메뉴 건너뛰기




Volumn 19, Issue 23, 2005, Pages 2783-2810

Smad transcription factors

Author keywords

Signaling; Smad; TGF ; Transcription

Indexed keywords

BETA CATENIN; DNA; KARYOPHERIN BETA; PROTEIN MAD1; SMAD PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA;

EID: 27644494876     PISSN: 08909369     EISSN: 15495477     Source Type: Journal    
DOI: 10.1101/gad.1350705     Document Type: Review
Times cited : (2056)

References (255)
  • 2
    • 0033521032 scopus 로고    scopus 로고
    • c-Ski acts as a transcriptional co-repressor in transforming growth factor-β signaling through interaction with Smads
    • Akiyoshi, S., Inoue, H., Hanai, J., Kusanagi, K., Nemoto, N., Miyazono, K., and Kawabata, M. 1999. c-Ski acts as a transcriptional co-repressor in transforming growth factor-β signaling through interaction with Smads. J. Biol. Chem. 274: 35269-35277.
    • (1999) J. Biol. Chem. , vol.274 , pp. 35269-35277
    • Akiyoshi, S.1    Inoue, H.2    Hanai, J.3    Kusanagi, K.4    Nemoto, N.5    Miyazono, K.6    Kawabata, M.7
  • 3
    • 0035341209 scopus 로고    scopus 로고
    • TGF-β-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation
    • Alliston, T., Choy, L., Ducy, P., Karsenty, G., and Derynck, R. 2001. TGF-β-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation. EMBO J. 20: 2254-2272.
    • (2001) EMBO J. , vol.20 , pp. 2254-2272
    • Alliston, T.1    Choy, L.2    Ducy, P.3    Karsenty, G.4    Derynck, R.5
  • 4
    • 0037204990 scopus 로고    scopus 로고
    • Signal transduction by the TGF-β superfamily
    • Attisano, L. and Wrana, J.L. 2002. Signal transduction by the TGF-β superfamily. Science 296: 1646-1647.
    • (2002) Science , vol.296 , pp. 1646-1647
    • Attisano, L.1    Wrana, J.L.2
  • 5
    • 2942650916 scopus 로고    scopus 로고
    • In vivo convergence of BMP and MAPK signaling pathways: Impact of differential Smad1 phosphorylation on development and homeostasis
    • Aubin, J., Davy, A., and Soriano, P. 2004. In vivo convergence of BMP and MAPK signaling pathways: Impact of differential Smad1 phosphorylation on development and homeostasis. Genes & Dev. 18: 1482-1494.
    • (2004) Genes & Dev. , vol.18 , pp. 1482-1494
    • Aubin, J.1    Davy, A.2    Soriano, P.3
  • 6
    • 0034708801 scopus 로고    scopus 로고
    • Smad6 as a transcriptional corepressor
    • Bai, S., Shi, X., Yang, X., and Cao, X. 2000. Smad6 as a transcriptional corepressor. J. Biol. Chem. 275: 8267-8270.
    • (2000) J. Biol. Chem. , vol.275 , pp. 8267-8270
    • Bai, S.1    Shi, X.2    Yang, X.3    Cao, X.4
  • 8
    • 4444223733 scopus 로고    scopus 로고
    • Itch E3 ligase-mediated regulation of TGF-β signaling by modulating smad2 phosphorylation
    • Bai, Y., Yang, C., Hu, K., Elly, C., and Liu, Y.C. 2004. Itch E3 ligase-mediated regulation of TGF-β signaling by modulating smad2 phosphorylation. Mol. Cell 15: 825-831.
    • (2004) Mol. Cell , vol.15 , pp. 825-831
    • Bai, Y.1    Yang, C.2    Hu, K.3    Elly, C.4    Liu, Y.C.5
  • 10
    • 0030480969 scopus 로고    scopus 로고
    • The CBP co-activator is a histone acetyltransferase
    • Bannister, A.J. and Kouzarides, T. 1996. The CBP co-activator is a histone acetyltransferase. Nature 384: 641-643.
    • (1996) Nature , vol.384 , pp. 641-643
    • Bannister, A.J.1    Kouzarides, T.2
  • 11
    • 0034616910 scopus 로고    scopus 로고
    • Structural basis for the interaction between FxFG nucleoporin repeats and importin-β in nuclear trafficking
    • Bayliss, R., Littlewood, T., and Stewart, M. 2000. Structural basis for the interaction between FxFG nucleoporin repeats and importin-β in nuclear trafficking. Cell 102: 99-108.
    • (2000) Cell , vol.102 , pp. 99-108
    • Bayliss, R.1    Littlewood, T.2    Stewart, M.3
  • 12
    • 0043192745 scopus 로고    scopus 로고
    • GATA- and Smad1-dependent enhancers in the Smad7 gene differentially interpret bone morphogenetic protein concentrations
    • Benchabane, H. and Wrana, J.L. 2003. GATA- and Smad1-dependent enhancers in the Smad7 gene differentially interpret bone morphogenetic protein concentrations. Mol. Cell. Biol. 23: 6646-6661.
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 6646-6661
    • Benchabane, H.1    Wrana, J.L.2
  • 13
    • 0030799236 scopus 로고    scopus 로고
    • Mice lacking the ski proto-oncogene have defects in neurulation, craniofacial, patterning, and skeletal muscle development
    • Berk, M., Desai, S.Y., Heyman, H.C., and Colmenares, C. 1997. Mice lacking the ski proto-oncogene have defects in neurulation, craniofacial, patterning, and skeletal muscle development. Genes & Dev. 11: 2029-2039.
    • (1997) Genes & Dev. , vol.11 , pp. 2029-2039
    • Berk, M.1    Desai, S.Y.2    Heyman, H.C.3    Colmenares, C.4
  • 14
    • 0032529532 scopus 로고    scopus 로고
    • Smad7 inhibits mesoderm formation and promotes neural cell fate in Xenopus embryos
    • Bhushan, A., Chen, Y., and Vale, W. 1998. Smad7 inhibits mesoderm formation and promotes neural cell fate in Xenopus embryos. Dev. Biol. 200: 260-268.
    • (1998) Dev. Biol. , vol.200 , pp. 260-268
    • Bhushan, A.1    Chen, Y.2    Vale, W.3
  • 16
    • 0034976149 scopus 로고    scopus 로고
    • TGF-β induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation
    • Bonni, S., Wang, H.R., Causing, C.G., Kavsak, P., Stroschein, S.L., Luo, K., and Wrana, J.L. 2001. TGF-β induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation. Nat. Cell Biol. 3: 587-595.
    • (2001) Nat. Cell Biol. , vol.3 , pp. 587-595
    • Bonni, S.1    Wang, H.R.2    Causing, C.G.3    Kavsak, P.4    Stroschein, S.L.5    Luo, K.6    Wrana, J.L.7
  • 17
    • 0036333146 scopus 로고    scopus 로고
    • A changing morphogen gradient is interpreted by continuous transduction flow
    • Bourillot, P.Y., Garrett, N., and Gurdon, J.B. 2002. A changing morphogen gradient is interpreted by continuous transduction flow. Development 129: 2167-2180.
    • (2002) Development , vol.129 , pp. 2167-2180
    • Bourillot, P.Y.1    Garrett, N.2    Gurdon, J.B.3
  • 18
    • 0034666152 scopus 로고    scopus 로고
    • Efficient TGF-β induction of the Smad7 gene requires cooperation between AP-1, Sp1, and Smad proteins on the mouse Smad7 promoter
    • Brodin, G., Ahgren, A., ten Dijke, P., Heldin, C.H., and Heuchel, R. 2000. Efficient TGF-β induction of the Smad7 gene requires cooperation between AP-1, Sp1, and Smad proteins on the mouse Smad7 promoter. J. Biol. Chem. 275: 29023-29030.
    • (2000) J. Biol. Chem. , vol.275 , pp. 29023-29030
    • Brodin, G.1    Ahgren, A.2    Ten Dijke, P.3    Heldin, C.H.4    Heuchel, R.5
  • 19
    • 1642402120 scopus 로고    scopus 로고
    • The cardiac determination factor, Nkx2-5, is activated by mutual cofactors GATA-4 and Smad1/4 via a novel upstream enhancer
    • Brown III, C.O., Chi, X., Garcia-Gras, E., Shirai, M., Feng, X.H., and Schwartz, R.J. 2004. The cardiac determination factor, Nkx2-5, is activated by mutual cofactors GATA-4 and Smad1/4 via a novel upstream enhancer. J. Biol. Chem. 279: 10659-10669.
    • (2004) J. Biol. Chem. , vol.279 , pp. 10659-10669
    • Brown III, C.O.1    Chi, X.2    Garcia-Gras, E.3    Shirai, M.4    Feng, X.H.5    Schwartz, R.J.6
  • 20
    • 0032900499 scopus 로고    scopus 로고
    • The Drosophila activin receptor baboon signals through dSmad2 and controls cell proliferation but not patterning during larval development
    • Brummel, T., Abdollah, S., Haerry, T.E., Shimell, M.J., Merriam, J., Raftery, L., Wrana, J.L., and O'Connor, M.B. 1999. The Drosophila activin receptor baboon signals through dSmad2 and controls cell proliferation but not patterning during larval development. Genes & Dev. 13: 98-111.
    • (1999) Genes & Dev. , vol.13 , pp. 98-111
    • Brummel, T.1    Abdollah, S.2    Haerry, T.E.3    Shimell, M.J.4    Merriam, J.5    Raftery, L.6    Wrana, J.L.7    O'Connor, M.B.8
  • 22
    • 0032101098 scopus 로고    scopus 로고
    • Xenopus Smad7 inhibits both the activin and BMP pathways and acts as a neural inducer
    • Casellas, R. and Brivanlou, A.H. 1998. Xenopus Smad7 inhibits both the activin and BMP pathways and acts as a neural inducer. Dev. Biol. 198: 1-12.
    • (1998) Dev. Biol. , vol.198 , pp. 1-12
    • Casellas, R.1    Brivanlou, A.H.2
  • 25
    • 0038820062 scopus 로고    scopus 로고
    • Features of a Smad3 MH1-DNA complex. Roles of water and zinc in DNA binding
    • Chai, J., Wu, J.W., Yan, N., Massagué, J., Pavletich, N.P., and Shi, Y. 2003. Features of a Smad3 MH1-DNA complex. Roles of water and zinc in DNA binding. J. Biol. Chem. 278: 20327-20331.
    • (2003) J. Biol. Chem. , vol.278 , pp. 20327-20331
    • Chai, J.1    Wu, J.W.2    Yan, N.3    Massagué, J.4    Pavletich, N.P.5    Shi, Y.6
  • 26
    • 15444380557 scopus 로고    scopus 로고
    • Daxx mediates the small ubiquitin-like modifier-dependent transcriptional repression of Smad4
    • Chang, C.C., Lin, D.Y., Fang, H.I., Chen, R.H., and Shih, H.M. 2005. Daxx mediates the small ubiquitin-like modifier-dependent transcriptional repression of Smad4. J. Biol. Chem. 280: 10164-10173.
    • (2005) J. Biol. Chem. , vol.280 , pp. 10164-10173
    • Chang, C.C.1    Lin, D.Y.2    Fang, H.I.3    Chen, R.H.4    Shih, H.M.5
  • 27
    • 0029802485 scopus 로고    scopus 로고
    • A transcriptional partner for MAD proteins in TGF-β signalling
    • Chen, X., Rubock, M.J., and Whitman, M. 1996. A transcriptional partner for MAD proteins in TGF-β signalling. Nature 383: 691-696.
    • (1996) Nature , vol.383 , pp. 691-696
    • Chen, X.1    Rubock, M.J.2    Whitman, M.3
  • 29
    • 0030926004 scopus 로고    scopus 로고
    • Mechanism of TGFβ receptor inhibition by FKBP12
    • Chen, Y.G., Liu, F., and Massagué, J. 1997. Mechanism of TGFβ receptor inhibition by FKBP12. EMBO J. 16: 3866-3876.
    • (1997) EMBO J. , vol.16 , pp. 3866-3876
    • Chen, Y.G.1    Liu, F.2    Massagué, J.3
  • 30
    • 0035970035 scopus 로고    scopus 로고
    • Defective repression of c-myc in breast cancer cells: A loss at the core of the transforming growth factor β growth arrest program
    • Chen, C.R., Kang, Y., and Massagué, J. 2001. Defective repression of c-myc in breast cancer cells: A loss at the core of the transforming growth factor β growth arrest program. Proc. Natl. Acad. Sci. 98: 992-1009.
    • (2001) Proc. Natl. Acad. Sci. , vol.98 , pp. 992-1009
    • Chen, C.R.1    Kang, Y.2    Massagué, J.3
  • 31
    • 0037067653 scopus 로고    scopus 로고
    • E2F4/5 and p107 as Smad cofactors linking the TGFβ receptor to c-myc repression
    • Chen, C.R., Kang, Y., Siegel, P.M., and Massagué, J. 2002. E2F4/5 and p107 as Smad cofactors linking the TGFβ receptor to c-myc repression. Cell 110: 19-32.
    • (2002) Cell , vol.110 , pp. 19-32
    • Chen, C.R.1    Kang, Y.2    Siegel, P.M.3    Massagué, J.4
  • 33
    • 4444249320 scopus 로고    scopus 로고
    • Differential requirements for Smad4 in TGFβ-dependent patterning of the early mouse embryo
    • Chu, G.C., Dunn, N.R., Anderson, D.C., Oxburgh, L., and Robertson, E.J. 2004. Differential requirements for Smad4 in TGFβ-dependent patterning of the early mouse embryo. Development 131: 3501-3512.
    • (2004) Development , vol.131 , pp. 3501-3512
    • Chu, G.C.1    Dunn, N.R.2    Anderson, D.C.3    Oxburgh, L.4    Robertson, E.J.5
  • 34
    • 0025948485 scopus 로고
    • Activation of the c-ski oncogene by overexpression
    • Colmenares, C., Sutrave, P., Hughes, S.H., and Stavnezer, E. 1991. Activation of the c-ski oncogene by overexpression. J. Virol. 65: 4929-4935.
    • (1991) J. Virol. , vol.65 , pp. 4929-4935
    • Colmenares, C.1    Sutrave, P.2    Hughes, S.H.3    Stavnezer, E.4
  • 35
    • 0036334452 scopus 로고    scopus 로고
    • Loss of the SKI proto-oncogene in individuals affected with 1p36 deletion syndrome is predicted by strain-dependent defects in Ski-/- mice
    • Colmenares, C., Heilstedt, H.A., Shaffer, L.G., Schwartz, S., Berk, M., Murray, J.C., and Stavnezer, E. 2002. Loss of the SKI proto-oncogene in individuals affected with 1p36 deletion syndrome is predicted by strain-dependent defects in Ski-/- mice. Nat. Genet. 30: 106-109.
    • (2002) Nat. Genet. , vol.30 , pp. 106-109
    • Colmenares, C.1    Heilstedt, H.A.2    Shaffer, L.G.3    Schwartz, S.4    Berk, M.5    Murray, J.C.6    Stavnezer, E.7
  • 36
    • 0038274163 scopus 로고    scopus 로고
    • Links between tumor suppressors: p53 is required for TGF-β gene responses by cooperating with Smads
    • Cordenonsi, M., Dupont, S., Maretto, S., Insinga, A., Imbriano, C., and Piccolo, S. 2003. Links between tumor suppressors: p53 is required for TGF-β gene responses by cooperating with Smads. Cell 113: 301-314.
    • (2003) Cell , vol.113 , pp. 301-314
    • Cordenonsi, M.1    Dupont, S.2    Maretto, S.3    Insinga, A.4    Imbriano, C.5    Piccolo, S.6
  • 38
    • 0032567487 scopus 로고    scopus 로고
    • Identification of STRAP, a novel WD domain protein in transforming growth factor-β signaling
    • Datta, P.K., Chytil, A., Gorska, A.E., and Moses, H.L. 1998. Identification of STRAP, a novel WD domain protein in transforming growth factor-β signaling. J. Biol. Chem. 273: 34671-34674.
    • (1998) J. Biol. Chem. , vol.273 , pp. 34671-34674
    • Datta, P.K.1    Chytil, A.2    Gorska, A.E.3    Moses, H.L.4
  • 40
    • 0034612231 scopus 로고    scopus 로고
    • Transforming growth factor β-inducible independent binding of SMAD to the Smad7 promoter
    • Denissova, N.G., Pouponnot, C., Long, J., He, D., and Liu, F. 2000. Transforming growth factor β-inducible independent binding of SMAD to the Smad7 promoter. Proc. Natl. Acad. Sci. 97: 6397-6402.
    • (2000) Proc. Natl. Acad. Sci. , vol.97 , pp. 6397-6402
    • Denissova, N.G.1    Pouponnot, C.2    Long, J.3    He, D.4    Liu, F.5
  • 41
    • 0142104985 scopus 로고    scopus 로고
    • Smad-dependent and Smad-independent pathways in TGF-β family signalling
    • Derynck, R. and Zhang, Y.E. 2003. Smad-dependent and Smad-independent pathways in TGF-β family signalling. Nature 425: 577-584.
    • (2003) Nature , vol.425 , pp. 577-584
    • Derynck, R.1    Zhang, Y.E.2
  • 42
    • 0034785348 scopus 로고    scopus 로고
    • TGF-β signaling in tumor suppression and cancer progression
    • Derynck, R., Akhurst, R.J., and Balmain, A. 2001. TGF-β signaling in tumor suppression and cancer progression. Nat. Genet. 29: 117-129.
    • (2001) Nat. Genet. , vol.29 , pp. 117-129
    • Derynck, R.1    Akhurst, R.J.2    Balmain, A.3
  • 43
    • 0032135131 scopus 로고    scopus 로고
    • SUMO-1 modification of IκBα inhibits NF-κB activation
    • Desterro, J.M., Rodriguez, M.S., and Hay, R.T. 1998. SUMO-1 modification of IκBα inhibits NF-κB activation. Mol. Cell 2: 233-239.
    • (1998) Mol. Cell , vol.2 , pp. 233-239
    • Desterro, J.M.1    Rodriguez, M.S.2    Hay, R.T.3
  • 44
    • 0037598870 scopus 로고    scopus 로고
    • Distinct endocytic pathways regulate TGF-β receptor signalling and turnover
    • Di Guglielmo, G.M., Le Roy, C., Goodfellow, A.F., and Wrana, J.L. 2003. Distinct endocytic pathways regulate TGF-β receptor signalling and turnover. Nat. Cell Biol. 5: 410-421.
    • (2003) Nat. Cell Biol. , vol.5 , pp. 410-421
    • Di Guglielmo, G.M.1    Le Roy, C.2    Goodfellow, A.F.3    Wrana, J.L.4
  • 45
    • 11844271440 scopus 로고    scopus 로고
    • Mice exclusively expressing the short isoform of Smad2 develop normally and are viable and fertile
    • Dunn, N.R., Koonce, C.H., Anderson, D.C., Islam, A., Bikoff, E.K., and Robertson, E.J. 2005. Mice exclusively expressing the short isoform of Smad2 develop normally and are viable and fertile. Genes & Dev. 19: 152-163.
    • (2005) Genes & Dev. , vol.19 , pp. 152-163
    • Dunn, N.R.1    Koonce, C.H.2    Anderson, D.C.3    Islam, A.4    Bikoff, E.K.5    Robertson, E.J.6
  • 46
    • 17044365440 scopus 로고    scopus 로고
    • Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase
    • Dupont, S., Zacchigna, L., Cordenonsi, M., Soligo, S., Adorno, M., Rugge, M., and Piccolo, S. 2005. Germ-layer specification and control of cell growth by Ectodermin, a Smad4 ubiquitin ligase. Cell 121: 87-99.
    • (2005) Cell , vol.121 , pp. 87-99
    • Dupont, S.1    Zacchigna, L.2    Cordenonsi, M.3    Soligo, S.4    Adorno, M.5    Rugge, M.6    Piccolo, S.7
  • 47
    • 0032524323 scopus 로고    scopus 로고
    • The interpretation of position in a morphogen gradient as revealed by occupancy of activin receptors
    • Dyson, S. and Gurdon, J.B. 1998. The interpretation of position in a morphogen gradient as revealed by occupancy of activin receptors. Cell 93: 557-568.
    • (1998) Cell , vol.93 , pp. 557-568
    • Dyson, S.1    Gurdon, J.B.2
  • 48
    • 0035848835 scopus 로고    scopus 로고
    • Induction of the mammalian node requires Arkadia function in the extraembryonic lineages
    • Episkopou, V., Arkell, R., Timmons, P.M., Walsh, J.J., Andrew, R.L., and Swan, D. 2001. Induction of the mammalian node requires Arkadia function in the extraembryonic lineages. Nature 410: 825-830.
    • (2001) Nature , vol.410 , pp. 825-830
    • Episkopou, V.1    Arkell, R.2    Timmons, P.M.3    Walsh, J.J.4    Andrew, R.L.5    Swan, D.6
  • 49
    • 0141995069 scopus 로고    scopus 로고
    • The nuclear pore complex: Nucleocytoplasmic transport and beyond
    • Fahrenkrog, B. and Aebi, U. 2003. The nuclear pore complex: Nucleocytoplasmic transport and beyond. Nat. Rev. Mol. Cell Biol. 4: 757-766.
    • (2003) Nat. Rev. Mol. Cell Biol. , vol.4 , pp. 757-766
    • Fahrenkrog, B.1    Aebi, U.2
  • 50
    • 0042738094 scopus 로고    scopus 로고
    • TLP, a novel modulator of TGF-β signaling, has opposite effects on Smad2- and Smad3-dependent signaling
    • Felici, A., Wurthner, J.U., Parks, W.T., Giam, L.R., Reiss, M., Karpova, T.S., McNally, J.G., and Roberts, A.B. 2003. TLP, a novel modulator of TGF-β signaling, has opposite effects on Smad2- and Smad3-dependent signaling. EMBO J. 22: 4465-4477.
    • (2003) EMBO J. , vol.22 , pp. 4465-4477
    • Felici, A.1    Wurthner, J.U.2    Parks, W.T.3    Giam, L.R.4    Reiss, M.5    Karpova, T.S.6    McNally, J.G.7    Roberts, A.B.8
  • 51
    • 0032528236 scopus 로고    scopus 로고
    • The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for Smad3 in TGF-β-induced transcriptional activation
    • Feng, X.-H., Zhang, Y., Wu, R.-Y., and Derynck, R. 1998. The tumor suppressor Smad4/DPC4 and transcriptional adaptor CBP/p300 are coactivators for Smad3 in TGF-β-induced transcriptional activation. Genes & Dev. 12: 2153-2163.
    • (1998) Genes & Dev. , vol.12 , pp. 2153-2163
    • Feng, X.-H.1    Zhang, Y.2    Wu, R.-Y.3    Derynck, R.4
  • 52
    • 0034596993 scopus 로고    scopus 로고
    • Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-β
    • Feng, X.H., Lin, X., and Derynck, R. 2000. Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-β. EMBO J. 19: 5178-5193.
    • (2000) EMBO J. , vol.19 , pp. 5178-5193
    • Feng, X.H.1    Lin, X.2    Derynck, R.3
  • 54
    • 0030924190 scopus 로고    scopus 로고
    • CRM1 is an export receptor for leucine-rich nuclear export signals
    • Fornerod, M., Ohno, M., Yoshida, M., and Mattaj, I.Q. 1997. CRM1 is an export receptor for leucine-rich nuclear export signals. Cell 90: 1051-1060.
    • (1997) Cell , vol.90 , pp. 1051-1060
    • Fornerod, M.1    Ohno, M.2    Yoshida, M.3    Mattaj, I.Q.4
  • 55
    • 1542314236 scopus 로고    scopus 로고
    • Transforming growth factor β-mediated transcriptional repression of c-myc is dependent on direct binding of Smad3 to a novel repressive Smad binding element
    • Frederick, J.P., Liberati, N.R., Waddell, D.S., Shi, Y., and Wang, X.F. 2004. Transforming growth factor β-mediated transcriptional repression of c-myc is dependent on direct binding of Smad3 to a novel repressive Smad binding element. Mol. Cell. Biol. 24: 2546-2559.
    • (2004) Mol. Cell. Biol. , vol.24 , pp. 2546-2559
    • Frederick, J.P.1    Liberati, N.R.2    Waddell, D.S.3    Shi, Y.4    Wang, X.F.5
  • 56
    • 0034767430 scopus 로고    scopus 로고
    • Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins
    • Fukuchi, M., Imamura, T., Chiba, T., Ebisawa, T., Kawabata, M., Tanaka, K., and Miyazono, K. 2001. Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins. Mol. Biol. Cell 12: 1431-1443.
    • (2001) Mol. Biol. Cell , vol.12 , pp. 1431-1443
    • Fukuchi, M.1    Imamura, T.2    Chiba, T.3    Ebisawa, T.4    Kawabata, M.5    Tanaka, K.6    Miyazono, K.7
  • 59
    • 0031727693 scopus 로고    scopus 로고
    • Gene expression screening in Xenopus identifies molecular pathways, predicts gene function and provides a global view of embryonic patterning
    • Gawantka, V., Pollet, N., Delius, H., Vingron, M., Pfister, R., Nitsch, R., Blumenstock, C., and Niehrs, C. 1998. Gene expression screening in Xenopus identifies molecular pathways, predicts gene function and provides a global view of embryonic patterning. Mech. Dev. 77: 95-141.
    • (1998) Mech. Dev. , vol.77 , pp. 95-141
    • Gawantka, V.1    Pollet, N.2    Delius, H.3    Vingron, M.4    Pfister, R.5    Nitsch, R.6    Blumenstock, C.7    Niehrs, C.8
  • 60
    • 0034007925 scopus 로고    scopus 로고
    • Homeodomain and winged-helix transcription factors recruit activated Smads to distinct promoter elements via a common Smad interaction motif
    • Germain, S., Howell, M., Esslemont, G.M., and Hill, C.S. 2000. Homeodomain and winged-helix transcription factors recruit activated Smads to distinct promoter elements via a common Smad interaction motif. Genes & Dev. 14: 435-451.
    • (2000) Genes & Dev. , vol.14 , pp. 435-451
    • Germain, S.1    Howell, M.2    Esslemont, G.M.3    Hill, C.S.4
  • 61
    • 0033279841 scopus 로고    scopus 로고
    • Transport between the cell nucleus and the cytoplasm
    • Gorlich, D. and Kutay, U. 1999. Transport between the cell nucleus and the cytoplasm. Annu. Rev. Cell Dev. Biol. 15: 607-660.
    • (1999) Annu. Rev. Cell Dev. Biol. , vol.15 , pp. 607-660
    • Gorlich, D.1    Kutay, U.2
  • 62
    • 0024518943 scopus 로고
    • Loss of competence in amphibian induction can take place in single nondividing cells
    • Grainger, R.M. and Gurdon, J.B. 1989. Loss of competence in amphibian induction can take place in single nondividing cells. Proc. Natl. Acad. Sci. 86: 1900-1904.
    • (1989) Proc. Natl. Acad. Sci. , vol.86 , pp. 1900-1904
    • Grainger, R.M.1    Gurdon, J.B.2
  • 63
    • 0036301992 scopus 로고    scopus 로고
    • Nuclear exclusion of Smad2 is a mechanism leading to loss of competence
    • Grimm, O.H. and Gurdon, J.B. 2002. Nuclear exclusion of Smad2 is a mechanism leading to loss of competence. Nat. Cell Biol. 4: 519-522.
    • (2002) Nat. Cell Biol. , vol.4 , pp. 519-522
    • Grimm, O.H.1    Gurdon, J.B.2
  • 65
    • 0036753547 scopus 로고    scopus 로고
    • Control of Smad7 stability by competition between acetylation and ubiquitination
    • Gronroos, E., Hellman, U., Heldin, C.H., and Ericsson, J. 2002. Control of Smad7 stability by competition between acetylation and ubiquitination. Mol. Cell 10: 483-493.
    • (2002) Mol. Cell , vol.10 , pp. 483-493
    • Gronroos, E.1    Hellman, U.2    Heldin, C.H.3    Ericsson, J.4
  • 66
    • 0039844411 scopus 로고    scopus 로고
    • Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Cα promoter
    • Hanai, J., Chen, L.F., Kanno, T., Ohtani-Fujita, N., Kim, W.Y., Guo, W.H., Imamura, T., Ishidou, Y., Fukuchi, M., Shi, M.J., et al. 1999. Interaction and functional cooperation of PEBP2/CBF with Smads. Synergistic induction of the immunoglobulin germline Cα promoter. J. Biol. Chem. 274: 31577-31582.
    • (1999) J. Biol. Chem. , vol.274 , pp. 31577-31582
    • Hanai, J.1    Chen, L.F.2    Kanno, T.3    Ohtani-Fujita, N.4    Kim, W.Y.5    Guo, W.H.6    Imamura, T.7    Ishidou, Y.8    Fukuchi, M.9    Shi, M.J.10
  • 67
    • 0030825516 scopus 로고    scopus 로고
    • Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4
    • Hata, A., Lo, R.S., Wotton, D., Lagna, G., and Massagué, J. 1997. Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4. Nature 388: 82-87.
    • (1997) Nature , vol.388 , pp. 82-87
    • Hata, A.1    Lo, R.S.2    Wotton, D.3    Lagna, G.4    Massagué, J.5
  • 68
    • 0031964859 scopus 로고    scopus 로고
    • Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor
    • Hata, A., Lagna, G., Massagué, J., and Hemmati-Brivanlou, A. 1998. Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor. Genes & Dev. 12: 186-197.
    • (1998) Genes & Dev. , vol.12 , pp. 186-197
    • Hata, A.1    Lagna, G.2    Massagué, J.3    Hemmati-Brivanlou, A.4
  • 69
    • 0034695506 scopus 로고    scopus 로고
    • OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways
    • Hata, A., Seoane, J., Lagna, G., Montalvo, E., Hemmati-Brivanlou, A., and Massagué, J. 2000. OAZ uses distinct DNA- and protein-binding zinc fingers in separate BMP-Smad and Olf signaling pathways. Cell 100: 229-240.
    • (2000) Cell , vol.100 , pp. 229-240
    • Hata, A.1    Seoane, J.2    Lagna, G.3    Montalvo, E.4    Hemmati-Brivanlou, A.5    Massagué, J.6
  • 73
    • 0043234699 scopus 로고    scopus 로고
    • The transforming activity of Ski and SnoN is dependent on their ability to repress the activity of Smad proteins
    • He, J., Tegen, S.B., Krawitz, A.R., Martin, G.S., and Luo, K. 2003. The transforming activity of Ski and SnoN is dependent on their ability to repress the activity of Smad proteins. J. Biol. Chem. 278: 30540-30547.
    • (2003) J. Biol. Chem. , vol.278 , pp. 30540-30547
    • He, J.1    Tegen, S.B.2    Krawitz, A.R.3    Martin, G.S.4    Luo, K.5
  • 76
    • 0035355473 scopus 로고    scopus 로고
    • The adaptor molecule Disabled-2 links the transforming growth factor β receptors to the Smad pathway
    • Hocevar, B.A., Smine, A., Xu, X.X., and Howe, P.H. 2001. The adaptor molecule Disabled-2 links the transforming growth factor β receptors to the Smad pathway. EMBO J. 20: 2789-2801.
    • (2001) EMBO J. , vol.20 , pp. 2789-2801
    • Hocevar, B.A.1    Smine, A.2    Xu, X.X.3    Howe, P.H.4
  • 77
    • 0029737070 scopus 로고    scopus 로고
    • Bone morphogenetic proteins: Multifunctional regulators of vertebrate development
    • Hogan, B.L. 1996. Bone morphogenetic proteins: Multifunctional regulators of vertebrate development. Genes & Dev. 10: 1580-1594.
    • (1996) Genes & Dev. , vol.10 , pp. 1580-1594
    • Hogan, B.L.1
  • 79
    • 13444262316 scopus 로고    scopus 로고
    • Smad1, β-catenin and Tcf4 associate in a molecular complex with the Myc promoter in dysplastic renal tissue and cooperate to control Myc transcription
    • Hu, M.C. and Rosenblum, N.D. 2005. Smad1, β-catenin and Tcf4 associate in a molecular complex with the Myc promoter in dysplastic renal tissue and cooperate to control Myc transcription. Development 132: 215-225.
    • (2005) Development , vol.132 , pp. 215-225
    • Hu, M.C.1    Rosenblum, N.D.2
  • 80
    • 0034721771 scopus 로고    scopus 로고
    • Synergism between transcription factors TFE3 and Smad3 in transforming growth factor-β-induced transcription of the Smad7 gene
    • Hua, X., Miller, Z.A., Benchabane, H., Wrana, J.L., and Lodish, H.F. 2000. Synergism between transcription factors TFE3 and Smad3 in transforming growth factor-β-induced transcription of the Smad7 gene. J. Biol. Chem. 275: 33205-33208.
    • (2000) J. Biol. Chem. , vol.275 , pp. 33205-33208
    • Hua, X.1    Miller, Z.A.2    Benchabane, H.3    Wrana, J.L.4    Lodish, H.F.5
  • 81
    • 0033524943 scopus 로고    scopus 로고
    • Crystal structure of the cytoplasmic domain of the type I TGF β receptor in complex with FKBP12
    • Huse, M., Chen, Y.G., Massagué, J., and Kuriyan, J. 1999. Crystal structure of the cytoplasmic domain of the type I TGF β receptor in complex with FKBP12. Cell 96: 425-436.
    • (1999) Cell , vol.96 , pp. 425-436
    • Huse, M.1    Chen, Y.G.2    Massagué, J.3    Kuriyan, J.4
  • 82
    • 0034796457 scopus 로고    scopus 로고
    • The TGF β receptor activation process: An inhibitor- to substrate-binding switch
    • Huse, M., Muir, T.W., Xu, L., Chen, Y.G., Kuriyan, J., and Massagué, J. 2001. The TGF β receptor activation process: An inhibitor- to substrate-binding switch. Mol. Cell 8: 671-682.
    • (2001) Mol. Cell , vol.8 , pp. 671-682
    • Huse, M.1    Muir, T.W.2    Xu, L.3    Chen, Y.G.4    Kuriyan, J.5    Massagué, J.6
  • 83
    • 0345491607 scopus 로고    scopus 로고
    • Drosophila TGIF proteins are transcriptional activators
    • Hyman, C.A., Bartholin, L., Newfeld, S.J., and Wotton, D. 2003. Drosophila TGIF proteins are transcriptional activators. Mol. Cell. Biol. 23: 9262-9274.
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 9262-9274
    • Hyman, C.A.1    Bartholin, L.2    Newfeld, S.J.3    Wotton, D.4
  • 84
    • 0030978315 scopus 로고    scopus 로고
    • Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-β in cells lacking the CDK inhibitor p15
    • Iavarone, A. and Massagué, J. 1997. Repression of the CDK activator Cdc25A and cell-cycle arrest by cytokine TGF-β in cells lacking the CDK inhibitor p15. Nature 387: 417-422.
    • (1997) Nature , vol.387 , pp. 417-422
    • Iavarone, A.1    Massagué, J.2
  • 85
    • 0032933352 scopus 로고    scopus 로고
    • E2F and histone deacetylase mediate transforming growth factor β repression of cdc25A during keratinocyte cell cycle arrest
    • -. 1999. E2F and histone deacetylase mediate transforming growth factor β repression of cdc25A during keratinocyte cell cycle arrest. Mol. Cell. Biol. 19: 916-922.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 916-922
  • 87
    • 0034675276 scopus 로고    scopus 로고
    • Amplification and overexpression of TGIF2, a novel homeobox gene of the TALE superclass, in ovarian cancer cell lines
    • Imoto, I., Pimkhaokham, A., Watanabe, T., Saito-Ohara, F., Soeda, E., and Inazawa, J. 2000. Amplification and overexpression of TGIF2, a novel homeobox gene of the TALE superclass, in ovarian cancer cell lines. Biochem. Biophys. Res. Commun. 276: 264-270.
    • (2000) Biochem. Biophys. Res. Commun. , vol.276 , pp. 264-270
    • Imoto, I.1    Pimkhaokham, A.2    Watanabe, T.3    Saito-Ohara, F.4    Soeda, E.5    Inazawa, J.6
  • 88
    • 0037185010 scopus 로고    scopus 로고
    • Stoichiometry of active smad-transcription factor complexes on DNA
    • Inman, G.J. and Hill, C.S. 2002. Stoichiometry of active smad-transcription factor complexes on DNA. J. Biol. Chem. 277: 51008-51016.
    • (2002) J. Biol. Chem. , vol.277 , pp. 51008-51016
    • Inman, G.J.1    Hill, C.S.2
  • 89
    • 0036670339 scopus 로고    scopus 로고
    • Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-β receptor activity
    • Inman, G.J., Nicolas, F.J., and Hill, C.S. 2002. Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-β receptor activity. Mol. Cell 10: 283-294.
    • (2002) Mol. Cell , vol.10 , pp. 283-294
    • Inman, G.J.1    Nicolas, F.J.2    Hill, C.S.3
  • 90
    • 0034093738 scopus 로고    scopus 로고
    • Smad6 is a Smad1/5-induced smad inhibitor. Characterization of bone morphogenetic protein-responsive element in the mouse Smad6 promoter
    • Ishida, W., Hamamoto, T., Kusanagi, K., Yagi, K., Kawabata, M., Takehara, K., Sampath, T.K., Kato, M., and Miyazono, K. 2000. Smad6 is a Smad1/5-induced smad inhibitor. Characterization of bone morphogenetic protein-responsive element in the mouse Smad6 promoter. J. Biol. Chem. 275: 6075-6079.
    • (2000) J. Biol. Chem. , vol.275 , pp. 6075-6079
    • Ishida, W.1    Hamamoto, T.2    Kusanagi, K.3    Yagi, K.4    Kawabata, M.5    Takehara, K.6    Sampath, T.K.7    Kato, M.8    Miyazono, K.9
  • 91
    • 0032544594 scopus 로고    scopus 로고
    • Smad7 is an activin-inducible inhibitor of activin-induced growth arrest and apoptosis in mouse B cells
    • Ishisaki, A., Yamato, K., Nakao, A., Nonaka, K., Ohguchi, M., ten Dijke, P., and Nishihara, T. 1998. Smad7 is an activin-inducible inhibitor of activin-induced growth arrest and apoptosis in mouse B cells. J. Biol. Chem. 273: 24293-24296.
    • (1998) J. Biol. Chem. , vol.273 , pp. 24293-24296
    • Ishisaki, A.1    Yamato, K.2    Nakao, A.3    Nonaka, K.4    Ohguchi, M.5    Ten Dijke, P.6    Nishihara, T.7
  • 93
    • 0034326828 scopus 로고    scopus 로고
    • The transcriptional co-activator P/CAF potentiates TGF-β/Smad signaling
    • Itoh, S., Ericsson, J., Nishikawa, J., Heldin, C.H., and ten Dijke, P. 2000. The transcriptional co-activator P/CAF potentiates TGF-β/Smad signaling. Nucleic Acids Res. 28: 4291-4298.
    • (2000) Nucleic Acids Res. , vol.28 , pp. 4291-4298
    • Itoh, S.1    Ericsson, J.2    Nishikawa, J.3    Heldin, C.H.4    Ten Dijke, P.5
  • 94
    • 0035353203 scopus 로고    scopus 로고
    • The corepressor CtBP interacts with Evi-1 to repress transforming growth factor β signaling
    • Izutsu, K., Kurokawa, M., Imai, Y., Maki, K., Mitani, K., and Hirai, H. 2001. The corepressor CtBP interacts with Evi-1 to repress transforming growth factor β signaling. Blood 97: 2815-2822.
    • (2001) Blood , vol.97 , pp. 2815-2822
    • Izutsu, K.1    Kurokawa, M.2    Imai, Y.3    Maki, K.4    Mitani, K.5    Hirai, H.6
  • 95
    • 1942534004 scopus 로고    scopus 로고
    • Regulation of the TGFβ signalling pathway by ubiquitin-mediated degradation
    • Izzi, L. and Attisano, L. 2004. Regulation of the TGFβ signalling pathway by ubiquitin-mediated degradation. Oncogene 23: 2071-2078.
    • (2004) Oncogene , vol.23 , pp. 2071-2078
    • Izzi, L.1    Attisano, L.2
  • 96
    • 0034041537 scopus 로고    scopus 로고
    • Nuclear targeting signal recognition: A key control point in nuclear transport?
    • Jans, D.A., Xiao, C.Y., and Lam, M.H. 2000. Nuclear targeting signal recognition: A key control point in nuclear transport? Bioessays 22: 532-544.
    • (2000) Bioessays , vol.22 , pp. 532-544
    • Jans, D.A.1    Xiao, C.Y.2    Lam, M.H.3
  • 97
    • 0034731334 scopus 로고    scopus 로고
    • Distinct oligomeric states of SMAD proteins in the transforming growth factor-β pathway
    • Jayaraman, L. and Massagué, J. 2000. Distinct oligomeric states of SMAD proteins in the transforming growth factor-β pathway. J. Biol. Chem. 275: 40710-40717.
    • (2000) J. Biol. Chem. , vol.275 , pp. 40710-40717
    • Jayaraman, L.1    Massagué, J.2
  • 98
    • 3943099375 scopus 로고    scopus 로고
    • Protein modification by SUMO
    • Johnson, E.S. 2004. Protein modification by SUMO. Annu. Rev. Biochem. 73: 355-382.
    • (2004) Annu. Rev. Biochem. , vol.73 , pp. 355-382
    • Johnson, E.S.1
  • 100
    • 0037113990 scopus 로고    scopus 로고
    • Differential modulation of androgen receptor-mediated transactivation by Smad3 and tumor suppressor Smad4
    • Kang, H.Y., Huang, K.E., Chang, S.Y., Ma, W.L., Lin, W.J., and Chang, C. 2002. Differential modulation of androgen receptor-mediated transactivation by Smad3 and tumor suppressor Smad4. J. Biol. Chem. 277: 43749-43756.
    • (2002) J. Biol. Chem. , vol.277 , pp. 43749-43756
    • Kang, H.Y.1    Huang, K.E.2    Chang, S.Y.3    Ma, W.L.4    Lin, W.J.5    Chang, C.6
  • 101
    • 0038369998 scopus 로고    scopus 로고
    • A self-enabling TGF response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells
    • Kang, Y., Chen, C.R., and Massagué, J. 2003. A self-enabling TGF response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells. Mol. Cell 11: 915-926.
    • (2003) Mol. Cell , vol.11 , pp. 915-926
    • Kang, Y.1    Chen, C.R.2    Massagué, J.3
  • 102
    • 23044448510 scopus 로고    scopus 로고
    • Repression of Runx2 function by TGF-β through recruitment of class II histone deacetylases by Smad3
    • Kang, J.S., Alliston, T., Delston, R., and Derynck, R. 2005. Repression of Runx2 function by TGF-β through recruitment of class II histone deacetylases by Smad3. EMBO J. 24: 2543-2555.
    • (2005) EMBO J. , vol.24 , pp. 2543-2555
    • Kang, J.S.1    Alliston, T.2    Delston, R.3    Derynck, R.4
  • 104
    • 1842457724 scopus 로고    scopus 로고
    • Transcriptional regulation of BMP4 synexpression in transgenic Xenopus
    • Karaulanov, E., Knochel, W., and Niehrs, C. 2004. Transcriptional regulation of BMP4 synexpression in transgenic Xenopus. EMBO J. 23: 844-856.
    • (2004) EMBO J. , vol.23 , pp. 844-856
    • Karaulanov, E.1    Knochel, W.2    Niehrs, C.3
  • 105
    • 0037043739 scopus 로고    scopus 로고
    • A component of the ARC/Mediator complex required for TGF β/Nodal signalling
    • Kato, Y., Habas, R., Katsuyama, Y., Naar, A.M., and He, X. 2002. A component of the ARC/Mediator complex required for TGF β/Nodal signalling. Nature 418: 641-646.
    • (2002) Nature , vol.418 , pp. 641-646
    • Kato, Y.1    Habas, R.2    Katsuyama, Y.3    Naar, A.M.4    He, X.5
  • 106
    • 0034517389 scopus 로고    scopus 로고
    • Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF β receptor for degradation
    • Kavsak, P., Rasmussen, R.K., Causing, C.G., Bonni, S., Zhu, H., Thomsen, G.H., and Wrana, J.L. 2000. Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF β receptor for degradation. Mol. Cell 6: 1365-1375.
    • (2000) Mol. Cell , vol.6 , pp. 1365-1375
    • Kavsak, P.1    Rasmussen, R.K.2    Causing, C.G.3    Bonni, S.4    Zhu, H.5    Thomsen, G.H.6    Wrana, J.L.7
  • 107
    • 0242552528 scopus 로고    scopus 로고
    • Smad-dependent recruitment of a histone deacetylase/Sin3A complex modulates the bone morphogenetic protein-dependent transcriptional repressor activity of Nkx3.2
    • Kim, D.W. and Lassar, A.B. 2003. Smad-dependent recruitment of a histone deacetylase/Sin3A complex modulates the bone morphogenetic protein-dependent transcriptional repressor activity of Nkx3.2. Mol. Cell. Biol. 23: 8704-8717.
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 8704-8717
    • Kim, D.W.1    Lassar, A.B.2
  • 108
    • 0030872367 scopus 로고    scopus 로고
    • Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic
    • Kim, J., Johnson, K., Chen, H.J., Carroll, S., and Laughon, A. 1997. Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic. Nature 388: 304-308.
    • (1997) Nature , vol.388 , pp. 304-308
    • Kim, J.1    Johnson, K.2    Chen, H.J.3    Carroll, S.4    Laughon, A.5
  • 110
    • 0035947673 scopus 로고    scopus 로고
    • Repression of dpp targets by binding of brinker to mad sites
    • Kirkpatrick, H., Johnson, K., and Laughon, A. 2001. Repression of dpp targets by binding of brinker to mad sites. J. Biol. Chem. 276: 18216-18222.
    • (2001) J. Biol. Chem. , vol.276 , pp. 18216-18222
    • Kirkpatrick, H.1    Johnson, K.2    Laughon, A.3
  • 112
    • 0037085441 scopus 로고    scopus 로고
    • Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter
    • Korchynskyi, O. and ten Dijke, P. 2002. Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter. J. Biol. Chem. 277: 4883-4891.
    • (2002) J. Biol. Chem. , vol.277 , pp. 4883-4891
    • Korchynskyi, O.1    Ten Dijke, P.2
  • 113
    • 0030773834 scopus 로고    scopus 로고
    • Opposing BMP and EGF signalling pathway converge on the TGFβ family mediator Smad1
    • Kretzschmar, M., Doody, J., and Massagué, J. 1997. Opposing BMP and EGF signalling pathway converge on the TGFβ family mediator Smad1. Nature 389: 618-622.
    • (1997) Nature , vol.389 , pp. 618-622
    • Kretzschmar, M.1    Doody, J.2    Massagué, J.3
  • 114
    • 0033106484 scopus 로고    scopus 로고
    • A mechanism of repression of TGF-β/Smad signaling by oncogenic Ras
    • Kretzschmar, M., Doody, J., Timokhina, I., and Massagué, J. 1999. A mechanism of repression of TGF-β/Smad signaling by oncogenic Ras. Genes & Dev. 13: 804-816.
    • (1999) Genes & Dev. , vol.13 , pp. 804-816
    • Kretzschmar, M.1    Doody, J.2    Timokhina, I.3    Massagué, J.4
  • 115
    • 0035167095 scopus 로고    scopus 로고
    • Transforming growth factor-β induces nuclear import of Smad3 in an importin-β1 and Ran-dependent manner
    • Kurisaki, A., Kose, S., Yoneda, Y., Heldin, C.H., and Moustakas, A. 2001. Transforming growth factor-β induces nuclear import of Smad3 in an importin-β1 and Ran-dependent manner. Mol. Biol. Cell 12: 1079-1091.
    • (2001) Mol. Biol. Cell , vol.12 , pp. 1079-1091
    • Kurisaki, A.1    Kose, S.2    Yoneda, Y.3    Heldin, C.H.4    Moustakas, A.5
  • 117
    • 0042867243 scopus 로고    scopus 로고
    • Sumoylation of Smad4, the common Smad mediator of transforming growth factor-β family signaling
    • Lee, P.S., Chang, C., Liu, D., and Derynck, R. 2003. Sumoylation of Smad4, the common Smad mediator of transforming growth factor-β family signaling. J. Biol. Chem. 278: 27853-27863.
    • (2003) J. Biol. Chem. , vol.278 , pp. 27853-27863
    • Lee, P.S.1    Chang, C.2    Liu, D.3    Derynck, R.4
  • 118
    • 0031944290 scopus 로고    scopus 로고
    • Regulation of immune responses by TGF-β
    • Letterio, J.J. and Roberts, A.B. 1998. Regulation of immune responses by TGF-β. Annu. Rev. Immunol. 16: 137-161.
    • (1998) Annu. Rev. Immunol. , vol.16 , pp. 137-161
    • Letterio, J.J.1    Roberts, A.B.2
  • 119
    • 2542489214 scopus 로고    scopus 로고
    • Regulation of Smad4 Sumoylation and transforming growth factor-β signaling by protein inhibitor of activated STAT1
    • Liang, M., Melchior, F., Feng, X.H., and Lin, X. 2004. Regulation of Smad4 Sumoylation and transforming growth factor-β signaling by protein inhibitor of activated STAT1. J. Biol. Chem. 279: 22857-22865.
    • (2004) J. Biol. Chem. , vol.279 , pp. 22857-22865
    • Liang, M.1    Melchior, F.2    Feng, X.H.3    Lin, X.4
  • 120
    • 0037090906 scopus 로고    scopus 로고
    • Cardiac-specific activity of an Nkx2-5 enhancer requires an evolutionarily conserved Smad binding site
    • Lien, C.L., McAnally, J., Richardson, J.A., and Olson, E.N. 2002. Cardiac-specific activity of an Nkx2-5 enhancer requires an evolutionarily conserved Smad binding site. Dev. Biol. 244: 257-266.
    • (2002) Dev. Biol. , vol.244 , pp. 257-266
    • Lien, C.L.1    McAnally, J.2    Richardson, J.A.3    Olson, E.N.4
  • 121
    • 0041731797 scopus 로고    scopus 로고
    • SUMO-1/Ubc9 promotes nuclear accumulation and metabolic stability of tumor suppressor Smad4
    • Lin, X., Liang, M., Liang, Y.Y., Brunicardi, F.C., and Feng, X.H. 2003a. SUMO-1/Ubc9 promotes nuclear accumulation and metabolic stability of tumor suppressor Smad4. J. Biol. Chem. 278: 31043-31048.
    • (2003) J. Biol. Chem. , vol.278 , pp. 31043-31048
    • Lin, X.1    Liang, M.2    Liang, Y.Y.3    Brunicardi, F.C.4    Feng, X.H.5
  • 122
    • 0037805684 scopus 로고    scopus 로고
    • Activation of transforming growth factor-β signaling by SUMO-1 modification of tumor suppressor Smad4/DPC4
    • Lin, X., Liang, M., Liang, Y.Y., Brunicardi, F.C., Melchior, F., and Feng, X.H. 2003b. Activation of transforming growth factor-β signaling by SUMO-1 modification of tumor suppressor Smad4/DPC4. J. Biol. Chem. 278: 18714-18719.
    • (2003) J. Biol. Chem. , vol.278 , pp. 18714-18719
    • Lin, X.1    Liang, M.2    Liang, Y.Y.3    Brunicardi, F.C.4    Melchior, F.5    Feng, X.H.6
  • 123
    • 0344629431 scopus 로고    scopus 로고
    • Smad6 recruits transcription corepressor CtBP to repress bone morphogenetic protein-induced transcription
    • Lin, X., Liang, Y.Y., Sun, B., Liang, M., Shi, Y., Brunicardi, F.C., and Feng, X.H. 2003c. Smad6 recruits transcription corepressor CtBP to repress bone morphogenetic protein-induced transcription. Mol. Cell. Biol. 23: 9081-9093.
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 9081-9093
    • Lin, X.1    Liang, Y.Y.2    Sun, B.3    Liang, M.4    Shi, Y.5    Brunicardi, F.C.6    Feng, X.H.7
  • 124
    • 4544256756 scopus 로고    scopus 로고
    • Cytoplasmic PML function in TGF-β signalling
    • Lin, H.K., Bergmann, S., and Pandolfi, P.P. 2004. Cytoplasmic PML function in TGF-β signalling. Nature 431: 205-211.
    • (2004) Nature , vol.431 , pp. 205-211
    • Lin, H.K.1    Bergmann, S.2    Pandolfi, P.P.3
  • 125
  • 126
    • 0030690337 scopus 로고    scopus 로고
    • Dual role of the Smad4/DPC4 tumor suppressor in TGFβ-inducible transcriptional complexes
    • Liu, F., Pouponnot, C., and Massagué, J. 1997. Dual role of the Smad4/DPC4 tumor suppressor in TGFβ-inducible transcriptional complexes. Genes & Dev. 11: 3157-3167.
    • (1997) Genes & Dev. , vol.11 , pp. 3157-3167
    • Liu, F.1    Pouponnot, C.2    Massagué, J.3
  • 127
    • 0035890328 scopus 로고    scopus 로고
    • TGF-β inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3
    • Liu, D., Black, B.L., and Derynck, R. 2001. TGF-β inhibits muscle differentiation through functional repression of myogenic transcription factors by Smad3. Genes & Dev. 15: 2950-2966.
    • (2001) Genes & Dev. , vol.15 , pp. 2950-2966
    • Liu, D.1    Black, B.L.2    Derynck, R.3
  • 128
    • 2342514242 scopus 로고    scopus 로고
    • TGF-β-activated Smad3 represses MEF2-dependent transcription in myogenic differentiation
    • Liu, D., Kang, J.S., and Derynck, R. 2004. TGF-β-activated Smad3 represses MEF2-dependent transcription in myogenic differentiation. EMBO J. 23: 1557-1566.
    • (2004) EMBO J. , vol.23 , pp. 1557-1566
    • Liu, D.1    Kang, J.S.2    Derynck, R.3
  • 129
    • 0033257926 scopus 로고    scopus 로고
    • Ubiquitin-dependent degradation of TGF-β-activated Smad2
    • Lo, R.S. and Massagué, J. 1999. Ubiquitin-dependent degradation of TGF-β-activated Smad2. Nat. Cell Biol. 1: 472-478.
    • (1999) Nat. Cell Biol. , vol.1 , pp. 472-478
    • Lo, R.S.1    Massagué, J.2
  • 130
    • 1842844308 scopus 로고    scopus 로고
    • Repression of Smad4 transcriptional activity by SUMO modification
    • Long, J., Wang, G., He, D., and Liu, F. 2004. Repression of Smad4 transcriptional activity by SUMO modification. Biochem. J. 379: 23-29.
    • (2004) Biochem. J. , vol.379 , pp. 23-29
    • Long, J.1    Wang, G.2    He, D.3    Liu, F.4
  • 131
    • 0036479133 scopus 로고    scopus 로고
    • Direct binding of Smad1 and Smad4 to two distinct motifs mediates bone morphogenetic protein-specific transcriptional activation of Id1 gene
    • Lopez-Rovira, T., Chalaux, E., Massagué, J., Rosa, J.L., and Ventura, F. 2002. Direct binding of Smad1 and Smad4 to two distinct motifs mediates bone morphogenetic protein-specific transcriptional activation of Id1 gene. J. Biol. Chem. 277: 3176-3185.
    • (2002) J. Biol. Chem. , vol.277 , pp. 3176-3185
    • Lopez-Rovira, T.1    Chalaux, E.2    Massagué, J.3    Rosa, J.L.4    Ventura, F.5
  • 132
    • 0030048617 scopus 로고    scopus 로고
    • Molecular analysis of Evi1, a zinc finger oncogene involved in myeloid leukemia
    • Lopingco, M.C. and Perkins, A.S. 1996. Molecular analysis of Evi1, a zinc finger oncogene involved in myeloid leukemia. Curr. Top. Microbiol. Immunol. 211: 211-222.
    • (1996) Curr. Top. Microbiol. Immunol. , vol.211 , pp. 211-222
    • Lopingco, M.C.1    Perkins, A.S.2
  • 133
    • 0033200361 scopus 로고    scopus 로고
    • The Ski oncoprotein interacts with the Smad proteins to repress TGFβ signaling
    • Luo, K., Stroschein, S.L., Wang, W., Chen, D., Martens, E., Zhou, S., and Zhou, Q. 1999. The Ski oncoprotein interacts with the Smad proteins to repress TGFβ signaling. Genes & Dev. 13: 2196-2206.
    • (1999) Genes & Dev. , vol.13 , pp. 2196-2206
    • Luo, K.1    Stroschein, S.L.2    Wang, W.3    Chen, D.4    Martens, E.5    Zhou, S.6    Zhou, Q.7
  • 134
    • 0032475884 scopus 로고    scopus 로고
    • Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2
    • Macias-Silva, M., Hoodless, P.A., Tang, S.J., Buchwald, M., and Wrana, J.L. 1998. Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2. J. Biol. Chem. 273: 25628-25636.
    • (1998) J. Biol. Chem. , vol.273 , pp. 25628-25636
    • Macias-Silva, M.1    Hoodless, P.A.2    Tang, S.J.3    Buchwald, M.4    Wrana, J.L.5
  • 135
    • 0035053298 scopus 로고    scopus 로고
    • Transgenic analysis of the Smad family of TGF-β signal transducers in Drosophila melanogaster suggests new roles and new interactions between family members
    • Marquez, R.M., Singer, M.A., Takaesu, N.T., Waldrip, W.R., Kraytsberg, Y., and Newfeld, S.J. 2001. Transgenic analysis of the Smad family of TGF-β signal transducers in Drosophila melanogaster suggests new roles and new interactions between family members. Genetics 157: 1639-1648.
    • (2001) Genetics , vol.157 , pp. 1639-1648
    • Marquez, R.M.1    Singer, M.A.2    Takaesu, N.T.3    Waldrip, W.R.4    Kraytsberg, Y.5    Newfeld, S.J.6
  • 136
    • 0242620396 scopus 로고    scopus 로고
    • Schnurri mediates Dpp-dependent repression of brinker transcription
    • Marty, T., Muller, B., Basler, K., and Affolter, M. 2000. Schnurri mediates Dpp-dependent repression of brinker transcription. Nat. Cell Biol. 2: 745-749.
    • (2000) Nat. Cell Biol. , vol.2 , pp. 745-749
    • Marty, T.1    Muller, B.2    Basler, K.3    Affolter, M.4
  • 137
    • 0031685620 scopus 로고    scopus 로고
    • TGFβ signal transduction
    • Massagué, J. 1998. TGF signal transduction. Annu. Rev. Biochem. 67: 753-791.
    • (1998) Annu. Rev. Biochem. , vol.67 , pp. 753-791
    • Massagué, J.1
  • 138
    • 0347991862 scopus 로고    scopus 로고
    • Integration of Smad and MAPK pathways: A link and a linker revisited
    • -. 2003. Integration of Smad and MAPK pathways: A link and a linker revisited. Genes & Dev. 17: 2993-2997.
    • (2003) Genes & Dev. , vol.17 , pp. 2993-2997
  • 139
    • 9244239811 scopus 로고    scopus 로고
    • G1 cell-cycle control and cancer
    • -. 2004. G1 cell-cycle control and cancer. Nature 432: 298-306.
    • (2004) Nature , vol.432 , pp. 298-306
  • 140
    • 0034654497 scopus 로고    scopus 로고
    • Controlling TGF-β signaling
    • Massagué, J. and Chen, Y.G. 2000. Controlling TGF-β signaling. Genes & Dev. 14: 627-644.
    • (2000) Genes & Dev. , vol.14 , pp. 627-644
    • Massagué, J.1    Chen, Y.G.2
  • 141
    • 0034678908 scopus 로고    scopus 로고
    • Transcriptional control by the TGF-β/Smad signaling system
    • Massagué, J. and Wotton, D. 2000. Transcriptional control by the TGF-β/Smad signaling system. EMBO J. 19: 1745-1754.
    • (2000) EMBO J. , vol.19 , pp. 1745-1754
    • Massagué, J.1    Wotton, D.2
  • 142
    • 0034644472 scopus 로고    scopus 로고
    • TGFβ signaling in growth control, cancer, and heritable disorders
    • Massagué, J., Blain, S.W., and Lo, R.S. 2000. TGFβ signaling in growth control, cancer, and heritable disorders. Cell 103: 295-309.
    • (2000) Cell , vol.103 , pp. 295-309
    • Massagué, J.1    Blain, S.W.2    Lo, R.S.3
  • 143
    • 3142546336 scopus 로고    scopus 로고
    • Cyclin-dependent kinases regulate the antiproliferative function of Smads
    • Matsuura, I., Denissova, N.G., Wang, G., He, D., Long, J., and Liu, F. 2004. Cyclin-dependent kinases regulate the antiproliferative function of Smads. Nature 430: 226-231.
    • (2004) Nature , vol.430 , pp. 226-231
    • Matsuura, I.1    Denissova, N.G.2    Wang, G.3    He, D.4    Long, J.5    Liu, F.6
  • 144
    • 0031707505 scopus 로고    scopus 로고
    • Nucleocytoplasmic transport: The soluble phase
    • Mattaj, I.W. and Englmeier, L. 1998. Nucleocytoplasmic transport: The soluble phase. Annu. Rev. Biochem. 67: 265-306.
    • (1998) Annu. Rev. Biochem. , vol.67 , pp. 265-306
    • Mattaj, I.W.1    Englmeier, L.2
  • 145
  • 146
    • 0034671905 scopus 로고    scopus 로고
    • The interaction of the carboxyl terminus-binding protein with the Smad corepressor TGIF is disrupted by a holoprosencephaly mutation in TGIF
    • Melhuish, T.A. and Wotton, D. 2000. The interaction of the carboxyl terminus-binding protein with the Smad corepressor TGIF is disrupted by a holoprosencephaly mutation in TGIF. J. Biol. Chem. 275: 39762-39766.
    • (2000) J. Biol. Chem. , vol.275 , pp. 39762-39766
    • Melhuish, T.A.1    Wotton, D.2
  • 147
    • 0035943703 scopus 로고    scopus 로고
    • TGIF2 interacts with histone deacetylase 1 and represses transcription
    • Melhuish, T.A., Gallo, C.M., and Wotton, D. 2001. TGIF2 interacts with histone deacetylase 1 and represses transcription. J. Biol. Chem. 276: 32109-32114.
    • (2001) J. Biol. Chem. , vol.276 , pp. 32109-32114
    • Melhuish, T.A.1    Gallo, C.M.2    Wotton, D.3
  • 149
    • 20444439172 scopus 로고    scopus 로고
    • Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases
    • Moren, A., Imamura, T., Miyazono, K., Heldin, C.H., and Moustakas, A. 2005. Degradation of the tumor suppressor Smad4 by WW and HECT domain ubiquitin ligases. J. Biol. Chem. 280: 22115-22123.
    • (2005) J. Biol. Chem. , vol.280 , pp. 22115-22123
    • Moren, A.1    Imamura, T.2    Miyazono, K.3    Heldin, C.H.4    Moustakas, A.5
  • 150
    • 0242417167 scopus 로고    scopus 로고
    • Conversion of an extracellular Dpp/BMP morphogen gradient into an inverse transcriptional gradient
    • Muller, B., Hartmann, B., Pyrowolakis, G., Affolter, M., and Basler, K. 2003. Conversion of an extracellular Dpp/BMP morphogen gradient into an inverse transcriptional gradient. Cell 113: 221-233.
    • (2003) Cell , vol.113 , pp. 221-233
    • Muller, B.1    Hartmann, B.2    Pyrowolakis, G.3    Affolter, M.4    Basler, K.5
  • 151
    • 0038107486 scopus 로고    scopus 로고
    • Cooperative inhibition of bone morphogenetic protein signaling by Smurf1 and inhibitory Smads
    • Murakami, G., Watabe, T., Takaoka, K., Miyazono, K., and Imamura, T. 2003. Cooperative inhibition of bone morphogenetic protein signaling by Smurf1 and inhibitory Smads. Mol. Biol. Cell 14: 2809-2817.
    • (2003) Mol. Biol. Cell , vol.14 , pp. 2809-2817
    • Murakami, G.1    Watabe, T.2    Takaoka, K.3    Miyazono, K.4    Imamura, T.5
  • 155
    • 0035848854 scopus 로고    scopus 로고
    • Arkadia enhances nodal-related signalling to induce mesendoderm
    • Niederlander, C., Walsh, J.J., Episkopou, V., and Jones, C.M. 2001. Arkadia enhances nodal-related signalling to induce mesendoderm. Nature 410: 830-834.
    • (2001) Nature , vol.410 , pp. 830-834
    • Niederlander, C.1    Walsh, J.J.2    Episkopou, V.3    Jones, C.M.4
  • 156
    • 0037007643 scopus 로고    scopus 로고
    • Modular feedback
    • Niehrs, C. and Meinhardt, H. 2002. Modular feedback. Nature 417: 35-36.
    • (2002) Nature , vol.417 , pp. 35-36
    • Niehrs, C.1    Meinhardt, H.2
  • 157
    • 0033518256 scopus 로고    scopus 로고
    • Synexpression groups in eukaryotes
    • Niehrs, C. and Pollet, N. 1999. Synexpression groups in eukaryotes. Nature 402: 483-487.
    • (1999) Nature , vol.402 , pp. 483-487
    • Niehrs, C.1    Pollet, N.2
  • 158
    • 0034677494 scopus 로고    scopus 로고
    • Interaction between Wnt and TGF-β signalling pathways during formation of Spemann's organizer
    • Nishita, M., Hashimoto, M.K., Ogata, S., Laurent, M.N., Ueno, N., Shibuya, H., and Cho, K.W. 2000. Interaction between Wnt and TGF-β signalling pathways during formation of Spemann's organizer. Nature 403: 781-785.
    • (2000) Nature , vol.403 , pp. 781-785
    • Nishita, M.1    Hashimoto, M.K.2    Ogata, S.3    Laurent, M.N.4    Ueno, N.5    Shibuya, H.6    Cho, K.W.7
  • 159
    • 0033557497 scopus 로고    scopus 로고
    • Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor
    • Nomura, T., Khan, M.M., Kaul, S.C., Dong, H.D., Wadhwa, R., Colmenares, C., Kohno, I., and Ishii, S. 1999. Ski is a component of the histone deacetylase complex required for transcriptional repression by Mad and thyroid hormone receptor. Genes & Dev. 13: 412-423.
    • (1999) Genes & Dev. , vol.13 , pp. 412-423
    • Nomura, T.1    Khan, M.M.2    Kaul, S.C.3    Dong, H.D.4    Wadhwa, R.5    Colmenares, C.6    Kohno, I.7    Ishii, S.8
  • 160
    • 0030606239 scopus 로고    scopus 로고
    • The transcriptional coactivators p300 and CBP are histone acetyltransferases
    • Ogryzko, V.V., Schiltz, R.L., Russanova, V., Howard, B.H., and Nakatani, Y. 1996. The transcriptional coactivators p300 and CBP are histone acetyltransferases. Cell 87: 953-959.
    • (1996) Cell , vol.87 , pp. 953-959
    • Ogryzko, V.V.1    Schiltz, R.L.2    Russanova, V.3    Howard, B.H.4    Nakatani, Y.5
  • 161
    • 0347065367 scopus 로고    scopus 로고
    • Transforming growth factor-β-mediated signaling via the p38 MAP kinase pathway activates Smad-dependent transcription through SUMO-1 modification of Smad4
    • Ohshima, T. and Shimotohno, K. 2003. Transforming growth factor-β-mediated signaling via the p38 MAP kinase pathway activates Smad-dependent transcription through SUMO-1 modification of Smad4. J. Biol. Chem. 278: 50833-50842.
    • (2003) J. Biol. Chem. , vol.278 , pp. 50833-50842
    • Ohshima, T.1    Shimotohno, K.2
  • 163
    • 0030579203 scopus 로고    scopus 로고
    • TGF-β receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis
    • Oshima, M., Oshima, H., and Taketo, M.M. 1996. TGF-β receptor type II deficiency results in defects of yolk sac hematopoiesis and vasculogenesis. Dev. Biol. 179: 297-302.
    • (1996) Dev. Biol. , vol.179 , pp. 297-302
    • Oshima, M.1    Oshima, H.2    Taketo, M.M.3
  • 164
    • 14844364701 scopus 로고    scopus 로고
    • Regulation of the polarity protein Par6 by TGFβ receptors controls epithelial cell plasticity
    • Ozdamar, B., Bose, R., Barrios-Rodiles, M., Wang, H.R., Zhang, Y., and Wrana, J.L. 2005. Regulation of the polarity protein Par6 by TGFβ receptors controls epithelial cell plasticity. Science 307: 1603-1609.
    • (2005) Science , vol.307 , pp. 1603-1609
    • Ozdamar, B.1    Bose, R.2    Barrios-Rodiles, M.3    Wang, H.R.4    Zhang, Y.5    Wrana, J.L.6
  • 165
    • 18144411595 scopus 로고    scopus 로고
    • The integral inner nuclear membrane protein MAN1 physically interacts with the R-Smad proteins to repress signaling by the transforming growth factor-β superfamily of cytokines
    • Pan, D., Estevez-Salmeron, L.D., Stroschein, S.L., Zhu, X., He, J., Zhou, S., and Luo, K. 2005. The integral inner nuclear membrane protein MAN1 physically interacts with the R-Smad proteins to repress signaling by the transforming growth factor-β superfamily of cytokines. J. Biol. Chem. 280: 15992-16001.
    • (2005) J. Biol. Chem. , vol.280 , pp. 15992-16001
    • Pan, D.1    Estevez-Salmeron, L.D.2    Stroschein, S.L.3    Zhu, X.4    He, J.5    Zhou, S.6    Luo, K.7
  • 167
    • 0034703083 scopus 로고    scopus 로고
    • Role of Smad proteins and transcription factor Sp1 in p21(Waf1/Cip1) regulation by transforming growth factor-β
    • Pardali, K., Kurisaki, A., Moren, A., ten Dijke, P., Kardassis, D., and Moustakas, A. 2000. Role of Smad proteins and transcription factor Sp1 in p21(Waf1/Cip1) regulation by transforming growth factor-β. J. Biol. Chem. 275: 29244-29256.
    • (2000) J. Biol. Chem. , vol.275 , pp. 29244-29256
    • Pardali, K.1    Kurisaki, A.2    Moren, A.3    Ten Dijke, P.4    Kardassis, D.5    Moustakas, A.6
  • 168
    • 0346594337 scopus 로고    scopus 로고
    • Integration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural induction
    • Pera, E.M., Ikeda, A., Eivers, E., and De Robertis, E.M. 2003. Integration of IGF, FGF, and anti-BMP signals via Smad1 phosphorylation in neural induction. Genes & Dev. 17: 3023-3028.
    • (2003) Genes & Dev. , vol.17 , pp. 3023-3028
    • Pera, E.M.1    Ikeda, A.2    Eivers, E.3    De Robertis, E.M.4
  • 169
    • 0034460336 scopus 로고    scopus 로고
    • Transforming growth factor β-independent shuttling of Smad4 between the cytoplasm and nucleus
    • Pierreux, C.E., Nicolas, F.J., and Hill, C.S. 2000. Transforming growth factor β-independent shuttling of Smad4 between the cytoplasm and nucleus. Mol. Cell. Biol. 20: 9041-9054.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 9041-9054
    • Pierreux, C.E.1    Nicolas, F.J.2    Hill, C.S.3
  • 170
    • 0035489160 scopus 로고    scopus 로고
    • The DSmurf ubiquitin-protein ligase restricts BMP signaling spatially and temporally during Drosophila embryogenesis
    • Podos, S.D., Hanson, K.K., Wang, Y.C., and Ferguson, E.L. 2001. The DSmurf ubiquitin-protein ligase restricts BMP signaling spatially and temporally during Drosophila embryogenesis. Dev. Cell 1: 567-578.
    • (2001) Dev. Cell , vol.1 , pp. 567-578
    • Podos, S.D.1    Hanson, K.K.2    Wang, Y.C.3    Ferguson, E.L.4
  • 171
    • 0032483493 scopus 로고    scopus 로고
    • Physical and functional interactions of Smads and p300/CBP
    • Pouponnot, C., Jayaraman, L., and Massagué, J. 1998. Physical and functional interactions of Smads and p300/CBP. J. Biol. Chem. 273: 22865-22868.
    • (1998) J. Biol. Chem. , vol.273 , pp. 22865-22868
    • Pouponnot, C.1    Jayaraman, L.2    Massagué, J.3
  • 173
    • 0033564526 scopus 로고    scopus 로고
    • TGF-β family signal transduction in Drosophila development: From Mad to Smads
    • Raftery, L.A. and Sutherland, D.J. 1999. TGF-β family signal transduction in Drosophila development: From Mad to Smads. Dev. Biol. 210: 251-268.
    • (1999) Dev. Biol. , vol.210 , pp. 251-268
    • Raftery, L.A.1    Sutherland, D.J.2
  • 174
    • 0037080983 scopus 로고    scopus 로고
    • Different Smad2 partners bind a common hydrophobic pocket in Smad2 via a defined proline-rich motif
    • Randall, R.A., Germain, S., Inman, G.J., Bates, P.A., and Hill, C.S. 2002. Different Smad2 partners bind a common hydrophobic pocket in Smad2 via a defined proline-rich motif. EMBO J. 21: 145-156.
    • (2002) EMBO J. , vol.21 , pp. 145-156
    • Randall, R.A.1    Germain, S.2    Inman, G.J.3    Bates, P.A.4    Hill, C.S.5
  • 175
    • 0034695924 scopus 로고    scopus 로고
    • The yeast nuclear pore complex: Composition, architecture, and transport mechanism
    • Rout, M.P., Aitchison, J.D., Suprapto, A., Hjertaas, K., Zhao, Y., and Chait, B.T. 2000. The yeast nuclear pore complex: Composition, architecture, and transport mechanism. J. Cell Biol. 148: 635-651.
    • (2000) J. Cell Biol. , vol.148 , pp. 635-651
    • Rout, M.P.1    Aitchison, J.D.2    Suprapto, A.3    Hjertaas, K.4    Zhao, Y.5    Chait, B.T.6
  • 176
    • 0035252544 scopus 로고    scopus 로고
    • Transcriptional regulation of the Drosophila gene zen by competing Smad and Brinker inputs
    • Rushlow, C., Colosimo, P.F., Lin, M.C., Xu, M., and Kirov, N. 2001. Transcriptional regulation of the Drosophila gene zen by competing Smad and Brinker inputs. Genes & Dev. 15: 340-351.
    • (2001) Genes & Dev. , vol.15 , pp. 340-351
    • Rushlow, C.1    Colosimo, P.F.2    Lin, M.C.3    Xu, M.4    Kirov, N.5
  • 177
    • 0345255908 scopus 로고    scopus 로고
    • Nodal signaling in vertebrate development
    • Schier, A.F. 2003. Nodal signaling in vertebrate development. Annu. Rev. Cell Dev. Biol. 19: 589-621.
    • (2003) Annu. Rev. Cell Dev. Biol. , vol.19 , pp. 589-621
    • Schier, A.F.1
  • 178
    • 0346100493 scopus 로고    scopus 로고
    • PIAS/SUMO: New partners in transcriptional regulation
    • Schmidt, D. and Muller, S. 2003. PIAS/SUMO: New partners in transcriptional regulation. Cell. Mol. Life Sci. 60: 2561-2574.
    • (2003) Cell. Mol. Life Sci. , vol.60 , pp. 2561-2574
    • Schmidt, D.1    Muller, S.2
  • 179
    • 6344260070 scopus 로고    scopus 로고
    • The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation
    • Seo, S.R., Lallemand, F., Ferrand, N., Pessah, M., L'Hoste, S., Camonis, J., and Atfi, A. 2004. The novel E3 ubiquitin ligase Tiul1 associates with TGIF to target Smad2 for degradation. EMBO J. 23: 3780-3792.
    • (2004) EMBO J. , vol.23 , pp. 3780-3792
    • Seo, S.R.1    Lallemand, F.2    Ferrand, N.3    Pessah, M.4    L'Hoste, S.5    Camonis, J.6    Atfi, A.7
  • 181
    • 0037126303 scopus 로고    scopus 로고
    • Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage
    • Seoane, J., Le, H.V., and Massagué, J. 2002. Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage. Nature 419: 729-734.
    • (2002) Nature , vol.419 , pp. 729-734
    • Seoane, J.1    Le, H.V.2    Massagué, J.3
  • 182
    • 1642332084 scopus 로고    scopus 로고
    • Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation
    • Seoane, J., Le, H.V., Shen, L., Anderson, S.A., and Massagué, J. 2004. Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation. Cell 117: 211-223.
    • (2004) Cell , vol.117 , pp. 211-223
    • Seoane, J.1    Le, H.V.2    Shen, L.3    Anderson, S.A.4    Massagué, J.5
  • 183
    • 0031773264 scopus 로고    scopus 로고
    • TGF-β-induced phosphorylation of Smad3 regulates its interaction with coactivator p300/CREB-binding protein
    • Shen, X., Hu, P.P., Liberati, N.T., Datto, M.B., Frederick, J.P., and Wang, X.F. 1998. TGF-β-induced phosphorylation of Smad3 regulates its interaction with coactivator p300/CREB-binding protein. Mol. Biol. Cell 9: 3309-3319.
    • (1998) Mol. Biol. Cell , vol.9 , pp. 3309-3319
    • Shen, X.1    Hu, P.P.2    Liberati, N.T.3    Datto, M.B.4    Frederick, J.P.5    Wang, X.F.6
  • 184
    • 0038682002 scopus 로고    scopus 로고
    • Mechanisms of TGF-β signaling from cell membrane to the nucleus
    • Shi, Y. and Massagué, J. 2003. Mechanisms of TGF-β signaling from cell membrane to the nucleus. Cell 113: 685-700.
    • (2003) Cell , vol.113 , pp. 685-700
    • Shi, Y.1    Massagué, J.2
  • 185
    • 0030837455 scopus 로고    scopus 로고
    • A structural basis for mutational inactivation of the tumour suppressor Smad4
    • Shi, Y., Hata, A., Lo, R.S., Massagué, J., and Pavletich, N.P. 1997. A structural basis for mutational inactivation of the tumour suppressor Smad4. Nature 388: 87-93.
    • (1997) Nature , vol.388 , pp. 87-93
    • Shi, Y.1    Hata, A.2    Lo, R.S.3    Massagué, J.4    Pavletich, N.P.5
  • 186
    • 0032483544 scopus 로고    scopus 로고
    • Crystal structure of a Smad MH1 domain bound to DNA: Insights on DNA binding in TGF-β signaling
    • Shi, Y., Wang, Y.F., Jayaraman, L., Yang, H., Massagué, J., and Pavletich, N.P. 1998. Crystal structure of a Smad MH1 domain bound to DNA: Insights on DNA binding in TGF-β signaling. Cell 94: 585-594.
    • (1998) Cell , vol.94 , pp. 585-594
    • Shi, Y.1    Wang, Y.F.2    Jayaraman, L.3    Yang, H.4    Massagué, J.5    Pavletich, N.P.6
  • 187
    • 0037100660 scopus 로고    scopus 로고
    • Bone morphogenetic protein-4-induced activation of Xretpos is mediated by Smads and Olf-1/EBF associated zinc finger (OAZ)
    • Shim, S., Bae, N., and Han, J.K. 2002. Bone morphogenetic protein-4-induced activation of Xretpos is mediated by Smads and Olf-1/EBF associated zinc finger (OAZ). Nucleic Acids Res. 30: 3107-3117.
    • (2002) Nucleic Acids Res. , vol.30 , pp. 3107-3117
    • Shim, S.1    Bae, N.2    Han, J.K.3
  • 188
    • 0035024425 scopus 로고    scopus 로고
    • Swift is a novel BRCT domain coactivator of Smad2 in transforming growth factor β signaling
    • Shimizu, K., Bourillot, P.Y., Nielsen, S.J., Zorn, A.M., and Gurdon, J.B. 2001. Swift is a novel BRCT domain coactivator of Smad2 in transforming growth factor β signaling. Mol. Cell. Biol. 21: 3901-3912.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 3901-3912
    • Shimizu, K.1    Bourillot, P.Y.2    Nielsen, S.J.3    Zorn, A.M.4    Gurdon, J.B.5
  • 190
    • 0242499448 scopus 로고    scopus 로고
    • Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer
    • Siegel, P.M. and Massagué, J. 2003. Cytostatic and apoptotic actions of TGF-β in homeostasis and cancer. Nat. Rev. Cancer 3: 807-821.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 807-821
    • Siegel, P.M.1    Massagué, J.2
  • 191
    • 0042316912 scopus 로고    scopus 로고
    • Mad upregulation and Id2 repression accompany transforming growth factor (TGF)-β-mediated epithelial cell growth suppression
    • Siegel, P.M., Shu, W., and Massagué, J. 2003. Mad upregulation and Id2 repression accompany transforming growth factor (TGF)-β-mediated epithelial cell growth suppression. J. Biol. Chem. 278: 35444-35450.
    • (2003) J. Biol. Chem. , vol.278 , pp. 35444-35450
    • Siegel, P.M.1    Shu, W.2    Massagué, J.3
  • 193
    • 5144219680 scopus 로고    scopus 로고
    • Identification of a SUMO-binding motif that recognizes SUMO-modified proteins
    • Song, J., Durrin, L.K., Wilkinson, T.A., Krontiris, T.G., and Chen, Y. 2004. Identification of a SUMO-binding motif that recognizes SUMO-modified proteins. Proc. Natl. Acad. Sci. 101: 14373-14378.
    • (2004) Proc. Natl. Acad. Sci. , vol.101 , pp. 14373-14378
    • Song, J.1    Durrin, L.K.2    Wilkinson, T.A.3    Krontiris, T.G.4    Chen, Y.5
  • 194
    • 0032566611 scopus 로고    scopus 로고
    • Physical and functional interaction of murine and Xenopus Smad7 with bone morphogenetic protein receptors and transforming growth factor-β receptors
    • Souchelnytskyi, S., Nakayama, T., Nakao, A., Moren, A., Heldin, C.H., Christian, J.L., and ten Dijke, P. 1998. Physical and functional interaction of murine and Xenopus Smad7 with bone morphogenetic protein receptors and transforming growth factor-β receptors. J. Biol. Chem. 273: 25364-25370.
    • (1998) J. Biol. Chem. , vol.273 , pp. 25364-25370
    • Souchelnytskyi, S.1    Nakayama, T.2    Nakao, A.3    Moren, A.4    Heldin, C.H.5    Christian, J.L.6    Ten Dijke, P.7
  • 196
    • 0022628093 scopus 로고
    • Transforming Sloan-Kettering viruses generated from the cloned v-ski oncogene by in vitro and in vivo recombinations
    • Stavnezer, E., Barkas, A.E., Brennan, L.A., Brodeur, D., and Li, Y. 1986. Transforming Sloan-Kettering viruses generated from the cloned v-ski oncogene by in vitro and in vivo recombinations. J. Virol. 57: 1073-1083.
    • (1986) J. Virol. , vol.57 , pp. 1073-1083
    • Stavnezer, E.1    Barkas, A.E.2    Brennan, L.A.3    Brodeur, D.4    Li, Y.5
  • 197
    • 0034703087 scopus 로고    scopus 로고
    • Participation of Smad2, Smad3, and Smad4 in transforming growth factor (TGF-β)-induced activation of Smad7. THE TGF-β response element of the promoter requires functional Smad binding element and E-box sequences for transcriptional regulation
    • Stopa, M., Anhuf, D., Terstegen, L., Gatsios, P., Gressner, A.M., and Dooley, S. 2000. Participation of Smad2, Smad3, and Smad4 in transforming growth factor (TGF-β)-induced activation of Smad7. THE TGF-β response element of the promoter requires functional Smad binding element and E-box sequences for transcriptional regulation. J. Biol. Chem. 275: 29308-29317.
    • (2000) J. Biol. Chem. , vol.275 , pp. 29308-29317
    • Stopa, M.1    Anhuf, D.2    Terstegen, L.3    Gatsios, P.4    Gressner, A.M.5    Dooley, S.6
  • 198
    • 0033595704 scopus 로고    scopus 로고
    • Negative feedback regulation of TGF-β signaling by the SnoN oncoprotein
    • Stroschein, S.L., Wang, W., Zhou, S., Zhou, Q., and Luo, K. 1999. Negative feedback regulation of TGF-β signaling by the SnoN oncoprotein. Science 286: 771-774.
    • (1999) Science , vol.286 , pp. 771-774
    • Stroschein, S.L.1    Wang, W.2    Zhou, S.3    Zhou, Q.4    Luo, K.5
  • 199
    • 0035498980 scopus 로고    scopus 로고
    • Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN
    • Stroschein, S.L., Bonni, S., Wrana, J.L., and Luo, K. 2001. Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN. Genes & Dev. 15: 2822-2836.
    • (2001) Genes & Dev. , vol.15 , pp. 2822-2836
    • Stroschein, S.L.1    Bonni, S.2    Wrana, J.L.3    Luo, K.4
  • 200
    • 3442894138 scopus 로고    scopus 로고
    • Targeting endogenous transforming growth factor β receptor signaling in SMAD4-deficient human pancreatic carcinoma cells inhibits their invasive phenotype1
    • Subramanian, G., Schwarz, R.E., Higgins, L., McEnroe, G., Chakravarty, S., Dugar, S., and Reiss, M. 2004. Targeting endogenous transforming growth factor β receptor signaling in SMAD4-deficient human pancreatic carcinoma cells inhibits their invasive phenotype1. Cancer Res. 64: 5200-5211.
    • (2004) Cancer Res. , vol.64 , pp. 5200-5211
    • Subramanian, G.1    Schwarz, R.E.2    Higgins, L.3    McEnroe, G.4    Chakravarty, S.5    Dugar, S.6    Reiss, M.7
  • 201
    • 0033213606 scopus 로고    scopus 로고
    • Interaction of the Ski oncoprotein with Smad3 regulates TGF-β signaling
    • Sun, Y., Liu, X., Eaton, E.N., Lane, W.S., Lodish, H.F., and Weinberg, R.A. 1999a. Interaction of the Ski oncoprotein with Smad3 regulates TGF-β signaling. Mol. Cell 4: 499-509.
    • (1999) Mol. Cell , vol.4 , pp. 499-509
    • Sun, Y.1    Liu, X.2    Eaton, E.N.3    Lane, W.S.4    Lodish, H.F.5    Weinberg, R.A.6
  • 202
    • 0033607240 scopus 로고    scopus 로고
    • SnoN and ski protooncoproteins are rapidly degraded in response to transforming growth factor β signaling
    • Sun, Y., Liu, X., Ng-Eaton, E., Lodish, H.F., and Weinberg, R.A. 1999b. SnoN and ski protooncoproteins are rapidly degraded in response to transforming growth factor β signaling. Proc. Natl. Acad. Sci. 96: 12442-12447.
    • (1999) Proc. Natl. Acad. Sci. , vol.96 , pp. 12442-12447
    • Sun, Y.1    Liu, X.2    Ng-Eaton, E.3    Lodish, H.F.4    Weinberg, R.A.5
  • 203
    • 0035830503 scopus 로고    scopus 로고
    • Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms
    • Sun, Y., Nadal-Vicens, M., Misono, S., Lin, M.Z., Zubiaga, A., Hua, X., Fan, G., and Greenberg, M.E. 2001. Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms. Cell 104: 365-376.
    • (2001) Cell , vol.104 , pp. 365-376
    • Sun, Y.1    Nadal-Vicens, M.2    Misono, S.3    Lin, M.Z.4    Zubiaga, A.5    Hua, X.6    Fan, G.7    Greenberg, M.E.8
  • 205
    • 0038363366 scopus 로고    scopus 로고
    • Chromosomal region maintenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-β signaling by Smad7
    • Tajima, Y., Goto, K., Yoshida, M., Shinomiya, K., Sekimoto, T., Yoneda, Y., Miyazono, K., and Imamura, T. 2003. Chromosomal region maintenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-β signaling by Smad7. J. Biol. Chem. 278: 10716-10721.
    • (2003) J. Biol. Chem. , vol.278 , pp. 10716-10721
    • Tajima, Y.1    Goto, K.2    Yoshida, M.3    Shinomiya, K.4    Sekimoto, T.5    Yoneda, Y.6    Miyazono, K.7    Imamura, T.8
  • 207
    • 0031778749 scopus 로고    scopus 로고
    • The Tlx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development
    • Tang, S.J., Hoodless, P.A., Lu, Z., Breitman, M.L., McInnes, R.R., Wrana, J.L., and Buchwald, M. 1998. The Tlx-2 homeobox gene is a downstream target of BMP signalling and is required for mouse mesoderm development. Development 125: 1877-1887.
    • (1998) Development , vol.125 , pp. 1877-1887
    • Tang, S.J.1    Hoodless, P.A.2    Lu, Z.3    Breitman, M.L.4    McInnes, R.R.5    Wrana, J.L.6    Buchwald, M.7
  • 208
    • 0037462502 scopus 로고    scopus 로고
    • Disruption of transforming growth factor-β signaling in ELF β-spectrin-deficient mice
    • Tang, Y., Katuri, V., Dillner, A., Mishra, B., Deng, C.X., and Mishra, L. 2003. Disruption of transforming growth factor-β signaling in ELF β-spectrin-deficient mice. Science 299: 574-577.
    • (2003) Science , vol.299 , pp. 574-577
    • Tang, Y.1    Katuri, V.2    Dillner, A.3    Mishra, B.4    Deng, C.X.5    Mishra, L.6
  • 209
    • 0036333793 scopus 로고    scopus 로고
    • Wnt and Bmp signalling cooperatively regulate graded Emx2 expression in the dorsal telencephalon
    • Theil, T., Aydin, S., Koch, S., Grotewold, L., and Ruther, U. 2002. Wnt and Bmp signalling cooperatively regulate graded Emx2 expression in the dorsal telencephalon. Development 129: 3045-3054.
    • (2002) Development , vol.129 , pp. 3045-3054
    • Theil, T.1    Aydin, S.2    Koch, S.3    Grotewold, L.4    Ruther, U.5
  • 210
    • 0032482946 scopus 로고    scopus 로고
    • CREB binding protein is a required coactivator for Smad-dependent, transforming growth factor β transcriptional responses in endothelial cells
    • Topper, J.N., DiChiara, M.R., Brown, J.D., Williams, A.J., Falb, D., Collins, T., and Gimbrone Jr., M.A. 1998. CREB binding protein is a required coactivator for Smad-dependent, transforming growth factor β transcriptional responses in endothelial cells. Proc. Natl. Acad. Sci. 95: 9506-9511.
    • (1998) Proc. Natl. Acad. Sci. , vol.95 , pp. 9506-9511
    • Topper, J.N.1    DiChiara, M.R.2    Brown, J.D.3    Williams, A.J.4    Falb, D.5    Collins, T.6    Gimbrone Jr., M.A.7
  • 211
    • 0036170142 scopus 로고    scopus 로고
    • Identification of Sef, a novel modulator of FGF signalling
    • Tsang, M., Friesel, R., Kudoh, T., and Dawid, I.B. 2002. Identification of Sef, a novel modulator of FGF signalling. Nat. Cell Biol. 4: 165-169.
    • (2002) Nat. Cell Biol. , vol.4 , pp. 165-169
    • Tsang, M.1    Friesel, R.2    Kudoh, T.3    Dawid, I.B.4
  • 212
    • 0032428684 scopus 로고    scopus 로고
    • SARA, a FYVE domain protein that recruits Smad2 to the TGFβ receptor
    • Tsukazaki, T., Chiang, T.A., Davison, A.F., Attisano, L., and Wrana, J.L. 1998. SARA, a FYVE domain protein that recruits Smad2 to the TGFβ receptor. Cell 95: 779-791.
    • (1998) Cell , vol.95 , pp. 779-791
    • Tsukazaki, T.1    Chiang, T.A.2    Davison, A.F.3    Attisano, L.4    Wrana, J.L.5
  • 213
    • 0030863365 scopus 로고    scopus 로고
    • Daughters against dpp modulates dpp organizing activity in Drosophila wing development
    • Tsuneizumi, K., Nakayama, T., Kamoshida, Y., Kornberg, T.B., Christian, J.L., and Tabata, T. 1997. Daughters against dpp modulates dpp organizing activity in Drosophila wing development. Nature 389: 627-631.
    • (1997) Nature , vol.389 , pp. 627-631
    • Tsuneizumi, K.1    Nakayama, T.2    Kamoshida, Y.3    Kornberg, T.B.4    Christian, J.L.5    Tabata, T.6
  • 214
    • 0033602101 scopus 로고    scopus 로고
    • Inhibition of transforming growth factor-β/SMAD signalling by the interferon-γ/STAT pathway
    • Ulloa, L., Doody, J., and Massagué, J. 1999. Inhibition of transforming growth factor-β/SMAD signalling by the interferon-γ/STAT pathway. Nature 397: 710-713.
    • (1999) Nature , vol.397 , pp. 710-713
    • Ulloa, L.1    Doody, J.2    Massagué, J.3
  • 216
    • 0034646674 scopus 로고    scopus 로고
    • Smad3 and Smad4 mediate transcriptional activation of the human Smad7 promoter by transforming growth factor β
    • von Gersdorff, G., Susztak, K., Rezvani, F., Bitzer, M., Liang, D., and Bottinger, E.P. 2000. Smad3 and Smad4 mediate transcriptional activation of the human Smad7 promoter by transforming growth factor β. J. Biol. Chem. 275: 11320-11326.
    • (2000) J. Biol. Chem. , vol.275 , pp. 11320-11326
    • Von Gersdorff, G.1    Susztak, K.2    Rezvani, F.3    Bitzer, M.4    Liang, D.5    Bottinger, E.P.6
  • 217
    • 0032549806 scopus 로고    scopus 로고
    • Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo
    • Waldrip, W.R., Bikoff, E.K., Hoodless, P.A., Wrana, J.L., and Robertson, E.J. 1998. Smad2 signaling in extraembryonic tissues determines anterior-posterior polarity of the early mouse embryo. Cell 92: 797-808.
    • (1998) Cell , vol.92 , pp. 797-808
    • Waldrip, W.R.1    Bikoff, E.K.2    Hoodless, P.A.3    Wrana, J.L.4    Robertson, E.J.5
  • 220
    • 0034687731 scopus 로고    scopus 로고
    • Ski represses bone morphogenic protein signaling in Xenopus and mammalian cells
    • Wang, W., Mariani, F.V., Harland, R.M., and Luo, K. 2000. Ski represses bone morphogenic protein signaling in Xenopus and mammalian cells. Proc. Natl. Acad. Sci. 97: 14394-14399.
    • (2000) Proc. Natl. Acad. Sci. , vol.97 , pp. 14394-14399
    • Wang, W.1    Mariani, F.V.2    Harland, R.M.3    Luo, K.4
  • 221
    • 0034252221 scopus 로고    scopus 로고
    • Regulation of intracellular dynamics of Smad4 by its leucine-rich nuclear export signal
    • Watanabe, M., Masuyama, N., Fukuda, M., and Nishida, E. 2000. Regulation of intracellular dynamics of Smad4 by its leucine-rich nuclear export signal. EMBO Rep. 1: 176-182.
    • (2000) EMBO Rep. , vol.1 , pp. 176-182
    • Watanabe, M.1    Masuyama, N.2    Fukuda, M.3    Nishida, E.4
  • 223
    • 0032529159 scopus 로고    scopus 로고
    • Smads and early developmental signaling by the TGFβ superfamily
    • Whitman, M. 1998. Smads and early developmental signaling by the TGFβ superfamily. Genes & Dev. 12: 2445-2462.
    • (1998) Genes & Dev. , vol.12 , pp. 2445-2462
    • Whitman, M.1
  • 224
    • 0033780420 scopus 로고    scopus 로고
    • Inactivation of smad-transforming growth factor β signaling by Ca(2+)-calmodulin-dependent protein kinase II
    • Wicks, S.J., Lui, S., Abdel-Wahab, N., Mason, R.M., and Chantry, A. 2000. Inactivation of smad-transforming growth factor β signaling by Ca(2+)-calmodulin-dependent protein kinase II. Mol. Cell. Biol. 20: 8103-8111.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 8103-8111
    • Wicks, S.J.1    Lui, S.2    Abdel-Wahab, N.3    Mason, R.M.4    Chantry, A.5
  • 225
    • 0030886059 scopus 로고    scopus 로고
    • Concentration-dependent patterning of the Xenopus ectoderm by BMP4 and its signal transducer Smad1
    • Wilson, P.A., Lagna, G., Suzuki, A., and Hemmati-Brivanlou, A. 1997. Concentration-dependent patterning of the Xenopus ectoderm by BMP4 and its signal transducer Smad1. Development 124: 3177-3184.
    • (1997) Development , vol.124 , pp. 3177-3184
    • Wilson, P.A.1    Lagna, G.2    Suzuki, A.3    Hemmati-Brivanlou, A.4
  • 227
    • 0032979988 scopus 로고    scopus 로고
    • Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor β
    • Wong, C., Rougier-Chapman, E.M., Frederick, J.P., Datto, M.B., Liberati, N.T., Li, J.M., and Wang, X.F. 1999. Smad3-Smad4 and AP-1 complexes synergize in transcriptional activation of the c-Jun promoter by transforming growth factor β. Mol. Cell. Biol. 19: 1821-1830.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 1821-1830
    • Wong, C.1    Rougier-Chapman, E.M.2    Frederick, J.P.3    Datto, M.B.4    Liberati, N.T.5    Li, J.M.6    Wang, X.F.7
  • 228
    • 0033515620 scopus 로고    scopus 로고
    • A Smad transcriptional corepressor
    • Wotton, D., Lo, R.S., Lee, S., and Massagué, J. 1999a. A Smad transcriptional corepressor. Cell 97: 29-39.
    • (1999) Cell , vol.97 , pp. 29-39
    • Wotton, D.1    Lo, R.S.2    Lee, S.3    Massagué, J.4
  • 229
    • 0033601272 scopus 로고    scopus 로고
    • Multiple modes of repression by the Smad transcriptional corepressor TGIF
    • Wotton, D., Lo, R.S., Swaby, L.A., and Massagué, J. 1999b. Multiple modes of repression by the Smad transcriptional corepressor TGIF. J. Biol. Chem. 274: 37105-37110.
    • (1999) J. Biol. Chem. , vol.274 , pp. 37105-37110
    • Wotton, D.1    Lo, R.S.2    Swaby, L.A.3    Massagué, J.4
  • 232
    • 0035827668 scopus 로고    scopus 로고
    • Formation of a stable heterodimer between Smad2 and Smad4
    • Wu, J.W., Fairman, R., Penry, J., and Shi, Y. 2001a. Formation of a stable heterodimer between Smad2 and Smad4. J. Biol. Chem. 276: 20688-20694.
    • (2001) J. Biol. Chem. , vol.276 , pp. 20688-20694
    • Wu, J.W.1    Fairman, R.2    Penry, J.3    Shi, Y.4
  • 233
    • 18244362844 scopus 로고    scopus 로고
    • Crystal structure of a phosphorylated Smad2. Recognition of phosphoserine by the MH2 domain and insights on Smad function in TGF-β signaling
    • Wu, J.W., Hu, M., Chai, J., Seoane, J., Huse, M., Li, C., Rigotti, D.J., Kyin, S., Muir, T.W., Fairman, R., et al. 2001b. Crystal structure of a phosphorylated Smad2. Recognition of phosphoserine by the MH2 domain and insights on Smad function in TGF-β signaling. Mol. Cell 8: 1277-1289.
    • (2001) Mol. Cell , vol.8 , pp. 1277-1289
    • Wu, J.W.1    Hu, M.2    Chai, J.3    Seoane, J.4    Huse, M.5    Li, C.6    Rigotti, D.J.7    Kyin, S.8    Muir, T.W.9    Fairman, R.10
  • 234
    • 0036848069 scopus 로고    scopus 로고
    • Structural mechanism of Smad4 recognition by the nuclear oncoprotein Ski: Insights on Ski-mediated repression of TGF-β signaling
    • Wu, J.W., Krawitz, A.R., Chai, J., Li, W., Zhang, F., Luo, K., and Shi, Y. 2002. Structural mechanism of Smad4 recognition by the nuclear oncoprotein Ski: Insights on Ski-mediated repression of TGF-β signaling. Cell 111: 357-367.
    • (2002) Cell , vol.111 , pp. 357-367
    • Wu, J.W.1    Krawitz, A.R.2    Chai, J.3    Li, W.4    Zhang, F.5    Luo, K.6    Shi, Y.7
  • 236
    • 0034604343 scopus 로고    scopus 로고
    • Importin β mediates nuclear translocation of Smad 3
    • Xiao, Z., Liu, X., and Lodish, H.F. 2000. Importin β mediates nuclear translocation of Smad 3. J. Biol. Chem. 275: 23425-23428.
    • (2000) J. Biol. Chem. , vol.275 , pp. 23425-23428
    • Xiao, Z.1    Liu, X.2    Lodish, H.F.3
  • 238
    • 1542284152 scopus 로고    scopus 로고
    • Nucleocytoplasmic shuttling of signal transducers
    • Xu, L. and Massagué, J. 2004. Nucleocytoplasmic shuttling of signal transducers. Nat. Rev. Mol. Cell Biol. 5: 209-219.
    • (2004) Nat. Rev. Mol. Cell Biol. , vol.5 , pp. 209-219
    • Xu, L.1    Massagué, J.2
  • 239
    • 0032145411 scopus 로고    scopus 로고
    • Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to the Drosophila mesoderm
    • Xu, X., Yin, Z., Hudson, J.B., Ferguson, E.L., and Frasch, M. 1998. Smad proteins act in combination with synergistic and antagonistic regulators to target Dpp responses to the Drosophila mesoderm. Genes & Dev. 12: 2354-2370.
    • (1998) Genes & Dev. , vol.12 , pp. 2354-2370
    • Xu, X.1    Yin, Z.2    Hudson, J.B.3    Ferguson, E.L.4    Frasch, M.5
  • 240
    • 0034253480 scopus 로고    scopus 로고
    • The nuclear import function of Smad2 is masked by SARA and unmasked by TGFβ-dependent phosphorylation
    • Xu, L., Chen, Y.G., and Massagué, J. 2000. The nuclear import function of Smad2 is masked by SARA and unmasked by TGFβ-dependent phosphorylation. Nat. Cell Biol. 2: 559-562.
    • (2000) Nat. Cell Biol. , vol.2 , pp. 559-562
    • Xu, L.1    Chen, Y.G.2    Massagué, J.3
  • 241
    • 0036670359 scopus 로고    scopus 로고
    • Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFβ signaling complexes in the cytoplasm and nucleus
    • Xu, L., Kang, Y., Col, S., and Massagué, J. 2002. Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFβ signaling complexes in the cytoplasm and nucleus. Mol. Cell 10: 271-282.
    • (2002) Mol. Cell , vol.10 , pp. 271-282
    • Xu, L.1    Kang, Y.2    Col, S.3    Massagué, J.4
  • 242
    • 0142211206 scopus 로고    scopus 로고
    • Distinct domain utilization by Smad3 and Smad4 for nucleoporin interaction and nuclear import
    • Xu, L., Alarcon, C., Col, S., and Massagué, J. 2003. Distinct domain utilization by Smad3 and Smad4 for nucleoporin interaction and nuclear import. J. Biol. Chem. 278: 42569-42577.
    • (2003) J. Biol. Chem. , vol.278 , pp. 42569-42577
    • Xu, L.1    Alarcon, C.2    Col, S.3    Massagué, J.4
  • 243
    • 0033534573 scopus 로고    scopus 로고
    • Alternatively spliced variant of Smad2 lacking exon 3. Comparison with wild-type Smad2 and Smad3
    • Yagi, K., Goto, D., Hamamoto, T., Takenoshita, S., Kato, M., and Miyazono, K. 1999. Alternatively spliced variant of Smad2 lacking exon 3. Comparison with wild-type Smad2 and Smad3. J. Biol. Chem. 274: 703-709.
    • (1999) J. Biol. Chem. , vol.274 , pp. 703-709
    • Yagi, K.1    Goto, D.2    Hamamoto, T.3    Takenoshita, S.4    Kato, M.5    Miyazono, K.6
  • 244
    • 0034708737 scopus 로고    scopus 로고
    • The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors
    • Yahata, T., de Caestecker, M.P., Lechleider, R.J., Andriole, S., Roberts, A.B., Isselbacher, K.J., and Shioda, T. 2000. The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors. J. Biol. Chem. 275: 8825-8834.
    • (2000) J. Biol. Chem. , vol.275 , pp. 8825-8834
    • Yahata, T.1    De Caestecker, M.P.2    Lechleider, R.J.3    Andriole, S.4    Roberts, A.B.5    Isselbacher, K.J.6    Shioda, T.7
  • 245
    • 0037007204 scopus 로고    scopus 로고
    • The rasGAP-binding protein, Dok-1, mediates activin signaling via serine/threonine kinase receptors
    • Yamakawa, N., Tsuchida, K., and Sugino, H. 2002. The rasGAP-binding protein, Dok-1, mediates activin signaling via serine/threonine kinase receptors. EMBO J. 21: 1684-1694.
    • (2002) EMBO J. , vol.21 , pp. 1684-1694
    • Yamakawa, N.1    Tsuchida, K.2    Sugino, H.3
  • 246
    • 1542285164 scopus 로고    scopus 로고
    • SUMO promotes HDAC-mediated transcriptional repression
    • Yang, S.H. and Sharrocks, A.D. 2004. SUMO promotes HDAC-mediated transcriptional repression. Mol. Cell 13: 611-617.
    • (2004) Mol. Cell , vol.13 , pp. 611-617
    • Yang, S.H.1    Sharrocks, A.D.2
  • 247
    • 0032910953 scopus 로고    scopus 로고
    • β-Catenin can be transported into the nucleus in a Ran-unassisted manner
    • Yokoya, F., Imamoto, N., Tachibana, T., and Yoneda, Y. 1999. β-Catenin can be transported into the nucleus in a Ran-unassisted manner. Mol. Biol. Cell 10: 1119-1131.
    • (1999) Mol. Biol. Cell , vol.10 , pp. 1119-1131
    • Yokoya, F.1    Imamoto, N.2    Tachibana, T.3    Yoneda, Y.4
  • 252
    • 0034595970 scopus 로고    scopus 로고
    • Transcriptional regulation of the transforming growth factor-β-inducible mouse germ line Ig α constant region gene by functional cooperation of Smad, CREB, and AML family members
    • Zhang, Y. and Derynck, R. 2000. Transcriptional regulation of the transforming growth factor-β-inducible mouse germ line Ig α constant region gene by functional cooperation of Smad, CREB, and AML family members. J. Biol. Chem. 275: 16979-16985.
    • (2000) J. Biol. Chem. , vol.275 , pp. 16979-16985
    • Zhang, Y.1    Derynck, R.2
  • 253
    • 0029786212 scopus 로고    scopus 로고
    • Receptor-associated Mad homologues synergize as effectors of the TGF-β response
    • Zhang, Y., Feng, X., We, R., and Derynck, R. 1996. Receptor-associated Mad homologues synergize as effectors of the TGF-β response. Nature 383: 168-172.
    • (1996) Nature , vol.383 , pp. 168-172
    • Zhang, Y.1    Feng, X.2    We, R.3    Derynck, R.4
  • 254
    • 0032572723 scopus 로고    scopus 로고
    • Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription
    • Zhang, Y., Feng, X.H., and Derynck, R. 1998. Smad3 and Smad4 cooperate with c-Jun/c-Fos to mediate TGF-β-induced transcription. Nature 394: 909-913.
    • (1998) Nature , vol.394 , pp. 909-913
    • Zhang, Y.1    Feng, X.H.2    Derynck, R.3
  • 255
    • 0033549789 scopus 로고    scopus 로고
    • A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation
    • Zhu, H., Kavsak, P., Abdollah, S., Wrana, J.L., and Thomsen, G.H. 1999. A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. Nature 400: 687-693.
    • (1999) Nature , vol.400 , pp. 687-693
    • Zhu, H.1    Kavsak, P.2    Abdollah, S.3    Wrana, J.L.4    Thomsen, G.H.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.