The 3′ Untranslated region of tumor necrosis factor alpha mRNA is a target of the mRNA-stabilizing factor HuR

Molecular and Cellular Biology

Volumn 21, Issue 3, 2001, Pages 721-730

  Dean, J L E ^a   Wait, R ^a   Mahtani, K R ^a   Sully, G ^a   Clark, A R ^a   Saklatvala, J ^a  

^a IMPERIAL COLLEGE SCHOOL OF MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; PROLINE DERIVATIVE; TETRACYCLINE; TUMOR NECROSIS FACTOR ALPHA; DNA; ELAV-LIKE PROTEIN 1; GLOBIN; HUR PROTEIN; MEMBRANE ANTIGEN; PRIMER DNA; RNA BINDING PROTEIN;

3' UNTRANSLATED REGION; ANIMAL CELL; ARTICLE; ELECTROPHORETIC MOBILITY; GENE EXPRESSION; GENE LOCATION; GENE TARGETING; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN RNA BINDING; RNA METABOLISM; RNA STABILITY; RNA TRANSLATION; TANDEM MASS SPECTROMETRY; TRANSCRIPTION REGULATION; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; GENETICS; HELA CELL; ISOLATION AND PURIFICATION; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; REPORTER GENE; RNA PROCESSING;

3' UNTRANSLATED REGIONS; AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, SURFACE; BASE SEQUENCE; CELL LINE; DNA; DNA PRIMERS; GENE EXPRESSION; GENES, REPORTER; GLOBINS; HELA CELLS; HUMANS; MICE; MOLECULAR SEQUENCE DATA; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA STABILITY; RNA, MESSENGER; RNA-BINDING PROTEINS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034746363     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.3.721-730.2001     Document Type: Article

References (61)

1. Gapped BLAST and PSI-BLAST: A new generation of protein database search programs
2. Embryonic lethal abnormal visual RNA-binding proteins involved in growth, differentiation, and posttranscriptional gene expression
3. Messenger ribonucleoprotein complexes containing human ELAV proteins: Interactions with cytoskeleton and translational apparatus
4. ELAV protein HuA (HuR) can redistribute between nucleus and cytoplasm and is upregulated during serum stimulation and T cell activation
5. The biology of cachectin/TNF - A primary mediator of the host response
6. Regulation of tumour necrosis factor alpha mRNA stability by the mitogen-activated protein kinase p38 signalling cascade
7. Developmental regulation of RNA transcript destabilization by A + U-rich elements is AUF1-dependent
8. Identification of a common nucleotide sequence in the 3′-untranslated region of mRNA molecules specifying inflammatory mediators
9. Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin
10. AU-rich elements: Characterization and importance in mRNA degradation
11. Selective degradation of early-responsegene mRNAs: Functional analyses of sequence features of the AU-rich elements
12. p38 mitogen-activated protein kinase regulates cyclooxygenase-2 mRNA stability and transcription in lipopolysaccharide-treated human monocytes
13. HNS, a nuclear-cytoplasmic shuttling sequence in HuR
14. Overexpression of HuR, a nuclear-cytoplasmic shuttling protein, increases the in vivo stability of ARE-containing mRNAs
15. Role of cytokines in rheumatoid arthritis
16. ELAV proteins stabilize deadenylated intermediates in a novel in vitro mRNA deadenylation/degradation system
17. HuR binding to cytoplasmic mRNA is perturbed by heat shock
18. Mass spectrometric identification of proteins from silverstained polyacrylamide gel: A method for the removal of silver ions to enhance sensitivity
19. A conserved family of elav-like genes in vertebrates
20. Identification of TIAR as a protein binding to the translational regulatory AU-rich element of tumor necrosis factor alpha mRNA
21. Engagement of tumor necrosis factor mRNA by an endotoxin-inducible cytoplasmic protein
22. Association of heterogeneous nuclear ribonucleoprotein A1 and C proteins with reiterated AUUUA sequences
23. hnRNP A2 and hnRNP L bind the 3′UTR of glucose transporter 1 mRNA and exist as a complex in vivo
24. Endotoxin-responsive sequences control cachectin/tumor necrosis factor biosynthesis at the translational level
25. Two distinct regions in the 3′ untranslated region of tumor necrosis factor alpha mRNA form complexes with macrophage proteins
26. Mammalian Hsp70 and Hsp110 proteins bind to RNA motifs involved in mRNA stability
27. Ectopic expression of Hel-N1, an RNA-binding protein, increases glucose transporter (GLUT1) expression in 3T3-L1 adipocytes
28. Internal sequences from proteins digested in polyacrylamide gels
29. RNA-binding proteins TIA-1 and TIAR link the phosphorylation of elF-2 alpha to the assembly of mammalian stress granules
30. Mammalian homologs of Drosophila ELAV localized to a neuronal subset can bind in vitro to the 3′UTR of mRNA encoding the Id transcriptional repressor
31. Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: Implications for joint and gut-associated immunopathologies
32. Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA
33. Regulation of cyclooxygenase 2 mRNA stability by the mitogen-activated protein kinase p38 signaling cascade
34. He1-N1: An autoimmune RNA-binding protein with specificity for 3′ uridylate-rich untranslated regions of growth factor mRNAs
35. Hypoxic stabilization of vascular endothelial growth factor mRNA by the RNA-binding protein HuR
36. Poly(A) removal is the kinase-regulated step in tumor necrosis factor mRNA decay
37. Protein kinase regulates tumor necrosis factor mRNA stability in virus-stimulated astrocytes
38. Unraveling a cytoplasmic role for hnRNP D in the in vivo mRNA destabilization directed by the AU-rich element
39. Cloning and characterization of HuR, a ubiquitously expressed Elav-like protein
40. Regulation of interleukin-1beta-induced interleukin-6 gene expression in human fibroblast-like synoviocytes by p38 mitogen-activated protein kinase
41. Identification of HuR as a protein implicated in AUUUA-mediated mRNA decay
42. Isolation and characterization of a novel, low abundance hnRNP protein: A0
43. Glyceraldehyde-3-phosphate dehydrogenase selectively binds AU-rich RNA in the NAD(+)-binding region (Rossmann fold)
44. AUH, a gene encoding an AU-specific RNA binding protein with intrinsic enoyl-CoA hydratase activity
45. Control of tumor necrosis factor gene expression
46. RNA stabilization by the AU-rich element binding protein, HuR, an ELAV protein
47. Probability-based protein identification by searching sequence databases using mass spectrometry data
48. TIA-1 is a translational silencer that selectively regulates the expression of TNF-alpha
49. A p38 MAP kinase inhibitor regulates stability of interleukin-1-induced cyclooxygenase-2 mRNA
50. Binding of neuronal ELAV-like proteins to the uridine-rich sequence in the 3′-untranslated region of tumor necrosis factor-alpha messenger RNA
51. A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation
52. Mass spectrometric sequencing of proteins silver-stained polyacrylamide gels
53. HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and Sex-lethal
54. Improved mass accuracy in matrix-assisted laser desorption/ionization time-of flight mass spectrometry of peptides
55. Cytokine mRNA decay is accelerated by an inhibitor of p38-mitogen-activated protein kinase
56. HuR regulates cyclin A and cyclin B1 mRNA stability during cell proliferation
57. HuR regulates p21 mRNA stabilization by UV light
58. Femtomole sequencing of proteins from polyacrylamide gels by nano-electrospray mass spectrometry
59. The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism
60. A broader role for AU-rich element-mediated mRNA turnover revealed by a new transcriptional pulse strategy
61. Purification, characterization, and cDNA cloning of an AU-rich element RNA-binding protein