Stabilization of interleukin-2 mRNA by the c-Jun NH2-terminal kinase pathway

Science

Volumn 280, Issue 5371, 1998, Pages 1945-1949

  Chen, Ching Yi ^a   Del Gatto Konczak, Fabienne ^a   Wu, Zhenguo ^a   Karin, Michael ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 2; MESSENGER RNA;

AMINO TERMINAL SEQUENCE; ARTICLE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; ONCOGENE C JUN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TRANSCRIPTION REGULATION;

ANTIGENS, CD28; ANTIGENS, CD3; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CALCIMYCIN; CYCLOSPORINE; ENZYME ACTIVATION; ENZYME INHIBITORS; GENE EXPRESSION REGULATION; HUMANS; IMIDAZOLES; INTERLEUKIN-2; JNK MITOGEN-ACTIVATED PROTEIN KINASES; JURKAT CELLS; LYMPHOCYTE ACTIVATION; MAP KINASE KINASE 1; MAP KINASE KINASE 7; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; PYRIDINES; RNA, MESSENGER; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TETRADECANOYLPHORBOL ACETATE; TRANSGENES;

EID: 0032546972     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.280.5371.1945     Document Type: Article

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48. We thank M. S. Barbosa for constitutively active MKK6, T. Kallunki for JNK2(GE), A. S. Kiselyov for synthesizing SB202190, and C. Moroni for helpful discussions. C.-Y.C., F.K., and Z.W. were supported by postdoctoral fellowships from the Leukemia Research Foundation and the Tobacco-Related Disease Research Program, Association pour la Recherche sur le Cancer, and Human Frontiers Science Project, respectively.