-
1
-
-
0032547272
-
Induction of inhibitory Smad6 and Smad7 mRNA by TGF-β family members
-
Afrakhte, M., Moren, A., Jossan, S., Itoh, S., Sampath, K., Westermark, B., Heldin, C.H., Heldin, N.E., and ten Dijke, P. 1998. Induction of inhibitory Smad6 and Smad7 mRNA by TGF-β family members. Biochem. Biophys. Res. Commun. 249: 505-511.
-
(1998)
Biochem. Biophys. Res. Commun.
, vol.249
, pp. 505-511
-
-
Afrakhte, M.1
Moren, A.2
Jossan, S.3
Itoh, S.4
Sampath, K.5
Westermark, B.6
Heldin, C.H.7
Heldin, N.E.A.8
Ten Dijke, P.9
-
2
-
-
0033521032
-
c-Ski acts as a transcriptional co-repressor in transforming growth factor-β signaling through interaction with Smads
-
Akiyoshi, S., Inoue, H., Hanai, J., Kusanagi, K., Nemoto, N., Miyazono, K., and Kawabata, M. 1999. c-Ski acts as a transcriptional co-repressor in transforming growth factor-β signaling through interaction with Smads. J. Biol. Chem. 274: 35269-35277.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 35269-35277
-
-
Akiyoshi, S.1
Inoue, H.2
Hanai, J.3
Kusanagi, K.4
Nemoto, N.5
Miyazono, K.6
Kawabata, M.7
-
3
-
-
0035341209
-
TGF-β-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation
-
Alliston, T., Choy, L., Ducy, P., Karsenty, G., and Derynck, R. 2001. TGF-β-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation. EMBO J. 20: 2254-2272.
-
(2001)
EMBO J.
, vol.20
, pp. 2254-2272
-
-
Alliston, T.1
Choy, L.2
Ducy, P.3
Karsenty, G.4
Derynck, R.5
-
4
-
-
0037204990
-
Signal transduction by the TGF-β superfamily
-
Attisano, L. and Wrana, J.L. 2002. Signal transduction by the TGF-β superfamily. Science 296: 1646-1647.
-
(2002)
Science
, vol.296
, pp. 1646-1647
-
-
Attisano, L.1
Wrana, J.L.2
-
5
-
-
2942650916
-
In vivo convergence of BMP and MAPK signaling pathways: Impact of differential Smad1 phosphorylation on development and homeostasis
-
Aubin, J., Davy, A., and Soriano, P. 2004. In vivo convergence of BMP and MAPK signaling pathways: Impact of differential Smad1 phosphorylation on development and homeostasis. Genes & Dev. 18: 1482-1494.
-
(2004)
Genes & Dev.
, vol.18
, pp. 1482-1494
-
-
Aubin, J.1
Davy, A.2
Soriano, P.3
-
6
-
-
0034708801
-
Smad6 as a transcriptional corepressor
-
Bai, S., Shi, X., Yang, X., and Cao, X. 2000. Smad6 as a transcriptional corepressor. J. Biol. Chem. 275: 8267-8270.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 8267-8270
-
-
Bai, S.1
Shi, X.2
Yang, X.3
Cao, X.4
-
7
-
-
0036119191
-
SMIF, a Smad4-interacting protein that functions as a co-activator in TGFβ signalling
-
Bai, R.Y., Koester, C., Ouyang, T., Hahn, S.A., Hammerschmidt, M., Peschel, C., and Duyster, J. 2002. SMIF, a Smad4-interacting protein that functions as a co-activator in TGFβ signalling. Nat. Cell Biol. 4: 181-190.
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 181-190
-
-
Bai, R.Y.1
Koester, C.2
Ouyang, T.3
Hahn, S.A.4
Hammerschmidt, M.5
Peschel, C.6
Duyster, J.7
-
8
-
-
4444223733
-
Itch E3 ligase-mediated regulation of TGF-β signaling by modulating smad2 phosphorylation
-
Bai, Y., Yang, C., Hu, K., Elly, C., and Liu, Y.C. 2004. Itch E3 ligase-mediated regulation of TGF-β signaling by modulating smad2 phosphorylation. Mol. Cell 15: 825-831.
-
(2004)
Mol. Cell
, vol.15
, pp. 825-831
-
-
Bai, Y.1
Yang, C.2
Hu, K.3
Elly, C.4
Liu, Y.C.5
-
9
-
-
20044378296
-
Global gene expression profiling and cluster analysis in Xenopus laevis
-
Baldessari, D., Shin, Y., Krebs, O., Konig, R., Koide, T., Vinayagam, A., Fenger, U., Mochii, M., Terasaka, C., Kitayama, A., et al. 2005. Global gene expression profiling and cluster analysis in Xenopus laevis. Mech. Dev. 122: 441-475.
-
(2005)
Mech. Dev.
, vol.122
, pp. 441-475
-
-
Baldessari, D.1
Shin, Y.2
Krebs, O.3
Konig, R.4
Koide, T.5
Vinayagam, A.6
Fenger, U.7
Mochii, M.8
Terasaka, C.9
Kitayama, A.10
-
10
-
-
0030480969
-
The CBP co-activator is a histone acetyltransferase
-
Bannister, A.J. and Kouzarides, T. 1996. The CBP co-activator is a histone acetyltransferase. Nature 384: 641-643.
-
(1996)
Nature
, vol.384
, pp. 641-643
-
-
Bannister, A.J.1
Kouzarides, T.2
-
11
-
-
0034616910
-
Structural basis for the interaction between FxFG nucleoporin repeats and importin-β in nuclear trafficking
-
Bayliss, R., Littlewood, T., and Stewart, M. 2000. Structural basis for the interaction between FxFG nucleoporin repeats and importin-β in nuclear trafficking. Cell 102: 99-108.
-
(2000)
Cell
, vol.102
, pp. 99-108
-
-
Bayliss, R.1
Littlewood, T.2
Stewart, M.3
-
12
-
-
0043192745
-
GATA- and Smad1-dependent enhancers in the Smad7 gene differentially interpret bone morphogenetic protein concentrations
-
Benchabane, H. and Wrana, J.L. 2003. GATA- and Smad1-dependent enhancers in the Smad7 gene differentially interpret bone morphogenetic protein concentrations. Mol. Cell. Biol. 23: 6646-6661.
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 6646-6661
-
-
Benchabane, H.1
Wrana, J.L.2
-
13
-
-
0030799236
-
Mice lacking the ski proto-oncogene have defects in neurulation, craniofacial, patterning, and skeletal muscle development
-
Berk, M., Desai, S.Y., Heyman, H.C., and Colmenares, C. 1997. Mice lacking the ski proto-oncogene have defects in neurulation, craniofacial, patterning, and skeletal muscle development. Genes & Dev. 11: 2029-2039.
-
(1997)
Genes & Dev.
, vol.11
, pp. 2029-2039
-
-
Berk, M.1
Desai, S.Y.2
Heyman, H.C.3
Colmenares, C.4
-
14
-
-
0032529532
-
Smad7 inhibits mesoderm formation and promotes neural cell fate in Xenopus embryos
-
Bhushan, A., Chen, Y., and Vale, W. 1998. Smad7 inhibits mesoderm formation and promotes neural cell fate in Xenopus embryos. Dev. Biol. 200: 260-268.
-
(1998)
Dev. Biol.
, vol.200
, pp. 260-268
-
-
Bhushan, A.1
Chen, Y.2
Vale, W.3
-
15
-
-
0034650266
-
A mechanism of suppression of TGF-β/SMAD signaling by NF-κB/RelA
-
Bitzer, M., von Gersdorff, G., Liang, D., Dominguez-Rosales, A., Beg, A.A., Rojkind, M., and Bottinger, E.P. 2000. A mechanism of suppression of TGF-β/SMAD signaling by NF-κB/RelA. Genes & Dev. 14: 187-197.
-
(2000)
Genes & Dev.
, vol.14
, pp. 187-197
-
-
Bitzer, M.1
Von Gersdorff, G.2
Liang, D.3
Dominguez-Rosales, A.4
Beg, A.A.5
Rojkind, M.6
Bottinger, E.P.7
-
16
-
-
0034976149
-
TGF-β induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation
-
Bonni, S., Wang, H.R., Causing, C.G., Kavsak, P., Stroschein, S.L., Luo, K., and Wrana, J.L. 2001. TGF-β induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation. Nat. Cell Biol. 3: 587-595.
-
(2001)
Nat. Cell Biol.
, vol.3
, pp. 587-595
-
-
Bonni, S.1
Wang, H.R.2
Causing, C.G.3
Kavsak, P.4
Stroschein, S.L.5
Luo, K.6
Wrana, J.L.7
-
17
-
-
0036333146
-
A changing morphogen gradient is interpreted by continuous transduction flow
-
Bourillot, P.Y., Garrett, N., and Gurdon, J.B. 2002. A changing morphogen gradient is interpreted by continuous transduction flow. Development 129: 2167-2180.
-
(2002)
Development
, vol.129
, pp. 2167-2180
-
-
Bourillot, P.Y.1
Garrett, N.2
Gurdon, J.B.3
-
18
-
-
0034666152
-
Efficient TGF-β induction of the Smad7 gene requires cooperation between AP-1, Sp1, and Smad proteins on the mouse Smad7 promoter
-
Brodin, G., Ahgren, A., ten Dijke, P., Heldin, C.H., and Heuchel, R. 2000. Efficient TGF-β induction of the Smad7 gene requires cooperation between AP-1, Sp1, and Smad proteins on the mouse Smad7 promoter. J. Biol. Chem. 275: 29023-29030.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 29023-29030
-
-
Brodin, G.1
Ahgren, A.2
Ten Dijke, P.3
Heldin, C.H.4
Heuchel, R.5
-
19
-
-
1642402120
-
The cardiac determination factor, Nkx2-5, is activated by mutual cofactors GATA-4 and Smad1/4 via a novel upstream enhancer
-
Brown III, C.O., Chi, X., Garcia-Gras, E., Shirai, M., Feng, X.H., and Schwartz, R.J. 2004. The cardiac determination factor, Nkx2-5, is activated by mutual cofactors GATA-4 and Smad1/4 via a novel upstream enhancer. J. Biol. Chem. 279: 10659-10669.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 10659-10669
-
-
Brown III, C.O.1
Chi, X.2
Garcia-Gras, E.3
Shirai, M.4
Feng, X.H.5
Schwartz, R.J.6
-
20
-
-
0032900499
-
The Drosophila activin receptor baboon signals through dSmad2 and controls cell proliferation but not patterning during larval development
-
Brummel, T., Abdollah, S., Haerry, T.E., Shimell, M.J., Merriam, J., Raftery, L., Wrana, J.L., and O'Connor, M.B. 1999. The Drosophila activin receptor baboon signals through dSmad2 and controls cell proliferation but not patterning during larval development. Genes & Dev. 13: 98-111.
-
(1999)
Genes & Dev.
, vol.13
, pp. 98-111
-
-
Brummel, T.1
Abdollah, S.2
Haerry, T.E.3
Shimell, M.J.4
Merriam, J.5
Raftery, L.6
Wrana, J.L.7
O'Connor, M.B.8
-
21
-
-
0033582929
-
Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
-
Brunet, A., Bonni, A., Zigmond, M.J., Lin, M.Z., Juo, P., Hu, L.S., Anderson, M.J., Arden, K.C., Blenis, J., and Greenberg, M.E. 1999. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96: 857-868.
-
(1999)
Cell
, vol.96
, pp. 857-868
-
-
Brunet, A.1
Bonni, A.2
Zigmond, M.J.3
Lin, M.Z.4
Juo, P.5
Hu, L.S.6
Anderson, M.J.7
Arden, K.C.8
Blenis, J.9
Greenberg, M.E.10
-
22
-
-
0032101098
-
Xenopus Smad7 inhibits both the activin and BMP pathways and acts as a neural inducer
-
Casellas, R. and Brivanlou, A.H. 1998. Xenopus Smad7 inhibits both the activin and BMP pathways and acts as a neural inducer. Dev. Biol. 198: 1-12.
-
(1998)
Dev. Biol.
, vol.198
, pp. 1-12
-
-
Casellas, R.1
Brivanlou, A.H.2
-
23
-
-
0035123060
-
The L3 loop and C-terminal phosphorylation jointly define Smad protein trimerization
-
Chacko, B.M., Qin, B., Correia, J.J., Lam, S.S., de Caestecker, M.P., and Lin, K. 2001. The L3 loop and C-terminal phosphorylation jointly define Smad protein trimerization. Nat. Struct. Biol. 8: 248-253.
-
(2001)
Nat. Struct. Biol.
, vol.8
, pp. 248-253
-
-
Chacko, B.M.1
Qin, B.2
Correia, J.J.3
Lam, S.S.4
De Caestecker, M.P.5
Lin, K.6
-
24
-
-
4444250157
-
Structural basis of heteromeric smad protein assembly in TGF-β signaling
-
Chacko, B.M., Qin, B.Y., Tiwari, A., Shi, G., Lam, S., Hayward, L.J., De Caestecker, M., and Lin, K. 2004. Structural basis of heteromeric smad protein assembly in TGF-β signaling. Mol. Cell 15: 813-823.
-
(2004)
Mol. Cell
, vol.15
, pp. 813-823
-
-
Chacko, B.M.1
Qin, B.Y.2
Tiwari, A.3
Shi, G.4
Lam, S.5
Hayward, L.J.6
De Caestecker, M.7
Lin, K.8
-
25
-
-
0038820062
-
Features of a Smad3 MH1-DNA complex. Roles of water and zinc in DNA binding
-
Chai, J., Wu, J.W., Yan, N., Massagué, J., Pavletich, N.P., and Shi, Y. 2003. Features of a Smad3 MH1-DNA complex. Roles of water and zinc in DNA binding. J. Biol. Chem. 278: 20327-20331.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 20327-20331
-
-
Chai, J.1
Wu, J.W.2
Yan, N.3
Massagué, J.4
Pavletich, N.P.5
Shi, Y.6
-
26
-
-
15444380557
-
Daxx mediates the small ubiquitin-like modifier-dependent transcriptional repression of Smad4
-
Chang, C.C., Lin, D.Y., Fang, H.I., Chen, R.H., and Shih, H.M. 2005. Daxx mediates the small ubiquitin-like modifier-dependent transcriptional repression of Smad4. J. Biol. Chem. 280: 10164-10173.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 10164-10173
-
-
Chang, C.C.1
Lin, D.Y.2
Fang, H.I.3
Chen, R.H.4
Shih, H.M.5
-
27
-
-
0029802485
-
A transcriptional partner for MAD proteins in TGF-β signalling
-
Chen, X., Rubock, M.J., and Whitman, M. 1996. A transcriptional partner for MAD proteins in TGF-β signalling. Nature 383: 691-696.
-
(1996)
Nature
, vol.383
, pp. 691-696
-
-
Chen, X.1
Rubock, M.J.2
Whitman, M.3
-
28
-
-
0030961168
-
Smad4 and FAST-1 in the assembly of activin-responsive factor
-
Chen, X., Weisberg, E., Fridmacher, V., Watanabe, M., Naco, G., and Whitman, M. 1997. Smad4 and FAST-1 in the assembly of activin-responsive factor. Nature 389: 85-89.
-
(1997)
Nature
, vol.389
, pp. 85-89
-
-
Chen, X.1
Weisberg, E.2
Fridmacher, V.3
Watanabe, M.4
Naco, G.5
Whitman, M.6
-
29
-
-
0030926004
-
Mechanism of TGFβ receptor inhibition by FKBP12
-
Chen, Y.G., Liu, F., and Massagué, J. 1997. Mechanism of TGFβ receptor inhibition by FKBP12. EMBO J. 16: 3866-3876.
-
(1997)
EMBO J.
, vol.16
, pp. 3866-3876
-
-
Chen, Y.G.1
Liu, F.2
Massagué, J.3
-
30
-
-
0035970035
-
Defective repression of c-myc in breast cancer cells: A loss at the core of the transforming growth factor β growth arrest program
-
Chen, C.R., Kang, Y., and Massagué, J. 2001. Defective repression of c-myc in breast cancer cells: A loss at the core of the transforming growth factor β growth arrest program. Proc. Natl. Acad. Sci. 98: 992-1009.
-
(2001)
Proc. Natl. Acad. Sci.
, vol.98
, pp. 992-1009
-
-
Chen, C.R.1
Kang, Y.2
Massagué, J.3
-
31
-
-
0037067653
-
E2F4/5 and p107 as Smad cofactors linking the TGFβ receptor to c-myc repression
-
Chen, C.R., Kang, Y., Siegel, P.M., and Massagué, J. 2002. E2F4/5 and p107 as Smad cofactors linking the TGFβ receptor to c-myc repression. Cell 110: 19-32.
-
(2002)
Cell
, vol.110
, pp. 19-32
-
-
Chen, C.R.1
Kang, Y.2
Siegel, P.M.3
Massagué, J.4
-
32
-
-
0037059735
-
The androgen receptor represses transforming growth factor-β signaling through interaction with Smad3
-
Chipuk, J.E., Cornelius, S.C., Pultz, N.J., Jorgensen, J.S., Bonham, M.J., Kim, S.J., and Danielpour, D. 2002. The androgen receptor represses transforming growth factor-β signaling through interaction with Smad3. J. Biol. Chem. 277: 1240-1248.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 1240-1248
-
-
Chipuk, J.E.1
Cornelius, S.C.2
Pultz, N.J.3
Jorgensen, J.S.4
Bonham, M.J.5
Kim, S.J.6
Danielpour, D.7
-
33
-
-
4444249320
-
Differential requirements for Smad4 in TGFβ-dependent patterning of the early mouse embryo
-
Chu, G.C., Dunn, N.R., Anderson, D.C., Oxburgh, L., and Robertson, E.J. 2004. Differential requirements for Smad4 in TGFβ-dependent patterning of the early mouse embryo. Development 131: 3501-3512.
-
(2004)
Development
, vol.131
, pp. 3501-3512
-
-
Chu, G.C.1
Dunn, N.R.2
Anderson, D.C.3
Oxburgh, L.4
Robertson, E.J.5
-
34
-
-
0025948485
-
Activation of the c-ski oncogene by overexpression
-
Colmenares, C., Sutrave, P., Hughes, S.H., and Stavnezer, E. 1991. Activation of the c-ski oncogene by overexpression. J. Virol. 65: 4929-4935.
-
(1991)
J. Virol.
, vol.65
, pp. 4929-4935
-
-
Colmenares, C.1
Sutrave, P.2
Hughes, S.H.3
Stavnezer, E.4
-
35
-
-
0036334452
-
Loss of the SKI proto-oncogene in individuals affected with 1p36 deletion syndrome is predicted by strain-dependent defects in Ski-/- mice
-
Colmenares, C., Heilstedt, H.A., Shaffer, L.G., Schwartz, S., Berk, M., Murray, J.C., and Stavnezer, E. 2002. Loss of the SKI proto-oncogene in individuals affected with 1p36 deletion syndrome is predicted by strain-dependent defects in Ski-/- mice. Nat. Genet. 30: 106-109.
-
(2002)
Nat. Genet.
, vol.30
, pp. 106-109
-
-
Colmenares, C.1
Heilstedt, H.A.2
Shaffer, L.G.3
Schwartz, S.4
Berk, M.5
Murray, J.C.6
Stavnezer, E.7
-
36
-
-
0038274163
-
Links between tumor suppressors: p53 is required for TGF-β gene responses by cooperating with Smads
-
Cordenonsi, M., Dupont, S., Maretto, S., Insinga, A., Imbriano, C., and Piccolo, S. 2003. Links between tumor suppressors: p53 is required for TGF-β gene responses by cooperating with Smads. Cell 113: 301-314.
-
(2003)
Cell
, vol.113
, pp. 301-314
-
-
Cordenonsi, M.1
Dupont, S.2
Maretto, S.3
Insinga, A.4
Imbriano, C.5
Piccolo, S.6
-
37
-
-
0033233271
-
Genetic approaches to TGF signaling pathways
-
Das, P., Maduzia, L.L., and Padgett, R.W. 1999. Genetic approaches to TGF signaling pathways. Cytokine Growth Factor Rev. 10: 179-186.
-
(1999)
Cytokine Growth Factor Rev.
, vol.10
, pp. 179-186
-
-
Das, P.1
Maduzia, L.L.2
Padgett, R.W.3
-
38
-
-
0032567487
-
Identification of STRAP, a novel WD domain protein in transforming growth factor-β signaling
-
Datta, P.K., Chytil, A., Gorska, A.E., and Moses, H.L. 1998. Identification of STRAP, a novel WD domain protein in transforming growth factor-β signaling. J. Biol. Chem. 273: 34671-34674.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 34671-34674
-
-
Datta, P.K.1
Chytil, A.2
Gorska, A.E.3
Moses, H.L.4
-
39
-
-
0034695590
-
The Smad4 activation domain (SAD) is a proline-rich, p300-dependent transcriptional activation domain
-
de Caestecker, M.P., Yahata, T., Wang, D., Parks, W.T., Huang, S., Hill, C.S., Shioda, T., Roberts, A.B., and Lechleider, R.J. 2000. The Smad4 activation domain (SAD) is a proline-rich, p300-dependent transcriptional activation domain. J. Biol. Chem. 275: 2115-2122.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 2115-2122
-
-
De Caestecker, M.P.1
Yahata, T.2
Wang, D.3
Parks, W.T.4
Huang, S.5
Hill, C.S.6
Shioda, T.7
Roberts, A.B.8
Lechleider, R.J.9
-
40
-
-
0034612231
-
Transforming growth factor β-inducible independent binding of SMAD to the Smad7 promoter
-
Denissova, N.G., Pouponnot, C., Long, J., He, D., and Liu, F. 2000. Transforming growth factor β-inducible independent binding of SMAD to the Smad7 promoter. Proc. Natl. Acad. Sci. 97: 6397-6402.
-
(2000)
Proc. Natl. Acad. Sci.
, vol.97
, pp. 6397-6402
-
-
Denissova, N.G.1
Pouponnot, C.2
Long, J.3
He, D.4
Liu, F.5
-
41
-
-
0142104985
-
Smad-dependent and Smad-independent pathways in TGF-β family signalling
-
Derynck, R. and Zhang, Y.E. 2003. Smad-dependent and Smad-independent pathways in TGF-β family signalling. Nature 425: 577-584.
-
(2003)
Nature
, vol.425
, pp. 577-584
-
-
Derynck, R.1
Zhang, Y.E.2
-
42
-
-
0034785348
-
TGF-β signaling in tumor suppression and cancer progression
-
Derynck, R., Akhurst, R.J., and Balmain, A. 2001. TGF-β signaling in tumor suppression and cancer progression. Nat. Genet. 29: 117-129.
-
(2001)
Nat. Genet.
, vol.29
, pp. 117-129
-
-
Derynck, R.1
Akhurst, R.J.2
Balmain, A.3
-
43
-
-
0032135131
-
SUMO-1 modification of IκBα inhibits NF-κB activation
-
Desterro, J.M., Rodriguez, M.S., and Hay, R.T. 1998. SUMO-1 modification of IκBα inhibits NF-κB activation. Mol. Cell 2: 233-239.
-
(1998)
Mol. Cell
, vol.2
, pp. 233-239
-
-
Desterro, J.M.1
Rodriguez, M.S.2
Hay, R.T.3
-
44
-
-
0037598870
-
Distinct endocytic pathways regulate TGF-β receptor signalling and turnover
-
Di Guglielmo, G.M., Le Roy, C., Goodfellow, A.F., and Wrana, J.L. 2003. Distinct endocytic pathways regulate TGF-β receptor signalling and turnover. Nat. Cell Biol. 5: 410-421.
-
(2003)
Nat. Cell Biol.
, vol.5
, pp. 410-421
-
-
Di Guglielmo, G.M.1
Le Roy, C.2
Goodfellow, A.F.3
Wrana, J.L.4
-
45
-
-
11844271440
-
Mice exclusively expressing the short isoform of Smad2 develop normally and are viable and fertile
-
Dunn, N.R., Koonce, C.H., Anderson, D.C., Islam, A., Bikoff, E.K., and Robertson, E.J. 2005. Mice exclusively expressing the short isoform of Smad2 develop normally and are viable and fertile. Genes & Dev. 19: 152-163.
-
(2005)
Genes & Dev.
, vol.19
, pp. 152-163
-
-
Dunn, N.R.1
Koonce, C.H.2
Anderson, D.C.3
Islam, A.4
Bikoff, E.K.5
Robertson, E.J.6
-
46
-
-
17044365440
-
Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase
-
Dupont, S., Zacchigna, L., Cordenonsi, M., Soligo, S., Adorno, M., Rugge, M., and Piccolo, S. 2005. Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase. Cell 121: 87-99.
-
(2005)
Cell
, vol.121
, pp. 87-99
-
-
Dupont, S.1
Zacchigna, L.2
Cordenonsi, M.3
Soligo, S.4
Adorno, M.5
Rugge, M.6
Piccolo, S.7
-
47
-
-
0032524323
-
The interpretation of position in a morphogen gradient as revealed by occupancy of activin receptors
-
Dyson, S. and Gurdon, J.B. 1998. The interpretation of position in a morphogen gradient as revealed by occupancy of activin receptors. Cell 93: 557-568.
-
(1998)
Cell
, vol.93
, pp. 557-568
-
-
Dyson, S.1
Gurdon, J.B.2
-
48
-
-
0035848835
-
Induction of the mammalian node requires Arkadia function in the extraembryonic lineages
-
Episkopou, V., Arkell, R., Timmons, P.M., Walsh, J.J., Andrew, R.L., and Swan, D. 2001. Induction of the mammalian node requires Arkadia function in the extraembryonic lineages. Nature 410: 825-830.
-
(2001)
Nature
, vol.410
, pp. 825-830
-
-
Episkopou, V.1
Arkell, R.2
Timmons, P.M.3
Walsh, J.J.4
Andrew, R.L.5
Swan, D.6
-
49
-
-
0141995069
-
The nuclear pore complex: Nucleocytoplasmic transport and beyond
-
Fahrenkrog, B. and Aebi, U. 2003. The nuclear pore complex: Nucleocytoplasmic transport and beyond. Nat. Rev. Mol. Cell Biol. 4: 757-766.
-
(2003)
Nat. Rev. Mol. Cell Biol.
, vol.4
, pp. 757-766
-
-
Fahrenkrog, B.1
Aebi, U.2
-
50
-
-
0042738094
-
TLP, a novel modulator of TGF-β signaling, has opposite effects on Smad2- and Smad3-dependent signaling
-
Felici, A., Wurthner, J.U., Parks, W.T., Giam, L.R., Reiss, M., Karpova, T.S., McNally, J.G., and Roberts, A.B. 2003. TLP, a novel modulator of TGF-β signaling, has opposite effects on Smad2- and Smad3-dependent signaling. EMBO J. 22: 4465-4477.
-
(2003)
EMBO J.
, vol.22
, pp. 4465-4477
-
-
Felici, A.1
Wurthner, J.U.2
Parks, W.T.3
Giam, L.R.4
Reiss, M.5
Karpova, T.S.6
McNally, J.G.7
Roberts, A.B.8
-
51
-
-
0032528236
-
The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for Smad3 in TGF-β-induced transcriptional activation
-
Feng, X.-H., Zhang, Y., Wu, R.-Y., and Derynck, R. 1998. The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for Smad3 in TGF-β-induced transcriptional activation. Genes & Dev. 12: 2153-2163.
-
(1998)
Genes & Dev.
, vol.12
, pp. 2153-2163
-
-
Feng, X.-H.1
Zhang, Y.2
Wu, R.-Y.3
Derynck, R.4
-
52
-
-
0034596993
-
Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-β
-
Feng, X.H., Lin, X., and Derynck, R. 2000. Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-β. EMBO J. 19: 5178-5193.
-
(2000)
EMBO J.
, vol.19
, pp. 5178-5193
-
-
Feng, X.H.1
Lin, X.2
Derynck, R.3
-
53
-
-
0141656297
-
Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1
-
Foletta, V.C., Lim, M.A., Soosairajah, J., Kelly, A.P., Stanley, E.G., Shannon, M., He, W., Das, S., Massagué, J., and Bernard, O. 2003. Direct signaling by the BMP type II receptor via the cytoskeletal regulator LIMK1. J. Cell Biol. 162: 1089-1099.
-
(2003)
J. Cell Biol.
, vol.162
, pp. 1089-1099
-
-
Foletta, V.C.1
Lim, M.A.2
Soosairajah, J.3
Kelly, A.P.4
Stanley, E.G.5
Shannon, M.6
He, W.7
Das, S.8
Massagué, J.9
Bernard, O.10
-
54
-
-
0030924190
-
CRM1 is an export receptor for leucine-rich nuclear export signals
-
Fornerod, M., Ohno, M., Yoshida, M., and Mattaj, I.Q. 1997. CRM1 is an export receptor for leucine-rich nuclear export signals. Cell 90: 1051-1060.
-
(1997)
Cell
, vol.90
, pp. 1051-1060
-
-
Fornerod, M.1
Ohno, M.2
Yoshida, M.3
Mattaj, I.Q.4
-
55
-
-
1542314236
-
Transforming growth factor β-mediated transcriptional repression of c-myc is dependent on direct binding of Smad3 to a novel repressive Smad binding element
-
Frederick, J.P., Liberati, N.R., Waddell, D.S., Shi, Y., and Wang, X.F. 2004. Transforming growth factor β-mediated transcriptional repression of c-myc is dependent on direct binding of Smad3 to a novel repressive Smad binding element. Mol. Cell. Biol. 24: 2546-2559.
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 2546-2559
-
-
Frederick, J.P.1
Liberati, N.R.2
Waddell, D.S.3
Shi, Y.4
Wang, X.F.5
-
56
-
-
0034767430
-
Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins
-
Fukuchi, M., Imamura, T., Chiba, T., Ebisawa, T., Kawabata, M., Tanaka, K., and Miyazono, K. 2001. Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins. Mol. Biol. Cell 12: 1431-1443.
-
(2001)
Mol. Biol. Cell
, vol.12
, pp. 1431-1443
-
-
Fukuchi, M.1
Imamura, T.2
Chiba, T.3
Ebisawa, T.4
Kawabata, M.5
Tanaka, K.6
Miyazono, K.7
-
57
-
-
0034947962
-
Axin facilitates Smad3 activation in the transforming growth factor β signaling pathway
-
Furuhashi, M., Yagi, K., Yamamoto, H., Furukawa, Y., Shimada, S., Nakamura, Y., Kikuchi, A., Miyazono, K., and Kato, M. 2001. Axin facilitates Smad3 activation in the transforming growth factor β signaling pathway. Mol. Cell. Biol. 21: 5132-5141.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 5132-5141
-
-
Furuhashi, M.1
Yagi, K.2
Yamamoto, H.3
Furukawa, Y.4
Shimada, S.5
Nakamura, Y.6
Kikuchi, A.7
Miyazono, K.8
Kato, M.9
-
58
-
-
17444453852
-
A role for smad6 in development and homeostasis of the cardiovascular system
-
Galvin, K.M., Donovan, M.J., Lynch, C.A., Meyer, R.I., Paul, R.J., Lorenz, J.N., Fairchild-Huntress, V., Dixon, K.L., Dunmore, J.H., Gimbrone Jr., M.A., et al. 2000. A role for smad6 in development and homeostasis of the cardiovascular system. Nat. Genet. 24: 171-174.
-
(2000)
Nat. Genet.
, vol.24
, pp. 171-174
-
-
Galvin, K.M.1
Donovan, M.J.2
Lynch, C.A.3
Meyer, R.I.4
Paul, R.J.5
Lorenz, J.N.6
Fairchild-Huntress, V.7
Dixon, K.L.8
Dunmore, J.H.9
Gimbrone Jr., M.A.10
-
59
-
-
0031727693
-
Gene expression screening in Xenopus identifies molecular pathways, predicts gene function and provides a global view of embryonic patterning
-
Gawantka, V., Pollet, N., Delius, H., Vingron, M., Pfister, R., Nitsch, R., Blumenstock, C., and Niehrs, C. 1998. Gene expression screening in Xenopus identifies molecular pathways, predicts gene function and provides a global view of embryonic patterning. Mech. Dev. 77: 95-141.
-
(1998)
Mech. Dev.
, vol.77
, pp. 95-141
-
-
Gawantka, V.1
Pollet, N.2
Delius, H.3
Vingron, M.4
Pfister, R.5
Nitsch, R.6
Blumenstock, C.7
Niehrs, C.8
-
60
-
-
0034007925
-
Homeodomain and winged-helix transcription factors recruit activated Smads to distinct promoter elements via a common Smad interaction motif
-
Germain, S., Howell, M., Esslemont, G.M., and Hill, C.S. 2000. Homeodomain and winged-helix transcription factors recruit activated Smads to distinct promoter elements via a common Smad interaction motif. Genes & Dev. 14: 435-451.
-
(2000)
Genes & Dev.
, vol.14
, pp. 435-451
-
-
Germain, S.1
Howell, M.2
Esslemont, G.M.3
Hill, C.S.4
-
61
-
-
0033279841
-
Transport between the cell nucleus and the cytoplasm
-
Gorlich, D. and Kutay, U. 1999. Transport between the cell nucleus and the cytoplasm. Annu. Rev. Cell Dev. Biol. 15: 607-660.
-
(1999)
Annu. Rev. Cell Dev. Biol.
, vol.15
, pp. 607-660
-
-
Gorlich, D.1
Kutay, U.2
-
62
-
-
0024518943
-
Loss of competence in amphibian induction can take place in single nondividing cells
-
Grainger, R.M. and Gurdon, J.B. 1989. Loss of competence in amphibian induction can take place in single nondividing cells. Proc. Natl. Acad. Sci. 86: 1900-1904.
-
(1989)
Proc. Natl. Acad. Sci.
, vol.86
, pp. 1900-1904
-
-
Grainger, R.M.1
Gurdon, J.B.2
-
63
-
-
0036301992
-
Nuclear exclusion of Smad2 is a mechanism leading to loss of competence
-
Grimm, O.H. and Gurdon, J.B. 2002. Nuclear exclusion of Smad2 is a mechanism leading to loss of competence. Nat. Cell Biol. 4: 519-522.
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 519-522
-
-
Grimm, O.H.1
Gurdon, J.B.2
-
64
-
-
16744368142
-
Mutations in TGIF cause holoprosencephaly and link NODAL signalling to human neural axis determination
-
Gripp, K.W., Wotton, D., Edwards, M.C., Roessler, E., Ades, L., Meinecke, P., Richieri-Costa, A., Zackai, E.H., Massagué, J., Muenke, M., et al. 2000. Mutations in TGIF cause holoprosencephaly and link NODAL signalling to human neural axis determination. Nat. Genet. 25: 205-208.
-
(2000)
Nat. Genet.
, vol.25
, pp. 205-208
-
-
Gripp, K.W.1
Wotton, D.2
Edwards, M.C.3
Roessler, E.4
Ades, L.5
Meinecke, P.6
Richieri-Costa, A.7
Zackai, E.H.8
Massagué, J.9
Muenke, M.10
-
65
-
-
0036753547
-
Control of Smad7 stability by competition between acetylation and ubiquitination
-
Gronroos, E., Hellman, U., Heldin, C.H., and Ericsson, J. 2002. Control of Smad7 stability by competition between acetylation and ubiquitination. Mol. Cell 10: 483-493.
-
(2002)
Mol. Cell
, vol.10
, pp. 483-493
-
-
Gronroos, E.1
Hellman, U.2
Heldin, C.H.3
Ericsson, J.4
-
66
-
-
0039844411
-
Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Cα promoter
-
Hanai, J., Chen, L.F., Kanno, T., Ohtani-Fujita, N., Kim, W.Y., Guo, W.H., Imamura, T., Ishidou, Y., Fukuchi, M., Shi, M.J., et al. 1999. Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Cα promoter. J. Biol. Chem. 274: 31577-31582.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 31577-31582
-
-
Hanai, J.1
Chen, L.F.2
Kanno, T.3
Ohtani-Fujita, N.4
Kim, W.Y.5
Guo, W.H.6
Imamura, T.7
Ishidou, Y.8
Fukuchi, M.9
Shi, M.J.10
-
67
-
-
0030825516
-
Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4
-
Hata, A., Lo, R.S., Wotton, D., Lagna, G., and Massagué, J. 1997. Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4. Nature 388: 82-87.
-
(1997)
Nature
, vol.388
, pp. 82-87
-
-
Hata, A.1
Lo, R.S.2
Wotton, D.3
Lagna, G.4
Massagué, J.5
-
68
-
-
0031964859
-
Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor
-
Hata, A., Lagna, G., Massagué, J., and Hemmati-Brivanlou, A. 1998. Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor. Genes & Dev. 12: 186-197.
-
(1998)
Genes & Dev.
, vol.12
, pp. 186-197
-
-
Hata, A.1
Lagna, G.2
Massagué, J.3
Hemmati-Brivanlou, A.4
-
69
-
-
0034695506
-
OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways
-
Hata, A., Seoane, J., Lagna, G., Montalvo, E., Hemmati-Brivanlou, A., and Massagué, J. 2000. OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways. Cell 100: 229-240.
-
(2000)
Cell
, vol.100
, pp. 229-240
-
-
Hata, A.1
Seoane, J.2
Lagna, G.3
Montalvo, E.4
Hemmati-Brivanlou, A.5
Massagué, J.6
-
70
-
-
0031587828
-
The MAD-related protein Smad7 associates with the TGFβ receptor and functions as an antagonist of TGFβ signaling
-
Hayashi, H., Abdollah, S., Qiu, Y., Cai, J., Xu, Y.Y., Grinnell, B.W., Richardson, M.A., Topper, J.N., Gimbrone, M.A., Wrana, J.L., et al. 1997. The MAD-related protein Smad7 associates with the TGFβ receptor and functions as an antagonist of TGFβ signaling. Cell 89: 1165-1173.
-
(1997)
Cell
, vol.89
, pp. 1165-1173
-
-
Hayashi, H.1
Abdollah, S.2
Qiu, Y.3
Cai, J.4
Xu, Y.Y.5
Grinnell, B.W.6
Richardson, M.A.7
Topper, J.N.8
Gimbrone, M.A.9
Wrana, J.L.10
-
71
-
-
0035266183
-
SMAD3 represses androgen receptor-mediated transcription
-
Hayes, S.A., Zarnegar, M., Sharma, M., Yang, F., Peehl, D.M., ten Dijke, P., and Sun, Z. 2001. SMAD3 represses androgen receptor-mediated transcription. Cancer Res. 61: 2112-2118.
-
(2001)
Cancer Res.
, vol.61
, pp. 2112-2118
-
-
Hayes, S.A.1
Zarnegar, M.2
Sharma, M.3
Yang, F.4
Peehl, D.M.5
Ten Dijke, P.6
Sun, Z.7
-
73
-
-
0043234699
-
The transforming activity of Ski and SnoN is dependent on their ability to repress the activity of Smad proteins
-
He, J., Tegen, S.B., Krawitz, A.R., Martin, G.S., and Luo, K. 2003. The transforming activity of Ski and SnoN is dependent on their ability to repress the activity of Smad proteins. J. Biol. Chem. 278: 30540-30547.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 30540-30547
-
-
He, J.1
Tegen, S.B.2
Krawitz, A.R.3
Martin, G.S.4
Luo, K.5
-
74
-
-
13544274478
-
Loss-of-function mutations in LEMD3 result in osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis
-
Hellemans, J., Preobrazhenska, O., Willaert, A., Debeer, P., Verdonk, P.C., Costa, T., Janssens, K., Menten, B., Van Roy, N., Vermeulen, S.J., et al. 2004. Loss-of-function mutations in LEMD3 result in osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis. Nat. Genet. 36: 1213-1218.
-
(2004)
Nat. Genet.
, vol.36
, pp. 1213-1218
-
-
Hellemans, J.1
Preobrazhenska, O.2
Willaert, A.3
Debeer, P.4
Verdonk, P.C.5
Costa, T.6
Janssens, K.7
Menten, B.8
Van Roy, N.9
Vermeulen, S.J.10
-
75
-
-
0033607183
-
Postgastrulation Smad2-deficient embryos show defects in embryo turning and anterior morphogenesis
-
Heyer, J., Escalante-Alcalde, D., Lia, M., Boettinger, E., Edelmann, W., Stewart, C.L., and Kucherlapati, R. 1999. Postgastrulation Smad2-deficient embryos show defects in embryo turning and anterior morphogenesis. Proc. Natl. Acad. Sci. 96: 12595-12600.
-
(1999)
Proc. Natl. Acad. Sci.
, vol.96
, pp. 12595-12600
-
-
Heyer, J.1
Escalante-Alcalde, D.2
Lia, M.3
Boettinger, E.4
Edelmann, W.5
Stewart, C.L.6
Kucherlapati, R.7
-
76
-
-
0035355473
-
The adaptor molecule Disabled-2 links the transforming growth factor β receptors to the Smad pathway
-
Hocevar, B.A., Smine, A., Xu, X.X., and Howe, P.H. 2001. The adaptor molecule Disabled-2 links the transforming growth factor β receptors to the Smad pathway. EMBO J. 20: 2789-2801.
-
(2001)
EMBO J.
, vol.20
, pp. 2789-2801
-
-
Hocevar, B.A.1
Smine, A.2
Xu, X.X.3
Howe, P.H.4
-
77
-
-
0029737070
-
Bone morphogenetic proteins: Multifunctional regulators of vertebrate development
-
Hogan, B.L. 1996. Bone morphogenetic proteins: Multifunctional regulators of vertebrate development. Genes & Dev. 10: 1580-1594.
-
(1996)
Genes & Dev.
, vol.10
, pp. 1580-1594
-
-
Hogan, B.L.1
-
78
-
-
0029892494
-
MADR1, a MAD-related protein that functions in BMP2 signalling pathways
-
Hoodless, P.A., Haerry, T., Abdollah, S., Stapleton, M., O'Connor, M.B., Attisano, L., and Wrana, J.L. 1996. MADR1, a MAD-related protein that functions in BMP2 signalling pathways. Cell 85: 489-500.
-
(1996)
Cell
, vol.85
, pp. 489-500
-
-
Hoodless, P.A.1
Haerry, T.2
Abdollah, S.3
Stapleton, M.4
O'Connor, M.B.5
Attisano, L.6
Wrana, J.L.7
-
79
-
-
13444262316
-
Smad1, β-catenin and Tcf4 associate in a molecular complex with the Myc promoter in dysplastic renal tissue and cooperate to control Myc transcription
-
Hu, M.C. and Rosenblum, N.D. 2005. Smad1, β-catenin and Tcf4 associate in a molecular complex with the Myc promoter in dysplastic renal tissue and cooperate to control Myc transcription. Development 132: 215-225.
-
(2005)
Development
, vol.132
, pp. 215-225
-
-
Hu, M.C.1
Rosenblum, N.D.2
-
80
-
-
0034721771
-
Synergism between transcription factors TFE3 and Smad3 in transforming growth factor-β-induced transcription of the Smad7 gene
-
Hua, X., Miller, Z.A., Benchabane, H., Wrana, J.L., and Lodish, H.F. 2000. Synergism between transcription factors TFE3 and Smad3 in transforming growth factor-β-induced transcription of the Smad7 gene. J. Biol. Chem. 275: 33205-33208.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 33205-33208
-
-
Hua, X.1
Miller, Z.A.2
Benchabane, H.3
Wrana, J.L.4
Lodish, H.F.5
-
81
-
-
0033524943
-
Crystal structure of the cytoplasmic domain of the type I TGF β receptor in complex with FKBP12
-
Huse, M., Chen, Y.G., Massagué, J., and Kuriyan, J. 1999. Crystal structure of the cytoplasmic domain of the type I TGF β receptor in complex with FKBP12. Cell 96: 425-436.
-
(1999)
Cell
, vol.96
, pp. 425-436
-
-
Huse, M.1
Chen, Y.G.2
Massagué, J.3
Kuriyan, J.4
-
82
-
-
0034796457
-
The TGF β receptor activation process: An inhibitor- to substrate-binding switch
-
Huse, M., Muir, T.W., Xu, L., Chen, Y.G., Kuriyan, J., and Massagué, J. 2001. The TGF β receptor activation process: An inhibitor- to substrate-binding switch. Mol. Cell 8: 671-682.
-
(2001)
Mol. Cell
, vol.8
, pp. 671-682
-
-
Huse, M.1
Muir, T.W.2
Xu, L.3
Chen, Y.G.4
Kuriyan, J.5
Massagué, J.6
-
83
-
-
0345491607
-
Drosophila TGIF proteins are transcriptional activators
-
Hyman, C.A., Bartholin, L., Newfeld, S.J., and Wotton, D. 2003. Drosophila TGIF proteins are transcriptional activators. Mol. Cell. Biol. 23: 9262-9274.
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 9262-9274
-
-
Hyman, C.A.1
Bartholin, L.2
Newfeld, S.J.3
Wotton, D.4
-
84
-
-
0030978315
-
Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-β in cells lacking the CDK inhibitor p15
-
Iavarone, A. and Massagué, J. 1997. Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-β in cells lacking the CDK inhibitor p15. Nature 387: 417-422.
-
(1997)
Nature
, vol.387
, pp. 417-422
-
-
Iavarone, A.1
Massagué, J.2
-
85
-
-
0032933352
-
E2F and histone deacetylase mediate transforming growth factor β repression of cdc25A during keratinocyte cell cycle arrest
-
-. 1999. E2F and histone deacetylase mediate transforming growth factor β repression of cdc25A during keratinocyte cell cycle arrest. Mol. Cell. Biol. 19: 916-922.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 916-922
-
-
-
86
-
-
0030765945
-
Smad6 inhibits signalling by the TGF-β superfamily
-
Imamura, T., Takase, M., Nishihara, A., Oeda, E., Hanai, J., Kawabata, M., and Miyazono, K. 1997. Smad6 inhibits signalling by the TGF-β superfamily. Nature 389: 622-626.
-
(1997)
Nature
, vol.389
, pp. 622-626
-
-
Imamura, T.1
Takase, M.2
Nishihara, A.3
Oeda, E.4
Hanai, J.5
Kawabata, M.6
Miyazono, K.7
-
87
-
-
0034675276
-
Amplification and overexpression of TGIF2, a novel homeobox gene of the TALE superclass, in ovarian cancer cell lines
-
Imoto, I., Pimkhaokham, A., Watanabe, T., Saito-Ohara, F., Soeda, E., and Inazawa, J. 2000. Amplification and overexpression of TGIF2, a novel homeobox gene of the TALE superclass, in ovarian cancer cell lines. Biochem. Biophys. Res. Commun. 276: 264-270.
-
(2000)
Biochem. Biophys. Res. Commun.
, vol.276
, pp. 264-270
-
-
Imoto, I.1
Pimkhaokham, A.2
Watanabe, T.3
Saito-Ohara, F.4
Soeda, E.5
Inazawa, J.6
-
88
-
-
0037185010
-
Stoichiometry of active smad-transcription factor complexes on DNA
-
Inman, G.J. and Hill, C.S. 2002. Stoichiometry of active smad-transcription factor complexes on DNA. J. Biol. Chem. 277: 51008-51016.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 51008-51016
-
-
Inman, G.J.1
Hill, C.S.2
-
89
-
-
0036670339
-
Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-β receptor activity
-
Inman, G.J., Nicolas, F.J., and Hill, C.S. 2002. Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-β receptor activity. Mol. Cell 10: 283-294.
-
(2002)
Mol. Cell
, vol.10
, pp. 283-294
-
-
Inman, G.J.1
Nicolas, F.J.2
Hill, C.S.3
-
90
-
-
0034093738
-
Smad6 is a Smad1/5-induced smad inhibitor. Characterization of bone morphogenetic protein-responsive element in the mouse Smad6 promoter
-
Ishida, W., Hamamoto, T., Kusanagi, K., Yagi, K., Kawabata, M., Takehara, K., Sampath, T.K., Kato, M., and Miyazono, K. 2000. Smad6 is a Smad1/5-induced smad inhibitor. Characterization of bone morphogenetic protein-responsive element in the mouse Smad6 promoter. J. Biol. Chem. 275: 6075-6079.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 6075-6079
-
-
Ishida, W.1
Hamamoto, T.2
Kusanagi, K.3
Yagi, K.4
Kawabata, M.5
Takehara, K.6
Sampath, T.K.7
Kato, M.8
Miyazono, K.9
-
91
-
-
0032544594
-
Smad7 is an activin-inducible inhibitor of activin-induced growth arrest and apoptosis in mouse B cells
-
Ishisaki, A., Yamato, K., Nakao, A., Nonaka, K., Ohguchi, M., ten Dijke, P., and Nishihara, T. 1998. Smad7 is an activin-inducible inhibitor of activin-induced growth arrest and apoptosis in mouse B cells. J. Biol. Chem. 273: 24293-24296.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 24293-24296
-
-
Ishisaki, A.1
Yamato, K.2
Nakao, A.3
Nonaka, K.4
Ohguchi, M.5
Ten Dijke, P.6
Nishihara, T.7
-
92
-
-
0032582672
-
Transforming growth factor β1 induces nuclear export of inhibitory Smad7
-
Itoh, S., Landstrom, M., Hermansson, A., Itoh, F., Heldin, C.H., Heldin, N.E., and ten Dijke, P. 1998. Transforming growth factor β1 induces nuclear export of inhibitory Smad7. J. Biol. Chem. 273: 29195-29201.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 29195-29201
-
-
Itoh, S.1
Landstrom, M.2
Hermansson, A.3
Itoh, F.4
Heldin, C.H.5
Heldin, N.E.6
Ten Dijke, P.7
-
93
-
-
0034326828
-
The transcriptional co-activator P/CAF potentiates TGF-β/Smad signaling
-
Itoh, S., Ericsson, J., Nishikawa, J., Heldin, C.H., and ten Dijke, P. 2000. The transcriptional co-activator P/CAF potentiates TGF-β/Smad signaling. Nucleic Acids Res. 28: 4291-4298.
-
(2000)
Nucleic Acids Res.
, vol.28
, pp. 4291-4298
-
-
Itoh, S.1
Ericsson, J.2
Nishikawa, J.3
Heldin, C.H.4
Ten Dijke, P.5
-
94
-
-
0035353203
-
The corepressor CtBP interacts with Evi-1 to repress transforming growth factor β signaling
-
Izutsu, K., Kurokawa, M., Imai, Y., Maki, K., Mitani, K., and Hirai, H. 2001. The corepressor CtBP interacts with Evi-1 to repress transforming growth factor β signaling. Blood 97: 2815-2822.
-
(2001)
Blood
, vol.97
, pp. 2815-2822
-
-
Izutsu, K.1
Kurokawa, M.2
Imai, Y.3
Maki, K.4
Mitani, K.5
Hirai, H.6
-
95
-
-
1942534004
-
Regulation of the TGFβ signalling pathway by ubiquitin-mediated degradation
-
Izzi, L. and Attisano, L. 2004. Regulation of the TGFβ signalling pathway by ubiquitin-mediated degradation. Oncogene 23: 2071-2078.
-
(2004)
Oncogene
, vol.23
, pp. 2071-2078
-
-
Izzi, L.1
Attisano, L.2
-
96
-
-
0034041537
-
Nuclear targeting signal recognition: A key control point in nuclear transport?
-
Jans, D.A., Xiao, C.Y., and Lam, M.H. 2000. Nuclear targeting signal recognition: A key control point in nuclear transport? Bioessays 22: 532-544.
-
(2000)
Bioessays
, vol.22
, pp. 532-544
-
-
Jans, D.A.1
Xiao, C.Y.2
Lam, M.H.3
-
97
-
-
0034731334
-
Distinct oligomeric states of SMAD proteins in the transforming growth factor-β pathway
-
Jayaraman, L. and Massagué, J. 2000. Distinct oligomeric states of SMAD proteins in the transforming growth factor-β pathway. J. Biol. Chem. 275: 40710-40717.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 40710-40717
-
-
Jayaraman, L.1
Massagué, J.2
-
98
-
-
3943099375
-
Protein modification by SUMO
-
Johnson, E.S. 2004. Protein modification by SUMO. Annu. Rev. Biochem. 73: 355-382.
-
(2004)
Annu. Rev. Biochem.
, vol.73
, pp. 355-382
-
-
Johnson, E.S.1
-
99
-
-
0037069936
-
MdmX inhibits Smad transactivation
-
Kadakia, M., Brown, T.L., McGorry, M.M., and Berberich, S.J. 2002. MdmX inhibits Smad transactivation. Oncogene 21: 8776-8785.
-
(2002)
Oncogene
, vol.21
, pp. 8776-8785
-
-
Kadakia, M.1
Brown, T.L.2
McGorry, M.M.3
Berberich, S.J.4
-
100
-
-
0037113990
-
Differential modulation of androgen receptor-mediated transactivation by Smad3 and tumor suppressor Smad4
-
Kang, H.Y., Huang, K.E., Chang, S.Y., Ma, W.L., Lin, W.J., and Chang, C. 2002. Differential modulation of androgen receptor-mediated transactivation by Smad3 and tumor suppressor Smad4. J. Biol. Chem. 277: 43749-43756.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 43749-43756
-
-
Kang, H.Y.1
Huang, K.E.2
Chang, S.Y.3
Ma, W.L.4
Lin, W.J.5
Chang, C.6
-
101
-
-
0038369998
-
A self-enabling TGF response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells
-
Kang, Y., Chen, C.R., and Massagué, J. 2003. A self-enabling TGF response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells. Mol. Cell 11: 915-926.
-
(2003)
Mol. Cell
, vol.11
, pp. 915-926
-
-
Kang, Y.1
Chen, C.R.2
Massagué, J.3
-
102
-
-
23044448510
-
Repression of Runx2 function by TGF-β through recruitment of class II histone deacetylases by Smad3
-
Kang, J.S., Alliston, T., Delston, R., and Derynck, R. 2005. Repression of Runx2 function by TGF-β through recruitment of class II histone deacetylases by Smad3. EMBO J. 24: 2543-2555.
-
(2005)
EMBO J.
, vol.24
, pp. 2543-2555
-
-
Kang, J.S.1
Alliston, T.2
Delston, R.3
Derynck, R.4
-
103
-
-
25444479744
-
Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway
-
Kang, Y., He, W., Tulley, S., Gupta, G.P., Serganova, I., Chen, C.-R., Manova-Todorova, K., Blasberg, R., Gerald, W.L., and Massagué, J. 2005. Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway. Proc. Natl. Acad. Sci. 102: 13909-13914.
-
(2005)
Proc. Natl. Acad. Sci.
, vol.102
, pp. 13909-13914
-
-
Kang, Y.1
He, W.2
Tulley, S.3
Gupta, G.P.4
Serganova, I.5
Chen, C.-R.6
Manova-Todorova, K.7
Blasberg, R.8
Gerald, W.L.9
Massagué, J.10
-
104
-
-
1842457724
-
Transcriptional regulation of BMP4 synexpression in transgenic Xenopus
-
Karaulanov, E., Knochel, W., and Niehrs, C. 2004. Transcriptional regulation of BMP4 synexpression in transgenic Xenopus. EMBO J. 23: 844-856.
-
(2004)
EMBO J.
, vol.23
, pp. 844-856
-
-
Karaulanov, E.1
Knochel, W.2
Niehrs, C.3
-
105
-
-
0037043739
-
A component of the ARC/Mediator complex required for TGF β/Nodal signalling
-
Kato, Y., Habas, R., Katsuyama, Y., Naar, A.M., and He, X. 2002. A component of the ARC/Mediator complex required for TGF β/Nodal signalling. Nature 418: 641-646.
-
(2002)
Nature
, vol.418
, pp. 641-646
-
-
Kato, Y.1
Habas, R.2
Katsuyama, Y.3
Naar, A.M.4
He, X.5
-
106
-
-
0034517389
-
Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF β receptor for degradation
-
Kavsak, P., Rasmussen, R.K., Causing, C.G., Bonni, S., Zhu, H., Thomsen, G.H., and Wrana, J.L. 2000. Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF β receptor for degradation. Mol. Cell 6: 1365-1375.
-
(2000)
Mol. Cell
, vol.6
, pp. 1365-1375
-
-
Kavsak, P.1
Rasmussen, R.K.2
Causing, C.G.3
Bonni, S.4
Zhu, H.5
Thomsen, G.H.6
Wrana, J.L.7
-
107
-
-
0242552528
-
Smad-dependent recruitment of a histone deacetylase/Sin3A complex modulates the bone morphogenetic protein-dependent transcriptional repressor activity of Nkx3.2
-
Kim, D.W. and Lassar, A.B. 2003. Smad-dependent recruitment of a histone deacetylase/Sin3A complex modulates the bone morphogenetic protein-dependent transcriptional repressor activity of Nkx3.2. Mol. Cell. Biol. 23: 8704-8717.
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 8704-8717
-
-
Kim, D.W.1
Lassar, A.B.2
-
108
-
-
0030872367
-
Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic
-
Kim, J., Johnson, K., Chen, H.J., Carroll, S., and Laughon, A. 1997. Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic. Nature 388: 304-308.
-
(1997)
Nature
, vol.388
, pp. 304-308
-
-
Kim, J.1
Johnson, K.2
Chen, H.J.3
Carroll, S.4
Laughon, A.5
-
109
-
-
0034234964
-
A novel smad nuclear interacting protein, SNIP1, suppresses p300-dependent TGF-β signal transduction
-
Kim, R.H., Wang, D., Tsang, M., Martin, J., Huff, C., de Caestecker, M.P., Parks, W.T., Meng, X., Lechleider, R.J., Wang, T., et al. 2000. A novel smad nuclear interacting protein, SNIP1, suppresses p300-dependent TGF-β signal transduction. Genes & Dev. 14: 1605-1616.
-
(2000)
Genes & Dev.
, vol.14
, pp. 1605-1616
-
-
Kim, R.H.1
Wang, D.2
Tsang, M.3
Martin, J.4
Huff, C.5
De Caestecker, M.P.6
Parks, W.T.7
Meng, X.8
Lechleider, R.J.9
Wang, T.10
-
110
-
-
0035947673
-
Repression of dpp targets by binding of brinker to mad sites
-
Kirkpatrick, H., Johnson, K., and Laughon, A. 2001. Repression of dpp targets by binding of brinker to mad sites. J. Biol. Chem. 276: 18216-18222.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 18216-18222
-
-
Kirkpatrick, H.1
Johnson, K.2
Laughon, A.3
-
111
-
-
10744228283
-
Arkadia amplifies TGF-β superfamily signalling through degradation of Smad7
-
Koinuma, D., Shinozaki, M., Komuro, A., Goto, K., Saitoh, M., Hanyu, A., Ebina, A., Nukiwa, T., Miyazawa, K., Imamura, T., et al. 2003. Arkadia amplifies TGF-β superfamily signalling through degradation of Smad7. EMBO J. 22: 6458-6470.
-
(2003)
EMBO J.
, vol.22
, pp. 6458-6470
-
-
Koinuma, D.1
Shinozaki, M.2
Komuro, A.3
Goto, K.4
Saitoh, M.5
Hanyu, A.6
Ebina, A.7
Nukiwa, T.8
Miyazawa, K.9
Imamura, T.10
-
112
-
-
0037085441
-
Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter
-
Korchynskyi, O. and ten Dijke, P. 2002. Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter. J. Biol. Chem. 277: 4883-4891.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 4883-4891
-
-
Korchynskyi, O.1
Ten Dijke, P.2
-
113
-
-
0030773834
-
Opposing BMP and EGF signalling pathway converge on the TGFβ family mediator Smad1
-
Kretzschmar, M., Doody, J., and Massagué, J. 1997. Opposing BMP and EGF signalling pathway converge on the TGFβ family mediator Smad1. Nature 389: 618-622.
-
(1997)
Nature
, vol.389
, pp. 618-622
-
-
Kretzschmar, M.1
Doody, J.2
Massagué, J.3
-
114
-
-
0033106484
-
A mechanism of repression of TGF-β/Smad signaling by oncogenic Ras
-
Kretzschmar, M., Doody, J., Timokhina, I., and Massagué, J. 1999. A mechanism of repression of TGF-β/Smad signaling by oncogenic Ras. Genes & Dev. 13: 804-816.
-
(1999)
Genes & Dev.
, vol.13
, pp. 804-816
-
-
Kretzschmar, M.1
Doody, J.2
Timokhina, I.3
Massagué, J.4
-
115
-
-
0035167095
-
Transforming growth factor-β induces nuclear import of Smad3 in an importin-β1 and Ran-dependent manner
-
Kurisaki, A., Kose, S., Yoneda, Y., Heldin, C.H., and Moustakas, A. 2001. Transforming growth factor-β induces nuclear import of Smad3 in an importin-β1 and Ran-dependent manner. Mol. Biol. Cell 12: 1079-1091.
-
(2001)
Mol. Biol. Cell
, vol.12
, pp. 1079-1091
-
-
Kurisaki, A.1
Kose, S.2
Yoneda, Y.3
Heldin, C.H.4
Moustakas, A.5
-
116
-
-
0032474868
-
The oncoprotein Evi-1 represses TGFβ signalling by inhibiting Smad3
-
Kurokawa, M., Mitani, K., Irie, K., Matsuyama, T., Takahashi, T., Chiba, S., Yazaki, Y., Matsumoto, K., and Hirai, H. 1998. The oncoprotein Evi-1 represses TGFβ signalling by inhibiting Smad3. Nature 394: 92-96.
-
(1998)
Nature
, vol.394
, pp. 92-96
-
-
Kurokawa, M.1
Mitani, K.2
Irie, K.3
Matsuyama, T.4
Takahashi, T.5
Chiba, S.6
Yazaki, Y.7
Matsumoto, K.8
Hirai, H.9
-
117
-
-
0042867243
-
Sumoylation of Smad4, the common Smad mediator of transforming growth factor-β family signaling
-
Lee, P.S., Chang, C., Liu, D., and Derynck, R. 2003. Sumoylation of Smad4, the common Smad mediator of transforming growth factor-β family signaling. J. Biol. Chem. 278: 27853-27863.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 27853-27863
-
-
Lee, P.S.1
Chang, C.2
Liu, D.3
Derynck, R.4
-
118
-
-
0031944290
-
Regulation of immune responses by TGF-β
-
Letterio, J.J. and Roberts, A.B. 1998. Regulation of immune responses by TGF-β. Annu. Rev. Immunol. 16: 137-161.
-
(1998)
Annu. Rev. Immunol.
, vol.16
, pp. 137-161
-
-
Letterio, J.J.1
Roberts, A.B.2
-
119
-
-
2542489214
-
Regulation of Smad4 Sumoylation and transforming growth factor-β signaling by protein inhibitor of activated STAT1
-
Liang, M., Melchior, F., Feng, X.H., and Lin, X. 2004. Regulation of Smad4 Sumoylation and transforming growth factor-β signaling by protein inhibitor of activated STAT1. J. Biol. Chem. 279: 22857-22865.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 22857-22865
-
-
Liang, M.1
Melchior, F.2
Feng, X.H.3
Lin, X.4
-
120
-
-
0037090906
-
Cardiac-specific activity of an Nkx2-5 enhancer requires an evolutionarily conserved Smad binding site
-
Lien, C.L., McAnally, J., Richardson, J.A., and Olson, E.N. 2002. Cardiac-specific activity of an Nkx2-5 enhancer requires an evolutionarily conserved Smad binding site. Dev. Biol. 244: 257-266.
-
(2002)
Dev. Biol.
, vol.244
, pp. 257-266
-
-
Lien, C.L.1
McAnally, J.2
Richardson, J.A.3
Olson, E.N.4
-
121
-
-
0041731797
-
SUMO-1/Ubc9 promotes nuclear accumulation and metabolic stability of tumor suppressor Smad4
-
Lin, X., Liang, M., Liang, Y.Y., Brunicardi, F.C., and Feng, X.H. 2003a. SUMO-1/Ubc9 promotes nuclear accumulation and metabolic stability of tumor suppressor Smad4. J. Biol. Chem. 278: 31043-31048.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 31043-31048
-
-
Lin, X.1
Liang, M.2
Liang, Y.Y.3
Brunicardi, F.C.4
Feng, X.H.5
-
122
-
-
0037805684
-
Activation of transforming growth factor-β signaling by SUMO-1 modification of tumor suppressor Smad4/DPC4
-
Lin, X., Liang, M., Liang, Y.Y., Brunicardi, F.C., Melchior, F., and Feng, X.H. 2003b. Activation of transforming growth factor-β signaling by SUMO-1 modification of tumor suppressor Smad4/DPC4. J. Biol. Chem. 278: 18714-18719.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 18714-18719
-
-
Lin, X.1
Liang, M.2
Liang, Y.Y.3
Brunicardi, F.C.4
Melchior, F.5
Feng, X.H.6
-
123
-
-
0344629431
-
Smad6 recruits transcription corepressor CtBP to repress bone morphogenetic protein-induced transcription
-
Lin, X., Liang, Y.Y., Sun, B., Liang, M., Shi, Y., Brunicardi, F.C., and Feng, X.H. 2003c. Smad6 recruits transcription corepressor CtBP to repress bone morphogenetic protein-induced transcription. Mol. Cell. Biol. 23: 9081-9093.
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 9081-9093
-
-
Lin, X.1
Liang, Y.Y.2
Sun, B.3
Liang, M.4
Shi, Y.5
Brunicardi, F.C.6
Feng, X.H.7
-
124
-
-
4544256756
-
Cytoplasmic PML function in TGF-β signalling
-
Lin, H.K., Bergmann, S., and Pandolfi, P.P. 2004. Cytoplasmic PML function in TGF-β signalling. Nature 431: 205-211.
-
(2004)
Nature
, vol.431
, pp. 205-211
-
-
Lin, H.K.1
Bergmann, S.2
Pandolfi, P.P.3
-
125
-
-
0029931509
-
A human Mad protein acting as a BMP-regulated transcriptional activator
-
Liu, F., Hata, A., Baker, J.C., Doody, J., Carcamo, J., Harland, R.M., and Massagué, J. 1996. A human Mad protein acting as a BMP-regulated transcriptional activator. Nature 381: 620-623.
-
(1996)
Nature
, vol.381
, pp. 620-623
-
-
Liu, F.1
Hata, A.2
Baker, J.C.3
Doody, J.4
Carcamo, J.5
Harland, R.M.6
Massagué, J.7
-
126
-
-
0030690337
-
Dual role of the Smad4/DPC4 tumor suppressor in TGFβ-inducible transcriptional complexes
-
Liu, F., Pouponnot, C., and Massagué, J. 1997. Dual role of the Smad4/DPC4 tumor suppressor in TGFβ-inducible transcriptional complexes. Genes & Dev. 11: 3157-3167.
-
(1997)
Genes & Dev.
, vol.11
, pp. 3157-3167
-
-
Liu, F.1
Pouponnot, C.2
Massagué, J.3
-
127
-
-
0035890328
-
TGF-β inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3
-
Liu, D., Black, B.L., and Derynck, R. 2001. TGF-β inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3. Genes & Dev. 15: 2950-2966.
-
(2001)
Genes & Dev.
, vol.15
, pp. 2950-2966
-
-
Liu, D.1
Black, B.L.2
Derynck, R.3
-
128
-
-
2342514242
-
TGF-β-activated Smad3 represses MEF2-dependent transcription in myogenic differentiation
-
Liu, D., Kang, J.S., and Derynck, R. 2004. TGF-β-activated Smad3 represses MEF2-dependent transcription in myogenic differentiation. EMBO J. 23: 1557-1566.
-
(2004)
EMBO J.
, vol.23
, pp. 1557-1566
-
-
Liu, D.1
Kang, J.S.2
Derynck, R.3
-
129
-
-
0033257926
-
Ubiquitin-dependent degradation of TGF-β-activated Smad2
-
Lo, R.S. and Massagué, J. 1999. Ubiquitin-dependent degradation of TGF-β-activated Smad2. Nat. Cell Biol. 1: 472-478.
-
(1999)
Nat. Cell Biol.
, vol.1
, pp. 472-478
-
-
Lo, R.S.1
Massagué, J.2
-
130
-
-
1842844308
-
Repression of Smad4 transcriptional activity by SUMO modification
-
Long, J., Wang, G., He, D., and Liu, F. 2004. Repression of Smad4 transcriptional activity by SUMO modification. Biochem. J. 379: 23-29.
-
(2004)
Biochem. J.
, vol.379
, pp. 23-29
-
-
Long, J.1
Wang, G.2
He, D.3
Liu, F.4
-
131
-
-
0036479133
-
Direct binding of Smad1 and Smad4 to two distinct motifs mediates bone morphogenetic protein-specific transcriptional activation of Id1 gene
-
Lopez-Rovira, T., Chalaux, E., Massagué, J., Rosa, J.L., and Ventura, F. 2002. Direct binding of Smad1 and Smad4 to two distinct motifs mediates bone morphogenetic protein-specific transcriptional activation of Id1 gene. J. Biol. Chem. 277: 3176-3185.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 3176-3185
-
-
Lopez-Rovira, T.1
Chalaux, E.2
Massagué, J.3
Rosa, J.L.4
Ventura, F.5
-
132
-
-
0030048617
-
Molecular analysis of Evi1, a zinc finger oncogene involved in myeloid leukemia
-
Lopingco, M.C. and Perkins, A.S. 1996. Molecular analysis of Evi1, a zinc finger oncogene involved in myeloid leukemia. Curr. Top. Microbiol. Immunol. 211: 211-222.
-
(1996)
Curr. Top. Microbiol. Immunol.
, vol.211
, pp. 211-222
-
-
Lopingco, M.C.1
Perkins, A.S.2
-
133
-
-
0033200361
-
The Ski oncoprotein interacts with the Smad proteins to repress TGFβ signaling
-
Luo, K., Stroschein, S.L., Wang, W., Chen, D., Martens, E., Zhou, S., and Zhou, Q. 1999. The Ski oncoprotein interacts with the Smad proteins to repress TGFβ signaling. Genes & Dev. 13: 2196-2206.
-
(1999)
Genes & Dev.
, vol.13
, pp. 2196-2206
-
-
Luo, K.1
Stroschein, S.L.2
Wang, W.3
Chen, D.4
Martens, E.5
Zhou, S.6
Zhou, Q.7
-
134
-
-
0032475884
-
Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2
-
Macias-Silva, M., Hoodless, P.A., Tang, S.J., Buchwald, M., and Wrana, J.L. 1998. Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2. J. Biol. Chem. 273: 25628-25636.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 25628-25636
-
-
Macias-Silva, M.1
Hoodless, P.A.2
Tang, S.J.3
Buchwald, M.4
Wrana, J.L.5
-
135
-
-
0035053298
-
Transgenic analysis of the Smad family of TGF-β signal transducers in Drosophila melanogaster suggests new roles and new interactions between family members
-
Marquez, R.M., Singer, M.A., Takaesu, N.T., Waldrip, W.R., Kraytsberg, Y., and Newfeld, S.J. 2001. Transgenic analysis of the Smad family of TGF-β signal transducers in Drosophila melanogaster suggests new roles and new interactions between family members. Genetics 157: 1639-1648.
-
(2001)
Genetics
, vol.157
, pp. 1639-1648
-
-
Marquez, R.M.1
Singer, M.A.2
Takaesu, N.T.3
Waldrip, W.R.4
Kraytsberg, Y.5
Newfeld, S.J.6
-
136
-
-
0242620396
-
Schnurri mediates Dpp-dependent repression of brinker transcription
-
Marty, T., Muller, B., Basler, K., and Affolter, M. 2000. Schnurri mediates Dpp-dependent repression of brinker transcription. Nat. Cell Biol. 2: 745-749.
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 745-749
-
-
Marty, T.1
Muller, B.2
Basler, K.3
Affolter, M.4
-
137
-
-
0031685620
-
TGFβ signal transduction
-
Massagué, J. 1998. TGF signal transduction. Annu. Rev. Biochem. 67: 753-791.
-
(1998)
Annu. Rev. Biochem.
, vol.67
, pp. 753-791
-
-
Massagué, J.1
-
138
-
-
0347991862
-
Integration of Smad and MAPK pathways: A link and a linker revisited
-
-. 2003. Integration of Smad and MAPK pathways: A link and a linker revisited. Genes & Dev. 17: 2993-2997.
-
(2003)
Genes & Dev.
, vol.17
, pp. 2993-2997
-
-
-
139
-
-
9244239811
-
G1 cell-cycle control and cancer
-
-. 2004. G1 cell-cycle control and cancer. Nature 432: 298-306.
-
(2004)
Nature
, vol.432
, pp. 298-306
-
-
-
140
-
-
0034654497
-
Controlling TGF-β signaling
-
Massagué, J. and Chen, Y.G. 2000. Controlling TGF-β signaling. Genes & Dev. 14: 627-644.
-
(2000)
Genes & Dev.
, vol.14
, pp. 627-644
-
-
Massagué, J.1
Chen, Y.G.2
-
141
-
-
0034678908
-
Transcriptional control by the TGF-β/Smad signaling system
-
Massagué, J. and Wotton, D. 2000. Transcriptional control by the TGF-β/Smad signaling system. EMBO J. 19: 1745-1754.
-
(2000)
EMBO J.
, vol.19
, pp. 1745-1754
-
-
Massagué, J.1
Wotton, D.2
-
142
-
-
0034644472
-
TGFβ signaling in growth control, cancer, and heritable disorders
-
Massagué, J., Blain, S.W., and Lo, R.S. 2000. TGFβ signaling in growth control, cancer, and heritable disorders. Cell 103: 295-309.
-
(2000)
Cell
, vol.103
, pp. 295-309
-
-
Massagué, J.1
Blain, S.W.2
Lo, R.S.3
-
143
-
-
3142546336
-
Cyclin-dependent kinases regulate the antiproliferative function of Smads
-
Matsuura, I., Denissova, N.G., Wang, G., He, D., Long, J., and Liu, F. 2004. Cyclin-dependent kinases regulate the antiproliferative function of Smads. Nature 430: 226-231.
-
(2004)
Nature
, vol.430
, pp. 226-231
-
-
Matsuura, I.1
Denissova, N.G.2
Wang, G.3
He, D.4
Long, J.5
Liu, F.6
-
144
-
-
0031707505
-
Nucleocytoplasmic transport: The soluble phase
-
Mattaj, I.W. and Englmeier, L. 1998. Nucleocytoplasmic transport: The soluble phase. Annu. Rev. Biochem. 67: 265-306.
-
(1998)
Annu. Rev. Biochem.
, vol.67
, pp. 265-306
-
-
Mattaj, I.W.1
Englmeier, L.2
-
146
-
-
0034671905
-
The interaction of the carboxyl terminus-binding protein with the Smad corepressor TGIF is disrupted by a holoprosencephaly mutation in TGIF
-
Melhuish, T.A. and Wotton, D. 2000. The interaction of the carboxyl terminus-binding protein with the Smad corepressor TGIF is disrupted by a holoprosencephaly mutation in TGIF. J. Biol. Chem. 275: 39762-39766.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 39762-39766
-
-
Melhuish, T.A.1
Wotton, D.2
-
147
-
-
0035943703
-
TGIF2 interacts with histone deacetylase 1 and represses transcription
-
Melhuish, T.A., Gallo, C.M., and Wotton, D. 2001. TGIF2 interacts with histone deacetylase 1 and represses transcription. J. Biol. Chem. 276: 32109-32114.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 32109-32114
-
-
Melhuish, T.A.1
Gallo, C.M.2
Wotton, D.3
-
148
-
-
0034462833
-
Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA
-
Miura, S., Takeshita, T., Asao, H., Kimura, Y., Murata, K., Sasaki, Y., Hanai, J.L., Beppu, H., Tsukazaki, T., Wrana, J.L., et al. 2000. Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA. Mol. Cell. Biol. 20: 9346-9355.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 9346-9355
-
-
Miura, S.1
Takeshita, T.2
Asao, H.3
Kimura, Y.4
Murata, K.5
Sasaki, Y.6
Hanai, J.L.7
Beppu, H.8
Tsukazaki, T.9
Wrana, J.L.10
-
149
-
-
20444439172
-
Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases
-
Moren, A., Imamura, T., Miyazono, K., Heldin, C.H., and Moustakas, A. 2005. Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases. J. Biol. Chem. 280: 22115-22123.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 22115-22123
-
-
Moren, A.1
Imamura, T.2
Miyazono, K.3
Heldin, C.H.4
Moustakas, A.5
-
150
-
-
0242417167
-
Conversion of an extracellular Dpp/BMP morphogen gradient into an inverse transcriptional gradient
-
Muller, B., Hartmann, B., Pyrowolakis, G., Affolter, M., and Basler, K. 2003. Conversion of an extracellular Dpp/BMP morphogen gradient into an inverse transcriptional gradient. Cell 113: 221-233.
-
(2003)
Cell
, vol.113
, pp. 221-233
-
-
Muller, B.1
Hartmann, B.2
Pyrowolakis, G.3
Affolter, M.4
Basler, K.5
-
151
-
-
0038107486
-
Cooperative inhibition of bone morphogenetic protein signaling by Smurf1 and inhibitory Smads
-
Murakami, G., Watabe, T., Takaoka, K., Miyazono, K., and Imamura, T. 2003. Cooperative inhibition of bone morphogenetic protein signaling by Smurf1 and inhibitory Smads. Mol. Biol. Cell 14: 2809-2817.
-
(2003)
Mol. Biol. Cell
, vol.14
, pp. 2809-2817
-
-
Murakami, G.1
Watabe, T.2
Takaoka, K.3
Miyazono, K.4
Imamura, T.5
-
152
-
-
0036198224
-
Novel targets for the 18p11.3 amplification frequently observed in esophageal squamous cell carcinomas
-
Nakakuki, K., Imoto, I., Pimkhaokham, A., Fukuda, Y., Shimada, Y., Imamura, M., Amagasa, T., and Inazawa, J. 2002. Novel targets for the 18p11.3 amplification frequently observed in esophageal squamous cell carcinomas. Carcinogenesis 23: 19-24.
-
(2002)
Carcinogenesis
, vol.23
, pp. 19-24
-
-
Nakakuki, K.1
Imoto, I.2
Pimkhaokham, A.3
Fukuda, Y.4
Shimada, Y.5
Imamura, M.6
Amagasa, T.7
Inazawa, J.8
-
153
-
-
0030611757
-
Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signaling
-
Nakao, A., Afrakhte, M., Morén, A., Nakayama, T., Christian, J.L., Heuchel, R., Itoh, S., Kawabata, M., Heldin, N.E., Heldin, C.H., et al. 1997. Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signaling. Nature 389: 631-635.
-
(1997)
Nature
, vol.389
, pp. 631-635
-
-
Nakao, A.1
Afrakhte, M.2
Morén, A.3
Nakayama, T.4
Christian, J.L.5
Heuchel, R.6
Itoh, S.7
Kawabata, M.8
Heldin, N.E.9
Heldin, C.H.10
-
154
-
-
0033574767
-
Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300
-
Nakashima, K., Yanagisawa, M., Arakawa, H., Kimura, N., Hisatsune, T., Kawabata, M., Miyazono, K., and Taga, T. 1999. Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300. Science 284: 479-482.
-
(1999)
Science
, vol.284
, pp. 479-482
-
-
Nakashima, K.1
Yanagisawa, M.2
Arakawa, H.3
Kimura, N.4
Hisatsune, T.5
Kawabata, M.6
Miyazono, K.7
Taga, T.8
-
155
-
-
0035848854
-
Arkadia enhances nodal-related signalling to induce mesendoderm
-
Niederlander, C., Walsh, J.J., Episkopou, V., and Jones, C.M. 2001. Arkadia enhances nodal-related signalling to induce mesendoderm. Nature 410: 830-834.
-
(2001)
Nature
, vol.410
, pp. 830-834
-
-
Niederlander, C.1
Walsh, J.J.2
Episkopou, V.3
Jones, C.M.4
-
156
-
-
0037007643
-
Modular feedback
-
Niehrs, C. and Meinhardt, H. 2002. Modular feedback. Nature 417: 35-36.
-
(2002)
Nature
, vol.417
, pp. 35-36
-
-
Niehrs, C.1
Meinhardt, H.2
-
157
-
-
0033518256
-
Synexpression groups in eukaryotes
-
Niehrs, C. and Pollet, N. 1999. Synexpression groups in eukaryotes. Nature 402: 483-487.
-
(1999)
Nature
, vol.402
, pp. 483-487
-
-
Niehrs, C.1
Pollet, N.2
-
158
-
-
0034677494
-
Interaction between Wnt and TGF-β signalling pathways during formation of Spemann's organizer
-
Nishita, M., Hashimoto, M.K., Ogata, S., Laurent, M.N., Ueno, N., Shibuya, H., and Cho, K.W. 2000. Interaction between Wnt and TGF-β signalling pathways during formation of Spemann's organizer. Nature 403: 781-785.
-
(2000)
Nature
, vol.403
, pp. 781-785
-
-
Nishita, M.1
Hashimoto, M.K.2
Ogata, S.3
Laurent, M.N.4
Ueno, N.5
Shibuya, H.6
Cho, K.W.7
-
159
-
-
0033557497
-
Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor
-
Nomura, T., Khan, M.M., Kaul, S.C., Dong, H.D., Wadhwa, R., Colmenares, C., Kohno, I., and Ishii, S. 1999. Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor. Genes & Dev. 13: 412-423.
-
(1999)
Genes & Dev.
, vol.13
, pp. 412-423
-
-
Nomura, T.1
Khan, M.M.2
Kaul, S.C.3
Dong, H.D.4
Wadhwa, R.5
Colmenares, C.6
Kohno, I.7
Ishii, S.8
-
160
-
-
0030606239
-
The transcriptional coactivators p300 and CBP are histone acetyltransferases
-
Ogryzko, V.V., Schiltz, R.L., Russanova, V., Howard, B.H., and Nakatani, Y. 1996. The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell 87: 953-959.
-
(1996)
Cell
, vol.87
, pp. 953-959
-
-
Ogryzko, V.V.1
Schiltz, R.L.2
Russanova, V.3
Howard, B.H.4
Nakatani, Y.5
-
161
-
-
0347065367
-
Transforming growth factor-β-mediated signaling via the p38 MAP kinase pathway activates Smad-dependent transcription through SUMO-1 modification of Smad4
-
Ohshima, T. and Shimotohno, K. 2003. Transforming growth factor-β-mediated signaling via the p38 MAP kinase pathway activates Smad-dependent transcription through SUMO-1 modification of Smad4. J. Biol. Chem. 278: 50833-50842.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 50833-50842
-
-
Ohshima, T.1
Shimotohno, K.2
-
162
-
-
0033619255
-
Silencing of TGF-β signalling by the pseudoreceptor BAMBI
-
Onichtchouk, D., Chen, Y.G., Dosch, R., Gawantka, V., Delius, H., Massagué, J., and Niehrs, C. 1999. Silencing of TGF-β signalling by the pseudoreceptor BAMBI. Nature 401: 480-485.
-
(1999)
Nature
, vol.401
, pp. 480-485
-
-
Onichtchouk, D.1
Chen, Y.G.2
Dosch, R.3
Gawantka, V.4
Delius, H.5
Massagué, J.6
Niehrs, C.7
-
163
-
-
0030579203
-
TGF-β receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis
-
Oshima, M., Oshima, H., and Taketo, M.M. 1996. TGF-β receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis. Dev. Biol. 179: 297-302.
-
(1996)
Dev. Biol.
, vol.179
, pp. 297-302
-
-
Oshima, M.1
Oshima, H.2
Taketo, M.M.3
-
164
-
-
14844364701
-
Regulation of the polarity protein Par6 by TGFβ receptors controls epithelial cell plasticity
-
Ozdamar, B., Bose, R., Barrios-Rodiles, M., Wang, H.R., Zhang, Y., and Wrana, J.L. 2005. Regulation of the polarity protein Par6 by TGFβ receptors controls epithelial cell plasticity. Science 307: 1603-1609.
-
(2005)
Science
, vol.307
, pp. 1603-1609
-
-
Ozdamar, B.1
Bose, R.2
Barrios-Rodiles, M.3
Wang, H.R.4
Zhang, Y.5
Wrana, J.L.6
-
165
-
-
18144411595
-
The integral inner nuclear membrane protein MAN1 physically interacts with the R-Smad proteins to repress signaling by the transforming growth factor-β superfamily of cytokines
-
Pan, D., Estevez-Salmeron, L.D., Stroschein, S.L., Zhu, X., He, J., Zhou, S., and Luo, K. 2005. The integral inner nuclear membrane protein MAN1 physically interacts with the R-Smad proteins to repress signaling by the transforming growth factor-β superfamily of cytokines. J. Biol. Chem. 280: 15992-16001.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 15992-16001
-
-
Pan, D.1
Estevez-Salmeron, L.D.2
Stroschein, S.L.3
Zhu, X.4
He, J.5
Zhou, S.6
Luo, K.7
-
166
-
-
0034603004
-
Smad and AML proteins synergistically confer transforming growth factor β1 responsiveness to human germline IgA genes
-
Pardali, E., Xie, X.Q., Tsapogas, P., Itoh, S., Arvanitidis, K., Heldin, C.H., ten Dijke, P., Grundstrom, T., and Sideras, P. 2000. Smad and AML proteins synergistically confer transforming growth factor β1 responsiveness to human germline IgA genes. J. Biol. Chem. 275: 3552-3560.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 3552-3560
-
-
Pardali, E.1
Xie, X.Q.2
Tsapogas, P.3
Itoh, S.4
Arvanitidis, K.5
Heldin, C.H.6
Ten Dijke, P.7
Grundstrom, T.8
Sideras, P.9
-
167
-
-
0034703083
-
Role of Smad proteins and transcription factor Sp1 in p21(Waf1/Cip1) regulation by transforming growth factor-β
-
Pardali, K., Kurisaki, A., Moren, A., ten Dijke, P., Kardassis, D., and Moustakas, A. 2000. Role of Smad proteins and transcription factor Sp1 in p21(Waf1/Cip1) regulation by transforming growth factor-β. J. Biol. Chem. 275: 29244-29256.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 29244-29256
-
-
Pardali, K.1
Kurisaki, A.2
Moren, A.3
Ten Dijke, P.4
Kardassis, D.5
Moustakas, A.6
-
168
-
-
0346594337
-
Integration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural induction
-
Pera, E.M., Ikeda, A., Eivers, E., and De Robertis, E.M. 2003. Integration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural induction. Genes & Dev. 17: 3023-3028.
-
(2003)
Genes & Dev.
, vol.17
, pp. 3023-3028
-
-
Pera, E.M.1
Ikeda, A.2
Eivers, E.3
De Robertis, E.M.4
-
169
-
-
0034460336
-
Transforming growth factor β-independent shuttling of Smad4 between the cytoplasm and nucleus
-
Pierreux, C.E., Nicolas, F.J., and Hill, C.S. 2000. Transforming growth factor β-independent shuttling of Smad4 between the cytoplasm and nucleus. Mol. Cell. Biol. 20: 9041-9054.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 9041-9054
-
-
Pierreux, C.E.1
Nicolas, F.J.2
Hill, C.S.3
-
170
-
-
0035489160
-
The DSmurf ubiquitin-protein ligase restricts BMP signaling spatially and temporally during Drosophila embryogenesis
-
Podos, S.D., Hanson, K.K., Wang, Y.C., and Ferguson, E.L. 2001. The DSmurf ubiquitin-protein ligase restricts BMP signaling spatially and temporally during Drosophila embryogenesis. Dev. Cell 1: 567-578.
-
(2001)
Dev. Cell
, vol.1
, pp. 567-578
-
-
Podos, S.D.1
Hanson, K.K.2
Wang, Y.C.3
Ferguson, E.L.4
-
171
-
-
0032483493
-
Physical and functional interactions of Smads and p300/CBP
-
Pouponnot, C., Jayaraman, L., and Massagué, J. 1998. Physical and functional interactions of Smads and p300/CBP. J. Biol. Chem. 273: 22865-22868.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 22865-22868
-
-
Pouponnot, C.1
Jayaraman, L.2
Massagué, J.3
-
172
-
-
0035695116
-
Structural basis of Smad1 activation by receptor kinase phosphorylation
-
Qin, B.Y., Chacko, B.M., Lam, S.S., de Caestecker, M.P., Correia, J.J., and Lin, K. 2001. Structural basis of Smad1 activation by receptor kinase phosphorylation. Mol. Cell 8: 1303-1312.
-
(2001)
Mol. Cell
, vol.8
, pp. 1303-1312
-
-
Qin, B.Y.1
Chacko, B.M.2
Lam, S.S.3
De Caestecker, M.P.4
Correia, J.J.5
Lin, K.6
-
173
-
-
0033564526
-
TGF-β family signal transduction in Drosophila development: From Mad to Smads
-
Raftery, L.A. and Sutherland, D.J. 1999. TGF-β family signal transduction in Drosophila development: From Mad to Smads. Dev. Biol. 210: 251-268.
-
(1999)
Dev. Biol.
, vol.210
, pp. 251-268
-
-
Raftery, L.A.1
Sutherland, D.J.2
-
174
-
-
0037080983
-
Different Smad2 partners bind a common hydrophobic pocket in Smad2 via a defined proline-rich motif
-
Randall, R.A., Germain, S., Inman, G.J., Bates, P.A., and Hill, C.S. 2002. Different Smad2 partners bind a common hydrophobic pocket in Smad2 via a defined proline-rich motif. EMBO J. 21: 145-156.
-
(2002)
EMBO J.
, vol.21
, pp. 145-156
-
-
Randall, R.A.1
Germain, S.2
Inman, G.J.3
Bates, P.A.4
Hill, C.S.5
-
175
-
-
0034695924
-
The yeast nuclear pore complex: Composition, architecture, and transport mechanism
-
Rout, M.P., Aitchison, J.D., Suprapto, A., Hjertaas, K., Zhao, Y., and Chait, B.T. 2000. The yeast nuclear pore complex: Composition, architecture, and transport mechanism. J. Cell Biol. 148: 635-651.
-
(2000)
J. Cell Biol.
, vol.148
, pp. 635-651
-
-
Rout, M.P.1
Aitchison, J.D.2
Suprapto, A.3
Hjertaas, K.4
Zhao, Y.5
Chait, B.T.6
-
176
-
-
0035252544
-
Transcriptional regulation of the Drosophila gene zen by competing Smad and Brinker inputs
-
Rushlow, C., Colosimo, P.F., Lin, M.C., Xu, M., and Kirov, N. 2001. Transcriptional regulation of the Drosophila gene zen by competing Smad and Brinker inputs. Genes & Dev. 15: 340-351.
-
(2001)
Genes & Dev.
, vol.15
, pp. 340-351
-
-
Rushlow, C.1
Colosimo, P.F.2
Lin, M.C.3
Xu, M.4
Kirov, N.5
-
177
-
-
0345255908
-
Nodal signaling in vertebrate development
-
Schier, A.F. 2003. Nodal signaling in vertebrate development. Annu. Rev. Cell Dev. Biol. 19: 589-621.
-
(2003)
Annu. Rev. Cell Dev. Biol.
, vol.19
, pp. 589-621
-
-
Schier, A.F.1
-
178
-
-
0346100493
-
PIAS/SUMO: New partners in transcriptional regulation
-
Schmidt, D. and Muller, S. 2003. PIAS/SUMO: New partners in transcriptional regulation. Cell. Mol. Life Sci. 60: 2561-2574.
-
(2003)
Cell. Mol. Life Sci.
, vol.60
, pp. 2561-2574
-
-
Schmidt, D.1
Muller, S.2
-
179
-
-
6344260070
-
The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation
-
Seo, S.R., Lallemand, F., Ferrand, N., Pessah, M., L'Hoste, S., Camonis, J., and Atfi, A. 2004. The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation. EMBO J. 23: 3780-3792.
-
(2004)
EMBO J.
, vol.23
, pp. 3780-3792
-
-
Seo, S.R.1
Lallemand, F.2
Ferrand, N.3
Pessah, M.4
L'Hoste, S.5
Camonis, J.6
Atfi, A.7
-
180
-
-
0034744956
-
TGFβ influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b
-
Seoane, J., Pouponnot, C., Staller, P., Schader, M., Eilers, M., and Massagué, J. 2001. TGFβ influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b. Nat. Cell Biol. 3: 400-408.
-
(2001)
Nat. Cell Biol.
, vol.3
, pp. 400-408
-
-
Seoane, J.1
Pouponnot, C.2
Staller, P.3
Schader, M.4
Eilers, M.5
Massagué, J.6
-
181
-
-
0037126303
-
Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage
-
Seoane, J., Le, H.V., and Massagué, J. 2002. Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage. Nature 419: 729-734.
-
(2002)
Nature
, vol.419
, pp. 729-734
-
-
Seoane, J.1
Le, H.V.2
Massagué, J.3
-
182
-
-
1642332084
-
Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation
-
Seoane, J., Le, H.V., Shen, L., Anderson, S.A., and Massagué, J. 2004. Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation. Cell 117: 211-223.
-
(2004)
Cell
, vol.117
, pp. 211-223
-
-
Seoane, J.1
Le, H.V.2
Shen, L.3
Anderson, S.A.4
Massagué, J.5
-
183
-
-
0031773264
-
TGF-β-induced phosphorylation of Smad3 regulates its interaction with coactivator p300/CREB-binding protein
-
Shen, X., Hu, P.P., Liberati, N.T., Datto, M.B., Frederick, J.P., and Wang, X.F. 1998. TGF-β-induced phosphorylation of Smad3 regulates its interaction with coactivator p300/CREB-binding protein. Mol. Biol. Cell 9: 3309-3319.
-
(1998)
Mol. Biol. Cell
, vol.9
, pp. 3309-3319
-
-
Shen, X.1
Hu, P.P.2
Liberati, N.T.3
Datto, M.B.4
Frederick, J.P.5
Wang, X.F.6
-
184
-
-
0038682002
-
Mechanisms of TGF-β signaling from cell membrane to the nucleus
-
Shi, Y. and Massagué, J. 2003. Mechanisms of TGF-β signaling from cell membrane to the nucleus. Cell 113: 685-700.
-
(2003)
Cell
, vol.113
, pp. 685-700
-
-
Shi, Y.1
Massagué, J.2
-
185
-
-
0030837455
-
A structural basis for mutational inactivation of the tumour suppressor Smad4
-
Shi, Y., Hata, A., Lo, R.S., Massagué, J., and Pavletich, N.P. 1997. A structural basis for mutational inactivation of the tumour suppressor Smad4. Nature 388: 87-93.
-
(1997)
Nature
, vol.388
, pp. 87-93
-
-
Shi, Y.1
Hata, A.2
Lo, R.S.3
Massagué, J.4
Pavletich, N.P.5
-
186
-
-
0032483544
-
Crystal structure of a Smad MH1 domain bound to DNA: Insights on DNA binding in TGF-β signaling
-
Shi, Y., Wang, Y.F., Jayaraman, L., Yang, H., Massagué, J., and Pavletich, N.P. 1998. Crystal structure of a Smad MH1 domain bound to DNA: Insights on DNA binding in TGF-β signaling. Cell 94: 585-594.
-
(1998)
Cell
, vol.94
, pp. 585-594
-
-
Shi, Y.1
Wang, Y.F.2
Jayaraman, L.3
Yang, H.4
Massagué, J.5
Pavletich, N.P.6
-
187
-
-
0037100660
-
Bone morphogenetic protein-4-induced activation of Xretpos is mediated by Smads and Olf-1/EBF associated zinc finger (OAZ)
-
Shim, S., Bae, N., and Han, J.K. 2002. Bone morphogenetic protein-4-induced activation of Xretpos is mediated by Smads and Olf-1/EBF associated zinc finger (OAZ). Nucleic Acids Res. 30: 3107-3117.
-
(2002)
Nucleic Acids Res.
, vol.30
, pp. 3107-3117
-
-
Shim, S.1
Bae, N.2
Han, J.K.3
-
188
-
-
0035024425
-
Swift is a novel BRCT domain coactivator of Smad2 in transforming growth factor β signaling
-
Shimizu, K., Bourillot, P.Y., Nielsen, S.J., Zorn, A.M., and Gurdon, J.B. 2001. Swift is a novel BRCT domain coactivator of Smad2 in transforming growth factor β signaling. Mol. Cell. Biol. 21: 3901-3912.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 3901-3912
-
-
Shimizu, K.1
Bourillot, P.Y.2
Nielsen, S.J.3
Zorn, A.M.4
Gurdon, J.B.5
-
189
-
-
0032544076
-
Transcriptional activating activity of Smad4: Roles of SMAD hetero-oligomerization and enhancement by an associating transactivator
-
Shioda, T., Lechleider, R.J., Dunwoodie, S.L., Li, H., Yahata, T., de Caestecker, M.P., Fenner, M.H., Roberts, A.B., and Isselbacher, K.J. 1998. Transcriptional activating activity of Smad4: Roles of SMAD hetero- oligomerization and enhancement by an associating transactivator. Proc. Natl. Acad. Sci. 95: 9785-9790.
-
(1998)
Proc. Natl. Acad. Sci.
, vol.95
, pp. 9785-9790
-
-
Shioda, T.1
Lechleider, R.J.2
Dunwoodie, S.L.3
Li, H.4
Yahata, T.5
De Caestecker, M.P.6
Fenner, M.H.7
Roberts, A.B.8
Isselbacher, K.J.9
-
190
-
-
0242499448
-
Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer
-
Siegel, P.M. and Massagué, J. 2003. Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer. Nat. Rev. Cancer 3: 807-821.
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 807-821
-
-
Siegel, P.M.1
Massagué, J.2
-
191
-
-
0042316912
-
Mad upregulation and Id2 repression accompany transforming growth factor (TGF)-β-mediated epithelial cell growth suppression
-
Siegel, P.M., Shu, W., and Massagué, J. 2003. Mad upregulation and Id2 repression accompany transforming growth factor (TGF)-β-mediated epithelial cell growth suppression. J. Biol. Chem. 278: 35444-35450.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 35444-35450
-
-
Siegel, P.M.1
Shu, W.2
Massagué, J.3
-
192
-
-
15444348295
-
The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo
-
Sirard, C., de la Pompa, J.L., Elia, A., Itie, A., Mirtsos, C., Cheung, A., Hahn, S., Wakeham, A., Schwartz, L., Kern, S.E., et al. 1998. The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo. Genes & Dev. 12: 107-119.
-
(1998)
Genes & Dev.
, vol.12
, pp. 107-119
-
-
Sirard, C.1
De La Pompa, J.L.2
Elia, A.3
Itie, A.4
Mirtsos, C.5
Cheung, A.6
Hahn, S.7
Wakeham, A.8
Schwartz, L.9
Kern, S.E.10
-
193
-
-
5144219680
-
Identification of a SUMO-binding motif that recognizes SUMO-modified proteins
-
Song, J., Durrin, L.K., Wilkinson, T.A., Krontiris, T.G., and Chen, Y. 2004. Identification of a SUMO-binding motif that recognizes SUMO-modified proteins. Proc. Natl. Acad. Sci. 101: 14373-14378.
-
(2004)
Proc. Natl. Acad. Sci.
, vol.101
, pp. 14373-14378
-
-
Song, J.1
Durrin, L.K.2
Wilkinson, T.A.3
Krontiris, T.G.4
Chen, Y.5
-
194
-
-
0032566611
-
Physical and functional interaction of murine and Xenopus Smad7 with bone morphogenetic protein receptors and transforming growth factor-β receptors
-
Souchelnytskyi, S., Nakayama, T., Nakao, A., Moren, A., Heldin, C.H., Christian, J.L., and ten Dijke, P. 1998. Physical and functional interaction of murine and Xenopus Smad7 with bone morphogenetic protein receptors and transforming growth factor-β receptors. J. Biol. Chem. 273: 25364-25370.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 25364-25370
-
-
Souchelnytskyi, S.1
Nakayama, T.2
Nakao, A.3
Moren, A.4
Heldin, C.H.5
Christian, J.L.6
Ten Dijke, P.7
-
195
-
-
0034744957
-
Repression of p15INK4b expression by Myc through association with Miz-1
-
Staller, P., Peukert, K., Kiermaier, A., Seoane, J., Lukas, J., Karsunky, H., Moroy, T., Bartek, J., Massagué, J., Hanel, F., et al. 2001. Repression of p15INK4b expression by Myc through association with Miz-1. Nat. Cell Biol. 3: 392-399.
-
(2001)
Nat. Cell Biol.
, vol.3
, pp. 392-399
-
-
Staller, P.1
Peukert, K.2
Kiermaier, A.3
Seoane, J.4
Lukas, J.5
Karsunky, H.6
Moroy, T.7
Bartek, J.8
Massagué, J.9
Hanel, F.10
-
196
-
-
0022628093
-
Transforming Sloan-Kettering viruses generated from the cloned v-ski oncogene by in vitro and in vivo recombinations
-
Stavnezer, E., Barkas, A.E., Brennan, L.A., Brodeur, D., and Li, Y. 1986. Transforming Sloan-Kettering viruses generated from the cloned v-ski oncogene by in vitro and in vivo recombinations. J. Virol. 57: 1073-1083.
-
(1986)
J. Virol.
, vol.57
, pp. 1073-1083
-
-
Stavnezer, E.1
Barkas, A.E.2
Brennan, L.A.3
Brodeur, D.4
Li, Y.5
-
197
-
-
0034703087
-
Participation of Smad2, Smad3, and Smad4 in transforming growth factor (TGF-β)-induced activation of Smad7. THE TGF-β response element of the promoter requires functional Smad binding element and E-box sequences for transcriptional regulation
-
Stopa, M., Anhuf, D., Terstegen, L., Gatsios, P., Gressner, A.M., and Dooley, S. 2000. Participation of Smad2, Smad3, and Smad4 in transforming growth factor (TGF-β)-induced activation of Smad7. THE TGF-β response element of the promoter requires functional Smad binding element and E-box sequences for transcriptional regulation. J. Biol. Chem. 275: 29308-29317.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 29308-29317
-
-
Stopa, M.1
Anhuf, D.2
Terstegen, L.3
Gatsios, P.4
Gressner, A.M.5
Dooley, S.6
-
198
-
-
0033595704
-
Negative feedback regulation of TGF-β signaling by the SnoN oncoprotein
-
Stroschein, S.L., Wang, W., Zhou, S., Zhou, Q., and Luo, K. 1999. Negative feedback regulation of TGF-β signaling by the SnoN oncoprotein. Science 286: 771-774.
-
(1999)
Science
, vol.286
, pp. 771-774
-
-
Stroschein, S.L.1
Wang, W.2
Zhou, S.3
Zhou, Q.4
Luo, K.5
-
199
-
-
0035498980
-
Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN
-
Stroschein, S.L., Bonni, S., Wrana, J.L., and Luo, K. 2001. Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN. Genes & Dev. 15: 2822-2836.
-
(2001)
Genes & Dev.
, vol.15
, pp. 2822-2836
-
-
Stroschein, S.L.1
Bonni, S.2
Wrana, J.L.3
Luo, K.4
-
200
-
-
3442894138
-
Targeting endogenous transforming growth factor β receptor signaling in SMAD4-deficient human pancreatic carcinoma cells inhibits their invasive phenotype1
-
Subramanian, G., Schwarz, R.E., Higgins, L., McEnroe, G., Chakravarty, S., Dugar, S., and Reiss, M. 2004. Targeting endogenous transforming growth factor β receptor signaling in SMAD4-deficient human pancreatic carcinoma cells inhibits their invasive phenotype1. Cancer Res. 64: 5200-5211.
-
(2004)
Cancer Res.
, vol.64
, pp. 5200-5211
-
-
Subramanian, G.1
Schwarz, R.E.2
Higgins, L.3
McEnroe, G.4
Chakravarty, S.5
Dugar, S.6
Reiss, M.7
-
201
-
-
0033213606
-
Interaction of the Ski oncoprotein with Smad3 regulates TGF-β signaling
-
Sun, Y., Liu, X., Eaton, E.N., Lane, W.S., Lodish, H.F., and Weinberg, R.A. 1999a. Interaction of the Ski oncoprotein with Smad3 regulates TGF-β signaling. Mol. Cell 4: 499-509.
-
(1999)
Mol. Cell
, vol.4
, pp. 499-509
-
-
Sun, Y.1
Liu, X.2
Eaton, E.N.3
Lane, W.S.4
Lodish, H.F.5
Weinberg, R.A.6
-
202
-
-
0033607240
-
SnoN and ski protooncoproteins are rapidly degraded in response to transforming growth factor β signaling
-
Sun, Y., Liu, X., Ng-Eaton, E., Lodish, H.F., and Weinberg, R.A. 1999b. SnoN and ski protooncoproteins are rapidly degraded in response to transforming growth factor β signaling. Proc. Natl. Acad. Sci. 96: 12442-12447.
-
(1999)
Proc. Natl. Acad. Sci.
, vol.96
, pp. 12442-12447
-
-
Sun, Y.1
Liu, X.2
Ng-Eaton, E.3
Lodish, H.F.4
Weinberg, R.A.5
-
203
-
-
0035830503
-
Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms
-
Sun, Y., Nadal-Vicens, M., Misono, S., Lin, M.Z., Zubiaga, A., Hua, X., Fan, G., and Greenberg, M.E. 2001. Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms. Cell 104: 365-376.
-
(2001)
Cell
, vol.104
, pp. 365-376
-
-
Sun, Y.1
Nadal-Vicens, M.2
Misono, S.3
Lin, M.Z.4
Zubiaga, A.5
Hua, X.6
Fan, G.7
Greenberg, M.E.8
-
204
-
-
0037131283
-
Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane
-
Suzuki, C., Murakami, G., Fukuchi, M., Shimanuki, T., Shikauchi, Y., Imamura, T., and Miyazono, K. 2002. Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane. J. Biol. Chem. 277: 39919-39925.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 39919-39925
-
-
Suzuki, C.1
Murakami, G.2
Fukuchi, M.3
Shimanuki, T.4
Shikauchi, Y.5
Imamura, T.6
Miyazono, K.7
-
205
-
-
0038363366
-
Chromosomal region maintenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-β signaling by Smad7
-
Tajima, Y., Goto, K., Yoshida, M., Shinomiya, K., Sekimoto, T., Yoneda, Y., Miyazono, K., and Imamura, T. 2003. Chromosomal region maintenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-β signaling by Smad7. J. Biol. Chem. 278: 10716-10721.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 10716-10721
-
-
Tajima, Y.1
Goto, K.2
Yoshida, M.3
Shinomiya, K.4
Sekimoto, T.5
Yoneda, Y.6
Miyazono, K.7
Imamura, T.8
-
206
-
-
12144291415
-
Interaction with Smad4 is indispensable for suppression of BMP signaling by c-Ski
-
Takeda, M., Mizuide, M., Oka, M., Watabe, T., Inoue, H., Suzuki, H., Fujita, T., Imamura, T., Miyazono, K., and Miyazawa, K. 2004. Interaction with Smad4 is indispensable for suppression of BMP signaling by c-Ski. Mol. Biol. Cell 15: 963-972.
-
(2004)
Mol. Biol. Cell
, vol.15
, pp. 963-972
-
-
Takeda, M.1
Mizuide, M.2
Oka, M.3
Watabe, T.4
Inoue, H.5
Suzuki, H.6
Fujita, T.7
Imamura, T.8
Miyazono, K.9
Miyazawa, K.10
-
207
-
-
0031778749
-
The Tlx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development
-
Tang, S.J., Hoodless, P.A., Lu, Z., Breitman, M.L., McInnes, R.R., Wrana, J.L., and Buchwald, M. 1998. The Tlx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development. Development 125: 1877-1887.
-
(1998)
Development
, vol.125
, pp. 1877-1887
-
-
Tang, S.J.1
Hoodless, P.A.2
Lu, Z.3
Breitman, M.L.4
McInnes, R.R.5
Wrana, J.L.6
Buchwald, M.7
-
208
-
-
0037462502
-
Disruption of transforming growth factor-β signaling in ELF β-spectrin-deficient mice
-
Tang, Y., Katuri, V., Dillner, A., Mishra, B., Deng, C.X., and Mishra, L. 2003. Disruption of transforming growth factor-β signaling in ELF β-spectrin-deficient mice. Science 299: 574-577.
-
(2003)
Science
, vol.299
, pp. 574-577
-
-
Tang, Y.1
Katuri, V.2
Dillner, A.3
Mishra, B.4
Deng, C.X.5
Mishra, L.6
-
209
-
-
0036333793
-
Wnt and Bmp signalling cooperatively regulate graded Emx2 expression in the dorsal telencephalon
-
Theil, T., Aydin, S., Koch, S., Grotewold, L., and Ruther, U. 2002. Wnt and Bmp signalling cooperatively regulate graded Emx2 expression in the dorsal telencephalon. Development 129: 3045-3054.
-
(2002)
Development
, vol.129
, pp. 3045-3054
-
-
Theil, T.1
Aydin, S.2
Koch, S.3
Grotewold, L.4
Ruther, U.5
-
210
-
-
0032482946
-
CREB binding protein is a required coactivator for Smad-dependent, transforming growth factor β transcriptional responses in endothelial cells
-
Topper, J.N., DiChiara, M.R., Brown, J.D., Williams, A.J., Falb, D., Collins, T., and Gimbrone Jr., M.A. 1998. CREB binding protein is a required coactivator for Smad-dependent, transforming growth factor β transcriptional responses in endothelial cells. Proc. Natl. Acad. Sci. 95: 9506-9511.
-
(1998)
Proc. Natl. Acad. Sci.
, vol.95
, pp. 9506-9511
-
-
Topper, J.N.1
DiChiara, M.R.2
Brown, J.D.3
Williams, A.J.4
Falb, D.5
Collins, T.6
Gimbrone Jr., M.A.7
-
211
-
-
0036170142
-
Identification of Sef, a novel modulator of FGF signalling
-
Tsang, M., Friesel, R., Kudoh, T., and Dawid, I.B. 2002. Identification of Sef, a novel modulator of FGF signalling. Nat. Cell Biol. 4: 165-169.
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 165-169
-
-
Tsang, M.1
Friesel, R.2
Kudoh, T.3
Dawid, I.B.4
-
212
-
-
0032428684
-
SARA, a FYVE domain protein that recruits Smad2 to the TGFβ receptor
-
Tsukazaki, T., Chiang, T.A., Davison, A.F., Attisano, L., and Wrana, J.L. 1998. SARA, a FYVE domain protein that recruits Smad2 to the TGFβ receptor. Cell 95: 779-791.
-
(1998)
Cell
, vol.95
, pp. 779-791
-
-
Tsukazaki, T.1
Chiang, T.A.2
Davison, A.F.3
Attisano, L.4
Wrana, J.L.5
-
213
-
-
0030863365
-
Daughters against dpp modulates dpp organizing activity in Drosophila wing development
-
Tsuneizumi, K., Nakayama, T., Kamoshida, Y., Kornberg, T.B., Christian, J.L., and Tabata, T. 1997. Daughters against dpp modulates dpp organizing activity in Drosophila wing development. Nature 389: 627-631.
-
(1997)
Nature
, vol.389
, pp. 627-631
-
-
Tsuneizumi, K.1
Nakayama, T.2
Kamoshida, Y.3
Kornberg, T.B.4
Christian, J.L.5
Tabata, T.6
-
214
-
-
0033602101
-
Inhibition of transforming growth factor-β/SMAD signalling by the interferon-γ/STAT pathway
-
Ulloa, L., Doody, J., and Massagué, J. 1999. Inhibition of transforming growth factor-β/SMAD signalling by the interferon-γ/STAT pathway. Nature 397: 710-713.
-
(1999)
Nature
, vol.397
, pp. 710-713
-
-
Ulloa, L.1
Doody, J.2
Massagué, J.3
-
215
-
-
8344261349
-
Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis
-
Vega, R.B., Matsuda, K., Oh, J., Barbosa, A.C., Yang, X., Meadows, E., McAnally, J., Pomajzl, C., Shelton, J.M., Richardson, J.A., et al. 2004. Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis. Cell 119: 555-566.
-
(2004)
Cell
, vol.119
, pp. 555-566
-
-
Vega, R.B.1
Matsuda, K.2
Oh, J.3
Barbosa, A.C.4
Yang, X.5
Meadows, E.6
McAnally, J.7
Pomajzl, C.8
Shelton, J.M.9
Richardson, J.A.10
-
216
-
-
0034646674
-
Smad3 and Smad4 mediate transcriptional activation of the human Smad7 promoter by transforming growth factor β
-
von Gersdorff, G., Susztak, K., Rezvani, F., Bitzer, M., Liang, D., and Bottinger, E.P. 2000. Smad3 and Smad4 mediate transcriptional activation of the human Smad7 promoter by transforming growth factor β. J. Biol. Chem. 275: 11320-11326.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 11320-11326
-
-
Von Gersdorff, G.1
Susztak, K.2
Rezvani, F.3
Bitzer, M.4
Liang, D.5
Bottinger, E.P.6
-
217
-
-
0032549806
-
Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo
-
Waldrip, W.R., Bikoff, E.K., Hoodless, P.A., Wrana, J.L., and Robertson, E.J. 1998. Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo. Cell 92: 797-808.
-
(1998)
Cell
, vol.92
, pp. 797-808
-
-
Waldrip, W.R.1
Bikoff, E.K.2
Hoodless, P.A.3
Wrana, J.L.4
Robertson, E.J.5
-
218
-
-
2442492933
-
Smad4 protein stability is regulated by ubiquitin ligase SCF β-TrCP1
-
Wan, M., Tang, Y., Tytler, E.M., Lu, C., Jin, B., Vickers, S.M., Yang, L., Shi, X., and Cao, X. 2004. Smad4 protein stability is regulated by ubiquitin ligase SCF β-TrCP1. J. Biol. Chem. 279: 14484-14487.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 14484-14487
-
-
Wan, M.1
Tang, Y.2
Tytler, E.M.3
Lu, C.4
Jin, B.5
Vickers, S.M.6
Yang, L.7
Shi, X.8
Cao, X.9
-
219
-
-
0000237552
-
Role of PML in cell growth and the retinoic acid pathway
-
Wang, Z.G., Delva, L., Gaboli, M., Rivi, R., Giorgio, M., Cordon-Cardo, C., Grosveld, F., and Pandolfi, P.P. 1998. Role of PML in cell growth and the retinoic acid pathway. Science 279: 1547-1551.
-
(1998)
Science
, vol.279
, pp. 1547-1551
-
-
Wang, Z.G.1
Delva, L.2
Gaboli, M.3
Rivi, R.4
Giorgio, M.5
Cordon-Cardo, C.6
Grosveld, F.7
Pandolfi, P.P.8
-
220
-
-
0034687731
-
Ski represses bone morphogenic protein signaling in Xenopus and mammalian cells
-
Wang, W., Mariani, F.V., Harland, R.M., and Luo, K. 2000. Ski represses bone morphogenic protein signaling in Xenopus and mammalian cells. Proc. Natl. Acad. Sci. 97: 14394-14399.
-
(2000)
Proc. Natl. Acad. Sci.
, vol.97
, pp. 14394-14399
-
-
Wang, W.1
Mariani, F.V.2
Harland, R.M.3
Luo, K.4
-
221
-
-
0034252221
-
Regulation of intracellular dynamics of Smad4 by its leucine-rich nuclear export signal
-
Watanabe, M., Masuyama, N., Fukuda, M., and Nishida, E. 2000. Regulation of intracellular dynamics of Smad4 by its leucine-rich nuclear export signal. EMBO Rep. 1: 176-182.
-
(2000)
EMBO Rep.
, vol.1
, pp. 176-182
-
-
Watanabe, M.1
Masuyama, N.2
Fukuda, M.3
Nishida, E.4
-
222
-
-
0037188473
-
ERK2 enters the nucleus by a carrier-independent mechanism
-
Whitehurst, A.W., Wilsbacher, J.L., You, Y., Luby-Phelps, K., Moore, M.S., and Cobb, M.H. 2002. ERK2 enters the nucleus by a carrier-independent mechanism. Proc. Natl. Acad. Sci. 99: 7496-7501.
-
(2002)
Proc. Natl. Acad. Sci.
, vol.99
, pp. 7496-7501
-
-
Whitehurst, A.W.1
Wilsbacher, J.L.2
You, Y.3
Luby-Phelps, K.4
Moore, M.S.5
Cobb, M.H.6
-
223
-
-
0032529159
-
Smads and early developmental signaling by the TGFβ superfamily
-
Whitman, M. 1998. Smads and early developmental signaling by the TGFβ superfamily. Genes & Dev. 12: 2445-2462.
-
(1998)
Genes & Dev.
, vol.12
, pp. 2445-2462
-
-
Whitman, M.1
-
224
-
-
0033780420
-
Inactivation of smad-transforming growth factor β signaling by Ca(2+)-calmodulin-dependent protein kinase II
-
Wicks, S.J., Lui, S., Abdel-Wahab, N., Mason, R.M., and Chantry, A. 2000. Inactivation of smad-transforming growth factor β signaling by Ca(2+)-calmodulin-dependent protein kinase II. Mol. Cell. Biol. 20: 8103-8111.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 8103-8111
-
-
Wicks, S.J.1
Lui, S.2
Abdel-Wahab, N.3
Mason, R.M.4
Chantry, A.5
-
225
-
-
0030886059
-
Concentration-dependent patterning of the Xenopus ectoderm by BMP4 and its signal transducer Smad1
-
Wilson, P.A., Lagna, G., Suzuki, A., and Hemmati-Brivanlou, A. 1997. Concentration-dependent patterning of the Xenopus ectoderm by BMP4 and its signal transducer Smad1. Development 124: 3177-3184.
-
(1997)
Development
, vol.124
, pp. 3177-3184
-
-
Wilson, P.A.1
Lagna, G.2
Suzuki, A.3
Hemmati-Brivanlou, A.4
-
226
-
-
0031812037
-
Medea is a Drosophila Smad4 homolog that is differentially required to potentiate DPP responses
-
Wisotzkey, R.G., Mehra, A., Sutherland, D.J., Dobens, L.L., Liu, X., Dohrmann, C., Attisano, L., and Raftery, L.A. 1998. Medea is a Drosophila Smad4 homolog that is differentially required to potentiate DPP responses. Development 125: 1433-1445.
-
(1998)
Development
, vol.125
, pp. 1433-1445
-
-
Wisotzkey, R.G.1
Mehra, A.2
Sutherland, D.J.3
Dobens, L.L.4
Liu, X.5
Dohrmann, C.6
Attisano, L.7
Raftery, L.A.8
-
227
-
-
0032979988
-
Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor β
-
Wong, C., Rougier-Chapman, E.M., Frederick, J.P., Datto, M.B., Liberati, N.T., Li, J.M., and Wang, X.F. 1999. Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor β. Mol. Cell. Biol. 19: 1821-1830.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 1821-1830
-
-
Wong, C.1
Rougier-Chapman, E.M.2
Frederick, J.P.3
Datto, M.B.4
Liberati, N.T.5
Li, J.M.6
Wang, X.F.7
-
228
-
-
0033515620
-
A Smad transcriptional corepressor
-
Wotton, D., Lo, R.S., Lee, S., and Massagué, J. 1999a. A Smad transcriptional corepressor. Cell 97: 29-39.
-
(1999)
Cell
, vol.97
, pp. 29-39
-
-
Wotton, D.1
Lo, R.S.2
Lee, S.3
Massagué, J.4
-
229
-
-
0033601272
-
Multiple modes of repression by the Smad transcriptional corepressor TGIF
-
Wotton, D., Lo, R.S., Swaby, L.A., and Massagué, J. 1999b. Multiple modes of repression by the Smad transcriptional corepressor TGIF. J. Biol. Chem. 274: 37105-37110.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 37105-37110
-
-
Wotton, D.1
Lo, R.S.2
Swaby, L.A.3
Massagué, J.4
-
230
-
-
0028170226
-
Mechanism of activation of the TGF-β receptor
-
Wrana, J.L., Attisano, L., Wieser, R., Ventura, F., and Massagué, J. 1994. Mechanism of activation of the TGF-β receptor. Nature 370: 341-347.
-
(1994)
Nature
, vol.370
, pp. 341-347
-
-
Wrana, J.L.1
Attisano, L.2
Wieser, R.3
Ventura, F.4
Massagué, J.5
-
231
-
-
0034614708
-
Structural basis of Smad2 recognition by the Smad anchor for receptor activation
-
Wu, G., Chen, Y.G., Ozdamar, B., Gyuricza, C.A., Chong, P.A., Wrana, J.L., Massagué, J., and Shi, Y. 2000. Structural basis of Smad2 recognition by the Smad anchor for receptor activation. Science 287: 92-97.
-
(2000)
Science
, vol.287
, pp. 92-97
-
-
Wu, G.1
Chen, Y.G.2
Ozdamar, B.3
Gyuricza, C.A.4
Chong, P.A.5
Wrana, J.L.6
Massagué, J.7
Shi, Y.8
-
232
-
-
0035827668
-
Formation of a stable heterodimer between Smad2 and Smad4
-
Wu, J.W., Fairman, R., Penry, J., and Shi, Y. 2001a. Formation of a stable heterodimer between Smad2 and Smad4. J. Biol. Chem. 276: 20688-20694.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 20688-20694
-
-
Wu, J.W.1
Fairman, R.2
Penry, J.3
Shi, Y.4
-
233
-
-
18244362844
-
Crystal structure of a phosphorylated Smad2. Recognition of phosphoserine by the MH2 domain and insights on Smad function in TGF-β signaling
-
Wu, J.W., Hu, M., Chai, J., Seoane, J., Huse, M., Li, C., Rigotti, D.J., Kyin, S., Muir, T.W., Fairman, R., et al. 2001b. Crystal structure of a phosphorylated Smad2. Recognition of phosphoserine by the MH2 domain and insights on Smad function in TGF-β signaling. Mol. Cell 8: 1277-1289.
-
(2001)
Mol. Cell
, vol.8
, pp. 1277-1289
-
-
Wu, J.W.1
Hu, M.2
Chai, J.3
Seoane, J.4
Huse, M.5
Li, C.6
Rigotti, D.J.7
Kyin, S.8
Muir, T.W.9
Fairman, R.10
-
234
-
-
0036848069
-
Structural mechanism of Smad4 recognition by the nuclear oncoprotein Ski: Insights on Ski-mediated repression of TGF-β signaling
-
Wu, J.W., Krawitz, A.R., Chai, J., Li, W., Zhang, F., Luo, K., and Shi, Y. 2002. Structural mechanism of Smad4 recognition by the nuclear oncoprotein Ski: Insights on Ski-mediated repression of TGF-β signaling. Cell 111: 357-367.
-
(2002)
Cell
, vol.111
, pp. 357-367
-
-
Wu, J.W.1
Krawitz, A.R.2
Chai, J.3
Li, W.4
Zhang, F.5
Luo, K.6
Shi, Y.7
-
235
-
-
0035379649
-
Transforming growth factor-β receptor-associated protein 1 is a Smad4 chaperone
-
Wurthner, J.U., Frank, D.B., Felici, A., Green, H.M., Cao, Z., Schneider, M.D., McNally, J.G., Lechleider, R.J., and Roberts, A.B. 2001. Transforming growth factor-β receptor-associated protein 1 is a Smad4 chaperone. J. Biol. Chem. 276: 19495-19502.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 19495-19502
-
-
Wurthner, J.U.1
Frank, D.B.2
Felici, A.3
Green, H.M.4
Cao, Z.5
Schneider, M.D.6
McNally, J.G.7
Lechleider, R.J.8
Roberts, A.B.9
-
236
-
-
0034604343
-
Importin β mediates nuclear translocation of Smad 3
-
Xiao, Z., Liu, X., and Lodish, H.F. 2000. Importin β mediates nuclear translocation of Smad 3. J. Biol. Chem. 275: 23425-23428.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 23425-23428
-
-
Xiao, Z.1
Liu, X.2
Lodish, H.F.3
-
237
-
-
10744224961
-
Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis
-
Xiao, C., Shim, J.M., Kluppel, M., Zhang, S.S., Dong, C., Flavell, R.A., Fu, X.Y., Wrana, J.L., Hogan, B.L., and Ghosh, S. 2003. Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis. Genes & Dev. 17: 2933-2949.
-
(2003)
Genes & Dev.
, vol.17
, pp. 2933-2949
-
-
Xiao, C.1
Shim, J.M.2
Kluppel, M.3
Zhang, S.S.4
Dong, C.5
Flavell, R.A.6
Fu, X.Y.7
Wrana, J.L.8
Hogan, B.L.9
Ghosh, S.10
-
238
-
-
1542284152
-
Nucleocytoplasmic shuttling of signal transducers
-
Xu, L. and Massagué, J. 2004. Nucleocytoplasmic shuttling of signal transducers. Nat. Rev. Mol. Cell Biol. 5: 209-219.
-
(2004)
Nat. Rev. Mol. Cell Biol.
, vol.5
, pp. 209-219
-
-
Xu, L.1
Massagué, J.2
-
239
-
-
0032145411
-
Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to the Drosophila mesoderm
-
Xu, X., Yin, Z., Hudson, J.B., Ferguson, E.L., and Frasch, M. 1998. Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to the Drosophila mesoderm. Genes & Dev. 12: 2354-2370.
-
(1998)
Genes & Dev.
, vol.12
, pp. 2354-2370
-
-
Xu, X.1
Yin, Z.2
Hudson, J.B.3
Ferguson, E.L.4
Frasch, M.5
-
240
-
-
0034253480
-
The nuclear import function of Smad2 is masked by SARA and unmasked by TGFβ-dependent phosphorylation
-
Xu, L., Chen, Y.G., and Massagué, J. 2000. The nuclear import function of Smad2 is masked by SARA and unmasked by TGFβ-dependent phosphorylation. Nat. Cell Biol. 2: 559-562.
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 559-562
-
-
Xu, L.1
Chen, Y.G.2
Massagué, J.3
-
241
-
-
0036670359
-
Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFβ signaling complexes in the cytoplasm and nucleus
-
Xu, L., Kang, Y., Col, S., and Massagué, J. 2002. Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFβ signaling complexes in the cytoplasm and nucleus. Mol. Cell 10: 271-282.
-
(2002)
Mol. Cell
, vol.10
, pp. 271-282
-
-
Xu, L.1
Kang, Y.2
Col, S.3
Massagué, J.4
-
242
-
-
0142211206
-
Distinct domain utilization by Smad3 and Smad4 for nucleoporin interaction and nuclear import
-
Xu, L., Alarcon, C., Col, S., and Massagué, J. 2003. Distinct domain utilization by Smad3 and Smad4 for nucleoporin interaction and nuclear import. J. Biol. Chem. 278: 42569-42577.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 42569-42577
-
-
Xu, L.1
Alarcon, C.2
Col, S.3
Massagué, J.4
-
243
-
-
0033534573
-
Alternatively spliced variant of Smad2 lacking exon 3. Comparison with wild-type Smad2 and Smad3
-
Yagi, K., Goto, D., Hamamoto, T., Takenoshita, S., Kato, M., and Miyazono, K. 1999. Alternatively spliced variant of Smad2 lacking exon 3. Comparison with wild-type Smad2 and Smad3. J. Biol. Chem. 274: 703-709.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 703-709
-
-
Yagi, K.1
Goto, D.2
Hamamoto, T.3
Takenoshita, S.4
Kato, M.5
Miyazono, K.6
-
244
-
-
0034708737
-
The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors
-
Yahata, T., de Caestecker, M.P., Lechleider, R.J., Andriole, S., Roberts, A.B., Isselbacher, K.J., and Shioda, T. 2000. The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors. J. Biol. Chem. 275: 8825-8834.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 8825-8834
-
-
Yahata, T.1
De Caestecker, M.P.2
Lechleider, R.J.3
Andriole, S.4
Roberts, A.B.5
Isselbacher, K.J.6
Shioda, T.7
-
245
-
-
0037007204
-
The rasGAP-binding protein, Dok-1, mediates activin signaling via serine/threonine kinase receptors
-
Yamakawa, N., Tsuchida, K., and Sugino, H. 2002. The rasGAP-binding protein, Dok-1, mediates activin signaling via serine/threonine kinase receptors. EMBO J. 21: 1684-1694.
-
(2002)
EMBO J.
, vol.21
, pp. 1684-1694
-
-
Yamakawa, N.1
Tsuchida, K.2
Sugino, H.3
-
246
-
-
1542285164
-
SUMO promotes HDAC-mediated transcriptional repression
-
Yang, S.H. and Sharrocks, A.D. 2004. SUMO promotes HDAC-mediated transcriptional repression. Mol. Cell 13: 611-617.
-
(2004)
Mol. Cell
, vol.13
, pp. 611-617
-
-
Yang, S.H.1
Sharrocks, A.D.2
-
247
-
-
0032910953
-
β-Catenin can be transported into the nucleus in a Ran-unassisted manner
-
Yokoya, F., Imamoto, N., Tachibana, T., and Yoneda, Y. 1999. β-Catenin can be transported into the nucleus in a Ran-unassisted manner. Mol. Biol. Cell 10: 1119-1131.
-
(1999)
Mol. Biol. Cell
, vol.10
, pp. 1119-1131
-
-
Yokoya, F.1
Imamoto, N.2
Tachibana, T.3
Yoneda, Y.4
-
248
-
-
17744389965
-
Negative regulation of BMP/Smad signaling by Tob in osteoblasts
-
Yoshida, Y., Tanaka, S., Umemori, H., Minowa, O., Usui, M., Ikematsu, N., Hosoda, E., Imamura, T., Kuno, J., Yamashita, T., et al. 2000. Negative regulation of BMP/Smad signaling by Tob in osteoblasts. Cell 103: 1085-1097.
-
(2000)
Cell
, vol.103
, pp. 1085-1097
-
-
Yoshida, Y.1
Tanaka, S.2
Umemori, H.3
Minowa, O.4
Usui, M.5
Ikematsu, N.6
Hosoda, E.7
Imamura, T.8
Kuno, J.9
Yamashita, T.10
-
249
-
-
0347475689
-
Tob proteins enhance inhibitory Smad-receptor interactions to repress BMP signaling
-
Yoshida, Y., von Bubnoff, A., Ikematsu, N., Blitz, I.L., Tsuzuku, J.K., Yoshida, E.H., Umemori, H., Miyazono, K., Yamamoto, T., and Cho, K.W. 2003. Tob proteins enhance inhibitory Smad-receptor interactions to repress BMP signaling. Mech. Dev. 120: 629-637.
-
(2003)
Mech. Dev.
, vol.120
, pp. 629-637
-
-
Yoshida, Y.1
Von Bubnoff, A.2
Ikematsu, N.3
Blitz, I.L.4
Tsuzuku, J.K.5
Yoshida, E.H.6
Umemori, H.7
Miyazono, K.8
Yamamoto, T.9
Cho, K.W.10
-
250
-
-
0035810944
-
Genetic programs of epithelial cell plasticity directed by transforming growth factor-β
-
Zavadil, J., Bitzer, M., Liang, D., Yang, Y.C., Massimi, A., Kneitz, S., Piek, E., and Bottinger, E.P. 2001. Genetic programs of epithelial cell plasticity directed by transforming growth factor-β. Proc. Natl. Acad. Sci. 98: 6686-6691.
-
(2001)
Proc. Natl. Acad. Sci.
, vol.98
, pp. 6686-6691
-
-
Zavadil, J.1
Bitzer, M.2
Liang, D.3
Yang, Y.C.4
Massimi, A.5
Kneitz, S.6
Piek, E.7
Bottinger, E.P.8
-
251
-
-
0032014216
-
Human Smad3 and Smad4 are sequence-specific transcription activators
-
Zawel, L., Dai, J.L., Buckhaults, P., Zhou, S., Kinzler, K.W., Vogelstein, B., and Kern, S.E. 1998. Human Smad3 and Smad4 are sequence-specific transcription activators. Mol. Cell 1: 611-617.
-
(1998)
Mol. Cell
, vol.1
, pp. 611-617
-
-
Zawel, L.1
Dai, J.L.2
Buckhaults, P.3
Zhou, S.4
Kinzler, K.W.5
Vogelstein, B.6
Kern, S.E.7
-
252
-
-
0034595970
-
Transcriptional regulation of the transforming growth factor-β-inducible mouse germ line Ig α constant region gene by functional cooperation of Smad, CREB, and AML family members
-
Zhang, Y. and Derynck, R. 2000. Transcriptional regulation of the transforming growth factor-β-inducible mouse germ line Ig α constant region gene by functional cooperation of Smad, CREB, and AML family members. J. Biol. Chem. 275: 16979-16985.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 16979-16985
-
-
Zhang, Y.1
Derynck, R.2
-
253
-
-
0029786212
-
Receptor-associated Mad homologues synergize as effectors of the TGF-β response
-
Zhang, Y., Feng, X., We, R., and Derynck, R. 1996. Receptor-associated Mad homologues synergize as effectors of the TGF-β response. Nature 383: 168-172.
-
(1996)
Nature
, vol.383
, pp. 168-172
-
-
Zhang, Y.1
Feng, X.2
We, R.3
Derynck, R.4
-
254
-
-
0032572723
-
Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription
-
Zhang, Y., Feng, X.H., and Derynck, R. 1998. Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription. Nature 394: 909-913.
-
(1998)
Nature
, vol.394
, pp. 909-913
-
-
Zhang, Y.1
Feng, X.H.2
Derynck, R.3
-
255
-
-
0033549789
-
A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation
-
Zhu, H., Kavsak, P., Abdollah, S., Wrana, J.L., and Thomsen, G.H. 1999. A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. Nature 400: 687-693.
-
(1999)
Nature
, vol.400
, pp. 687-693
-
-
Zhu, H.1
Kavsak, P.2
Abdollah, S.3
Wrana, J.L.4
Thomsen, G.H.5
|