JNK2 is required for efficient T-cell activation and apoptosis but not for normal lymphocyte development

Current Biology

Volumn 9, Issue 3, 1999, Pages 116-125

  Sabapathy, Kanaga ^a   Hu, Yinling ^b   Kallunki, Tuula ^b,c   Schreiber, Martin ^a   David, Jean Pierre ^a   Jochum, Wolfram ^a   Wagner, Erwin F ^a   Karin, Michael ^b  

^a RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c Danish Ctr Translational Breast Can   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 0033545386     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(99)80065-7     Document Type: Note

References (49)

1. Cobb M, Goldsmith EJ: How MAP kinases are regulated. J Biol Chem 1995, 270:14843-14846.
2. Karin M, Hunter T: Transcriptional control by protein phosphorylation: signal transmission from cell surface to the nucleus. Curr Biol 1995, 5:747-757.
3. Minden A, Karin M: Regulation and function of the JNK subgroup of MAP kinases. Biochem Biophys Acta 1997, 1333:F85-F104
4. Dérijard B, Hibi M, Wu IH, Barrett T, Su B, Deng T, et al.: JNK1: a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell 1994, 76:1025-1037.
5. Lee JC, Laydon JT, McDonnell PC, Gallagher TF, Kumar S, Green D, et al.: A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 1994, 372:739-746.
6. Hibi M, Lin A, Smeal T, Minden A, Karin M: Identification of an oncoprotein- and UV-responsive protein kinase that binds and potentiates the c-Jun activation domain. Genes Dev 1993, 7:2135-2148.
7. Kallunki T, Su B, Tsigelny I, Sluss HK, Dérijard B, Moore G, et al.: JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation. Genes Dev 1994, 8:2996-3007.
8. Minden A, Lin A, Claret FX, Abo A, Karin M: Selective activation of the JNK signaling cascade and c-Jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell 1995, 81:1147-1157.
9. Minden A, Lin A, McMahon M, Lange-Carter C, Dérijard B, Davis RJ, et al.: Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK. Science 1994, 266:1719-1723.
10. Dérijard B, Raingeaud J, Barrett T, Wu IH, Han J, Ulevitch RJ, et al.: Independent human MAP-kinase signal transduction pathways defined by MEKand MKK isoforms. Science 1995, 267:682-685.
11. Gupta S, Campbell D, Dérijard B, Davis RJ: Transcription factor ATF2: regulation by the JNK signal transduction pathway. Science 1995, 267:389-393.
12. Smeal T, Binétruy B, Mercola D, Birrer M, Karin M: Phosphorylation of c-Jun on serines 63 and 73 is required for oncogenic and transcriptional cooperation with Ha-Ras. Nature 1991, 354:494-496.
13. Lin A, Minden A, Martinetto H, Claret FX, Lange-Carter C, Mercurio F, et al.: Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2. Science 1995, 268286-290.
14. Sanchez I, Hughes RT, Mayer BJ, Yee K, Woodgett JR, Avruch J, et al.: Role of SAPK/ ERK kinase-1 in the stress-activated pathway regulating transcription factor c-Jun. Nature 1994, 372:794-798.
15. Wu Z, Jacinto E, Karin M: Molecular cloning and characterization of human JNKK2, a novel Jun N-terminal kinase (JNK)-specific kinase. Mol Cell Biol 1997, 17:7407-7416.
16. Mohit AA, Martin JH, Miller CA: p493F12 kinase: a novel MAP kinase expressed in a subset of neurons in the human nervous system. Neuron 1995, 14:67-78.
17. Gupta S, Barrett T, Whitmarsh AJ, Cavanagh J, Sluss HK, Dérijard B, et al.: Selective interaction of JNK protein kinase isoforms with transcription factors. EMBO J 1996, 15:2760-2770.
18. Blank JL, Gerwins P, Elliott EM, Sather S, Johnson GL: Molecular cloning of mitogen-activated protein/ ERK kinase kinases (MEKK) 2 and 3. J Biol Chem 1996, 274:5361-5368.
19. Gerwins P, Blank JL, Johnson GL: Cloning of a novel mitogen-activated protein kinase kinase kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway. J Biol Chem 1997, 272:8288-8295.
20. Ichijo H, Nishida E, Irie K, Dijke P, Saitoh M, Moriguchi T, et al.: Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/ JNK and p38 signaling pathways. Science 1997, 275:90-94.
21. Tibbles LA, Ing YL, Kiefer F, Chan J, Iscove N, Woodgett JR, et al.: MLK-3 activates the SAP/ JNK and p38/ RK pathways via SEK1 and MEK3/ 6. EMBO J 1996, 15:7026-7035.
22. Wang X, Diener K, Jannuzzi D, Trollinger D, Tan T, Lichenstein H, et al.: Molecular cloning and characterization of a novel protein kinase with a catalytic domain homologous to mitogen-activated protein kinase. J Biol Chem 1996, 271:31607-31611.
23. Yamaguchi K, Shirakabe K, Shibuya H, Irie K, Oishi I, Oeno N, et al.: Identification of a member of the MAPKKK family as a potential mediator of TGF-beta signal transduction. Science 1995, 270:2008-2011.
24. Crabtree GR: Contingent genetic regulatory events in T lymphocyte activation. Science 1989, 243:355-361.
25. Jacinto E, Werlen G, Karin M: Cooperation between Syk and Rac1 leads to synergistic JNK activation in T lymphocytes. Immunity 1998, 8:31-41.
26. Su B, Jacinto E, Hibi M, Kallunki T, Karin M, Ben-Neriah Y: JNK is involved in signal integration during costimulation of T lymphocytes. Cell 1994, 77:727-736.
27. Werlen G, Jacinto E, Xia Y, Karin M: Calcineurin preferentially synergizes with PKC-theta to activate JNK and IL-2 promoter in T lymphocytes. EMBO J 1998, 17:3101-3111.
28. Healy JI, Dolmetsch RE, Timmerman LA, Cyster JG, Thomas ML, Crabtree GR, et al.: Different nuclear signals are activated by the B cell receptor during positive versus negative signalling. Immunity 1997, 6:419-428.
29. 2-terminal kinase and mitogen-activated protein kinase signaling pathways. J Exp Med 1996, 183:2017-2023.
30. + T cells. Science 1996, 271:1272-1276.
31. Rincon M, Flavell RA: AP-1 transcriptional activity requires both T-cell receptor-mediated and co-stimulatory signals in primary T lymphocytes. EMBO J 1994, 13:4370-4381.
32. Kang SM, Bart B, Tran AC, Brorson D, Schwartz RH, Lenardo MJ: Transactivation by AP-1 is a molecular target of T cell clonal anergy. Science 1992, 257:1134-1138.
33. Kallunki T, Deng T, Hibi M, Karin M: c-Jun can recruit JNK to phosphorylate dimerization partners via specific docking interactions. Cell 1996, 87:929-939.
34. Lindstein T, June CH, Ledbetter JA, Stella G, Thompson CB: Regulation of lymphokine messenger RNA stability by a surface-mediated T cell activation pathway. Science 1989, 244:339-343.
35. 2-terminal kinase pathway through a 5′ response element. Science 1988, 280:1945-1949.
36. Chen J, Stewart V, Spyrou G, Hilberg F, Wagner EF, Alt FW: Generation of normal T and B lymphocytes by c-jun-deficient embryonic stem cells. Immunity 1994, 1:65-72.
37. Nishina H, Fischer KD, Ragvanyi L, Shahinian A, Hakem R, Ruble EA, et al.: Stress-signaling kinase Sek1 protects thymocytes from apoptosis mediated by CD95 and CD3. Nature 1997, 385:350-353.
38. Nishina H, Bachmann M, Oliveira-dos-Santos AJ, Kozieradzki I, Fischer KD, Odermatt B, et al.: Impaired CD28-mediated interleukin 2 production and proliferation in stress kinase SAPK/ ERK1 kinase (SEK1)/ mitogen-activated protein kinase kinase 4 (MKK4)-deficient T lymphocytes. J Exp Med 1997, 186:941-953.
39. Swat W, Fujikawa K, Ganiatis S, Yang D, Xavier RJ, Harris NL, et al.: SEK1/ MKK4 is required for maintenance of a normal peripheral lymphoid compartment but not for lymphocyte development. Immunity 1998, 8:625-634.
40. Yang D, Tournier C, Wysk M, Lu HT, Xu J, Davis RJ, et al.: Targeted disruption of the MKK4 gene causes embryonic death, inhibition of c-Jun NH2-terminal kinase activation, and defects in AP-1 transcriptional activity. Proc Natl Acad Sci USA 1997, 94:3004-3009.
41. Yang D, Kuan CY, Whitmarsh AJ, Rincon M, Zheng TS, Davis RJ, et al.: Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene. Nature 1997, 389:865-870.
42. Martin S, Bevan MJ: Antigen-specific and nonspecific deletion of cortical thymocytes caused by antigen injection. Eur J Immunol 1997, 27:2726-2736.
43. Berberich I, Shu G, Siebelt F, Woodgett JR, Kyriakis JM, Clark EA: Cross-linking CD40 of B cells preferentially induces stress-activated protein kinases rather than mitogen-activated protein kinases. EMBO J 1996, 15:92-101.
44. Katz P, Whalen G, Kherl JH: Differential expression of a novel protein kinase in human B lymphocytes. Preferential localisation in the germinal center. J Biol Chem 1994, 269:16802-16809.
45. Yang D, Conze D, Whitmarsh A, Barrett T, Davis RJ, Rincon M, Flavell RA: Differentiation of CD4+ T cells to TH1 cells required MAP Kinase JNK2. Immunity 1998, 9:575-585.
46. Paul WE, Seder RA: Lymphocyte response and cytokines. Cell 1994, 76241-251.
47. Schorle H, Holtschke T, Hunig T, Schimpl A, Horak I: Development and function of T cells in mice rendered interleukin-2 deficient by gene targeting. Nature 1991, 352:621-624.
48. Suzuki H, Kundig TM, Furlonger C, Wakeham A, Timms E, Matsuyama T, et al.: Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta. Science 1995, 268:1472-1476.
49. Willerford DM, Chen J, Ferry JA, Davidson L, Ma A, Alt F: Interleukin-2 receptor alpha chain regulates the size and content of the peripheral lymphoid compartment. Immunity 1995, 3:521-530.