A new Rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-κB signalling pathways

EMBO Journal

Volumn 17, Issue 5, 1998, Pages 1395-1404

  Tapon, Nicolas ^a   Nagata, Koh Ichi ^a   Lamarche, Nathalie ^a   Hall, Alan ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Apoptosis; JNK; NF B; POSH; Rac

Indexed keywords

ACTIN; GUANOSINE TRIPHOSPHATASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN CDC42; PROTEIN SERINE THREONINE KINASE; RAC PROTEIN; SYNAPTOTAGMIN; TRANSCRIPTION TERMINATION FACTOR RHO; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL STRAIN 3T3; CELL STRAIN COS1; CONTROLLED STUDY; CYTOSKELETON; ENZYME ACTIVITY; FIBROBLAST; GENE MUTATION; GENE OVEREXPRESSION; GENETIC TRANSCRIPTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN ISOLATION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

3T3 CELLS; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; BIOLOGICAL TRANSPORT; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CARRIER PROTEINS; CELL NUCLEUS; CLONING, MOLECULAR; COS CELLS; CYTOSKELETAL PROTEINS; ENZYME ACTIVATION; GTP-BINDING PROTEINS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE KINASES; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; MOLECULAR SEQUENCE DATA; NF-KAPPA B; PROTEIN-SERINE-THREONINE KINASES; RAC GTP-BINDING PROTEINS; SEQUENCE ANALYSIS, DNA; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS;

ANIMALIA;

EID: 0032473569     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/17.5.1395     Document Type: Article

References (3)

1. Abo, A., Pick, E., Hall, A., Totty,N., Teahan, C.G. and Segal, A.W. (1991) Activation of the NADPH oxidase involves the small GTP-binding protein p21rac 1. Nature, 353, 668-670.
2. Aspenstrom, P., Lindberg, U. and Hall, A. (1996) Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodefficiency disorder Wiskott-Aldrich syndrome. Curr. Biol., 6, 70-75.
3. Bagrodia,s., Derijard,B., Davis, R.J. and Cerione, R.A. (1995) Cdc42 and PAK-mediated signaling leads to Jun kinase and p38 mitogen-activated protein kinase activation. J. Biol. Chem. 270, 27996-27998.