The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2

Molecular Cell

Volumn 9, Issue 5, 2002, Pages 945-956

  Lu, Zhimin ^a   Xu, Shuichan ^a   Joazeiro, Claudio ^a   Cobb, Melanie H ^b   Hunter, Tony ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYME; LIGASE; MEK KINASE; MITOGEN ACTIVATED PROTEIN KINASE; MUTANT PROTEIN; PROTEASOME; SORBITOL; THREONINE; TYROSINE; UBIQUITIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CHEMICAL REACTION; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME DEGRADATION; ENZYME STRUCTURE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; STRESS; UBIQUITINATION;

EID: 0036279167     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(02)00519-1     Document Type: Article

References (59)

1. Isolation and initial characterization of a novel zinc finger gene, DNMT3L, on 21q22.3, related to the cytosine-5-methyltransferase 3 gene family
2. The PHD finger: Implications for chromatin-mediated transcriptional regulation
3. The U box is a modified RING finger - A common domain in ubiquitination
4. The RING finger domain: A recent example of a sequence-structure family
5. Catalytic activation of the phosphatase MKP-3 by ERK2 mitogen-activated protein kinase
6. Activation mechanism of the MAP kinase ERK2 by dual phosphorylation
7. Solution structure of the PHD domain from the KAP-1 corepressor: Structural determinants for PHD, RING and LIM zinc-binding domains
8. Mammalian MAP kinase signalling cascades
9. MAP kinase pathways
10. A novel class of herpesvirus-encoded membrane-bound E3 ubiquitin ligases regulates endocytosis of proteins involved in immune recognition
11. Serine/threonine protein kinases and apoptosis
12. Signal transduction by the JNK group of MAP kinases
13. Regulation of the activity of MEK kinase 1 (MEKK1) by autophosphorylation within the kinase activation domain
14. Osmotic stress induces both secretion and apoptosis in rat alveolar type II cells
15. B-Raf inhibits programmed cell death downstream of cytochrome c release from mitochondria by activating the MEK/Erk pathway
16. The RING finger. A novel protein sequence motif related to the zinc finger
17. The epidermal growth factor receptor is covalently linked to ubiquitin
18. Mutations in transcriptional regulator ATRX establish the functional significance of a PHD-like domain
19. Genomic structure of the human ING1 gene and tumor-specific mutations detected in head and neck squamous cell carcinomas
20. Ubiquitin-dependent degradation of active Src
21. Ubiquitin-mediated degradation of active Src tyrosine kinase
22. U box proteins as a new family of ubiquitin-protein ligases
23. Signaling pathways mediating anti-apoptotic action of neurotrophins
24. Ubiquitin-dependent protein degradation
25. MAPK/ERK signaling in activated T cells inhibits CD95/Fas-mediated apoptosis downstream of DISC assembly
26. Membrane-bound human 3beta-hydroxysteroid dehydrogenase: Overexpression with His-tag using a baculovirus system and single-step purification
27. The lore of the RINGs: Substrate recognition and catalysis by ubiquitin ligases
28. Modifying chromatin and concepts of cancer
29. Biochemistry. Ubiquitination-more than two to tango
30. The tyrosine kinase negative regulator c-Cbl as a RING-type, E2- dependent ubiquitin-protein ligase
31. A proteolytic pathway that recognizes ubiquitin as a degradation signal
32. MEKK1 binds raf-1 and the ERK2 cascade components
33. Reconstitution of mitogen-activated protein kinase phosphorylation cascades in bacteria. Efficient synthesis of active protein kinases
34. A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly
35. Characterization of apoptosis induced by sorbitol: A unique system for the detection of antiapoptotic activities of viruses
36. A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf
37. The APC11 RING-H2 finger mediates E2-dependent ubiquitination
38. Biochemical analyses of the AF10 protein: The extended LAP/PHD-finger mediates oligomerisation
39. A novel human gene, WSTF, is deleted in Williams syndrome
40. Activation of protein kinase C triggers its ubiquitination and degradation
41. MEK inhibition enhances paclitaxel-induced tumor apoptosis
42. Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK
43. Ligand-induced ubiquitination of the platelet-derived growth factor beta-receptor plays a negative regulatory role in its mitogenic signaling
44. Structure of the PHD zinc finger from human Williams-Beuren syndrome transcription factor
45. AIRE encodes a nuclear protein co-localizing with cytoskeletal filaments: Altered sub-cellular distribution of mutants lacking the PHD zinc fingers
46. The leukemia-associated-protein (LAP) domain, a cysteine-rich motif, is present in a wide range of proteins, including MLL, AF10, and MLLT6 proteins
47. Identification of a novel mutation in the autoimmune regulator (AIRE-1) gene in a French family with autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy
48. Dissociation of cytokine-induced phosphorylation of Bad and activation of PKB/akt: Involvement of MEK upstream of Bad phosphorylation
49. Inhibition of extracellular signal-regulated kinase (ERK) mediates cell cycle phase independent apoptosis in vinblastine-treated ML-1 cells
50. A conserved docking motif in MAP kinases common to substrates, activators and regulators
51. MAPK/ERK overrides the apoptotic signaling from Fas, TNF, and TRAIL receptors
52. MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration
53. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis
54. MEKK1 phosphorylates MEK1 and MEK2 but does not cause activation of mitogen-activated protein kinase
55. Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane- associated 195-kDa protein with a large regulatory domain
56. The Ras/phosphatidylinositol 3-kinase and Ras/ERK pathways function as independent survival modules each of which inhibits a distinct apoptotic signaling pathway in sympathetic neurons
57. Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1
58. Mechanism of down-regulation of c-kit receptor. Roles of receptor tyrosine kinase, phosphatidylinositol 3′-kinase, and protein kinase C
59. Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption