A conserved docking motif in MAP kinases common to substrates, activators and regulators

Nature Cell Biology

Volumn 2, Issue 2, 2000, Pages 110-116

  Tanoue, Takuji ^a   Adachi, Makoto ^a   Moriguchi, Tetsuo ^a   Nishida, Eisuke ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC ACID; DOCKING PROTEIN; ENZYME ACTIVATOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE PHOSPHATASE; PHOSPHATASE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; ENZYME STRUCTURE; ENZYME SUBSTRATE; HUMAN; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; BINDING SITES; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CONSERVED SEQUENCE; MAP KINASE KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN BINDING; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE-PHOSPHATASE;

ANIMALIA;

EID: 0033788484     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/35000065     Document Type: Article

References (40)

1. The mitogen-activated protein kinase activator
2. The MAP kinase cascade is essential for diverse signal transduction pathways
3. How MAP kinases are regulated
4. Recent progress in characterization of protein kinase cascades for phosphorylation of ribosomal protein S6
5. MAPKs: New JNK expands the group
6. Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
7. Protein kinase cascades activated by stress and inflammation
8. Regulation of transcription by MAP kinase cascades
9. A conserved motif at the amino termini of MEKs might mediate high-affinity interaction with the cognate MAPKs
10. c-Jun recruits JNK to phosphorylate dimerization partners via specific docking interactions
11. Interaction of MAP kinase with MAP kinase kinase: Its possible role in the control of nucleocytoplasmic transport of MAP kinase
12. PTP-SL and STEP protein tyrosine phosphatases regulate the activation of the extracellular signal-regulated kinases ERK1 and ERK2 by association through a kinase interaction motif
13. JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension
14. Differential targeting of MAP kinases to the ETS-domain transcription factor Elk-1
15. A MAP kinase docking site is required for phosphorylation and activation of p90RSK/MAPKAPK-1
16. Protein modification: Docking sites for kinases
17. Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase
18. Identification of an extracellular signal-regulated kinase (ERK) docking site in ribosomal S6 kinase, a sequence critical for activation by ERK in vivo
19. Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors
20. Interaction of mitogen-activated protein kinases with the kinase interaction motif of the tyrosine phosphatase PTP-SL provides substrate specificity and retains ERK2 in the cytoplasm
21. A gain-of-function mutation in Drosophila MAP kinase activates multiple receptor tyrosine kinase signaling pathways
22. Catalytic activation of the phosphatase MKP3 by ERK2 mitogen-activated protein kinase
23. Atomic structure of the MAP kinase ERK2 at 2.3 resolution
24. MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates
25. Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2
26. Proteolytic inactivation of MAP-kinase kinase by Anthrax Lethal Factor
27. The sevenmaker gain-of-function mutation in p42 MAP kinase leads to enhanced signalling and reduced sensitivity to dual specificity phosphatase action
28. The mitogen-activated protein kinase phosphatases PAC1, MKP-1, and MKP-2 have unique substrate specificities and reduced activity in vivo toward the ERK2 sevenmaker mutation
29. PTP-ER, a novel tyrosine phosphatase, functions downstream of Ras1 to downregulate MAP kinase during Drosophila eye development
30. Crystal structure of p38 mitogen-activated protein kinase
31. The structure of mitogen-activated protein kinase p38 at 2.1- A resolution
32. Crystal structure of JNK3: A kinase implicated in neuronal apoptosis
33. 2
34. Molecular cloning and characterization of a novel dual specificity phosphatase, MKP-5
35. Phosphorylation of the MAP kinase ERK2 promotes its homodimerization and nuclear translocation
36. Identification of MAP kinase domains by redirecting stress signals into growth factor responses
37. Phosphorylation of MAP kinases by MAPK/ERK kinases involves multiple regions of MAP kinases
38. Characterization of the structure and function of a novel MAP kinase kinase (MKK6)
39. 2-terminal kinase kinases
40. Conditionally oncogenic forms of the A-Raf and B-Raf protein kinases display different biological and biochemical properties in NIH 3T3 cells