-
1
-
-
0028605318
-
A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
-
Lee J.C. Laydon J.T. McDonnell P.C. Gallagher T.F. Kumar S. Green D. McNulty D. Blumenthal M.J. Heys J.R. Landvatter S.W. et al. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis Nature 372 1994 739-746
-
(1994)
Nature
, vol.372
, pp. 739-746
-
-
Lee, J.C.1
Laydon, J.T.2
McDonnell, P.C.3
Gallagher, T.F.4
Kumar, S.5
Green, D.6
McNulty, D.7
Blumenthal, M.J.8
Heys, J.R.9
Landvatter, S.W.10
-
2
-
-
0033965158
-
The p38 signal transduction pathway: Activation and function
-
Ono K. Han J. The p38 signal transduction pathway: activation and function Cell Signal 12 2000 1-13
-
(2000)
Cell Signal
, vol.12
, pp. 1-13
-
-
Ono, K.1
Han, J.2
-
3
-
-
0142026209
-
p38 MAP kinases: Key signalling molecules as therapeutic targets for inflammatory diseases
-
Kumar S. Boehm J. Lee J.C. p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases Nat Rev Drug Discov 2 2003 717-726
-
(2003)
Nat. Rev. Drug Discov.
, vol.2
, pp. 717-726
-
-
Kumar, S.1
Boehm, J.2
Lee, J.C.3
-
4
-
-
0030927106
-
Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases
-
Goedert M. Cuenda A. Craxton M. Jakes R. Cohen P. Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases EMBO J 16 1997 3563-3571
-
(1997)
EMBO J.
, vol.16
, pp. 3563-3571
-
-
Goedert, M.1
Cuenda, A.2
Craxton, M.3
Jakes, R.4
Cohen, P.5
-
5
-
-
0033120590
-
Differential expression and activation of p38 mitogen-activated protein kinase alpha, beta, gamma, and delta in inflammatory cell lineages
-
Hale K.K. Trollinger D. Rihanek M. Manthey C.L. Differential expression and activation of p38 mitogen-activated protein kinase alpha, beta, gamma, and delta in inflammatory cell lineages J Immunol 162 1999 4246-4252
-
(1999)
J. Immunol.
, vol.162
, pp. 4246-4252
-
-
Hale, K.K.1
Trollinger, D.2
Rihanek, M.3
Manthey, C.L.4
-
6
-
-
0036435213
-
Transcriptional and post-transcriptional control of gene expression in inflammation
-
Kracht M. Saklatvala J. Transcriptional and post-transcriptional control of gene expression in inflammation Cytokine 20 2002 91-106
-
(2002)
Cytokine
, vol.20
, pp. 91-106
-
-
Kracht, M.1
Saklatvala, J.2
-
7
-
-
0038538477
-
Post-transcriptional regulation of gene expression by mitogen-activated protein kinase p38
-
Clark A.R. Dean J.L. Saklatvala J. Post-transcriptional regulation of gene expression by mitogen-activated protein kinase p38 FEBS Lett 546 2003 37-44
-
(2003)
FEBS Lett.
, vol.546
, pp. 37-44
-
-
Clark, A.R.1
Dean, J.L.2
Saklatvala, J.3
-
8
-
-
0036841288
-
Dexamethasone causes sustained expression of mitogen-activated protein kinase (MAPK) phosphatase 1 and phosphatase-mediated inhibition of MAPK p38
-
Lasa M. Abraham S.M. Boucheron C. Saklatvala J. Clark A.R. Dexamethasone causes sustained expression of mitogen-activated protein kinase (MAPK) phosphatase 1 and phosphatase-mediated inhibition of MAPK p38 Mol Cell Biol 22 2002 7802-7811
-
(2002)
Mol. Cell Biol.
, vol.22
, pp. 7802-7811
-
-
Lasa, M.1
Abraham, S.M.2
Boucheron, C.3
Saklatvala, J.4
Clark, A.R.5
-
9
-
-
0036193378
-
MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts
-
Wiggin G.R. Soloaga A. Foster J.M. Murray-Tait V. Cohen P. Arthur J.S. MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts Mol Cell Biol 22 2002 2871-2881
-
(2002)
Mol. Cell Biol.
, vol.22
, pp. 2871-2881
-
-
Wiggin, G.R.1
Soloaga, A.2
Foster, J.M.3
Murray-Tait, V.4
Cohen, P.5
Arthur, J.S.6
-
10
-
-
0037451357
-
Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1)
-
Vermeulen L. De Wilde G. Damme P.V. Vanden Berghe W. Haegeman G. Transcriptional activation of the NF-kappaB p65 subunit by mitogen- and stress-activated protein kinase-1 (MSK1) Embo J 22 2003 1313-1324
-
(2003)
Embo J.
, vol.22
, pp. 1313-1324
-
-
Vermeulen, L.1
De Wilde, G.2
Damme, P.V.3
Vanden Berghe, W.4
Haegeman, G.5
-
11
-
-
0038182524
-
MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14
-
Soloaga A. Thomson S. Wiggin G.R. Rampersaud N. Dyson M.H. Hazzalin C.A. Mahadevan L.C. Arthur J.S. MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14 EMBO J 22 2003 2788-2797
-
(2003)
EMBO J.
, vol.22
, pp. 2788-2797
-
-
Soloaga, A.1
Thomson, S.2
Wiggin, G.R.3
Rampersaud, N.4
Dyson, M.H.5
Hazzalin, C.A.6
Mahadevan, L.C.7
Arthur, J.S.8
-
12
-
-
0033568608
-
The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism
-
Winzen R. Kracht M. Ritter B. Wilhelm A. Chen C.Y.A. Shyu A.B. Muller M. Gaestel M. Resch K. Holtmann H. The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism EMBO J 18 1999 4969-4980
-
(1999)
EMBO J.
, vol.18
, pp. 4969-4980
-
-
Winzen, R.1
Kracht, M.2
Ritter, B.3
Wilhelm, A.4
Chen, C.Y.A.5
Shyu, A.B.6
Muller, M.7
Gaestel, M.8
Resch, K.9
Holtmann, H.10
-
13
-
-
0034077529
-
Regulation of cyclooxygenase 2 mRNA stability by the mitogen-activated protein kinase p38 signaling cascade
-
Lasa M. Mahtani K.R. Finch A. Brewer G. Saklatvala J. Clark A.R. Regulation of cyclooxygenase 2 mRNA stability by the mitogen-activated protein kinase p38 signaling cascade Mol Cell Biol 20 2000 4265-4274
-
(2000)
Mol. Cell Biol.
, vol.20
, pp. 4265-4274
-
-
Lasa, M.1
Mahtani, K.R.2
Finch, A.3
Brewer, G.4
Saklatvala, J.5
Clark, A.R.6
-
14
-
-
0033103805
-
Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU- rich elements: Implications for joint and gut-associated immunopathologies
-
Kontoyiannis D. Pasparakis M. Pizarro T.T. Cominelli F. Kollias G. Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU- rich elements: implications for joint and gut-associated immunopathologies Immunity 10 1999 387-398
-
(1999)
Immunity
, vol.10
, pp. 387-398
-
-
Kontoyiannis, D.1
Pasparakis, M.2
Pizarro, T.T.3
Cominelli, F.4
Kollias, G.5
-
15
-
-
0035162672
-
ARED: Human AU-rich element-containing mRNA database reveals an unexpectedly diverse functional repertoire of encoded proteins
-
Bakheet T. Frevel M. Williams B.R. Greer W. Khabar K.S. ARED: human AU-rich element-containing mRNA database reveals an unexpectedly diverse functional repertoire of encoded proteins Nucleic Acids Res 29 2001 246-254
-
(2001)
Nucleic Acids Res.
, vol.29
, pp. 246-254
-
-
Bakheet, T.1
Frevel, M.2
Williams, B.R.3
Greer, W.4
Khabar, K.S.5
-
16
-
-
0037223402
-
p38 mitogen-activated protein kinase-dependent and -independent signaling of mRNA stability of AU-rich element-containing transcripts
-
Frevel M.A. Bakheet T. Silva A.M. Hissong J.G. Khabar K.S. Williams B.R. p38 mitogen-activated protein kinase-dependent and -independent signaling of mRNA stability of AU-rich element-containing transcripts Mol Cell Biol 23 2003 425-436
-
(2003)
Mol. Cell Biol.
, vol.23
, pp. 425-436
-
-
Frevel, M.A.1
Bakheet, T.2
Silva, A.M.3
Hissong, J.G.4
Khabar, K.S.5
Williams, B.R.6
-
18
-
-
0036479125
-
MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels
-
Neininger A. Kontoyiannis D. Kotlyarov A. Winzen R. Eckert R. Volk H.D. Holtmann H. Kollias G. Gaestel M. MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels J Biol Chem 277 2002 3065-3068
-
(2002)
J. Biol.Chem.
, vol.277
, pp. 3065-3068
-
-
Neininger, A.1
Kontoyiannis, D.2
Kotlyarov, A.3
Winzen, R.4
Eckert, R.5
Volk, H.D.6
Holtmann, H.7
Kollias, G.8
Gaestel, M.9
-
19
-
-
0036273201
-
Distinct cellular functions of MK2
-
Kotlyarov A. Yannoni Y. Fritz S. Laass K. Telliez J.B. Pitman D. Lin L.L. Gaestel M. Distinct cellular functions of MK2 Mol Cell Biol 22 2002 4827-4835
-
(2002)
Mol. Cell Biol.
, vol.22
, pp. 4827-4835
-
-
Kotlyarov, A.1
Yannoni, Y.2
Fritz, S.3
Laass, K.4
Telliez, J.B.5
Pitman, D.6
Lin, L.L.7
Gaestel, M.8
-
20
-
-
0034644837
-
Regulation of tumour necrosis factor alpha mRNA stability by the mitogen-activated protein kinase p38 signalling cascade
-
Brook M. Sully G. Clark A.R. Saklatvala J. Regulation of tumour necrosis factor alpha mRNA stability by the mitogen-activated protein kinase p38 signalling cascade FEBS Lett 483 2000 57-61
-
(2000)
FEBS Lett.
, vol.483
, pp. 57-61
-
-
Brook, M.1
Sully, G.2
Clark, A.R.3
Saklatvala, J.4
-
21
-
-
0035794225
-
Combinations of ERK and p38 MAPK inhibitors ablate tumor necrosis factor-alpha (TNF-alpha) mRNA induction. Evidence for selective destabilization of TNF-alpha transcripts
-
Rutault K. Hazzalin C.A. Mahadevan L.C. Combinations of ERK and p38 MAPK inhibitors ablate tumor necrosis factor-alpha (TNF-alpha) mRNA induction. Evidence for selective destabilization of TNF-alpha transcripts J Biol Chem 276 2001 6666-6674
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 6666-6674
-
-
Rutault, K.1
Hazzalin, C.A.2
Mahadevan, L.C.3
-
23
-
-
0032951716
-
p38 mitogen-activated protein kinase regulates cyclooxygenase-2 mRNA stability and transcription in lipopolysaccharide-treated human monocytes
-
Dean J.L.E. Brook M. Clark A.R. Saklatvala J. p38 mitogen-activated protein kinase regulates cyclooxygenase-2 mRNA stability and transcription in lipopolysaccharide-treated human monocytes J Biol Chem 274 1999 264-269
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 264-269
-
-
Dean, J.L.E.1
Brook, M.2
Clark, A.R.3
Saklatvala, J.4
-
24
-
-
1242337338
-
Structural and functional dissection of a conseved destabilizing element of cyclo-oxygenase-2 mRNA: Eveidence against the involvement of AUF-1 [Au-rich element/poly (U)-binding/degradation factor-1], AUF-2, tristetraprolin, HuR (Hu antigen R) or FBP1 (far-upstream-sequence-element-binding protein 1)
-
Sully G. Dean J.L. Wait R. Rawlirtson L. Santalucia T. Saklatvala J. Clark A.R. Structural and functional dissection of a conseved destabilizing element of cyclo-oxygenase-2 mRNA: eveidence against the involvement of AUF-1 [Au-rich element/poly (U)-binding/degradation factor-1], AUF-2, tristetraprolin, HuR (Hu antigen R) or FBP1 (far-upstream-sequence-element-binding protein1) Biochem J 377 2004 629-639
-
(2004)
Biochem. J.
, vol.377
, pp. 629-639
-
-
Sully, G.1
Dean, J.L.2
Wait, R.3
Rawlirtson, L.4
Santalucia, T.5
Saklatvala, J.6
Clark, A.R.7
-
25
-
-
0141960214
-
p38 mitogen-activated protein kinase stabilizes mRNAs that contain cyclooxygenase-2 and tumor necrosis factor AU-rich elements by inhibiting deadenylation
-
Dean J.L. Sarsfield S.J. Tsounakou E. Saklatvala J. p38 mitogen-activated protein kinase stabilizes mRNAs that contain cyclooxygenase-2 and tumor necrosis factor AU-rich elements by inhibiting deadenylation J Biol Chem 278 2003 39470-39476
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 39470-39476
-
-
Dean, J.L.1
Sarsfield, S.J.2
Tsounakou, E.3
Saklatvala, J.4
-
26
-
-
0036438924
-
Does phosphorylation of the cap-binding protein eIF4E play a role in translation initiation?
-
Scheper G.C. Proud C.G. Does phosphorylation of the cap-binding protein eIF4E play a role in translation initiation? Eur J Biochem 269 2002 5350-5359
-
(2002)
Eur. J. Biochem.
, vol.269
, pp. 5350-5359
-
-
Scheper, G.C.1
Proud, C.G.2
-
28
-
-
0034816062
-
Mitogen-activated protein kinase p38 controls the expression and posttranslational modification of tristetraprolin, a regulator of tumor necrosis factor alpha mRNA stability
-
Mahtani K.R. Brook M. Dean J.L. Sully G. Saklatvala J. Clark A.R. Mitogen-activated protein kinase p38 controls the expression and posttranslational modification of tristetraprolin, a regulator of tumor necrosis factor alpha mRNA stability Mol Cell Biol 21 2001 6461-6469
-
(2001)
Mol. Cell Biol.
, vol.21
, pp. 6461-6469
-
-
Mahtani, K.R.1
Brook, M.2
Dean, J.L.3
Sully, G.4
Saklatvala, J.5
Clark, A.R.6
-
29
-
-
1642332899
-
MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 binding
-
Chrestensen C.A. Schroeder M.J. Shabanowitz J. Hunt D.F. Pelo J.W. Worthington M.T. Sturgill T.W. MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 binding J Biol Chem 279 2004 10176-10184
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 10176-10184
-
-
Chrestensen, C.A.1
Schroeder, M.J.2
Shabanowitz, J.3
Hunt, D.F.4
Pelo, J.W.5
Worthington, M.T.6
Sturgill, T.W.7
-
30
-
-
16044369031
-
A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency
-
Taylor G.A. Carballo E. Lee D.M. Lai W.S. Thompson M.J. Patel D.D. Schenkman D.I. Gilkeson G.S. Broxmeyer H.E. Haynes B.F. et al. A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency Immunity 4 1996 445-454
-
(1996)
Immunity
, vol.4
, pp. 445-454
-
-
Taylor, G.A.1
Carballo, E.2
Lee, D.M.3
Lai, W.S.4
Thompson, M.J.5
Patel, D.D.6
Schenkman, D.I.7
Gilkeson, G.S.8
Broxmeyer, H.E.9
Haynes, B.F.10
-
31
-
-
0033049125
-
Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA
-
Lai W.S. Carballo E. Strum J.R. Kennington E.A. Phillips R.S. Blackshear P.J. Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA Mol Cell Biol 19 1999 4311-4323
-
(1999)
Mol. Cell Biol.
, vol.19
, pp. 4311-4323
-
-
Lai, W.S.1
Carballo, E.2
Strum, J.R.3
Kennington, E.A.4
Phillips, R.S.5
Blackshear, P.J.6
-
32
-
-
0035834741
-
Decreased sensitivity of tristetraprolin-deficient cells to p38 inhibitors suggests the involvement of tristetraprolin in the p38 signaling pathway
-
Carballo E. Cao H. Lai W.S. Kennington E.A. Campbell D. Blackshear P.J. Decreased sensitivity of tristetraprolin-deficient cells to p38 inhibitors suggests the involvement of tristetraprolin in the p38 signaling pathway J Biol Chem 276 2001 42580-42587
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 42580-42587
-
-
Carballo, E.1
Cao, H.2
Lai, W.S.3
Kennington, E.A.4
Campbell, D.5
Blackshear, P.J.6
-
34
-
-
0034625369
-
Interactions of CCCH zinc finger proteins with mRNA. Binding of tristetraprolin-related zinc finger proteins to Au-rich elements and destabilization of mRNA
-
Lai W.S. Carballo E. Thorn J.M. Kennington E.A. Blackshear P.J. Interactions of CCCH zinc finger proteins with mRNA. Binding of tristetraprolin-related zinc finger proteins to Au-rich elements and destabilization of mRNA J Biol Chem 275 2000 17827-17837
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 17827-17837
-
-
Lai, W.S.1
Carballo, E.2
Thorn, J.M.3
Kennington, E.A.4
Blackshear, P.J.5
-
35
-
-
0034746363
-
The 3′ untranslated region of tumor necrosis factor alpha mRNA is a target of the mRNA-stabilizing factor HuR
-
Dean J.L. Wait R. Mahtani K.R. Sully G. Clark A.R. Saklatvala J. The 3′ untranslated region of tumor necrosis factor alpha mRNA is a target of the mRNA-stabilizing factor HuR Mol Cell Biol 21 2001 721-730
-
(2001)
Mol. Cell Biol.
, vol.21
, pp. 721-730
-
-
Dean, J.L.1
Wait, R.2
Mahtani, K.R.3
Sully, G.4
Clark, A.R.5
Saklatvala, J.6
-
36
-
-
0041375466
-
Regulation of A + U-rich element-directed mRNA turnover involving reversible phosphorylation of AUF1
-
Wilson G.M. Lu J. Sutphen K. Sun Y. Huynh Y. Brewer G. Regulation of A + U-rich element-directed mRNA turnover involving reversible phosphorylation of AUF1 J Biol Chem 278 2003 33029-33038
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 33029-33038
-
-
Wilson, G.M.1
Lu, J.2
Sutphen, K.3
Sun, Y.4
Huynh, Y.5
Brewer, G.6
-
38
-
-
0037011121
-
Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs
-
Rousseau S. Morrice N. Peggie M. Campbell D.G. Gaestel M. Cohen P. Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs EMBO J 21 2002 6505-6514
-
(2002)
EMBO J.
, vol.21
, pp. 6505-6514
-
-
Rousseau, S.1
Morrice, N.2
Peggie, M.3
Campbell, D.G.4
Gaestel, M.5
Cohen, P.6
-
39
-
-
0037436229
-
Affinity purification of ARE-binding proteins identifies polyA-binding protein 1 as a potential substrate in MK2-induced mRNA stabilization
-
Bollig F. Winzen R. Gaestel M. Kostka S. Resch K. Holtmann H. Affinity purification of ARE-binding proteins identifies polyA-binding protein 1 as a potential substrate in MK2-induced mRNA stabilization Biochem Biophys Res Commun 301 2003 665-670
-
(2003)
Biochem. Biophys. Res. Commun.
, vol.301
, pp. 665-670
-
-
Bollig, F.1
Winzen, R.2
Gaestel, M.3
Kostka, S.4
Resch, K.5
Holtmann, H.6
-
40
-
-
0034254553
-
TIA-1 is a translational silencer that selectively regulates the expression of TNF-alpha
-
Piecyk M. Wax S. Beck A.R. Kedersha N. Gupta M. Maritim B. Chen S. Gueydan C. Kruys V. Streuli M. et al. TIA-1 is a translational silencer that selectively regulates the expression of TNF-alpha EMBO J 19 2000 4154-4163
-
(2000)
EMBO J.
, vol.19
, pp. 4154-4163
-
-
Piecyk, M.1
Wax, S.2
Beck, A.R.3
Kedersha, N.4
Gupta, M.5
Maritim, B.6
Chen, S.7
Gueydan, C.8
Kruys, V.9
Streuli, M.10
-
41
-
-
0031114081
-
Actions of IL-1 are selectively controlled by p38 mitogen-activated protein kinase: Regulation of prostaglandin H synthase-2, metalloproteinases, and IL-6 at different levels
-
Ridley S.H. Sarsfield S.J. Lee J.C. Bigg H.F. Cawston T.E. Taylor D.J. DeWitt D.L. Saklatvala J. Actions of IL-1 are selectively controlled by p38 mitogen-activated protein kinase: regulation of prostaglandin H synthase-2, metalloproteinases, and IL-6 at different levels J Immunol 158 1997 3165-3173
-
(1997)
J. Immunol.
, vol.158
, pp. 3165-3173
-
-
Ridley, S.H.1
Sarsfield, S.J.2
Lee, J.C.3
Bigg, H.F.4
Cawston, T.E.5
Taylor, D.J.6
DeWitt, D.L.7
Saklatvala, J.8
-
42
-
-
0032544234
-
Regulation of interleukin-1beta-induced interleukin-6 gene expression in human fibroblast-like synoviocytes by p38 mitogen-activated protein kinase
-
Miyazawa K. Mori A. Miyata H. Akahane M. Ajisawa Y. Okudaira H. Regulation of interleukin-1beta-induced interleukin-6 gene expression in human fibroblast-like synoviocytes by p38 mitogen-activated protein kinase J Biol Chem 273 1998 24832-24838
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 24832-24838
-
-
Miyazawa, K.1
Mori, A.2
Miyata, H.3
Akahane, M.4
Ajisawa, Y.5
Okudaira, H.6
-
43
-
-
0032936517
-
The MKK6/p38 stress kinase cascade is critical for tumor necrosis factor-alpha-induced expression of monocyte-chemoattractant protein-1 in endothelial cells
-
Goebeler M. Kilian K. Gillitzer R. Kunz M. Yoshimura T. Brocker E.B. Rapp U.R. Ludwig S. The MKK6/p38 stress kinase cascade is critical for tumor necrosis factor-alpha-induced expression of monocyte-chemoattractant protein-1 in endothelial cells Blood 93 1999 857-865
-
(1999)
Blood
, vol.93
, pp. 857-865
-
-
Goebeler, M.1
Kilian, K.2
Gillitzer, R.3
Kunz, M.4
Yoshimura, T.5
Brocker, E.B.6
Rapp, U.R.7
Ludwig, S.8
-
44
-
-
0032740614
-
Extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases differentially regulate the lipopolysaccharide-mediated induction of inducible nitric oxide synthase and IL-12 in macrophages: Leishmania phosphoglycans subvert macrophage IL-12 production by targeting ERK MAP kinase
-
Feng G.J. Goodridge H.S. Harnett M.M. Wei X.Q. Nikolaev A.V. Higson A.P. Liew F.Y. Extracellular signal-related kinase (ERK) and p38 mitogen-activated protein (MAP) kinases differentially regulate the lipopolysaccharide-mediated induction of inducible nitric oxide synthase and IL-12 in macrophages: Leishmania phosphoglycans subvert macrophage IL-12 production by targeting ERK MAP kinase J Immunol 163 1999 6403-6412
-
(1999)
J. Immunol.
, vol.163
, pp. 6403-6412
-
-
Feng, G.J.1
Goodridge, H.S.2
Harnett, M.M.3
Wei, X.Q.4
Nikolaev, A.V.5
Higson, A.P.6
Liew, F.Y.7
-
45
-
-
0037200088
-
Activation of p38 alpha MAPK enhances collagenase-1 (matrix metalloproteinase (MMP)-1) and stromelysin-1 (MMP-3) expression by mRNA stabilization
-
Reunanen N. Li S.P. Ahonen M. Foschi M. Han J. Kahari V.M. Activation of p38 alpha MAPK enhances collagenase-1 (matrix metalloproteinase (MMP)-1) and stromelysin-1 (MMP-3) expression by mRNA stabilization J Biol Chem 277 2002 32360-32368
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 32360-32368
-
-
Reunanen, N.1
Li, S.P.2
Ahonen, M.3
Foschi, M.4
Han, J.5
Kahari, V.M.6
-
47
-
-
0029975919
-
Role of p38 mitogen-activated protein kinase in platelet aggregation caused by collagen or a thromboxane analogue
-
Saklatvala J. Rawlinson L. Watter R.J. Sarsfield S. Lee J.C. Morton L.F. Barnes M.J. Farndale R.W. Role of p38 mitogen-activated protein kinase in platelet aggregation caused by collagen or a thromboxane analogue J Biol Chem 271 1996 6586-6589
-
(1996)
J. Biol. Chem.
, vol.271
, pp. 6586-6589
-
-
Saklatvala, J.1
Rawlinson, L.2
Watter, R.J.3
Sarsfield, S.4
Lee, J.C.5
Morton, L.F.6
Barnes, M.J.7
Farndale, R.W.8
-
49
-
-
0031939753
-
Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family
-
Wang Y. Huang S. Sah V.P. Ross Jr. J. Brown J.H. Han J. Chien K.R. Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family J Biol Chem 273 1998 2161-2168
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 2161-2168
-
-
Wang, Y.1
Huang, S.2
Sah, V.P.3
Ross Jr., J.4
Brown, J.5
Han, J.6
Chien, K.R.7
-
51
-
-
0034613188
-
Involvement of p38 mitogen-activated protein kinase signaling pathway in osteoclastogenesis mediated by receptor activator of NF-kappa B ligand (RANKL)
-
Matsumoto M. Sudo T. Saito T. Osada H. Tsujimoto M. Involvement of p38 mitogen-activated protein kinase signaling pathway in osteoclastogenesis mediated by receptor activator of NF-kappa B ligand (RANKL) J Biol Chem 275 2000 31155-31161
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 31155-31161
-
-
Matsumoto, M.1
Sudo, T.2
Saito, T.3
Osada, H.4
Tsujimoto, M.5
-
52
-
-
0036715931
-
Pyridinylimidazole based p38 MAP kinase inhibitors
-
Jackson P.F. Bullington J.L. Pyridinylimidazole based p38 MAP kinase inhibitors Curr Top Med Chem 2 2002 1011-1020
-
(2002)
Curr. Top Med. Chem.
, vol.2
, pp. 1011-1020
-
-
Jackson, P.F.1
Bullington, J.L.2
-
53
-
-
0036719870
-
The non-diaryl heterocycle classes of p38 MAP kinase inhibitors
-
Cirillo P.F. Pargellis C. Regan J. The non-diaryl heterocycle classes of p38 MAP kinase inhibitors Curr Top Med Chem 2 2002 1021-1035
-
(2002)
Curr. Top Med. Chem.
, vol.2
, pp. 1021-1035
-
-
Cirillo, P.F.1
Pargellis, C.2
Regan, J.3
-
54
-
-
18344395134
-
Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site
-
Pargellis C. Tong L. Churchill L. Cirillo P.F. Gilmore T. Graham A.G. Grob P.M. Hickey E.R. Moss N. Pav S. et al. Inhibition of p38 MAP kinase by utilizing a novel allosteric binding site Nat Struct Biol 9 2002 268-272
-
(2002)
Nat. Struct. Biol.
, vol.9
, pp. 268-272
-
-
Pargellis, C.1
Tong, L.2
Churchill, L.3
Cirillo, P.F.4
Gilmore, T.5
Graham, A.G.6
Grob, P.M.7
Hickey, E.R.8
Moss, N.9
Pav, S.10
-
55
-
-
0038179379
-
Inhibitors of p38 mitogen-activated protein kinase for the treatment of rheumatoid arthritis
-
Pargellis C. Regan J. Inhibitors of p38 mitogen-activated protein kinase for the treatment of rheumatoid arthritis Curr Opin Investig Drugs 4 2003 566-571
-
(2003)
Curr. Opin. Investig. Drugs
, vol.4
, pp. 566-571
-
-
Pargellis, C.1
Regan, J.2
|