메뉴 건너뛰기




Volumn 118, Issue 12, 2008, Pages 3943-3953

Proliferation of human HCC cells and chemically induced mouse liver cancers requires JNK1-dependent p21 downregulation

Author keywords

[No Author keywords available]

Indexed keywords

P21 ACTIVATED KINASE; STRESS ACTIVATED PROTEIN KINASE 1;

EID: 57449109370     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI37156     Document Type: Article
Times cited : (279)

References (49)
  • 1
    • 33747830764 scopus 로고    scopus 로고
    • Hepatocellular carcinoma pathogenesis: From genes to environment
    • Farazi, P.A., and DePinho, R.A. 2006. Hepatocellular carcinoma pathogenesis: from genes to environment. Nat. Rev. Cancer. 6:674-687.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 674-687
    • Farazi, P.A.1    DePinho, R.A.2
  • 2
    • 0037462454 scopus 로고    scopus 로고
    • Liver tumor development. c-Jun antagonizes the proapoptotic activity of p53
    • Eferl, R., et al. 2003. Liver tumor development. c-Jun antagonizes the proapoptotic activity of p53. Cell. 112:181-192.
    • (2003) Cell , vol.112 , pp. 181-192
    • Eferl, R.1
  • 3
    • 34249334506 scopus 로고    scopus 로고
    • p38alpha suppresses normal and cancer cell proliferation by antagonizing the JNK-c-Jun pathway
    • Hui, L., et al. 2007. p38alpha suppresses normal and cancer cell proliferation by antagonizing the JNK-c-Jun pathway. Nat. Genet. 39:741-749.
    • (2007) Nat. Genet , vol.39 , pp. 741-749
    • Hui, L.1
  • 4
    • 21244472975 scopus 로고    scopus 로고
    • IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis
    • Maeda, S., Kamata, H., Luo, J.L., Leffert, H., and Karin, M. 2005. IKKbeta couples hepatocyte death to cytokine-driven compensatory proliferation that promotes chemical hepatocarcinogenesis. Cell. 121:977-990.
    • (2005) Cell , vol.121 , pp. 977-990
    • Maeda, S.1    Kamata, H.2    Luo, J.L.3    Leffert, H.4    Karin, M.5
  • 5
    • 33746032571 scopus 로고    scopus 로고
    • Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation
    • Sakurai, T., Maeda, S., Chang, L., and Karin, M. 2006. Loss of hepatic NF-kappa B activity enhances chemical hepatocarcinogenesis through sustained c-Jun N-terminal kinase 1 activation. Proc. Natl. Acad. Sci. U. S. A. 103:10544-10551.
    • (2006) Proc. Natl. Acad. Sci. U. S. A , vol.103 , pp. 10544-10551
    • Sakurai, T.1    Maeda, S.2    Chang, L.3    Karin, M.4
  • 6
    • 48649109203 scopus 로고    scopus 로고
    • Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis
    • Sakurai, T., et al. 2008. Hepatocyte necrosis induced by oxidative stress and IL-1 alpha release mediate carcinogen-induced compensatory proliferation and liver tumorigenesis. Cancer Cell. 14:156-165.
    • (2008) Cancer Cell , vol.14 , pp. 156-165
    • Sakurai, T.1
  • 7
    • 33847754623 scopus 로고    scopus 로고
    • The JNK signal transduction pathway
    • Weston, C.R., and Davis, R.J. 2007. The JNK signal transduction pathway. Curr. Opin. Cell Biol. 19:142-149.
    • (2007) Curr. Opin. Cell Biol , vol.19 , pp. 142-149
    • Weston, C.R.1    Davis, R.J.2
  • 8
    • 85047700485 scopus 로고    scopus 로고
    • Differential effects of JNK1 and JNK2 on signal specific induction of apoptosis
    • Hochedlinger, K., Wagner, E.F., and Sabapathy, K. 2002. Differential effects of JNK1 and JNK2 on signal specific induction of apoptosis. Oncogene. 21:2441-2445.
    • (2002) Oncogene , vol.21 , pp. 2441-2445
    • Hochedlinger, K.1    Wagner, E.F.2    Sabapathy, K.3
  • 9
    • 37349081594 scopus 로고    scopus 로고
    • Antagonistic control of cell fates by JNK and p38-MAPK signaling
    • Wada, T., et al. 2008. Antagonistic control of cell fates by JNK and p38-MAPK signaling. Cell Death Differ. 15:89-93.
    • (2008) Cell Death Differ , vol.15 , pp. 89-93
    • Wada, T.1
  • 10
    • 4444341881 scopus 로고    scopus 로고
    • Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation
    • Sabapathy, K., et al. 2004. Distinct roles for JNK1 and JNK2 in regulating JNK activity and c-Jun-dependent cell proliferation. Mol. Cell. 15:713-725.
    • (2004) Mol. Cell , vol.15 , pp. 713-725
    • Sabapathy, K.1
  • 11
    • 33748436341 scopus 로고    scopus 로고
    • JNK2 is a positive regulator of the cJun transcription factor
    • Jaeschke, A., et al. 2006. JNK2 is a positive regulator of the cJun transcription factor. Mol. Cell. 23:899-911.
    • (2006) Mol. Cell , vol.23 , pp. 899-911
    • Jaeschke, A.1
  • 12
    • 43049132158 scopus 로고    scopus 로고
    • Gadd45beta promotes hepatocyte survival during liver regeneration in mice by modulating JNK signaling
    • Papa, S., et al. 2008. Gadd45beta promotes hepatocyte survival during liver regeneration in mice by modulating JNK signaling. J. Clin. Invest. 118:1911-1923.
    • (2008) J. Clin. Invest , vol.118 , pp. 1911-1923
    • Papa, S.1
  • 13
    • 0037382797 scopus 로고    scopus 로고
    • c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration
    • Schwabe, R.F., et al. 2003. c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration. Hepatology. 37:824-832.
    • (2003) Hepatology , vol.37 , pp. 824-832
    • Schwabe, R.F.1
  • 14
    • 0037392942 scopus 로고    scopus 로고
    • The specificities of protein kinase inhibitors: An update
    • Bain, J., McLauchlan, H., Elliott, M., and Cohen, P. 2003. The specificities of protein kinase inhibitors: an update. Biochem. J. 371:199-204.
    • (2003) Biochem. J , vol.371 , pp. 199-204
    • Bain, J.1    McLauchlan, H.2    Elliott, M.3    Cohen, P.4
  • 15
    • 0036494195 scopus 로고    scopus 로고
    • Deficiency of c-Jun-NH(2)-terminal kinase-1 in mice enhances skin tumor development by 12-O-tetradecanoylphorbol-13-acetate
    • She, Q.B., Chen, N., Bode, A.M., Flavell, R.A., and Dong, Z. 2002. Deficiency of c-Jun-NH(2)-terminal kinase-1 in mice enhances skin tumor development by 12-O-tetradecanoylphorbol-13-acetate. Cancer Res. 62:1343-1348.
    • (2002) Cancer Res , vol.62 , pp. 1343-1348
    • She, Q.B.1    Chen, N.2    Bode, A.M.3    Flavell, R.A.4    Dong, Z.5
  • 16
    • 34547653108 scopus 로고    scopus 로고
    • c-Jun NH2-terminal kinase 1 plays a critical role in intestinal homeostasis and tumor suppression
    • Tong, C., et al. 2007. c-Jun NH2-terminal kinase 1 plays a critical role in intestinal homeostasis and tumor suppression. Am. J. Pathol. 171:297-303.
    • (2007) Am. J. Pathol , vol.171 , pp. 297-303
    • Tong, C.1
  • 17
    • 54049122614 scopus 로고    scopus 로고
    • Hasselblatt, P., Gresh, L., Kudo, H., Guinea-Viniegra, J., and Wagner, E.F. 2008. The role of the transcription factor AP-1 in colitis-associated and beta-catenin-dependent intestinal tumorigenesis in mice. Oncogene. 27:6102-6109. doi:10.1038/onc.2008.211.
    • Hasselblatt, P., Gresh, L., Kudo, H., Guinea-Viniegra, J., and Wagner, E.F. 2008. The role of the transcription factor AP-1 in colitis-associated and beta-catenin-dependent intestinal tumorigenesis in mice. Oncogene. 27:6102-6109. doi:10.1038/onc.2008.211.
  • 18
    • 48549093239 scopus 로고    scopus 로고
    • c-Jun NH2-terminal kinase 1 is a critical regulator for the development of gastric cancer in mice
    • Shibata, W., et al. 2008. c-Jun NH2-terminal kinase 1 is a critical regulator for the development of gastric cancer in mice. Cancer Res. 68:5031-5039.
    • (2008) Cancer Res , vol.68 , pp. 5031-5039
    • Shibata, W.1
  • 19
    • 0035872409 scopus 로고    scopus 로고
    • Suppression of skin tumorigenesis in c-Jun NH(2)-terminal kinase-2-deficient mice
    • Chen, N., et al. 2001. Suppression of skin tumorigenesis in c-Jun NH(2)-terminal kinase-2-deficient mice. Cancer Res. 61:3908-3912.
    • (2001) Cancer Res , vol.61 , pp. 3908-3912
    • Chen, N.1
  • 21
    • 34248141100 scopus 로고    scopus 로고
    • A cytokine-mediated link between innate immunity, inflammation, and cancer
    • Lin, W.W., and Karin, M. 2007. A cytokine-mediated link between innate immunity, inflammation, and cancer. J. Clin. Invest. 117:1175- 1183.
    • (2007) J. Clin. Invest , vol.117 , pp. 1175-1183
    • Lin, W.W.1    Karin, M.2
  • 22
    • 34247606483 scopus 로고    scopus 로고
    • Rewired ERK-JNK signaling pathways in melanoma
    • Lopez-Bergami, P., et al. 2007. Rewired ERK-JNK signaling pathways in melanoma. Cancer Cell. 11:447-460.
    • (2007) Cancer Cell , vol.11 , pp. 447-460
    • Lopez-Bergami, P.1
  • 23
    • 34249815200 scopus 로고    scopus 로고
    • Identification of the JNK signaling pathway as a functional target of the tumor suppressor PTEN
    • Vivanco, I., et al. 2007. Identification of the JNK signaling pathway as a functional target of the tumor suppressor PTEN. Cancer Cell. 11:555-569.
    • (2007) Cancer Cell , vol.11 , pp. 555-569
    • Vivanco, I.1
  • 24
    • 0037007208 scopus 로고    scopus 로고
    • Impaired postnatal hepa tocyte proliferation and liver regeneration in mice lacking c-jun in the liver
    • Behrens, A., et al. 2002. Impaired postnatal hepa tocyte proliferation and liver regeneration in mice lacking c-jun in the liver. EMBO J. 21:1782-1790.
    • (2002) EMBO J , vol.21 , pp. 1782-1790
    • Behrens, A.1
  • 25
    • 34347232205 scopus 로고    scopus 로고
    • Chronic inflammation associated with hepatitis C virus infection perturbs hepatic transforming growth factor beta signaling, promoting cirrhosis and hepatocellular carcinoma
    • Matsuzaki, K., et al. 2007. Chronic inflammation associated with hepatitis C virus infection perturbs hepatic transforming growth factor beta signaling, promoting cirrhosis and hepatocellular carcinoma. Hepatology. 46:48-57.
    • (2007) Hepatology , vol.46 , pp. 48-57
    • Matsuzaki, K.1
  • 26
    • 0030067581 scopus 로고    scopus 로고
    • Targeted in vivo expression of the cyclin-dependent kinase inhibitor p21 halts hepatocyte cell-cycle progression, postnatal liver development and regeneration
    • Wu, H., et al. 1996. Targeted in vivo expression of the cyclin-dependent kinase inhibitor p21 halts hepatocyte cell-cycle progression, postnatal liver development and regeneration. Genes Dev. 10:245-260.
    • (1996) Genes Dev , vol.10 , pp. 245-260
    • Wu, H.1
  • 27
    • 33747377165 scopus 로고    scopus 로고
    • c-Jun/AP-1 controls liver regeneration by repressing p53/p21 and p38 MAPK activity
    • Stepniak, E., et al. 2006. c-Jun/AP-1 controls liver regeneration by repressing p53/p21 and p38 MAPK activity. Genes Dev. 20:2306-2314.
    • (2006) Genes Dev , vol.20 , pp. 2306-2314
    • Stepniak, E.1
  • 28
    • 0027359827 scopus 로고
    • WAF1, a potential mediator of p53 tumor suppression
    • el-Deiry, W.S., et al. 1993. WAF1, a potential mediator of p53 tumor suppression. Cell. 75:817-825.
    • (1993) Cell , vol.75 , pp. 817-825
    • el-Deiry, W.S.1
  • 29
    • 18644371442 scopus 로고    scopus 로고
    • Negative regulation of the mammalian UV response by Myc through association with Miz-1
    • Herold, S., et al. 2002. Negative regulation of the mammalian UV response by Myc through association with Miz-1. Mol. Cell. 10:509-521.
    • (2002) Mol. Cell , vol.10 , pp. 509-521
    • Herold, S.1
  • 30
    • 0037126303 scopus 로고    scopus 로고
    • Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage
    • Seoane, J., Le, H.V., and Massague, J. 2002. Myc suppression of the p21(Cip1) Cdk inhibitor influences the outcome of the p53 response to DNA damage. Nature. 419:729-734.
    • (2002) Nature , vol.419 , pp. 729-734
    • Seoane, J.1    Le, H.V.2    Massague, J.3
  • 31
    • 33746617960 scopus 로고    scopus 로고
    • Skin epidermis lacking the c-Myc gene is resistant to Ras-driven tumorigenesis but can reacquire sensitivity upon additional loss of the p21Cip1 gene
    • Oskarsson, T., et al. 2006. Skin epidermis lacking the c-Myc gene is resistant to Ras-driven tumorigenesis but can reacquire sensitivity upon additional loss of the p21Cip1 gene. Genes Dev. 20:2024-2029.
    • (2006) Genes Dev , vol.20 , pp. 2024-2029
    • Oskarsson, T.1
  • 32
    • 17144371848 scopus 로고    scopus 로고
    • JNK2: A negative regulator of cellular proliferation
    • Sabapathy, K., and Wagner, E.F. 2004. JNK2: a negative regulator of cellular proliferation. Cell Cycle. 3:1520-1523.
    • (2004) Cell Cycle , vol.3 , pp. 1520-1523
    • Sabapathy, K.1    Wagner, E.F.2
  • 34
    • 0037113034 scopus 로고    scopus 로고
    • JNK1 modulates osteoclastogenesis through both c-Jun phosphorylation-dependent and -independent mechanisms
    • David, J.P., Sabapathy, K., Hoffmann, O., Idarraga, M.H., and Wagner, E.F. 2002. JNK1 modulates osteoclastogenesis through both c-Jun phosphorylation-dependent and -independent mechanisms. J. Cell. Sci. 115:4317-4325.
    • (2002) J. Cell. Sci , vol.115 , pp. 4317-4325
    • David, J.P.1    Sabapathy, K.2    Hoffmann, O.3    Idarraga, M.H.4    Wagner, E.F.5
  • 35
    • 0036150184 scopus 로고    scopus 로고
    • Receptor activator of NFkappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6
    • Mizukami, J., et al. 2002. Receptor activator of NFkappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6. Mol. Cell. Biol. 22:992-1000.
    • (2002) Mol. Cell. Biol , vol.22 , pp. 992-1000
    • Mizukami, J.1
  • 36
    • 36749084608 scopus 로고    scopus 로고
    • Hepatocyte survival in acute hepatitis is due to c-Jun/AP-1-dependent expression of inducible nitric oxide synthase
    • Hasselblatt, P., Rath, M., Komnenovic, V., Zatloukal, K., and Wagner, E.F. 2007. Hepatocyte survival in acute hepatitis is due to c-Jun/AP-1-dependent expression of inducible nitric oxide synthase. Proc. Natl. Acad. Sci. U. S. A. 104:17105-17110.
    • (2007) Proc. Natl. Acad. Sci. U. S. A , vol.104 , pp. 17105-17110
    • Hasselblatt, P.1    Rath, M.2    Komnenovic, V.3    Zatloukal, K.4    Wagner, E.F.5
  • 37
    • 23044453047 scopus 로고    scopus 로고
    • Inhibition of c-Jun-N-terminal-kinase sensitizes tumor cells to CD95-induced apoptosis and induces G2/M cell cycle arrest
    • Kuntzen, C., et al. 2005. Inhibition of c-Jun-N-terminal-kinase sensitizes tumor cells to CD95-induced apoptosis and induces G2/M cell cycle arrest. Cancer Res. 65:6780-6788.
    • (2005) Cancer Res , vol.65 , pp. 6780-6788
    • Kuntzen, C.1
  • 38
    • 33847147710 scopus 로고    scopus 로고
    • c-Jun NH2-terminal kinase decreases ubiquitination and promotes stabilization of p21(WAF1/CIP1) in K562 cell
    • Fan, Y., et al. 2007. c-Jun NH2-terminal kinase decreases ubiquitination and promotes stabilization of p21(WAF1/CIP1) in K562 cell. Biochem. Biophys. Res. Commun. 355:263-268.
    • (2007) Biochem. Biophys. Res. Commun , vol.355 , pp. 263-268
    • Fan, Y.1
  • 39
    • 0037119470 scopus 로고    scopus 로고
    • The stress-activated protein kinases p38 alpha and JNK1 stabilize p21(Cip1) by phosphorylation
    • Kim, G.Y., et al. 2002. The stress-activated protein kinases p38 alpha and JNK1 stabilize p21(Cip1) by phosphorylation. J. Biol. Chem. 277:29792-29802.
    • (2002) J. Biol. Chem , vol.277 , pp. 29792-29802
    • Kim, G.Y.1
  • 41
    • 0035912763 scopus 로고    scopus 로고
    • Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis
    • Bowman, T., et al. 2001. Stat3-mediated Myc expression is required for Src transformation and PDGF-induced mitogenesis. Proc. Natl. Acad. Sci. U. S. A. 98:7319-7324.
    • (2001) Proc. Natl. Acad. Sci. U. S. A , vol.98 , pp. 7319-7324
    • Bowman, T.1
  • 42
    • 33747616250 scopus 로고    scopus 로고
    • Overexpression of c-myc in pancreatic cancer caused by ectopic activation of NFATc1 and the Ca2+/calcineurin signaling pathway
    • Buchholz, M., et al. 2006. Overexpression of c-myc in pancreatic cancer caused by ectopic activation of NFATc1 and the Ca2+/calcineurin signaling pathway. EMBO J. 25:3714-3724.
    • (2006) EMBO J , vol.25 , pp. 3714-3724
    • Buchholz, M.1
  • 43
    • 0028609209 scopus 로고
    • JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation
    • Kallunki, T., et al. 1994. JNK2 contains a specificity-determining region responsible for efficient c-Jun binding and phosphorylation. Genes Dev. 8:2996-3007.
    • (1994) Genes Dev , vol.8 , pp. 2996-3007
    • Kallunki, T.1
  • 44
    • 15444370235 scopus 로고    scopus 로고
    • Identification of a specific domain responsible for JNK2alpha2 autophosphorylation
    • Cui, J., et al. 2005. Identification of a specific domain responsible for JNK2alpha2 autophosphorylation. J. Biol. Chem. 280:9913-9920.
    • (2005) J. Biol. Chem , vol.280 , pp. 9913-9920
    • Cui, J.1
  • 45
    • 34249075147 scopus 로고    scopus 로고
    • MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
    • Engelman, J.A., et al. 2007. MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling. Science. 316:1039-1043.
    • (2007) Science , vol.316 , pp. 1039-1043
    • Engelman, J.A.1
  • 46
    • 35348822482 scopus 로고    scopus 로고
    • Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies
    • Stommel, J.M., et al. 2007. Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies. Science. 318:287-290.
    • (2007) Science , vol.318 , pp. 287-290
    • Stommel, J.M.1
  • 47
    • 33749017926 scopus 로고    scopus 로고
    • Phase II study of sorafenib in patients with advanced hepatocellular carcinoma
    • Abou-Alfa, G.K., et al. 2006. Phase II study of sorafenib in patients with advanced hepatocellular carcinoma. J. Clin. Oncol. 24:4293-4300.
    • (2006) J. Clin. Oncol , vol.24 , pp. 4293-4300
    • Abou-Alfa, G.K.1
  • 48
    • 47949116252 scopus 로고    scopus 로고
    • Sorafenib in advanced hepatocellular carcinoma
    • Llovet, J.M., et al. 2008. Sorafenib in advanced hepatocellular carcinoma. N. Engl. J. Med. 359:378-390.
    • (2008) N. Engl. J. Med , vol.359 , pp. 378-390
    • Llovet, J.M.1
  • 49
    • 0141724805 scopus 로고    scopus 로고
    • A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia
    • Borsello, T., et al. 2003. A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia. Nat. Med. 9:1180-1186.
    • (2003) Nat. Med , vol.9 , pp. 1180-1186
    • Borsello, T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.