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Volumn 16, Issue 16, 1997, Pages 4973-4982

A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathways

Author keywords

MAP kinase; Phosphorylation; Protein kinase; Signal transduction; Stress response

Indexed keywords

ANISOMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; MUTANT PROTEIN; PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA;

EID: 0030851904     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/16.16.4973     Document Type: Article
Times cited : (159)

References (52)
  • 1
    • 0028302033 scopus 로고
    • GPD1, which encodes glycerol-3-phosphate dehydrogenase, is essential for growth under osmotic stress in Saccharomyces cerevisiae, and its expression is regulated by the high-osmolarity glycerol response pathway
    • Albertyn, J., Hohmann, S., Thevelein, J.M. and Prior, B.A. (1994) GPD1, which encodes glycerol-3-phosphate dehydrogenase, is essential for growth under osmotic stress in Saccharomyces cerevisiae, and its expression is regulated by the high-osmolarity glycerol response pathway. Mol. Cell. Biol., 14, 4135-4144.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 4135-4144
    • Albertyn, J.1    Hohmann, S.2    Thevelein, J.M.3    Prior, B.A.4
  • 2
    • 0029913457 scopus 로고    scopus 로고
    • Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3
    • Blank, J.L., Gerwins, P., Elliot, E.M., Sather, S. and Johnson, G.L. (1996) Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3. J. Biol. Chem., 271, 5361-5368.
    • (1996) J. Biol. Chem. , vol.271 , pp. 5361-5368
    • Blank, J.L.1    Gerwins, P.2    Elliot, E.M.3    Sather, S.4    Johnson, G.L.5
  • 3
    • 0026443099 scopus 로고
    • PBS2, a yeast gene encoding a putative protein kinase, interacts with the RAS2 pathway and affects osmotic sensitivity of Saccharomyces cerevisiae
    • Boguslawski, G. (1992) PBS2, a yeast gene encoding a putative protein kinase, interacts with the RAS2 pathway and affects osmotic sensitivity of Saccharomyces cerevisiae. J. Gen. Microbiol., 138, 2425-2432.
    • (1992) J. Gen. Microbiol. , vol.138 , pp. 2425-2432
    • Boguslawski, G.1
  • 4
    • 0023387939 scopus 로고
    • Complete nucleotide sequence of a gene conferring polymyxin B resistance on yeast: Similarity of the predicted polypeptide to protein kinases
    • Boguslawski, G. and Polazzi, J.O. (1987) Complete nucleotide sequence of a gene conferring polymyxin B resistance on yeast: similarity of the predicted polypeptide to protein kinases. Proc. Natl Acad. Sci. USA, 84, 5848-5852.
    • (1987) Proc. Natl Acad. Sci. USA , vol.84 , pp. 5848-5852
    • Boguslawski, G.1    Polazzi, J.O.2
  • 5
    • 0017184389 scopus 로고
    • A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
    • Bradford, M.M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72, 248-254.
    • (1976) Anal. Biochem. , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 8
    • 0029043582 scopus 로고    scopus 로고
    • How MAP kinases are regulated
    • Cobb, M.H. and Goldsmith, E.J. (1996) How MAP kinases are regulated. J. Biol. Chem., 270, 14843-14846.
    • (1996) J. Biol. Chem. , vol.270 , pp. 14843-14846
    • Cobb, M.H.1    Goldsmith, E.J.2
  • 9
    • 0028675593 scopus 로고
    • MAP kinase pathways: Straight and narrow or tortuous and intersecting?
    • Cooper, J.A. (1994) MAP kinase pathways: Straight and narrow or tortuous and intersecting? Curr. Biol., 4, 1118-1121.
    • (1994) Curr. Biol. , vol.4 , pp. 1118-1121
    • Cooper, J.A.1
  • 10
    • 0029055812 scopus 로고
    • The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway
    • Coso, O.A., Chiariello, M., Yu, J.-C. Teramoto, H., Crespo, P., Xu, N., Miki, T. and Gutkind, J.S. (1995) The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell, 81, 1137-1146.
    • (1995) Cell , vol.81 , pp. 1137-1146
    • Coso, O.A.1    Chiariello, M.2    Yu, J.-C.3    Teramoto, H.4    Crespo, P.5    Xu, N.6    Miki, T.7    Gutkind, J.S.8
  • 11
    • 0031024646 scopus 로고    scopus 로고
    • Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38)
    • Cuenda, A., Cohen, P., Buée-Scherrer, V. and Goedert, M. (1997) Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38). EMBO J., 16, 295-305.
    • (1997) EMBO J. , vol.16 , pp. 295-305
    • Cuenda, A.1    Cohen, P.2    Buée-Scherrer, V.3    Goedert, M.4
  • 12
    • 0028073283 scopus 로고
    • MAPKs: New JNK expands the group
    • Davis, R.J. (1994) MAPKs: new JNK expands the group. Trends Biochem. Sci., 19, 470-473.
    • (1994) Trends Biochem. Sci. , vol.19 , pp. 470-473
    • Davis, R.J.1
  • 13
    • 0028329953 scopus 로고
    • JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
    • Dérijard, B., Hibi, M., Wu, I.H., Barrett, T., Su, B., Deng, T., Karin, M. and Davis, R.J. (1994) JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain. Cell, 76, 1025-1037.
    • (1994) Cell , vol.76 , pp. 1025-1037
    • Dérijard, B.1    Hibi, M.2    Wu, I.H.3    Barrett, T.4    Su, B.5    Deng, T.6    Karin, M.7    Davis, R.J.8
  • 14
    • 0028935974 scopus 로고
    • Independent human MAP kinase signal transduction pathways defined by MEK and MKK isoforms
    • Dérijard, B., Raingeaud, J., Barren, T., Wu, I.-H., Han, J., Ulevitch, R.J. and Davis, R.J. (1995) Independent human MAP kinase signal transduction pathways defined by MEK and MKK isoforms. Science, 267, 682-685.
    • (1995) Science , vol.267 , pp. 682-685
    • Dérijard, B.1    Raingeaud, J.2    Barren, T.3    Wu, I.-H.4    Han, J.5    Ulevitch, R.J.6    Davis, R.J.7
  • 15
    • 0028015872 scopus 로고
    • Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27
    • Freshney, N.W., Rawlinson, L., Guesdon, F., Jones, E., Cowley, S., Hsuan, J. and Saklatvala, J. (1994) Interleukin-1 activates a novel protein kinase cascade that results in the phosphorylation of Hsp27. Cell, 78, 1039-1049.
    • (1994) Cell , vol.78 , pp. 1039-1049
    • Freshney, N.W.1    Rawlinson, L.2    Guesdon, F.3    Jones, E.4    Cowley, S.5    Hsuan, J.6    Saklatvala, J.7
  • 16
    • 0030934694 scopus 로고    scopus 로고
    • Cloning of a novel mitogen-activated protein kinase kinase kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway
    • Gerwins, P., Blank, J.L. and Johnson, G.L. (1997) Cloning of a novel mitogen-activated protein kinase kinase kinase, MEKK4, that selectively regulates the c-Jun amino terminal kinase pathway. J. Biol. Chem., 272, 8288-8295.
    • (1997) J. Biol. Chem. , vol.272 , pp. 8288-8295
    • Gerwins, P.1    Blank, J.L.2    Johnson, G.L.3
  • 17
    • 0027936755 scopus 로고
    • A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells
    • Han, J., Lee, J.-D., Bibbs, L. and Ulevitch, R.J. (1994) A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science, 265, 808-811.
    • (1994) Science , vol.265 , pp. 808-811
    • Han, J.1    Lee, J.-D.2    Bibbs, L.3    Ulevitch, R.J.4
  • 18
    • 0026345394 scopus 로고
    • Protein kinase catalytic domain sequence database: Identification of conserved features of primary structure and classification of family members
    • Hanks, S.K. and Quinn, A.M. (1991) Protein kinase catalytic domain sequence database: identification of conserved features of primary structure and classification of family members. Methods Enzymol., 200, 38-62.
    • (1991) Methods Enzymol. , vol.200 , pp. 38-62
    • Hanks, S.K.1    Quinn, A.M.2
  • 19
    • 0028985079 scopus 로고
    • MAP kinase pathways in yeast: For mating and more
    • Herskowitz, I. (1995) MAP kinase pathways in yeast: for mating and more. Cell, 80, 187-197.
    • (1995) Cell , vol.80 , pp. 187-197
    • Herskowitz, I.1
  • 20
    • 0030024707 scopus 로고    scopus 로고
    • Activation of the JNK pathway by distantly related protein kinases, MEKK and MUK
    • Hirai, S., Izawa, M., Osada, S., Spyrou, G. and Ohno, S. (1996) Activation of the JNK pathway by distantly related protein kinases, MEKK and MUK. Oncogene, 12, 641-650.
    • (1996) Oncogene , vol.12 , pp. 641-650
    • Hirai, S.1    Izawa, M.2    Osada, S.3    Spyrou, G.4    Ohno, S.5
  • 21
    • 14444281569 scopus 로고    scopus 로고
    • Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways
    • Ichijo, H. et al. (1997) Induction of apoptosis by ASK1, a mammalian MAPKKK that activates SAPK/JNK and p38 signaling pathways. Science, 275, 90-94.
    • (1997) Science , vol.275 , pp. 90-94
    • Ichijo, H.1
  • 22
    • 0029744885 scopus 로고    scopus 로고
    • Sounding the alarm: Protein kinase cascades activated by stress and inflammation
    • Kyriakis, J.M. and Avruch, J. (1996) Sounding the alarm: protein kinase cascades activated by stress and inflammation. J. Biol. Chem., 271, 24313-24316.
    • (1996) J. Biol. Chem. , vol.271 , pp. 24313-24316
    • Kyriakis, J.M.1    Avruch, J.2
  • 24
    • 0027215820 scopus 로고
    • A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf
    • Lange-Carter, C.A., Pleiman, C.M., Gardner, A.M., Blumer, K.J. and Johnson, G.L. (1993) A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf. Science, 260, 315-319.
    • (1993) Science , vol.260 , pp. 315-319
    • Lange-Carter, C.A.1    Pleiman, C.M.2    Gardner, A.M.3    Blumer, K.J.4    Johnson, G.L.5
  • 25
    • 0028605318 scopus 로고
    • A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
    • Lee, J.C. et al. (1994) A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature, 372, 739-746.
    • (1994) Nature , vol.372 , pp. 739-746
    • Lee, J.C.1
  • 27
    • 0028228109 scopus 로고
    • A two-component system that regulates an osmosensing MAP kinase cascade in yeast
    • Maeda, T., Wurgler-Murphy, S.M. and Saito, H. (1994) A two-component system that regulates an osmosensing MAP kinase cascade in yeast. Nature, 369, 242-245.
    • (1994) Nature , vol.369 , pp. 242-245
    • Maeda, T.1    Wurgler-Murphy, S.M.2    Saito, H.3
  • 28
    • 0029028962 scopus 로고
    • Activation of yeast PBS2 MAPKK by MAPKKKs or by binding of an SH3-containing osmosensor
    • Maeda, T., Takekawa, M. and Saito, H. (1995) Activation of yeast PBS2 MAPKK by MAPKKKs or by binding of an SH3-containing osmosensor. Science, 269, 554-558.
    • (1995) Science , vol.269 , pp. 554-558
    • Maeda, T.1    Takekawa, M.2    Saito, H.3
  • 29
    • 0028152333 scopus 로고
    • MAP kinase kinase kinase, MAP kinase kinase and MAP kinase
    • Marshall, C.J. (1994) MAP kinase kinase kinase, MAP kinase kinase and MAP kinase. Curr. Opin. Genet. Dev., 4, 82-89.
    • (1994) Curr. Opin. Genet. Dev. , vol.4 , pp. 82-89
    • Marshall, C.J.1
  • 30
    • 0029913458 scopus 로고    scopus 로고
    • SAP kinase-3, a new member of the family of mammalian stress-activated protein kinases
    • Mertens, S., Craxton, M. and Goedert, M. (1996) SAP kinase-3, a new member of the family of mammalian stress-activated protein kinases. FEBS Lett., 383, 796-805.
    • (1996) FEBS Lett. , vol.383 , pp. 796-805
    • Mertens, S.1    Craxton, M.2    Goedert, M.3
  • 31
    • 0029070887 scopus 로고
    • Selective activation of the JNK signaling cascade and c-jun transcriptional activity by the small GTPases Rac and Cdc42Hs
    • Minden, A., Lin, A., Claret, F.-X., Abo, A. and Karin, M. (1995) Selective activation of the JNK signaling cascade and c-jun transcriptional activity by the small GTPases Rac and Cdc42Hs. Cell, 81, 1147-1157.
    • (1995) Cell , vol.81 , pp. 1147-1157
    • Minden, A.1    Lin, A.2    Claret, F.-X.3    Abo, A.4    Karin, M.5
  • 32
    • 0025946804 scopus 로고
    • Cloning of a human cDNA encoding a CDC2-related kinase by complementation of a budding yeast cdc28 mutation
    • Ninomiya-Tsuji, J., Nomoto, S., Yasuda, H., Reed, S.I. and Matsumoto, K. (1991) Cloning of a human cDNA encoding a CDC2-related kinase by complementation of a budding yeast cdc28 mutation. Proc. Natl Acad. Sci. USA, 88, 9006-9010.
    • (1991) Proc. Natl Acad. Sci. USA , vol.88 , pp. 9006-9010
    • Ninomiya-Tsuji, J.1    Nomoto, S.2    Yasuda, H.3    Reed, S.I.4    Matsumoto, K.5
  • 33
    • 0027507956 scopus 로고
    • A yeast protein similar to bacterial two-component regulators
    • Ota, I.M. and Varshavsky, A. (1993) A yeast protein similar to bacterial two-component regulators. Science, 262, 566-569.
    • (1993) Science , vol.262 , pp. 566-569
    • Ota, I.M.1    Varshavsky, A.2
  • 34
    • 0029796368 scopus 로고    scopus 로고
    • Activation of p38 mitogen-activated protein kinase by c-abl-dependent and -independent mechanisms
    • Pandey, P., Raingeaud, J., Kaneki, M., Weichselbaum, R., Davis, R.J., Kufe, D. and Kharbanda, S. (1996) Activation of p38 mitogen-activated protein kinase by c-abl-dependent and -independent mechanisms. J. Biol. Chem., 271, 23775-23779.
    • (1996) J. Biol. Chem. , vol.271 , pp. 23775-23779
    • Pandey, P.1    Raingeaud, J.2    Kaneki, M.3    Weichselbaum, R.4    Davis, R.J.5    Kufe, D.6    Kharbanda, S.7
  • 35
    • 0030815562 scopus 로고    scopus 로고
    • Osmotic activation of the HOG MAPK pathway via Stellp MAPKKK: Scaffold role of Pbs2p MAPKK
    • Posas, F. and Saito, H. (1997) Osmotic activation of the HOG MAPK pathway via Stellp MAPKKK: Scaffold role of Pbs2p MAPKK. Science, 276, 1702-1705.
    • (1997) Science , vol.276 , pp. 1702-1705
    • Posas, F.1    Saito, H.2
  • 36
    • 0030595378 scopus 로고    scopus 로고
    • Yeast HOG1 MAP kinase cascade is regulated by a multistep phosphorelay mechanism in the SLN1-YPD1-SSK1 'two-component' osmosensor
    • Posas, F., Wurgler-Murphy, S.M., Maeda, T., Witten, E.A., Thai, T.C. and Saito, H. (1996) Yeast HOG1 MAP kinase cascade is regulated by a multistep phosphorelay mechanism in the SLN1-YPD1-SSK1 'two-component' osmosensor. Cell, 86, 865-875.
    • (1996) Cell , vol.86 , pp. 865-875
    • Posas, F.1    Wurgler-Murphy, S.M.2    Maeda, T.3    Witten, E.A.4    Thai, T.C.5    Saito, H.6
  • 37
    • 0030051528 scopus 로고    scopus 로고
    • MKK3- And MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway
    • Raingeaud, J., Whitmarsh, A.J., Barrett, T., Dérijard, B. and Davis, R.J. (1996) MKK3-and MKK6-regulated gene expression is mediated by the p38 mitogen-activated protein kinase signal transduction pathway. Mol. Cell. Biol., 16, 1247-1255.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 1247-1255
    • Raingeaud, J.1    Whitmarsh, A.J.2    Barrett, T.3    Dérijard, B.4    Davis, R.J.5
  • 38
    • 0029760613 scopus 로고    scopus 로고
    • The mixed lineage kinase SPRK phosphorylates and activates the stress-activated protein kinase activator, SEK-1
    • Rana, A, Gallo, K., Godowski, p., Hirai, S., Ohno, S., Zon, L., Kyriakis, J.M. and Avruch, J. (1996) The mixed lineage kinase SPRK phosphorylates and activates the stress-activated protein kinase activator, SEK-1. J. Biol. Chem., 271, 19025-19028.
    • (1996) J. Biol. Chem. , vol.271 , pp. 19025-19028
    • Rana, A.1    Gallo, K.2    Godowski, P.3    Hirai, S.4    Ohno, S.5    Zon, L.6    Kyriakis, J.M.7    Avruch, J.8
  • 39
    • 0025975312 scopus 로고
    • Cloning genes by complementation in yeast
    • Rose, M.D. and Broach, J.R. (1991) Cloning genes by complementation in yeast. Methods Enzymol., 194, 195-230.
    • (1991) Methods Enzymol. , vol.194 , pp. 195-230
    • Rose, M.D.1    Broach, J.R.2
  • 40
    • 0029860936 scopus 로고    scopus 로고
    • Ultraviolet light and osmotic stress: Activation of the JNK cascade through multiple growth factor and cytokine receptors
    • Rosette, C. and Karin, M. (1996) Ultraviolet light and osmotic stress: activation of the JNK cascade through multiple growth factor and cytokine receptors. Science, 274, 1194-1197.
    • (1996) Science , vol.274 , pp. 1194-1197
    • Rosette, C.1    Karin, M.2
  • 41
    • 0028022750 scopus 로고
    • A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins
    • Rouse, J., Cohen, P., Trigon, S., Morange, M., Alonso-Llamazares, A., Zamanillo, D., Hunt, T. and Nebreda, A.R. (1994) A novel kinase cascade triggered by stress and heat shock that stimulates MAPKAP kinase-2 and phosphorylation of the small heat shock proteins. Cell, 78, 1027-1037.
    • (1994) Cell , vol.78 , pp. 1027-1037
    • Rouse, J.1    Cohen, P.2    Trigon, S.3    Morange, M.4    Alonso-Llamazares, A.5    Zamanillo, D.6    Hunt, T.7    Nebreda, A.R.8
  • 42
    • 0030059508 scopus 로고    scopus 로고
    • Activation of MEK-1 and SEK-1 by Tpl-2 protooncoprotein, a novel MAP kinase kinase kinase
    • Salmeron, A., Ahmad, T.B., Carlile, G.W., Pappin, D., Narsimhan, R.P. and Ley, S.C. (1996) Activation of MEK-1 and SEK-1 by Tpl-2 protooncoprotein, a novel MAP kinase kinase kinase. EMBO J., 15, 817-826.
    • (1996) EMBO J. , vol.15 , pp. 817-826
    • Salmeron, A.1    Ahmad, T.B.2    Carlile, G.W.3    Pappin, D.4    Narsimhan, R.P.5    Ley, S.C.6
  • 43
  • 44
    • 0030968066 scopus 로고    scopus 로고
    • Mcs4 mitotic catastrophe suppressor regulates the fission yeast cell cycle through the Wik1-Wis1-Spc1 kinase cascade
    • Shiozaki, K., Shiozaki, M. and Russell, P. (1997) Mcs4 mitotic catastrophe suppressor regulates the fission yeast cell cycle through the Wik1-Wis1-Spc1 kinase cascade. Mol. Biol. Cell, 8, 409-419.
    • (1997) Mol. Biol. Cell , vol.8 , pp. 409-419
    • Shiozaki, K.1    Shiozaki, M.2    Russell, P.3
  • 45
    • 0028061674 scopus 로고
    • Signal transduction by tumor necrosis factor mediated by JNK protein kinases
    • Sluss, H.K., Barrett, T., Dérijard, B. and Davis, R.J. (1994) Signal transduction by tumor necrosis factor mediated by JNK protein kinases. Mol. Cell. Biol., 14, 8376-8384.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 8376-8384
    • Sluss, H.K.1    Barrett, T.2    Dérijard, B.3    Davis, R.J.4
  • 46
    • 0023636055 scopus 로고
    • Differential usage of three exons generates at least five different mRNAs encoding human leukocyte common antigens
    • Streuli, M., Hall, L.R., Saga, Y., Schlossman, S.F. and Saito, H. (1987) Differential usage of three exons generates at least five different mRNAs encoding human leukocyte common antigens. J. Exp. Med., 166, 1548-1566.
    • (1987) J. Exp. Med. , vol.166 , pp. 1548-1566
    • Streuli, M.1    Hall, L.R.2    Saga, Y.3    Schlossman, S.F.4    Saito, H.5
  • 47
    • 0024596736 scopus 로고
    • Selective inactivation of the exonuclease activity of bacteriophage T7 DNA polymerase by in vitro mutagenesis
    • Tabor, S. and Richardson, C.C. (1989) Selective inactivation of the exonuclease activity of bacteriophage T7 DNA polymerase by in vitro mutagenesis. J. Biol. Chem., 264, 6447-6458.
    • (1989) J. Biol. Chem. , vol.264 , pp. 6447-6458
    • Tabor, S.1    Richardson, C.C.2
  • 48
    • 0028823892 scopus 로고
    • Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast
    • Waskiewicz, A.J. and Cooper, J.A. (1995) Mitogen and stress response pathways: MAP kinase cascades and phosphatase regulation in mammals and yeast. Curr. Opin. Cell. Biol., 7, 798-805.
    • (1995) Curr. Opin. Cell. Biol. , vol.7 , pp. 798-805
    • Waskiewicz, A.J.1    Cooper, J.A.2
  • 49
    • 0030953080 scopus 로고    scopus 로고
    • Two-component signal transducers and MAPK cascades
    • Wurgler-Murphy, S.M. and Saito, H. (1997) Two-component signal transducers and MAPK cascades. Trends Biochem. Sci., 22, 172-176.
    • (1997) Trends Biochem. Sci. , vol.22 , pp. 172-176
    • Wurgler-Murphy, S.M.1    Saito, H.2
  • 51
    • 0028670788 scopus 로고
    • Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1
    • Yan, M., Dai, T., Deak, J.C., Kyriakis, J.M., Zon, L.I., Woodgett, J.R. and Templeton, D.J. (1994) Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1. Nature, 372, 798-800.
    • (1994) Nature , vol.372 , pp. 798-800
    • Yan, M.1    Dai, T.2    Deak, J.C.3    Kyriakis, J.M.4    Zon, L.I.5    Woodgett, J.R.6    Templeton, D.J.7
  • 52
    • 0028818395 scopus 로고
    • Mxi2, a mitogen-activated protein kinase that recognizes and phosphorylates Max protein
    • Zervos, A.S., Faccio, L., Gatto, J.P., Kyriakis, J.M. and Brent, R. (1995) Mxi2, a mitogen-activated protein kinase that recognizes and phosphorylates Max protein. Proc. Natl Acad. Sci. USA, 92, 10531-10534.
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 10531-10534
    • Zervos, A.S.1    Faccio, L.2    Gatto, J.P.3    Kyriakis, J.M.4    Brent, R.5


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