-
1
-
-
0034698027
-
Raf-1-associated protein phosphatase 2Aas a positive regulator of kinase activation
-
Abraham D, Podar K, Pacher M, Kubicek M, Welzel N, Hemmings BA et al. (2000). Raf-1-associated protein phosphatase 2Aas a positive regulator of kinase activation. J Biol Chem 275: 22300-22304.
-
(2000)
J Biol Chem
, vol.275
, pp. 22300-22304
-
-
Abraham, D.1
Podar, K.2
Pacher, M.3
Kubicek, M.4
Welzel, N.5
Hemmings, B.A.6
-
2
-
-
0142059890
-
Molecular mechanism for a role of SHP2 in epidermal growth factor receptor signaling
-
Agazie YM, Hayman MJ. (2003). Molecular mechanism for a role of SHP2 in epidermal growth factor receptor signaling. Mol Cell Biol 23: 7875-7886.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 7875-7886
-
-
Agazie, Y.M.1
Hayman, M.J.2
-
3
-
-
0028293931
-
Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1
-
Alessi DR, Saito Y, Campbell DG, Cohen P, Sithanandam G, Rapp U et al. (1994). Identification of the sites in MAP kinase kinase-1 phosphorylated by p74raf-1. EMBO J 13: 1610-1619.
-
(1994)
EMBO J
, vol.13
, pp. 1610-1619
-
-
Alessi, D.R.1
Saito, Y.2
Campbell, D.G.3
Cohen, P.4
Sithanandam, G.5
Rapp, U.6
-
4
-
-
0028791436
-
Compartmentalized signal transduction by receptor tyrosine kinases
-
Baass PC, Di Guglielmo GM, Authier F, Posner BI, Bergeron JJ. (1995). Compartmentalized signal transduction by receptor tyrosine kinases. Trends Cell Biol 5: 465-470.
-
(1995)
Trends Cell Biol
, vol.5
, pp. 465-470
-
-
Baass, P.C.1
Di Guglielmo, G.M.2
Authier, F.3
Posner, B.I.4
Bergeron, J.J.5
-
5
-
-
0041488671
-
Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1
-
Bivona TG, Perez De Castro I, Ahearn IM, Grana TM, Chiu VK, Lockyer PJ et al. (2003). Phospholipase Cgamma activates Ras on the Golgi apparatus by means of RasGRP1. Nature 424: 694-698.
-
(2003)
Nature
, vol.424
, pp. 694-698
-
-
Bivona, T.G.1
Perez De Castro, I.2
Ahearn, I.M.3
Grana, T.M.4
Chiu, V.K.5
Lockyer, P.J.6
-
6
-
-
32444441115
-
PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis
-
Bivona TG, Quatela SE, Bodemann BO, Ahearn IM, Soskis MJ, Mor A et al. (2006). PKC regulates a farnesyl-electrostatic switch on K-Ras that promotes its association with Bcl-XL on mitochondria and induces apoptosis. Mol Cell 21: 481-493.
-
(2006)
Mol Cell
, vol.21
, pp. 481-493
-
-
Bivona, T.G.1
Quatela, S.E.2
Bodemann, B.O.3
Ahearn, I.M.4
Soskis, M.J.5
Mor, A.6
-
7
-
-
33846109356
-
Anovel human primary immunodeficiency syndrome caused by deficiency of the endosomal adaptor protein p14
-
Bohn G, Allroth A, Brandes G, Thiel J, Glocker E, Schaffer AA et al. (2007). Anovel human primary immunodeficiency syndrome caused by deficiency of the endosomal adaptor protein p14. Nat Med 13: 38-45.
-
(2007)
Nat Med
, vol.13
, pp. 38-45
-
-
Bohn, G.1
Allroth, A.2
Brandes, G.3
Thiel, J.4
Glocker, E.5
Schaffer, A.A.6
-
8
-
-
33751102674
-
Regulation of ras signaling dynamics by sos-mediated positive feedback
-
Boykevisch S, Zhao C, Sondermann H, Philippidou P, Halegoua S, Kuriyan J et al. (2006). Regulation of ras signaling dynamics by sos-mediated positive feedback. Curr Biol 16: 2173-2179.
-
(2006)
Curr Biol
, vol.16
, pp. 2173-2179
-
-
Boykevisch, S.1
Zhao, C.2
Sondermann, H.3
Philippidou, P.4
Halegoua, S.5
Kuriyan, J.6
-
9
-
-
0036905264
-
Move over protein kinase C, you've got company: Alternative cellular effectors of diacylglycerol and phorbol esters
-
Brose N, Rosenmund C. (2002). Move over protein kinase C, you've got company: alternative cellular effectors of diacylglycerol and phorbol esters. J Cell Sci 115: 4399-4411.
-
(2002)
J Cell Sci
, vol.115
, pp. 4399-4411
-
-
Brose, N.1
Rosenmund, C.2
-
10
-
-
0035162703
-
Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular trafficking
-
Burke P, Schooler K, Wiley HS. (2001). Regulation of epidermal growth factor receptor signaling by endocytosis and intracellular trafficking. Mol Biol Cell 12: 1897-1910.
-
(2001)
Mol Biol Cell
, vol.12
, pp. 1897-1910
-
-
Burke, P.1
Schooler, K.2
Wiley, H.S.3
-
11
-
-
0036091925
-
Ras signalling on the endoplasmic reticulum and the Golgi
-
Chiu VK, Bivona T, Hach A, Sajous JB, Silletti J, Wiener H et al. (2002). Ras signalling on the endoplasmic reticulum and the Golgi. Nat Cell Biol 4: 343-350.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 343-350
-
-
Chiu, V.K.1
Bivona, T.2
Hach, A.3
Sajous, J.B.4
Silletti, J.5
Wiener, H.6
-
12
-
-
0033538559
-
Endomembrane trafficking of ras: The CAAX motif targets proteins to the ER and Golgi
-
Choy E, Chiu VK, Silletti J, Feoktistov M, Morimoto T, Michaelson D et al. (1999). Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi. Cell 98: 69-80.
-
(1999)
Cell
, vol.98
, pp. 69-80
-
-
Choy, E.1
Chiu, V.K.2
Silletti, J.3
Feoktistov, M.4
Morimoto, T.5
Michaelson, D.6
-
13
-
-
33644854068
-
Erbin inhibits RAF activation by disrupting the sur-8-Ras-Raf complex
-
Dai P, Xiong WC, Mei L. (2006). Erbin inhibits RAF activation by disrupting the sur-8-Ras-Raf complex. J Biol Chem 281: 927-933.
-
(2006)
J Biol Chem
, vol.281
, pp. 927-933
-
-
Dai, P.1
Xiong, W.C.2
Mei, L.3
-
14
-
-
0031974151
-
Murine Ksr interacts with MEK and inhibits Ras-induced transformation
-
Denouel-Galy A, Douville EM, Warne PH, Papin C, Laugier D, Calothy G et al. (1998). Murine Ksr interacts with MEK and inhibits Ras-induced transformation. Curr Biol 8: 46-55.
-
(1998)
Curr Biol
, vol.8
, pp. 46-55
-
-
Denouel-Galy, A.1
Douville, E.M.2
Warne, P.H.3
Papin, C.4
Laugier, D.5
Calothy, G.6
-
15
-
-
0036684674
-
Untying the regulation of the Raf-1 kinase
-
Dhillon AS, Kolch W. (2002). Untying the regulation of the Raf-1 kinase. Arch Biochem Biophys 404: 3-9.
-
(2002)
Arch Biochem Biophys
, vol.404
, pp. 3-9
-
-
Dhillon, A.S.1
Kolch, W.2
-
16
-
-
0027965262
-
Compartmentalization of SHC, GRB2 and mSOS, and hyperphosphorylation of Raf-1 by EGF but not insulin in liver parenchyma
-
Di Guglielmo GM, Baass PC, Ou WJ, Posner BI, Bergeron JJ. (1994). Compartmentalization of SHC, GRB2 and mSOS, and hyperphosphorylation of Raf-1 by EGF but not insulin in liver parenchyma. EMBO J 13: 4269-4277.
-
(1994)
EMBO J
, vol.13
, pp. 4269-4277
-
-
Di Guglielmo, G.M.1
Baass, P.C.2
Ou, W.J.3
Posner, B.I.4
Bergeron, J.J.5
-
17
-
-
0029955128
-
Control of ras activation
-
Downward J. (1996). Control of ras activation. Cancer Surv 27: 87-100.
-
(1996)
Cancer Surv
, vol.27
, pp. 87-100
-
-
Downward, J.1
-
18
-
-
0032524389
-
RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs
-
Ebinu JO, Bottorff DA, Chan EY, Stang SL, Dunn RJ, Stone JC. (1998). RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs. Science 280: 1082-1086.
-
(1998)
Science
, vol.280
, pp. 1082-1086
-
-
Ebinu, J.O.1
Bottorff, D.A.2
Chan, E.Y.3
Stang, S.L.4
Dunn, R.J.5
Stone, J.C.6
-
20
-
-
33750962907
-
ARas-induced conformational switch in the Ras activator Son of sevenless
-
Freedman TS, Sondermann H, Friedland GD, Kortemme T, Bar-Sagi D, Marqusee S et al. (2006). ARas-induced conformational switch in the Ras activator Son of sevenless. Proc Natl Acad Sci USA 103: 16692-16697.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 16692-16697
-
-
Freedman, T.S.1
Sondermann, H.2
Friedland, G.D.3
Kortemme, T.4
Bar-Sagi, D.5
Marqusee, S.6
-
21
-
-
29144462587
-
Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization
-
Garnett MJ, Rana S, Paterson H, Barford D, Marais R. (2005). Wild-type and mutant B-RAF activate C-RAF through distinct mechanisms involving heterodimerization. Mol Cell 20: 963-969.
-
(2005)
Mol Cell
, vol.20
, pp. 963-969
-
-
Garnett, M.J.1
Rana, S.2
Paterson, H.3
Barford, D.4
Marais, R.5
-
22
-
-
22944460791
-
Depalmitoylated Ras traffics to and from the Golgi complex via a nonvesicular pathway
-
Goodwin JS, Drake KR, Rogers C, Wright L, Lippincott-Schwartz J, Philips MR et al. (2005). Depalmitoylated Ras traffics to and from the Golgi complex via a nonvesicular pathway. J Cell Biol 170: 261-272.
-
(2005)
J Cell Biol
, vol.170
, pp. 261-272
-
-
Goodwin, J.S.1
Drake, K.R.2
Rogers, C.3
Wright, L.4
Lippincott-Schwartz, J.5
Philips, M.R.6
-
23
-
-
2542433976
-
Shp2, an SH2-containing protein-tyrosine phosphatase, positively regulates receptor tyrosine kinase signaling by dephosphorylating and inactivating the inhibitor Sprouty
-
Hanafusa H, Torii S, Yasunaga T, Matsumoto K, Nishida E. (2004). Shp2, an SH2-containing protein-tyrosine phosphatase, positively regulates receptor tyrosine kinase signaling by dephosphorylating and inactivating the inhibitor Sprouty. J Biol Chem 279: 22992-22995.
-
(2004)
J Biol Chem
, vol.279
, pp. 22992-22995
-
-
Hanafusa, H.1
Torii, S.2
Yasunaga, T.3
Matsumoto, K.4
Nishida, E.5
-
24
-
-
0036847930
-
Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway
-
Hanafusa H, Torii S, Yasunaga T, Nishida E. (2002). Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway. Nat Cell Biol 4: 850-858.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 850-858
-
-
Hanafusa, H.1
Torii, S.2
Yasunaga, T.3
Nishida, E.4
-
25
-
-
0025013547
-
Apolybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane
-
Hancock JF, Paterson H, Marshall CJ. (1990). Apolybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane. Cell 63: 133-139.
-
(1990)
Cell
, vol.63
, pp. 133-139
-
-
Hancock, J.F.1
Paterson, H.2
Marshall, C.J.3
-
26
-
-
0037428508
-
Erbin suppresses the MAP kinase pathway
-
Huang YZ, Zang M, Xiong WC, Luo Z, Mei L. (2003). Erbin suppresses the MAP kinase pathway. J Biol Chem 278: 1108-1114.
-
(2003)
J Biol Chem
, vol.278
, pp. 1108-1114
-
-
Huang, Y.Z.1
Zang, M.2
Xiong, W.C.3
Luo, Z.4
Mei, L.5
-
27
-
-
6344255031
-
Paxillin serves as an ERK-regulated scaffold for coordinating FAK and Rac activation in epithelial morphogenesis
-
Ishibe S, Joly D, Liu ZX, Cantley LG. (2004). Paxillin serves as an ERK-regulated scaffold for coordinating FAK and Rac activation in epithelial morphogenesis. Mol Cell 16: 257-267.
-
(2004)
Mol Cell
, vol.16
, pp. 257-267
-
-
Ishibe, S.1
Joly, D.2
Liu, Z.X.3
Cantley, L.G.4
-
28
-
-
0344845048
-
Phosphorylation-dependent paxillin-ERK association mediates hepatocyte growth factor-stimulated epithelial morphogenesis
-
Ishibe S, Joly D, Zhu X, Cantley LG. (2003). Phosphorylation-dependent paxillin-ERK association mediates hepatocyte growth factor-stimulated epithelial morphogenesis. Mol Cell 12: 1275-1285.
-
(2003)
Mol Cell
, vol.12
, pp. 1275-1285
-
-
Ishibe, S.1
Joly, D.2
Zhu, X.3
Cantley, L.G.4
-
29
-
-
0033555229
-
Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase
-
Jacobs D, Glossip D, Xing H, Muslin AJ, Kornfeld K. (1999). Multiple docking sites on substrate proteins form a modular system that mediates recognition by ERK MAP kinase. Genes Dev 13: 163-175.
-
(1999)
Genes Dev
, vol.13
, pp. 163-175
-
-
Jacobs, D.1
Glossip, D.2
Xing, H.3
Muslin, A.J.4
Kornfeld, K.5
-
30
-
-
0842325725
-
Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways
-
Jaffe AB, Aspenstrom P, Hall A. (2004). Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction pathways. Mol Cell Biol 24: 1736-1746.
-
(2004)
Mol Cell Biol
, vol.24
, pp. 1736-1746
-
-
Jaffe, A.B.1
Aspenstrom, P.2
Hall, A.3
-
31
-
-
14744276941
-
Association of CNK1 with Rho guanine nucleotide exchange factors controls signaling specificity downstream of Rho
-
Jaffe AB, Hall A, Schmidt A. (2005). Association of CNK1 with Rho guanine nucleotide exchange factors controls signaling specificity downstream of Rho. Curr Biol 15: 405-412.
-
(2005)
Curr Biol
, vol.15
, pp. 405-412
-
-
Jaffe, A.B.1
Hall, A.2
Schmidt, A.3
-
32
-
-
0035811597
-
Protein phosphatases 1 and 2Apromote Raf-1 activation by regulating 14-3-3 interactions
-
Jaumot M, Hancock JF. (2001). Protein phosphatases 1 and 2Apromote Raf-1 activation by regulating 14-3-3 interactions. Oncogene 20: 3949-3958.
-
(2001)
Oncogene
, vol.20
, pp. 3949-3958
-
-
Jaumot, M.1
Hancock, J.F.2
-
33
-
-
0035999983
-
Coordinated traffic of Grb2 and Ras during epidermal growth factor receptor endocytosis visualized in living cells
-
Jiang X, Sorkin A. (2002). Coordinated traffic of Grb2 and Ras during epidermal growth factor receptor endocytosis visualized in living cells. Mol Biol Cell 13: 1522-1535.
-
(2002)
Mol Biol Cell
, vol.13
, pp. 1522-1535
-
-
Jiang, X.1
Sorkin, A.2
-
34
-
-
33344475413
-
Differential modification of Ras proteins by ubiquitination
-
Jura N, Scotto-Lavino E, Sobczyk A, Bar-Sagi D. (2006). Differential modification of Ras proteins by ubiquitination. Mol Cell 21: 679-687.
-
(2006)
Mol Cell
, vol.21
, pp. 679-687
-
-
Jura, N.1
Scotto-Lavino, E.2
Sobczyk, A.3
Bar-Sagi, D.4
-
35
-
-
0029085194
-
Identification of a putative Syp substrate, the PDGF beta receptor
-
Klinghoffer RA, Kazlauskas A. (1995). Identification of a putative Syp substrate, the PDGF beta receptor. J Biol Chem 270: 22208-22217.
-
(1995)
J Biol Chem
, vol.270
, pp. 22208-22217
-
-
Klinghoffer, R.A.1
Kazlauskas, A.2
-
36
-
-
27644575157
-
Coordinating ERK/MAPK signalling through scaffolds and inhibitors
-
Kolch W. (2005). Coordinating ERK/MAPK signalling through scaffolds and inhibitors. Nat Rev Mol Cell Biol 6: 827-837.
-
(2005)
Nat Rev Mol Cell Biol
, vol.6
, pp. 827-837
-
-
Kolch, W.1
-
37
-
-
0034655536
-
The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf
-
Li W, Han M, Guan K-L. (2000). The leucine-rich repeat protein SUR-8 enhances MAP kinase activation and forms a complex with Ras and Raf. Genes Dev 14: 895-900.
-
(2000)
Genes Dev
, vol.14
, pp. 895-900
-
-
Li, W.1
Han, M.2
Guan, K.-L.3
-
38
-
-
0027932676
-
Mitogen-activated protein (MAP) kinase phosphorylation of MAP kinase kinase: Determination of phosphorylation sites by mass spectrometry and site-directed mutagenesis
-
Mansour SJ, Resing KA, Candi JM, Hermann AS, Gloor JW, Herskind KR et al. (1994). Mitogen-activated protein (MAP) kinase phosphorylation of MAP kinase kinase: determination of phosphorylation sites by mass spectrometry and site-directed mutagenesis. J Biochem 116: 304-314.
-
(1994)
J Biochem
, vol.116
, pp. 304-314
-
-
Mansour, S.J.1
Resing, K.A.2
Candi, J.M.3
Hermann, A.S.4
Gloor, J.W.5
Herskind, K.R.6
-
39
-
-
0344885558
-
Structural evidence for feedback activation by Ras. GTP of the Ras-specific nucleotide exchange factor SOS
-
Margarit SM, Sondermann H, Hall BE, Nagar B, Hoelz A, Pirruccello M et al. (2003). Structural evidence for feedback activation by Ras. GTP of the Ras-specific nucleotide exchange factor SOS. Cell 112: 685-695.
-
(2003)
Cell
, vol.112
, pp. 685-695
-
-
Margarit, S.M.1
Sondermann, H.2
Hall, B.E.3
Nagar, B.4
Hoelz, A.5
Pirruccello, M.6
-
41
-
-
1642471746
-
Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP
-
Matheny SA, Chen C, Kortum RL, Razidlo GL, Lewis RE, White MA. (2004). Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP. Nature 427: 256-260.
-
(2004)
Nature
, vol.427
, pp. 256-260
-
-
Matheny, S.A.1
Chen, C.2
Kortum, R.L.3
Razidlo, G.L.4
Lewis, R.E.5
White, M.A.6
-
42
-
-
14044272770
-
Anovel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activation
-
Montagner A, Yart A, Dance M, Perret B, Salles JP, Raynal P. (2005). Anovel role for Gab1 and SHP2 in epidermal growth factor-induced Ras activation. J Biol Chem 280: 5350-5360.
-
(2005)
J Biol Chem
, vol.280
, pp. 5350-5360
-
-
Montagner, A.1
Yart, A.2
Dance, M.3
Perret, B.4
Salles, J.P.5
Raynal, P.6
-
43
-
-
33644864788
-
Compartmentalized Ras/MAPK signaling
-
Mor A, Philips MR. (2006). Compartmentalized Ras/MAPK signaling. Annu Rev Immunol 24: 771-800.
-
(2006)
Annu Rev Immunol
, vol.24
, pp. 771-800
-
-
Mor, A.1
Philips, M.R.2
-
44
-
-
0344393408
-
Regulation of MAP kinase signaling modules by scaffold proteins in mammals
-
Morrison DK, Davis RJ. (2003). Regulation of MAP kinase signaling modules by scaffold proteins in mammals. Annu Rev Cell Dev Biol 19: 91-118.
-
(2003)
Annu Rev Cell Dev Biol
, vol.19
, pp. 91-118
-
-
Morrison, D.K.1
Davis, R.J.2
-
45
-
-
0035930343
-
C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1
-
Muller J, Ory S, Copeland T, Piwnica-Worms H, Morrison DK. (2001). C-TAK1 regulates Ras signaling by phosphorylating the MAPK scaffold, KSR1. Mol Cell 8: 983-993.
-
(2001)
Mol Cell
, vol.8
, pp. 983-993
-
-
Muller, J.1
Ory, S.2
Copeland, T.3
Piwnica-Worms, H.4
Morrison, D.K.5
-
46
-
-
0038771965
-
The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling
-
Neel BG, Gu H, Pao L. (2003). The 'Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling. Trends Biochem Sci 28: 284-293.
-
(2003)
Trends Biochem Sci
, vol.28
, pp. 284-293
-
-
Neel, B.G.1
Gu, H.2
Pao, L.3
-
47
-
-
0042178312
-
Protein phosphatase 2Apositively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites
-
Ory S, Zhou M, Conrads TP, Veenstra TD, Morrison DK. (2003). Protein phosphatase 2Apositively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites. Curr Biol 13: 1356-1364.
-
(2003)
Curr Biol
, vol.13
, pp. 1356-1364
-
-
Ory, S.1
Zhou, M.2
Conrads, T.P.3
Veenstra, T.D.4
Morrison, D.K.5
-
48
-
-
0036769119
-
Regulation and targets of receptor tyrosine kinases
-
Pawson T. (2002). Regulation and targets of receptor tyrosine kinases. Eur J Cancer 38: S3-10.
-
(2002)
Eur J Cancer
, vol.38
-
-
Pawson, T.1
-
49
-
-
0025969093
-
Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase)
-
Payne DM, Rossomando AJ, Martino P, Erickson AK, Her JH, Shabanowitz J et al. (1991). Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase). EMBO J 10: 885-892.
-
(1991)
EMBO J
, vol.10
, pp. 885-892
-
-
Payne, D.M.1
Rossomando, A.J.2
Martino, P.3
Erickson, A.K.4
Her, J.H.5
Shabanowitz, J.6
-
50
-
-
29144528806
-
Ras signaling from plasma membrane and endomembrane microdomains
-
Plowman SJ, Hancock JF. (2005). Ras signaling from plasma membrane and endomembrane microdomains. Biochim Biophys Acta 1746: 274-283.
-
(2005)
Biochim Biophys Acta
, vol.1746
, pp. 274-283
-
-
Plowman, S.J.1
Hancock, J.F.2
-
51
-
-
0029294676
-
Guanine nucleotide exchange factors: Activators of the Ras superfamily of proteins
-
Quilliam LA, Khosravi-Far R, Huff SY, Der CJ. (1995). Guanine nucleotide exchange factors: activators of the Ras superfamily of proteins. BioEssays 17: 395-404.
-
(1995)
BioEssays
, vol.17
, pp. 395-404
-
-
Quilliam, L.A.1
Khosravi-Far, R.2
Huff, S.Y.3
Der, C.J.4
-
52
-
-
33846220591
-
CK2 is a component of the KSR1 scaffold complex that contributes to Raf kinase activation
-
Ritt DA, Zhou M, Conrads TP, Veenstra TD, Copeland TD, Morrison DK. (2007). CK2 is a component of the KSR1 scaffold complex that contributes to Raf kinase activation. Curr Biol 17: 179-184.
-
(2007)
Curr Biol
, vol.17
, pp. 179-184
-
-
Ritt, D.A.1
Zhou, M.2
Conrads, T.P.3
Veenstra, T.D.4
Copeland, T.D.5
Morrison, D.K.6
-
53
-
-
33845900943
-
Germline gain-of-function mutations in SOS1 cause Noonan syndrome
-
Roberts AE, Araki T, Swanson KD, Montgomery KT, Schiripo TA, Joshi VA et al. (2007). Germline gain-of-function mutations in SOS1 cause Noonan syndrome. Nat Genet 39: 70-74.
-
(2007)
Nat Genet
, vol.39
, pp. 70-74
-
-
Roberts, A.E.1
Araki, T.2
Swanson, K.D.3
Montgomery, K.T.4
Schiripo, T.A.5
Joshi, V.A.6
-
54
-
-
20144375061
-
An acylation cycle regulates localization and activity of palmitoylated Ras isoforms
-
Rocks O, Peyker A, Kahms M, Verveer PJ, Koerner C, Lumbierres M et al. (2005). An acylation cycle regulates localization and activity of palmitoylated Ras isoforms. Science 307: 1746-1752.
-
(2005)
Science
, vol.307
, pp. 1746-1752
-
-
Rocks, O.1
Peyker, A.2
Kahms, M.3
Verveer, P.J.4
Koerner, C.5
Lumbierres, M.6
-
55
-
-
33646034613
-
Aphosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity
-
Rodriguez-Viciana P, Oses-Prieto J, Burlingame A, Fried M, McCormick F. (2006). Aphosphatase holoenzyme comprised of Shoc2/Sur8 and the catalytic subunit of PP1 functions as an M-Ras effector to modulate Raf activity. Mol Cell 22: 217-230.
-
(2006)
Mol Cell
, vol.22
, pp. 217-230
-
-
Rodriguez-Viciana, P.1
Oses-Prieto, J.2
Burlingame, A.3
Fried, M.4
McCormick, F.5
-
57
-
-
0038613087
-
Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1
-
Sasaki A, Taketomi T, Kato R, Saeki K, Nonami A, Sasaki M et al. (2003). Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1. Nat Cell Biol 5: 427-432.
-
(2003)
Nat Cell Biol
, vol.5
, pp. 427-432
-
-
Sasaki, A.1
Taketomi, T.2
Kato, R.3
Saeki, K.4
Nonami, A.5
Sasaki, M.6
-
58
-
-
0034644539
-
Cell signaling by receptor tyrosine kinases
-
Schlessinger J. (2000). Cell signaling by receptor tyrosine kinases. Cell 103: 211-225.
-
(2000)
Cell
, vol.103
, pp. 211-225
-
-
Schlessinger, J.1
-
59
-
-
7044226349
-
Structural analysis of autoinhibition in the Ras activator Son of sevenless
-
Sondermann H, Soisson SM, Boykevisch S, Yang SS, Bar-Sagi D, Kuriyan J. (2004). Structural analysis of autoinhibition in the Ras activator Son of sevenless. Cell 119: 393-405.
-
(2004)
Cell
, vol.119
, pp. 393-405
-
-
Sondermann, H.1
Soisson, S.M.2
Boykevisch, S.3
Yang, S.S.4
Bar-Sagi, D.5
Kuriyan, J.6
-
60
-
-
0036341207
-
Signal transduction and endocytosis: Close encounters of many kinds
-
Sorkin A, Von Zastrow M. (2002). Signal transduction and endocytosis: close encounters of many kinds. Nat Rev Mol Cell Biol 3: 600-614.
-
(2002)
Nat Rev Mol Cell Biol
, vol.3
, pp. 600-614
-
-
Sorkin, A.1
Von Zastrow, M.2
-
61
-
-
33845884026
-
Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome
-
Tartaglia M, Pennacchio LA, Zhao C, Yadav KK, Fodale V, Sarkozy A et al. (2007). Gain-of-function SOS1 mutations cause a distinctive form of Noonan syndrome. Nat Genet 39: 75-79.
-
(2007)
Nat Genet
, vol.39
, pp. 75-79
-
-
Tartaglia, M.1
Pennacchio, L.A.2
Zhao, C.3
Yadav, K.K.4
Fodale, V.5
Sarkozy, A.6
-
62
-
-
33845709128
-
p14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasis
-
Teis D, Taub N, Kurzbauer R, Hilber D, de Araujo ME, Erlacher M et al. (2006). p14-MP1-MEK1 signaling regulates endosomal traffic and cellular proliferation during tissue homeostasis. J Cell Biol 175: 861-868.
-
(2006)
J Cell Biol
, vol.175
, pp. 861-868
-
-
Teis, D.1
Taub, N.2
Kurzbauer, R.3
Hilber, D.4
de Araujo, M.E.5
Erlacher, M.6
-
63
-
-
0036899420
-
Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction
-
Teis D, Wunderlich W, Huber LA. (2002). Localization of the MP1-MAPK scaffold complex to endosomes is mediated by p14 and required for signal transduction. Dev Cell 3: 803-814.
-
(2002)
Dev Cell
, vol.3
, pp. 803-814
-
-
Teis, D.1
Wunderlich, W.2
Huber, L.A.3
-
64
-
-
4344682999
-
Sef is a spatial regulator for Ras/MAP kinase signaling
-
Torii S, Kusakabe M, Yamamoto T, Maekawa M, Nishida E. (2004). Sef is a spatial regulator for Ras/MAP kinase signaling. Dev Cell 7: 33-44.
-
(2004)
Dev Cell
, vol.7
, pp. 33-44
-
-
Torii, S.1
Kusakabe, M.2
Yamamoto, T.3
Maekawa, M.4
Nishida, E.5
-
65
-
-
0035833471
-
SPRED is a Sprouty-related suppressor of Ras signalling
-
Wakioka T, Sasaki A, Kato R, Shouda T, Matsumoto A, Miyoshi K et al. (2001). SPRED is a Sprouty-related suppressor of Ras signalling. Nature 412: 647-651.
-
(2001)
Nature
, vol.412
, pp. 647-651
-
-
Wakioka, T.1
Sasaki, A.2
Kato, R.3
Shouda, T.4
Matsumoto, A.5
Miyoshi, K.6
-
66
-
-
12144289677
-
Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
-
Wan PT, Garnett MJ, Roe SM, Lee S, Niculescu-Duvaz D, Good VM et al. (2004). Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. Cell 116: 855-867.
-
(2004)
Cell
, vol.116
, pp. 855-867
-
-
Wan, P.T.1
Garnett, M.J.2
Roe, S.M.3
Lee, S.4
Niculescu-Duvaz, D.5
Good, V.M.6
-
69
-
-
0035911147
-
A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold mp1 on a late endosomal/lysosomal compartment
-
Wunderlich W, Fialka I, Teis D, Alpi A, Pfeifer A, Parton RG et al. (2001). A novel 14-kilodalton protein interacts with the mitogen-activated protein kinase scaffold mp1 on a late endosomal/lysosomal compartment. J Cell Biol 152: 765-776.
-
(2001)
J Cell Biol
, vol.152
, pp. 765-776
-
-
Wunderlich, W.1
Fialka, I.2
Teis, D.3
Alpi, A.4
Pfeifer, A.5
Parton, R.G.6
-
70
-
-
0034003003
-
Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the Raf kinase inhibitor protein
-
Yeung K, Janosch P, McFerran B, Rose DW, Mischak H, Sedivy JM et al. (2000). Mechanism of suppression of the Raf/MEK/extracellular signal-regulated kinase pathway by the Raf kinase inhibitor protein. Mol Cell Biol 20: 3079-3085.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 3079-3085
-
-
Yeung, K.1
Janosch, P.2
McFerran, B.3
Rose, D.W.4
Mischak, H.5
Sedivy, J.M.6
-
71
-
-
0031974812
-
Regulation of the MAP kinase pathway by mammalian Ksr through direct interaction with MEK and ERK
-
Yu W, Fantl WJ, Harrowe G, Williams LT. (1998). Regulation of the MAP kinase pathway by mammalian Ksr through direct interaction with MEK and ERK. Curr Biol 8: 56-64.
-
(1998)
Curr Biol
, vol.8
, pp. 56-64
-
-
Yu, W.1
Fantl, W.J.2
Harrowe, G.3
Williams, L.T.4
-
72
-
-
10744223870
-
Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment
-
Zhang SQ, Yang W, Kontaridis MI, Bivona TG, Wen G, Araki T et al. (2004). Shp2 regulates SRC family kinase activity and Ras/Erk activation by controlling Csk recruitment. Mol Cell 13: 341-355.
-
(2004)
Mol Cell
, vol.13
, pp. 341-355
-
-
Zhang, S.Q.1
Yang, W.2
Kontaridis, M.I.3
Bivona, T.G.4
Wen, G.5
Araki, T.6
-
73
-
-
0028329630
-
Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues
-
Zheng CF, Guan KL. (1994). Activation of MEK family kinases requires phosphorylation of two conserved Ser/Thr residues. EMBO J 13: 1123-1131.
-
(1994)
EMBO J
, vol.13
, pp. 1123-1131
-
-
Zheng, C.F.1
Guan, K.L.2
-
74
-
-
0036301210
-
Solution structure and functional analysis of the cysteine-rich C1 domain of kinase suppressor of Ras (KSR)
-
Zhou M, Horita DA, Waugh DS, Byrd RA, Morrison DK. (2002). Solution structure and functional analysis of the cysteine-rich C1 domain of kinase suppressor of Ras (KSR). J Mol Biol 315: 435-446.
-
(2002)
J Mol Biol
, vol.315
, pp. 435-446
-
-
Zhou, M.1
Horita, D.A.2
Waugh, D.S.3
Byrd, R.A.4
Morrison, D.K.5
-
75
-
-
21244463565
-
CNK1 is a scaffold protein that regulates Src-mediated Raf-1 activation
-
Ziogas A, Moelling K, Radziwill G. (2005). CNK1 is a scaffold protein that regulates Src-mediated Raf-1 activation. J Biol Chem 280: 24205-24211.
-
(2005)
J Biol Chem
, vol.280
, pp. 24205-24211
-
-
Ziogas, A.1
Moelling, K.2
Radziwill, G.3
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