Involvement of Akt-1 and mTOR in sensitivity of breast cancer to targeted therapy

Oncotarget

Volumn 2, Issue 7, 2011, Pages 538-550

  Sokolosky, Melissa L ^a   Stadelman, Kristin M ^a   Chappell, William H ^a   Abrams, Stephen L ^a   Martelli, Alberto M ^b,c   Stivala, Franca ^d   Libra, Massimo ^d   Nicoletti, Ferdinando ^d   Drobot, Lyudmyla B ^e   Franklin, Richard A ^a   Steelman, Linda S ^a   McCubrey, James A ^a  

^a EAST CAROLINA UNIVERSITY   (United States)

^b UNIVERSITY OF BOLOGNA   (Italy)

^c CNR   (Italy)

^d UNIVERSITY OF CATANIA   (Italy)

^e PALLADIN INSTITUTE OF BIOCHEMISTRY   (Ukraine)

Author keywords

Akt; Drug resistance; mTOR; Targeted therapy

Indexed keywords

AFIMOXIFENE; DOXORUBICIN; ETOPOSIDE; MAMMALIAN TARGET OF RAPAMYCIN; PACLITAXEL; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; RAPAMYCIN; AKT1 PROTEIN, HUMAN; ANTINEOPLASTIC AGENT; MTOR PROTEIN, HUMAN; TAMOXIFEN; TARGET OF RAPAMYCIN KINASE;

AKT1 GENE; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL PROLIFERATION; CHEMOSENSITIVITY; DRUG POTENTIATION; ENZYME ACTIVATION; GENE; GENE EXPRESSION; HUMAN; HUMAN CELL; IC 50; INHIBITION KINETICS; SIGNAL TRANSDUCTION; TREATMENT RESPONSE; BREAST TUMOR; DRUG ANTAGONISM; DRUG EFFECT; DRUG RESISTANCE; FEMALE; GENETICS; METABOLISM; MOLECULARLY TARGETED THERAPY; PATHOLOGY; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; ETOPOSIDE; FEMALE; HUMANS; MOLECULAR TARGETED THERAPY; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; SIROLIMUS; TAMOXIFEN; TOR SERINE-THREONINE KINASES;

EID: 84856670292     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.302     Document Type: Article

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