HPK1, a hematopoietic protein kinase activating the SAPK/JNK pathway

EMBO Journal

Volumn 15, Issue 24, 1996, Pages 7013-7025

  Kiefer, Friedemann ^a,b   Tibbles, Lee Anne ^a   Anafi, Mordechai ^b   Janssen, Ann ^c   Zanke, Brent W ^a   Lassam, Norman ^a   Pawson, Tony ^b   Woodgett, James R ^a   Iscove, Norman N ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b MOUNT SINAI HOSPITAL   (Canada)

^c AMGEN INC   (United States)

Author keywords

Hemopoiesis; HPK1; MLK 3; SAPK

Indexed keywords

ANTIINFECTIVE AGENT; CYTOKINE; PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA TRANSFECTION; ENZYME ACTIVATION; GENE EXPRESSION; GROWTH REGULATION; HEAT INJURY; HEMATOPOIESIS; INJURY; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN DOMAIN; RADIATION INJURY;

EID: 0030481580     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1460-2075.1996.tb01093.x     Document Type: Article

References (60)

1. Altschul,S.F., Gish,W., Miller,W., Myers,E.W. and Lipman,D.J. (1990) Basic local alignment search tool. J. Mol. Biol., 215, 403-410.
2. Ausubel,F., Brent,M.R., Kingston,R.E., Moore,D.D., Seidman,J.G., Smith,J.A. and Struhl,K. (1990) Current Protocols in Molecular Biology. John Wiley and Sons, New York.
3. Bagrodia,S., Taylor,S.J., Creas,C.L., Chernoff,J. and Cerione,R.A. (1995) Identification of a mouse p21Cdc42/Rac activated kinase. J. Biol. Chem., 270, 22731-22737.
4. ras, Raf-1, and MAP kinase kinase. J. Biol. Chem., 269, 31839-31844.
5. Brady,G. and Iscove,N.N. (1993) Construction of cDNA libraries from single cells. Methods Enzymol., 225, 611-623.
6. Brady,G., Barbara,M. and Iscove,N.N. (1990) Representative in vitro cDNA amplification from individual hemopoietic cells and colonies. Methods Mol. Cell. Biol., 2, 17-25.
7. Brady,G. et al. (1995) Analysis of gene expression in a complex differentiation hierarchy by global amplification of cDNA from single cells. Curr. Biol., 5, 909-922.
8. Brown,J.L., Stowers,L., Baer,M., Trejo,J.A., Coughlin,S. and Chant,J. (1996) Human Ste 20 homologue hPAK1 links GTPases to the JNK MAP kinase pathway. Curr. Biol., 6, 598-605.
9. Burbelo,P.D., Drechsel,D. and Hall,A. (1995) A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases. J. Biol. Chem., 270, 29071-29074.
10. Cano,E. and Mahadevan,L.C. (1995) Parallel signal processing among mammalian MAPKs. Trends Biochem. Sci., 20, 117-122.
11. Chernoff,J. Direct submission, GenBank accession No. U24153.
12. Cosman,D. (1993) The hematopoietin receptor superfamily. Cytokine, 5, 95-106.
13. Coso,O.A., Chiariello,M., Yu,J.C., Teramoto,H., Crespo,P. Xu,N., Miki,T. and Gutkind,J.S. (1995) The small GTP-binding proteins Rac1 and CDC42 regulate the activity of the JNK/SAPK signaling pathway. Cell, 81, 1137-1146.
14. Cumano,A., Paige,C.J., Iscove,N.N. and Brady,G. (1992) Bipotential precursors of B cells and macrophages in murine fetal liver. Nature, 356, 612-615.
15. Dérijard,B., Raingeaud,J., Barrett,T., Wu,I.H., Han,J., Ulevitch,R.J. and Davis,R. (1995) Independent human MAP kinase signal transduction pathways defined by MEK and MKK isoforms. Science, 267, 682-685.
16. Dexter,T.M., Garland,J., Scott,D., Scolnick,E. and Metcalf,D. (1980) Growth of factor-dependent hemopoietic precursor cell lines. J. Exp. Med., 152, 1036-1047.
17. Durfee,T., Becherer,K., Chen,P.-L., Yeh,S.-H., Yang,Y., Kilburn,A.E., Lee,W.-H. and Elledge,S.J. (1993) The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit. Genes Dev., 7, 555-569.
18. Ezoe,K., Lee,S.-T., Strunk,K.M. and Spritz,R.A. (1994) PTK1, a novel protein kinase required for proliferation of human melanocytes. Oncogene, 9, 935-948.
19. Field,J., Nikawa,J.-I., Broek,D., MacDonald,B., Godgers,L., Wilson,I.A., Lerner,R. and Wigler,M. (1988) Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method. Mol. Cell Biol. 8, 2159-2165.
20. Gallo,K.A., Mark,M.R., Scadden,D.T., Wang,Z., Gu,Q. and Godowski,P. (1994) Identification and characterization of SPRK, a novel srchomology 3 domain containing proline rich kinase with serine/threonine kinase activity. J. Biol. Chem., 21, 15092-15100.
21. Greenberger,J.S., Sakakeeny,M.A., Humphries,R.K., Eaves,C.J. and Eckner,R.J. (1983) Demonstration of permanent factor-dependent multipotential (erythroid/neutrophil/basophil) hematopoietic progenitor cell lines. Proc. Natl Acad. Sci. USA, 80, 2931-2935.
22. Gibbs,C.S., and Zoller,M.J. (1991) Rational scanning mutagenesis of a protein kinase identifies functional regions involved in catalysis and substrate interactions. J. Biol. Chem., 266, 8923-8931.
23. Han,J., Lee,J.-D., Bibbs,L. and Ulevitch,R.J. (1994) A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science, 265, 808-811.
24. Han,J., Lee,J.-D., Jiang,Y., Li,Z., Feng,L. and Ulevitch,R.J. (1996) Characterization of the structure and function of a novel MAP kinase kinase (MKK6). J. Biol. Chem., 271, 2886-2891.
25. Herskowitz,I. (1995) MAP kinase pathways in yeast: for mating and more. Cell, 80, 187-197.
26. Hirai,S., Izawa,M., Osada,S.-I., Spyrou,G. and Ohno,S. (1996) Activation of the JNK pathway by distantly related protein kinases, MEKK and MUK. Oncogene, 12, 641-650.
27. Ihle,J.N., Rein,A. and Mural,R. (1984) Immunologic and virologic mechanisms in retrovirus-induced murine leukemogenesis. Adv. Viral Oncol, 4, 95-137.
28. Ing,Y.L., Leung,I.W.L., Heng,H.H.Q., Tsui,L.C. and Lassam,N.J. (1994) MLK-3: identification of a widely-expressed protein kinase bearing an SH3 domain and a leucine zipper basic region domain. Oncogene, 9, 1745-1750.
29. Iscove,N.N., Fagg,B. and Keller,G. (1988) A soluble activity from adherent marrow cells cooperates with IL-3 in stimulating growth of pluripotential hematopoietic precursors. Blood, 71, 953-957.
30. Karasuyama,H. and Melchers,F. (1988) Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors. Eur. J. Immunol., 18, 97-104.
31. Katz,P., Whalen,G., and Kerl,J.H. (1994) Differential expression of a novel protein kinase in human B lymphocytes. J. Biol. Chem., 269, 16802-16809.
32. Kaufman,R.J., Davies,M.V., Pathak,V.K. and Hershey,J.W.B. (1989) The phosphorylation state of eucaryotic initiation factor 2 alters translational efficiency of specific mRNAs. Mol. Cell. Biol., 9, 946-958.
33. Kharbanda,S., Pandey,P., Ren,R., Mayer,B., Zon,L. and Kufe,D. (1995a) c-Abl activation regulates induction of the SEK1/stress-activated protein kinase pathway in the cellular response to 1-ß-D-arabinofuranosylcylosine. J. Biol. Chem., 270, 30278-30281.
34. Kharbanda,S., Ren,R., Pandey,P., Shafman,T.D., Feller,S.M., Weichselbaum,R.R. and Kufe,D. (1995b) Activation of the c-Abl tyrosine kinase in the stress response to DNA-damaging agents. Nature, 376, 785-788.
35. Knaus,U.G., Morris,S., Dong,H.-J., Chernoff,J. and Bokoch,G.M. (1995) Regulation of human leukocyte p21-activated kinases through G protein-coupled receptors. Science, 269, 221-223.
36. Kozak,M. (1986) Point mutations define a sequence flanking the AUG initiator codon that modulates translation by eukaryotic ribosomes. Cell, 44, 283-292.
37. Krieg,P.A. and Melton,D.A. (1984) Functional messenger RNAs are produced by SP6 in vitro transcription of cloned cDNAs. Nucleic Acids Res., 12, 7057-7070.
38. Kyriakis,J.M. Banerjee,P., Nikolakaki,E., Dai,T., Rubie,E.A., Ahmad,M.F., Avruch,J. and Woodgett,J.R. (1994) The stress-activated protein kinase subfamily of c-Jun kinases. Nature, 369, 156-160.
39. Ma,W., Hu,Z.-B. and Drexler,H.G. (1994) Sensitivity of different methods for the detection of myeloperoxidase in leukemia cells. Leukemia, 8, 336-342.
40. Maeda,T., Takekawa,M. and Saito,H. (1995) Activation of yeast PBS2 MAPKK by MAPKKKs or by binding of an SH3-containing osmosensor. Science, 269, 554-558.
41. PAK protein kinases, is a component of a Ras/Cdc42 signaling module in the fission yeast Schizosaccharomyces pombe. Proc. Natl Acad. Sci. USA, 92, 6180-6184.
42. Minden,A., Lin,A., McMahon,M., Lange-Carter,C., Dérijard,B., Davis,R., Johnson,G.L. and Karin,M. (1994) Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK. Science, 266, 1719-1723.
43. Minden,A., Lin,A., Claret,F.-X., Abo,A. and Karin,M. (1995) Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell, 81, 1147-1157.
44. Mueller,P.R., Coleman,T.R., Kumagai,A. and Dunphi,W.G. (1995) Myt1: a membrane-associated inhibitory kinase that phosphorylates Cdc2 on both threonine-14 and tyrosine-15. Science, 270, 86-90.
45. Paige,C.J., Kincade,P.W. and Ralph,P. (1978) Murine B cell leukemia line with inducible surface immunoglobulin expression. J. Immunol., 121, 641-647.
46. Patriotis,C., Makris,A., Bear,S. and Tsichlis,P.N. (1993) Tumor progression locus 2 (Tpl-2) encodes a protein kinase involved in the progression of rodent T-cell lymphomas and in T-cell activation. Proc. Natl Acad. Sci. USA, 90, 2251-2255.
47. Pawson,T. (1995) Protein modules and signalling networks. Nature, 373, 573-580.
48. Pombo,C.M., Kehrl,J.H., Sánchez,I., Katz,P., Avruch,J., Zon,L.I., Woodgett,J.R., Force,T. and Kyriakis,J.M. (1995) Activation of the SAP kinase pathway by germinal centre kinase, a human STE20 homolog. Nature, 377, 750-754.
49. Raingeaud,J., Witmarsh,A.J., Barrett,T., Dérijard,B. and Davies,R.J. (1996) MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway. Mol. Cell. Biol., 16, 1247-1255.
50. Ramer,S.W. and Davis,R.W. (1993) A dominant truncation allele identifies a gene, STE20, that encodes a putative protein kinase necessary for mating in Saccharomyces cerevisiae. Proc. Natl Acad. Sci. USA, 90, 452-456.
51. Salmerón,A., Ahmad,T.B., Carlile,G.W., Pappin,D., Narsimhan,R.P. and Ley,S.C. (1996) Activation of MEK-1 and SEK-1 by Tpl-2 protooncogene, a novel MAP kinase kinase kinase. EMBO J., 15, 817-826.
52. Sanchez,I., Hughes,R.T., Mayer,B.J., Yee,K., Woodgett,J.R., Avruch,J., Kyriakis,J.M. and Zon,L.I. (1994) SAP/ERK kinase-1 (SEKI) defines the SAPK pathway regulating c-Jun N-terminal phosphorylation. Nature, 372, 794-798.
53. Taniguchi,T. (1995) Cylokine signaling through nonreceptor protein tyrosine kinases. Science, 268, 251-255.
54. Tibbles,L.A., Ing,Y.L., Kiefer,F., Chan,J., Iscove,N., Woodgett,J.R. and Lassam,N. (1996) MIK-3 activates the SAPK/JNK and p38/RK pathways via SEK1 and MKK3/6. EMBO J., 15, 7026-7035.
55. Verheij,M. et al. (1996) Requirement for ceramide-initiated SAPK/JNK signalling in stress-induced apoptosis. Nature, 380, 75-79.
56. Wang,Z.-Q., Grigoriadis,A.E., Moehle-Steinlein,U. and Wagner,E.F. (1991) A novel target cell for c-fos-induced oncogenesis: development of chondrogenic tumors in embryonic stem cell chimeras. EMBO J., 10, 2437-2450.
57. Warner,N.L., Moore,M.A.S. and Metcalf,D. (1969) A transplantable myelomonocytic leukemia on BALB-c mice: cytology, karyotype, and muramidase content. J. Natl. Cancer Inst., 43, 963-982.
58. Woodgett,J.R., Kyriakis,J.M., Avruch,J., Zon,L.I., Zanke,B. and Templeton,D.J. (1996) Reconstitution of novel signalling cascades responding to cellular stresses. Philos. Trans. R. Soc. Lond., 351, 135-142.
59. Yan,M., Dai,T., Deak,J.C., Kyriakis,J.M., Zon,L.I., Woodgett,J.R. and Templeton,D.J. (1994) MEKK1 activates the stress activated protein kinase (SAPK) in vivo, not MAP kinase, via direct phosphorylation of the SAPK activator SEK1. Nature, 372, 798-800.
60. Zhang,S., Han,J., Sells,M.A., Chernoff,J., Knaus,U.G., Ulevitch,R.J. and Bokoch,G.M. (1995) Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1. J. Biol. Chem., 270, 23934-23936.