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Volumn 6, Issue 4, 2005, Pages 396-402

The autoimmune suppressor Gadd45α inhibits the T cell alternative p38 activation pathway

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE ZAP 70; CELL CYCLE PROTEIN; GADD45A PROTEIN, MOUSE; LYMPHOCYTE ANTIGEN RECEPTOR; NUCLEAR PROTEIN; PROTEIN TYROSINE KINASE; TYROSINE; ZAP70 PROTEIN, MOUSE;

EID: 16844366591     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni1176     Document Type: Article
Times cited : (89)

References (42)
  • 1
    • 0033547359 scopus 로고    scopus 로고
    • Cytokine response gene 6 induces p21 and regulates both cell growth and arrest
    • Fan, W., Richter, G., Cereseto, A., Beadling, C. & Smith, K.A. Cytokine response gene 6 induces p21 and regulates both cell growth and arrest. Oncogene 18, 6573-6582 (1999).
    • (1999) Oncogene , vol.18 , pp. 6573-6582
    • Fan, W.1    Richter, G.2    Cereseto, A.3    Beadling, C.4    Smith, K.A.5
  • 2
    • 0024436187 scopus 로고
    • Mammalian genes coordinately regulate by growth arrest signals and DNA-damaging agents
    • Fornace, A.J., Jr. et al. Mammalian genes coordinately regulate by growth arrest signals and DNA-damaging agents. Mol. Cell. Biol. 9, 4196-4203 (1989).
    • (1989) Mol. Cell. Biol. , vol.9 , pp. 4196-4203
    • Fornace Jr., A.J.1
  • 4
    • 0034743912 scopus 로고    scopus 로고
    • H1 cells
    • H1 cells. Immunity 14, 583-590 (2001).
    • (2001) Immunity , vol.14 , pp. 583-590
    • Lu, B.1
  • 5
    • 0035261399 scopus 로고    scopus 로고
    • IL-18-stimulated GADD45β required in cytokine-induced, but not TCR-induced, IFN-γ production
    • Yang, J., Zhu, H., Murphy, T.L., Ouyang, W. & Murphy, K.M. IL-18-stimulated GADD45β required in cytokine-induced, but not TCR-induced, IFN-γ production. Nat. Immunol. 2, 157-164 (2001).
    • (2001) Nat. Immunol. , vol.2 , pp. 157-164
    • Yang, J.1    Zhu, H.2    Murphy, T.L.3    Ouyang, W.4    Murphy, K.M.5
  • 6
    • 0346496028 scopus 로고    scopus 로고
    • Gadd45β is important for perpetuating cognate and inflammatory signals in T cells
    • Lu, B., Ferrandino, A.F. & Flavell, R.A. Gadd45β is important for perpetuating cognate and inflammatory signals in T cells. Nat. Immunol. 5, 38-44 (2004).
    • (2004) Nat. Immunol. , vol.5 , pp. 38-44
    • Lu, B.1    Ferrandino, A.F.2    Flavell, R.A.3
  • 7
    • 0034744537 scopus 로고    scopus 로고
    • Gadd45γ is dispensable for normal mouse development and T-cell proliferation
    • Hoffmeyer, A., Piekorz, R., Moriggl, R. & Ihle, J.N. Gadd45γ is dispensable for normal mouse development and T-cell proliferation. Mol. Cell. Biol. 21, 3137-3143 (2001).
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 3137-3143
    • Hoffmeyer, A.1    Piekorz, R.2    Moriggl, R.3    Ihle, J.N.4
  • 8
    • 0344604528 scopus 로고    scopus 로고
    • Genomic instability in Gadd45a-deficient mice
    • Hollander, M.C. et al. Genomic instability in Gadd45a-deficient mice. Nat. Genet. 23, 176-184 (1999).
    • (1999) Nat. Genet. , vol.23 , pp. 176-184
    • Hollander, M.C.1
  • 9
    • 0035866787 scopus 로고    scopus 로고
    • Dimethylbenzanthracene carcinogenesis in Gadd45a-null mice is associated with decreased DNA repair and increased mutation frequency
    • Hollander, M.C. et al. Dimethylbenzanthracene carcinogenesis in Gadd45a-null mice is associated with decreased DNA repair and increased mutation frequency. Cancer Res. 61, 2487-2491 (2001).
    • (2001) Cancer Res. , vol.61 , pp. 2487-2491
    • Hollander, M.C.1
  • 10
    • 0036231177 scopus 로고    scopus 로고
    • Mice lacking the p53-Eefector gene Gadd45a develop a lupus-like syndrome
    • Salvador, J.M. et al. Mice lacking the p53-Eefector gene Gadd45a develop a lupus-like syndrome. Immunity 16, 499-508 (2002).
    • (2002) Immunity , vol.16 , pp. 499-508
    • Salvador, J.M.1
  • 11
    • 0035366079 scopus 로고    scopus 로고
    • MAP-kinase signaling pathways in T cells
    • Rincon, M. MAP-kinase signaling pathways in T cells. Curr. Opin. Immunol. 13, 339-345 (2001).
    • (2001) Curr. Opin. Immunol. , vol.13 , pp. 339-345
    • Rincon, M.1
  • 12
    • 16844367955 scopus 로고    scopus 로고
    • Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases
    • advance online publication, 27 February (10.1038/ni1177)
    • Salvador, J.M. et al. Alternative p38 activation pathway mediated by T cell receptor-proximal tyrosine kinases. Nat. Immunol. advance online publication, 27 February 2005 (doi:10.1038/ni1177).
    • (2005) Nat. Immunol.
    • Salvador, J.M.1
  • 13
    • 0032514967 scopus 로고    scopus 로고
    • A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK
    • Takekawa, M. & Saito, H. A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK. Cell 95, 521-530 (1998).
    • (1998) Cell , vol.95 , pp. 521-530
    • Takekawa, M.1    Saito, H.2
  • 14
    • 0036275374 scopus 로고    scopus 로고
    • Regulation of MTK1/ MEKK4 kinase activity by its N-terminal autoinhibitory domain and GADD45 binding
    • Mita, H., Tsutsui, J., Takekawa, M., Witten, E.A. & Saito, H. Regulation of MTK1/ MEKK4 kinase activity by its N-terminal autoinhibitory domain and GADD45 binding. Mol. Cell. Biol. 22, 4544-4555 (2002).
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 4544-4555
    • Mita, H.1    Tsutsui, J.2    Takekawa, M.3    Witten, E.A.4    Saito, H.5
  • 15
    • 2342486760 scopus 로고    scopus 로고
    • GADD45beta/GADD45gamma and MEKK4 comprise a genetic pathway mediating STAT4-independent IFNγ production in T cells
    • Chi, H., Lu, B., Takekawa, M., Davis, R.J. & Flavell, R.A. GADD45beta/GADD45gamma and MEKK4 comprise a genetic pathway mediating STAT4-independent IFNγ production in T cells. EMBO J. 23, 1576-1586 (2004).
    • (2004) EMBO J. , vol.23 , pp. 1576-1586
    • Chi, H.1    Lu, B.2    Takekawa, M.3    Davis, R.J.4    Flavell, R.A.5
  • 16
    • 0034598346 scopus 로고    scopus 로고
    • 2-terminal kinase (Jnk) gene expression during T cell activation
    • 2-terminal kinase (Jnk) gene expression during T cell activation. J. Exp. Med. 191, 139-146 (2000).
    • (2000) J. Exp. Med. , vol.191 , pp. 139-146
    • Weiss, L.1
  • 18
    • 0035282334 scopus 로고    scopus 로고
    • Mammalian MAP kinase signalling cascades
    • Chang, L. & Karin, M. Mammalian MAP kinase signalling cascades. Nature 410, 37-40 (2001).
    • (2001) Nature , vol.410 , pp. 37-40
    • Chang, L.1    Karin, M.2
  • 19
    • 0033535584 scopus 로고    scopus 로고
    • Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta
    • Giroux, S. et al. Embryonic death of Mek1-deficient mice reveals a role for this kinase in angiogenesis in the labyrinthine region of the placenta. Curr. Biol. 9, 369-372 (1999).
    • (1999) Curr. Biol. , vol.9 , pp. 369-372
    • Giroux, S.1
  • 20
    • 0028859281 scopus 로고
    • Selective requirement for MAP kinase activation in thymocyte differentiation
    • Alberola-Ila, J., Forbush, K.A., Seger, R., Krebs, E.G. & Perlmutter, R.M. Selective requirement for MAP kinase activation in thymocyte differentiation. Nature 373, 620-623 (1995).
    • (1995) Nature , vol.373 , pp. 620-623
    • Alberola-Ila, J.1    Forbush, K.A.2    Seger, R.3    Krebs, E.G.4    Perlmutter, R.M.5
  • 21
    • 17144458301 scopus 로고    scopus 로고
    • Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice
    • Pagès, G. et al. Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice. Science 286, 1374-1377 (1999).
    • (1999) Science , vol.286 , pp. 1374-1377
    • Pagès, G.1
  • 22
    • 0038246249 scopus 로고    scopus 로고
    • Loss of oncogenic H-ras-induced cell cycle arrest and p38 mitogen-activated protein kinase activation by disruption of Gadd45a
    • Bulavin, D.V., Kovalsky, O., Hollander, M.C. & Fornace, A.J.J. Loss of oncogenic H-ras-induced cell cycle arrest and p38 mitogen-activated protein kinase activation by disruption of Gadd45a. Mol. Cell. Biol. 23, 3859-3871 (2003).
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 3859-3871
    • Bulavin, D.V.1    Kovalsky, O.2    Hollander, M.C.3    Fornace, A.J.J.4
  • 23
    • 0032935664 scopus 로고    scopus 로고
    • Mitogen-activated protein kinases: Specific messages from ubiquitous messengers
    • Schaeffer, H.J. & Weber, M.J. Mitogen-activated protein kinases: specific messages from ubiquitous messengers. Mol. Cell. Biol. 19, 2435-2444 (1999).
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 2435-2444
    • Schaeffer, H.J.1    Weber, M.J.2
  • 24
    • 0034604093 scopus 로고    scopus 로고
    • JNK is required for effector T-cell function but not for T-cell activation
    • Dong, C. et al. JNK is required for effector T-cell function but not for T-cell activation. Nature 405, 91-94 (2000).
    • (2000) Nature , vol.405 , pp. 91-94
    • Dong, C.1
  • 25
    • 0034644522 scopus 로고    scopus 로고
    • Signal transduction by the JNK group of MAP kinases
    • Davis, R.J. Signal transduction by the JNK group of MAP kinases. Cell 103, 239-252 (2000).
    • (2000) Cell , vol.103 , pp. 239-252
    • Davis, R.J.1
  • 26
    • 0041660960 scopus 로고    scopus 로고
    • Mechanism of p38 MAP kinase activation in vivo
    • Brancho, D. et al. Mechanism of p38 MAP kinase activation in vivo. Genes Dev. 17, 1969-1978 (2003).
    • (2003) Genes Dev. , vol.17 , pp. 1969-1978
    • Brancho, D.1
  • 27
    • 0036687249 scopus 로고    scopus 로고
    • Differential involvement of p38 mitogen-activated protein kinase kinases MKK3 and MKK6 in T-cell apoptosis
    • Tanaka, N. et al. Differential involvement of p38 mitogen-activated protein kinase kinases MKK3 and MKK6 in T-cell apoptosis. EMBO Rep. 3, 785-791 (2002).
    • (2002) EMBO Rep. , vol.3 , pp. 785-791
    • Tanaka, N.1
  • 28
    • 0030756286 scopus 로고    scopus 로고
    • Molecular cloning and characterization of a novel p38 mitogen-activated protein kinase
    • Wang, X.S. et al. Molecular cloning and characterization of a novel p38 mitogen-activated protein kinase. J. Biol. Chem. 272, 23668-23674 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 23668-23674
    • Wang, X.S.1
  • 29
    • 0029551805 scopus 로고
    • Identification of a member of the MAPKKK family as a potential mediator of TGF-β signal transduction
    • Yamaguchi, K. et al. Identification of a member of the MAPKKK family as a potential mediator of TGF-β signal transduction. Science 270, 2008-2011 (1995).
    • (1995) Science , vol.270 , pp. 2008-2011
    • Yamaguchi, K.1
  • 30
    • 14444281569 scopus 로고    scopus 로고
    • Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways
    • Ichijo, H. et al. Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science 275, 90-94 (1997).
    • (1997) Science , vol.275 , pp. 90-94
    • Ichijo, H.1
  • 31
    • 0029954102 scopus 로고    scopus 로고
    • Molecular cloning and characterization of a novel protein kinase with a catalytic domain homologous to mitogen-activated protein kinase kinase kinase
    • Wang, X.S. et al. Molecular cloning and characterization of a novel protein kinase with a catalytic domain homologous to mitogen-activated protein kinase kinase kinase. J. Biol. Chem. 271, 31607-31611 (1996).
    • (1996) J. Biol. Chem. , vol.271 , pp. 31607-31611
    • Wang, X.S.1
  • 32
    • 0037083375 scopus 로고    scopus 로고
    • MAPKK-independent activation of p38α mediated by TAB1-dependent autophosphorylation of p38α
    • Ge, B. et al. MAPKK-independent activation of p38α mediated by TAB1-dependent autophosphorylation of p38α. Science 295, 1291-1294 (2002).
    • (2002) Science , vol.295 , pp. 1291-1294
    • Ge, B.1
  • 33
    • 0037115421 scopus 로고    scopus 로고
    • Gadd45a protects against UV irradiation-induced skin tumors, and promotes apoptosis and stress signaling via MAPK and p53
    • Hildesheim, J. et al. Gadd45a protects against UV irradiation-induced skin tumors, and promotes apoptosis and stress signaling via MAPK and p53. Cancer Res. 62, 7305-7315 (2002).
    • (2002) Cancer Res. , vol.62 , pp. 7305-7315
    • Hildesheim, J.1
  • 34
    • 0035229933 scopus 로고    scopus 로고
    • Disruption of T cell signaling networks and development by Grb2 haploid insufficiency
    • Gong, Q. et al. Disruption of T cell signaling networks and development by Grb2 haploid insufficiency. Nat. Immunol. 2, 29-36 (2001).
    • (2001) Nat. Immunol. , vol.2 , pp. 29-36
    • Gong, Q.1
  • 35
    • 17444438194 scopus 로고    scopus 로고
    • A p38 MAP kinase inhibitor SB203580 inhibits CD28-dependent T cell proliferation and IL-2 production
    • Ward, S.G., Parry, R.V., Matthews, J. & O'Neill, L. A p38 MAP kinase inhibitor SB203580 inhibits CD28-dependent T cell proliferation and IL-2 production. Biochem. Soc. Trans. 25, 304S (1997).
    • (1997) Biochem. Soc. Trans. , vol.25
    • Ward, S.G.1    Parry, R.V.2    Matthews, J.3    O'Neill, L.4
  • 36
    • 0032524919 scopus 로고    scopus 로고
    • Lymphocyte activation signals for interleukin-2 production involve activation of MKK6-p38 and MKK7-SAPK/JNK signaling pathways sensitive to cyclosporin
    • Matsuda, S., Moriguchi, T., Koyasu, S. & Nishida, E. T lymphocyte activation signals for interleukin-2 production involve activation of MKK6-p38 and MKK7-SAPK/JNK signaling pathways sensitive to cyclosporin A. J. Biol. Chem. 273, 12378-12382 (1998).
    • (1998) A. J. Biol. Chem. , vol.273 , pp. 12378-12382
    • Matsuda, S.1    Moriguchi, T.2    Koyasu, S.3    Nishida, E.T.4
  • 37
    • 0033120052 scopus 로고    scopus 로고
    • P38 mitogen-activated protein kinase mediates signal integration of TCR/CD28 costimulation in primary murine T cells
    • Zhang, J. et al. p38 mitogen-activated protein kinase mediates signal integration of TCR/CD28 costimulation in primary murine T cells. J. Immunol. 162, 3819-3829 (1999).
    • (1999) J. Immunol. , vol.162 , pp. 3819-3829
    • Zhang, J.1
  • 38
    • 0035102237 scopus 로고    scopus 로고
    • Selective pharmacological inhibitors reveal differences between Thy-1- and T cell receptor-mediated signal transduction in mouse T lymphocytes
    • Haeryfar, S.M. & Hoskin, D.W. Selective pharmacological inhibitors reveal differences between Thy-1- and T cell receptor-mediated signal transduction in mouse T lymphocytes. Int. Immunopharmacol. 1, 689-698 (2001).
    • (2001) Int. Immunopharmacol. , vol.1 , pp. 689-698
    • Haeryfar, S.M.1    Hoskin, D.W.2
  • 39
    • 0034098326 scopus 로고    scopus 로고
    • Immunosuppressive drugs: The first 50 years and a glance forward
    • Allison, A.C. Immunosuppressive drugs: the first 50 years and a glance forward. Immunopharmacology 47, 63-83 (2000).
    • (2000) Immunopharmacology , vol.47 , pp. 63-83
    • Allison, A.C.1
  • 40
    • 0034045949 scopus 로고    scopus 로고
    • Inhibition of p38 MAP kinase as a therapeutic strategy
    • Lee, J.C. et al. Inhibition of p38 MAP kinase as a therapeutic strategy. Immunopharmacology 47, 185-201 (2000).
    • (2000) Immunopharmacology , vol.47 , pp. 185-201
    • Lee, J.C.1
  • 42
    • 0033529121 scopus 로고    scopus 로고
    • Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45
    • Zhan, Q. et al. Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45. Oncogene 18, 2892-2900 (1999).
    • (1999) Oncogene , vol.18 , pp. 2892-2900
    • Zhan, Q.1


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