-
1
-
-
0037043658
-
Inflammatory bowel disease
-
Podolsky D.K. Inflammatory bowel disease. N Engl J Med 347 (2002) 417-429
-
(2002)
N Engl J Med
, vol.347
, pp. 417-429
-
-
Podolsky, D.K.1
-
2
-
-
0031781603
-
Inflammatory bowel disease: etiology and pathogenesis
-
Fiocchi C. Inflammatory bowel disease: etiology and pathogenesis. Gastroenterology 115 (1998) 182-205
-
(1998)
Gastroenterology
, vol.115
, pp. 182-205
-
-
Fiocchi, C.1
-
3
-
-
0035080617
-
The risk of colorectal cancer in ulcerative colitis: a meta-analysis
-
Eaden J.A., Abrams K.R., and Mayberry J.F. The risk of colorectal cancer in ulcerative colitis: a meta-analysis. Gut 48 (2001) 526-535
-
(2001)
Gut
, vol.48
, pp. 526-535
-
-
Eaden, J.A.1
Abrams, K.R.2
Mayberry, J.F.3
-
4
-
-
3042599473
-
Inflammation and cancer, IV: colorectal cancer in inflammatory bowel disease: the role of inflammation
-
Itzkowitz S.H., and Yio X. Inflammation and cancer, IV: colorectal cancer in inflammatory bowel disease: the role of inflammation. Am J Physiol Gastrointest Liver Physiol 287 (2004) G7-G17
-
(2004)
Am J Physiol Gastrointest Liver Physiol
, vol.287
-
-
Itzkowitz, S.H.1
Yio, X.2
-
5
-
-
0035282334
-
Mammalian MAP kinase signalling cascades
-
Chang L., and Karin M. Mammalian MAP kinase signalling cascades. Nature 410 (2001) 37-40
-
(2001)
Nature
, vol.410
, pp. 37-40
-
-
Chang, L.1
Karin, M.2
-
6
-
-
34547154349
-
p38 MAP-kinases pathway regulation, function and role in human diseases
-
Cuenda A., and Rousseau S. p38 MAP-kinases pathway regulation, function and role in human diseases. Biochim Biophys Acta 1773 (2007) 1358-1375
-
(2007)
Biochim Biophys Acta
, vol.1773
, pp. 1358-1375
-
-
Cuenda, A.1
Rousseau, S.2
-
7
-
-
0037216749
-
Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets
-
Hommes D.W., Peppelenbosch M.P., and van Deventer S.J. Mitogen activated protein (MAP) kinase signal transduction pathways and novel anti-inflammatory targets. Gut 52 (2003) 144-151
-
(2003)
Gut
, vol.52
, pp. 144-151
-
-
Hommes, D.W.1
Peppelenbosch, M.P.2
van Deventer, S.J.3
-
8
-
-
0036961905
-
From extracellular to intracellular targets, inhibiting MAP kinases in treatment of Crohn's disease
-
Van Den Blink B., Ten Hove T., Van Den Brink G.R., et al. From extracellular to intracellular targets, inhibiting MAP kinases in treatment of Crohn's disease. Ann N Y Acad Sci 973 (2002) 349-358
-
(2002)
Ann N Y Acad Sci
, vol.973
, pp. 349-358
-
-
Van Den Blink, B.1
Ten Hove, T.2
Van Den Brink, G.R.3
-
10
-
-
0037180757
-
Inflammation and cancer
-
Coussens L.M., and Werb Z. Inflammation and cancer. Nature 420 (2002) 860-867
-
(2002)
Nature
, vol.420
, pp. 860-867
-
-
Coussens, L.M.1
Werb, Z.2
-
11
-
-
36549082403
-
Toll-like receptor-4 promotes the development of colitis-associated colorectal tumors
-
Fukata M., Chen A., Vamadevan A.S., et al. Toll-like receptor-4 promotes the development of colitis-associated colorectal tumors. Gastroenterology 133 (2007) 1869-1881
-
(2007)
Gastroenterology
, vol.133
, pp. 1869-1881
-
-
Fukata, M.1
Chen, A.2
Vamadevan, A.S.3
-
12
-
-
14444281569
-
Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways
-
Ichijo H., Nishida E., Irie K., et al. Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science 275 (1997) 90-94
-
(1997)
Science
, vol.275
, pp. 90-94
-
-
Ichijo, H.1
Nishida, E.2
Irie, K.3
-
13
-
-
0032158987
-
ASK1 is essential for JNK/SAPK activation by TRAF2
-
Nishitoh H., Saitoh M., Mochida Y., et al. ASK1 is essential for JNK/SAPK activation by TRAF2. Mol Cell 2 (1998) 389-395
-
(1998)
Mol Cell
, vol.2
, pp. 389-395
-
-
Nishitoh, H.1
Saitoh, M.2
Mochida, Y.3
-
14
-
-
1642487129
-
Involvement of ASK1 in Ca2+-induced p38 MAP kinase activation
-
Takeda K., Matsuzawa A., Nishitoh H., et al. Involvement of ASK1 in Ca2+-induced p38 MAP kinase activation. EMBO Rep 5 (2004) 161-166
-
(2004)
EMBO Rep
, vol.5
, pp. 161-166
-
-
Takeda, K.1
Matsuzawa, A.2
Nishitoh, H.3
-
15
-
-
20644433073
-
ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity
-
Matsuzawa A., Saegusa K., Noguchi T., et al. ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity. Nat Immunol 6 (2005) 587-592
-
(2005)
Nat Immunol
, vol.6
, pp. 587-592
-
-
Matsuzawa, A.1
Saegusa, K.2
Noguchi, T.3
-
16
-
-
65449146296
-
ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis
-
Iriyama T., Takeda K., Nakamura H., et al. ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis. EMBO J 28 (2009) 843-853
-
(2009)
EMBO J
, vol.28
, pp. 843-853
-
-
Iriyama, T.1
Takeda, K.2
Nakamura, H.3
-
17
-
-
0035065836
-
ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis
-
Tobiume K., Matsuzawa A., Takahashi T., et al. ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis. EMBO Rep 2 (2001) 222-228
-
(2001)
EMBO Rep
, vol.2
, pp. 222-228
-
-
Tobiume, K.1
Matsuzawa, A.2
Takahashi, T.3
-
18
-
-
0034795561
-
Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-gamma and TNF-alpha production
-
Siegmund B., Fantuzzi G., Rieder F., et al. Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-gamma and TNF-alpha production. Am J Physiol Regul Integr Comp Physiol 281 (2001) R1264-R1273
-
(2001)
Am J Physiol Regul Integr Comp Physiol
, vol.281
-
-
Siegmund, B.1
Fantuzzi, G.2
Rieder, F.3
-
19
-
-
13244277880
-
Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing
-
Maeda S., Hsu L.C., Liu H., et al. Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing. Science 307 (2005) 734-738
-
(2005)
Science
, vol.307
, pp. 734-738
-
-
Maeda, S.1
Hsu, L.C.2
Liu, H.3
-
20
-
-
0035082973
-
Different subsets of enteric bacteria induce and perpetuate experimental colitis in rats and mice
-
Rath H.C., Schultz M., Freitag R., et al. Different subsets of enteric bacteria induce and perpetuate experimental colitis in rats and mice. Infect Immun 69 (2001) 2277-2285
-
(2001)
Infect Immun
, vol.69
, pp. 2277-2285
-
-
Rath, H.C.1
Schultz, M.2
Freitag, R.3
-
21
-
-
0027164517
-
The role of the eae gene of enterohemorrhagic Escherichia coli in intimate attachment in vitro and in a porcine model
-
Donnenberg M.S., Tzipori S., McKee M.L., et al. The role of the eae gene of enterohemorrhagic Escherichia coli in intimate attachment in vitro and in a porcine model. J Clin Invest 92 (1993) 1418-1424
-
(1993)
J Clin Invest
, vol.92
, pp. 1418-1424
-
-
Donnenberg, M.S.1
Tzipori, S.2
McKee, M.L.3
-
22
-
-
34548225362
-
NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta
-
Greten F.R., Arkan M.C., Bollrath J., et al. NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta. Cell 130 (2007) 918-931
-
(2007)
Cell
, vol.130
, pp. 918-931
-
-
Greten, F.R.1
Arkan, M.C.2
Bollrath, J.3
-
23
-
-
24944554790
-
Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis--CREB and NF-kappaB as key regulators
-
Park J.M., Greten F.R., Wong A., et al. Signaling pathways and genes that inhibit pathogen-induced macrophage apoptosis--CREB and NF-kappaB as key regulators. Immunity 23 (2005) 319-329
-
(2005)
Immunity
, vol.23
, pp. 319-329
-
-
Park, J.M.1
Greten, F.R.2
Wong, A.3
-
24
-
-
24144494513
-
Important role of apoptosis signal-regulating kinase 1 in ischemia-induced angiogenesis
-
Izumi Y., Kim-Mitsuyama S., Yoshiyama M., et al. Important role of apoptosis signal-regulating kinase 1 in ischemia-induced angiogenesis. Arterioscler Thromb Vasc Biol 25 (2005) 1877-1883
-
(2005)
Arterioscler Thromb Vasc Biol
, vol.25
, pp. 1877-1883
-
-
Izumi, Y.1
Kim-Mitsuyama, S.2
Yoshiyama, M.3
-
25
-
-
0036606540
-
ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats
-
Nishitoh H., Matsuzawa A., Tobiume K., et al. ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats. Genes Dev 16 (2002) 1345-1355
-
(2002)
Genes Dev
, vol.16
, pp. 1345-1355
-
-
Nishitoh, H.1
Matsuzawa, A.2
Tobiume, K.3
-
26
-
-
9144231898
-
Targeted deletion of apoptosis signal-regulating kinase 1 attenuates left ventricular remodeling
-
Yamaguchi O., Higuchi Y., Hirotani S., et al. Targeted deletion of apoptosis signal-regulating kinase 1 attenuates left ventricular remodeling. Proc Natl Acad Sci U S A 100 (2003) 15883-15888
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, pp. 15883-15888
-
-
Yamaguchi, O.1
Higuchi, Y.2
Hirotani, S.3
-
27
-
-
53049105071
-
Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation
-
Nakagawa H., Maeda S., Hikiba Y., et al. Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation. Gastroenterology 135 (2008) 1311-1321
-
(2008)
Gastroenterology
, vol.135
, pp. 1311-1321
-
-
Nakagawa, H.1
Maeda, S.2
Hikiba, Y.3
-
28
-
-
0036142395
-
Inhibition of stress-activated MAP kinases induces clinical improvement in moderate to severe Crohn's disease
-
Hommes D., van den Blink B., Plasse T., et al. Inhibition of stress-activated MAP kinases induces clinical improvement in moderate to severe Crohn's disease. Gastroenterology 122 (2002) 7-14
-
(2002)
Gastroenterology
, vol.122
, pp. 7-14
-
-
Hommes, D.1
van den Blink, B.2
Plasse, T.3
-
29
-
-
23444447597
-
Specific inhibition of c-Raf activity by semapimod induces clinical remission in severe Crohn's disease
-
Lowenberg M., Verhaar A., van den Blink B., et al. Specific inhibition of c-Raf activity by semapimod induces clinical remission in severe Crohn's disease. J Immunol 175 (2005) 2293-2300
-
(2005)
J Immunol
, vol.175
, pp. 2293-2300
-
-
Lowenberg, M.1
Verhaar, A.2
van den Blink, B.3
-
30
-
-
33644756429
-
Oral p38 mitogen-activated protein kinase inhibition with BIRB 796 for active Crohn's disease: a randomized, double-blind, placebo-controlled trial
-
Schreiber S., Feagan B., D'Haens G., et al. Oral p38 mitogen-activated protein kinase inhibition with BIRB 796 for active Crohn's disease: a randomized, double-blind, placebo-controlled trial. Clin Gastroenterol Hepatol 4 (2006) 325-334
-
(2006)
Clin Gastroenterol Hepatol
, vol.4
, pp. 325-334
-
-
Schreiber, S.1
Feagan, B.2
D'Haens, G.3
-
31
-
-
0036278884
-
Dichotomal role of inhibition of p38 MAPK with SB 203580 in experimental colitis
-
ten Hove T., van den Blink B., Pronk I., et al. Dichotomal role of inhibition of p38 MAPK with SB 203580 in experimental colitis. Gut 50 (2002) 507-512
-
(2002)
Gut
, vol.50
, pp. 507-512
-
-
ten Hove, T.1
van den Blink, B.2
Pronk, I.3
-
32
-
-
9444228220
-
Inhibition of p38 MAP kinase- and RICK/NF-kappaB-signaling suppresses inflammatory bowel disease
-
Hollenbach E., Neumann M., Vieth M., et al. Inhibition of p38 MAP kinase- and RICK/NF-kappaB-signaling suppresses inflammatory bowel disease. FASEB J 18 (2004) 1550-1552
-
(2004)
FASEB J
, vol.18
, pp. 1550-1552
-
-
Hollenbach, E.1
Neumann, M.2
Vieth, M.3
-
33
-
-
63449088019
-
FR167653, a p38 mitogen-activated protein kinase inhibitor, aggravates experimental colitis in mice
-
Nishimura T., Andoh A., Nishida A., et al. FR167653, a p38 mitogen-activated protein kinase inhibitor, aggravates experimental colitis in mice. World J Gastroenterol 14 (2008) 5851-5856
-
(2008)
World J Gastroenterol
, vol.14
, pp. 5851-5856
-
-
Nishimura, T.1
Andoh, A.2
Nishida, A.3
-
34
-
-
33645828828
-
The specific JNK inhibitor SP600125 targets tumour necrosis factor-alpha production and epithelial cell apoptosis in acute murine colitis
-
Assi K., Pillai R., Gomez-Munoz A., et al. The specific JNK inhibitor SP600125 targets tumour necrosis factor-alpha production and epithelial cell apoptosis in acute murine colitis. Immunology 118 (2006) 112-121
-
(2006)
Immunology
, vol.118
, pp. 112-121
-
-
Assi, K.1
Pillai, R.2
Gomez-Munoz, A.3
-
35
-
-
34247847785
-
Genetic deletion of JNK1 and JNK2 aggravates the DSS-induced colitis in mice
-
Chromik A.M., Muller A.M., Korner J., et al. Genetic deletion of JNK1 and JNK2 aggravates the DSS-induced colitis in mice. J Invest Surg 20 (2007) 23-33
-
(2007)
J Invest Surg
, vol.20
, pp. 23-33
-
-
Chromik, A.M.1
Muller, A.M.2
Korner, J.3
-
36
-
-
17644377258
-
How neutrophils kill microbes
-
Segal A.W. How neutrophils kill microbes. Annu Rev Immunol 23 (2005) 197-223
-
(2005)
Annu Rev Immunol
, vol.23
, pp. 197-223
-
-
Segal, A.W.1
-
37
-
-
4844227764
-
Antimicrobial reactive oxygen and nitrogen species: concepts and controversies
-
Fang F.C. Antimicrobial reactive oxygen and nitrogen species: concepts and controversies. Nat Rev Microbiol 2 (2004) 820-832
-
(2004)
Nat Rev Microbiol
, vol.2
, pp. 820-832
-
-
Fang, F.C.1
-
38
-
-
0032080283
-
Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1
-
Saitoh M., Nishitoh H., Fujii M., et al. Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. EMBO J 17 (1998) 2596-2606
-
(1998)
EMBO J
, vol.17
, pp. 2596-2606
-
-
Saitoh, M.1
Nishitoh, H.2
Fujii, M.3
-
39
-
-
1642617628
-
The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4
-
Hsu L.C., Park J.M., Zhang K., et al. The protein kinase PKR is required for macrophage apoptosis after activation of Toll-like receptor 4. Nature 428 (2004) 341-345
-
(2004)
Nature
, vol.428
, pp. 341-345
-
-
Hsu, L.C.1
Park, J.M.2
Zhang, K.3
-
40
-
-
4043088499
-
IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer
-
Greten F.R., Eckmann L., Greten T.F., et al. IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 118 (2004) 285-296
-
(2004)
Cell
, vol.118
, pp. 285-296
-
-
Greten, F.R.1
Eckmann, L.2
Greten, T.F.3
-
41
-
-
70349652354
-
Effectiveness of IkappaB kinase inhibitors in murine colitis-associated tumorigenesis
-
Hayakawa Y., Maeda S., Nakagawa H., et al. Effectiveness of IkappaB kinase inhibitors in murine colitis-associated tumorigenesis. J Gastroenterol 44 (2009) 935-943
-
(2009)
J Gastroenterol
, vol.44
, pp. 935-943
-
-
Hayakawa, Y.1
Maeda, S.2
Nakagawa, H.3
-
42
-
-
38849171267
-
Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis
-
Popivanova B.K., Kitamura K., Wu Y., et al. Blocking TNF-alpha in mice reduces colorectal carcinogenesis associated with chronic colitis. J Clin Invest 118 (2008) 560-570
-
(2008)
J Clin Invest
, vol.118
, pp. 560-570
-
-
Popivanova, B.K.1
Kitamura, K.2
Wu, Y.3
|