메뉴 건너뛰기




Volumn 16, Issue 2, 1997, Pages 295-305

Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); Comparison of the specificities of SAPK3 and SAPK2 (RK/p38)

Author keywords

IL 1; MAP kinase kinase; MEK; Stress; TNF

Indexed keywords

CYTOKINE; INTERLEUKIN 1; MITOGEN ACTIVATED PROTEIN KINASE; SERINE; THREONINE; TRANSCRIPTION FACTOR; TUMOR NECROSIS FACTOR;

EID: 0031024646     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/16.2.295     Document Type: Article
Times cited : (321)

References (61)
  • 1
    • 0028884033 scopus 로고
    • PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
    • Alessi, D.R., Cuenda, A., Cohen, P., Dudley, D.T. and Saltiel, A.R. (1995a) PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J. Biol. Chem., 270, 27489-27494.
    • (1995) J. Biol. Chem. , vol.270 , pp. 27489-27494
    • Alessi, D.R.1    Cuenda, A.2    Cohen, P.3    Dudley, D.T.4    Saltiel, A.R.5
  • 4
    • 0028806565 scopus 로고
    • Identification of novel phosphorylation sites required for the activation of MAPKAP kinase- 2
    • Ben-Levy, R., Leighton, I.A., Doza, Y.N., Morrice, N., Attwood, P., Marshall, C.J. and Cohen, P. (1995) Identification of novel phosphorylation sites required for the activation of MAPKAP kinase-2. EMBO J., 14, 101-110.
    • (1995) EMBO J. , vol.14 , pp. 101-110
    • Ben-Levy, R.1    Leighton, I.A.2    Doza, Y.N.3    Morrice, N.4    Attwood, P.5    Marshall, C.J.6    Cohen, P.7
  • 5
    • 0029983730 scopus 로고    scopus 로고
    • The p38/RK mitogen- Activated protein kinase pathway regulates interleukin-6 synthesis in response to tumour necrosis factor
    • Beyaert, R., Cuenda, A., Vanden Berghe, W., Plaisance, S., Lee, J.C., Haegeman, G., Cohen, P. and Fiers, W. (1996) The p38/RK mitogen-activated protein kinase pathway regulates interleukin-6 synthesis in response to tumour necrosis factor. EMBO J., 15, 1914-1923.
    • (1996) EMBO J. , vol.15 , pp. 1914-1923
    • Beyaert, R.1    Cuenda, A.2    Vanden Berghe, W.3    Plaisance, S.4    Lee, J.C.5    Haegeman, G.6    Cohen, P.7    Fiers, W.8
  • 6
    • 0029913457 scopus 로고    scopus 로고
    • Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3
    • Blank, J.L., Gerwins, P., Elliot, E.M., Sather, S. and Johnson, G.L. (1996) Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. J. Biol. Chem., 271, 5361-5368.
    • (1996) J. Biol. Chem. , vol.271 , pp. 5361-5368
    • Blank, J.L.1    Gerwins, P.2    Elliot, E.M.3    Sather, S.4    Johnson, G.L.5
  • 7
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein- Dye binding
    • Bradford, M.M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72, 248-254.
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 8
    • 0028793798 scopus 로고
    • Induction of c- Fos expression through JNK-mediated TCF/Elk1 phosphorylation
    • Cavigelli, M., Dolfi, F., Claret, F.-X. and Karin, M. (1995) Induction of c-fos expression through JNK-mediated TCF/Elk1 phosphorylation. EMBO J., 14, 5957-5964.
    • (1995) EMBO J. , vol.14 , pp. 5957-5964
    • Cavigelli, M.1    Dolfi, F.2    Claret, F.-X.3    Karin, M.4
  • 9
    • 0030565457 scopus 로고    scopus 로고
    • A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress
    • Clifton, A.D., Young, P.R. and Cohen, P. (1996) A comparison of the substrate specificity of MAPKAP kinase-2 and MAPKAP kinase-3 and their activation by cytokines and cellular stress. FEBS Lett., 392, 209-214.
    • (1996) FEBS Lett. , vol.392 , pp. 209-214
    • Clifton, A.D.1    Young, P.R.2    Cohen, P.3
  • 10
    • 0011250170 scopus 로고    scopus 로고
    • Dissection of stress and cytokine-activated kinase cascades: The advent of specific inhibitors
    • in press
    • Cohen, P. (1997) Dissection of stress and cytokine-activated kinase cascades: the advent of specific inhibitors. Trends Cell Biol., in press.
    • (1997) Trends Cell Biol.
    • Cohen, P.1
  • 11
    • 0028988138 scopus 로고
    • SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1
    • Cuenda, A., Rouse, J., Doza, Y.N., Meier, R., Cohen, P., Gallagher, T.F., Young, P.R. and Lee, J.C. (1995) SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett., 364, 229-233.
    • (1995) FEBS Lett. , vol.364 , pp. 229-233
    • Cuenda, A.1    Rouse, J.2    Doza, Y.N.3    Meier, R.4    Cohen, P.5    Gallagher, T.F.6    Young, P.R.7    Lee, J.C.8
  • 12
    • 0029782176 scopus 로고    scopus 로고
    • Purification and cDNA cloning of SAPKK3, the major activator of RK/p38 in stress- and cytokine-stimulated monocytes and epithelial cells
    • Cuenda, A., Alonso, G., Morrice, N., Jones, M., Meier, R., Cohen, P. and Nebreda, A.R. (1996) Purification and cDNA cloning of SAPKK3, the major activator of RK/p38 in stress- and cytokine-stimulated monocytes and epithelial cells. EMBO J., 15, 4156-4164.
    • (1996) EMBO J. , vol.15 , pp. 4156-4164
    • Cuenda, A.1    Alonso, G.2    Morrice, N.3    Jones, M.4    Meier, R.5    Cohen, P.6    Nebreda, A.R.7
  • 13
    • 0028329953 scopus 로고
    • JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
    • Dérijard, B., Hibi, M., Wu, I.-H., Barrett, T., Su, B., Deng, T., Karin, M. and Davis, R.J. (1994) JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell, 76, 1025-1037.
    • (1994) Cell , vol.76 , pp. 1025-1037
    • Dérijard, B.1    Hibi, M.2    Wu, I.-H.3    Barrett, T.4    Su, B.5    Deng, T.6    Karin, M.7    Davis, R.J.8
  • 14
    • 0028935974 scopus 로고
    • Independent human MAP kinase signal transduction pathways defined by MEK and MKK isofomns
    • Dérijard, B., Raingeaud, J., Barrett, T., Wu, I.-H., Han, J., Ulevitch, R.J. and Davis, R.J. (1995) Independent human MAP kinase signal transduction pathways defined by MEK and MKK isofomns. Science, 267, 682-684.
    • (1995) Science , vol.267 , pp. 682-684
    • Dérijard, B.1    Raingeaud, J.2    Barrett, T.3    Wu, I.-H.4    Han, J.5    Ulevitch, R.J.6    Davis, R.J.7
  • 15
    • 0028969480 scopus 로고
    • Activation of the MAP kinase homologue RK requires the phosphorylation of Thr-180 and Tyr-182 and both residues are phosphorylated in chemically stressed KB cells
    • Doza, Y.N., Cuenda, A., Thomas, G.M., Cohen, P. and Nebreda, A.R. (1995) Activation of the MAP kinase homologue RK requires the phosphorylation of Thr-180 and Tyr-182 and both residues are phosphorylated in chemically stressed KB cells. FEBS Lett., 364, 223-228.
    • (1995) FEBS Lett. , vol.364 , pp. 223-228
    • Doza, Y.N.1    Cuenda, A.2    Thomas, G.M.3    Cohen, P.4    Nebreda, A.R.5
  • 16
    • 0028015872 scopus 로고
    • Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of hsp27
    • Freshney, N.W., Rawlinson, L., Guesdon, F., Jones, E., Cowley, S., Hsuan, J. and Saklatvala, J. (1994) Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of hsp27. Cell, 78, 1039-1049.
    • (1994) Cell , vol.78 , pp. 1039-1049
    • Freshney, N.W.1    Rawlinson, L.2    Guesdon, F.3    Jones, E.4    Cowley, S.5    Hsuan, J.6    Saklatvala, J.7
  • 17
    • 0028338460 scopus 로고
    • Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB
    • Ginty, D.D., Bonni, A. and Greenberg, M.E. (1994) Nerve growth factor activates a Ras-dependent protein kinase that stimulates c-fos transcription via phosphorylation of CREB. Cell, 77, 713-725.
    • (1994) Cell , vol.77 , pp. 713-725
    • Ginty, D.D.1    Bonni, A.2    Greenberg, M.E.3
  • 18
    • 0028860586 scopus 로고
    • The activation of distinct mitogen-activated protein kinase cascades is required for the stimulation of 2-deoxyglucose uptake by interleukin-1 and insulin-like growth factor-1 in KB cells
    • Gould, G.W., Cuenda, A., Thomson, F.J. and Cohen, P. (1995) The activation of distinct mitogen-activated protein kinase cascades is required for the stimulation of 2-deoxyglucose uptake by interleukin-1 and insulin-like growth factor-1 in KB cells. Biochem. J., 311, 735-738.
    • (1995) Biochem. J. , vol.311 , pp. 735-738
    • Gould, G.W.1    Cuenda, A.2    Thomson, F.J.3    Cohen, P.4
  • 19
    • 0028905076 scopus 로고
    • Transcription factor ATF2 regulation by the JNK signal transduction pathway
    • Gupta, S., Campbell, D., Dérijard, B. and Davis, R.J. (1995) Transcription factor ATF2 regulation by the JNK signal transduction pathway. Science, 267, 389-393.
    • (1995) Science , vol.267 , pp. 389-393
    • Gupta, S.1    Campbell, D.2    Dérijard, B.3    Davis, R.J.4
  • 20
    • 0027936755 scopus 로고
    • A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells
    • Han, J., Lee, J.D., Bibbs, L. and Ulevitch, R.J. (1994) A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science, 265, 808-811.
    • (1994) Science , vol.265 , pp. 808-811
    • Han, J.1    Lee, J.D.2    Bibbs, L.3    Ulevitch, R.J.4
  • 21
    • 0030044182 scopus 로고    scopus 로고
    • Characterization of the structure and function of a novel MAP kinase kinase (MKK6)
    • Han, J., Lee, J.D., Jiang, Y., Li, Z., Feng, L. and Ulevitch, R.J. (1996) Characterization of the structure and function of a novel MAP kinase kinase (MKK6). J. Biol. Chem., 271, 2886-2891.
    • (1996) J. Biol. Chem. , vol.271 , pp. 2886-2891
    • Han, J.1    Lee, J.D.2    Jiang, Y.3    Li, Z.4    Feng, L.5    Ulevitch, R.J.6
  • 23
    • 0029617851 scopus 로고
    • Protein phosphatase 1 interacts with p53BP2, a protein which binds to the tumour suppressor p53
    • Helps, N.R., Barker, H.Z., Elledge, S.J. and Cohen, P.T.W. (1995) Protein phosphatase 1 interacts with p53BP2, a protein which binds to the tumour suppressor p53. FEBS Lett., 377, 295-300.
    • (1995) FEBS Lett. , vol.377 , pp. 295-300
    • Helps, N.R.1    Barker, H.Z.2    Elledge, S.J.3    Cohen, P.T.W.4
  • 24
    • 0027423418 scopus 로고
    • Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain
    • Hibi, M., Lin, A., Smeal, T., Minden, A. and Karin, M. (1993) Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev., 7, 2135-2148.
    • (1993) Genes Dev. , vol.7 , pp. 2135-2148
    • Hibi, M.1    Lin, A.2    Smeal, T.3    Minden, A.4    Karin, M.5
  • 25
    • 0030024707 scopus 로고    scopus 로고
    • Activation of the JNK pathway by distantly related protein kinases, MEKK and MUK
    • Hirai, S.-I., Izawa, M. Osada, S.-I., Spyrou, G. and Ohno, S. (1996) Activation of the JNK pathway by distantly related protein kinases, MEKK and MUK. Oncogene, 12, 641-650.
    • (1996) Oncogene , vol.12 , pp. 641-650
    • Hirai, S.-I.1    Izawa, M.2    Osada, S.-I.3    Spyrou, G.4    Ohno, S.5
  • 26
    • 0028832107 scopus 로고
    • Characterization of 45-kDa/54-kDa HSP27 kinase. a stress-sensitive kinase which may activate the phosphorylation-dependem protective function of mammalian 27-kDa heat shock protein HSP27
    • Huot, J., Lambert, H., Lavoie, J.N., Guimond, A., Houle, F. and Landry, J. (1995) Characterization of 45-kDa/54-kDa HSP27 kinase. a stress-sensitive kinase which may activate the phosphorylation-dependem protective function of mammalian 27-kDa heat shock protein HSP27. Eur. J. Biochem., 227, 416-427.
    • (1995) Eur. J. Biochem. , vol.227 , pp. 416-427
    • Huot, J.1    Lambert, H.2    Lavoie, J.N.3    Guimond, A.4    Houle, F.5    Landry, J.6
  • 27
    • 0029982565 scopus 로고    scopus 로고
    • Characterisation of the structure and function of a new mitogen activated protein kinase (p38β)
    • Jiang, Y. Chen, C. U.Z., Guo, W., Gegner, J.A., Lin, S. and Han, J. (1996) Characterisation of the structure and function of a new mitogen activated protein kinase (p38β). J. Biol. Chem., 271, 17920-17926.
    • (1996) J. Biol. Chem. , vol.271 , pp. 17920-17926
    • Jiang, Y.1    Chen, C.U.Z.2    Guo, W.3    Gegner, J.A.4    Lin, S.5    Han, J.6
  • 29
    • 0028924759 scopus 로고
    • Modulation of cellular thermoresistance and actin filament stability accompanies phosphorylation-induced changes in the oligomeric structure of heat shock protein 27
    • Lavoie, J.N., Lambert, H., Hickey, E., Weber, L.A. and Landry, J. (1995) Modulation of cellular thermoresistance and actin filament stability accompanies phosphorylation-induced changes in the oligomeric structure of heat shock protein 27. Mol. Cell. Biol., 15, 505-516.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 505-516
    • Lavoie, J.N.1    Lambert, H.2    Hickey, E.3    Weber, L.A.4    Landry, J.5
  • 30
    • 0029911710 scopus 로고    scopus 로고
    • ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation
    • Lechner, C. Zahalka, M.A., Giot, J.-F., Moller, M.P. and Ullrich, A. (1996) ERK6, a mitogen-activated protein kinase involved in C2C12 myoblast differentiation. Proc. Natl Acad. Sci. USA, 93, 4355-4359.
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 4355-4359
    • Lechner, C.1    Zahalka, M.A.2    Giot, J.-F.3    Moller, M.P.4    Ullrich, A.5
  • 31
    • 0028605318 scopus 로고
    • A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
    • Lee, J.C. et al. (1994) A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature, 372, 739-746.
    • (1994) Nature , vol.372 , pp. 739-746
    • Lee, J.C.1
  • 33
    • 0029034251 scopus 로고
    • ATF-2 contains a phosphorylation-dependent transcriptional activation domain
    • Livingstone, C., Patel, G. and Jones, N. (1995) ATF-2 contains a phosphorylation-dependent transcriptional activation domain. EMBO J., 14, 1785-1797.
    • (1995) EMBO J. , vol.14 , pp. 1785-1797
    • Livingstone, C.1    Patel, G.2    Jones, N.3
  • 35
    • 0029923193 scopus 로고    scopus 로고
    • Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase
    • McLaughlin, M.M., Kumar, S., McDonnell, P.C. Van Horn, S., Lee, J.C. Livi, G.P. and Young, P.R. (1996) Identification of mitogen-activated protein (MAP) kinase-activated protein kinase-3, a novel substrate of CSBP p38 MAP kinase. J. Biol. Chem., 271, 8488-8492.
    • (1996) J. Biol. Chem. , vol.271 , pp. 8488-8492
    • McLaughlin, M.M.1    Kumar, S.2    McDonnell, P.C.3    Van Horn, S.4    Lee, J.C.5    Livi, G.P.6    Young, P.R.7
  • 36
    • 0029930461 scopus 로고    scopus 로고
    • Cellular stresses and cytokines activate multiple mitogen-activated protein kinase kinase homologues in PC12 and KB cells
    • Meier, R., Rouse, J., Cuenda, A., Nebreda, A.R. and Cohen, P. (1996) Cellular stresses and cytokines activate multiple mitogen-activated protein kinase kinase homologues in PC12 and KB cells. Eur. J. Biochem., 236, 796-805.
    • (1996) Eur. J. Biochem. , vol.236 , pp. 796-805
    • Meier, R.1    Rouse, J.2    Cuenda, A.3    Nebreda, A.R.4    Cohen, P.5
  • 37
    • 0029913458 scopus 로고    scopus 로고
    • SAP kinase-3, a new member of the family of mammalian stress-activated protein kinases
    • Mertens, S., Craxton, M. and Goedert, M. (1996) SAP kinase-3, a new member of the family of mammalian stress-activated protein kinases. FEBS Lett., 383, 273-276.
    • (1996) FEBS Lett. , vol.383 , pp. 273-276
    • Mertens, S.1    Craxton, M.2    Goedert, M.3
  • 38
  • 39
    • 15844431960 scopus 로고    scopus 로고
    • A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3
    • Moriguchi, T. et al. (1996) A novel kinase cascade mediated by mitogen-activated protein kinase kinase 6 and MKK3. J. Biol. Chem., 271, 13675-13679.
    • (1996) J. Biol. Chem. , vol.271 , pp. 13675-13679
    • Moriguchi, T.1
  • 40
    • 0029101360 scopus 로고
    • An essential role for Rho. Rac and CDC42 GTPases in cell-cycle progression through Gl
    • Olson, N.F., Ashworth, A. and Hall, A. (1995) An essential role for Rho. Rac and CDC42 GTPases in cell-cycle progression through Gl. Science, 269, 1270-1272.
    • (1995) Science , vol.269 , pp. 1270-1272
    • Olson, N.F.1    Ashworth, A.2    Hall, A.3
  • 41
    • 0343996759 scopus 로고    scopus 로고
    • Involvement of MAP kinase homologues in lipopolysaccharide-mediated induction of cyclo-oxygenase-2 and nitric synthase and the inhibition of cellular apoptosis
    • in press
    • Paul, A., Cuenda, A., Bryant, C.E., Murray, J., Chilvers, E.R., Cohen, P., Gould, G.W. and Plevin, R. (1997) Involvement of MAP kinase homologues in lipopolysaccharide-mediated induction of cyclo-oxygenase-2 and nitric synthase and the inhibition of cellular apoptosis. FEBS Lett., in press.
    • (1997) FEBS Lett.
    • Paul, A.1    Cuenda, A.2    Bryant, C.E.3    Murray, J.4    Chilvers, E.R.5    Cohen, P.6    Gould, G.W.7    Plevin, R.8
  • 42
    • 0029827366 scopus 로고    scopus 로고
    • The p38 and ERK MAP kinase pathways cooperate to activate Ternary Complex Factors and c-fos transcription in response to UV light
    • Price, M.A. and Treisman, R. (1996) The p38 and ERK MAP kinase pathways cooperate to activate Ternary Complex Factors and c-fos transcription in response to UV light. EMBO J., 15, 6552-6563.
    • (1996) EMBO J. , vol.15 , pp. 6552-6563
    • Price, M.A.1    Treisman, R.2
  • 44
    • 0030051528 scopus 로고    scopus 로고
    • MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway
    • Raingeaud, J., Whitmarsh, A.J., Barret, T. Dérijard, B. and Davis, R.J. (1996) MKK3- and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway. Mol. Cell. Biol., 16, 1247-1255.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 1247-1255
    • Raingeaud, J.1    Whitmarsh, A.J.2    Barret, T.3    Dérijard, B.4    Davis, R.J.5
  • 45
    • 0029760613 scopus 로고    scopus 로고
    • The mixed lineage kinase SPRK phosphorylates and activates the stress-activated protein kinase activator, SEK1
    • Rana, A., Gallo, K., Godowski, B., Hirai, S.I., Ohno, S., Zon, L., Kyriakis, J.M. and Avruch, J. (1996) The mixed lineage kinase SPRK phosphorylates and activates the stress-activated protein kinase activator, SEK1. J. Biol Chem., 271, 19025-19028.
    • (1996) J. Biol Chem. , vol.271 , pp. 19025-19028
    • Rana, A.1    Gallo, K.2    Godowski, B.3    Hirai, S.I.4    Ohno, S.5    Zon, L.6    Kyriakis, J.M.7    Avruch, J.8
  • 46
    • 0028022750 scopus 로고
    • A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins
    • Rouse, J., Cohen, P., Trigon, S., Morange, M., Alonso-Llamazares, A., Zamanillo, D., Hunt, T. and Nebreda, A. (1994) A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins. Cell, 78, 1027-1037.
    • (1994) Cell , vol.78 , pp. 1027-1037
    • Rouse, J.1    Cohen, P.2    Trigon, S.3    Morange, M.4    Alonso-Llamazares, A.5    Zamanillo, D.6    Hunt, T.7    Nebreda, A.8
  • 48
    • 0030059508 scopus 로고    scopus 로고
    • Activation of MEK-1 and SEK-1 by Tpl-2 protooncoprotein, a novel MAP kinase kinase kinase
    • Salmeron, A., Ahmad, T.B., Carlile, G.W., Pappin, D., Narsimhan, R.P. and Ley, S.C. (1996) Activation of MEK-1 and SEK-1 by Tpl-2 protooncoprotein, a novel MAP kinase kinase kinase. EMBO J., 15, 817-826.
    • (1996) EMBO J. , vol.15 , pp. 817-826
    • Salmeron, A.1    Ahmad, T.B.2    Carlile, G.W.3    Pappin, D.4    Narsimhan, R.P.5    Ley, S.C.6
  • 49
    • 0028558986 scopus 로고
    • Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun
    • Sanchez, I., Hughes, R.T., Mayer, B.J., Yee, K., Woodgett, J.R., Avruch, J., Kyriakis, J.M. and Zon, L.I. (1994) Role of SAPK/ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun. Nature, 372, 794-798.
    • (1994) Nature , vol.372 , pp. 794-798
    • Sanchez, I.1    Hughes, R.T.2    Mayer, B.J.3    Yee, K.4    Woodgett, J.R.5    Avruch, J.6    Kyriakis, J.M.7    Zon, L.I.8
  • 50
    • 0030006618 scopus 로고    scopus 로고
    • Cloning and characterisation of MEK6, a novel member of the mitogen-activated protein kinase kinase cascade
    • Stein, B., Brady, H., Yang, M.X., Young, D.B. and Barbosa, M.S. (1996) Cloning and characterisation of MEK6, a novel member of the mitogen-activated protein kinase kinase cascade. J. Biol. Chem., 271, 11427-11433.
    • (1996) J. Biol. Chem. , vol.271 , pp. 11427-11433
    • Stein, B.1    Brady, H.2    Yang, M.X.3    Young, D.B.4    Barbosa, M.S.5
  • 51
    • 0026457201 scopus 로고
    • Identification of MAPKAP kinase-2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins
    • Stokoe, D., Engel, K., Campbell, D.G., Cohen, P. and Gaestel, M. (1992a) Identification of MAPKAP kinase-2 as a major enzyme responsible for the phosphorylation of the small mammalian heat shock proteins. FEBS Lett., 313, 307-313.
    • (1992) FEBS Lett. , vol.313 , pp. 307-313
    • Stokoe, D.1    Engel, K.2    Campbell, D.G.3    Cohen, P.4    Gaestel, M.5
  • 52
    • 0026733636 scopus 로고
    • MAPKAP kinase-2; a novel protein kinase activated by mitogen-activated protein kinase
    • Stokoe, D., Campbell, D.G., Nakielny, S., Hidaka, H., Leevers, S.J., Marshall, C. and Cohen, P. (1992b) MAPKAP kinase-2; a novel protein kinase activated by mitogen-activated protein kinase. EMBO J., 11, 3985-3994
    • (1992) EMBO J. , vol.11 , pp. 3985-3994
    • Stokoe, D.1    Campbell, D.G.2    Nakielny, S.3    Hidaka, H.4    Leevers, S.J.5    Marshall, C.6    Cohen, P.7
  • 53
    • 0027739284 scopus 로고
    • The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2
    • Stokoe, D., Caudwell, B., Cohen, P.T.W. and Cohen, P. (1993) The substrate specificity and structure of mitogen-activated protein (MAP) kinase-activated protein kinase-2. Biochem. J., 296, 843-849.
    • (1993) Biochem. J. , vol.296 , pp. 843-849
    • Stokoe, D.1    Caudwell, B.2    Cohen, P.T.W.3    Cohen, P.4
  • 54
    • 0029790656 scopus 로고    scopus 로고
    • FGF and stress regulated CREB via a pathway involving the RK/p38 MAP kinase homologue and MAPKAP-2
    • Tan, Y., Rouse, J.R., Zhang, A., Cariati, S., Boccia, C., Cohen, P. and Comb, M.J. (1996) FGF and stress regulated CREB via a pathway involving the RK/p38 MAP kinase homologue and MAPKAP-2. EMBO J., 15, 4629-4642.
    • (1996) EMBO J. , vol.15 , pp. 4629-4642
    • Tan, Y.1    Rouse, J.R.2    Zhang, A.3    Cariati, S.4    Boccia, C.5    Cohen, P.6    Comb, M.J.7
  • 55
    • 0029938805 scopus 로고    scopus 로고
    • Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP kinase
    • Wang, X.Z. and Ron, D. (1996) Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP kinase. Science, 272, 1347-1348.
    • (1996) Science , vol.272 , pp. 1347-1348
    • Wang, X.Z.1    Ron, D.2
  • 56
    • 0029125757 scopus 로고
    • Integration of MAP kinase signal transduction pathways at the serum response element
    • Whitmarsh, A.J., Shore, P, Sarrocks, A.D. and Davis, R.J. (1995) Integration of MAP kinase signal transduction pathways at the serum response element. Science, 269, 403-407.
    • (1995) Science , vol.269 , pp. 403-407
    • Whitmarsh, A.J.1    Shore, P.2    Sarrocks, A.D.3    Davis, R.J.4
  • 57
    • 0029942952 scopus 로고    scopus 로고
    • Cloning of rat MEK kinase-1 cDNA reveals an endogenous membrane-associated 195 kDa protein with a large regulatory domain
    • Xu, S., Robbins, D.J., Christerson, L.B., English, J.M., Vanderbilt, C.A. and Cobb, M.H. (1996) Cloning of rat MEK kinase-1 cDNA reveals an endogenous membrane-associated 195 kDa protein with a large regulatory domain. Proc. Natl Acad. Sci. USA, 93, 5291-5295.
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 5291-5295
    • Xu, S.1    Robbins, D.J.2    Christerson, L.B.3    English, J.M.4    Vanderbilt, C.A.5    Cobb, M.H.6
  • 58
    • 0028670788 scopus 로고
    • Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1
    • Yan, M., Dai, T., Deak, J.C. Kyriakis, J.M., Zon, L.I., Woodgett, J.R. and Templeton, D.J. (1994) Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1. Nature, 372, 798-800.
    • (1994) Nature , vol.372 , pp. 798-800
    • Yan, M.1    Dai, T.2    Deak, J.C.3    Kyriakis, J.M.4    Zon, L.I.5    Woodgett, J.R.6    Templeton, D.J.7
  • 59
    • 0027184134 scopus 로고
    • Novel members of the mitogen-activated protein kinase activator family in Xenopus laevis
    • Yashar, B.M., Kelley, C., Yee, K., Errede, B. and Zon, L.I. (1993) Novel members of the mitogen-activated protein kinase activator family in Xenopus laevis. Mol. Cell. Biol., 13, 5738-5748.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 5738-5748
    • Yashar, B.M.1    Kelley, C.2    Yee, K.3    Errede, B.4    Zon, L.I.5
  • 60
    • 0028818395 scopus 로고
    • Mxi2, a mitogen-activated protein kinase that recognizes and phosphorylates Max protein
    • Zervos, A.S., Faccio, L., Gatto, J.P., Kyriakis, J.M. and Brent, R. (1995) Mxi2, a mitogen-activated protein kinase that recognizes and phosphorylates Max protein. Proc. Natl Acad. Sci. USA, 92, 10531-10534.
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 10531-10534
    • Zervos, A.S.1    Faccio, L.2    Gatto, J.P.3    Kyriakis, J.M.4    Brent, R.5
  • 61
    • 0029147738 scopus 로고
    • Protein synthesis inhibitors reveal differential regulation of mitogen-activated protein kinase and stress-activated protein kinase pathways that converge on Elk-1
    • Zinck, R., Cahill, M.A., Kracht, M., Sachsenmaier, C. Hipskind, R.A. and Nordheim, A. (1995) Protein synthesis inhibitors reveal differential regulation of mitogen-activated protein kinase and stress-activated protein kinase pathways that converge on Elk-1. Mol. Cell. Biol., 15, 4930-4938.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 4930-4938
    • Zinck, R.1    Cahill, M.A.2    Kracht, M.3    Sachsenmaier, C.4    Hipskind, R.A.5    Nordheim, A.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.