FACTOR FKHR; VASCULAR CELL ADHESION MOLECULE 1; VASCULOTROPIN A; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2;

EID: 39049101676     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2007.00670.x     Document Type: Review
Times cited : (88)

References (72)
  • 1
    • 0030992837 scopus 로고    scopus 로고
    • Signalling through the lipid products of phosphoinositide-3-OH kinase
    • Toker A, Cantley LC. Signalling through the lipid products of phosphoinositide-3-OH kinase. Nature 1997; 387: 673-6.
    • (1997) Nature , vol.387 , pp. 673-676
    • Toker, A.1    Cantley, L.C.2
  • 2
    • 0030936323 scopus 로고    scopus 로고
    • PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
    • Li J, Yen C, Liaw D et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 1997; 275: 1943-7.
    • (1997) Science , vol.275 , pp. 1943-1947
    • Li, J.1    Yen, C.2    Liaw, D.3
  • 3
    • 0028827104 scopus 로고
    • Multiple essential functions of neuregulin in development
    • Meyer D, Birchmeier C. Multiple essential functions of neuregulin in development. Nature 1995; 378: 386-90.
    • (1995) Nature , vol.378 , pp. 386-390
    • Meyer, D.1    Birchmeier, C.2
  • 4
    • 0032577699 scopus 로고    scopus 로고
    • The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
    • Maehama T, Dixon JE. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J Biol Chem 1998; 273: 13.375-8.
    • (1998) J Biol Chem , vol.273
    • Maehama, T.1    Dixon, J.E.2
  • 5
    • 0032486198 scopus 로고    scopus 로고
    • Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN
    • Tamura M, Gu J, Matsumoto K, Aota S, Parsons R, Yamada KM. Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN. Science 1998; 280: 1614-17.
    • (1998) Science , vol.280 , pp. 1614-1617
    • Tamura, M.1    Gu, J.2    Matsumoto, K.3    Aota, S.4    Parsons, R.5    Yamada, K.M.6
  • 6
    • 0033606767 scopus 로고    scopus 로고
    • Shc and FAK differentially regulate cell motility and directionality modulated by PTEN
    • Gu J, Tamura M, Pankov R et al. Shc and FAK differentially regulate cell motility and directionality modulated by PTEN. J Cell Biol 1999; 146: 389-403.
    • (1999) J Cell Biol , vol.146 , pp. 389-403
    • Gu, J.1    Tamura, M.2    Pankov, R.3
  • 7
    • 2442498583 scopus 로고    scopus 로고
    • Inactivation of platelet-derived growth factor receptor by the tumor suppressor PTEN provides a novel mechanism of action of the phosphatase
    • Mahimainathan L, Choudhury GG. Inactivation of platelet-derived growth factor receptor by the tumor suppressor PTEN provides a novel mechanism of action of the phosphatase. J Biol Chem 2004; 279: 15.258-68.
    • (2004) J Biol Chem , vol.279
    • Mahimainathan, L.1    Choudhury, G.G.2
  • 8
    • 0033119739 scopus 로고    scopus 로고
    • SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival
    • Liu Q, Sasaki T, Kozieradzki I et al. SHIP is a negative regulator of growth factor receptor-mediated PKB/Akt activation and myeloid cell survival. Genes Dev 1999; 13: 786-91.
    • (1999) Genes Dev , vol.13 , pp. 786-791
    • Liu, Q.1    Sasaki, T.2    Kozieradzki, I.3
  • 9
    • 21344475048 scopus 로고    scopus 로고
    • Impact of the liver-specific expression of SHIP2 (SH2-containing inositol 5′-phosphatase 2) on insulin signaling and glucose metabolism in mice
    • Fukui K, Wada T, Kagawa S et al. Impact of the liver-specific expression of SHIP2 (SH2-containing inositol 5′-phosphatase 2) on insulin signaling and glucose metabolism in mice. Diabetes 2005; 54: 1958-67.
    • (2005) Diabetes , vol.54 , pp. 1958-1967
    • Fukui, K.1    Wada, T.2    Kagawa, S.3
  • 11
    • 0031004088 scopus 로고    scopus 로고
    • Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome
    • Liaw D, Marsh DJ, Li J et al. Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome. Nat Genet 1997; 16: 64-7.
    • (1997) Nat Genet , vol.16 , pp. 64-67
    • Liaw, D.1    Marsh, D.J.2    Li, J.3
  • 12
    • 13144249184 scopus 로고    scopus 로고
    • High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice
    • Suzuki A, de la Pompa JL, Stambolic V et al. High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice. Curr Biol 1998; 8: 1169-78.
    • (1998) Curr Biol , vol.8 , pp. 1169-1178
    • Suzuki, A.1    de la Pompa, J.L.2    Stambolic, V.3
  • 13
    • 0032475861 scopus 로고    scopus 로고
    • Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN
    • Stambolic V, Suzuki A, de la Pompa JL et al. Negative regulation of PKB/ Akt-dependent cell survival by the tumor suppressor PTEN. Cell 1998; 95: 29-39.
    • (1998) Cell , vol.95 , pp. 29-39
    • Stambolic, V.1    Suzuki, A.2    de la Pompa, J.L.3
  • 14
    • 0031870959 scopus 로고    scopus 로고
    • Pten is essential for embryonic development and tumour suppression
    • Di Cristofano A, Pesce B, Cordon-Cardo C, Pandolfi PP. Pten is essential for embryonic development and tumour suppression. Nat Genet 1998; 19: 348-55.
    • (1998) Nat Genet , vol.19 , pp. 348-355
    • Di Cristofano, A.1    Pesce, B.2    Cordon-Cardo, C.3    Pandolfi, P.P.4
  • 15
    • 13044250465 scopus 로고    scopus 로고
    • Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems
    • Podsypanina K, Ellenson LH, Nemes A et al. Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems. Proc Natl Acad Sci USA 1999; 96: 1563-8.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 1563-1568
    • Podsypanina, K.1    Ellenson, L.H.2    Nemes, A.3
  • 17
    • 0034995242 scopus 로고    scopus 로고
    • T cell-specific loss of Pten leads to defects in central and peripheral tolerance
    • Suzuki A, Yamaguchi MT, Ohteki T et al. T cell-specific loss of Pten leads to defects in central and peripheral tolerance. Immunity 2001; 14: 523-34.
    • (2001) Immunity , vol.14 , pp. 523-534
    • Suzuki, A.1    Yamaguchi, M.T.2    Ohteki, T.3
  • 18
    • 0034635264 scopus 로고    scopus 로고
    • Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration
    • Sasaki T, Irie-Sasaki J, Jones RG et al. Function of PI3Kgamma in thymocyte development, T cell activation, and neutrophil migration. Science 2000; 287: 1040-6.
    • (2000) Science , vol.287 , pp. 1040-1046
    • Sasaki, T.1    Irie-Sasaki, J.2    Jones, R.G.3
  • 19
    • 0034107671 scopus 로고    scopus 로고
    • Increased phosphoinositide 3-kinase activity induces a lymphoproliferative disorder and contributes to tumor generation in vivo
    • Borlado LR, Redondo C, Alvarez B et al. Increased phosphoinositide 3-kinase activity induces a lymphoproliferative disorder and contributes to tumor generation in vivo. FASEB J 2000; 14: 895-903.
    • (2000) FASEB J , vol.14 , pp. 895-903
    • Borlado, L.R.1    Redondo, C.2    Alvarez, B.3
  • 20
    • 0037309972 scopus 로고    scopus 로고
    • Keratinocyte-specific Pten deficiency results in epidermal hyperplasia, accelerated hair follicle morphogenesis and tumor formation
    • Suzuki A, Itami S, Ohishi M et al. Keratinocyte-specific Pten deficiency results in epidermal hyperplasia, accelerated hair follicle morphogenesis and tumor formation. Cancer Res 2003; 63: 674-81.
    • (2003) Cancer Res , vol.63 , pp. 674-681
    • Suzuki, A.1    Itami, S.2    Ohishi, M.3
  • 21
    • 33747134769 scopus 로고    scopus 로고
    • Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN
    • Zhao M, Song B, Pu J et al. Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN. Nature 2006; 442: 457-60.
    • (2006) Nature , vol.442 , pp. 457-460
    • Zhao, M.1    Song, B.2    Pu, J.3
  • 22
    • 85047694402 scopus 로고    scopus 로고
    • Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas
    • Horie Y, Suzuki A, Kataoka E et al. Hepatocyte-specific Pten deficiency results in steatohepatitis and hepatocellular carcinomas. J Clin Invest 2004; 113: 1774-83.
    • (2004) J Clin Invest , vol.113 , pp. 1774-1783
    • Horie, Y.1    Suzuki, A.2    Kataoka, E.3
  • 23
    • 33748999833 scopus 로고    scopus 로고
    • Hyperplasia and carcinomas in Pten-deficient mice and reduced PTEN protein in human bladder cancer patients
    • Tsuruta H, Kishimoto H, Sasaki T et al. Hyperplasia and carcinomas in Pten-deficient mice and reduced PTEN protein in human bladder cancer patients. Cancer Res 2006; 66: 8389-96.
    • (2006) Cancer Res , vol.66 , pp. 8389-8396
    • Tsuruta, H.1    Kishimoto, H.2    Sasaki, T.3
  • 24
    • 20944433657 scopus 로고    scopus 로고
    • Activating mutations of the tyrosine kinase receptor FGFR3 are associated with benign skin tumors in mice and humans
    • Logie A, Dunois-Larde C, Rosty C et al. Activating mutations of the tyrosine kinase receptor FGFR3 are associated with benign skin tumors in mice and humans. Hum Mol Genet 2005; 14: 1153-60.
    • (2005) Hum Mol Genet , vol.14 , pp. 1153-1160
    • Logie, A.1    Dunois-Larde, C.2    Rosty, C.3
  • 25
    • 0037099540 scopus 로고    scopus 로고
    • Overexpression of epidermal growth factor receptor in urothelium elicits urothelial hyperplasia and promotes bladder tumor growth
    • Cheng J, Huang H, Zhang ZT et al. Overexpression of epidermal growth factor receptor in urothelium elicits urothelial hyperplasia and promotes bladder tumor growth. Cancer Res 2002; 62: 4157-63.
    • (2002) Cancer Res , vol.62 , pp. 4157-4163
    • Cheng, J.1    Huang, H.2    Zhang, Z.T.3
  • 26
    • 0035848685 scopus 로고    scopus 로고
    • Role of Ha-ras activation in superficial papillary pathway of urothelial tumor formation
    • Zhang ZT, Pak J, Huang HY et al. Role of Ha-ras activation in superficial papillary pathway of urothelial tumor formation. Oncogene 2001; 20: 1973-80.
    • (2001) Oncogene , vol.20 , pp. 1973-1980
    • Zhang, Z.T.1    Pak, J.2    Huang, H.Y.3
  • 27
    • 34948850396 scopus 로고    scopus 로고
    • Pten controls lung morphogenesis, bronchoalveolar stem cells, and onset of lung adenocarcinomas in mice
    • Yanagi S, Kishimoto H, Kawahara K et al. Pten controls lung morphogenesis, bronchoalveolar stem cells, and onset of lung adenocarcinomas in mice. J Clin Invest 2007; 117: 2929-40.
    • (2007) J Clin Invest , vol.117 , pp. 2929-2940
    • Yanagi, S.1    Kishimoto, H.2    Kawahara, K.3
  • 29
    • 0030613856 scopus 로고    scopus 로고
    • Requirement for Valpha14 NKT cells in IL-12-mediated rejection of tumors
    • Cui J, Shin T, Kawano T et al. Requirement for Valpha14 NKT cells in IL-12-mediated rejection of tumors. Science 1997; 278: 1623-6.
    • (1997) Science , vol.278 , pp. 1623-1626
    • Cui, J.1    Shin, T.2    Kawano, T.3
  • 30
    • 24344446438 scopus 로고    scopus 로고
    • The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis
    • Hamada K, Sasaki T, Koni PA et al. The PTEN/PI3K pathway governs normal vascular development and tumor angiogenesis. Genes Dev 2005; 19: 2054-65.
    • (2005) Genes Dev , vol.19 , pp. 2054-2065
    • Hamada, K.1    Sasaki, T.2    Koni, P.A.3
  • 31
    • 34147139532 scopus 로고    scopus 로고
    • The Pten/PI3K pathway governs the homeostasis of Valpha14iNKT cells
    • Kishimoto H, Ohteki T, Yajima N et al. The Pten/PI3K pathway governs the homeostasis of Valpha14iNKT cells. Blood 2007; 109: 3316-24.
    • (2007) Blood , vol.109 , pp. 3316-3324
    • Kishimoto, H.1    Ohteki, T.2    Yajima, N.3
  • 32
    • 0038067837 scopus 로고    scopus 로고
    • Conditional loss of PTEN leads to testicular teratoma and enhances embryonic germ cell production
    • Kimura T, Suzuki A, Fujita Y et al. Conditional loss of PTEN leads to testicular teratoma and enhances embryonic germ cell production. Development 2003; 130: 1691-700.
    • (2003) Development , vol.130 , pp. 1691-1700
    • Kimura, T.1    Suzuki, A.2    Fujita, Y.3
  • 33
    • 10744233783 scopus 로고    scopus 로고
    • Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten
    • Backman SA, Ghazarian D, So K et al. Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten. Proc Natl Acad Sci USA 2004; 101: 1725-30.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 1725-1730
    • Backman, S.A.1    Ghazarian, D.2    So, K.3
  • 34
    • 10744222860 scopus 로고    scopus 로고
    • Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer
    • Wang S, Gao J, Lei Q et al. Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer. Cancer Cell 2003; 4: 209-21.
    • (2003) Cancer Cell , vol.4 , pp. 209-221
    • Wang, S.1    Gao, J.2    Lei, Q.3
  • 35
    • 24944572259 scopus 로고    scopus 로고
    • Pten constrains centroacinar cell expansion and malignant transformation in the pancreas
    • Stanger BZ, Stiles B, Lauwers GY et al. Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer Cell 2005; 8: 185-95.
    • (2005) Cancer Cell , vol.8 , pp. 185-195
    • Stanger, B.Z.1    Stiles, B.2    Lauwers, G.Y.3
  • 36
    • 0036714806 scopus 로고    scopus 로고
    • Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland
    • Li G, Robinson GW, Lesche R et al. Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland. Development 2002; 129: 4159-70.
    • (2002) Development , vol.129 , pp. 4159-4170
    • Li, G.1    Robinson, G.W.2    Lesche, R.3
  • 37
    • 33847011426 scopus 로고    scopus 로고
    • Pten loss in the mouse thyroid causes goiter and follicular adenomas: Insights into thyroid function and Cowden disease pathogenesis
    • Yeager N, Klein-Szanto A, Kimura S, Di Cristofano A. Pten loss in the mouse thyroid causes goiter and follicular adenomas: Insights into thyroid function and Cowden disease pathogenesis. Cancer Res 2007; 67: 959-66.
    • (2007) Cancer Res , vol.67 , pp. 959-966
    • Yeager, N.1    Klein-Szanto, A.2    Kimura, S.3    Di Cristofano, A.4
  • 38
    • 33745856213 scopus 로고    scopus 로고
    • Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice
    • Xu X, Kobayashi S, Qiao W et al. Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice. J Clin Invest 2006; 116: 1843-52.
    • (2006) J Clin Invest , vol.116 , pp. 1843-1852
    • Xu, X.1    Kobayashi, S.2    Qiao, W.3
  • 39
    • 34250013899 scopus 로고    scopus 로고
    • The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomas
    • Hernando E, Charytonowicz E, Dudas ME et al. The AKT-mTOR pathway plays a critical role in the development of leiomyosarcomas. Nat Med 2007; 13: 748-53.
    • (2007) Nat Med , vol.13 , pp. 748-753
    • Hernando, E.1    Charytonowicz, E.2    Dudas, M.E.3
  • 40
    • 0035949707 scopus 로고    scopus 로고
    • Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression
    • Kwabi-Addo B, Giri D, Schmidt K et al. Haploinsufficiency of the Pten tumor suppressor gene promotes prostate cancer progression. Proc Natl Acad Sci USA 2001; 98: 11.563-8.
    • (2001) Proc Natl Acad Sci USA , vol.98
    • Kwabi-Addo, B.1    Giri, D.2    Schmidt, K.3
  • 41
    • 31944448885 scopus 로고    scopus 로고
    • Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation
    • Wang S, Garcia AJ, Wu M, Lawson DA, Witte ON, Wu H. Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation. Proc Natl Acad Sci USA 2006; 103: 1480-5.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 1480-1485
    • Wang, S.1    Garcia, A.J.2    Wu, M.3    Lawson, D.A.4    Witte, O.N.5    Wu, H.6
  • 42
    • 33846600427 scopus 로고    scopus 로고
    • PTEN-deficient intestinal stem cells initiate intestinal polyposis
    • He XC, Yin T, Grindley JC et al. PTEN-deficient intestinal stem cells initiate intestinal polyposis. Nat Genet 2007; 39: 189-98.
    • (2007) Nat Genet , vol.39 , pp. 189-198
    • He, X.C.1    Yin, T.2    Grindley, J.C.3
  • 43
    • 0035824396 scopus 로고    scopus 로고
    • Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo
    • Groszer M, Erickson R, Scripture-Adams DD et al. Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo. Science 2001; 294: 2186-9.
    • (2001) Science , vol.294 , pp. 2186-2189
    • Groszer, M.1    Erickson, R.2    Scripture-Adams, D.D.3
  • 44
    • 33845999615 scopus 로고    scopus 로고
    • Essential role for nuclear PTEN in maintaining chromosomal integrity
    • Shen WH, Balajee AS, Wang J et al. Essential role for nuclear PTEN in maintaining chromosomal integrity. Cell 2007; 128: 157-70.
    • (2007) Cell , vol.128 , pp. 157-170
    • Shen, W.H.1    Balajee, A.S.2    Wang, J.3
  • 45
    • 18644372367 scopus 로고    scopus 로고
    • Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways
    • Crackower MA, Oudit GY, Kozieradzki I et al. Regulation of myocardial contractility and cell size by distinct PI3K-PTEN signaling pathways. Cell 2002; 110: 737-49.
    • (2002) Cell , vol.110 , pp. 737-749
    • Crackower, M.A.1    Oudit, G.Y.2    Kozieradzki, I.3
  • 46
    • 19944430614 scopus 로고    scopus 로고
    • Muscle-specific Pten deletion protects against insulin resistance and diabetes
    • Wijesekara N, Konrad D, Eweida M et al. Muscle-specific Pten deletion protects against insulin resistance and diabetes. Mol Cell Biol 2005; 25: 1135-45.
    • (2005) Mol Cell Biol , vol.25 , pp. 1135-1145
    • Wijesekara, N.1    Konrad, D.2    Eweida, M.3
  • 47
    • 0035733762 scopus 로고    scopus 로고
    • Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease
    • Backman SA, Stambolic V, Suzuki A et al. Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease. Nat Genet 2001; 29: 396-403.
    • (2001) Nat Genet , vol.29 , pp. 396-403
    • Backman, S.A.1    Stambolic, V.2    Suzuki, A.3
  • 48
    • 0037416216 scopus 로고    scopus 로고
    • Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination
    • Suzuki A, Kaisho T, Ohishi M et al. Critical roles of Pten in B cell homeostasis and immunoglobulin class switch recombination. J Exp Med 2003; 197: 657-67.
    • (2003) J Exp Med , vol.197 , pp. 657-667
    • Suzuki, A.1    Kaisho, T.2    Ohishi, M.3
  • 49
    • 33847791590 scopus 로고    scopus 로고
    • Lifelong accumulation of bone in mice lacking Pten in osteoblasts
    • Liu X, Bruxvoort KJ, Zylstra CR et al. Lifelong accumulation of bone in mice lacking Pten in osteoblasts. Proc Natl Acad Sci USA 2007; 104: 2259-64.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 2259-2264
    • Liu, X.1    Bruxvoort, K.J.2    Zylstra, C.R.3
  • 50
    • 0035909946 scopus 로고    scopus 로고
    • Tumor induction by an Lck-MyrAkt transgene is delayed by mechanisms controlling the size of the thymus
    • Malstrom S, Tili E, Kappes D, Ceci JD, Tsichlis PN. Tumor induction by an Lck-MyrAkt transgene is delayed by mechanisms controlling the size of the thymus. Proc Natl Acad Sci USA 2001; 98: 14.967-72.
    • (2001) Proc Natl Acad Sci USA , vol.98
    • Malstrom, S.1    Tili, E.2    Kappes, D.3    Ceci, J.D.4    Tsichlis, P.N.5
  • 53
    • 0034697962 scopus 로고    scopus 로고
    • The EGF receptor provides an essential survival signal for SOS-dependent skin tumor development
    • Sibilia M, Fleischmann A, Behrens A et al. The EGF receptor provides an essential survival signal for SOS-dependent skin tumor development. Cell 2000; 102: 211-20.
    • (2000) Cell , vol.102 , pp. 211-220
    • Sibilia, M.1    Fleischmann, A.2    Behrens, A.3
  • 54
    • 0033618410 scopus 로고    scopus 로고
    • Multiple ras effector pathways contribute to G(1) cell cycle progression
    • Gille H, Downward J. Multiple ras effector pathways contribute to G(1) cell cycle progression. J Biol Chem 1999; 274: 22033-40.
    • (1999) J Biol Chem , vol.274 , pp. 22033-22040
    • Gille, H.1    Downward, J.2
  • 56
    • 33846004477 scopus 로고    scopus 로고
    • PTEN enters the nuclear age
    • Baker SJ. PTEN enters the nuclear age. Cell 2007; 128: 25-8.
    • (2007) Cell , vol.128 , pp. 25-28
    • Baker, S.J.1
  • 57
    • 24944568790 scopus 로고    scopus 로고
    • Nuclear-cytoplasmic partitioning of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) differentially regulates the cell cycle and apoptosis
    • Chung JH, Eng C. Nuclear-cytoplasmic partitioning of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) differentially regulates the cell cycle and apoptosis. Cancer Res 2005; 65: 8096-100.
    • (2005) Cancer Res , vol.65 , pp. 8096-8100
    • Chung, J.H.1    Eng, C.2
  • 58
    • 20144384760 scopus 로고    scopus 로고
    • Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) has nuclear localization signal-like sequences for nuclear import mediated by major vault protein
    • Chung JH, Ginn-Pease ME, Eng C. Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) has nuclear localization signal-like sequences for nuclear import mediated by major vault protein. Cancer Res 2005; 65: 4108-16.
    • (2005) Cancer Res , vol.65 , pp. 4108-4116
    • Chung, J.H.1    Ginn-Pease, M.E.2    Eng, C.3
  • 60
    • 0036568378 scopus 로고    scopus 로고
    • Nuclear PTEN expression and clinicopathologic features in a population-based series of primary cutaneous melanoma
    • Whiteman DC, Zhou XP, Cummings MC, Pavey S, Hayward NK, Eng C. Nuclear PTEN expression and clinicopathologic features in a population-based series of primary cutaneous melanoma. Int J Cancer 2002; 99: 63-7.
    • (2002) Int J Cancer , vol.99 , pp. 63-67
    • Whiteman, D.C.1    Zhou, X.P.2    Cummings, M.C.3    Pavey, S.4    Hayward, N.K.5    Eng, C.6
  • 61
    • 0041450058 scopus 로고    scopus 로고
    • PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms
    • Freeman DJ, Li AG, Wei G et al. PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms. Cancer Cell 2003; 3: 117-30.
    • (2003) Cancer Cell , vol.3 , pp. 117-130
    • Freeman, D.J.1    Li, A.G.2    Wei, G.3
  • 62
    • 23244460597 scopus 로고    scopus 로고
    • Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis
    • Chen Z, Trotman LC, Shaffer D et al. Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature 2005; 436: 725-30.
    • (2005) Nature , vol.436 , pp. 725-730
    • Chen, Z.1    Trotman, L.C.2    Shaffer, D.3
  • 63
    • 0842263745 scopus 로고    scopus 로고
    • Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway
    • Miyauchi H, Minamino T, Tateno K, Kunieda T, Toko H, Komuro I. Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21-dependent pathway. Embo J 2004; 23: 212-20.
    • (2004) Embo J , vol.23 , pp. 212-220
    • Miyauchi, H.1    Minamino, T.2    Tateno, K.3    Kunieda, T.4    Toko, H.5    Komuro, I.6
  • 64
    • 14544282456 scopus 로고    scopus 로고
    • Cellular transformation by the MSP58 oncogene is inhibited by its physical interaction with the PTEN tumor suppressor
    • Okumura K, Zhao M, Depinho RA, Furnari FB, Cavenee WK. Cellular transformation by the MSP58 oncogene is inhibited by its physical interaction with the PTEN tumor suppressor. Proc Natl Acad Sci USA 2005; 102: 2703-6.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 2703-2706
    • Okumura, K.1    Zhao, M.2    Depinho, R.A.3    Furnari, F.B.4    Cavenee, W.K.5
  • 66
    • 30944461586 scopus 로고    scopus 로고
    • PTEN and GSK3beta: Key regulators of progression to androgen-independent prostate cancer
    • Mulholland DJ, Dedhar S, Wu H, Nelson CC. PTEN and GSK3beta: Key regulators of progression to androgen-independent prostate cancer. Oncogene 2006; 25: 329-37.
    • (2006) Oncogene , vol.25 , pp. 329-337
    • Mulholland, D.J.1    Dedhar, S.2    Wu, H.3    Nelson, C.C.4
  • 67
    • 34147101043 scopus 로고    scopus 로고
    • Insulin-like growth factor 1/insulin signaling activates androgen signaling through direct interactions of Foxo1 with androgen receptor
    • Fan W, Yanase T, Morinaga H et al. Insulin-like growth factor 1/insulin signaling activates androgen signaling through direct interactions of Foxo1 with androgen receptor. J Biol Chem 2007; 282: 7329-38.
    • (2007) J Biol Chem , vol.282 , pp. 7329-7338
    • Fan, W.1    Yanase, T.2    Morinaga, H.3
  • 68
    • 5044229903 scopus 로고    scopus 로고
    • Regulation of androgen receptor signaling by PTEN (phosphatase and tensin homolog deleted on chromosome 10) tumor suppressor through distinct mechanisms in prostate cancer cells
    • Lin HK, Hu YC, Lee DK, Chang C. Regulation of androgen receptor signaling by PTEN (phosphatase and tensin homolog deleted on chromosome 10) tumor suppressor through distinct mechanisms in prostate cancer cells. Mol Endocrinol 2004; 18: 2409-23.
    • (2004) Mol Endocrinol , vol.18 , pp. 2409-2423
    • Lin, H.K.1    Hu, Y.C.2    Lee, D.K.3    Chang, C.4
  • 69
    • 33748038440 scopus 로고    scopus 로고
    • Emergence of androgen independence at early stages of prostate cancer progression in nkx3.1; pten mice
    • Gao H, Ouyang X, Banach-Petrosky WA, Shen MM, Abate-Shen C. Emergence of androgen independence at early stages of prostate cancer progression in nkx3.1; pten mice. Cancer Res 2006; 66: 7929-33.
    • (2006) Cancer Res , vol.66 , pp. 7929-7933
    • Gao, H.1    Ouyang, X.2    Banach-Petrosky, W.A.3    Shen, M.M.4    Abate-Shen, C.5
  • 70
    • 0035971181 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: A new model for anti-estrogen resistance
    • Campbell RA, Bhat-Nakshatri P, Patel NM, Constantinidou D, Ali S, Nakshatri H. Phosphatidylinositol 3-kinase/AKT-mediated activation of estrogen receptor alpha: A new model for anti-estrogen resistance. J Biol Chem 2001; 276: 9817-24.
    • (2001) J Biol Chem , vol.276 , pp. 9817-9924
    • Campbell, R.A.1    Bhat-Nakshatri, P.2    Patel, N.M.3    Constantinidou, D.4    Ali, S.5    Nakshatri, H.6
  • 72
    • 0033615538 scopus 로고    scopus 로고
    • Crystal structure of the PTEN tumor suppressor: Implications for its phosphoinositide phosphatase activity and membrane association
    • Lee JO, Yang H, Georgescu MM et al. Crystal structure of the PTEN tumor suppressor: Implications for its phosphoinositide phosphatase activity and membrane association. Cell 1999; 99: 323-34.
    • (1999) Cell , vol.99 , pp. 323-334
    • Lee, J.O.1    Yang, H.2    Georgescu, M.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.