Negative-feedback regulation of FGF signalling by DUSP6/MKP-3 is driven by ERK1/2 and mediated by Ets factor binding to a conserved site within the DUSP6/MKP-3 gene promoter

Biochemical Journal

Volumn 412, Issue 2, 2008, Pages 287-298

  Ekerot, Maria ^a   Stavridis, Marios P ^b   Delavaine, Laurent ^a   Mitchell, Michael P ^c   Staples, Christopher ^a   Owens, David M ^a   Keenan, Iain D ^a   Dickinson, Robin J ^a   Storey, Kate G ^b   Keyse, Stephen M ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

^c IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

Dual specificity phosphatase 6 (DUSP6); Fibroblast growth factor (FGF); Mitogen activated protein kinase (MAPK); Mitogen activated protein kinase phosphatase 3 (MKP 3); Phosphatase; Transcription

Indexed keywords

BINDING SITES; CELL GROWTH; ENZYME INHIBITION; SIGNAL TRANSDUCTION; TRANSCRIPTION;

DUAL SPECIFICITY PHOSPHATASE 6 (DUSP6); FIBROBLAST GROWTH FACTOR (FGF); MITOGEN ACTIVATED PROTEIN KINASE (MAPK); MITOGEN-ACTIVATED PROTEIN KINASE PHOSPHATASE-3 (MKP-3); PHOSPHATASE;

ENZYME ACTIVITY;

FIBROBLAST GROWTH FACTOR; GREEN FLUORESCENT PROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL CULTURE; GENE EXPRESSION; MOUSE; NEGATIVE FEEDBACK; NEUROECTODERM; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BASE SEQUENCE; BINDING SITES; CELL LINE; DUAL SPECIFICITY PHOSPHATASE 6; ENZYME ACTIVATION; FEEDBACK, BIOCHEMICAL; FIBROBLAST GROWTH FACTORS; GENE EXPRESSION REGULATION; HUMANS; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS C-ETS; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; TRANSGENES;

MURINAE; VERTEBRATA;

EID: 44449113769     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20071512     Document Type: Article

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