-
1
-
-
34547233770
-
Physiological roles of MKK4 and MKK7: Insights from animal models
-
Wang X, Destrument A, Tournier C. Physiological roles of MKK4 and MKK7: insights from animal models. Biochim Biophys Acta 2006; 1773:1349-57.
-
(2006)
Biochim Biophys Acta
, vol.1773
, pp. 1349-1357
-
-
Wang, X.1
Destrument, A.2
Tournier, C.3
-
2
-
-
36048978128
-
Mitogen-activated protein kinase kinase 4 is an essential activator of the c-Jun N-terminal protein kinase during brain development
-
Wang X, Nadarajah B, Robinson AC, et al. Mitogen-activated protein kinase kinase 4 is an essential activator of the c-Jun N-terminal protein kinase during brain development. Mol Cell Biol 2007;27:7935-46.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 7935-7946
-
-
Wang, X.1
Nadarajah, B.2
Robinson, A.C.3
-
3
-
-
0041660960
-
Mechanism of p38 MAP kinase activation in vivo
-
Branco D, Tanaka N, Jaeschke A, et al. Mechanism of p38 MAP kinase activation in vivo. Genes Dev 2003;17:1969-78.
-
(2003)
Genes Dev
, vol.17
, pp. 1969-1978
-
-
Branco, D.1
Tanaka, N.2
Jaeschke, A.3
-
4
-
-
0242361581
-
Transcriptional regulation by the MAP kinase signaling cascades
-
Yang S, Sharrocks AD, Whitmarsh AJ. Transcriptional regulation by the MAP kinase signaling cascades. Gene 2003;320:3-21.
-
(2003)
Gene
, vol.320
, pp. 3-21
-
-
Yang, S.1
Sharrocks, A.D.2
Whitmarsh, A.J.3
-
5
-
-
0035971506
-
Jun, the oncoprotein
-
Vogt PK. Jun, the oncoprotein. Oncogene 2001;20:2365-77.
-
(2001)
Oncogene
, vol.20
, pp. 2365-2377
-
-
Vogt, P.K.1
-
6
-
-
0034682264
-
Oncogenic transformation by ras and fos is mediated by c-Jun N-terminal phosphorylation
-
Behrens A, Jochum W, Sibilia M, Wagner EF. Oncogenic transformation by ras and fos is mediated by c-Jun N-terminal phosphorylation. Oncogene 2000;19:2657-63.
-
(2000)
Oncogene
, vol.19
, pp. 2657-2663
-
-
Behrens, A.1
Jochum, W.2
Sibilia, M.3
Wagner, E.F.4
-
7
-
-
0037337694
-
Suppression of Ras-stimulated transformation by the JNK signal transduction pathway
-
Kennedy NJ, Sluss HK, Jones SN, Bar-Sagi D, Flavell RA, Davis RJ. Suppression of Ras-stimulated transformation by the JNK signal transduction pathway. Genes Dev 2003;17:629-37.
-
(2003)
Genes Dev
, vol.17
, pp. 629-637
-
-
Kennedy, N.J.1
Sluss, H.K.2
Jones, S.N.3
Bar-Sagi, D.4
Flavell, R.A.5
Davis, R.J.6
-
8
-
-
0035872409
-
Suppression of skin tumorigenesis in c-Jun NH(2)-terminal kinase-2-deficient mice
-
Chen N, Nomura M, She QB, et al. Suppression of skin tumorigenesis in c-Jun NH(2)-terminal kinase-2-deficient mice. Cancer Res 2001;61:3908-12.
-
(2001)
Cancer Res
, vol.61
, pp. 3908-3912
-
-
Chen, N.1
Nomura, M.2
She, Q.B.3
-
9
-
-
0036494195
-
Deficiency of c-Jun-NH(2)-terminal kinase-1 in mice enhances skin tumor development by 12-O-tetradecanoylphorbol-13-acetate
-
She QB, Chen N, Bode AM, Flavell RA, Dong Z. Deficiency of c-Jun-NH(2)-terminal kinase-1 in mice enhances skin tumor development by 12-O-tetradecanoylphorbol-13-acetate. Cancer Res 2002;62: 1343-8.
-
(2002)
Cancer Res
, vol.62
, pp. 1343-1348
-
-
She, Q.B.1
Chen, N.2
Bode, A.M.3
Flavell, R.A.4
Dong, Z.5
-
10
-
-
0036730122
-
Survival signaling mediated by c-Jun NH(2)-terminal kinase in transformed B lymphoblasts
-
Hess P, Pihan G, Sawyers CL, Flavell RA, Davis RJ. Survival signaling mediated by c-Jun NH(2)-terminal kinase in transformed B lymphoblasts. Nat Genet 2002;32:201-5.
-
(2002)
Nat Genet
, vol.32
, pp. 201-205
-
-
Hess, P.1
Pihan, G.2
Sawyers, C.L.3
Flavell, R.A.4
Davis, R.J.5
-
11
-
-
0032100617
-
Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene
-
Su GH, Hilgers W, Shekher MC, et al. Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene. Cancer Res 1998;58:2339-42.
-
(1998)
Cancer Res
, vol.58
, pp. 2339-2342
-
-
Su, G.H.1
Hilgers, W.2
Shekher, M.C.3
-
12
-
-
4043110739
-
Evidence of MKK4 pro-oncogenic activity in breast and pancreatic tumors
-
Wang L, Pan Y, Dai JL. Evidence of MKK4 pro-oncogenic activity in breast and pancreatic tumors. Oncogene 2004;23:5978-85.
-
(2004)
Oncogene
, vol.23
, pp. 5978-5985
-
-
Wang, L.1
Pan, Y.2
Dai, J.L.3
-
13
-
-
33646814635
-
Targeted deletion of MKK4 in cancer cells: A detrimental phenotype manifests as decreased experimental metastasis and suggests a counterweight to the evolution of tumor-suppressor loss
-
Cunningham SC, Gallmeier E, Hucl T, et al. Targeted deletion of MKK4 in cancer cells: a detrimental phenotype manifests as decreased experimental metastasis and suggests a counterweight to the evolution of tumor-suppressor loss. Cancer Res 2006;66:5560-4.
-
(2006)
Cancer Res
, vol.66
, pp. 5560-5564
-
-
Cunningham, S.C.1
Gallmeier, E.2
Hucl, T.3
-
14
-
-
34248597048
-
Role of mitogen-activated protein kinase kinase 4 in cancer
-
Whitmarsh AJ, Davis RJ. Role of mitogen-activated protein kinase kinase 4 in cancer. Oncogene 2007;26:3172-84.l.
-
(2007)
Oncogene
, vol.26
-
-
Whitmarsh, A.J.1
Davis, R.J.2
-
15
-
-
0034002461
-
Integration of positive and negative growth signals during ras pathway activation in vivo
-
Frame S, Balmain A. Integration of positive and negative growth signals during ras pathway activation in vivo. Curr Opin Genet Dev 2000;10:106-13.
-
(2000)
Curr Opin Genet Dev
, vol.10
, pp. 106-113
-
-
Frame, S.1
Balmain, A.2
-
16
-
-
33750627972
-
A common signaling cascade may underlie "addiction" to the Src, BCR-ABL, and EGF receptor oncogenes
-
Sharma SV, Gajowniczek P, Way IP, et al. A common signaling cascade may underlie "addiction" to the Src, BCR-ABL, and EGF receptor oncogenes. Cancer Cell 2006;10:425-35.
-
(2006)
Cancer Cell
, vol.10
, pp. 425-435
-
-
Sharma, S.V.1
Gajowniczek, P.2
Way, I.P.3
-
17
-
-
0034583296
-
Targeted somatic mutagenesis in mouse epidermis
-
Indra AK, Li M, Brocard J, et al. Targeted somatic mutagenesis in mouse epidermis. Horm Res 2000;54:296-300.
-
(2000)
Horm Res
, vol.54
, pp. 296-300
-
-
Indra, A.K.1
Li, M.2
Brocard, J.3
-
18
-
-
0002084860
-
Morphological stages of postimplantation embryonic development
-
Copp AJ, Cockroft DL, editors. Oxford: IRL Press
-
Kaufman MH. Morphological stages of postimplantation embryonic development. In: Copp AJ, Cockroft DL, editors. Postimplantation mammalian embryos: A Practical Approach. Oxford: IRL Press; 1990, p. 81-91.
-
(1990)
Postimplantation Mammalian Embryos: A Practical Approach
, pp. 81-91
-
-
Kaufman, M.H.1
-
19
-
-
17644422790
-
Selective regulation of c-jun gene expression by the mitogen-activated protein kinases via the TPA-responsive element and the myocyte enhancer factor 2 binding sites
-
Kayahara M, Wang X, Tournier C. Selective regulation of c-jun gene expression by the mitogen-activated protein kinases via the TPA-responsive element and the myocyte enhancer factor 2 binding sites. Mol Cell Biol 2005;25:3784-92.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 3784-3792
-
-
Kayahara, M.1
Wang, X.2
Tournier, C.3
-
20
-
-
0031717379
-
Inducible gene targeting in mice using the Cre/lox system
-
Sauer B. Inducible gene targeting in mice using the Cre/lox system. Methods 1998;14:381-92.
-
(1998)
Methods
, vol.14
, pp. 381-392
-
-
Sauer, B.1
-
21
-
-
0028785807
-
Relating aromatic hydrocarbon-induced DNA adducts and c-H-ras mutations in mouse skin papillomas: The role of apurinic sites
-
Chakravarti D, Pelling JC, Cavalieri EL, Rogan EG. Relating aromatic hydrocarbon-induced DNA adducts and c-H-ras mutations in mouse skin papillomas: the role of apurinic sites. Proc Natl Acad Sci U S A 1995;92:10422-6.
-
(1995)
Proc Natl Acad Sci U S A
, vol.92
, pp. 10422-10426
-
-
Chakravarti, D.1
Pelling, J.C.2
Cavalieri, E.L.3
Rogan, E.G.4
-
22
-
-
0024276523
-
The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1
-
Angel P, Hattori K, Smeal T, Karin M. The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1. Cell 1988;55: 875-85.
-
(1988)
Cell
, vol.55
, pp. 875-885
-
-
Angel, P.1
Hattori, K.2
Smeal, T.3
Karin, M.4
-
23
-
-
0037604501
-
c-Jun regulates eyelid closure and skin tumor development through EGFR signaling
-
Zenz R, Scheuch H, Martin P, et al. c-Jun regulates eyelid closure and skin tumor development through EGFR signaling. Dev Cell 2003; 4:879-89.
-
(2003)
Dev Cell
, vol.4
, pp. 879-889
-
-
Zenz, R.1
Scheuch, H.2
Martin, P.3
-
24
-
-
0033104956
-
Control of cell cycle progression by c-Jun is p53 dependent
-
Schreiber M, Kolbus A, Piu F, et al. Control of cell cycle progression by c-Jun is p53 dependent. Genes Dev 1999;13:607-19.
-
(1999)
Genes Dev
, vol.13
, pp. 607-619
-
-
Schreiber, M.1
Kolbus, A.2
Piu, F.3
-
25
-
-
0032169459
-
JNK targets p53 ubiquitination and degradation in nonstressed cells
-
Fuchs SY, Adler V, Thomas B, et al. JNK targets p53 ubiquitination and degradation in nonstressed cells. Genes Dev 1998;12:2658-63.
-
(1998)
Genes Dev
, vol.12
, pp. 2658-2663
-
-
Fuchs, S.Y.1
Adler, V.2
Thomas, B.3
-
26
-
-
0030757691
-
Human mitogen-activated protein kinase 4 as a candidate tumor suppressor
-
Teng DH, Perry WL III, Hogan JK, et al. Human mitogen-activated protein kinase 4 as a candidate tumor suppressor. Cancer Res 1997;57:4177-82.
-
(1997)
Cancer Res
, vol.57
, pp. 4177-4182
-
-
Teng, D.H.1
Perry III, W.L.2
Hogan, J.K.3
-
27
-
-
0033229853
-
Mitogen-activated protein kinase kinase 4/stress-activated protein/ERK kinase 1 (MKK4/SEK1), a prostate cancer metastasis suppressor gene encoded by human chromosome 17
-
Yoshida BA, Dubauskas Z, Chekmareva MA, Christiano TR, Stadler WM, Rinker-Schaeffer CW. Mitogen-activated protein kinase kinase 4/stress-activated protein/ERK kinase 1 (MKK4/SEK1), a prostate cancer metastasis suppressor gene encoded by human chromosome 17. Cancer Res 1999;59:5483-7.
-
(1999)
Cancer Res
, vol.59
, pp. 5483-5487
-
-
Yoshida, B.A.1
Dubauskas, Z.2
Chekmareva, M.A.3
Christiano, T.R.4
Stadler, W.M.5
Rinker-Schaeffer, C.W.6
-
28
-
-
0035300477
-
Mitogen-activated protein kinase kinase 4 metastasis suppressor gene expression is inversely related to histological pattern in advancing human prostatic cancers
-
Kim HL, Vander Griend DJ, Yang X, et al. Mitogen-activated protein kinase kinase 4 metastasis suppressor gene expression is inversely related to histological pattern in advancing human prostatic cancers. Cancer Res 2001;61:2833-7.
-
(2001)
Cancer Res
, vol.61
, pp. 2833-2837
-
-
Kim, H.L.1
Vander Griend, D.J.2
Yang, X.3
-
29
-
-
0037112512
-
Mitogen-activated protein kinase kinase 4 (MKK4) acts as a metastasis suppressor gene in human ovarian carcinoma
-
Yamada SD, Hickson JA, Hrobowski Y, et al. Mitogen-activated protein kinase kinase 4 (MKK4) acts as a metastasis suppressor gene in human ovarian carcinoma. Cancer Res 2002;62:6717-23.
-
(2002)
Cancer Res
, vol.62
, pp. 6717-6723
-
-
Yamada, S.D.1
Hickson, J.A.2
Hrobowski, Y.3
-
30
-
-
19944429290
-
MAP2K4/MKK4 expression in pancreatic cancer: Genetic validation of immunohistochemistry and relationship to disease course
-
Xin W, Yun KJ, Ricci F, et al. MAP2K4/MKK4 expression in pancreatic cancer: genetic validation of immunohistochemistry and relationship to disease course. Clin Cancer Res 2004;10:8516-20.
-
(2004)
Clin Cancer Res
, vol.10
, pp. 8516-8520
-
-
Xin, W.1
Yun, K.J.2
Ricci, F.3
-
31
-
-
0033872092
-
Human gastric cancer kinase profile and prognostic significance of MKK4 kinase
-
Wu CW, Li AF, Chi CW, et al. Human gastric cancer kinase profile and prognostic significance of MKK4 kinase. Am J Pathol 2000; 156:2007-15.
-
(2000)
Am J Pathol
, vol.156
, pp. 2007-2015
-
-
Wu, C.W.1
Li, A.F.2
Chi, C.W.3
-
32
-
-
68249143415
-
Overexpression of mitogen-activated protein kinase kinase 4 and nuclear factor-κB in laryngeal squamous cell carcinoma: A potential indicator for poor prognosis
-
Huang C, Huang K, Wang C, et al. Overexpression of mitogen-activated protein kinase kinase 4 and nuclear factor-κB in laryngeal squamous cell carcinoma: a potential indicator for poor prognosis. Oncol Rep 2009;22:89-95.
-
(2009)
Oncol Rep
, vol.22
, pp. 89-95
-
-
Huang, C.1
Huang, K.2
Wang, C.3
-
33
-
-
0034607702
-
Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway
-
Tournier C, Hess P, Yang DD, et al. Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway. Science 2000;288:870-4.
-
(2000)
Science
, vol.288
, pp. 870-874
-
-
Tournier, C.1
Hess, P.2
Yang, D.D.3
-
34
-
-
0141723393
-
Role of JNK in tumor development
-
Kennedy NJ, Davis RJ. Role of JNK in tumor development. Cell Cycle 2003;2:199-201.
-
(2003)
Cell Cycle
, vol.2
, pp. 199-201
-
-
Kennedy, N.J.1
Davis, R.J.2
-
35
-
-
67650507032
-
JNK signalling modulates intestinal homeostasis and tumourigenesis in mice
-
Sancho R, Nateri AS, de Vinuesa AG, et al. JNK signalling modulates intestinal homeostasis and tumourigenesis in mice. EMBO J 2009; 28:1843-54.
-
(2009)
EMBO J
, vol.28
, pp. 1843-1854
-
-
Sancho, R.1
Nateri, A.S.2
De Vinuesa, A.G.3
-
36
-
-
0036494564
-
Differential gene expression profiles of Jnk1- And Jnk2-deficient murine fibroblast cells
-
Chen N, She QB, Bode AM, Dong Z. Differential gene expression profiles of Jnk1- and Jnk2-deficient murine fibroblast cells. Cancer Res 2002;62:1300-4.
-
(2002)
Cancer Res
, vol.62
, pp. 1300-1304
-
-
Chen, N.1
She, Q.B.2
Bode, A.M.3
Dong, Z.4
-
37
-
-
4444341881
-
Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation
-
Sabapathy K, Hochedlinger K, Nam SY, Bauer A, Karin M, Wagner EF. Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation. Mol Cell 2004;15:713-25.
-
(2004)
Mol Cell
, vol.15
, pp. 713-725
-
-
Sabapathy, K.1
Hochedlinger, K.2
Nam, S.Y.3
Bauer, A.4
Karin, M.5
Wagner, E.F.6
-
38
-
-
33748436341
-
JNK2 is a positive regulator of the cJun transcription factor
-
Jaeschke A, Karasarides M, Ventura JJ, et al. JNK2 is a positive regulator of the cJun transcription factor. Mol Cell 2006;23:899-911.
-
(2006)
Mol Cell
, vol.23
, pp. 899-911
-
-
Jaeschke, A.1
Karasarides, M.2
Ventura, J.J.3
-
39
-
-
33645862566
-
Jun signalling in the epidermis: From developmental defects to psoriasis and skin tumors
-
Zenz R, Wagner EF. Jun signalling in the epidermis: from developmental defects to psoriasis and skin tumors. Int J Biochem Cell Biol 2006;38:1043-9.
-
(2006)
Int J Biochem Cell Biol
, vol.38
, pp. 1043-1049
-
-
Zenz, R.1
Wagner, E.F.2
-
40
-
-
0027203921
-
Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors
-
Kemp CJ, Donehower LA, Bradley A, Balmain A. Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors. Cell 1993; 74:813-22.
-
(1993)
Cell
, vol.74
, pp. 813-822
-
-
Kemp, C.J.1
Donehower, L.A.2
Bradley, A.3
Balmain, A.4
|