Role of the JIP4 scaffold protein in the regulation of mitogen-activated protein kinase signaling pathways

Molecular and Cellular Biology

Volumn 25, Issue 7, 2005, Pages 2733-2743

  Kelkar, Nyaya ^a,b   Standen, Claire L ^a   Davis, Roger J ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b Enzon Incorporated   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

KINESIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 6; MOLECULAR MOTOR; SCAFFOLD PROTEIN; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INTERACTING PROTEIN 3; STRESS ACTIVATED PROTEIN KINASE INTERACTING PROTEIN 4; SYNAPTOPHYSIN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EMBRYO; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN INTERACTION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; CELLS, CULTURED; CERCOPITHECUS AETHIOPS; CLONING, MOLECULAR; CYTOPLASM; ENZYME ACTIVATION; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE 3; MAP KINASE KINASE 6; MAP KINASE KINASE 7; MAP KINASE KINASE KINASES; MAP KINASE SIGNALING SYSTEM; MICE; MICE, KNOCKOUT; MICROTUBULE-ASSOCIATED PROTEINS; NERVE TISSUE PROTEINS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PROTEIN BINDING;

EID: 15044357454     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.25.7.2733-2743.2005     Document Type: Article

References (37)

1. Bowman, A. B., A. Kamal, B. W. Ritchings, A. V. Philp, M. McGrail, J. G. Gindhart, and L. S. Goldstein. 2000. Kinesin-dependent axonal transport is mediated by the sunday driver (SYD) protein. Cell 103:583-594.
2. Brancho, D., N. Tanaka, A. Jaeschke, J. J. Ventura, N. Kelkar, Y. Tanaka, M. Kyuuma, T. Takeshita, R. A. Flavell and R. J. Davis. 2003. Mechanism of p38 MAP kinase activation in vivo. Genes Dev. 17:1969-1978.
3. Buchsbaum, R. J., B. A. Connolly, and L. A. Feig. 2002. Interaction of Rac exchange factors Tiam1 and Ras-GRF1 with a scaffold for the p38 mitogen-activated protein kinase cascade. Mol. Cell. Biol. 22:4073-4085.
4. Dickens, M., J. S. Rogers, J. Cavanagh, A. Raitano, Z. Xia, J. R. Halpern, M. E. Greenberg, C. L. Sawyers, and R. J. Davis. 1997. A cytoplasmic inhibitor of the JNK signal transduction pathway. Science 277:693-696.
5. Elion, E. A. 2001. The Ste5p scaffold. J. Cell Sci. 114:3967-3978.
6. Ge, B., H. Gram, F. Di Padova, B. Huang, L. New, R. J. Ulevitch, Y. Luo, and J. Han. 2002. MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha. Science 295:1291-1294.
7. Ge, B., X. Xiong, Q. Jing, J. L. Mosley, A. Filose, D. Bian, S. Huang, and J. Han. 2003. TAB1beta (transforming growth factor-beta-activated protein kinase 1-binding protein 1beta), a novel splicing variant of TAB1 that interacts with p38alpha but not TAK1. J. Biol. Chem. 278:2286-2293.
8. Harris, K., R. E. Lamson, B. Nelson, T. R. Hughes, M. J. Marton, C. J. Roberts, C. Boone, and P. M. Pryciak. 2001. Role of scaffolds in MAP kinase pathway specificity revealed by custom design of pathway-dedicated signaling proteins. Curr. Biol. 11:1815-1824.
9. Im, J. Y., K. W. Lee, M. H. Kim, S. H. Lee, H. Y. Ha, I. H. Cho, D. Kim, M. S. Yu, J. B. Kim, J. K. Lee, Y. J. Kim, B. W. Youn, S. D. Yang, H. S. Shin, and P. L. Han. 2003. Repression of phospho-JNK and infarct volume in ischemic brain of JIP1-deficient mice. J. Neurosci. Res. 74:326-332.
10. Ito, M., K. Yoshioka, M. Akechi, S. Yamashita, N. Takamatsu, K. Sugiyama, M. Hibi, Y. Nakabeppu, T. Shiba, and K. I. Yamamoto. 1999. JSAP1, a novel Jun N-terminal protein kinase (JNK)-binding protein that functions as a scaffold factor in the JNK signaling pathway. Mol. Cell. Biol. 19:7539-7548.
11. Jaeschke, A., M. P. Czech, and R. J. Davis. 2004. An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue. Genes Dev. 18:1976-1980.
12. Kelkar, N., M. H. Delmotte, C. R. Weston, T. Barrett, B. J. Sheppard, R. A. Flavell, and R. J. Davis. 2003. Morphogenesis of the telencephalic commissure requires scaffold protein JNK-interacting protein 3 (JIP3). Proc. Natl. Acad. Sci. USA 100:9843-9848.
13. Kelkar, N., S. Gupta, M. Dickens, and R. J. Davis. 2000. Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3. Mol. Cell. Biol. 20:1030-1043.
14. Kurzbauer, R., D. Teis, M. E. de Araujo, S. Maurer-Stroh, F. Eisenhaber, G. P. Bourenkov, H. D. Bartunik, M. Hekman, U. R. Rapp, L. A. Huber, and T. Clausen. 2004. Crystal structure of the p14/MP1 scaffolding complex: how a twin couple attaches mitogen-activated protein kinase signaling to late endosomes. Proc. Natl. Acad. Sci. USA 101:10984-10989.
15. Lee, C. M., D. Onesime, C. D. Reddy, N. Dhanasekaran, and E. P. Reddy. 2002. JLP: A scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors. Proc. Natl. Acad. Sci. USA 99:14189-14194.
16. Lu, H. T., D. D. Yang, M. Wysk, E. Gatti, I. Mellman, R. J. Davis, and R. A. Flavell. 1999. Defective IL-12 production in mitogen-activated protein (MAP) kinase kinase 3 (Mkk3)-deficient mice. EMBO J. 18:1845-1857.
17. Matsuguchi, T., A. Masuda, K. Sugimoto, Y. Nagai, and Y. Yoshikai. 2003. JNK-interacting protein 3 associates with Toll-like receptor 4 and is involved in LPS-mediated JNK activation. EMBO J. 22:4455-4464.
18. McDonald, P. H., C. W. Chow, W. E. Miller, S. A. Laporte, M. E. Field, F. T. Lin, R. J. Davis, and R. J. Lefkowitz. 2000. Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3. Science 290:1574-1577.
19. Morrison, D. K., and R. J. Davis. 2003. Regulation of MAP kinase signaling modules by scaffold proteins in mammals. Annu. Rev. Cell Dev. Biol. 19:91-118.
20. Nguyen, A., W. R. Burack, J. L. Stock, R. Kortum, O. V. Chaika, M. Afkarian, W. J. Muller, K. M. Murphy, D. K. Morrison, R. E. Lewis, J. McNeish, and A. S. Shaw. 2002. Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo. Mol. Cell. Biol. 22:3035-3045.
21. Park, S. H., A. Zarrinpar, and W. A. Lim. 2003. Rewiring MAP kinase pathways using alternative scaffold assembly mechanisms. Science 299:1061-1064.
22. Posas, F., and H. Saito. 1997. Osmotic activation of the HOG MAPK pathway via Ste11p MAPKKK: scaffold role of Pbs2p MAPKK. Science 276:1702-1705.
23. Schaeffer, H. J., A. D. Catling, S. T. Eblen, L. S. Collier, A. Krauss, and M. J. Weber. 1998. MP1: a MEK binding partner that enhances enzymatic activation of the MAP kinase cascade. Science 281:1668-1671.
24. Schoorlemmer, J., and M. Goldfarb. 2002. Fibroblast growth factor homologous factors and the islet brain-2 scaffold protein regulate activation of a stress-activated protein kinase. J. Biol. Chem. 277:49111-49119.
25. Schoorlemmer, J., and M. Goldfarb. 2001. Fibroblast growth factor homologous factors are intracellular signaling proteins. Curr. Biol. 11:793-797.
26. Shankar, S., B. Mohapatra, and A. Suri. 1998. Cloning of a novel human testis mRNA specifically expressed in testicular haploid germ cells, having unique palindromic sequences and encoding a leucine zipper dimerization motif. Biochem. Biophys. Res. Commun. 243:561-565.
27. Tanaka, N., M. Kamanaka, H. Enslen, C. Dong, M. Wysk, R. J. Davis, and R. A. Flavell. 2002. Differential involvement of p38 mitogen-activated protein kinase kinases MKK3 and MKK6 in T-cell apoptosis. EMBO Rep. 3:785-791.
28. Teis, D., W. Wunderlich, and L. A. Huber. 2002. Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction. Dev. Cell 3:803-814.
29. Thompson, N. A., J. A. Haefliger, A. Senn, T. Tawadros, F. Magara, B. Ledermann, P. Nicod, and G. Waeber. 2001. Islet-brain1/JNK-interacting protein-1 is required for early embryogenesis in mice. J. Biol. Chem. 276:27745-27748.
30. Uhlik, M. T., A. N. Abell, N. L. Johnson, W. Sun, B. D. Cuevas, K. E. Lobel-Rice, E. A. Horne, M. L. Dell'Acqua, and G. L. Johnson. 2003. Rac-MEKK3-MKK3 scaffolding for p38 MAPK activation during hyperosmotic shock. Nat. Cell Biol. 5:1104-1110.
31. Verhey, K. J., D. Meyer, R. Deehan, J. Blenis, B. J. Schnapp, T. A. Rapoport, and B. Margolis. 2001. Cargo of kinesin identified as JIP scaffolding proteins and associated signaling molecules. J. Cell Biol. 152:959-970.
32. Vomastek, T., H. J. Schaeffer, A. Tarcsafalvi, M. E. Smolkin, E. A. Bissonette, and M. J. Weber. 2004. Modular construction of a signaling scaffold: MORG1 interacts with components of the ERK cascade and links ERK signaling to specific agonists. Proc. Natl. Acad. Sci. USA 101:6981-6986.
33. Whitmarsh, A. J., J. Caranagh, C. Tournier, J. Yasuda, and R. J. Davis. 1998. A mammalian scaffold complex that selectively mediates MAP kinase activation. Science 281:1671-1674.
34. Whitmarsh, A. J., C. Y. Kuan, N. J. Kennedy, N. Kelkar, T. F. Haydar, J. P. Mordes, M. Appel, A. A. Rossini, S. N. Jones, R. A. Flavell, P. Rakic, and R. J. Davis. 2001. Requirement of the JIP1 scaffold protein for stress-induced JNK activation. Genes Dev. 15:2421-2432.
35. Wunderlich, W., I. Fialka, D. Teis, A. Alpi, A. Pfeifer, R. G. Parton, F. Lottspeich, and L. A. Huber. 2001. A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold mp1 on a late endosomal/lysosomal compartment. J. Cell Biol. 152:765-776.
36. Wysk, M., D. D. Yang, H. T. Lu, R. A. Flavell, and R. J. Davis. 1999. Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression. Proc. Natl. Acad. Sci. USA 96:3763-3768.
37. Yasuda, J., A. J. Whitmarsh, J. Cavanagh, M. Sharma, and R. J. Davis. 1999. The JIP group of mitogen-activated protein kinase scaffold proteins. Mol. Cell. Biol. 19:7245-7254.