MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway

Molecular and Cellular Biology

Volumn 16, Issue 3, 1996, Pages 1247-1255

  Raingeaud, Joël ^a   Whitmarsh, Alan J ^a   Barrett, Tamera ^a   Dérijard, Benoit ^a   Davis, Roger J ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE;

ARTICLE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENE EXPRESSION; GENETIC REGULATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MOLECULAR CLONING; PRIORITY JOURNAL; PROTEIN DOMAIN; REPORTER GENE; SIGNAL TRANSDUCTION; STRESS;

AMINO ACID SEQUENCE; ANIMALS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL LINE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE TRANSFER TECHNIQUES; HUMANS; MAP KINASE KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; MOLECULAR SEQUENCE DATA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION;

CERVUS ELAPHUS;

EID: 0030051528     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.16.3.1247     Document Type: Article

References (65)

1. Adler, V., T. Unlap, and A. S. Kraft. 1994. A peptide encoding the c-Jun δ domain inhibas the activity of a c-Jun amino-terminal protein kinase J Biol. Chem. 269:11186-11191.
2. Ann, N. G., R. Seger, and E. G. Krebs. 1992. The mitogen-activated protein kinase activator. Curr. Opin. Cell Biol. 4:992-999
3. Alessi, D. R., Y. Saito, D. G. Campbell, P. Cohen, G. Sithanandara, U. Rapp, A. Ashwarth, C. J. Marshall, and S. Cowley. 1994. Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1. EMBO J. 13:1610-1619
4. Alvarez, E., I. C. Northwood, F. A. Gonzalez, D. A. Latour, A. Seth, C. Abate, T. Curran, and R. J. Davis. 1991. Pro-Leu-Ser/Thr-Pro is a consensus primary sequence for substrate protein phosphorylation Characterization of the phosphorylation of c-myc and c-jun proteins by an epidermal growth factor receptor threonine 669 protein kinase. J. Biol. Chem. 266:15277-15285.
5. Bagrodia, S., B. Derijard, R. J. Davis, and R. Cerione. 1995. Cdc42 and PAK-mediated signaling leads to JNK and p38 MAP kinase activation. J. Biol. Chem. 270:27995-27998.
6. Bleuis, J. 1993. Signal transduction via the MAP kinases: proceed at your own RSK. Proc. Natl. Acad Sci. USA 90:5889-5892.
7. Boulton, T. G., S. H. Nye, D. J. Robbins, N. Y. Ip, E. Radziejewska, S. D. Morgenbesser, R. A. DePinho, N. Panayotatos, M. H. Cobb, and G. D. Yancopoulos. 1991. ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell 65:663-675.
8. Boulton, T. G., G. D. Yancopoulos, J. S. Gregory, C. Slaughter, C. Moomaw, J. Hsu, and M. H. Cobb. 1990. An insulin-stimulated protein kinase similar to yeast kinases involved in cell cycle control. Science 249:64-67.
9. Brunet, A., G. Pages, and J. Pouyssegur. 1994. Constitutively active mutants of MAP kinase kinase (MEK1) induce growth factor-relaxation and oncogenicity when expressed in fibroblasts. Oncogene 9:3379-3387.
10. Cobb, M. H., J. E. Hepler, M. Cheng, and D. Robbins. 1994 The mitogen-activated protein kinases, ERK1 and ERK2 Semin Cancer Biol. 5:261-268.
11. Coso, O. A., M. Chiariello, J.-C. Yu, H. Teramoto, P. Crespo, N. Xu, T. Miki, and J. S. Gutkind. 1995. The small GTP-binding proteins rac1 and cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell 81:1137-1146.
12. Cowley, S., H. Paterson, P. Kemp, and C. J. Marshall. 1994. Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell 77:841-852.
13. Crews, C. M., and R. L. Erikson. 1993. Extracellular signals and reversible protein phosphorylation: what to Mek of it all. Cell 74:215-217.
14. Davis, R. J. 1993. The mitogen-activated protein kinase signal transduction pathway J. Biol. Chem. 268:14553-14556.
15. Davis, R. J. 1994. MAP kinases, new JNK expands the group Trends Biochem. Sci. 19:470-473.
16. Derijard, B., M. Hibi, I.-H. Wu, T. Barrett, B. Su, T. Deng, M. Kariu, and R. J. Davis. 1994 JNK1, a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 76:1025-1037
17. Dérijard, B., J. Raingeaud, T. Barrett, I.-H. Wu, J. Han, R. J. Ulevitch, and R. J. Davis. 1995. Independent human MAP kinase signal transduction pathways defined by MEK and MKK isoforms. Science 267:682-685.
18. Devary, Y., R. A. Gottlieb, T. Smeal, and M. Karin. 1992. The mammalian ultraviolet response is triggered by activation of Src tyrosine kinases. Cell 71:1081-1091.
19. English, J. M., C. A. Vanderbilt, S. Xu, S. Marcus, and M. H. Cobb. 1995. Isolation of MEK5 and differential expression of alternatively spliced forms. J. Biol. Chem. 270:28897-28902.
20. Freshney, N. W., L. Rawlinson, F. Guesdon, E. Jones, S. Cowley, J. Hsuan, and J. Saklatvala. 1994. Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27. Cell 78:1039-1049.
21. Gille, H., A. D. Sharrocks, and P. E. Shaw. 1992 Phosphorylation of transcription factor p62TCF by MAP kinase stimulates ternary complex formation at c-fos promoter. Nature (London) 358:414-417.
22. Gupta, S., T. Barrett, A. J. Whitmarsh, J. Cavanagh, and R. J. Davis. Selective interaction of JNK protein kinase isoforms with transcription factors. Submitted for publication.
23. Gupta, S., D. Campbell, B. Dérijard, and R. J. Davis. 1995. Transcription factor ATF2 regulation by the JNK signal transduction pathway. Science 267:389-393.
24. Gupta, S., A. Seth, and R. J. Davis. 1993. Transactivation of gene expression by Myc is inhibited by mutation at the phosphorylation sites Thr-58 and Ser-62. Proc. Natl. Acad. Sci. USA 90:3215-3220.
25. Hai, T., and T. Curran. 1991. Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity. Proc. Natl. Acad. Sci. USA 88:3720-3724.
26. Han, J., T. Brown, and B. Beutler. 1990. Endotoxin-responsive sequences control cachectin/tumor necrosis factor biosynthesis at the translational level. J. Exp. Med. 171:465-475.
27. Han, J., J.-D. Lee, L. Bibbs, and R. J. Ulevitch. 1994. A MAP kinase targeted bv endotoxin and hyperosmolarity in mammalian cells. Science 265:808-811.
28. Ho, S. N., H. D. Hunt, R. M. Horton, J. K. Pullen, and L. R. Pease. 1989. Site-directed mutagenesis by overlap extension using the polymerase chain reaction. Gene 77:51-59.
29. Huang, W., and R. L. Erikson. 1994 Constitutive activation of Mek1 by mutation of serine phosphorylation sites. Proc. Natl. Acad. Sci. USA 91: 8960-8963.
30. Janknecht, R., W. H. Ernst, V. Pingoud, and A. Nordheim. 1993. Activation of ternary complex factor Elk-1 by MAP kinases EMBO J. 12:5097-5104.
31. Kallunki, T., B. Su, I. Tsigelny, H. K. Sluss, B. Dérijard, G. Moore, R. J. Davis, and M. Karin. 1994. JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation. Genes Dev. 8:2996-3007
32. Kruys, V., K. Kemmer, A. Shakhov, V. Jongeneel, and B. Beutler. 1992. Constitutive activity of the tumor necrosis factor protomoter is canceled by the 3′ untranslated region in nonmacrophage cell lines, a transdominant factor overcomes this suppressive effect. Proc. Natl. Acad. Sci. USA 89:673-677.
33. Kruys, V., O. Marinx, G. Shaw, J. Deschamps, and G. Huez. 1989. Translational blockade imposed by cytokine-derived UA-rich sequences. Science 245:852-855
34. Kyriakis, J. M., P. Banerjee, E. Nikulakaki, T. Dai, E. A. Rubie, M. F. Ahmad, J. Avruch, and J. R. Woodgett. 1994. The stress-activated protein kinase subfamily of c-Jun kinases. Nature (London) 369:156-160.
35. Lee, J. C., J. T. Laydon, P. C. McDonnell, T. F. Gallagher, S. Kumar, D. Green, D. McNulty, M. J. Blumenthal, J. R. Heys, S. W. Landvatter, J. E. Strickler, M. M. McLaughlin, I. R. Siemens, S. M. Fisher, G. P. Livi, J. R. White, J. L. Adams, and P. R. Young. 1994. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis Nature (London) 372:739-746.
36. Lin, A., A. Minden, H. Martinetto, F.-X. Claret, C. Lange-Carter, F. Mercurio, G. L. Johnson, and M. Karin. 1995 Identification of a dual specificity kinase that activates Jun kinases and p38-Mpk2. Science 268:256-290.
37. Livingstone, C., G. Patel, and N. Jones. 1995. ATF-2 contains a phosphorylation-dependent transcriptional activation domain. EMBO J. 14:1785-1797.
38. Mansour, S. J., W. T. Marten, A. S. Hermann, J. M. Candia, S. Rong, K. Fukasawa, G. F. Vande Woude, and N. G. Ahn. 1994. Transformation of mammalian cells by constitutively activated MAP kinase kinase Science 265:966-970.
39. Marais, R., J. Wynne, and R. Treisman. 1993. The SRF accessory protein Elk-1 contains a growth factor regulated transcriptional activation domain. Cell 73:381-393.
40. Marshall, C. J. 1995. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80:179-185.
41. Minden, A., A. Lin, F.-X. Claret, A. Abo, and M. Karin. 1995 Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and cdc42Hs. Cell 81:1147-1157
42. Olson, M. F., A. Ashworth, and A. Hall. 1995 An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1. Science 269:1270-1272.
43. Pombo, C. M., J. H. Kehrl, I. Sanchez, P. Katz, J. Avruch, L. I. Zon, J. R. Woodgett, T. Force, and J. M. Kyriakis. 1995 Activation of the SAPK pathway by the human STE20 homologue germinal center kinase. Nature (London) 377:750-754.
44. Raingeaud, J., S. Gupta, J. Rogers, M. Dickens, J. Han, R. J. Ulevitch, and R. J. Davis. 1995. Pro-inflammatory cytokines and environmental stress cause p38 MAP kinase activation by dual phosphorylation on tyrosine and threonine. J. Biol. Chem. 270:7420-7426
45. Robbins, D. J., E. Zhen, M. Cheng, S. Xu, D. Ebert, and M. H. Cobb. 1994. MAP kinases ERK1 and ERK2: pleiotropic enzymes in a ubiquitous signaling network. Adv. Cancer Res. 63:93-116.
46. Robertson, L. M., T. K. Kerppola, M. Vendrell, D. Luk, R. J. Smeyne, C. Bocchiaro, J. I. Morgan, and T. Curran. 1995. Regulation of c-fos expression in transgenic mice requires multiple interdependent transcription control elements. Neuron 14:241-252.
47. Rouse, J., P. Cohen, S. Trigon, M. Morange, A. Alonso-Llamazares, D. Zamanillo, T. Hunt, and A. R. Nebreda. 1994. A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins. Cell 78:1027-1037
48. Sadowski, I., J. Ma, S. Triezenberg, and M. Ptashne. 1988. GAL4-VP16 is an unusually potent transcriptional activator. Nature (London) 335:563-564
49. Sadowski, I., and M. Ptashne. 1989. A vector for expressing GAL4(1-147) fusion proteins in mammalian cells. Nucleic Acids Res. 17:7539
50. Sanchez, I., R. T. Hughes, B. J. Mayer, K. Yee, J. R. Woodgett, J. Avruch, J. M. Kyriakis, and L. I. Zon. 1994, Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun. Nature (London) 372:794-798
51. Seger, R., D. Seger, F. J. Lozeman, N. G. Ahn, L. M. Graves, J. S. Campbell, L. Ericsson, M. Harrylock, A. M. Jensen, and E. G. Krebs. 1992. Human T-cell mitogen-activated protein kinase kinases are related to yeast signal transduction kinases. J. Biol. Chem. 267:25628-25631.
52. Seger, R., D. Seger, A. A. Reszka, E. S. Munar, H. Eldar-Finkelman, G. Dobrowolska, A. M. Jensen, J. S. Campbell, E. H. Fischer, and E. G. Krebs. 1994 Overexpression of mitogen-activated protein kinase kinase (MAPKK) and its mutants in NIH 3T3 cells. Evidence that MAPKK involvement in cellular proliferation is regulated by phosphorylation of serine residues in its kinase subdomains VII and VIII. J Biol. Chem. 269:25699-25709.
53. Seth, A., F. A. Gonzalez, S. Gupta, D. L. Raden, and R. J. Davis. 1992. Signal transduction within the nucleus by mitogen-activated protein kinase. J. Biol. Chem. 267:24796-24804.
54. Shaw, G., and R. Kamen. 1986. A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell 46:659-667.
55. Sluss, H. K., T. Barrett, B. Dérijard, and R. J. Davis. 1994. Signal transduction by tumor necrosis factor mediated by JNK protein kinases. Mol. Cell. Biol. 14:8376-8384.
56. Treisman, R. 1995 Differential activation of c-fos promoter elements by serum, lysophosphatidic acid, G proteins and polypeptide growth factors. EMBO J. 14:5037-5047.
57. van Dam, H., M. Duyndam, R. Rottier, A. Bosch, L. de Vries-Smits, P. Herrlich, A. Zantema, P. Angel, and A. J. van der Eb. 1993. Heterodimer formation of c-Jun and ATF-2 is responsible for induction of c-Jun by the 243 ammo acid adenovirus E1A protein. EMBO J. 12:479-487.
58. van Dam, H., D. Wilhelm, I. Herr, A. Steffen, P. Herrlich, and P. Angel. 1995. ATF2 is preferentially activated by stress-activated protein kinases to mediate c-Jun induction in response to genotoxic agents. EMBO J. 14:1798-1811.
59. Wagner, S., and M. R. Green. 1993. HTLV-I Tax protein stimulation of DNA binding of bZIP proteins by enhancing dimerization Science 262:395-399.
60. Whitmarsh, A. J., P. Shore, A. D. Sharrocks, and R. J. Davis. 1995. Integration of MAP kinase signal transduction pathways at the serum response element. Science 269:403-407.
61. Xia, Z., M. Dickens, J. Raingeaud, R. J. Davis, and M. E. Greenberg. 1995. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis Science 270:1326-1331.
62. Zhang, S., J. Han, M.-A. Sells, J. Chernoff, U. G. Knaus, R. J. Ulevitch, and G. M. Bokoch. 1995. Rho family GTPases regulate p38 mitogen-activated protein kinase through the down-stream mediator PAK-1. J. Biol. Chem. 270:23934-23936.
63. Zheng, C. F., and K. L. Guan. 1993. Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2. J. Biol. Chem. 268:11435-11439
64. Zheng, C. F., and K. L. Guan. 1994. Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues EMBO J 13: 1123-1131.
65. Zhou, G., Z. Q. Bao, and J. E. Dixon. 1995. Components of a new human protein kinase signal transduction pathway. J Biol. Chem. 270:12665-12669.