메뉴 건너뛰기




Volumn 8, Issue 7, 2009, Pages 1003-1006

mTORC1 signaling governs hematopoietic stem cell quiescence

Author keywords

Cell growth; Hematopoietic stem cell; mTORC1; Quiescence; TSC

Indexed keywords

ADENYLATE KINASE; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROMYELOCYTIC LEUKEMIA PROTEIN; UNCLASSIFIED DRUG;

EID: 65949104286     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.8.7.8045     Document Type: Review
Times cited : (93)

References (28)
  • 1
    • 33645469482 scopus 로고    scopus 로고
    • Stem cells and their niches
    • Moore KA, Lemischka IR. Stem cells and their niches. Science 2006; 311:1880-1885.
    • (2006) Science , vol.311 , pp. 1880-1885
    • Moore, K.A.1    Lemischka, I.R.2
  • 2
    • 39349096526 scopus 로고    scopus 로고
    • Hematopoiesis: An evolving paradigm for stem cell biology
    • Orkin SH, Zon LI. Hematopoiesis: an evolving paradigm for stem cell biology. Cell 2008; 132:631-644
    • (2008) Cell , vol.132 , pp. 631-644
    • Orkin, S.H.1    Zon, L.I.2
  • 3
    • 39149144034 scopus 로고    scopus 로고
    • Stem cells and niches: Mechanisms that promote stem cell maintenance throughout life
    • Morrison SJ, Spradling AC. Stem cells and niches: mechanisms that promote stem cell maintenance throughout life. Cell 2008; 132:598-611.
    • (2008) Cell , vol.132 , pp. 598-611
    • Morrison, S.J.1    Spradling, A.C.2
  • 4
    • 38349132624 scopus 로고    scopus 로고
    • Deconstructing stem cell self-renewal: Genetic insights into cell cycle regulation
    • Orford KW, Scadden DT. Deconstructing stem cell self-renewal: genetic insights into cell cycle regulation. Nat Rev Genet 2008; 9:115-128
    • (2008) Nat Rev Genet , vol.9 , pp. 115-128
    • Orford, K.W.1    Scadden, D.T.2
  • 5
    • 33748437829 scopus 로고    scopus 로고
    • Hematopoietic stem cell self-renewal
    • DOI 10.1016/j.gde.2006.08.011, PII S0959437X06001626, Differentation and Gene Regulation
    • Akala OO, Clarke MF. Hematopoietic stem cell self-renewal. Curr Opin Genet Dev 2006; 16:496-501. (Pubitemid 44345208)
    • (2006) Current Opinion in Genetics and Development , vol.16 , Issue.5 , pp. 496-501
    • Akala, O.O.1    Clarke, M.F.2
  • 6
    • 0033593316 scopus 로고    scopus 로고
    • Size control in animal development
    • DOI 10.1016/S0092-8674(00)80563-2
    • Conlon I, Raff M. Size control in animal development. Cell 1999; 96:235-244 (Pubitemid 29059353)
    • (1999) Cell , vol.96 , Issue.2 , pp. 235-244
    • Conlon, I.1    Raff, M.2
  • 7
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • DOI 10.1016/j.cell.2006.01.016, PII S0092867406001085
    • Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell 2006; 124:471-484 (Pubitemid 43199434)
    • (2006) Cell , vol.124 , Issue.3 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 8
    • 27744588780 scopus 로고    scopus 로고
    • Tuberous sclerosis: A GAP at the crossroads of multiple signaling pathways
    • Kwiatkowski DJ, Manning BD. Tuberous sclerosis: a GAP at the crossroads of multiple signaling pathways. Hum Mol Genet 2005; 14:251-258
    • (2005) Hum Mol Genet , vol.14 , pp. 251-258
    • Kwiatkowski, D.J.1    Manning, B.D.2
  • 9
    • 33750044112 scopus 로고    scopus 로고
    • Stress and mTORture signaling
    • DOI 10.1038/sj.onc.1209889, PII 1209889
    • Reiling JH, Sabatini DM. Stress and mTORture signaling. Oncogene 2006; 25:6373-6383 (Pubitemid 44582282)
    • (2006) Oncogene , vol.25 , Issue.48 , pp. 6373-6383
    • Reiling, J.H.1    Sabatini, D.M.2
  • 10
    • 33750058023 scopus 로고    scopus 로고
    • Upstream of the mammalian target of rapamycin: Do all roads pass through mTOR?
    • Corradetti MN, Guan KL. Upstream of the mammalian target of rapamycin: do all roads pass through mTOR? Oncogene 2006; 25:6347-6360
    • (2006) Oncogene , vol.25 , pp. 6347-6360
    • Corradetti, M.N.1    Guan, K.L.2
  • 11
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB Signaling: Navigating Downstream
    • DOI 10.1016/j.cell.2007.06.009, PII S0092867407007751
    • Manning BD, Cantley LC. AKT/PKB signaling: navigating downstream. Cell 2007; 129:1261-1274 (Pubitemid 46962095)
    • (2007) Cell , vol.129 , Issue.7 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 12
    • 0345167800 scopus 로고    scopus 로고
    • TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival
    • DOI 10.1016/S0092-8674(03)00929-2
    • Inoki K, Zhu T, Guan KL. TSC2 mediates cellular energy response to control cell growth and survival. Cell 2003; 115:577-590 (Pubitemid 37506046)
    • (2003) Cell , vol.115 , Issue.5 , pp. 577-590
    • Inoki, K.1    Zhu, T.2    Guan, K.-L.3
  • 15
    • 38349056675 scopus 로고    scopus 로고
    • Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling
    • DeYoung MP, Horak P, Sofer A, Sgroi D, Ellisen LW. Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling. Genes Dev 2008; 22:239-251
    • (2008) Genes Dev , vol.22 , pp. 239-251
    • DeYoung, M.P.1    Horak, P.2    Sofer, A.3    Sgroi, D.4    Ellisen, L.W.5
  • 16
    • 33747488399 scopus 로고    scopus 로고
    • PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR
    • Bernardi R, Guernah I, Jin D, Grisendi S, Alimonti A, Teruya-Feldstein J, et al. PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR. Nature 2006; 442:779-785
    • (2006) Nature , vol.442 , pp. 779-785
    • Bernardi, R.1    Guernah, I.2    Jin, D.3    Grisendi, S.4    Alimonti, A.5    Teruya-Feldstein, J.6
  • 19
    • 33646376411 scopus 로고    scopus 로고
    • Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
    • Yilmaz OH, Valdez R, Theisen BK, Guo W, Ferguson DO, Wu H, et al. Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature 2006; 441:475-482
    • (2006) Nature , vol.441 , pp. 475-482
    • Yilmaz, O.H.1    Valdez, R.2    Theisen, B.K.3    Guo, W.4    Ferguson, D.O.5    Wu, H.6
  • 20
    • 33646351002 scopus 로고    scopus 로고
    • PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention
    • Zhang J, Grindley JC, Yin T, Jayasinghe S, He XC, Ross JT, et al. PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention. Nature 2006; 441:518-522
    • (2006) Nature , vol.441 , pp. 518-522
    • Zhang, J.1    Grindley, J.C.2    Yin, T.3    Jayasinghe, S.4    He, X.C.5    Ross, J.T.6
  • 21
    • 58049196780 scopus 로고    scopus 로고
    • mTORC1-dependent and -independent regulation of stem cell renewal, differentiation and mobilization
    • Gan B, Sahin E, Jiang S, Sanchez-Aguilera A, Scott KL, Chin L, et al. mTORC1-dependent and -independent regulation of stem cell renewal, differentiation and mobilization. Proc Natl Acad Sci USA 2008; 105:19384-19389
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 19384-19389
    • Gan, B.1    Sahin, E.2    Jiang, S.3    Sanchez-Aguilera, A.4    Scott, K.L.5    Chin, L.6
  • 22
    • 53349091768 scopus 로고    scopus 로고
    • TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species
    • Chen C, Liu Y, Liu R, Ikenoue T, Guan KL, Zheng P. TSC-mTOR maintains quiescence and function of hematopoietic stem cells by repressing mitochondrial biogenesis and reactive oxygen species. J Exp Med 2008.
    • (2008) J Exp Med
    • Chen, C.1    Liu, Y.2    Liu, R.3    Ikenoue, T.4    Guan, K.L.5    Zheng, P.6
  • 23
    • 33846419112 scopus 로고    scopus 로고
    • FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress
    • Tothova Z, Kollipara R, Huntly BJ, Lee BH, Castrillon DH, Cullen DE, et al. FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress. Cell 2007; 128:325-339
    • (2007) Cell , vol.128 , pp. 325-339
    • Tothova, Z.1    Kollipara, R.2    Huntly, B.J.3    Lee, B.H.4    Castrillon, D.H.5    Cullen, D.E.6
  • 25
    • 44349166602 scopus 로고    scopus 로고
    • PML targeting eradicates quiescent leukaemia-initiating cells
    • Ito K, Bernardi R, Morotti A, Matsuoka S, Saglio G, Ikeda Y, et al. PML targeting eradicates quiescent leukaemia-initiating cells. Nature 2008; 453:1072-1078
    • (2008) Nature , vol.453 , pp. 1072-1078
    • Ito, K.1    Bernardi, R.2    Morotti, A.3    Matsuoka, S.4    Saglio, G.5    Ikeda, Y.6
  • 26
    • 42149132696 scopus 로고    scopus 로고
    • Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL
    • Matsuoka S, Oike Y, Onoyama I, Iwama A, Arai F, Takubo K, et al. Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL. Genes Dev 2008; 22:986-991
    • (2008) Genes Dev , vol.22 , pp. 986-991
    • Matsuoka, S.1    Oike, Y.2    Onoyama, I.3    Iwama, A.4    Arai, F.5    Takubo, K.6
  • 27
    • 38549086019 scopus 로고    scopus 로고
    • FBW7 ubiquitin ligase: A tumour suppressor at the crossroads of cell division, growth and differentiation
    • Welcker M, Clurman BE. FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation. Nat Rev Cancer 2008; 8:83-93.
    • (2008) Nat Rev Cancer , vol.8 , pp. 83-93
    • Welcker, M.1    Clurman, B.E.2
  • 28
    • 51749095471 scopus 로고    scopus 로고
    • FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression
    • Mao JH, Kim IJ, Wu D, Climent J, Kang HC, DelRosario R, et al. FBXW7 targets mTOR for degradation and cooperates with PTEN in tumor suppression. Science 2008; 321:1499-1502
    • (2008) Science , vol.321 , pp. 1499-1502
    • Mao, J.H.1    Kim, I.J.2    Wu, D.3    Climent, J.4    Kang, H.C.5    DelRosario, R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.