Signalling adaptors used by Toll-like receptors: An update

Cytokine

Volumn 43, Issue 3, 2008, Pages 342-349

  Kenny, Elaine F ^a   O'Neill, Luke A J ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

Mal; MyD88; Toll like receptor; Toll IL1 receptor domain; TRAM

Indexed keywords

ADAPTOR PROTEIN; ALUMINUM POTASSIUM SULFATE; BETA INTERFERON; INTERFERON REGULATORY FACTOR 3; INTERLEUKIN 1 RECEPTOR; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MYELOID DIFFERENTIATION FACTOR 88; PROTEIN KINASE B; PROTEIN KINASE C EPSILON; PROTEIN SARM; PROTEIN TRAM; PROTEIN TRIF; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TYROSINE; UNCLASSIFIED DRUG;

BRAIN TOXICITY; CARCINOGENESIS; ENDOSOME; ENZYME ACTIVATION; INNATE IMMUNITY; LIVER CELL CARCINOMA; MYRISTYLATION; NONHUMAN; OXIDATIVE STRESS; POLYPOSIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; ARMADILLO DOMAIN PROTEINS; CASPASE 1; CYTOSKELETAL PROTEINS; ENDOSOMES; HUMANS; MEMBRANE GLYCOPROTEINS; MICE; MYELOID DIFFERENTIATION FACTOR 88; PROTEIN KINASE C-EPSILON; RECEPTORS, INTERLEUKIN-1; TOLL-LIKE RECEPTOR 3; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS;

EID: 51349158231     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cyto.2008.07.010     Document Type: Review

References (40)

1. Akira S., Yamamoto M., and Takeda K. Role of adapters in Toll-like receptor signalling. Biochem Soc Trans 31 Pt. 3 (2003) 637-642
2. O'Neill L.A., Fitzgerald K.A., and Bowie A.G. The Toll-IL-1 receptor adaptor family grows to five members. Trends Immunol 24 6 (2003) 286-290
3. McGettrick A.F., and O'Neill L.A. The expanding family of MyD88-like adaptors in Toll-like receptor signal transduction. Mol Immunol 41 6-7 (2004) 577-582
4. Oda K., and Kitano H. A comprehensive map of the Toll-like receptor signaling network. Mol Syst Biol 2 (2006) 0015
5. O'Neill L.A., and Bowie A.G. The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat Rev Immunol 7 5 (2007) 353-364
6. Kawai T., and Akira S. TLR signaling. Cell Death Differ 13 5 (2006) 816-825
7. Medzhitov R., Preston-Hurlburt P., Kopp E., Stadlen A., Chen C., Ghosh S., et al. MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol Cell 2 2 (1998) 253-258
8. Davis C.N., Mann E., Behrens M.M., Gaidarova S., Rebek M., Rebek Jr. J., et al. MyD88-dependent and -independent signaling by IL-1 in neurons probed by bifunctional Toll/IL-1 receptor domain/BB-loop mimetics. Proc Natl Acad Sci USA 103 8 (2006) 2953-2958
9. Adachi O., Kawai T., Takeda K., Matsumoto M., Tsutsui H., Sakagami M., et al. Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity 9 1 (1998) 143-150
10. Davis C.N., Tabarean I., Gaidarova S., Behrens M.M., and Bartfai T. IL-1beta induces a MyD88-dependent and ceramide-mediated activation of Src in anterior hypothalamic neurons. J Neurochem 98 5 (2006) 1379-1389
11. Eisenbarth S.C., Colegio O.R., O'Connor W., Sutterwala F.S., and Flavell R.A. Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants. Nature 453 7198 (2008) 1122-1126
12. Castrillo A., Pennington D.J., Otto F., Parker P.J., Owen M.J., and Bosca L. Protein kinase Cepsilon is required for macrophage activation and defense against bacterial infection. J Exp Med 194 9 (2001) 1231-1242
13. McGettrick A.F., Brint E.K., Palsson-McDermott E.M., Rowe D.C., Golenbock D.T., Gay N.J., et al. Trif-related adapter molecule is phosphorylated by PKC{epsilon} during Toll-like receptor 4 signaling. Proc Natl Acad Sci USA 103 24 (2006) 9196-9201
14. Faisal A., Saurin A., Gregory B., Foxwell B., and Parker P.J. The scaffold MYD88 acts to couple protein kinase C epsilon (PKCepsilon) to Toll-like receptors. J Biol Chem 283 (2008) 18591-18600
15. Durgan J., Cameron A.J., Saurin A.T., Hanrahan S., Totty N., Messing R.O., et al. The identification and characterization of novel PKCepsilon phosphorylation sites provide evidence for functional cross-talk within the PKC superfamily. Biochem J 411 2 (2008) 319-331
16. Oshiumi H., Sasai M., Shida K., Fujita T., Matsumoto M., and Seya T. TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to Toll-like receptor 4 TICAM-1 that induces interferon-beta. J Biol Chem 278 50 (2003) 49751-49762
17. Johnson A.C., Li X., and Pearlman E. MyD88 functions as a negative regulator of TLR3/TRIF-induced corneal inflammation by inhibiting activation of c-Jun N-terminal kinase. J Biol Chem 283 7 (2008) 3988-3996
18. Rakoff-Nahoum S., and Medzhitov R. Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Science 317 5834 (2007) 124-127
19. Naugler W.E., Sakurai T., Kim S., Maeda S., Kim K., Elsharkawy A.M., et al. Gender disparity in liver cancer due to sex differences in MyD88-dependent IL-6 production. Science 317 5834 (2007) 121-124
20. Rhee SH, Im E, Pothoulakis C. Toll-like receptor 5 engagement modulates tumor development and growth in a mouse xenograft model of human colon cancer. Gastroenterology 2008; in press. doi:10.1053/j.gastro.2008.04.022.
21. Yamamoto M., Sato S., Hemmi H., Sanjo H., Uematsu S., Kaisho T., et al. Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4. Nature 420 6913 (2002) 324-329
22. Dunne A., Ejdeback M., Ludidi P.L., O'Neill L.A., and Gay N.J. Structural complementarity of Toll/interleukin-1 receptor domains in Toll-like receptors and the adaptors Mal and MyD88. J Biol Chem 278 42 (2003) 41443-41451
23. Miggin S.M., Palsson-McDermott E., Dunne A., Jefferies C., Pinteaux E., Banahan K., et al. NF-kappaB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1. Proc Natl Acad Sci USA 104 9 (2007) 3372-3377
24. Castiblanco J, Varela DC, Castano-Rodriguez N, Rojas-Villarraga A, Hincapie ME, Anaya JM. TIRAP (MAL) S180L polymorphism is a common protective factor against developing tuberculosis and systemic lupus erythematosus. Infect Genet Evol 2008; in press. doi:10.1016/j.meegid.2008.03.001.
25. Nejentsev S., Thye T., Szeszko J.S., Stevens H., Balabanova Y., Chinbuah A.M., et al. Analysis of association of the TIRAP (MAL) S180L variant and tuberculosis in three populations. Nat Genet 40 3 (2008) 261-262 (author reply 2-3)
26. Sheedy FJ, Marinou I, O'Neill LA, Wilson AG. The Mal/TIRAP S180L and TLR4 G299D polymorphisms are not associated with susceptibility to or severity of rheumatoid arthritis. Ann Rheum Dis 2008; in press. doi:10.1136/ard.2007.083337.
27. Cantaert T., Stone M.A., ter Borg M., Mogg R., De Vries N., Wilson A.G., et al. A functional polymorphism of TIR-domain-containing adaptor protein is not associated with axial spondyloarthritis. Ann Rheum Dis 67 5 (2008) 720-722
28. Gray P., Dunne A., Brikos C., Jefferies C.A., Doyle S.L., and O'Neill L.A. MyD88 adapter-like (Mal) is phosphorylated by Bruton's tyrosine kinase during TLR2 and TLR4 signal transduction. J Biol Chem 281 15 (2006) 10489-10495
29. Piao W., Song C., Chen H., Wahl L.M., Fitzgerald K.A., O'Neill L.A., et al. Tyrosine phosphorylation of MyD88 adapter-like (Mal) is critical for signal transduction and blocked in endotoxin tolerance. J Biol Chem 283 6 (2008) 3109-3119
30. Yamamoto M., Sato S., Hemmi H., Hoshino K., Kaisho T., Sanjo H., et al. Role of adaptor TRIF in the MyD88-independent Toll-like receptor signaling pathway. Science 301 5633 (2003) 640-643
31. Covert M.W., Leung T.H., Gaston J.E., and Baltimore D. Achieving stability of lipopolysaccharide-induced NF-kappaB activation. Science 309 5742 (2005) 1854-1877
32. Biswas S.K., Bist P., Dhillon M.K., Kajiji T., Del Fresno C., Yamamoto M., et al. Role for MyD88-independent, TRIF pathway in lipid A/TLR4-induced endotoxin tolerance. J Immunol 179 6 (2007) 4083-4092
33. Kumar H., Koyama S., Ishii K.J., Kawai T., and Akira S. Cutting edge: cooperation of IPS-1- and TRIF-dependent pathways in poly IC-enhanced antibody production and cytotoxic T cell responses. J Immunol 180 2 (2008) 683-687
34. Rowe D.C., McGettrick A.F., Latz E., Monks B.G., Gay N.J., Yamamoto M., et al. The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction. Proc Natl Acad Sci USA 103 16 (2006) 6299-6304
35. Nunez Miguel R., Wong J., Westoll J.F., Brooks H.J., O'Neill L.A., Gay N.J., et al. A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins. PLoS One 2 8 (2007) e788
36. Tanimura N., Saitoh S., Matsumoto F., Akashi-Takamura S., and Miyake K. Roles for LPS-dependent interaction and relocation of TLR4 and TRAM in TRIF-signaling. Biochem Biophys Res Commun 368 1 (2008) 94-99
37. Kagan J.C., Su T., Horng T., Chow A., Akira S., and Medzhitov R. TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nat Immunol 9 4 (2008) 361-368
38. Liberati N.T., Fitzgerald K.A., Kim D.H., Feinbaum R., Golenbock D.T., and Ausubel F.M. Requirement for a conserved Toll/interleukin-1 resistance domain protein in the Caenorhabditis elegans immune response. Proc Natl Acad Sci USA 101 17 (2004) 6593-6598
39. Carty M., Goodbody R., Schroder M., Stack J., Moynagh P.N., and Bowie A.G. The human adaptor SARM negatively regulates adaptor protein TRIF-dependent Toll-like receptor signaling. Nat Immunol 7 10 (2006) 1074-1081
40. Kim Y., Zhou P., Qian L., Chuang J.Z., Lee J., Li C., et al. MyD88-5 links mitochondria, microtubules, and JNK3 in neurons and regulates neuronal survival. J Exp Med 204 9 (2007) 2063-2074