Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex

Science

Volumn 321, Issue 5889, 2008, Pages 663-668

  Matsuzawa, Atsushi ^a   Tseng, Ping Hui ^a   Vallabhapurapu, Sivakumar ^a   Luo, Jun Li ^a   Zhang, Weizhou ^a   Wang, Haopeng ^b   Vignali, Dario A A ^b   Gallagher, Ewen ^c   Karin, Michael ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^c IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; CYTOKINE RECEPTOR; I KAPPA B KINASE GAMMA; INHIBITOR OF APOPTOSIS PROTEIN 1; INHIBITOR OF APOPTOSIS PROTEIN 2; MEMBRANE RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE 1; PROTEASOME; PROTEIN KINASE; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 3; UBIQUITIN CONJUGATING ENZYME 13;

APOPTOSIS; CYTOPLASM; ENZYME ACTIVITY; IMMUNE RESPONSE; PROTEIN; TRANSLOCATION;

ARTICLE; B LYMPHOCYTE; CYTOPLASM; CYTOSOL; ENZYME ACTIVATION; ENZYME ISOLATION; INNATE IMMUNITY; LYMPHOCYTE ACTIVATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION;

ANIMALS; ANTIGENS, CD40; B-LYMPHOCYTES; CELL MEMBRANE; CYTOPLASM; ENZYME ACTIVATION; I-KAPPA B KINASE; INHIBITOR OF APOPTOSIS PROTEINS; LYMPHOCYTE ACTIVATION; MAP KINASE KINASE KINASE 1; MAP KINASE KINASE KINASES; MAP KINASE SIGNALING SYSTEM; MICE; PROTEASOME ENDOPEPTIDASE COMPLEX; SIGNAL TRANSDUCTION; TNF RECEPTOR-ASSOCIATED FACTOR 2; TNF RECEPTOR-ASSOCIATED FACTOR 3; TNF RECEPTOR-ASSOCIATED FACTOR 6; UBIQUITIN-CONJUGATING ENZYMES; UBIQUITINATION;

EID: 48749090228     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1157340     Document Type: Article

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35. We thank V. M. Dixit (Genentech) for his excellent suggestions, X. Wang (University of Texas Southwestern Medical School) for SM, J. DiDonato (Cleveland Clinic) and G. Courtois (INSERM U697) for IKKγ-deficient cells, R. Fonseca (Mayo Clinic) for c-IAP-deficient cells, and J. Reed and Z. Ronai (Burnham) for c-IAP2 and TRAF2 expression vectors, respectively. Work was supported by NIH grant AI043477 and a Leukemia and Lymphoma Society SCOR (7332-06) project to M.K., who is an American Cancer Society Research Professor. A.M., P.-H.T., and J.-L.L. were supported in part by The Mochida Memorial Foundation for Medical and Pharmaceutical Research, American Lung Association of California, and Life Science Foundation, respectively. H.W. and D.A.A.V were supported by the NIH (AI52199), a Cancer Center Support CORE grant (CA21765), and the American Lebanese Syrian Associated Charities (ALSAC).