A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation

Journal of Biological Chemistry

Volumn 272, Issue 47, 1997, Pages 29911-29918

  Paz, Keren ^a   Hemi, Rina ^b   LeRoith, Derek ^c   Karasik, Avraham ^b   Elhanany, Eytan ^d   Kanety, Hannah ^b   Zick, Yehiel ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b SHEBA MEDICAL CENTER   (Israel)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d ISRAEL INSTITUTE FOR BIOLOGICAL RESEARCH   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; BACTERIAL ENZYME; CELL EXTRACT; HYBRID PROTEIN; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; SERINE; SPHINGOMYELIN PHOSPHODIESTERASE; THREONINE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; HEPATOMA CELL; HORMONE ACTION; INSULIN BINDING; INSULIN RESISTANCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; BINDING SITES; ENZYME INHIBITORS; HUMANS; INSULIN; INSULIN RESISTANCE; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; OKADAIC ACID; OXAZOLES; PHOSPHOPROTEIN PHOSPHATASE; PHOSPHOPROTEINS; PHOSPHORYLATION; RATS; RECEPTOR, INSULIN; SPHINGOMYELIN PHOSPHODIESTERASE; TUMOR NECROSIS FACTOR-ALPHA; TYROSINE;

ANIMALIA; APOGON BRACHYGRAMMUS; BACTERIA (MICROORGANISMS);

EID: 0030669392     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.47.29911     Document Type: Article

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