Inhibition of Aurora-A kinase induces cell cycle arrest in epithelial ovarian cancer stem cells by affecting NFκB pathway

Cell Cycle

Volumn 10, Issue 13, 2011, Pages 2206-2214

  Chefetz, Ilana ^a   Holmberg, Jennie C ^a   Alvero, Ayesha B ^a   Visintin, Irene ^a   Mor, Gil ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aurora A kinase; Cell cycle arrest; Nuclear factor kappaB; Ovarian cancer stem cells

Indexed keywords

AURORA A KINASE; AURORA KINASE INHIBITOR; CYTOKINE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MK 5108; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER STEM CELL; CELL ASSAY; CELL CYCLE ARREST; CELL GROWTH; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG INHIBITION; ENZYME ACTIVITY; ENZYME INHIBITION; EPITHELIAL OVARIAN CANCER STEM CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; POLYPLOIDY; REAL TIME ECHOGRAPHY; SIGNAL TRANSDUCTION;

EID: 79960012417     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.10.13.16348     Document Type: Article

References (29)

1. Lhomme C, Kerbrat P, Lejeune C, Guastalla JP, Fumoleau P, Goupil A, et al. Carboplatin plus paclitaxel in the first-line treatment of advanced ovarian cancer: preliminary results of a phase I study. Semin Oncol 1996; 23:48-54. (Pubitemid 26391380)
2. Colombo N, Van Gorp T, Parma G, Amant F, Gatta G, Sessa C, et al. Ovarian cancer. Crit Rev Oncol Hematol 2006; 60:159-79. (Pubitemid 44636248)
3. Dalerba P, Cho RW, Clarke MF. Cancer stem cells: models and concepts. Annu Rev Med 2007; 58:267-84. (Pubitemid 46706514)
4. Clarke MF, Dick JE, Dirks PB, Eaves CJ, Jamieson CH, Jones DL, et al. Cancer stem cells - perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res 2006; 66:9339-44. (Pubitemid 44623625)
5. Alvero AB, Chen R, Fu HH, Montagna M, Schwartz PE, Rutherford T, et al. Molecular phenotyping of human ovarian cancer stem cells unravels the mechanisms for repair and chemoresistance. Cell Cycle 2009; 8:158-66.
6. Alvero AB, Fu HH, Holmberg J, Visintin I, Mor L, Marquina CC, et al. Stem-like ovarian cancer cells can serve as tumor vascular progenitors. Stem Cells 2009; 27:2405-13.
7. Chen R, Alvero AB, Silasi DA, Kelly MG, Fest S, Visintin I, et al. Regulation of IKKbeta by miR-199a affects NFkappaB activity in ovarian cancer cells. Oncogene 2008; 27:4712-23.
8. Kelly MG, Alvero AB, Chen R, Silasi DA, Abrahams VM, Chan S, et al. TLR-4 signaling promotes tumor growth and paclitaxel chemoresistance in ovarian cancer. Cancer Res 2006; 66:3859-68.
9. Baud V, Karin M. Is NFkappaB a good target for cancer therapy? Hopes and pitfalls. Nat Rev Drug Discov 2009; 8:33-40.
10. Leizer AL, Alvero AB, Fu HH, Holmberg JC, Cheng YC, Silasi DA, et al. Regulation of inflammation by the NFkappaB pathway in ovarian cancer stem cells. Am J Reprod Immunol 65:438-47.
11. Dutertre S, Descamps S, Prigent C. On the role of aurora-A in centrosome function. Oncogene 2002; 21:6175-83.
12. Karthigeyan D, Prasad SB, Shandilya J, Agrawal S, Kundu TK. Biology of Aurora A kinase: Implications in cancer manifestation and therapy. Med Res Rev.
13. Yang SB, Zhou XB, Zhu HX, Quan LP, Bai JF, He J, et al. Amplification and overexpression of Aurora-A in esophageal squamous cell carcinoma. Oncol Rep 2007; 17:1083-8.
14. Samaras V, Stamatelli A, Samaras E, Arnaoutoglou C, Arnaoutoglou M, Stergiou I, et al. Comparative immunohistochemical analysis of aurora-A and aurora-B expression in human glioblastomas. Associations with proliferative activity and clinicopathological features. Pathol Res Pract 2009; 205:765-73.
15. Anand S, Penrhyn-Lowe S, Venkitaraman AR. AURORA-A amplification overrides the mitotic spindle assembly checkpoint, inducing resistance to Taxol. Cancer Cell 2003; 3:51-62. (Pubitemid 37443890)
16. Shimomura T, Hasako S, Nakatsuru Y, Mita T, Ichikawa K, Kodera T, et al. MK-5108, a highly selective Aurora-A kinase inhibitor, shows antitumor activity alone and in combination with docetaxel. Mol Cancer Ther 9:157-66.
17. Briassouli P, Chan F, Savage K, Reis-Filho JS, Linardopoulos S. Aurora-A regulation of nuclear factor-kappaB signaling by phosphorylation of IkappaBalpha. Cancer Res 2007; 67:1689-95. (Pubitemid 46383395)
18. Kamada K, Yamada Y, Hirao T, Fujimoto H, Takahama Y, Ueno M, et al. Amplification/overexpression of Aurora-A in human gastric carcinoma: potential role in differentiated type gastric carcinogenesis. Oncol Rep 2004; 12:593-9.
19. Nishida N, Nagasaka T, Kashiwagi K, Boland CR, Goel A. High copy amplification of the Aurora-A gene is associated with chromosomal instability phenotype in human colorectal cancers. Cancer Biol Ther 2007; 6:525-33. (Pubitemid 47328326)
20. Xia LP, Zhou FF, Yang MT, Liu Q. [Roles of Aurora-A in tumorigenesis and prognosis of breast cancer]. Ai Zheng 2009; 28:668-72.
21. Lundell K, Thulin P, Hamsten A, Ehrenborg E. Alternative splicing of human peroxisome proliferator-activated receptor delta (PPAR delta): effects on translation efficiency and trans-activation ability. BMC Mol Biol 2007; 8:70.
22. El-Sheikh A, Fan R, Birks D, Donson A, Foreman NK, Vibhakar R. Inhibition of Aurora Kinase A enhances chemosensitivity of medulloblastoma cell lines. Pediatr Blood Cancer 55:35-41.
23. Georgieva I, Koychev D, Wang Y, Holstein J, Hopfenmuller W, Zeitz M, et al. ZM447439, a novel promising aurora kinase inhibitor, provokes antiproliferative and proapoptotic effects alone and in combination with bio- and chemotherapeutic agents in gastroenteropancreatic neuroendocrine tumor cell lines. Neuroendocrinology 91:121-30.
24. Gorgun G, Calabrese E, Hideshima T, Ecsedy J, Perrone G, Mani M, et al. A novel Aurora-A kinase inhibitor MLN8237 induces cytotoxicity and cell cycle arrest in multiple myeloma. Blood 115:5202-13.
25. Kung AL, Sherwood SW, Schimke RT. Cell line-specific differences in the control of cell cycle progression in the absence of mitosis. Proc Natl Acad Sci USA 1990; 87:9553-7. (Pubitemid 120016481)
26. Tovar C, Higgins B, Deo D, Kolinsky K, Liu JJ, Heimbrook DC, et al. Small-molecule inducer of cancer cell polyploidy promotes apoptosis or senescence: Implications for therapy. Cell Cycle 9:3364-75.
27. Harrington EA, Bebbington D, Moore J, Rasmussen RK, Ajose-Adeogun AO, Nakayama T, et al. VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo. Nat Med 2004; 10:262-7. (Pubitemid 38667616)
28. Li CC, Dai RM, Longo DL. Inactivation of NFkappaB inhibitor IkappaB alpha: ubiquitin-dependent proteolysis and its degradation product. Biochem Biophys Res Commun 1995; 215:292-301.
29. Kamsteeg M, Rutherford T, Sapi E, Hanczaruk B, Shahabi S, Flick M, et al. Phenoxodiol - an isoflavone analog - induces apoptosis in chemoresistant ovarian cancer cells. Oncogene 2003; 22:2611-20. (Pubitemid 36605609)