-
1
-
-
0033622470
-
Essential role of p38 MAP kinase in placental but not embryonic cardiovascular development
-
Adams RH, Porras A, Alonso G, Jones M, Vintersten K, Panelli S, Valladares A, Perez L, Klein R, Nebreda AR. Essential role of p38 MAP kinase in placental but not embryonic cardiovascular development. Mol Cell 6: 109-116, 2000.
-
(2000)
Mol Cell
, vol.6
, pp. 109-116
-
-
Adams, R.H.1
Porras, A.2
Alonso, G.3
Jones, M.4
Vintersten, K.5
Panelli, S.6
Valladares, A.7
Perez, L.8
Klein, R.9
Nebreda, A.R.10
-
2
-
-
0034708832
-
2-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)
-
2-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307). J Biol Chem 275: 9047-9054, 2000.
-
(2000)
J Biol Chem
, vol.275
, pp. 9047-9054
-
-
Aguirre, V.1
Uchida, T.2
Yenush, L.3
Davis, R.4
White, M.F.5
-
3
-
-
0037059330
-
Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action
-
Aguirre V, Werner ED, Giraud J, Lee YG, Shoelson SE, White MF. Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action. J Biol Chem 277: 1531-1537, 2002.
-
(2002)
J Biol Chem
, vol.277
, pp. 1531-1537
-
-
Aguirre, V.1
Werner, E.D.2
Giraud, J.3
Lee, Y.G.4
Shoelson, S.E.5
White, M.F.6
-
4
-
-
70149122305
-
Hematopoietic progenitor kinase 1 is a negative regulator of dendritic cell activation
-
Alzabin S, Bhardwaj N, Kiefer F, Sawasdikosol S, Burakoff S. Hematopoietic progenitor kinase 1 is a negative regulator of dendritic cell activation. J Immunol 182: 6187-6194, 2009.
-
(2009)
J Immunol
, vol.182
, pp. 6187-6194
-
-
Alzabin, S.1
Bhardwaj, N.2
Kiefer, F.3
Sawasdikosol, S.4
Burakoff, S.5
-
5
-
-
0030836865
-
SH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1
-
Anafi M, Kiefer F, Gish GD, Mbamalu G, Iscove NN, Pawson T. SH2/SH3 adaptor proteins can link tyrosine kinases to a Ste20-related protein kinase, HPK1. J Biol Chem 272: 27804-27811, 1997.
-
(1997)
J Biol Chem
, vol.272
, pp. 27804-27811
-
-
Anafi, M.1
Kiefer, F.2
Gish, G.D.3
Mbamalu, G.4
Iscove, N.N.5
Pawson, T.6
-
6
-
-
50049086910
-
The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling
-
Anaieva O, Darragh J, Johansen C, Carr JM, McIlrath J, Park JM, Wingate A, Monk CE, Toth R, Santos SG, Iverson L, Arthur JSC. The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling. Nat Immunol 9: 1028-1036, 2008.
-
(2008)
Nat Immunol
, vol.9
, pp. 1028-1036
-
-
Anaieva, O.1
Darragh, J.2
Johansen, C.3
Carr, J.M.4
McIlrath, J.5
Park, J.M.6
Wingate, A.7
Monk, C.E.8
Toth, R.9
Santos, S.G.10
Iverson, L.11
Arthur, J.S.C.12
-
7
-
-
0032530455
-
Tumor necrosis factor receptor-associated factors (TRAFs): A family of adapter proteins that regulates life and death
-
Arch RH, Gedrich RW, Thompson CB. Tumor necrosis factor receptor-associated factors (TRAFs): a family of adapter proteins that regulates life and death. Genes Dev 12: 2821-2830, 2000.
-
(2000)
Genes Dev
, vol.12
, pp. 2821-2830
-
-
Arch, R.H.1
Gedrich, R.W.2
Thompson, C.B.3
-
8
-
-
0037392942
-
The specificities of protein kinase inhibitors: An update
-
Bain J, McLauchlan H, Elliott M, Cohen P. The specificities of protein kinase inhibitors: an update. Biochem J 371: 199-204, 2003.
-
(2003)
Biochem J
, vol.371
, pp. 199-204
-
-
Bain, J.1
McLauchlan, H.2
Elliott, M.3
Cohen, P.4
-
9
-
-
36549040859
-
The selectivity of protein kinase inhibitors: A further update
-
Bain J, Plater L, Elliott N, Shpiro N, Hastie CJ, McLauchlan H, Klevernic I, Arthur JS, Alessi DR, Cohen P. The selectivity of protein kinase inhibitors: a further update. Biochem J 408: 297-315, 2007.
-
(2007)
Biochem J
, vol.408
, pp. 297-315
-
-
Bain, J.1
Plater, L.2
Elliott, N.3
Shpiro, N.4
Hastie, C.J.5
McLauchlan, H.6
Klevernic, I.7
Arthur, J.S.8
Alessi, D.R.9
Cohen, P.10
-
10
-
-
0033563101
-
Signaling by proinflammatory cytokines: Oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino terminal effector domain
-
Baud V, Liu Zg, Bennett B, Suzuki N, Xia Y, Karin M. Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino terminal effector domain. Genes Dev 13:1297-1308, 1999.
-
(1999)
Genes Dev
, vol.13
, pp. 1297-1308
-
-
Baud, V.1
Liu, Z.G.2
Bennett, B.3
Suzuki, N.4
Xia, Y.5
Karin, M.6
-
11
-
-
0033966557
-
Nck interacting Ste20 kinase couples Eph receptors to c-Jun N-terminal kinase and integrin activation
-
Becker E, Huynh-Do U, Holland S, Pawson T, Daniel TO, Skolnik EY. Nck interacting Ste20 kinase couples Eph receptors to c-Jun N-terminal kinase and integrin activation. Mol Cell Biol 20: 1537-1545, 2000.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 1537-1545
-
-
Becker, E.1
Huynh-Do, U.2
Holland, S.3
Pawson, T.4
Daniel, T.O.5
Skolnik, E.Y.6
-
12
-
-
6344264987
-
Lipopolysaccharide activation of the TPL-2/MAP2K/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IκB kinase-induced proteolysis of NF-κB1 p105
-
Beinke S, Robinson MJ, Hugunin M, Ley SC. Lipopolysaccharide activation of the TPL-2/MAP2K/extracellular signal-regulated kinase mitogen-activated protein kinase cascade is regulated by IκB kinase-induced proteolysis of NF-κB1 p105. Mol Cell Biol 24: 9658-9667, 2004.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 9658-9667
-
-
Beinke, S.1
Robinson, M.J.2
Hugunin, M.3
Ley, S.C.4
-
13
-
-
77950532905
-
Hypothalamic and pituitary c-Jun N-terminal kinase 1 signaling coordinately regulates glucose metabolism
-
Belgardt BF, Mauer J, Wunderlich FT, Ernst MB, Pal M, Spohn G, Brönneke HS, Brodesser S, Hampel B, Schauss AC, Brüning JC. Hypothalamic and pituitary c-Jun N-terminal kinase 1 signaling coordinately regulates glucose metabolism. Proc Natl Acad Sci USA 107: 6028-6033, 2010.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 6028-6033
-
-
Belgardt, B.F.1
Mauer, J.2
Wunderlich, F.T.3
Ernst, M.B.4
Pal, M.5
Spohn, G.6
Brönneke, H.S.7
Brodesser, S.8
Hampel, B.9
Schauss, A.C.10
Brüning, J.C.11
-
14
-
-
0028806565
-
Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2
-
Ben-Levy R, Leighton IA, Doza YN, Attwood P, Morrice N, Marshall CJ, Cohen P. Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2. EMBO J 14: 5920-5930, 1995.
-
(1995)
EMBO J
, vol.14
, pp. 5920-5930
-
-
Ben-Levy, R.1
Leighton, I.A.2
Doza, Y.N.3
Attwood, P.4
Morrice, N.5
Marshall, C.J.6
Cohen, P.7
-
15
-
-
0037954572
-
Signalling specificity of Ser/Thr protein kinases through docking-site-mediated interactions
-
Biondi RM, Nebreda AR. Signalling specificity of Ser/Thr protein kinases through docking-site-mediated interactions. Biochem J 372: 1-13, 2003.
-
(2003)
Biochem J
, vol.372
, pp. 1-13
-
-
Biondi, R.M.1
Nebreda, A.R.2
-
16
-
-
0029913457
-
Molecular cloning of mitogen activated protein/ERK kinase kinases (MEKK) 2 and 3
-
Blank JL, Gerwins P, Elliot EM, Sather S, Johnson GL. Molecular cloning of mitogen activated protein/ERK kinase kinases (MEKK) 2 and 3. J Biol Chem 271: 5361-5368, 1996.
-
(1996)
J Biol Chem
, vol.271
, pp. 5361-5368
-
-
Blank, J.L.1
Gerwins, P.2
Elliot, E.M.3
Sather, S.4
Johnson, G.L.5
-
17
-
-
0026029808
-
Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA binding activity
-
Boyle WJ, Smeal T, Defize LH, Angel P, Woodgett JR, Karin M, Hunter T. Activation of protein kinase C decreases phosphorylation of c-Jun at sites that negatively regulate its DNA binding activity. Cell 64: 573-584, 1991.
-
(1991)
Cell
, vol.64
, pp. 573-584
-
-
Boyle, W.J.1
Smeal, T.2
Defize, L.H.3
Angel, P.4
Woodgett, J.R.5
Karin, M.6
Hunter, T.7
-
18
-
-
17644373073
-
Role of MLK3 in the regulation of mitogen-activated protein kinase signaling cascades
-
Brancho D, Ventura JJ, Jaeschke A, Doran B, Flavell RA, Davis RJ. Role of MLK3 in the regulation of mitogen-activated protein kinase signaling cascades. Mol Cell Biol 25: 3670-3681, 2005.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 3670-3681
-
-
Brancho, D.1
Ventura, J.J.2
Jaeschke, A.3
Doran, B.4
Flavell, R.A.5
Davis, R.J.6
-
19
-
-
65449115788
-
Targeting of immune signaling networks by bacterial pathogens
-
Brodsky IE, Medzhitov R. Targeting of immune signaling networks by bacterial pathogens. Nat Cell Biol 11: 521-526, 2009.
-
(2009)
Nat Cell Biol
, vol.11
, pp. 521-526
-
-
Brodsky, I.E.1
Medzhitov, R.2
-
20
-
-
0028786020
-
A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases
-
Burbelo PD, Drechsel D, Hall A. A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases. J Biol Chem 270: 29071-29074, 1995.
-
(1995)
J Biol Chem
, vol.270
, pp. 29071-29074
-
-
Burbelo, P.D.1
Drechsel, D.2
Hall, A.3
-
21
-
-
52049088725
-
The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases)
-
Buxade M, Parra-Palau JL, Proud CG. The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases). Front Biosci 13: 5359-5373, 2008.
-
(2008)
Front Biosci
, vol.13
, pp. 5359-5373
-
-
Buxade, M.1
Parra-Palau, J.L.2
Proud, C.G.3
-
22
-
-
0030755579
-
The regulation of anoikis: MEKK-1 activation requires cleavage by caspases
-
Cardone MH, Salveson GS, Widmann C, Johnson G, Frisch S. The regulation of anoikis: MEKK-1 activation requires cleavage by caspases. Cell 90: 315-323, 1997.
-
(1997)
Cell
, vol.90
, pp. 315-323
-
-
Cardone, M.H.1
Salveson, G.S.2
Widmann, C.3
Johnson, G.4
Frisch, S.5
-
23
-
-
0037341276
-
Potential role of p38 in the downregulation of GLUT4 expression
-
Carlson CJ, Koterski S, Sciotti RJ, Braillard Poccard G, Rondinone CM. Potential role of p38 in the downregulation of GLUT4 expression. Diabetes 52: 634-641, 2003.
-
(2003)
Diabetes
, vol.52
, pp. 634-641
-
-
Carlson, C.J.1
Koterski, S.2
Sciotti, R.J.3
Braillard Poccard, G.4
Rondinone, C.M.5
-
24
-
-
0028793798
-
Induction of c-fos expression through JNKmediated TCF/Elk-1 phosphorylation
-
Cavigelli M, Dolfi F, Claret FX, Karin M. Induction of c-fos expression through JNKmediated TCF/Elk-1 phosphorylation. EMBO J 14: 5957-5964, 1995.
-
(1995)
EMBO J
, vol.14
, pp. 5957-5964
-
-
Cavigelli, M.1
Dolfi, F.2
Claret, F.X.3
Karin, M.4
-
25
-
-
0030902506
-
Tpl-2 is an oncogenic kinase that is activated by carboxyterminal truncation
-
Ceci JD, Patriotis CP, Tsatsanis C, Makris AM, Kovatch R, Swing DA, Jenkins NA, Tsichlis PN, Copeland NG. Tpl-2 is an oncogenic kinase that is activated by carboxyterminal truncation. Genes Dev 11: 688-700, 1997.
-
(1997)
Genes Dev
, vol.11
, pp. 688-700
-
-
Ceci, J.D.1
Patriotis, C.P.2
Tsatsanis, C.3
Makris, A.M.4
Kovatch, R.5
Swing, D.A.6
Jenkins, N.A.7
Tsichlis, P.N.8
Copeland, N.G.9
-
26
-
-
79953778211
-
2-terminal kinase for Ras-initiated tumor formation
-
2-terminal kinase for Ras-initiated tumor formation. Mol Cell Biol 31: 1565-1576, 2011.
-
(2011)
Mol Cell Biol
, vol.31
, pp. 1565-1576
-
-
Cellurale, C.1
Sabio, G.2
Kennedy, N.J.3
Das, M.4
Barlow, M.5
Sandy, P.6
Jacks, T.7
Davis, R.J.8
-
27
-
-
0036143713
-
Direct activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2
-
Chadee DN, Yuasa T, Kyriakis JM. Direct activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein TRAF2. Mol Cell Biol 22: 737-749, 2002.
-
(2002)
Mol Cell Biol
, vol.22
, pp. 737-749
-
-
Chadee, D.N.1
Yuasa, T.2
Kyriakis, J.M.3
-
28
-
-
0346037264
-
JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins
-
Chang L, Jones Y, Ellisman MH, Goldstein LS, Karin M. JNK1 is required for maintenance of neuronal microtubules and controls phosphorylation of microtubule-associated proteins. Dev Cell 4: 521-533, 2003.
-
(2003)
Dev Cell
, vol.4
, pp. 521-533
-
-
Chang, L.1
Jones, Y.2
Ellisman, M.H.3
Goldstein, L.S.4
Karin, M.5
-
29
-
-
79951768259
-
The kinases MEKK2 and MEKK3 regulate transforming growth factor-β-mediated helper T cell differentiation
-
Chang X, Liu F, Wang X, Lin A, Zhao H, Su B. The kinases MEKK2 and MEKK3 regulate transforming growth factor-β-mediated helper T cell differentiation. Immunity 34: 201-212, 2011.
-
(2011)
Immunity
, vol.34
, pp. 201-212
-
-
Chang, X.1
Liu, F.2
Wang, X.3
Lin, A.4
Zhao, H.5
Su, B.6
-
31
-
-
0030041536
-
Persistent activation of c-Jun N-terminal kinase-1 (JNK1) in γ radiation induced apoptosis
-
Chen YR, Meyer CF, Tan TH. Persistent activation of c-Jun N-terminal kinase-1 (JNK1) in γ radiation induced apoptosis. J Biol Chem 271: 631-634, 1996.
-
(1996)
J Biol Chem
, vol.271
, pp. 631-634
-
-
Chen, Y.R.1
Meyer, C.F.2
Tan, T.H.3
-
32
-
-
0033215189
-
Isolation of the protein kinase TAO2 and identification of its mitogen-activated protein kinase/extracellular signal-regulated kinase kinase binding domain
-
Chen Z, Hutchinson M, Cobb MH. Isolation of the protein kinase TAO2 and identification of its mitogen-activated protein kinase/extracellular signal-regulated kinase kinase binding domain. J Biol Chem 274: 28803-28807, 1999.
-
(1999)
J Biol Chem
, vol.274
, pp. 28803-28807
-
-
Chen, Z.1
Hutchinson, M.2
Cobb, M.H.3
-
33
-
-
0035282334
-
Mammalian MAP kinase signaling cascades
-
Cheng L, Karin M. Mammalian MAP kinase signaling cascades. Nature 410: 37-40, 2001.
-
(2001)
Nature
, vol.410
, pp. 37-40
-
-
Cheng, L.1
Karin, M.2
-
34
-
-
1542314841
-
TAB3, a new binding partner of the protein kinase TAK1
-
Cheung PC, Nebreda AR, Cohen P. TAB3, a new binding partner of the protein kinase TAK1. Biochem J 378: 27-34, 2004.
-
(2004)
Biochem J
, vol.378
, pp. 27-34
-
-
Cheung, P.C.1
Nebreda, A.R.2
Cohen, P.3
-
35
-
-
2342486760
-
GADD45β/GADD45γ and MEKK4 comprise a genetic pathway mediating STAT4-independent IFN-γ production in T cells
-
Chi H, Lu B, Takekawa M, Davis RJ, Flavell RA. GADD45β/GADD45γ and MEKK4 comprise a genetic pathway mediating STAT4-independent IFN-γ production in T cells. EMBO J 23: 1576-1586, 2004.
-
(2004)
EMBO J
, vol.23
, pp. 1576-1586
-
-
Chi, H.1
Lu, B.2
Takekawa, M.3
Davis, R.J.4
Flavell, R.A.5
-
36
-
-
0030706186
-
Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway
-
Chow CW, Rincón M, Cavanagh J, Dickens M, Davis RJ. Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway. Science 278: 1638-1641, 1997.
-
(1997)
Science
, vol.278
, pp. 1638-1641
-
-
Chow, C.W.1
Rincón, M.2
Cavanagh, J.3
Dickens, M.4
Davis, R.J.5
-
37
-
-
0033931374
-
2-terminal kinase inhibits targeting of the protein phosphatase calcineurin to NFATc1
-
2-terminal kinase inhibits targeting of the protein phosphatase calcineurin to NFATc1. Mol Cell Biol 20: 5227-5234, 2000.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 5227-5234
-
-
Chow, C.W.1
Dong, C.2
Flavell, R.A.3
Davis, R.J.4
-
38
-
-
0029587224
-
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
-
Cross DAE, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378: 785-789, 1995.
-
(1995)
Nature
, vol.378
, pp. 785-789
-
-
Cross, D.A.E.1
Alessi, D.R.2
Cohen, P.3
Andjelkovich, M.4
Hemmings, B.A.5
-
39
-
-
63849239758
-
Post-transcriptional gene regulation by MAP kinases via AU-rich elements
-
Clark A, Dean J, Tudor C, Saklatvala J. Post-transcriptional gene regulation by MAP kinases via AU-rich elements. Front Biosci 14: 847-871, 2009.
-
(2009)
Front Biosci
, vol.14
, pp. 847-871
-
-
Clark, A.1
Dean, J.2
Tudor, C.3
Saklatvala, J.4
-
40
-
-
77955474534
-
Immune interventions of human diseases through toll-like receptors
-
Coban C, Ishii KJ, Akira S. Immune interventions of human diseases through toll-like receptors. Adv Exp Med Biol 655: 63-80, 2009.
-
(2009)
Adv Exp Med Biol
, vol.655
, pp. 63-80
-
-
Coban, C.1
Ishii, K.J.2
Akira, S.3
-
41
-
-
42149159492
-
Wnt signaling: An essential regulator of cardiovascular differentiation, morphogenesis and progenitor self-renewal
-
Cohen ED, Tian Y, Morrisey EE. Wnt signaling: an essential regulator of cardiovascular differentiation, morphogenesis and progenitor self-renewal. Development 135: 789-798, 2008.
-
(2008)
Development
, vol.135
, pp. 789-798
-
-
Cohen, E.D.1
Tian, Y.2
Morrisey, E.E.3
-
42
-
-
63749083925
-
Targeting protein kinases for the development of anti-inflammatory drugs
-
Cohen P. Targeting protein kinases for the development of anti-inflammatory drugs. Curr Opin Cell Biol 21: 317-325, 2009.
-
(2009)
Curr Opin Cell Biol
, vol.21
, pp. 317-325
-
-
Cohen, P.1
-
43
-
-
72649098413
-
Irs1 serine 307 promotes insulin sensitivity in mice
-
Copps KD, Hancer NJ, Opare-Ado L, Qiw Walsh C W, White MF. Irs1 serine 307 promotes insulin sensitivity in mice. Cell Metab 11: 84-92, 2010.
-
(2010)
Cell Metab
, vol.11
, pp. 84-92
-
-
Copps, K.D.1
Hancer, N.J.2
Opare-Ado, L.3
Qiw Walsh, C.W.4
White, M.F.5
-
44
-
-
0029782176
-
Purification and cDNA cloning of SAPKK3, the major activator of RK/p38 in stress- and cytokinestimulated monocytes and epithelial cells
-
Cuenda A, Alonso G, Morrice N, Jones M, Meier R, Cohen P, Nebreda A. Purification and cDNA cloning of SAPKK3, the major activator of RK/p38 in stress- and cytokinestimulated monocytes and epithelial cells. EMBO J 15: 4156-4164, 1996.
-
(1996)
EMBO J
, vol.15
, pp. 4156-4164
-
-
Cuenda, A.1
Alonso, G.2
Morrice, N.3
Jones, M.4
Meier, R.5
Cohen, P.6
Nebreda, A.7
-
45
-
-
0031024646
-
Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38)
-
Cuenda A, Cohen P, Buee-Scherrer V, Goedert M. Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38). EMBO J 16: 296-305, 1997.
-
(1997)
EMBO J
, vol.16
, pp. 296-305
-
-
Cuenda, A.1
Cohen, P.2
Buee-Scherrer, V.3
Goedert, M.4
-
46
-
-
66349115622
-
Emerging role of Toll-like receptors in atherosclerosis
-
Curtiss LK, Tobias PS. Emerging role of Toll-like receptors in atherosclerosis. J Lipid Res 50: S340-S345, 2009.
-
(2009)
J Lipid Res
, vol.50
-
-
Curtiss, L.K.1
Tobias, P.S.2
-
47
-
-
0028902996
-
Stress-activated protein kinases bind directly to the delta domain of c-Jun in resting cells: Implications for repression of c-Jun function
-
Dai T, Rubie E, Franklin CC, Kraft A, Gillespie DA, Avruch J, Kyriakis JM, Woodgett JR. Stress-activated protein kinases bind directly to the delta domain of c-Jun in resting cells: implications for repression of c-Jun function. Oncogene 10: 849-855, 1995.
-
(1995)
Oncogene
, vol.10
, pp. 849-855
-
-
Dai, T.1
Rubie, E.2
Franklin, C.C.3
Kraft, A.4
Gillespie, D.A.5
Avruch, J.6
Kyriakis, J.M.7
Woodgett, J.R.8
-
48
-
-
38849086625
-
The JIP1 scaffold protein regulates axonal development in cortical neurons
-
Dajas-Bailador F, Jones EV, Whitmarsh AJ. The JIP1 scaffold protein regulates axonal development in cortical neurons. Curr Biol 18: 221-226, 2008.
-
(2008)
Curr Biol
, vol.18
, pp. 221-226
-
-
Dajas-Bailador, F.1
Jones, E.V.2
Whitmarsh, A.J.3
-
49
-
-
0031952597
-
Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK
-
Dalby KN, Morrice N, Caudwell FB, Avruch J, Cohen P. Identification of regulatory phosphorylation sites in mitogen-activated protein kinase (MAPK)-activated protein kinase-1a/p90rsk that are inducible by MAPK. J Biol Chem 273: 1496-1505, 1998.
-
(1998)
J Biol Chem
, vol.273
, pp. 1496-1505
-
-
Dalby, K.N.1
Morrice, N.2
Caudwell, F.B.3
Avruch, J.4
Cohen, P.5
-
50
-
-
0035341895
-
The Ste20 group kinases as regulators of MAP kinase cascades
-
Dan I, Watanabe NM, Kusumi A. The Ste20 group kinases as regulators of MAP kinase cascades. Trends Cell Biol 11: 220-230, 2001.
-
(2001)
Trends Cell Biol
, vol.11
, pp. 220-230
-
-
Dan, I.1
Watanabe, N.M.2
Kusumi, A.3
-
51
-
-
79952595097
-
The role of JNK in the development of hepatocellular carcinoma
-
Das M, Garlick DS, Greiner DL, Davis RJ. The role of JNK in the development of hepatocellular carcinoma. Genes Dev 25: 634-645, 2011.
-
(2011)
Genes Dev
, vol.25
, pp. 634-645
-
-
Das, M.1
Garlick, D.S.2
Greiner, D.L.3
Davis, R.J.4
-
52
-
-
21244463215
-
Tpl2/Cot signals activate ERK, JNK and NF-κB in a cell-type and stimulus-specific manner
-
Das S, Cho J, Lambertz I, Kelliher MA, Eliopoulos AG, Du K, Tsichlis PN. Tpl2/Cot signals activate ERK, JNK and NF-κB in a cell-type and stimulus-specific manner. J Biol Chem 280: 23748-23757, 2005.
-
(2005)
J Biol Chem
, vol.280
, pp. 23748-23757
-
-
Das, S.1
Cho, J.2
Lambertz, I.3
Kelliher, M.A.4
Eliopoulos, A.G.5
Du, K.6
Tsichlis, P.N.7
-
53
-
-
0034651732
-
Hsp25 and the p38 MAPK pathway are involved in differentiation of cardiomyocytes
-
Davidson SM, Morange M. Hsp25 and the p38 MAPK pathway are involved in differentiation of cardiomyocytes. Dev Biol 218: 146-160, 2000.
-
(2000)
Dev Biol
, vol.218
, pp. 146-160
-
-
Davidson, S.M.1
Morange, M.2
-
54
-
-
0034306450
-
Specificity and mechanism of action of some commonly used protein kinase inhibitors
-
Davies SP, Reddy H, Caivano M, Cohen P. Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J 351: 95-105, 2000.
-
(2000)
Biochem J
, vol.351
, pp. 95-105
-
-
Davies, S.P.1
Reddy, H.2
Caivano, M.3
Cohen, P.4
-
56
-
-
0032479983
-
Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, may mediate activation of CREB
-
Deak M, Clifton AD, Lucocq J, Alessi DR. Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, may mediate activation of CREB. EMBO J 17: 4426-4441, 1998.
-
(1998)
EMBO J
, vol.17
, pp. 4426-4441
-
-
Deak, M.1
Clifton, A.D.2
Lucocq, J.3
Alessi, D.R.4
-
57
-
-
0034746363
-
The 3' untranslated region of tumor necrosis factor alpha mRNA is a target of the mRNA-stabilizing factor HuR
-
Dean JL, Wait R, Mahtani KR, Sully G, Clark AR, Saklatvala J. The 3' untranslated region of tumor necrosis factor alpha mRNA is a target of the mRNA-stabilizing factor HuR. Mol Cell Biol 21: 721-730, 2001.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 721-730
-
-
Dean, J.L.1
Wait, R.2
Mahtani, K.R.3
Sully, G.4
Clark, A.R.5
Saklatvala, J.6
-
58
-
-
68149089761
-
The mammalian family of sterile 20p-like protein kinases
-
Delpire E. The mammalian family of sterile 20p-like protein kinases. Pflügers Arch 458: 953-967, 2009.
-
(2009)
Pflügers Arch
, vol.458
, pp. 953-967
-
-
Delpire, E.1
-
59
-
-
0028329953
-
JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun transactivation domain
-
Dérijard B, Hibi M,Wu LH, Barrett T, Su B, Deng T, Karin M, Davis RJ. JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun transactivation domain. Cell 76: 1025-1037, 1994.
-
(1994)
Cell
, vol.76
, pp. 1025-1037
-
-
Dérijard, B.1
Hibi, M.2
Wu, L.H.3
Barrett, T.4
Su, B.5
Deng, T.6
Karin, M.7
Davis, R.J.8
-
60
-
-
0028935974
-
Independent human MAP kinase signal transduction pathways defined by MEK and MKK isoforms
-
Dérijard B, Raingeaud J, Barrett T, Wu LH, Han J, Ulevitch RJ, Davis RJ. Independent human MAP kinase signal transduction pathways defined by MEK and MKK isoforms. Science 267: 682-685, 1995.
-
(1995)
Science
, vol.267
, pp. 682-685
-
-
Dérijard, B.1
Raingeaud, J.2
Barrett, T.3
Wu, L.H.4
Han, J.5
Ulevitch, R.J.6
Davis, R.J.7
-
61
-
-
24944438230
-
Consumption of a fat-rich diet activates a proinflammatory response and induced insulin resistance in the hypothalamus
-
De Souza CT, Araujo EP, Bordin S, Ashimine Zollner RL R, Boschero AC, Saad MJ, Velloso LA. Consumption of a fat-rich diet activates a proinflammatory response and induced insulin resistance in the hypothalamus. Endocrinology 146: 4192-4199, 2005.
-
(2005)
Endocrinology
, vol.146
, pp. 4192-4199
-
-
de Souza, C.T.1
Araujo, E.P.2
Bordin, S.3
Ashimine Zollner, R.L.R.4
Boschero, A.C.5
Saad, M.J.6
Velloso, L.A.7
-
62
-
-
33947378764
-
A novel pathway down-modulating T cell activation involves HPK-1-dependent recruitment of 14-3-3 proteins on SLP-76
-
Di Bartolo V, Bontagne B, Salek M, Hjungwirth B, Carrette F, Fourtane J, Sol-Foulon N, Michel F, Schwartz O, Lehmann WD, Acuto O. A novel pathway down-modulating T cell activation involves HPK-1-dependent recruitment of 14-3-3 proteins on SLP-76. J Exp Med 204: 681-691, 2007.
-
(2007)
J Exp Med
, vol.204
, pp. 681-691
-
-
Di Bartolo, V.1
Bontagne, B.2
Salek, M.3
Hjungwirth, B.4
Carrette, F.5
Fourtane, J.6
Sol-Foulon, N.7
Michel, F.8
Schwartz, O.9
Lehmann, W.D.10
Acuto, O.11
-
63
-
-
0030826412
-
A cytoplasmic inhibitor of the JNK signal transduction pathway
-
Dickens M, Rogers JS, Cavanagh J, Raitano A, Xia Z, Halpern JR, Greenberg ME, Sawyers CL, Davis RJ. A cytoplasmic inhibitor of the JNK signal transduction pathway. Science 277: 693-696, 1997.
-
(1997)
Science
, vol.277
, pp. 693-696
-
-
Dickens, M.1
Rogers, J.S.2
Cavanagh, J.3
Raitano, A.4
Xia, Z.5
Halpern, J.R.6
Greenberg, M.E.7
Sawyers, C.L.8
Davis, R.J.9
-
64
-
-
12644257580
-
Activation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinase
-
Diener K, Wang XS, Chen C, Meyer CF, Keesler G, Zukowski M, Tan TH, Yao Z. Activation of the c-Jun N-terminal kinase pathway by a novel protein kinase related to human germinal center kinase. Proc Natl Acad Sci USA 94: 9687-9692, 1997.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 9687-9692
-
-
Diener, K.1
Wang, X.S.2
Chen, C.3
Meyer, C.F.4
Keesler, G.5
Zukowski, M.6
Tan, T.H.7
Yao, Z.8
-
65
-
-
33645723895
-
The p38 mitogen-activated protein kinase signaling cascade in CD4 T cells
-
Dodeller F, Schulze-Koops H. The p38 mitogen-activated protein kinase signaling cascade in CD4 T cells. Arthritis Res Ther 8: 205, 2006.
-
(2006)
Arthritis Res Ther
, vol.8
, pp. 205
-
-
Dodeller, F.1
Schulze-Koops, H.2
-
66
-
-
0032509479
-
Defective T cell differentiation in the absence of JNK1
-
Dong C, Yang DD, Wysk M, Whitmarsh AJ, Davis RJ, Flavell RA. Defective T cell differentiation in the absence of JNK1. Science 282: 2092-2095, 1998.
-
(1998)
Science
, vol.282
, pp. 2092-2095
-
-
Dong, C.1
Yang, D.D.2
Wysk, M.3
Whitmarsh, A.J.4
Davis, R.J.5
Flavell, R.A.6
-
67
-
-
0034604093
-
JNK is required for effector T-cell function but not for T cell activation
-
Dong C, Yang DD, Tournier C, Whitmarsh AJ, Xu J, Davis RJ, Flavell RA. JNK is required for effector T-cell function but not for T cell activation. Nature 405: 91-94, 2000.
-
(2000)
Nature
, vol.405
, pp. 91-94
-
-
Dong, C.1
Yang, D.D.2
Tournier, C.3
Whitmarsh, A.J.4
Xu, J.5
Davis, R.J.6
Flavell, R.A.7
-
68
-
-
0027312371
-
Identification of a new family of human epithelial protein kinases containing two leucine/isoleucine-zipper domains
-
Dorow DS, Devereux L, Dietzsch E, De Kretser T. Identification of a new family of human epithelial protein kinases containing two leucine/isoleucine-zipper domains. Eur J Biochem 213: 701-710, 1993.
-
(1993)
Eur J Biochem
, vol.213
, pp. 701-710
-
-
Dorow, D.S.1
Devereux, L.2
Dietzsch, E.3
de Kretser, T.4
-
69
-
-
17744371331
-
TNF-α induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway
-
Dumitru CD, Ceci JD, Tsatsanis C, Kontoyiannis D, Stamatakis K, Lin JH, Patriotis C, Jenkins NA, Copeland NG, Kollias G, Tsichlis PN. TNF-α induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway. Cell 103: 1071-1083, 2000.
-
(2000)
Cell
, vol.103
, pp. 1071-1083
-
-
Dumitru, C.D.1
Ceci, J.D.2
Tsatsanis, C.3
Kontoyiannis, D.4
Stamatakis, K.5
Lin, J.H.6
Patriotis, C.7
Jenkins, N.A.8
Copeland, N.G.9
Kollias, G.10
Tsichlis, P.N.11
-
70
-
-
0032860232
-
WNT11 promotes cardiac tissue formation of early mesoderm
-
Eisenberg C, Eisenberg L. WNT11 promotes cardiac tissue formation of early mesoderm. Dev Dyn 216: 45-58, 1999.
-
(1999)
Dev Dyn
, vol.216
, pp. 45-58
-
-
Eisenberg, C.1
Eisenberg, L.2
-
71
-
-
0031036629
-
Direct activation of the stressactivated protein kinase and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein kinase/ERK kinase kinase 3 derivative
-
Ellinger-Ziegelbauer H, Brown K, Kelly K, Siebenlist U. Direct activation of the stressactivated protein kinase and extracellular signal-regulated protein kinase (ERK) pathways by an inducible mitogen-activated protein kinase/ERK kinase kinase 3 derivative. J Biol Chem 272: 2668-2674, 1997.
-
(1997)
J Biol Chem
, vol.272
, pp. 2668-2674
-
-
Ellinger-Ziegelbauer, H.1
Brown, K.2
Kelly, K.3
Siebenlist, U.4
-
72
-
-
0032961833
-
Cell cycle arrest and reversion of Rasinduced transformation by a conditionally activated form of mitogen-activated protein kinase kinase kinase 3
-
Ellinger-Ziegelbauer H, Kelly K, Siebenlist U. Cell cycle arrest and reversion of Rasinduced transformation by a conditionally activated form of mitogen-activated protein kinase kinase kinase 3. Mol Cell Biol 19: 3857-3868, 1999.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 3857-3868
-
-
Ellinger-Ziegelbauer, H.1
Kelly, K.2
Siebenlist, U.3
-
73
-
-
70349330009
-
MEKK1 binds HECT E3 ligase itch by its amino-terminal RING motif to regulate Th2 cytokine gene expression
-
Enzler T, Chang X, Facchinetti V, Melino G, Karin M, Su B, Gallagher E. MEKK1 binds HECT E3 ligase itch by its amino-terminal RING motif to regulate Th2 cytokine gene expression. J Immunol 183: 3831-3838, 2009.
-
(2009)
J Immunol
, vol.183
, pp. 3831-3838
-
-
Enzler, T.1
Chang, X.2
Facchinetti, V.3
Melino, G.4
Karin, M.5
Su, B.6
Gallagher, E.7
-
74
-
-
0025258896
-
Identification by mass spectrometry of threonine 97 in bovine myelin basic protein as a specific phosphorylation site for mitogen-activated protein kinase
-
Erickson AK, Payne DM, Martino PA, Rossomando AJ, Shabanowitz J, Weber MJ, Hunt DF, Sturgill TW. Identification by mass spectrometry of threonine 97 in bovine myelin basic protein as a specific phosphorylation site for mitogen-activated protein kinase. J Biol Chem 265: 19728-19735, 1990.
-
(1990)
J Biol Chem
, vol.265
, pp. 19728-19735
-
-
Erickson, A.K.1
Payne, D.M.2
Martino, P.A.3
Rossomando, A.J.4
Shabanowitz, J.5
Weber, M.J.6
Hunt, D.F.7
Sturgill, T.W.8
-
75
-
-
0032102902
-
Conversion of SB 203580- insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution
-
Eyers PA, Craxton M, Morrice N, Cohen P, Goedert M. Conversion of SB 203580- insensitive MAP kinase family members to drug-sensitive forms by a single amino-acid substitution. Chem Biol 5: 321-329, 1998.
-
(1998)
Chem Biol
, vol.5
, pp. 321-329
-
-
Eyers, P.A.1
Craxton, M.2
Morrice, N.3
Cohen, P.4
Goedert, M.5
-
76
-
-
0030875602
-
MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42
-
Fanger GR, Johnson NL, Johnson GL. MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42. EMBO J 16: 4961-4972, 1997.
-
(1997)
EMBO J
, vol.16
, pp. 4961-4972
-
-
Fanger, G.R.1
Johnson, N.L.2
Johnson, G.L.3
-
77
-
-
0032488910
-
14-3-3 proteins interact with specific MEK kinases
-
Fanger GR, Widmann C, Porter AC, Sather S, Johnson GL, Vaillancourt RR. 14-3-3 proteins interact with specific MEK kinases. J Biol Chem 273: 3476-3483, 1998.
-
(1998)
J Biol Chem
, vol.273
, pp. 3476-3483
-
-
Fanger, G.R.1
Widmann, C.2
Porter, A.C.3
Sather, S.4
Johnson, G.L.5
Vaillancourt, R.R.6
-
78
-
-
77955045781
-
The mitogen-activated protein kinase kinase 4 has a prooncogenic role in skin cancer
-
Finegan KG, Tournier C. The mitogen-activated protein kinase kinase 4 has a prooncogenic role in skin cancer. Cancer Res 70: 5797-5806, 2010.
-
(2010)
Cancer Res
, vol.70
, pp. 5797-5806
-
-
Finegan, K.G.1
Tournier, C.2
-
80
-
-
0028015872
-
Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27
-
Freshney NW, Rawlinson L, Guesdon F, Jones E, Cowley S, Hsuan J, Saklatvala J. Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27. Cell 78: 1039-1049, 1994.
-
(1994)
Cell
, vol.78
, pp. 1039-1049
-
-
Freshney, N.W.1
Rawlinson, L.2
Guesdon, F.3
Jones, E.4
Cowley, S.5
Hsuan, J.6
Saklatvala, J.7
-
81
-
-
0032705145
-
MEF2: A transcriptional target for signaling pathways controlling skeletal muscle growth and differentiation
-
Francisco JN, Eric N. MEF2: a transcriptional target for signaling pathways controlling skeletal muscle growth and differentiation. Curr Opin Cell Biol 11: 683-688, 1999.
-
(1999)
Curr Opin Cell Biol
, vol.11
, pp. 683-688
-
-
Francisco, J.N.1
Eric, N.2
-
82
-
-
0032697488
-
TNIK, a novel member of the terminal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton
-
Fu CA, Shen M, Huang BCB, Lasaga J, Payan DG, Luo Y. TNIK, a novel member of the terminal center kinase family that activates the c-Jun N-terminal kinase pathway and regulates the cytoskeleton. J Biol Chem 274: 30729-30737, 1999.
-
(1999)
J Biol Chem
, vol.274
, pp. 30729-30737
-
-
Fu, C.A.1
Shen, M.2
Huang, B.C.B.3
Lasaga, J.4
Payan, D.G.5
Luo, Y.6
-
83
-
-
0029829562
-
Phosphorylation-dependent targeting of c-Jun ubiquitination by Jun N-kinase
-
Fuchs SY, Dolan L, Davis RJ, Ronai Z. Phosphorylation-dependent targeting of c-Jun ubiquitination by Jun N-kinase. Oncogene 13: 1531-1535, 1996.
-
(1996)
Oncogene
, vol.13
, pp. 1531-1535
-
-
Fuchs, S.Y.1
Dolan, L.2
Davis, R.J.3
Ronai, Z.4
-
84
-
-
0037339991
-
Three mitogen-activated protein kinases inhibit insulin signaling by different mechanisms in 3T3-L1 adipocytes
-
Fujishiro M, Gotoh Y, Katagiri H, Sakoda H, Ogihara T, Anai M, Onishi Y, Ono H, Abe M, Shojima N, Fukushima Y, Kikuchi M, Oka Y, Asano T. Three mitogen-activated protein kinases inhibit insulin signaling by different mechanisms in 3T3-L1 adipocytes. Mol Endocrinol 17: 487-497, 2001.
-
(2001)
Mol Endocrinol
, vol.17
, pp. 487-497
-
-
Fujishiro, M.1
Gotoh, Y.2
Katagiri, H.3
Sakoda, H.4
Ogihara, T.5
Anai, M.6
Onishi, Y.7
Ono, H.8
Abe, M.9
Shojima, N.10
Fukushima, Y.11
Kikuchi, M.12
Oka, Y.13
Asano, T.14
-
85
-
-
0030977270
-
MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates
-
Fukunaga R, Hunter T. MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates. EMBO J 16: 1921-1933, 1997.
-
(1997)
EMBO J
, vol.16
, pp. 1921-1933
-
-
Fukunaga, R.1
Hunter, T.2
-
86
-
-
77956275419
-
eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression
-
Furic L, Rong L, Larsson O, Koumakpayi Yoshida K IH, Brueschke A, Petroulakis E, Robichaud N, Pollak M, Gaboury LA, Pandolfi PP, Saad F, Sonenberg N. eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression. Proc Natl Acad Sci USA 107: 14134-14139, 2010.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 14134-14139
-
-
Furic, L.1
Rong, L.2
Larsson, O.3
Koumakpayi Yoshida, K.I.H.4
Brueschke, A.5
Petroulakis, E.6
Robichaud, N.7
Pollak, M.8
Gaboury, L.A.9
Pandolfi, P.P.10
Saad, F.11
Sonenberg, N.12
-
87
-
-
33244471768
-
MAPKAP kinases-MKs-two's company, three's a crowd
-
Gaestel M. MAPKAP kinases-MKs-two's company, three's a crowd. Nat Rev Mol Cell Biol 7: 120-130, 2006.
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, pp. 120-130
-
-
Gaestel, M.1
-
88
-
-
33847002355
-
Kinase MEKK1 is required for CD40-dependent activation of the kinases JNK and p38, germinal center formation, B cell proliferation and antibody production
-
Gallagher E, Enzler T, Matsuzawa A, Anzelon-Mills A, Otero D, Holzer R, Janssen E, Gao M, Karin M. Kinase MEKK1 is required for CD40-dependent activation of the kinases JNK and p38, germinal center formation, B cell proliferation and antibody production. Nat Immunol 8: 57-63, 2007.
-
(2007)
Nat Immunol
, vol.8
, pp. 57-63
-
-
Gallagher, E.1
Enzler, T.2
Matsuzawa, A.3
Anzelon-Mills, A.4
Otero, D.5
Holzer, R.6
Janssen, E.7
Gao, M.8
Karin, M.9
-
89
-
-
0028340349
-
Identification and characterization of SPRK, a novel src-homology 3 domain-containing proline-rich kinase with serine/threonine kinase activity
-
Gallo KA, Mark MR, Scadden DT, Wang Z, Gu Q, Godowski PJ. Identification and characterization of SPRK, a novel src-homology 3 domain-containing proline-rich kinase with serine/threonine kinase activity. J Biol Chem 269: 15092-15100, 1994.
-
(1994)
J Biol Chem
, vol.269
, pp. 15092-15100
-
-
Gallo, K.A.1
Mark, M.R.2
Scadden, D.T.3
Wang, Z.4
Gu, Q.5
Godowski, P.J.6
-
90
-
-
0036731701
-
Mixed-lineage kianse control of JNK and p38 pathways
-
Gallo KA, Johnson GL. Mixed-lineage kianse control of JNK and p38 pathways. Nat Rev Mol Cell Biol 3: 663-672, 2002.
-
(2002)
Nat Rev Mol Cell Biol
, vol.3
, pp. 663-672
-
-
Gallo, K.A.1
Johnson, G.L.2
-
91
-
-
0032499687
-
SEK1 deficiency reveals mitogen-activated protein kinase cascade crossregulation and leads to abnormal hepatogenesis
-
Ganiatsas S, Kwee L, Fujiwara Y, Perkins A, Ikeda T, Labow MA, Zon LI. SEK1 deficiency reveals mitogen-activated protein kinase cascade crossregulation and leads to abnormal hepatogenesis. Proc Natl Acad Sci USA 95: 6881-6886, 1998.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 6881-6886
-
-
Ganiatsas, S.1
Kwee, L.2
Fujiwara, Y.3
Perkins, A.4
Ikeda, T.5
Labow, M.A.6
Zon, L.I.7
-
92
-
-
5044225158
-
Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase itch
-
Gao M, Labuda T, Xia Y, Gallagher E, Fang D, Liu YC, Karin M. Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase itch. Science 306: 271-275, 2004.
-
(2004)
Science
, vol.306
, pp. 271-275
-
-
Gao, M.1
Labuda, T.2
Xia, Y.3
Gallagher, E.4
Fang, D.5
Liu, Y.C.6
Karin, M.7
-
93
-
-
0037083375
-
MAPKK-independent activation of p38α mediated by TAB1-dependent autophosphorylation of p38α
-
Ge B, Gram H, Di Padova F, Huang B, New L, Ulevitch RJ, Luo Y, Han J. MAPKK-independent activation of p38α mediated by TAB1-dependent autophosphorylation of p38α. Science 295: 1291-1294, 2002.
-
(2002)
Science
, vol.295
, pp. 1291-1294
-
-
Ge, B.1
Gram, H.2
Di Padova, F.3
Huang, B.4
New, L.5
Ulevitch, R.J.6
Luo, Y.7
Han, J.8
-
94
-
-
34247367950
-
In vivo functions of mitogen-activated protein kinases: Conclusions from knock-in and knockout mice
-
Gerits N, Kostenko S, Moens U. In vivo functions of mitogen-activated protein kinases: conclusions from knock-in and knockout mice. Transgenic Res 16: 281-314, 2007.
-
(2007)
Transgenic Res
, vol.16
, pp. 281-314
-
-
Gerits, N.1
Kostenko, S.2
Moens, U.3
-
95
-
-
0030934694
-
Cloning of a novel mitogen-activated protein kinasekinase- kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway
-
Gerwins P, Blank JL, Johnson GL. Cloning of a novel mitogen-activated protein kinasekinase- kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway. J Biol Chem 272: 8288-8295, 1997.
-
(1997)
J Biol Chem
, vol.272
, pp. 8288-8295
-
-
Gerwins, P.1
Blank, J.L.2
Johnson, G.L.3
-
96
-
-
0026695645
-
Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter
-
Gille H, Sharrocks AD, Shaw PE. Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter. Nature 358: 414-417, 1992.
-
(1992)
Nature
, vol.358
, pp. 414-417
-
-
Gille, H.1
Sharrocks, A.D.2
Shaw, P.E.3
-
97
-
-
0028875388
-
Hemipterous encodes a novel Drosophila MAP kinase kinase, required for epithelial cell sheet movement
-
Glise B, Bourbon H, Noselli S. hemipterous encodes a novel Drosophila MAP kinase kinase, required for epithelial cell sheet movement. Cell 83: 451-461, 1995.
-
(1995)
Cell
, vol.83
, pp. 451-461
-
-
Glise, B.1
Bourbon, H.2
Noselli, S.3
-
98
-
-
0030927106
-
Activation of the novel stressactivated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases
-
Goedert M, Cuenda A, Craxton M, Jakes R, Cohen P. Activation of the novel stressactivated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases. EMBO J 16: 3563-3571, 1997.
-
(1997)
EMBO J
, vol.16
, pp. 3563-3571
-
-
Goedert, M.1
Cuenda, A.2
Craxton, M.3
Jakes, R.4
Cohen, P.5
-
99
-
-
33747339465
-
Wnt signaling: Multiple pathways, multiple receptors, and multiple transcription factors
-
Gordon MD, Nusse R. Wnt signaling: multiple pathways, multiple receptors, and multiple transcription factors. J Biol Chem 281: 22429-22433, 2006.
-
(2006)
J Biol Chem
, vol.281
, pp. 22429-22433
-
-
Gordon, M.D.1
Nusse, R.2
-
100
-
-
0032504189
-
Reactive oxygen species- and dimerization-induced activation of apoptosis signal-regulating kinase 1 in tumor necrosis factor-α signal transduction
-
Gotoh Y, Cooper JA. Reactive oxygen species- and dimerization-induced activation of apoptosis signal-regulating kinase 1 in tumor necrosis factor-α signal transduction. J Biol Chem 273: 17477-17482, 1998.
-
(1998)
J Biol Chem
, vol.273
, pp. 17477-17482
-
-
Gotoh, Y.1
Cooper, J.A.2
-
101
-
-
10744227768
-
Acquisition of sensitivity of stress-activated protein kinases to the p38 inhibitor, SB 203580, by alteration of one or more amino acids within the ATP binding pocket
-
Gum RJ, McLaughlin MM, Kumar S, Wang Z, Bower MJ, Lee JC, Adams JL, Livi GP, Goldsmith EJ, Young PR. Acquisition of sensitivity of stress-activated protein kinases to the p38 inhibitor, SB 203580, by alteration of one or more amino acids within the ATP binding pocket. J Biol Chem 273: 15605-15610, 1998.
-
(1998)
J Biol Chem
, vol.273
, pp. 15605-15610
-
-
Gum, R.J.1
McLaughlin, M.M.2
Kumar, S.3
Wang, Z.4
Bower, M.J.5
Lee, J.C.6
Adams, J.L.7
Livi, G.P.8
Goldsmith, E.J.9
Young, P.R.10
-
102
-
-
0028905076
-
Transcription factor ATF2 regulation by the JNK signal transduction pathway
-
Gupta S, Campbell D, Dérijard B, Davis RJ. Transcription factor ATF2 regulation by the JNK signal transduction pathway. Science 267: 389-393, 1995.
-
(1995)
Science
, vol.267
, pp. 389-393
-
-
Gupta, S.1
Campbell, D.2
Dérijard, B.3
Davis, R.J.4
-
104
-
-
0027936755
-
A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells
-
Han J, Lee J-D, Bibbs L, Ulevitch RJ. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 265: 808-811, 1994.
-
(1994)
Science
, vol.265
, pp. 808-811
-
-
Han, J.1
Lee, J.-D.2
Bibbs, L.3
Ulevitch, R.J.4
-
105
-
-
0005403737
-
MEF2C participates in inflammatory responses via p38-mediated activation
-
Han J, Jiang Y, Li Z, Kravchenko VV, Ulevitch RJ. MEF2C participates in inflammatory responses via p38-mediated activation. Nature 386. 563-566, 1997.
-
(1997)
Nature
, vol.386
, pp. 563-566
-
-
Han, J.1
Jiang, Y.2
Li, Z.3
Kravchenko, V.V.4
Ulevitch, R.J.5
-
106
-
-
77249111224
-
Apoptosis signal-regulating kinase 1 regulates colitis and colitis-associated tumorigenesis by the innate immune responses
-
Hayakawa Y, Hirata Y, Nakagawa H, Sakamoto K, Hikiba Y, Otsuka M, Ijichi H, Ikenoue T, Tateishi K, Akanuma M, Ogura K, Yoshida H, Ichijo H, Omata M, Maeda S. Apoptosis signal-regulating kinase 1 regulates colitis and colitis-associated tumorigenesis by the innate immune responses. Gastroenterology 138: 1055-1067, 2009.
-
(2009)
Gastroenterology
, vol.138
, pp. 1055-1067
-
-
Hayakawa, Y.1
Hirata, Y.2
Nakagawa, H.3
Sakamoto, K.4
Hikiba, Y.5
Otsuka, M.6
Ijichi, H.7
Ikenoue, T.8
Tateishi, K.9
Akanuma, M.10
Ogura, K.11
Yoshida, H.12
Ichijo, H.13
Omata, M.14
Maeda, S.15
-
107
-
-
79551663938
-
Apoptosis signal-regulating kinase 1 and cyclin D1 compose a positive feedback loop contributing to tumor growth in gastric cancer
-
Hayakawa Y, Hirata Y, Nagakawa H, Sakamoto K, Hikiba Y, Kinoshita H, Nakata W, Takahashi R, Tateishi K, Tada M, Akanuma M, Yoshida H, Takeda K, Ichijo H, Omata M, Maeda S, Koike K. Apoptosis signal-regulating kinase 1 and cyclin D1 compose a positive feedback loop contributing to tumor growth in gastric cancer. Proc Natl Acad Sci USA 108: 780-785, 2011.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 780-785
-
-
Hayakawa, Y.1
Hirata, Y.2
Nagakawa, H.3
Sakamoto, K.4
Hikiba, Y.5
Kinoshita, H.6
Nakata, W.7
Takahashi, R.8
Tateishi, K.9
Tada, M.10
Akanuma, M.11
Yoshida, H.12
Takeda, K.13
Ichijo, H.14
Omata, M.15
Maeda, S.16
Koike, K.17
-
108
-
-
0028985079
-
MAP kinase pathways in yeast: For mating and more
-
Herskowitz I. MAP kinase pathways in yeast: for mating and more. Cell 80: 187-197, 1995.
-
(1995)
Cell
, vol.80
, pp. 187-197
-
-
Herskowitz, I.1
-
109
-
-
0030918591
-
MST/ MLK2, a member of the mixed lineage kinase family, directly phosphorylates and activates SEK1, an activator of c-Jun N-terminal kinase/stress-activated protein kinase
-
Hirai Si Katoh M, Terada M, Kyriakis JM, Zon LI, Rana A, Avruch J, Ohno S. MST/ MLK2, a member of the mixed lineage kinase family, directly phosphorylates and activates SEK1, an activator of c-Jun N-terminal kinase/stress-activated protein kinase. J Biol Chem 272: 15167-15173, 1997.
-
(1997)
J Biol Chem
, vol.272
, pp. 15167-15173
-
-
Hirai Si Katoh, M.1
Terada, M.2
Kyriakis, J.M.3
Zon, L.I.4
Rana, A.5
Avruch, J.6
Ohno, S.7
-
110
-
-
0032571362
-
Differential activation of two JNK activators, MKK7 and SEK1, by MKN28-derived nonreceptor serine/threonine kinase/mixed lineage kinase 2
-
Hirai Si Noda K, Moriguchi T, Nishida E, Yamashita A, Deyama T, Fukuyama K, Ohno S. Differential activation of two JNK activators, MKK7 and SEK1, by MKN28-derived nonreceptor serine/threonine kinase/mixed lineage kinase 2. J Biol Chem 273: 7406-7412, 1998.
-
(1998)
J Biol Chem
, vol.273
, pp. 7406-7412
-
-
Hirai, S.1
Noda, K.2
Moriguchi, T.3
Nishida, E.4
Yamashita, A.5
Deyama, T.6
Fukuyama, K.7
Ohno, S.8
-
111
-
-
0037153158
-
A central role for JNK in obesity and insulin resistance
-
Hirosumi J, Tuncman G, Chang L, Görgün CZ, Uysal KT, Maeda K, Karin M, Hotamisligil G. A central role for JNK in obesity and insulin resistance. Nature 420: 334-337, 2002.
-
(2002)
Nature
, vol.420
, pp. 334-337
-
-
Hirosumi, J.1
Tuncman, G.2
Chang, L.3
Görgün, C.Z.4
Uysal, K.T.5
Maeda, K.6
Karin, M.7
Hotamisligil, G.8
-
112
-
-
33644753147
-
Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression, stability and binding to adenine/uridine-rich element
-
Hitti E, Iakovleva T, Brook M, Deppenmeier S, Gruber AD, Radzioch D, Clark AR, Blackshear PJ, Kotlyarov A, Gaestel M. Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression, stability and binding to adenine/uridine-rich element. Mol Cell Biol 26: 2399-2407, 2006.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 2399-2407
-
-
Hitti, E.1
Iakovleva, T.2
Brook, M.3
Deppenmeier, S.4
Gruber, A.D.5
Radzioch, D.6
Clark, A.R.7
Blackshear, P.J.8
Kotlyarov, A.9
Gaestel, M.10
-
113
-
-
0141483523
-
Transcriptional regulation by calcium, calcineurin and NFAT
-
Hogan PG, Chen L, Nardone J, Rao A. Transcriptional regulation by calcium, calcineurin and NFAT. Genes Dev 17: 2205-2232, 2003.
-
(2003)
Genes Dev
, vol.17
, pp. 2205-2232
-
-
Hogan, P.G.1
Chen, L.2
Nardone, J.3
Rao, A.4
-
114
-
-
0028143060
-
Identification, molecular cloning and characterization of dual leucine zipper bearing kinase
-
Holtzman LB, Merritt SE, Fan G. Identification, molecular cloning and characterization of dual leucine zipper bearing kinase. J Biol Chem 269: 30808-30817, 1994.
-
(1994)
J Biol Chem
, vol.269
, pp. 30808-30817
-
-
Holtzman, L.B.1
Merritt, S.E.2
Fan, G.3
-
115
-
-
0027459878
-
Adipose expression of tumor necrosis factor-α: Direct role in obesity-linked insulin resistance
-
Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-α: direct role in obesity-linked insulin resistance. Science 259: 87-91, 1993.
-
(1993)
Science
, vol.259
, pp. 87-91
-
-
Hotamisligil, G.S.1
Shargill, N.S.2
Spiegelman, B.M.3
-
117
-
-
0028031569
-
Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor α
-
Hotamisligil GS, Budavari A, Murray D, Spiegelman BM. Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor α. J Clin Invest 94: 1543-1549, 1994.
-
(1994)
J Clin Invest
, vol.94
, pp. 1543-1549
-
-
Hotamisligil, G.S.1
Budavari, A.2
Murray, D.3
Spiegelman, B.M.4
-
118
-
-
0030061922
-
IRS-1- mediated inhibition of insulin receptor tyrosine kinase activity in TNF-α and obesityinduced insulin resistance
-
Hotamisligil GS, Peraldi P, Budavari A, Ellis R, White MF, Spiegelman BM. IRS-1- mediated inhibition of insulin receptor tyrosine kinase activity in TNF-α and obesityinduced insulin resistance. Science 271: 665-668, 1996.
-
(1996)
Science
, vol.271
, pp. 665-668
-
-
Hotamisligil, G.S.1
Peraldi, P.2
Budavari, A.3
Ellis, R.4
White, M.F.5
Spiegelman, B.M.6
-
119
-
-
0029763450
-
Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade
-
Hu MCT, Qiu WR, Wang X, Meyer CF, Tan TH. Human HPK1, a novel human hematopoietic progenitor kinase that activates the JNK/SAPK kinase cascade. Genes Dev 10: 2251-2264, 1996.
-
(1996)
Genes Dev
, vol.10
, pp. 2251-2264
-
-
Hu, M.C.T.1
Qiu, W.R.2
Wang, X.3
Meyer, C.F.4
Tan, T.H.5
-
120
-
-
0346496017
-
Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3
-
Huang Q, Yang J, Lin Y, Walker C, Cheng J, Liu Zg, Su B. Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3. Nat Immunol 5: 98-103, 2004.
-
(2004)
Nat Immunol
, vol.5
, pp. 98-103
-
-
Huang, Q.1
Yang, J.2
Lin, Y.3
Walker, C.4
Cheng, J.5
Liu, Z.G.6
Su, B.7
-
121
-
-
34249334506
-
p38α suppresses normal and cancer cell proliferation by antagonizing the JNK-c-Jun pathway
-
Hui L, Bakiri L, Mairhorfer A, Schweifer N, Haslinger C, Kenner L, Komnenovic V, Scheuch H, Beug H, Wagner EF. p38α suppresses normal and cancer cell proliferation by antagonizing the JNK-c-Jun pathway. Nat Genet 39: 741-749, 2007.
-
(2007)
Nat Genet
, vol.39
, pp. 741-749
-
-
Hui, L.1
Bakiri, L.2
Mairhorfer, A.3
Schweifer, N.4
Haslinger, C.5
Kenner, L.6
Komnenovic, V.7
Scheuch, H.8
Beug, H.9
Wagner, E.F.10
-
122
-
-
57449109370
-
Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation
-
Hui L, Zatloukal K, Scheuch H, Stepniak E, Wagner EF. Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation. J Clin Invest 118: 3943-3953, 2008.
-
(2008)
J Clin Invest
, vol.118
, pp. 3943-3953
-
-
Hui, L.1
Zatloukal, K.2
Scheuch, H.3
Stepniak, E.4
Wagner, E.F.5
-
123
-
-
0031057892
-
Oxidative stress-induced actin reorganization mediated by the p38 mitogen-activated protein kinase/heat shock protein 27 pathway in vascular endothelial cells
-
Huot J, Houle F, Marceau F, Landry J. Oxidative stress-induced actin reorganization mediated by the p38 mitogen-activated protein kinase/heat shock protein 27 pathway in vascular endothelial cells. Circ Res 80: 383-392, 1997.
-
(1997)
Circ Res
, vol.80
, pp. 383-392
-
-
Huot, J.1
Houle, F.2
Marceau, F.3
Landry, J.4
-
124
-
-
0032582644
-
Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades
-
Hutchinson M, Berman KS, Cobb MH. Isolation of TAO1, a protein kinase that activates MEKs in stress-activated protein kinase cascades. J Biol Chem 273: 28625-28632.
-
J Biol Chem
, vol.273
, pp. 28625-28632
-
-
Hutchinson, M.1
Berman, K.S.2
Cobb, M.H.3
-
125
-
-
14444281569
-
Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways
-
Ichijo H, Nishida E, Irie K, ten Dijke P, Saitoh M, Moriguchi T, Takagi M, Matsumoto K, Miyazono K, Gotoh Y. Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science 275: 90-94, 1997.
-
(1997)
Science
, vol.275
, pp. 90-94
-
-
Ichijo, H.1
Nishida, E.2
Irie, K.3
ten Dijke, P.4
Saitoh, M.5
Moriguchi, T.6
Takagi, M.7
Matsumoto, K.8
Miyazono, K.9
Gotoh, Y.10
-
126
-
-
65449146296
-
ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis
-
Iriyama T, Takeda K, Nakamura H, Morimoto Y, Kuroiwa T, Mizukami J, Umeda T, Noguchi T, Naguro I, Nishitoh H, Saegusa K, Tobiume K, Homma T, Shimada Y, Tsuda H, Aiko S, Imoto Inazawa J I, Chida K, Kamei Y, Kozuma Taketani Y S, Matsuzawa A, Ichijo H. ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis. EMBO J 28: 843-853, 2009.
-
(2009)
EMBO J
, vol.28
, pp. 843-853
-
-
Iriyama, T.1
Takeda, K.2
Nakamura, H.3
Morimoto, Y.4
Kuroiwa, T.5
Mizukami, J.6
Umeda, T.7
Noguchi, T.8
Naguro, I.9
Nishitoh, H.10
Saegusa, K.11
Tobiume, K.12
Homma, T.13
Shimada, Y.14
Tsuda, H.15
Aiko, S.16
Imoto Inazawa, J.I.17
Chida, K.18
Kamei, Y.19
Kozuma Taketani, Y.S.20
Matsuzawa, A.21
Ichijo, H.22
more..
-
127
-
-
0346243941
-
Role of TAB2-related protein TAB3 in IL-1 and TNF signaling
-
Ishitani T, Takaesu G, Ninomiya-Tsuji J, Shibuya H, Gaynor RB, Matsumoto K. Role of TAB2-related protein TAB3 in IL-1 and TNF signaling. EMBO J 22: 6277-6288, 2003.
-
(2003)
EMBO J
, vol.22
, pp. 6277-6288
-
-
Ishitani, T.1
Takaesu, G.2
Ninomiya-Tsuji, J.3
Shibuya, H.4
Gaynor, R.B.5
Matsumoto, K.6
-
128
-
-
0032694245
-
JSAP1, a novel Jun N-terminal protein kinase (JNK)- binding protein that functions as a scaffold factor in the JNK signaling pathway
-
Ito M, Yoshioka K, Akechi M, Yamashita S, Takamatsu N, Sugiyama K, Hibi M, Nakabeppu Y, Shiba T, Yamamoto KI. JSAP1, a novel Jun N-terminal protein kinase (JNK)- binding protein that functions as a scaffold factor in the JNK signaling pathway. Mol Cell Biol 19: 7539-7548, 1999.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 7539-7548
-
-
Ito, M.1
Yoshioka, K.2
Akechi, M.3
Yamashita, S.4
Takamatsu, N.5
Sugiyama, K.6
Hibi, M.7
Nakabeppu, Y.8
Shiba, T.9
Yamamoto, K.I.10
-
129
-
-
34547219895
-
Metabolic stress signaling mediated by mixed lineage kinases
-
Jaeschke A, Davis RJ. Metabolic stress signaling mediated by mixed lineage kinases. Mol Cell 27: 498-508, 2007.
-
(2007)
Mol Cell
, vol.27
, pp. 498-508
-
-
Jaeschke, A.1
Davis, R.J.2
-
130
-
-
27944479854
-
Rho GTPases: Biochemistry and biology
-
Jaffe AB, Hall A. Rho GTPases: biochemistry and biology. Annu Rev Cell Dev Biol 21: 247-269, 2005.
-
(2005)
Annu Rev Cell Dev Biol
, vol.21
, pp. 247-269
-
-
Jaffe, A.B.1
Hall, A.2
-
131
-
-
0030901584
-
Convergence of MAP kinase pathways on the ternary complex factor Sap-1a
-
Janknecht R, Hunter T. Convergence of MAP kinase pathways on the ternary complex factor Sap-1a. EMBO J 16: 1620-1627, 1997.
-
(1997)
EMBO J
, vol.16
, pp. 1620-1627
-
-
Janknecht, R.1
Hunter, T.2
-
132
-
-
0029982565
-
Characterization of the structure and function of a new mitogen-activated protein kinase (p38β)
-
Jiang Y, Chen Li Z C, Guo W, Gegner JA, Lin S, Han J. Characterization of the structure and function of a new mitogen-activated protein kinase (p38β). J Biol Chem 271: 17920-17926, 1996.
-
(1996)
J Biol Chem
, vol.271
, pp. 17920-17926
-
-
Jiang, Y.1
Chen Li, Z.C.2
Guo, W.3
Gegner, J.A.4
Lin, S.5
Han, J.6
-
133
-
-
0030828701
-
Characterization of the structure and function of the fourth member of the p38 group mitogen-activated protein kinases, p38δ
-
Jiang Y, Gram H, Zhao M, New L, Gu J, Feng L, Di Padova F, Ulevitch RJ, Han J. Characterization of the structure and function of the fourth member of the p38 group mitogen-activated protein kinases, p38δ. J Biol Chem 272: 30122-30128, 1997.
-
(1997)
J Biol Chem
, vol.272
, pp. 30122-30128
-
-
Jiang, Y.1
Gram, H.2
Zhao, M.3
New, L.4
Gu, J.5
Feng, L.6
di Padova, F.7
Ulevitch, R.J.8
Han, J.9
-
134
-
-
10744220155
-
Identification of a human NF-κB activating protein TAB3
-
Jin G, Klika A, Callahan M, Faga B, Danzig J, Jiang Z, Li X, Stark GR, Harrington J, Sherf B. Identification of a human NF-κB activating protein TAB3. Proc Natl Acad Sci USA 101: 2028-2033, 2004.
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 2028-2033
-
-
Jin, G.1
Klika, A.2
Callahan, M.3
Faga, B.4
Danzig, J.5
Jiang, Z.6
Li, X.7
Stark, G.R.8
Harrington, J.9
Sherf, B.10
-
135
-
-
64049117360
-
Genetic disruption of p38α Tyr323 phosphorylation prevents T-cell receptor-mediated p38α activation and impairs interferon-γ production
-
Jirmanova L, Sarma DN, Jankovic D, Mittelstadt PR, Ashwell JD. Genetic disruption of p38α Tyr323 phosphorylation prevents T-cell receptor-mediated p38α activation and impairs interferon-γ production. Blood 113: 2229-2237, 2009.
-
(2009)
Blood
, vol.113
, pp. 2229-2237
-
-
Jirmanova, L.1
Sarma, D.N.2
Jankovic, D.3
Mittelstadt, P.R.4
Ashwell, J.D.5
-
136
-
-
79251479063
-
Defining MAPK interactomes
-
Johnson GL. Defining MAPK interactomes. ACS Chem Biol 6: 18-20, 2011.
-
(2011)
ACS Chem Biol
, vol.6
, pp. 18-20
-
-
Johnson, G.L.1
-
137
-
-
0028609209
-
JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation
-
Kallunki T, Su B, Tsigelny I, Sluss HK, Dérijard B, Moore G, Davis R, Karin M. JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation. Genes Dev 8: 2996-3007, 1994.
-
(1994)
Genes Dev
, vol.8
, pp. 2996-3007
-
-
Kallunki, T.1
Su, B.2
Tsigelny, I.3
Sluss, H.K.4
Dérijard, B.5
Moore, G.6
Davis, R.7
Karin, M.8
-
138
-
-
0030606319
-
c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions
-
Kallunki T, Deng T, Hibi M, Karin M. c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions. Cell 87: 929-939, 1996.
-
(1996)
Cell
, vol.87
, pp. 929-939
-
-
Kallunki, T.1
Deng, T.2
Hibi, M.3
Karin, M.4
-
139
-
-
0032731126
-
Nrk: A murine X-linked NIK (Nck-interacting kinase)-related kinase gene expressed in skeletal muscle
-
Kanai-Azuma M, Kanai Y, Okamoto M, Hayashi Y, Yonekawa H, Yazaki K. Nrk: a murine X-linked NIK (Nck-interacting kinase)-related kinase gene expressed in skeletal muscle. Mech Dev 89: 155-160, 1999.
-
(1999)
Mech Dev
, vol.89
, pp. 155-160
-
-
Kanai-Azuma, M.1
Kanai, Y.2
Okamoto, M.3
Hayashi, Y.4
Yonekawa, H.5
Yazaki, K.6
-
140
-
-
4344712350
-
TAB2 and TAB3 activate the NF-κB pathway through binding to polyubiquitin chains
-
Kanayama A, Seth RB, Sun L, Ea CK, Hong M, Shaito A, Chiu YH, Deng L, Chen ZJ. TAB2 and TAB3 activate the NF-κB pathway through binding to polyubiquitin chains. Mol Cell 15: 535-548, 2004.
-
(2004)
Mol Cell
, vol.15
, pp. 535-548
-
-
Kanayama, A.1
Seth, R.B.2
Sun, L.3
Ea, C.K.4
Hong, M.5
Shaito, A.6
Chiu, Y.H.7
Deng, L.8
Chen, Z.J.9
-
141
-
-
0028825748
-
Tumor necrosis factor α-induced phosphorylation of insulin receptor substrate-1 (IRS-1). Possible mechanism for suppression of insulin-stimulated tyrosine phosphorylation of IRS-1
-
Kanety H, Feinstein R, Papa MZ, Karasik A. Tumor necrosis factor α-induced phosphorylation of insulin receptor substrate-1 (IRS-1). Possible mechanism for suppression of insulin-stimulated tyrosine phosphorylation of IRS-1. J Biol Chem 270: 23780-23784, 1995.
-
(1995)
J Biol Chem
, vol.270
, pp. 23780-23784
-
-
Kanety, H.1
Feinstein, R.2
Papa, M.Z.3
Karasik, A.4
-
142
-
-
33748743740
-
Multiple activation mechanisms of p38 alpha mitogen-activated protein kinase
-
Kang YJ, Seit-Nebi A, Davis RJ, Han J. Multiple activation mechanisms of p38 alpha mitogen-activated protein kinase. J Biol Chem 281: 26225-26234, 2006.
-
(2006)
J Biol Chem
, vol.281
, pp. 26225-26234
-
-
Kang, Y.J.1
Seit-Nebi, A.2
Davis, R.J.3
Han, J.4
-
143
-
-
21344474327
-
From JNK to pay dirt: Jun kinases, their biochemistry, physiology and clinical importance
-
Karin M, Gallagher E. From JNK to pay dirt: jun kinases, their biochemistry, physiology and clinical importance. IUBMB Life 57: 283-295, 2005.
-
(2005)
IUBMB Life
, vol.57
, pp. 283-295
-
-
Karin, M.1
Gallagher, E.2
-
144
-
-
77956916650
-
POSH2 is a RING finger E3 ligase with Rac1 binding activity through a partial CRIB domain
-
Kärkkäinen S, van der Linden M, Renkema GH. POSH2 is a RING finger E3 ligase with Rac1 binding activity through a partial CRIB domain. FEBS Lett 584: 3867-3872, 2010.
-
(2010)
FEBS Lett
, vol.584
, pp. 3867-3872
-
-
Kärkkäinen, S.1
van der Linden, M.2
Renkema, G.H.3
-
145
-
-
0026496885
-
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
-
Kastan MB, Zhan Q, el-Diery WS, Carrier F, Jacks T, Walsh WV, Plunkett BS, Vogelstein B, Fornace AJ Jr. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell 71: 587-597, 1992.
-
(1992)
Cell
, vol.71
, pp. 587-597
-
-
Kastan, M.B.1
Zhan, Q.2
El-Diery, W.S.3
Carrier, F.4
Jacks, T.5
Walsh, W.V.6
Plunkett, B.S.7
Vogelstein, B.8
Fornace Jr., A.J.9
-
146
-
-
0028279796
-
Differential expression of a novel protein kinase in human B lymphocytes: Preferential localization in the germinal center
-
Katz P, Whalen G, Kehrl JH. Differential expression of a novel protein kinase in human B lymphocytes: preferential localization in the germinal center. J Biol Chem 269: 16802-16809, 1994.
-
(1994)
J Biol Chem
, vol.269
, pp. 16802-16809
-
-
Katz, P.1
Whalen, G.2
Kehrl, J.H.3
-
147
-
-
77951260924
-
The role of pattern-recognition receptors in innate immunity: Update on Toll-like receptors
-
Kawai T, Akira S. The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors. Nat Immunol 11: 373-384, 2010.
-
(2010)
Nat Immunol
, vol.11
, pp. 373-384
-
-
Kawai, T.1
Akira, S.2
-
148
-
-
0033971177
-
Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3
-
Kelkar N, Gupta S, Dickens M, Davis RJ. Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3. Mol Cell Biol 20: 1030-1043, 2000.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 1030-1043
-
-
Kelkar, N.1
Gupta, S.2
Dickens, M.3
Davis, R.J.4
-
149
-
-
0042191758
-
Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3)
-
Kelkar N, Delmotte MH, Weston CR, Barrett T, Sheppard BJ, Flavell RA, Davis RJ. Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3). Proc Natl Acad Sci USA 100: 9843-9848, 2003.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 9843-9848
-
-
Kelkar, N.1
Delmotte, M.H.2
Weston, C.R.3
Barrett, T.4
Sheppard, B.J.5
Flavell, R.A.6
Davis, R.J.7
-
150
-
-
15044357454
-
Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways
-
Kelkar N, Standen CL, Davis RJ. Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways. Mol Cell Biol 25: 2733-2743, 2005.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 2733-2743
-
-
Kelkar, N.1
Standen, C.L.2
Davis, R.J.3
-
151
-
-
51349158231
-
Signalling adaptors used by Tol-like receptors: An update
-
Kenny EF, O'Neill LA. Signalling adaptors used by Tol-like receptors: an update. Cytokine 43: 343-350, 2008.
-
(2008)
Cytokine
, vol.43
, pp. 343-350
-
-
Kenny, E.F.1
O'Neill, L.A.2
-
152
-
-
79952112019
-
The MAP kinase signaling cascades: A system of hundreds of components regulates a diverse array of physiological functions
-
Keshet Y, Seger R. The MAP kinase signaling cascades: a system of hundreds of components regulates a diverse array of physiological functions. Methods Mol Biol 661: 3-38, 2010.
-
(2010)
Methods Mol Biol
, vol.661
, pp. 3-38
-
-
Keshet, Y.1
Seger, R.2
-
153
-
-
0029098225
-
Activation of the c-Abl tyrosine kinase in the stress response to DNA damaging agents
-
Kharbanda S, Re R, Pandey P, Shafman TD, Feller S, Weichselbaum RR, Kufe DW. Activation of the c-Abl tyrosine kinase in the stress response to DNA damaging agents. Nature 376: 785-788, 1995.
-
(1995)
Nature
, vol.376
, pp. 785-788
-
-
Kharbanda, S.1
Re, R.2
Pandey, P.3
Shafman, T.D.4
Feller, S.5
Weichselbaum, R.R.6
Kufe, D.W.7
-
154
-
-
0030481580
-
HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway
-
Kiefer F, Tibbles LA, Anafi M, Janssen A, Zanke BW, Lassam N, Pawson T, Woodgett JR, Iscove NR. HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway. EMBO J 15: 7013-7025, 1996.
-
(1996)
EMBO J
, vol.15
, pp. 7013-7025
-
-
Kiefer, F.1
Tibbles, L.A.2
Anafi, M.3
Janssen, A.4
Zanke, B.W.5
Lassam, N.6
Pawson, T.7
Woodgett, J.R.8
Iscove, N.R.9
-
155
-
-
33845979829
-
MEKK3 is essential for lipopolysaccharide-induced interleukin-6 and granulocyte-macrophage colony-stimulating factor production in macrophages
-
Kim K, Duramad O, Qin XF, Su B. MEKK3 is essential for lipopolysaccharide-induced interleukin-6 and granulocyte-macrophage colony-stimulating factor production in macrophages. Immunology 120: 242-250, 2007.
-
(2007)
Immunology
, vol.120
, pp. 242-250
-
-
Kim, K.1
Duramad, O.2
Qin, X.F.3
Su, B.4
-
156
-
-
78650472774
-
Toll-like receptor: Linking inflammation to metabolism
-
Könner AC, Brüning JC. Toll-like receptor: linking inflammation to metabolism. Trends Endocrinol 22: 16-23, 2011.
-
(2011)
Trends Endocrinol
, vol.22
, pp. 16-23
-
-
Könner, A.C.1
Brüning, J.C.2
-
157
-
-
0037121941
-
Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease
-
Kontoyannis D, Boulougouris G, Manoloukos M, Armaka M, Apostolaki M, Pizzaro T, Kotlyarov A, Foster I, Flavell R, Gaestel M, Tsichlis P, Cominelli F, Kollias G. Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel disease. J Exp Med 196: 1563-1573, 2002.
-
(2002)
J Exp Med
, vol.196
, pp. 1563-1573
-
-
Kontoyannis, D.1
Boulougouris, G.2
Manoloukos, M.3
Armaka, M.4
Apostolaki, M.5
Pizzaro, T.6
Kotlyarov, A.7
Foster, I.8
Flavell, R.9
Gaestel, M.10
Tsichlis, P.11
Cominelli, F.12
Kollias, G.13
-
158
-
-
0033567388
-
ECSIT is an evolutionarily conserved intermediate in the Tol/IL-1 signal transduction pathway
-
Kopp E, Medzhitov R, Carothers J, Xiao C, Douglas I, Janeway C, Ghosh S. ECSIT is an evolutionarily conserved intermediate in the Tol/IL-1 signal transduction pathway. Genes Dev 13: 2059-2071, 1999.
-
(1999)
Genes Dev
, vol.13
, pp. 2059-2071
-
-
Kopp, E.1
Medzhitov, R.2
Carothers, J.3
Xiao, C.4
Douglas, I.5
Janeway, C.6
Ghosh, S.7
-
159
-
-
0033145354
-
MAPKAP kinase 2 is essential for LPS-induced TNF-α biosynthesis
-
Kotlyarov A, Neininger C, Schubert R, Eckert C, Birchmeier HD, Volk M, Gaestel M. MAPKAP kinase 2 is essential for LPS-induced TNF-α biosynthesis. Nat Cell Biol 1: 94-97, 1999.
-
(1999)
Nat Cell Biol
, vol.1
, pp. 94-97
-
-
Kotlyarov, A.1
Neininger, C.2
Schubert, R.3
Eckert, C.4
Birchmeier, H.D.5
Volk, M.6
Gaestel, M.7
-
160
-
-
78649338141
-
Autophagy and the integrated stress response
-
Kroemer G, Mariño G, Levine B. Autophagy and the integrated stress response. Mol Cell 40: 280-293, 2010.
-
(2010)
Mol Cell
, vol.40
, pp. 280-293
-
-
Kroemer, G.1
Mariño, G.2
Levine, B.3
-
161
-
-
0033118607
-
The JNK1 and JNK2 protein kinases are required for regional specific apoptosis during early brain development
-
Kuan CY, Yang D, Samata Roy DR, Davis RJ, Rakic P, Flavell RA. The JNK1 and JNK2 protein kinases are required for regional specific apoptosis during early brain development. Neuron 22: 667-676, 1999.
-
(1999)
Neuron
, vol.22
, pp. 667-676
-
-
Kuan, C.Y.1
Yang, D.2
Samata Roy, D.R.3
Davis, R.J.4
Rakic, P.5
Flavell, R.A.6
-
162
-
-
71449095149
-
Two sided ubiquitin binding explains specificity of the TAB2 NZF domain
-
Kulathu Y, Akutsu M, Bremm A, Hofmann K, Komander D. Two sided ubiquitin binding explains specificity of the TAB2 NZF domain. Nat Struct Mol Biol 16: 1328-1330, 2009.
-
(2009)
Nat Struct Mol Biol
, vol.16
, pp. 1328-1330
-
-
Kulathu, Y.1
Akutsu, M.2
Bremm, A.3
Hofmann, K.4
Komander, D.5
-
163
-
-
0024997935
-
pp54 MAP2 kinase, a novel serine/threonine protein kinase regulated by phosphorylation and stimulated by poly-L-lysine
-
Kyriakis JM, Avruch J. pp54 MAP2 kinase, a novel serine/threonine protein kinase regulated by phosphorylation and stimulated by poly-L-lysine. J Biol Chem 265: 17355-17363, 1990.
-
(1990)
J Biol Chem
, vol.265
, pp. 17355-17363
-
-
Kyriakis, J.M.1
Avruch, J.2
-
164
-
-
0025883213
-
pp54 microtubule-associated protein-2 kinase requires both tyrosine and serine/threonine phosphorylation for activity
-
Kyriakis JM, Brautigan DL, Ingebritsen TS, Avruch J. pp54 microtubule-associated protein-2 kinase requires both tyrosine and serine/threonine phosphorylation for activity. J Biol Chem 266: 10043-10046, 1991.
-
(1991)
J Biol Chem
, vol.266
, pp. 10043-10046
-
-
Kyriakis, J.M.1
Brautigan, D.L.2
Ingebritsen, T.S.3
Avruch, J.4
-
165
-
-
0028229012
-
The stress-activated protein kinase subfamily of c-Jun kinases
-
Kyriakis JM, Banerjee P, Nikolakaki E, Dai T, Rubie EA, Ahmad MF, Avruch J, Woodgett JR. The stress-activated protein kinase subfamily of c-Jun kinases. Nature 369: 156-160, 1994.
-
(1994)
Nature
, vol.369
, pp. 156-160
-
-
Kyriakis, J.M.1
Banerjee, P.2
Nikolakaki, E.3
Dai, T.4
Rubie, E.A.5
Ahmad, M.F.6
Avruch, J.7
Woodgett, J.R.8
-
166
-
-
0035066383
-
Mammalian mitogen-activated protein kinase pathways activated by stress and inflammation
-
Kyriakis JM, Avruch J. Mammalian mitogen-activated protein kinase pathways activated by stress and inflammation. Physiol Rev 81: 807-869, 2001.
-
(2001)
Physiol Rev
, vol.81
, pp. 807-869
-
-
Kyriakis, J.M.1
Avruch, J.2
-
167
-
-
0030298138
-
1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade
-
1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade. Cell 87: 519-529, 1996.
-
(1996)
Cell
, vol.87
, pp. 519-529
-
-
Lamarche, N.1
Tapon, N.2
Stowers, L.3
Burbelo, P.4
Aspenstrom, P.5
Bridges, T.6
Chant, J.7
Hall, A.8
-
168
-
-
0033515597
-
HSP27 multimerization mediated by phosphorylation-sensitive intermolecular interactions at the amino terminus
-
Lambert H, Charette SJ, Bernier AF, Guimond A, Landry J. HSP27 multimerization mediated by phosphorylation-sensitive intermolecular interactions at the amino terminus. J Biol Chem 274: 9378-9385, 1999.
-
(1999)
J Biol Chem
, vol.274
, pp. 9378-9385
-
-
Lambert, H.1
Charette, S.J.2
Bernier, A.F.3
Guimond, A.4
Landry, J.5
-
169
-
-
0027215820
-
A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf
-
Lange-Carter CA, Pleiman CM, Gardner AM, Blumer KJ, Johnson GL. A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf. Science 260: 315-319, 1993.
-
(1993)
Science
, vol.260
, pp. 315-319
-
-
Lange-Carter, C.A.1
Pleiman, C.M.2
Gardner, A.M.3
Blumer, K.J.4
Johnson, G.L.5
-
170
-
-
0029911710
-
ERK6, a mitogen-activated protein kinase is involved in C2C12 myoblast differentiation
-
Lechner C, Zahalka MA, Giot JF, Moller NP, Ullrich A. ERK6, a mitogen-activated protein kinase is involved in C2C12 myoblast differentiation. Proc Natl Acad Sci USA 93: 4355-4359, 1996.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 4355-4359
-
-
Lechner, C.1
Zahalka, M.A.2
Giot, J.F.3
Moller, N.P.4
Ullrich, A.5
-
171
-
-
0028605318
-
A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
-
Lee JC, Laydon JT, McDonnell PC, Gallagher TF, Kumar S, Green D, McNulty D, Blumenthal MJ, Heys JR, Landvatter SW, Strickler JE, McLaughlin MM, Siemens IR, Fisher SM, Livi GP, White JR, Adams JL, Young P. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 273: 739-746, 1994.
-
(1994)
Nature
, vol.273
, pp. 739-746
-
-
Lee, J.C.1
Laydon, J.T.2
McDonnell, P.C.3
Gallagher, T.F.4
Kumar, S.5
Green, D.6
McNulty, D.7
Blumenthal, M.J.8
Heys, J.R.9
Landvatter, S.W.10
Strickler, J.E.11
McLaughlin, M.M.12
Siemens, I.R.13
Fisher, S.M.14
Livi, G.P.15
White, J.R.16
Adams, J.L.17
Young, P.18
-
172
-
-
0037418238
-
JNK phosphorylation of Bim-related members of the Bcl2 family induceds Bax-dependent apoptosis
-
Lei K, Davis RJ. JNK phosphorylation of Bim-related members of the Bcl2 family induceds Bax-dependent apoptosis. Proc Natl Acad Sci USA 100: 2432-2437, 2003.
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 2432-2437
-
-
Lei, K.1
Davis, R.J.2
-
173
-
-
0034614656
-
Physical and functional interaction of filamin (actin-binding protein-280) and tumor necrosis factor receptor-associated factor 2
-
Leonardi A, Ellinger-Ziegelbauer H, Franzoso G, Brown K, Siebenlist U. Physical and functional interaction of filamin (actin-binding protein-280) and tumor necrosis factor receptor-associated factor 2. J Biol Chem 275: 271-278, 2000.
-
(2000)
J Biol Chem
, vol.275
, pp. 271-278
-
-
Leonardi, A.1
Ellinger-Ziegelbauer, H.2
Franzoso, G.3
Brown, K.4
Siebenlist, U.5
-
174
-
-
78751672975
-
Autophagy in immunity and inflammation
-
Levine B, Mizushima N, Virgin HW. Autophagy in immunity and inflammation. Nature 469: 323-335, 2011.
-
(2011)
Nature
, vol.469
, pp. 323-335
-
-
Levine, B.1
Mizushima, N.2
Virgin, H.W.3
-
175
-
-
0032484215
-
Dimerization via tandem leucine zippers is essential for the activation of the mitogen-activated protein kinase kinase kinase, MLK-3
-
Leung IWL, Lassam N. Dimerization via tandem leucine zippers is essential for the activation of the mitogen-activated protein kinase kinase kinase, MLK-3. J Biol Chem 273: 32408-32415, 1998.
-
(1998)
J Biol Chem
, vol.273
, pp. 32408-32415
-
-
Leung, I.W.L.1
Lassam, N.2
-
176
-
-
0032930551
-
Interaction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase
-
Ling P, Yao Z, Meyer CF, Wang XS, Oehrl W, Feller SM, Tan TH. Interaction of hematopoietic progenitor kinase 1 with adapter proteins Crk and CrkL leads to synergistic activation of c-Jun N-terminal kinase. Mol Cell Biol 19: 1359-1368, 1999.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 1359-1368
-
-
Ling, P.1
Yao, Z.2
Meyer, C.F.3
Wang, X.S.4
Oehrl, W.5
Feller, S.M.6
Tan, T.H.7
-
177
-
-
0033711185
-
HPK1 is activated by lymphocyte antigen receptors and negatively regulates AP-1
-
Liou J, Kiefer F, Dant A, Hashimoto A, Cobb MH, Kurosaki T, Weiss A. HPK1 is activated by lymphocyte antigen receptors and negatively regulates AP-1. Immunity 12: 399-408, 2000.
-
(2000)
Immunity
, vol.12
, pp. 399-408
-
-
Liou, J.1
Kiefer, F.2
Dant, A.3
Hashimoto, A.4
Cobb, M.H.5
Kurosaki, T.6
Weiss, A.7
-
178
-
-
0033611551
-
A Drosophila TNF-receptor-associated factor bindds the Ste20 kinase Misshapen and activates Jun kinase
-
Liu H, Su YC, Becker E, Treisman J, Skolnik EY. A Drosophila TNF-receptor-associated factor bindds the Ste20 kinase Misshapen and activates Jun kinase. Curr Biol 9: 101-104, 1999.
-
(1999)
Curr Biol
, vol.9
, pp. 101-104
-
-
Liu, H.1
Su, Y.C.2
Becker, E.3
Treisman, J.4
Skolnik, E.Y.5
-
179
-
-
0034001070
-
Activation of apoptosis signal-regulating kinase-1 (ASK1) by TNF receptor-associated factor-2 requires prior dissociation of the ASK1 inhibitor thioredoxin
-
Liu H, Nishitoh H, Ichijo H, Kyriakis JM. Activation of apoptosis signal-regulating kinase-1 (ASK1) by TNF receptor-associated factor-2 requires prior dissociation of the ASK1 inhibitor thioredoxin. Mol Cell Biol 20: 2198-2208, 2000.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 2198-2208
-
-
Liu, H.1
Nishitoh, H.2
Ichijo, H.3
Kyriakis, J.M.4
-
180
-
-
0029856557
-
Three distinct signalling responses by murine fibroblasts to genotoxic stress
-
Liu ZG, Baskaran R, Lea-Chou ET, Wood LD, Chen Y, Karin M, Wang JYJ. Three distinct signalling responses by murine fibroblasts to genotoxic stress. Nature 384: 273-276, 1996.
-
(1996)
Nature
, vol.384
, pp. 273-276
-
-
Liu, Z.G.1
Baskaran, R.2
Lea-Chou, E.T.3
Wood, L.D.4
Chen, Y.5
Karin, M.6
Wang, J.Y.J.7
-
181
-
-
0033118982
-
Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase3 (mkk3)-deficient mice
-
Lu HT, Yang DD, Wysk M, Gatti E, Mellman I, Davis RJ, Flavell RA. Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase3 (mkk3)-deficient mice. EMBO J 18: 1845-1857, 1999.
-
(1999)
EMBO J
, vol.18
, pp. 1845-1857
-
-
Lu, H.T.1
Yang, D.D.2
Wysk, M.3
Gatti, E.4
Mellman, I.5
Davis, R.J.6
Flavell, R.A.7
-
182
-
-
0030770419
-
2-terminal protein kinase (JNK)- activating kinase 2 as an activator of JNK but not p38
-
2-terminal protein kinase (JNK)- activating kinase 2 as an activator of JNK but not p38. J Biol Chem 272: 24751-24754, 1997.
-
(1997)
J Biol Chem
, vol.272
, pp. 24751-24754
-
-
Lu, X.1
Nemoto, S.2
Lin, A.3
-
183
-
-
0036279167
-
The PHD domain of MEKK1acts as an E.3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2
-
Lu Z, Xu S, Joazerio C, Cobb MH, Hunter T. The PHD domain of MEKK1acts as an E.3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2. Mol Cell 9: 945-956, 2002.
-
(2002)
Mol Cell
, vol.9
, pp. 945-956
-
-
Lu, Z.1
Xu, S.2
Joazerio, C.3
Cobb, M.H.4
Hunter, T.5
-
184
-
-
0035971436
-
Partners in transcription: NFAT and AP-1
-
Macián F, López-Rodríguez C, Rao A. Partners in transcription: NFAT and AP-1. Oncogene 20: 2476-2489, 2001.
-
(2001)
Oncogene
, vol.20
, pp. 2476-2489
-
-
Macián, F.1
López-Rodríguez, C.2
Rao, A.3
-
185
-
-
0034816062
-
Mitogen-activated protein kinase p38 controls the expression and posttranslational modification of tristetraprolin, a regulator of tumor necrosis factor alpha mRNA stability
-
Mahtani KR, Brook M, Dean JL, Sully G, Saklatvala J, Clark AR. Mitogen-activated protein kinase p38 controls the expression and posttranslational modification of tristetraprolin, a regulator of tumor necrosis factor alpha mRNA stability. Mol Cell Biol 21: 6461-6469, 2001.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 6461-6469
-
-
Mahtani, K.R.1
Brook, M.2
Dean, J.L.3
Sully, G.4
Saklatvala, J.5
Clark, A.R.6
-
186
-
-
0031017618
-
MAP3K-related kinase involved in NF-κB induction by TNF, CD-95 and IL-1
-
Malinin NL, Boldin MP, Kovalenko AV, Wallach D. MAP3K-related kinase involved in NF-κB induction by TNF, CD-95 and IL-1. Nature 385: 540-544. 1997.
-
(1997)
Nature
, vol.385
, pp. 540-544
-
-
Malinin, N.L.1
Boldin, M.P.2
Kovalenko, A.V.3
Wallach, D.4
-
187
-
-
0027297647
-
The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain
-
Marais R, Wynne J, Treisman R. The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain. Cell 73: 381-393, 1993.
-
(1993)
Cell
, vol.73
, pp. 381-393
-
-
Marais, R.1
Wynne, J.2
Treisman, R.3
-
188
-
-
0030614745
-
Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK1 and is required for tumor necrosis factor-α activation of SAPK in mammalian cells
-
Marti A, Luo Z, Cunningham C, Ohta Y, Hartwig J, Stossel T, Kyriakis JM, Avruch J. Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK1 and is required for tumor necrosis factor-α activation of SAPK in mammalian cells. J Biol Chem 272: 2620-2628, 1997.
-
(1997)
J Biol Chem
, vol.272
, pp. 2620-2628
-
-
Marti, A.1
Luo, Z.2
Cunningham, C.3
Ohta, Y.4
Hartwig, J.5
Stossel, T.6
Kyriakis, J.M.7
Avruch, J.8
-
190
-
-
48749090228
-
Essential cytoplasmic translocation of a cytokine receptorassembled signaling complex
-
Matsuzawa A, Tseng PH, Vallabhapurapu S, Luo JL, Zhang W, Wang H, Vignali DAA, Gallagher E, Karin M. Essential cytoplasmic translocation of a cytokine receptorassembled signaling complex. Science 321: 663-668, 2008.
-
(2008)
Science
, vol.321
, pp. 663-668
-
-
Matsuzawa, A.1
Tseng, P.H.2
Vallabhapurapu, S.3
Luo, J.L.4
Zhang, W.5
Wang, H.6
Vignali, D.A.A.7
Gallagher, E.8
Karin, M.9
-
191
-
-
0035430282
-
Transcriptional regulation by the phosphorylation-dependent factor CREB
-
Mayr B, Montminy M. Transcriptional regulation by the phosphorylation-dependent factor CREB. Nat Rev Mol Cell Biol 2: 599-609.
-
Nat Rev Mol Cell Biol
, vol.2
, pp. 599-609
-
-
Mayr, B.1
Montminy, M.2
-
192
-
-
34248575149
-
Integrating signals from RTKs to ERK/MAPK
-
McKay MM, Morrison DK. Integrating signals from RTKs to ERK/MAPK. Oncogene 26: 3113-3121, 2007.
-
(2007)
Oncogene
, vol.26
, pp. 3113-3121
-
-
McKay, M.M.1
Morrison, D.K.2
-
193
-
-
0029923193
-
Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase
-
McLaughlin MM, Kumar S, McDonnell PC, Van Horn S, Lee JC, Livi GP, Young PR. Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase. J Biol Chem 271: 8488-8492, 1996.
-
(1996)
J Biol Chem
, vol.271
, pp. 8488-8492
-
-
McLaughlin, M.M.1
Kumar, S.2
McDonnell, P.C.3
van Horn, S.4
Lee, J.C.5
Livi, G.P.6
Young, P.R.7
-
194
-
-
0029913458
-
SAP kinase-3, a new member of the family of mammalian stress-activated protein kinases
-
Merten S, Craxton M, Goedert M. SAP kinase-3, a new member of the family of mammalian stress-activated protein kinases. FEBS Lett 383: 273-276, 1996.
-
(1996)
FEBS Lett
, vol.383
, pp. 273-276
-
-
Merten, S.1
Craxton, M.2
Goedert, M.3
-
195
-
-
33746028777
-
Intracellular pattern recognition receptors in the host response
-
Meylan E, Tschopp J, Karin M. Intracellular pattern recognition receptors in the host response. Nature 442: 39-44, 2006.
-
(2006)
Nature
, vol.442
, pp. 39-44
-
-
Meylan, E.1
Tschopp, J.2
Karin, M.3
-
196
-
-
0033592944
-
MEKK1 suppresses oxidative stress-induced apoptosis of embryonic stem cell-derived cardiac myocytes
-
Minamino T, Yujiri T, Papst PJ, Chan ED, Johnson GL, Terada N. MEKK1 suppresses oxidative stress-induced apoptosis of embryonic stem cell-derived cardiac myocytes. Proc Natl Acad Sci USA 96: 15127-15132, 1999.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 15127-15132
-
-
Minamino, T.1
Yujiri, T.2
Papst, P.J.3
Chan, E.D.4
Johnson, G.L.5
Terada, N.6
-
197
-
-
0028568217
-
Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK
-
Minden A, Lin A, McMahon M, Lange-Carter C, Dérijard B, Davis RJ, Johnson GL, Karin M. Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK. Science 266: 1719-1723, 1994.
-
(1994)
Science
, vol.266
, pp. 1719-1723
-
-
Minden, A.1
Lin, A.2
McMahon, M.3
Lange-Carter, C.4
Dérijard, B.5
Davis, R.J.6
Johnson, G.L.7
Karin, M.8
-
198
-
-
0029070887
-
Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs
-
Minden A, Lin A, Claret FX, Abo A, Karin M. Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell 81: 1147-1157, 1995.
-
(1995)
Cell
, vol.81
, pp. 1147-1157
-
-
Minden, A.1
Lin, A.2
Claret, F.X.3
Abo, A.4
Karin, M.5
-
199
-
-
0034635507
-
PSK, a novel STE20-like kinase derived from prostatic carcinoma that activates the c-Jun N-terminal kinase mitogen-activated protein kinase pathway and regulates actin cytoskeletal organization
-
Moore TM, Garg R, Johnson C, Coptcoat MJ, Ridley AJ, Morris JDH. PSK, a novel STE20-like kinase derived from prostatic carcinoma that activates the c-Jun N-terminal kinase mitogen-activated protein kinase pathway and regulates actin cytoskeletal organization. J Biol Chem 275: 4311-4322, 2000.
-
(2000)
J Biol Chem
, vol.275
, pp. 4311-4322
-
-
Moore, T.M.1
Garg, R.2
Johnson, C.3
Coptcoat, M.J.4
Ridley, A.J.5
Morris, J.D.H.6
-
200
-
-
15844431960
-
A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3
-
Moriguchi T, Kuroyanagi N, Yamaguchi K, Gotoh Y, Irie K, Kano T, Shirakabe K, Muro Y, Shibuya H, Matsumoto K, Nishida E, Hagiwara M. A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3. J Biol Chem 271: 13675-13679, 1996.
-
(1996)
J Biol Chem
, vol.271
, pp. 13675-13679
-
-
Moriguchi, T.1
Kuroyanagi, N.2
Yamaguchi, K.3
Gotoh, Y.4
Irie, K.5
Kano, T.6
Shirakabe, K.7
Muro, Y.8
Shibuya, H.9
Matsumoto, K.10
Nishida, E.11
Hagiwara, M.12
-
201
-
-
58149347680
-
Muscle-specific IRS-1 Ser → Ala transgenic mice are protected from fat-induced insulin resistance in skeletal muscle
-
Morino K, Neschen S, Bilz S, Sono S, Tsirigotis D, Reznick RM, Moore I, Nagai Y, Samuel V, Sebastian D, White M, Philbrick W, Shulman GI. Muscle-specific IRS-1 Ser → Ala transgenic mice are protected from fat-induced insulin resistance in skeletal muscle. Diabetes 57: 2644-2651, 2008.
-
(2008)
Diabetes
, vol.57
, pp. 2644-2651
-
-
Morino, K.1
Neschen, S.2
Bilz, S.3
Sono, S.4
Tsirigotis, D.5
Reznick, R.M.6
Moore, I.7
Nagai, Y.8
Samuel, V.9
Sebastian, D.10
White, M.11
Philbrick, W.12
Shulman, G.I.13
-
202
-
-
0029585369
-
Ischemia and reperfusion enhance ATF-2 and c-Jun binding to cAMP response elements and to an AP-1 binding site from the c-Jun promoter
-
Morooka H, Bonventre JV, Pombo CM, Kyriakis JM, Force T. Ischemia and reperfusion enhance ATF-2 and c-Jun binding to cAMP response elements and to an AP-1 binding site from the c-Jun promoter. J Biol Chem 270: 30084-30092, 1995.
-
(1995)
J Biol Chem
, vol.270
, pp. 30084-30092
-
-
Morooka, H.1
Bonventre, J.V.2
Pombo, C.M.3
Kyriakis, J.M.4
Force, T.5
-
203
-
-
0344393408
-
Regulation of MAP kinase signaling modules by scaffold proteins in mammals
-
Morrison DK, Davis RJ. Regulation of MAP kinase signaling modules by scaffold proteins in mammals. Annu Rev Cell Dev Biol 19: 91-118, 2003.
-
(2003)
Annu Rev Cell Dev Biol
, vol.19
, pp. 91-118
-
-
Morrison, D.K.1
Davis, R.J.2
-
204
-
-
0031023756
-
Reduced ubiquitin-dependent degradation of c-Jun after phosphorylation by MAP kinases
-
Musti AM, Treier M, Bohmann D. Reduced ubiquitin-dependent degradation of c-Jun after phosphorylation by MAP kinases. Science 275: 400-402, 1997.
-
(1997)
Science
, vol.275
, pp. 400-402
-
-
Musti, A.M.1
Treier, M.2
Bohmann, D.3
-
205
-
-
0032526694
-
PRAK, a novel protein kinase regulated by the p38 MAP kinase
-
New L, Jiang Y, Zhao M, Liu K, Zhu W, Flood LJ, Kato Y, Parry GCN, Han J. PRAK, a novel protein kinase regulated by the p38 MAP kinase. EMBO J 17: 3372-3384, 1998.
-
(1998)
EMBO J
, vol.17
, pp. 3372-3384
-
-
New, L.1
Jiang, Y.2
Zhao, M.3
Liu, K.4
Zhu, W.5
Flood, L.J.6
Kato, Y.7
Parry, G.C.N.8
Han, J.9
-
206
-
-
34250795555
-
c-Jun N-terminal kinase signaling regulates events associated with both health and degeneration in motoneurons
-
Newbern J, Taylor A, Robinson M, Lively MO, Milligan CE. c-Jun N-terminal kinase signaling regulates events associated with both health and degeneration in motoneurons. Neuroscience 147: 680-692, 2007.
-
(2007)
Neuroscience
, vol.147
, pp. 680-692
-
-
Newbern, J.1
Taylor, A.2
Robinson, M.3
Lively, M.O.4
Milligan, C.E.5
-
207
-
-
0033580466
-
The kinase TAK1 can activate the NIK-IκB as well as the MAP kinase cascade in the IL-1 signalling pathway
-
Ninomiya-Tsuji J, Kishioto K, Hiyama A, Inoue JI, Cao Z, andMatsumoto K. The kinase TAK1 can activate the NIK-IκB as well as the MAP kinase cascade in the IL-1 signalling pathway. Nature 398: 252-256, 1999.
-
(1999)
Nature
, vol.398
, pp. 252-256
-
-
Ninomiya-Tsuji, J.1
Kishioto, K.2
Hiyama, A.3
Inoue, J.I.4
Cao, Z.5
Andmatsumoto, K.6
-
208
-
-
0031029214
-
Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3
-
Nishina H, Fischer KD, Radvanyi L, Shahinian A, Razqallah H, Rubie EA, Bernstein A, Mak TW, Woodgett JR, Penninger JM. Stress-signalling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3. Nature 385: 350-353, 1997.
-
(1997)
Nature
, vol.385
, pp. 350-353
-
-
Nishina, H.1
Fischer, K.D.2
Radvanyi, L.3
Shahinian, A.4
Razqallah, H.5
Rubie, E.A.6
Bernstein, A.7
Mak, T.W.8
Woodgett, J.R.9
Penninger, J.M.10
-
209
-
-
0033063568
-
Defective liver formation and liver cell apoptosis in mice lacking the stress signaling kinase SEK1/MKK4
-
Nishina H, Vaz A, Billia P, Nghiem M, Sasaki T, de la Pompa JL, Furlonger K, Paige C, Hui C, Fischer KD, Kishimoto H, Iwatsubo T, Katada T, Woodgett JR, Penninger JM. Defective liver formation and liver cell apoptosis in mice lacking the stress signaling kinase SEK1/MKK4. Development 126: 505-516, 1999.
-
(1999)
Development
, vol.126
, pp. 505-516
-
-
Nishina, H.1
Vaz, A.2
Billia, P.3
Nghiem, M.4
Sasaki, T.5
de la Pompa, J.L.6
Furlonger, K.7
Paige, C.8
Hui, C.9
Fischer, K.D.10
Kishimoto, H.11
Iwatsubo, T.12
Katada, T.13
Woodgett, J.R.14
Penninger, J.M.15
-
210
-
-
33744974570
-
MEX is a testis-specific E3 ubiquitin ligase that promotes death receptor-induced apoptosis
-
Nishito Y, Hasegawa M, Inohara N, Núñez G. MEX is a testis-specific E3 ubiquitin ligase that promotes death receptor-induced apoptosis. Biochem J 396: 411-417, 2006.
-
(2006)
Biochem J
, vol.396
, pp. 411-417
-
-
Nishito, Y.1
Hasegawa, M.2
Inohara, N.3
Núñez, G.4
-
211
-
-
0032158987
-
ASK1 is essential for JNK/SAPK activation by TRAF2
-
Nishitoh H, Saitoh M, Mochida Y, Takeda K, Nakano H, Rothe M, Miyazono K, Ichijo H. ASK1 is essential for JNK/SAPK activation by TRAF2. Mol Cell 2: 389-395, 1998.
-
(1998)
Mol Cell
, vol.2
, pp. 389-395
-
-
Nishitoh, H.1
Saitoh, M.2
Mochida, Y.3
Takeda, K.4
Nakano, H.5
Rothe, M.6
Miyazono, K.7
Ichijo, H.8
-
212
-
-
33748689930
-
Activated c-Jun N-terminal kinase is requried for axon formation
-
Oliva AA Jr, Atkins CM, Copenagle L, Banker GA. Activated c-Jun N-terminal kinase is requried for axon formation. J Neurosci 26: 9462-9470, 2006.
-
(2006)
J Neurosci
, vol.26
, pp. 9462-9470
-
-
Oliva Jr., A.A.1
Atkins, C.M.2
Copenagle, L.3
Banker, G.A.4
-
213
-
-
0037226672
-
Mal and MyD88: Adapter proteins involved in signal transduction by Toll-like receptors
-
O'Neill LA, Dunne A, Edjeback M, Gray P, Jefferies C, Wietek C. Mal and MyD88: adapter proteins involved in signal transduction by Toll-like receptors. J Endotoxin Res 9: 55-59, 2003.
-
(2003)
J Endotoxin Res
, vol.9
, pp. 55-59
-
-
O'Neill, L.A.1
Dunne, A.2
Edjeback, M.3
Gray, P.4
Jefferies, C.5
Wietek, C.6
-
214
-
-
1842843855
-
Roles of CHOP/GADD153 in endoplasmic reticulum stress
-
Oyadomari S, Mori M. Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ 11: 389-391, 2004.
-
(2004)
Cell Death Differ
, vol.11
, pp. 389-391
-
-
Oyadomari, S.1
Mori, M.2
-
215
-
-
5644231992
-
Endoplasmic reticulum stress links obesity, insulin action and type 2 diabetes
-
Ozcan U, Cao Q, Yilmaz E, Lee AH, Iwakoshi NN, Özdelen E, Tuncman G, Görgün C, Glimcher LH, Hotamisligil G. Endoplasmic reticulum stress links obesity, insulin action and type 2 diabetes. Science 306: 457-461, 2004.
-
(2004)
Science
, vol.306
, pp. 457-461
-
-
Ozcan, U.1
Cao, Q.2
Yilmaz, E.3
Lee, A.H.4
Iwakoshi, N.N.5
Özdelen, E.6
Tuncman, G.7
Görgün, C.8
Glimcher, L.H.9
Hotamisligil, G.10
-
216
-
-
0029796368
-
Activation of p38 mitogen-activated protein kinase by c-Abl-dependent and -independent mechanisms
-
Pandey P, Raingeaud J, Kaneki M, Weichselbaum R, Davis RJ, Kufe D, Kharbanda S. Activation of p38 mitogen-activated protein kinase by c-Abl-dependent and -independent mechanisms. J Biol Chem 271: 23755-23779, 1996.
-
(1996)
J Biol Chem
, vol.271
, pp. 23755-23779
-
-
Pandey, P.1
Raingeaud, J.2
Kaneki, M.3
Weichselbaum, R.4
Davis, R.J.5
Kufe, D.6
Kharbanda, S.7
-
217
-
-
0037043688
-
Wnt-11 activation of a non-canonical Wnt signalling pathway is required for cardiogenesis
-
Pandur P, Lasche M, Eisenberg LM, Kuhl M. Wnt-11 activation of a non-canonical Wnt signalling pathway is required for cardiogenesis. Nature 418: 636-641, 2002.
-
(2002)
Nature
, vol.418
, pp. 636-641
-
-
Pandur, P.1
Lasche, M.2
Eisenberg, L.M.3
Kuhl, M.4
-
218
-
-
33744455163
-
ABIN-2 is required for optimal activation of Erk MAP kinase in innate immune responses
-
Papoutsopoulou S, Symons A, Tharmalingham T, Belich MP, Kaiser F, Kioussis D, O'Garra A, Tybulewicz V, Ley SC. ABIN-2 is required for optimal activation of Erk MAP kinase in innate immune responses. Nat Immunol 7: 606-615, 2006.
-
(2006)
Nat Immunol
, vol.7
, pp. 606-615
-
-
Papoutsopoulou, S.1
Symons, A.2
Tharmalingham, T.3
Belich, M.P.4
Kaiser, F.5
Kioussis, D.6
O'Garra, A.7
Tybulewicz, V.8
Ley, S.C.9
-
219
-
-
0027447467
-
Tumor progression locus 2 (Tpl-2) encodes a protein kinase involved in the progression of rodent T-cell lymphomas and in T-cell activation
-
Patriotis C, Makris A, Bear SE, Tsichlis PN. Tumor progression locus 2 (Tpl-2) encodes a protein kinase involved in the progression of rodent T-cell lymphomas and in T-cell activation. Proc Natl Acad Sci USA 90: 2251-2255, 1993.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 2251-2255
-
-
Patriotis, C.1
Makris, A.2
Bear, S.E.3
Tsichlis, P.N.4
-
220
-
-
0030669392
-
A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation
-
Paz K, Hemi R, LeRoith D, Karasik A, Elhanany E, Kanety H, Zick Y. A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation. J Biol Chem 272: 29911-29918, 1997.
-
(1997)
J Biol Chem
, vol.272
, pp. 29911-29918
-
-
Paz, K.1
Hemi, R.2
Leroith, D.3
Karasik, A.4
Elhanany, E.5
Kanety, H.6
Zick, Y.7
-
221
-
-
79953227706
-
Tumor progression locus 2 (TPL2) regulates obesity-associated inflammation and insulin resistance
-
Perfield JW, Lee Y, Shulman GI, Samuel VT, Jurczak MH, Ghang E, Xie C, Tsichlis PN, Obin MS, Greenberg AS. Tumor progression locus 2 (TPL2) regulates obesity-associated inflammation and insulin resistance. Diabetes 60: 1168-1176, 2011.
-
(2011)
Diabetes
, vol.60
, pp. 1168-1176
-
-
Perfield, J.W.1
Lee, Y.2
Shulman, G.I.3
Samuel, V.T.4
Jurczak, M.H.5
Ghang, E.6
Xie, C.7
Tsichlis, P.N.8
Obin, M.S.9
Greenberg, A.S.10
-
223
-
-
0027946514
-
The stressactivated protein kinases are major c-Jun amino-terminal kinases activated by ischemia and reperfusion
-
Pombo CM, Bonventre JV, Avruch J, Woodgett JR, Kyriakis JM, Force T. The stressactivated protein kinases are major c-Jun amino-terminal kinases activated by ischemia and reperfusion. J Biol Chem 269: 25546-26551, 1994.
-
(1994)
J Biol Chem
, vol.269
, pp. 25546-26551
-
-
Pombo, C.M.1
Bonventre, J.V.2
Avruch, J.3
Woodgett, J.R.4
Kyriakis, J.M.5
Force, T.6
-
224
-
-
0028845253
-
Activation of the SAPK pathway by the human STE20 homologue germinal center kinase
-
Pombo CM, Kehrl JH, Sánchez I, Katz P, Avruch J, Zon LI, Woodgett JR, Force T, Kyriakis JM. Activation of the SAPK pathway by the human STE20 homologue germinal center kinase. Nature 377: 750-754, 1995.
-
(1995)
Nature
, vol.377
, pp. 750-754
-
-
Pombo, C.M.1
Kehrl, J.H.2
Sánchez, I.3
Katz, P.4
Avruch, J.5
Zon, L.I.6
Woodgett, J.R.7
Force, T.8
Kyriakis, J.M.9
-
225
-
-
0026004501
-
Phosphorylation of c-jun mediated by MAP kinases
-
Pulverer BJ, Kyriakis JM, Avruch J, Nikolakaki E, Woodgett JR. Phosphorylation of c-jun mediated by MAP kinases. Nature 353: 670-674, 1991.
-
(1991)
Nature
, vol.353
, pp. 670-674
-
-
Pulverer, B.J.1
Kyriakis, J.M.2
Avruch, J.3
Nikolakaki, E.4
Woodgett, J.R.5
-
226
-
-
33746365872
-
TLR8-mediated NF-κB and JNK activation are TAK1-independent and MEKK3-dependent
-
Qin J, Yao J, Cui G, Xiao H, Kim TW, Fraczek J, Wightman P, Sato S, Akira S, Puel A, Casanova JL, Su B, Li X. TLR8-mediated NF-κB and JNK activation are TAK1-independent and MEKK3-dependent. J Biol Chem 281: 21013-21021, 2006.
-
(2006)
J Biol Chem
, vol.281
, pp. 21013-21021
-
-
Qin, J.1
Yao, J.2
Cui, G.3
Xiao, H.4
Kim, T.W.5
Fraczek, J.6
Wightman, P.7
Sato, S.8
Akira, S.9
Puel, A.10
Casanova, J.L.11
Su, B.12
Li, X.13
-
227
-
-
0030051528
-
MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway
-
Raingeaud J, Whitmarsh AJ, Barett T, Dérijard B, Davis RJ. MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway. Mol Cell Biol 16: 1247-1255, 1996.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 1247-1255
-
-
Raingeaud, J.1
Whitmarsh, A.J.2
Barett, T.3
Dérijard, B.4
Davis, R.J.5
-
228
-
-
33845654723
-
IL-10-induced TNF-α mRNA destabilization is mediated via IL-10 suppression of p38 MAP kinase activation and inhibition of HuR expression
-
Rajasingh J, Bord E, Luedemann C, Asai J, Hamada H, Thorne T, Qin G, Goukassian D, Zhu Y, Losordo DW, Kishore R. IL-10-induced TNF-α mRNA destabilization is mediated via IL-10 suppression of p38 MAP kinase activation and inhibition of HuR expression. FASEB J 20: 2112-2114, 2006.
-
(2006)
FASEB J
, vol.20
, pp. 2112-2114
-
-
Rajasingh, J.1
Bord, E.2
Luedemann, C.3
Asai, J.4
Hamada, H.5
Thorne, T.6
Qin, G.7
Goukassian, D.8
Zhu, Y.9
Losordo, D.W.10
Kishore, R.11
-
229
-
-
34248597065
-
Differential regulation and properties of MAPKs
-
Raman M, Chen W, Cobb MH. Differential regulation and properties of MAPKs. Oncogene 26: 3100-3112, 2007.
-
(2007)
Oncogene
, vol.26
, pp. 3100-3112
-
-
Raman, M.1
Chen, W.2
Cobb, M.H.3
-
230
-
-
0029760613
-
The mixed lineage protein kinase SPRK phosphorylates and activates the stress-activated protein kinase activator, SEK1
-
Rana A, Gallo K, Godowski P, Hirai Si Ohno S, Zon LI, Kyriakis JM, Avruch J. The mixed lineage protein kinase SPRK phosphorylates and activates the stress-activated protein kinase activator, SEK1. J Biol Chem 271: 19025-19028, 1996.
-
(1996)
J Biol Chem
, vol.271
, pp. 19025-19028
-
-
Rana, A.1
Gallo, K.2
Godowski, P.3
Hirai, S.4
Ohno, S.5
Zon, L.I.6
Kyriakis, J.M.7
Avruch, J.8
-
231
-
-
0033615078
-
Ribosomal S6 kinase 1 (RSK1) activation requires signals dependent on and independent of the MAP kinase ERK
-
Richards SA, Fu J, Romanelli A, Shimamura A, Blenis J. Ribosomal S6 kinase 1 (RSK1) activation requires signals dependent on and independent of the MAP kinase ERK. Curr Biol 9: 810-820, 1999.
-
(1999)
Curr Biol
, vol.9
, pp. 810-820
-
-
Richards, S.A.1
Fu, J.2
Romanelli, A.3
Shimamura, A.4
Blenis, J.5
-
232
-
-
61849123548
-
Regulation of the immune response by stress-activated protein kinases
-
Rincón M, Davis RJ. Regulation of the immune response by stress-activated protein kinases. Immunol Rev 228: 212-224, 2009.
-
(2009)
Immunol Rev
, vol.228
, pp. 212-224
-
-
Rincón, M.1
Davis, R.J.2
-
233
-
-
33845807361
-
The mitogen-activated protein kinase (MAPK)-activated protein kinases MK2 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK
-
Ronkina N, Kotlyarov A, Dittrich-Breiholz O, Kracht M, Hitti E, Milarski K, Askew R, Marusic S, Lin LL, Gaestel M, Telliez JB. The mitogen-activated protein kinase (MAPK)-activated protein kinases MK2 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK. Mol Cell Biol 27: 170-181, 2007.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 170-181
-
-
Ronkina, N.1
Kotlyarov, A.2
Dittrich-Breiholz, O.3
Kracht, M.4
Hitti, E.5
Milarski, K.6
Askew, R.7
Marusic, S.8
Lin, L.L.9
Gaestel, M.10
Telliez, J.B.11
-
234
-
-
78049434471
-
MAPKAP kinases MK2 and MK3 in inflammation: Complex regulation of TNF biosynthesis via expression and phosphorylation of tristetraprolin
-
Ronkina N, Menon MB, Schwermann J, Tiedje C, Hitti E, Kotlyarov A, Gaestel M. MAPKAP kinases MK2 and MK3 in inflammation: complex regulation of TNF biosynthesis via expression and phosphorylation of tristetraprolin. Biochem Pharmacol 80: 1915-1920, 2010.
-
(2010)
Biochem Pharmacol
, vol.80
, pp. 1915-1920
-
-
Ronkina, N.1
Menon, M.B.2
Schwermann, J.3
Tiedje, C.4
Hitti, E.5
Kotlyarov, A.6
Gaestel, M.7
-
235
-
-
78149478401
-
Mitogen-activated protein kinase signaling in the heart: Angels versus demons in a heart-breaking tale
-
Rose BA, Force T, Wang Y. Mitogen-activated protein kinase signaling in the heart: angels versus demons in a heart-breaking tale. Physiol Rev 90: 1507-1546, 2010.
-
(2010)
Physiol Rev
, vol.90
, pp. 1507-1546
-
-
Rose, B.A.1
Force, T.2
Wang, Y.3
-
236
-
-
77956124562
-
Raf protein-serine/threonine kinases: Structure and regulation
-
Roskoski R Jr. Raf protein-serine/threonine kinases: structure and regulation. Biochem Biophys Res Commun 399: 313-317, 2010.
-
(2010)
Biochem Biophys Res Commun
, vol.399
, pp. 313-317
-
-
Roskoski Jr., R.1
-
237
-
-
0028022750
-
A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins
-
Rouse J, Cohen P, Trigon S, Morange M, Alonso-Llamazares A, Zamanillo D, Hunt T, Nebreda A. A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins. Cell 78: 1027-1037, 1994.
-
(1994)
Cell
, vol.78
, pp. 1027-1037
-
-
Rouse, J.1
Cohen, P.2
Trigon, S.3
Morange, M.4
Alonso-Llamazares, A.5
Zamanillo, D.6
Hunt, T.7
Nebreda, A.8
-
238
-
-
0037011121
-
Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs
-
Rousseau S, Morrice N, Peggie M, Campbell DG, Gaestel M, Cohen P. Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs. EMBO J 21: 6505-6514, 2002.
-
(2002)
EMBO J
, vol.21
, pp. 6505-6514
-
-
Rousseau, S.1
Morrice, N.2
Peggie, M.3
Campbell, D.G.4
Gaestel, M.5
Cohen, P.6
-
239
-
-
0033545386
-
JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development
-
Sabapathy K, Hu Y, Kallunki T, Schreiber M, David JP, Jochum W, Wagner EF, Karin M. JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development. Curr Biol 9: 116-125, 1999.
-
(1999)
Curr Biol
, vol.9
, pp. 116-125
-
-
Sabapathy, K.1
Hu, Y.2
Kallunki, T.3
Schreiber, M.4
David, J.P.5
Jochum, W.6
Wagner, E.F.7
Karin, M.8
-
240
-
-
0032724021
-
Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2
-
Sabapathy K, Jochum W, Hochedlinger K, Chang L, Karin M, Wagner EF. Defective neural tube morphogenesis and altered apoptosis in the absence of both JNK1 and JNK2. Mech Dev 89: 115-124, 1999.
-
(1999)
Mech Dev
, vol.89
, pp. 115-124
-
-
Sabapathy, K.1
Jochum, W.2
Hochedlinger, K.3
Chang, L.4
Karin, M.5
Wagner, E.F.6
-
241
-
-
57349101675
-
A stress signaling pathway in adipose tissue regulates hepatic insulin resistance
-
Sabio G, Das M, Mora A, Zhang Z, Jun JY, Ko HJ, Barrett T, Kim JK, Davis RJ. A stress signaling pathway in adipose tissue regulates hepatic insulin resistance. Science 322: 1539-1543, 2008.
-
(2008)
Science
, vol.322
, pp. 1539-1543
-
-
Sabio, G.1
Das, M.2
Mora, A.3
Zhang, Z.4
Jun, J.Y.5
Ko, H.J.6
Barrett, T.7
Kim, J.K.8
Davis, R.J.9
-
242
-
-
70449927269
-
Prevention of steatosis by hepatic JNK1
-
Sabio G, Cavanagh-Kyros J, Ko HJ, Jung DY, Gray S, Jun JY, Barrett T, Mora A, Kim JK, Davis RJ. Prevention of steatosis by hepatic JNK1. Cell Metab 10: 491-498, 2009.
-
(2009)
Cell Metab
, vol.10
, pp. 491-498
-
-
Sabio, G.1
Cavanagh-Kyros, J.2
Ko, H.J.3
Jung, D.Y.4
Gray, S.5
Jun, J.Y.6
Barrett, T.7
Mora, A.8
Kim, J.K.9
Davis, R.J.10
-
243
-
-
73549091444
-
2-terminal kinase 1 in obesity-induced insulin resistance
-
2-terminal kinase 1 in obesity-induced insulin resistance. Mol Cell Biol 30: 106-115, 2010.
-
(2010)
Mol Cell Biol
, vol.30
, pp. 106-115
-
-
Sabio, G.1
Kennedy, N.J.2
Cavanagh-Kyros, J.3
Jung, D.Y.4
Ko, H.J.5
Ong, H.6
Barrett, T.7
Kim, J.K.8
Davis, R.J.9
-
244
-
-
76149090834
-
Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1
-
Sabio G, Cavanagh-Kyros J, Barrett T, Jung DY, Ko HJ, Ong H, Morel C, Mora A, Reilly J, Kim JK, Davis RJ. Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1. Genes Dev 24: 256-264, 2010.
-
(2010)
Genes Dev
, vol.24
, pp. 256-264
-
-
Sabio, G.1
Cavanagh-Kyros, J.2
Barrett, T.3
Jung, D.Y.4
Ko, H.J.5
Ong, H.6
Morel, C.7
Mora, A.8
Reilly, J.9
Kim, J.K.10
Davis, R.J.11
-
245
-
-
0032080283
-
Mammalian thioredoxin is a direct inhibitor of apoptosis signalregulating kinase (ASK) 1
-
Saitoh M, Nishitoh H, Fujii M, Takeda K, Tobiume K, Sawada Y, Kawabata M, Miyazono K, Ichijo H. Mammalian thioredoxin is a direct inhibitor of apoptosis signalregulating kinase (ASK) 1. EMBO J 17: 2596-2606, 1998.
-
(1998)
EMBO J
, vol.17
, pp. 2596-2606
-
-
Saitoh, M.1
Nishitoh, H.2
Fujii, M.3
Takeda, K.4
Tobiume, K.5
Sawada, Y.6
Kawabata, M.7
Miyazono, K.8
Ichijo, H.9
-
246
-
-
3342918498
-
The p38 MAP kinase pathway as a therapeutic target in inflammatory disease
-
Saklatvala J. The p38 MAP kinase pathway as a therapeutic target in inflammatory disease. Curr Opin Pharmocol 4: 372-377, 2004.
-
(2004)
Curr Opin Pharmocol
, vol.4
, pp. 372-377
-
-
Saklatvala, J.1
-
247
-
-
33746032571
-
Loss of hepatic NF-κB activity enhances chemical hepatocarcinogenesis through sustained c-Jun-N-terminal kinase activation
-
Sakurai T, Maeda S, Chang L, Karin M. Loss of hepatic NF-κB activity enhances chemical hepatocarcinogenesis through sustained c-Jun-N-terminal kinase activation. Proc Natl Acad Sci USA 103: 10544-10551, 2006.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 10544-10551
-
-
Sakurai, T.1
Maeda, S.2
Chang, L.3
Karin, M.4
-
248
-
-
48649109203
-
Hepatocyte necrosis induced by oxidative stress and IL-1α release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis
-
Sakurai T, He G, Matsuzawa A, Yu GY, Maeda S, Hardiman G, Karin M. Hepatocyte necrosis induced by oxidative stress and IL-1α release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis. Cancer Cell 14: 156-165, 2008.
-
(2008)
Cancer Cell
, vol.14
, pp. 156-165
-
-
Sakurai, T.1
He, G.2
Matsuzawa, A.3
Yu, G.Y.4
Maeda, S.5
Hardiman, G.6
Karin, M.7
-
249
-
-
0030059508
-
Activation of MEK-1 and SEK-1 by Tpl-2 proto oncoprotein, a novel MAP kinase kinase kinase
-
Salmerón A, Ahmad TB, Carlile GW, Pappin D, Narsimhan RP, Ley SC. Activation of MEK-1 and SEK-1 by Tpl-2 proto oncoprotein, a novel MAP kinase kinase kinase. EMBO J 15: 817-826, 1996.
-
(1996)
EMBO J
, vol.15
, pp. 817-826
-
-
Salmerón, A.1
Ahmad, T.B.2
Carlile, G.W.3
Pappin, D.4
Narsimhan, R.P.5
Ley, S.C.6
-
250
-
-
16844367955
-
Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases
-
Salvador JM, Mittelstadt PR, Guszczynski T, Copeland TD, Yamaguchi H, Appella E, Fornace AJ Jr, Ashwell JD. Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases. Nat Immunol 6: 390-395, 2005.
-
(2005)
Nat Immunol
, vol.6
, pp. 390-395
-
-
Salvador, J.M.1
Mittelstadt, P.R.2
Guszczynski, T.3
Copeland, T.D.4
Yamaguchi, H.5
Appella, E.6
Fornace Jr., A.J.7
Ashwell, J.D.8
-
251
-
-
16844366591
-
The autoimmune suppressor Gadd45α inhibits the T cell alternative p38 activation pathway
-
Salvador JM, Mittelstadt PR, Belova GI, Fornace AJ Jr, Ashwell JD. The autoimmune suppressor Gadd45α inhibits the T cell alternative p38 activation pathway. Nat Immunol 6: 396-402, 2005.
-
(2005)
Nat Immunol
, vol.6
, pp. 396-402
-
-
Salvador, J.M.1
Mittelstadt, P.R.2
Belova, G.I.3
Fornace Jr., A.J.4
Ashwell, J.D.5
-
252
-
-
0028558986
-
Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun
-
Sánchez I, Hughes RT, Mayer BJ, Yee K, Woodgett JR, Avruch J, Kyriakis JM, Zon LI. Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun. Nature 372: 794-798, 1994.
-
(1994)
Nature
, vol.372
, pp. 794-798
-
-
Sánchez, I.1
Hughes, R.T.2
Mayer, B.J.3
Yee, K.4
Woodgett, J.R.5
Avruch, J.6
Kyriakis, J.M.7
Zon, L.I.8
-
253
-
-
27544434183
-
Essential function for the kinase TAK1 in innate and adaptive immune responses
-
Sato S, Sanjo H, Takeda K, Ninomiya-Tsuji J, Yamamoto M, Kawai T, Matsumoto K, Takeuchi O, Akira S. Essential function for the kinase TAK1 in innate and adaptive immune responses. Nat Immunol 6: 1087-1095, 2005.
-
(2005)
Nat Immunol
, vol.6
, pp. 1087-1095
-
-
Sato, S.1
Sanjo, H.2
Takeda, K.3
Ninomiya-Tsuji, J.4
Yamamoto, M.5
Kawai, T.6
Matsumoto, K.7
Takeuchi, O.8
Akira, S.9
-
254
-
-
72449162040
-
Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by NZF domains of TAB2 and TAB3
-
Sato Y, Yoshikawa A, Yamashita M, Yamagata A, Fukai S. Structural basis for specific recognition of Lys 63-linked polyubiquitin chains by NZF domains of TAB2 and TAB3. EMBO J 28: 3903-3909, 2009.
-
(2009)
EMBO J
, vol.28
, pp. 3903-3909
-
-
Sato, Y.1
Yoshikawa, A.2
Yamashita, M.3
Yamagata, A.4
Fukai, S.5
-
255
-
-
0030657770
-
Cloning and characterization of a human STE-20-like protein kinase with unusual cofactor requirements
-
Schinkmann K, Blenis J. Cloning and characterization of a human STE-20-like protein kinase with unusual cofactor requirements. J Biol Chem 272: 28695-28703, 1997.
-
(1997)
J Biol Chem
, vol.272
, pp. 28695-28703
-
-
Schinkmann, K.1
Blenis, J.2
-
256
-
-
0026575932
-
The mechanism of action of cyclosporin A and FK506
-
Schreiber SL, Crabtree GR. The mechanism of action of cyclosporin A and FK506. Immunol Today 13: 136-142, 1992.
-
(1992)
Immunol Today
, vol.13
, pp. 136-142
-
-
Schreiber, S.L.1
Crabtree, G.R.2
-
257
-
-
66549125216
-
A critical role of TAK1 in B-cell receptor-mediated nuclear factor-κB activation
-
Schuman J, Chen Y, Podd A, Yu M, Liu HH, Wen R, Chen ZJ, Wang D. A critical role of TAK1 in B-cell receptor-mediated nuclear factor-κB activation. Blood 113: 4566-4574, 2009.
-
(2009)
Blood
, vol.113
, pp. 4566-4574
-
-
Schuman, J.1
Chen, Y.2
Podd, A.3
Yu, M.4
Liu, H.H.5
Wen, R.6
Chen, Z.J.7
Wang, D.8
-
258
-
-
0029134790
-
Defective induction of stress-activated protein kinase activity in ataxia-telangiectasia cells exposed to ionizing radiation
-
Shafman TD, Saleem A, Kyriakis J, Weichselbaum R, Kharbanda S, Kufe DW. Defective induction of stress-activated protein kinase activity in ataxia-telangiectasia cells exposed to ionizing radiation. Cancer Res 55: 3242-3245, 1995.
-
(1995)
Cancer Res
, vol.55
, pp. 3242-3245
-
-
Shafman, T.D.1
Saleem, A.2
Kyriakis, J.3
Weichselbaum, R.4
Kharbanda, S.5
Kufe, D.W.6
-
259
-
-
0033569918
-
Stress-induced JNK activation is independent of gadd45 induction
-
Shaulian E, Karin M. Stress-induced JNK activation is independent of gadd45 induction. J Biol Chem 274: 29595-29598, 1999.
-
(1999)
J Biol Chem
, vol.274
, pp. 29595-29598
-
-
Shaulian, E.1
Karin, M.2
-
260
-
-
0036098552
-
AP-1 as a regulator of cell life and death
-
Shaulian E, Karin M. AP-1 as a regulator of cell life and death. Nat Cell Biol 4: E131-E136, 2002.
-
(2002)
Nat Cell Biol
, vol.4
-
-
Shaulian, E.1
Karin, M.2
-
261
-
-
0031437885
-
Activation of stress-activated protein kinase/c-Jun N-terminal kinase, but not NF-κB, by the tumor necrosis factor (TNF) receptor 1 through a TNF receptor-associated factor 2- and germinal center kinase related-dependent pathway
-
Shi CS, Kehrl JH. Activation of stress-activated protein kinase/c-Jun N-terminal kinase, but not NF-κB, by the tumor necrosis factor (TNF) receptor 1 through a TNF receptor-associated factor 2- and germinal center kinase related-dependent pathway. J Biol Chem 272: 32102-32107, 1997.
-
(1997)
J Biol Chem
, vol.272
, pp. 32102-32107
-
-
Shi, C.S.1
Kehrl, J.H.2
-
262
-
-
0033568595
-
TNF-mediated activation of the stress-activated protein kinase pathway: TNF receptor-associated factor 2 recruits and activates germinal center kinase related
-
Shi CS, Leonardi A, Kyriakis J, Siebenlist U, Kehrl JH. TNF-mediated activation of the stress-activated protein kinase pathway: TNF receptor-associated factor 2 recruits and activates germinal center kinase related. J Immunol 163: 3279-3285, 1999.
-
(1999)
J Immunol
, vol.163
, pp. 3279-3285
-
-
Shi, C.S.1
Leonardi, A.2
Kyriakis, J.3
Siebenlist, U.4
Kehrl, J.H.5
-
263
-
-
33747758320
-
The mitogen-activated protein kinase kinase kinase kinase GCKR positively regulates canonical and noncanonical Wnt signaling in B lymphocytes
-
Shi CS, Huang NN, Harrison K, Han SB, Kehrl JH. The mitogen-activated protein kinase kinase kinase kinase GCKR positively regulates canonical and noncanonical Wnt signaling in B lymphocytes. Mol Cell Biol 26: 6511-6521, 2006.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 6511-6521
-
-
Shi, C.S.1
Huang, N.N.2
Harrison, K.3
Han, S.B.4
Kehrl, J.H.5
-
264
-
-
0038682002
-
Mechanisms of TGF-β signaling from the membrane to the nucleus
-
Shi Y, Massagué J. Mechanisms of TGF-β signaling from the membrane to the nucleus. Cell 113: 685-700, 2003.
-
(2003)
Cell
, vol.113
, pp. 685-700
-
-
Shi, Y.1
Massagué, J.2
-
265
-
-
10744224857
-
Elimination of protein kinase MK5/PRAK activity by targeted homologous recombination
-
Shi Y, Kotlyarov A, Laabeta K, Gruber AD, Butt E, Marcus K, Meyer HE, Friedrich A, Volk HD, Gaestel M. Elimination of protein kinase MK5/PRAK activity by targeted homologous recombination. Mol Cell Biol 23: 7732-7741, 2003.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 7732-7741
-
-
Shi, Y.1
Kotlyarov, A.2
Laabeta, K.3
Gruber, A.D.4
Butt, E.5
Marcus, K.6
Meyer, H.E.7
Friedrich, A.8
Volk, H.D.9
Gaestel, M.10
-
266
-
-
0029940355
-
TAB1: An activator of the TAK1 MAPKKK in TGF-β signal transduction
-
Shibuya H, Yamaguchi K, Shirakabe K, Tonegawa A, Gotoh Y, Ueno N, Irie K, Nishida E, Matsumoto K. TAB1: an activator of the TAK1 MAPKKK in TGF-β signal transduction. Science 272: 1179-1182, 1996.
-
(1996)
Science
, vol.272
, pp. 1179-1182
-
-
Shibuya, H.1
Yamaguchi, K.2
Shirakabe, K.3
Tonegawa, A.4
Gotoh, Y.5
Ueno, N.6
Irie, K.7
Nishida, E.8
Matsumoto, K.9
-
267
-
-
10344239898
-
Differential activation of ERK, p38, and JNK required for Th1 and Th2 deviation in myelin-reactive T cells induced by altered peptide ligand
-
Singh RA, Zhang JZ. Differential activation of ERK, p38, and JNK required for Th1 and Th2 deviation in myelin-reactive T cells induced by altered peptide ligand. J Immunol 173: 7299-7307, 2004.
-
(2004)
J Immunol
, vol.173
, pp. 7299-7307
-
-
Singh, R.A.1
Zhang, J.Z.2
-
268
-
-
58949093454
-
Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance
-
Singh R, Wang Y, Xiang Y, Tanaka KE, Gaarde WA, Czaja MJ. Differential effects of JNK1 and JNK2 inhibition on murine steatohepatitis and insulin resistance. Hepatology 49: 87-96, 2009.
-
(2009)
Hepatology
, vol.49
, pp. 87-96
-
-
Singh, R.1
Wang, Y.2
Xiang, Y.3
Tanaka, K.E.4
Gaarde, W.A.5
Czaja, M.J.6
-
269
-
-
9044220225
-
3pK, a new mitogenactivated protein kinase-activated protein kinase located in the small cell lung cancer tumor suppressor gene region
-
Sithanandam G, Latif F, Smola U, Bernal RA, Duh FM, Li H, Kuzmin I, Wixle V, Geil L, Shresta S, Lloyd PA, Bader S, Sekido Y, Tartof KD, Kashuba VI, Zabarovsky ER, Dean M, Klein G, Zbar B, Lerman MI, Minna JD, Rapp UR, Allikmets A. 3pK, a new mitogenactivated protein kinase-activated protein kinase located in the small cell lung cancer tumor suppressor gene region. Mol Cell Biol 16: 868-876, 1996.
-
(1996)
Mol Cell Biol
, vol.16
, pp. 868-876
-
-
Sithanandam, G.1
Latif, F.2
Smola, U.3
Bernal, R.A.4
Duh, F.M.5
Li, H.6
Kuzmin, I.7
Wixle, V.8
Geil, L.9
Shresta, S.10
Lloyd, P.A.11
Bader, S.12
Sekido, Y.13
Tartof, K.D.14
Kashuba, V.I.15
Zabarovsky, E.R.16
Dean, M.17
Klein, G.18
Zbar, B.19
Lerman, M.I.20
Minna, J.D.21
Rapp, U.R.22
Allikmets, A.23
more..
-
270
-
-
0025788098
-
Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73
-
Smeal T, Binetruy B, Mercola D, Grover-Bardwick A, Heidecker G, Rapp UR, Karin M. Oncogenic and transcriptional cooperation with Ha-Ras requires phosphorylation of c-Jun on serines 63 and 73. Nature 354: 494-496, 1991.
-
(1991)
Nature
, vol.354
, pp. 494-496
-
-
Smeal, T.1
Binetruy, B.2
Mercola, D.3
Grover-Bardwick, A.4
Heidecker, G.5
Rapp, U.R.6
Karin, M.7
-
271
-
-
35548943962
-
JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity
-
Solinas G, Vilcu C, Neels JG, Bandyopadhyay GK, Luo JL, Naugler W, Grivennikov S, Wynshaw-Boris A, Scadeng M, Olefsky JM, Karin M. JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity. Cell Metab 6: 386-397, 2007.
-
(2007)
Cell Metab
, vol.6
, pp. 386-397
-
-
Solinas, G.1
Vilcu, C.2
Neels, J.G.3
Bandyopadhyay, G.K.4
Luo, J.L.5
Naugler, W.6
Grivennikov, S.7
Wynshaw-Boris, A.8
Scadeng, M.9
Olefsky, J.M.10
Karin, M.11
-
272
-
-
0032054816
-
The mRNA 5' cap-binding protein eIF-4E and control of cell growth
-
Sonenberg N, Gingras AC. The mRNA 5' cap-binding protein eIF-4E and control of cell growth. Curr Opin Cell Biol 10: 268-275, 1998.
-
(1998)
Curr Opin Cell Biol
, vol.10
, pp. 268-275
-
-
Sonenberg, N.1
Gingras, A.C.2
-
273
-
-
33745382457
-
Interleukin-1 stimulated activation of the COT catalytic subunit through the phosphorylation of Thr290 and Ser62
-
Stafford MJ, Morrice NA, Peggie MW, Cohen P. Interleukin-1 stimulated activation of the COT catalytic subunit through the phosphorylation of Thr290 and Ser62. FEBS Lett 580: 4010-4014, 2006.
-
(2006)
FEBS Lett
, vol.580
, pp. 4010-4014
-
-
Stafford, M.J.1
Morrice, N.A.2
Peggie, M.W.3
Cohen, P.4
-
274
-
-
0030805915
-
p38-2, a novel mitogen-activated protein kinase with distinct properties
-
Stein B, Yang MX, Young DB, Janknecht R, Hunter T, Murray BW, Barbosa M. p38-2, a novel mitogen-activated protein kinase with distinct properties. J Biol Chem 272: 19509-19517, 1997.
-
(1997)
J Biol Chem
, vol.272
, pp. 19509-19517
-
-
Stein, B.1
Yang, M.X.2
Young, D.B.3
Janknecht, R.4
Hunter, T.5
Murray, B.W.6
Barbosa, M.7
-
275
-
-
0026733636
-
MAPAKP kinase-2: A novel protein kinase activated by mitogen-activated protein kinase
-
Stokoe D, Campbell DG, Nakielny S, Hidaka H, Leevers S, Marshall C, Cohen P. MAPAKP kinase-2: a novel protein kinase activated by mitogen-activated protein kinase. EMBO J 11: 3985-3994, 1992.
-
(1992)
EMBO J
, vol.11
, pp. 3985-3994
-
-
Stokoe, D.1
Campbell, D.G.2
Nakielny, S.3
Hidaka, H.4
Leevers, S.5
Marshall, C.6
Cohen, P.7
-
276
-
-
0026457201
-
Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins
-
Stokoe D, Engel K, Campbell DG, Cohen P, Gaestel M. Identification of MAPKAP kinase 2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins. FEBS Lett 313: 307-313, 1992.
-
(1992)
FEBS Lett
, vol.313
, pp. 307-313
-
-
Stokoe, D.1
Engel, K.2
Campbell, D.G.3
Cohen, P.4
Gaestel, M.5
-
277
-
-
0032609859
-
Cell crawling two decades after Abercrombie
-
Stossel TP, Hartwig JH, Janmey PA, Kwiatkowski DJ. Cell crawling two decades after Abercrombie. Biochem Soc Symp 65: 267-280, 1999.
-
(1999)
Biochem Soc Symp
, vol.65
, pp. 267-280
-
-
Stossel, T.P.1
Hartwig, J.H.2
Janmey, P.A.3
Kwiatkowski, D.J.4
-
278
-
-
0028291525
-
JNK is involved in signal integration during costimulation of T lymphocytes
-
Su B, Jacinto E, Hibi M, Kallunki T, Karin M, Ben-Neriah Y. JNK is involved in signal integration during costimulation of T lymphocytes. Cell 77: 727-736, 1994.
-
(1994)
Cell
, vol.77
, pp. 727-736
-
-
Su, B.1
Jacinto, E.2
Hibi, M.3
Kallunki, T.4
Karin, M.5
Ben-Neriah, Y.6
-
279
-
-
0030907935
-
NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain
-
Su YC, Han J, Xu S, Cobb M, Skolnik EY. NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain. EMBO J 16: 1279-1290, 1997.
-
(1997)
EMBO J
, vol.16
, pp. 1279-1290
-
-
Su, Y.C.1
Han, J.2
Xu, S.3
Cobb, M.4
Skolnik, E.Y.5
-
280
-
-
0032146918
-
The Drosophila Ste20-related kinase misshapen is required for embryonic dorsal closure and acts through a JNK MAPK module on an evolutionalrily conserved signaling pathway
-
Su YC, Treisman JE, Skolnik EY. The Drosophila Ste20-related kinase misshapen is required for embryonic dorsal closure and acts through a JNK MAPK module on an evolutionalrily conserved signaling pathway. Genes Dev 12: 2371-2380, 1998.
-
(1998)
Genes Dev
, vol.12
, pp. 2371-2380
-
-
Su, Y.C.1
Treisman, J.E.2
Skolnik, E.Y.3
-
281
-
-
0033634977
-
TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway
-
Takaesu G, Kishida S, Hiyama A, Yamaguchi K, Shibuya H, Irie K, Ninomiya-Tsuji J, Matsumoto K. TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway. Mol Cell 5: 649-650, 2000.
-
(2000)
Mol Cell
, vol.5
, pp. 649-650
-
-
Takaesu, G.1
Kishida, S.2
Hiyama, A.3
Yamaguchi, K.4
Shibuya, H.5
Irie, K.6
Ninomiya-Tsuji, J.7
Matsumoto, K.8
-
282
-
-
34147186130
-
Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1
-
Takeda K, Shimozono R, Noguchi T, Umeda T, Morimoto Y, Naguro I, Tobiume K, Saitoh M, Matsuzawa A, Ichijo H. Apoptosis signal-regulating kinase (ASK) 2 functions as a mitogen-activated protein kinase kinase kinase in a heteromeric complex with ASK1. J Biol Chem 282: 7522-7531, 2007.
-
(2007)
J Biol Chem
, vol.282
, pp. 7522-7531
-
-
Takeda, K.1
Shimozono, R.2
Noguchi, T.3
Umeda, T.4
Morimoto, Y.5
Naguro, I.6
Tobiume, K.7
Saitoh, M.8
Matsuzawa, A.9
Ichijo, H.10
-
283
-
-
0030851904
-
A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathways
-
Takekawa M, Posas F, Saito H. A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathways. EMBO J 16: 4973-4982, 1997.
-
(1997)
EMBO J
, vol.16
, pp. 4973-4982
-
-
Takekawa, M.1
Posas, F.2
Saito, H.3
-
284
-
-
0032514967
-
A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK
-
Takekawa M, Saito H. A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK. Cell 95: 521-530, 1998.
-
(1998)
Cell
, vol.95
, pp. 521-530
-
-
Takekawa, M.1
Saito, H.2
-
285
-
-
0029790656
-
FGF and stress regulate CREB and ATF1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2
-
Tan Y, Rouse J, Zhang A, Cariaty S, Cohen P, Comb M. FGF and stress regulate CREB and ATF1 via a pathway involving p38 MAP kinase and MAPKAP kinase-2. EMBO J 15: 4629-4642, 1996.
-
(1996)
EMBO J
, vol.15
, pp. 4629-4642
-
-
Tan, Y.1
Rouse, J.2
Zhang, A.3
Cariaty, S.4
Cohen, P.5
Comb, M.6
-
286
-
-
0035891320
-
Inhibition of JNK activation through NF-κB target genes
-
Tang G, Minemoto Y, Dibling B, Purcell NH, Li Z, Karin M, Lin A. Inhibition of JNK activation through NF-κB target genes. Nature 414: 313-317, 2001.
-
(2001)
Nature
, vol.414
, pp. 313-317
-
-
Tang, G.1
Minemoto, Y.2
Dibling, B.3
Purcell, N.H.4
Li, Z.5
Karin, M.6
Lin, A.7
-
287
-
-
46949097612
-
TAK1 is required for the survival of hematopoietic cells and hepatocytes in mice
-
Tang M, Wei X, Guo Y, Breslin P, Zhang S, Zhang S, Wei W, Xia Z, Diaz M, Akira S, Zhang J. TAK1 is required for the survival of hematopoietic cells and hepatocytes in mice. J Exp Med 205: 1611-1619, 2008.
-
(2008)
J Exp Med
, vol.205
, pp. 1611-1619
-
-
Tang, M.1
Wei, X.2
Guo, Y.3
Breslin, P.4
Zhang, S.5
Zhang, S.6
Wei, W.7
Xia, Z.8
Diaz, M.9
Akira, S.10
Zhang, J.11
-
288
-
-
0033788484
-
A conserved docking motif in MAP kinases common to substrates, activators and regulators
-
Tanoue T, Adachi M, Moriguchi T, Nishida E. A conserved docking motif in MAP kinases common to substrates, activators and regulators. Nature Cell Biol 2: 110-116, 2000.
-
(2000)
Nature Cell Biol
, vol.2
, pp. 110-116
-
-
Tanoue, T.1
Adachi, M.2
Moriguchi, T.3
Nishida, E.4
-
289
-
-
0037400611
-
Molecular recognitions in the MAP kinase cascades
-
Tanoue T, Nishida E. Molecular recognitions in the MAP kinase cascades. Cell Signal 15: 455-462, 2003.
-
(2003)
Cell Signal
, vol.15
, pp. 455-462
-
-
Tanoue, T.1
Nishida, E.2
-
290
-
-
0032473569
-
A new Rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-κB signalling pathways
-
Tapon N, Nagata K, Lamarche N, Hall A. A new Rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-κB signalling pathways. EMBO J 17: 1395-1404, 1998.
-
(1998)
EMBO J
, vol.17
, pp. 1395-1404
-
-
Tapon, N.1
Nagata, K.2
Lamarche, N.3
Hall, A.4
-
291
-
-
0030462564
-
MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6
-
Tibbles LA, Ing YL, Kiefer F, Chan J, Iscove N, Woodgett JR, Lassam NJ. MLK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6. EMBO J 15: 7026-7035, 1996.
-
(1996)
EMBO J
, vol.15
, pp. 7026-7035
-
-
Tibbles, L.A.1
Ing, Y.L.2
Kiefer, F.3
Chan, J.4
Iscove, N.5
Woodgett, J.R.6
Lassam, N.J.7
-
292
-
-
0035065836
-
ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis
-
Tobiume K, Matsuzawa A, Takahashi T, Nishitoh H, Morita K, Takeda K, Minowa O, Miyazono K, Noda T, Ichijo H. ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis. EMBO Rep 2: 222-228, 2001.
-
(2001)
EMBO Rep
, vol.2
, pp. 222-228
-
-
Tobiume, K.1
Matsuzawa, A.2
Takahashi, T.3
Nishitoh, H.4
Morita, K.5
Takeda, K.6
Minowa, O.7
Miyazono, K.8
Noda, T.9
Ichijo, H.10
-
294
-
-
0034607702
-
Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway
-
Tournier C, Hess P, Yang DD, Xu J, Turner TK, Nimnual A, Bar-Sagi D, Jones SN, Flavell RA, Davis RJ. Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. Science 288: 870-873, 2000.
-
(2000)
Science
, vol.288
, pp. 870-873
-
-
Tournier, C.1
Hess, P.2
Yang, D.D.3
Xu, J.4
Turner, T.K.5
Nimnual, A.6
Bar-Sagi, D.7
Jones, S.N.8
Flavell, R.A.9
Davis, R.J.10
-
295
-
-
0029935418
-
Regulation of transcription by MAP kinase cascades
-
Treisman R. Regulation of transcription by MAP kinase cascades. Curr Opin Cell Biol 8: 205-215, 1996.
-
(1996)
Curr Opin Cell Biol
, vol.8
, pp. 205-215
-
-
Treisman, R.1
-
296
-
-
0031059833
-
A novel human SPS1/STE20 homologue, KHS, activates Jun N-terminal kinase
-
Tung RM, Blenis JJ. A novel human SPS1/STE20 homologue, KHS, activates Jun N-terminal kinase. Oncogene 14: 653-659, 1997.
-
(1997)
Oncogene
, vol.14
, pp. 653-659
-
-
Tung, R.M.1
Blenis, J.J.2
-
297
-
-
77956271160
-
Combined deficiency for MAP kinase interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development
-
Ueda T, Sasaki M, Elia AJ, Chio II, Hamada K, Fukunaga R, Mak TW. Combined deficiency for MAP kinase interacting kinase 1 and 2 (Mnk1 and Mnk2) delays tumor development. Proc Natl Acad Sci USA 107: 13984-13990, 2010.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 13984-13990
-
-
Ueda, T.1
Sasaki, M.2
Elia, A.J.3
Chio, I.I.4
Hamada, K.5
Fukunaga, R.6
Mak, T.W.7
-
298
-
-
52349105273
-
A predominant role for parenchymal c-Jun amino terminal kinase (JNK) in the regulation of systemic insulin sensitivity
-
Vallerie SN, Furuhashi M, Fucho R, Hotamisligil G. A predominant role for parenchymal c-Jun amino terminal kinase (JNK) in the regulation of systemic insulin sensitivity. PLOS One 3: e3151, 2008.
-
(2008)
PLOS One
, vol.3
-
-
Vallerie, S.N.1
Furuhashi, M.2
Fucho, R.3
Hotamisligil, G.4
-
301
-
-
33344477350
-
Chemical genetic analysis of the time course of signal transduction by JNK
-
Ventura JJ, Hübner A, Zhang C, Flavell RA, Shokat KM, Davis RJ. Chemical genetic analysis of the time course of signal transduction by JNK. Mol Cell 21: 701-710, 2006.
-
(2006)
Mol Cell
, vol.21
, pp. 701-710
-
-
Ventura, J.J.1
Hübner, A.2
Zhang, C.3
Flavell, R.A.4
Shokat, K.M.5
Davis, R.J.6
-
302
-
-
33645531744
-
Convergence of itch-induced ubiquitination with MEKK1- JNK signaling in Th2 tolerance and airway inflammation
-
Venuprasad K, Elly C, Gao M, Salek-Ardakani S, Harada Y, Luo JL, Yang C, Croft M, Inoue K, Karin M, Liu YC. Convergence of itch-induced ubiquitination with MEKK1- JNK signaling in Th2 tolerance and airway inflammation. J Clin Invest 116: 1117-1126, 2006.
-
(2006)
J Clin Invest
, vol.116
, pp. 1117-1126
-
-
Venuprasad, K.1
Elly, C.2
Gao, M.3
Salek-Ardakani, S.4
Harada, Y.5
Luo, J.L.6
Yang, C.7
Croft, M.8
Inoue, K.9
Karin, M.10
Liu, Y.C.11
-
303
-
-
33746111852
-
The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function
-
Wan YY, Chi H, Xie M, Schneider MD, Flavell RA. The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function. Nat Immunol 7: 851-858, 2006.
-
(2006)
Nat Immunol
, vol.7
, pp. 851-858
-
-
Wan, Y.Y.1
Chi, H.2
Xie, M.3
Schneider, M.D.4
Flavell, R.A.5
-
304
-
-
0035913278
-
TAK1 is a ubiquitindependent kinase of MKK and IKK
-
Wang C, Deng L, Hong M, Akkaraju GR, Inoue J, Chen ZJ. TAK1 is a ubiquitindependent kinase of MKK and IKK. Nature 412: 346-351, 2001.
-
(2001)
Nature
, vol.412
, pp. 346-351
-
-
Wang, C.1
Deng, L.2
Hong, M.3
Akkaraju, G.R.4
Inoue, J.5
Chen, Z.J.6
-
305
-
-
4043110739
-
Evidence of MKK4 pro-oncogenic activity in breast and pancreatic tumors
-
Wang L, Pan Y, Dai JL. Evidence of MKK4 pro-oncogenic activity in breast and pancreatic tumors. Oncogene 23: 5978-5985, 2004.
-
(2004)
Oncogene
, vol.23
, pp. 5978-5985
-
-
Wang, L.1
Pan, Y.2
Dai, J.L.3
-
306
-
-
79956207794
-
MEKK3 regulates IFN-checkentity /checkentity production in T cells through the Rac1/2-dependent MAPK cascades
-
Wang S, Zhang F, Chen F, Liu D, Zheng Y, Zhang Y, Dong C, Su B. MEKK3 regulates IFN-checkentity /checkentity production in T cells through the Rac1/2-dependent MAPK cascades. J Immunol 186: 5791-5800, 2011.
-
(2011)
J Immunol
, vol.186
, pp. 5791-5800
-
-
Wang, S.1
Zhang, F.2
Chen, F.3
Liu, D.4
Zheng, Y.5
Zhang, Y.6
Dong, C.7
Su, B.8
-
307
-
-
0029938805
-
Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP kinase
-
Wang X, Ron D. Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP kinase. Science 272: 1347-1349, 1996.
-
(1996)
Science
, vol.272
, pp. 1347-1349
-
-
Wang, X.1
Ron, D.2
-
308
-
-
0033570086
-
Holbrook NJ gadd45 is not required for activation of c-Jun N-terminal kinase or p38 during acute stress
-
Wang X, Gorospe M, Holbrook NJ gadd45 is not required for activation of c-Jun N-terminal kinase or p38 during acute stress. J Biol Chem 274: 29599-29602, 1999.
-
(1999)
J Biol Chem
, vol.274
, pp. 29599-29602
-
-
Wang, X.1
Gorospe, M.2
-
309
-
-
0029954102
-
Molecular cloning and characterization of a novel protein kinase with a catalytic domain homologous to mitogen-activated protein kinase kinase kinase
-
Wang XS, Diener K, Jannuzzi D, Trollinger D, Tan TH, Lichenstein H, Zukowski M, Yao Z. Molecular cloning and characterization of a novel protein kinase with a catalytic domain homologous to mitogen-activated protein kinase kinase kinase. J Biol Chem 271: 31607-31611, 1996.
-
(1996)
J Biol Chem
, vol.271
, pp. 31607-31611
-
-
Wang, X.S.1
Diener, K.2
Jannuzzi, D.3
Trollinger, D.4
Tan, T.H.5
Lichenstein, H.6
Zukowski, M.7
Yao, Z.8
-
310
-
-
0030756286
-
Molecular cloning and characterization of a novel p38 mitogen-activated protein kinase
-
23688-23674
-
Wang XS, Diener K, Manthey CL, Wang Sw, Rosenzweig B, Bray J, Delaney J, Cole CN, Chan-Hui PY, Mantlo N, Lichenstein HS, Zukowski M, Yao Z. Molecular cloning and characterization of a novel p38 mitogen-activated protein kinase. J Biol Chem 272: 23688-23674, 1997.
-
(1997)
J Biol Chem
, vol.272
-
-
Wang, X.S.1
Diener, K.2
Manthey, C.L.3
Wang, S.W.4
Rosenzweig, B.5
Bray, J.6
Delaney, J.7
Cole, C.N.8
Chan-Hui, P.Y.9
Mantlo, N.10
Lichenstein, H.S.11
Zukowski, M.12
Yao, Z.13
-
311
-
-
0030977269
-
Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2
-
Waskiewicz AJ, Flynn A, Proud CG, Cooper JA. Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2. EMBO J 16: 1909-1920, 1997.
-
(1997)
EMBO J
, vol.16
, pp. 1909-1920
-
-
Waskiewicz, A.J.1
Flynn, A.2
Proud, C.G.3
Cooper, J.A.4
-
312
-
-
0032981328
-
Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo
-
Waskiewicz AJ, Johnson JC, Penn B, Mahalingam M, Kimball SR, Cooper JA. Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo. Mol Cell Biol 19: 1871-1880, 1999.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 1871-1880
-
-
Waskiewicz, A.J.1
Johnson, J.C.2
Penn, B.3
Mahalingam, M.4
Kimball, S.R.5
Cooper, J.A.6
-
313
-
-
58149288281
-
Tpl2 kinase regulates T cell interferon-gamma production and host resistance to Toxoplasma gondii
-
Watford WT, Hissong BD, Durant LO, Yamane H, Muul LM, Kanno Y, Tato CM, Ramos HL, Berger AE, Meilke L, Pesu M, Solomon B, Frucht DM, Paul WE, Sher A, Jankovic D, Tsichlis PN, O'Shea JJ. Tpl2 kinase regulates T cell interferon-gamma production and host resistance to Toxoplasma gondii. J Exp Med 205: 2803-2812, 2008.
-
(2008)
J Exp Med
, vol.205
, pp. 2803-2812
-
-
Watford, W.T.1
Hissong, B.D.2
Durant, L.O.3
Yamane, H.4
Muul, L.M.5
Kanno, Y.6
Tato, C.M.7
Ramos, H.L.8
Berger, A.E.9
Meilke, L.10
Pesu, M.11
Solomon, B.12
Frucht, D.M.13
Paul, W.E.14
Sher, A.15
Jankovic, D.16
Tsichlis, P.N.17
O'Shea, J.J.18
-
314
-
-
73949143744
-
Ablation of tumor progression locus 2 promotes a type 2 Th cell response in ovalbumin-immunized mice
-
Watford WT, Wang CC, Tsatsanis C, Mielke LA, Eliopoulos AG, Daskalakis C, Charles N, Odom S, Rivera J, O'Shea J, Tsichlis PN. Ablation of tumor progression locus 2 promotes a type 2 Th cell response in ovalbumin-immunized mice. J Immunol 184: 105-113, 2010.
-
(2010)
J Immunol
, vol.184
, pp. 105-113
-
-
Watford, W.T.1
Wang, C.C.2
Tsatsanis, C.3
Mielke, L.A.4
Eliopoulos, A.G.5
Daskalakis, C.6
Charles, N.7
Odom, S.8
Rivera, J.9
O'Shea, J.10
Tsichlis, P.N.11
-
315
-
-
44949237240
-
JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy
-
Wei Y, Pattingre S, Sinha S, Bassik M, Levine B. JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy. Mol Cell 30: 678-688, 2008.
-
(2008)
Mol Cell
, vol.30
, pp. 678-688
-
-
Wei, Y.1
Pattingre, S.2
Sinha, S.3
Bassik, M.4
Levine, B.5
-
316
-
-
53549089861
-
Dual role of JNK1-mediated phosphorylation of Bcl-2 in autophagy and apoptosis regulation
-
Wei Y, Sinha S, Levine B. Dual role of JNK1-mediated phosphorylation of Bcl-2 in autophagy and apoptosis regulation. Autophagy 4: 949-951, 2008.
-
(2008)
Autophagy
, vol.4
, pp. 949-951
-
-
Wei, Y.1
Sinha, S.2
Levine, B.3
-
318
-
-
37249042829
-
Dissecting eIF4E action in tumorigenesis
-
Wendel HG, Silva RL, Malina A, Mills JR, Zhu H, Ueda T, Watanabe-Fukunaga R, Fukunaga R, Teruya-Feldstein J, Pelletier J, Lowe SW. Dissecting eIF4E action in tumorigenesis. Genes Dev 21: 3232-3237, 2007.
-
(2007)
Genes Dev
, vol.21
, pp. 3232-3237
-
-
Wendel, H.G.1
Silva, R.L.2
Malina, A.3
Mills, J.R.4
Zhu, H.5
Ueda, T.6
Watanabe-Fukunaga, R.7
Fukunaga, R.8
Teruya-Feldstein, J.9
Pelletier, J.10
Lowe, S.W.11
-
319
-
-
79955532516
-
TLR signalling augments macrophage bactericidal activity through mitochondrial ROS
-
West PA, Brodsky IE, Rahner C, Woo DK, Erdjument-Bromage H, Tempst P, Walsh MC, Choi Y, Shadel GS, Ghosh S. TLR signalling augments macrophage bactericidal activity through mitochondrial ROS. Nature 471: 476-480, 2011.
-
(2011)
Nature
, vol.471
, pp. 476-480
-
-
West, P.A.1
Brodsky, I.E.2
Rahner, C.3
Woo, D.K.4
Erdjument-Bromage, H.5
Tempst, P.6
Walsh, M.C.7
Choi, Y.8
Shadel, G.S.9
Ghosh, S.10
-
320
-
-
33847754623
-
The JNK signal transduction pathway
-
Weston CR, Davis RJ. The JNK signal transduction pathway. Curr Opin Cell Biol 19, 142-149, 2007.
-
(2007)
Curr Opin Cell Biol
, vol.19
, pp. 142-149
-
-
Weston, C.R.1
Davis, R.J.2
-
321
-
-
0036710280
-
IRS proteins and the common path to diabetes
-
White MF. IRS proteins and the common path to diabetes. Am J Physiol Endocrinol Metab 283: E413-E422, 2002.
-
(2002)
Am J Physiol Endocrinol Metab
, vol.283
-
-
White, M.F.1
-
322
-
-
0029125757
-
Integration of MAP kinase signal transduction pathways at the serum response element
-
Whitmarsh AJ, Shore P, Sharrocks AD, Davis RJ. Integration of MAP kinase signal transduction pathways at the serum response element. Science 269: 403-407, 1995.
-
(1995)
Science
, vol.269
, pp. 403-407
-
-
Whitmarsh, A.J.1
Shore, P.2
Sharrocks, A.D.3
Davis, R.J.4
-
323
-
-
0032508714
-
A mammalian scaffold complex that selectively mediates MAP kinase activation
-
Whitmarsh AJ, Cavanagh J, Tournier C, Yasuda J, Davis RJ. A mammalian scaffold complex that selectively mediates MAP kinase activation. Science 281: 1671-1674, 1998.
-
(1998)
Science
, vol.281
, pp. 1671-1674
-
-
Whitmarsh, A.J.1
Cavanagh, J.2
Tournier, C.3
Yasuda, J.4
Davis, R.J.5
-
324
-
-
0035883958
-
Requirement of the JIP1 scaffold protein for stress-induced JNK activation
-
Whitmarsh AJ, Kuan CY, Kennedy NJ, Kelkar N, Haydar TF, Mordes JP, Appel M, Rossini AA, Jones SN, Flavell RA, Rakic P, Davis RJ. Requirement of the JIP1 scaffold protein for stress-induced JNK activation. Genes Dev 15: 2421-2432, 2001.
-
(2001)
Genes Dev
, vol.15
, pp. 2421-2432
-
-
Whitmarsh, A.J.1
Kuan, C.Y.2
Kennedy, N.J.3
Kelkar, N.4
Haydar, T.F.5
Mordes, J.P.6
Appel, M.7
Rossini, A.A.8
Jones, S.N.9
Flavell, R.A.10
Rakic, P.11
Davis, R.J.12
-
325
-
-
34248597048
-
Role of mitogen-activated protein kinase kinase 4 in cancer
-
Whitmarsh AJ, Davis RJ. Role of mitogen-activated protein kinase kinase 4 in cancer. Oncogene 26: 3172-3184, 2007.
-
(2007)
Oncogene
, vol.26
, pp. 3172-3184
-
-
Whitmarsh, A.J.1
Davis, R.J.2
-
326
-
-
34548309196
-
Identification of POSH2, a novel homologue of the c-Jun N-terminal kinase scaffold protein POSH
-
Wilhelm M, Kukekov NV, Xu Z, Greene LA. Identification of POSH2, a novel homologue of the c-Jun N-terminal kinase scaffold protein POSH. Dev Neurosci 29: 355-362, 2007.
-
(2007)
Dev Neurosci
, vol.29
, pp. 355-362
-
-
Wilhelm, M.1
Kukekov, N.V.2
Xu, Z.3
Greene, L.A.4
-
327
-
-
0033568608
-
The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich regiontargeted mechanism
-
Winzen R, Kracht M, Ritter B, Wilhelm A, Chen CY, Shyu AB, Muller M, Gaestel M, Resch K, Holtmann H. The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich regiontargeted mechanism. EMBO J 18: 4969-4980, 1999.
-
(1999)
EMBO J
, vol.18
, pp. 4969-4980
-
-
Winzen, R.1
Kracht, M.2
Ritter, B.3
Wilhelm, A.4
Chen, C.Y.5
Shyu, A.B.6
Muller, M.7
Gaestel, M.8
Resch, K.9
Holtmann, H.10
-
328
-
-
0037449717
-
Ubiquitylation of MEKK1 inhibits its phosphorylation of MKK1 and MKK4 and activation of the ERK1/2 and JNK pathways
-
Witowski JA, Johnson GL. Ubiquitylation of MEKK1 inhibits its phosphorylation of MKK1 and MKK4 and activation of the ERK1/2 and JNK pathways. J Biol Chem 278: 1403-1406, 2003.
-
(2003)
J Biol Chem
, vol.278
, pp. 1403-1406
-
-
Witowski, J.A.1
Johnson, G.L.2
-
330
-
-
0032213146
-
JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino terminal extension
-
Xia Y, Wu Z, Su B, Murray B, Karin M. JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino terminal extension. Genes Dev 12: 3369-3381, 1998.
-
(1998)
Genes Dev
, vol.12
, pp. 3369-3381
-
-
Xia, Y.1
Wu, Z.2
Su, B.3
Murray, B.4
Karin, M.5
-
331
-
-
33846130923
-
MEKK1 mediates the ubiquitination and degradation of c-Jun in response to osmotic stress
-
Xia Y, Wang J, Xu S, Johnson GL, Hunter T, Lu Z. MEKK1 mediates the ubiquitination and degradation of c-Jun in response to osmotic stress. Mol Cell Biol 27: 510-517, 2007.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 510-517
-
-
Xia, Y.1
Wang, J.2
Xu, S.3
Johnson, G.L.4
Hunter, T.5
Lu, Z.6
-
332
-
-
69949093459
-
Direct activation of protein kinases by unanchored polyubiquitin chains
-
Xia ZP, Sun L, Chen X, Pineda G, Jiang X, Adhikari A, Zeng W, Chen ZJ. Direct activation of protein kinases by unanchored polyubiquitin chains. Nature 461: 114-119, 2009.
-
(2009)
Nature
, vol.461
, pp. 114-119
-
-
Xia, Z.P.1
Sun, L.2
Chen, X.3
Pineda, G.4
Jiang, X.5
Adhikari, A.6
Zeng, W.7
Chen, Z.J.8
-
333
-
-
0029789643
-
Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase
-
Xing J, Ginty DD, Greenberg ME. Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase. Science 273: 959-963, 1996.
-
(1996)
Science
, vol.273
, pp. 959-963
-
-
Xing, J.1
Ginty, D.D.2
Greenberg, M.E.3
-
334
-
-
79951720176
-
JNK regulates FoxO-dependent autophagy in neurons
-
Xu P, Das M, Reilly J, Davis RJ. JNK regulates FoxO-dependent autophagy in neurons. Genes Dev 25: 310-322, 2011.
-
(2011)
Genes Dev
, vol.25
, pp. 310-322
-
-
Xu, P.1
Das, M.2
Reilly, J.3
Davis, R.J.4
-
335
-
-
0029942952
-
Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain
-
Xu S, Robbins DJ, Christerson LB, English JM, Vanderbilt C, Cobb MH. Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain. Proc Natl Acad Sci USA 93: 5291-5295, 1996.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 5291-5295
-
-
Xu, S.1
Robbins, D.J.2
Christerson, L.B.3
English, J.M.4
Vanderbilt, C.5
Cobb, M.H.6
-
336
-
-
0029551805
-
Identification of a member of the MAPKKK family as a potential mediator of TGF-β signal transduction
-
Yamaguchi K, Shirakabi K, Shibuya H, Irie K, Oishi I, Ueno N, Taniguchi T, Nishida E, Matsumoto K. Identification of a member of the MAPKKK family as a potential mediator of TGF-β signal transduction. Science 270: 2008-2011, 1995.
-
(1995)
Science
, vol.270
, pp. 2008-2011
-
-
Yamaguchi, K.1
Shirakabi, K.2
Shibuya, H.3
Irie, K.4
Oishi, I.5
Ueno, N.6
Taniguchi, T.7
Nishida, E.8
Matsumoto, K.9
-
337
-
-
0033521529
-
XIAP, a cellular member of the inhibitor of apoptosis protein family links the receptors to TAB1-TAK1 in the BMP signaling pathway
-
Yamaguchi K, Nagai Si Ninomiya-Tsuji J, Nishita M, Tamai K, Irie K, Ueno N, Nishida E, Shibuya H, Matsumoto K. XIAP, a cellular member of the inhibitor of apoptosis protein family links the receptors to TAB1-TAK1 in the BMP signaling pathway. EMBO J 18: 179-187, 1999.
-
(1999)
EMBO J
, vol.18
, pp. 179-187
-
-
Yamaguchi, K.1
Nagai, S.2
Ninomiya-Tsuji, J.3
Nishita, M.4
Tamai, K.5
Irie, K.6
Ueno, N.7
Nishida, E.8
Shibuya, H.9
Matsumoto, K.10
-
338
-
-
0028670788
-
Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1
-
Yan M, Dai T, Deak JC, Kyriakis JM, Zon LI, Woodgett JR, Templeton DJ. Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1. Nature 372: 798-800, 1994.
-
(1994)
Nature
, vol.372
, pp. 798-800
-
-
Yan, M.1
Dai, T.2
Deak, J.C.3
Kyriakis, J.M.4
Zon, L.I.5
Woodgett, J.R.6
Templeton, D.J.7
-
339
-
-
0030780804
-
Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the JNK3 gene
-
Yang DD, Kuan CY, Whitmarsh AJ, Roncon M, Zheng TS, Davis RJ, Rakic P, Flavell RA. Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the JNK3 gene. Nature 389: 865-870, 1997.
-
(1997)
Nature
, vol.389
, pp. 865-870
-
-
Yang, D.D.1
Kuan, C.Y.2
Whitmarsh, A.J.3
Roncon, M.4
Zheng, T.S.5
Davis, R.J.6
Rakic, P.7
Flavell, R.A.8
-
340
-
-
0034050739
-
Mekk3 is essential for early embryonic cardiovascular development
-
Yang J, Boerm M M, McCarthy M, Bucana C, Fidler IJ, Zhuang Y, Su B. Mekk3 is essential for early embryonic cardiovascular development. Nat Genet 24: 309-313, 2000.
-
(2000)
Nat Genet
, vol.24
, pp. 309-313
-
-
Yang, J.1
Boerm, M.M.2
McCarthy, M.3
Bucana, C.4
Fidler, I.J.5
Zhuang, Y.6
Su, B.7
-
341
-
-
0032536816
-
Differential targeting of MAP kinases to the ETS-domain transcription factor Elk-1
-
Yang SH, Whitmarsh AJ, Davis RJ, Sharrocks AD. Differential targeting of MAP kinases to the ETS-domain transcription factor Elk-1. EMBO J 17: 1740-1749, 1998.
-
(1998)
EMBO J
, vol.17
, pp. 1740-1749
-
-
Yang, S.H.1
Whitmarsh, A.J.2
Davis, R.J.3
Sharrocks, A.D.4
-
342
-
-
77951214016
-
Mammalian autophagy: Core molecular machinery and signaling regulation
-
Yang Z, Klionsky DJ. Mammalian autophagy: core molecular machinery and signaling regulation. Curr Opin Cell Biol 22: 124-131, 2010.
-
(2010)
Curr Opin Cell Biol
, vol.22
, pp. 124-131
-
-
Yang, Z.1
Klionsky, D.J.2
-
343
-
-
15144349962
-
Activation of stress-activated protein kinases/c-Jun N-terminal kinases (SAPKs/JNKs) by a novel mitogen-activated protein kinase kinase (MKK7)
-
Yao Z, Deiner K, Wang XS, Zukowski M, Matsumoto G, Zhou G, Mo R, Sasaki Nishina H, Hui CC, Tan TH, Woodgett JR, Penninger JM. Activation of stress-activated protein kinases/c-Jun N-terminal kinases (SAPKs/JNKs) by a novel mitogen-activated protein kinase kinase (MKK7). J Biol Chem 272: 32378-32383, 1997.
-
(1997)
J Biol Chem
, vol.272
, pp. 32378-32383
-
-
Yao, Z.1
Deiner, K.2
Wang, X.S.3
Zukowski, M.4
Matsumoto, G.5
Zhou, G.6
Mo, R.7
Sasaki Nishina, H.8
Hui, C.C.9
Tan, T.H.10
Woodgett, J.R.11
Penninger, J.M.12
-
344
-
-
0033593470
-
A novel human STE20-related protein kinase, HGK, that specifically activates the c-Jun N-terminal kinase signaling pathway
-
Yao Z, Zhou G, Wang XS, Brown A, Diener K, Gan H, Tan TH. A novel human STE20-related protein kinase, HGK, that specifically activates the c-Jun N-terminal kinase signaling pathway. J Biol Chem 274: 2118-2125, 1999.
-
(1999)
J Biol Chem
, vol.274
, pp. 2118-2125
-
-
Yao, Z.1
Zhou, G.2
Wang, X.S.3
Brown, A.4
Diener, K.5
Gan, H.6
Tan, T.H.7
-
345
-
-
0032825497
-
The JIP group of mitogenactivated protein kinase scaffold proteins
-
Yasuda J, Whitmarsh AJ, Cavanagh J, Sharma M, Davis RJ. The JIP group of mitogenactivated protein kinase scaffold proteins. Mol Cell Biol 19: 7245-7254, 1999.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 7245-7254
-
-
Yasuda, J.1
Whitmarsh, A.J.2
Cavanagh, J.3
Sharma, M.4
Davis, R.J.5
-
347
-
-
0032483967
-
Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption
-
Yujiri T, Sather S, Fanger GR, Johnson GL. Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption. Science 282: 1911-1914, 1998.
-
(1998)
Science
, vol.282
, pp. 1911-1914
-
-
Yujiri, T.1
Sather, S.2
Fanger, G.R.3
Johnson, G.L.4
-
348
-
-
35548930283
-
The MAPK-activated kinase Rsk controls an acute toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways
-
Zaru R, Ronkina N, Gaestel M, Arthur JS, Watts C. The MAPK-activated kinase Rsk controls an acute toll-like receptor signaling response in dendritic cells and is activated through two distinct pathways. Nat Immunol 8: 1227-1235, 2007.
-
(2007)
Nat Immunol
, vol.8
, pp. 1227-1235
-
-
Zaru, R.1
Ronkina, N.2
Gaestel, M.3
Arthur, J.S.4
Watts, C.5
-
349
-
-
0032953307
-
Regulation of the MEF2 family of transcription factors by p38
-
Zhao M, New L, Kravchenko VV, Kato Y, Gram H, di Padova F, Olson EN, Ulevitch RJ, Han J. Regulation of the MEF2 family of transcription factors by p38. Mol Cell Biol 19: 21-30, 1999.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 21-30
-
-
Zhao, M.1
New, L.2
Kravchenko, V.V.3
Kato, Y.4
Gram, H.5
di Padova, F.6
Olson, E.N.7
Ulevitch, R.J.8
Han, J.9
-
350
-
-
26244432962
-
Identification of Raf-1 S471 as a novel phosphorylation site critical for Raf-1 and B-Raf kinase activities and for MEK binding
-
Zhu J, Balan V, Bronisz A, Balan K, Sun H, Leicht DT, Luo Z, Qin J, Avruch J, Tzivion G. Identification of Raf-1 S471 as a novel phosphorylation site critical for Raf-1 and B-Raf kinase activities and for MEK binding. Mol Biol Cell 16: 4733-4744, 2005.
-
(2005)
Mol Biol Cell
, vol.16
, pp. 4733-4744
-
-
Zhu, J.1
Balan, V.2
Bronisz, A.3
Balan, K.4
Sun, H.5
Leicht, D.T.6
Luo, Z.7
Qin, J.8
Avruch, J.9
Tzivion, G.10
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