-
1
-
-
0030613249
-
TβRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling
-
Abdollah S., Macias-Silva M., Tsukazaki T., Hayashi H., Attisano L., Wrana J.L. TβRI phosphorylation of Smad2 on Ser465 and Ser467 is required for Smad2-Smad4 complex formation and signaling. J. Biol. Chem. 272:1997;27678-27685.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 27678-27685
-
-
Abdollah, S.1
Macias-Silva, M.2
Tsukazaki, T.3
Hayashi, H.4
Attisano, L.5
Wrana, J.L.6
-
2
-
-
0036051343
-
Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-β
-
Abreu J.G., Ketpura N.I., Reversade B., De Robertis E.M. Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-β Nat. Cell Biol. 4:2002;599-604.
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 599-604
-
-
Abreu, J.G.1
Ketpura, N.I.2
Reversade, B.3
De Robertis, E.M.4
-
4
-
-
0036119191
-
SMIF, a Smad4-interacting protein that functions as a co-activator in TGFβ signalling
-
Bai R.Y., Koester C., Ouyang T., Hahn S.A., Hammerschmidt M., Peschel C., Duyster J. SMIF, a Smad4-interacting protein that functions as a co-activator in TGFβ signalling. Nat. Cell Biol. 4:2002;181-190.
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 181-190
-
-
Bai, R.Y.1
Koester, C.2
Ouyang, T.3
Hahn, S.A.4
Hammerschmidt, M.5
Peschel, C.6
Duyster, J.7
-
5
-
-
0036399170
-
Extracellular regulation of BMP signaling in vertebrates: A cocktail of modulators
-
Balemans W., Van Hul W. Extracellular regulation of BMP signaling in vertebrates. a cocktail of modulators Dev. Biol. 250:2002;231-250.
-
(2002)
Dev. Biol.
, vol.250
, pp. 231-250
-
-
Balemans, W.1
Van Hul, W.2
-
6
-
-
0035185853
-
Transforming growth factor-β1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism
-
Bhowmick N.A., Ghiassi M., Bakin A., Aakre M., Lundquist C.A., Engel M.E., Arteaga C.L., Moses H.L. Transforming growth factor-β1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism. Mol. Biol. Cell. 12:2001;27-36.
-
(2001)
Mol. Biol. Cell
, vol.12
, pp. 27-36
-
-
Bhowmick, N.A.1
Ghiassi, M.2
Bakin, A.3
Aakre, M.4
Lundquist, C.A.5
Engel, M.E.6
Arteaga, C.L.7
Moses, H.L.8
-
7
-
-
0034650266
-
A mechanism of suppression of TGF-β/SMAD signaling by NF-kappa B/RelA
-
Bitzer M., von Gersdorff G., Liang D., Dominguez-Rosales A., Beg A.A., Rojkind M., Bottinger E.P. A mechanism of suppression of TGF-β/SMAD signaling by NF-kappa B/RelA. Genes Dev. 14:2000;187-197.
-
(2000)
Genes Dev.
, vol.14
, pp. 187-197
-
-
Bitzer, M.1
Von Gersdorff, G.2
Liang, D.3
Dominguez-Rosales, A.4
Beg, A.A.5
Rojkind, M.6
Bottinger, E.P.7
-
8
-
-
0036069143
-
The 1.1 Å crystal structure of human TGF-β type II receptor ligand binding domain
-
Boesen C.C., Radaev S., Motyka S.A., Patamawenu A., Sun P.D. The 1.1 Å crystal structure of human TGF-β type II receptor ligand binding domain. Structure. 10:2002;913-919.
-
(2002)
Structure
, vol.10
, pp. 913-919
-
-
Boesen, C.C.1
Radaev, S.2
Motyka, S.A.3
Patamawenu, A.4
Sun, P.D.5
-
9
-
-
0034976149
-
TGF-β induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation
-
Bonni S., Wang H.R., Causing C.G., Kavsak P., Stroschein S.L., Luo K., Wrana J.L. TGF-β induces assembly of a Smad2-Smurf2 ubiquitin ligase complex that targets SnoN for degradation. Nat. Cell Biol. 3:2001;587-595.
-
(2001)
Nat. Cell Biol.
, vol.3
, pp. 587-595
-
-
Bonni, S.1
Wang, H.R.2
Causing, C.G.3
Kavsak, P.4
Stroschein, S.L.5
Luo, K.6
Wrana, J.L.7
-
10
-
-
0033605704
-
Requirement of type III TGF-β receptor for endocardial cell transformation in the heart
-
a
-
Brown C.B., Boyer A.S., Runyan R.B., Barnett J.V. Requirement of type III TGF-β receptor for endocardial cell transformation in the heart. Science. 283:1999;2080-2082. a.
-
(1999)
Science
, vol.283
, pp. 2080-2082
-
-
Brown, C.B.1
Boyer, A.S.2
Runyan, R.B.3
Barnett, J.V.4
-
11
-
-
0033605559
-
MEKK-1, a component of the stress (stress-activated protein kinase/c-Jun N-terminal kinase) pathway, can selectively activate Smad2-mediated transcriptional activation in endothelial cells
-
b
-
Brown J.D., DiChiara M.R., Anderson K.R., Gimbrone M.A. Jr., Topper J.N. MEKK-1, a component of the stress (stress-activated protein kinase/c-Jun N-terminal kinase) pathway, can selectively activate Smad2-mediated transcriptional activation in endothelial cells. J. Biol. Chem. 274:1999;8797-8805. b.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 8797-8805
-
-
Brown, J.D.1
DiChiara, M.R.2
Anderson, K.R.3
Gimbrone M.A., Jr.4
Topper, J.N.5
-
12
-
-
0032577276
-
Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton
-
Brunet L.J., McMahon J.A., McMahon A.P., Harland R.M. Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton. Science. 280:1998;1455-1457.
-
(1998)
Science
, vol.280
, pp. 1455-1457
-
-
Brunet, L.J.1
McMahon, J.A.2
McMahon, A.P.3
Harland, R.M.4
-
13
-
-
0035123060
-
The L3 loop and C-terminal phosphorylation jointly define Smad protein trimerization
-
Chacko B.M., Qin B., Correia J.J., Lam S.S., de Caestecker M.P., Lin K. The L3 loop and C-terminal phosphorylation jointly define Smad protein trimerization. Nat. Struct. Biol. 8:2001;248-253.
-
(2001)
Nat. Struct. Biol.
, vol.8
, pp. 248-253
-
-
Chacko, B.M.1
Qin, B.2
Correia, J.J.3
Lam, S.S.4
De Caestecker, M.P.5
Lin, K.6
-
14
-
-
0038820062
-
Features of a Smad3 MH1-DNA complex: Roles of water and zinc in DNA binding at 2.4 Å resolution
-
in press
-
Chai J., Wu J.-W., Massagué J., Pavletich N.P., Shi Y. Features of a Smad3 MH1-DNA complex. roles of water and zinc in DNA binding at 2.4 Å resolution J. Biol. Chem. in press:2003.
-
(2003)
J. Biol. Chem.
-
-
Chai, J.1
Wu, J.-W.2
Massagué, J.3
Pavletich, N.P.4
Shi, Y.5
-
15
-
-
0037067653
-
E2F4/5 and p107 as Smad cofactors linking the TGFβ receptor to c-myc repression
-
Chen C.R., Kang Y., Siegel P.M., Massagué J. E2F4/5 and p107 as Smad cofactors linking the TGFβ receptor to c-myc repression. Cell. 110:2002;19-32.
-
(2002)
Cell
, vol.110
, pp. 19-32
-
-
Chen, C.R.1
Kang, Y.2
Siegel, P.M.3
Massagué, J.4
-
16
-
-
0032528055
-
Determinants of specificity in the TGF-β signal transduction
-
Chen Y.-G., Hata A., Lo R.S., Wotton D., Shi Y., Pavletich N., Massagué J. Determinants of specificity in the TGF-β signal transduction. Genes Dev. 12:1998;2144-2152.
-
(1998)
Genes Dev.
, vol.12
, pp. 2144-2152
-
-
Chen, Y.-G.1
Hata, A.2
Lo, R.S.3
Wotton, D.4
Shi, Y.5
Pavletich, N.6
Massagué, J.7
-
17
-
-
0037229696
-
EGF-CFC proteins are essential coreceptors for the TGF-β signals Vg1 and GDF1
-
Cheng S.K., Olale F., Bennett J.T., Brivanlou A.H., Schier A.F. EGF-CFC proteins are essential coreceptors for the TGF-β signals Vg1 and GDF1. Genes Dev. 17:2003;31-36.
-
(2003)
Genes Dev.
, vol.17
, pp. 31-36
-
-
Cheng, S.K.1
Olale, F.2
Bennett, J.T.3
Brivanlou, A.H.4
Schier, A.F.5
-
18
-
-
0031042082
-
Physical basis of a protein-DNA recognition code
-
Choo Y., Klug A. Physical basis of a protein-DNA recognition code. Curr. Opin. Struct. Biol. 7:1997;117-125.
-
(1997)
Curr. Opin. Struct. Biol.
, vol.7
, pp. 117-125
-
-
Choo, Y.1
Klug, A.2
-
19
-
-
0033996038
-
STRAP and Smad7 synergize in the inhibition of transforming growth factor β signaling
-
Datta P.K., Moses H.L. STRAP and Smad7 synergize in the inhibition of transforming growth factor β signaling. Mol. Cell. Biol. 20:2000;3157-3167.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 3157-3167
-
-
Datta, P.K.1
Moses, H.L.2
-
20
-
-
0035721752
-
Bone morphogenetic proteins, genetics and the pathophysiology of primary pulmonary hypertension
-
De Caestecker M., Meyrick B. Bone morphogenetic proteins, genetics and the pathophysiology of primary pulmonary hypertension. Respir. Res. 2:2001;193-197.
-
(2001)
Respir. Res.
, vol.2
, pp. 193-197
-
-
De Caestecker, M.1
Meyrick, B.2
-
21
-
-
0034612231
-
Transforming growth factor β-inducible independent binding of SMAD to the Smad7 promoter
-
Denissova N.G., Pouponnot C., Long J., He D., Liu F. Transforming growth factor β-inducible independent binding of SMAD to the Smad7 promoter. Proc. Natl. Acad. Sci. USA. 97:2000;6397-6402.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 6397-6402
-
-
Denissova, N.G.1
Pouponnot, C.2
Long, J.3
He, D.4
Liu, F.5
-
22
-
-
0032101178
-
Direct binding of Smad3 and Smad4 to critical TGFβ-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene
-
Dennler S., Itoh S., Vivien D., ten Dijke P., Huet S., Gauthier J.-M. Direct binding of Smad3 and Smad4 to critical TGFβ-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene. EMBO J. 17:1998;3091-3100.
-
(1998)
EMBO J.
, vol.17
, pp. 3091-3100
-
-
Dennler, S.1
Itoh, S.2
Vivien, D.3
Ten Dijke, P.4
Huet, S.5
Gauthier, J.-M.6
-
23
-
-
16144366751
-
Nomenclature: Vertebrate mediators of TGFβ family signals
-
Derynck R., Gelbart W.M., Harland R.M., Heldin C.-H., Kern S.E., Massagué J., Melton D.A., Mlodzik M., Padgett R.W., Roberts A.B.et al. Nomenclature. vertebrate mediators of TGFβ family signals Cell. 87:1996;173.
-
(1996)
Cell
, vol.87
, pp. 173
-
-
Derynck, R.1
Gelbart, W.M.2
Harland, R.M.3
Heldin, C.-H.4
Kern, S.E.5
Massagué, J.6
Melton, D.A.7
Mlodzik, M.8
Padgett, R.W.9
Roberts, A.B.10
-
24
-
-
0032442852
-
Smads: Transcriptional activators of TGF-β responses
-
Derynck R., Zhang Y., Feng X.H. Smads. transcriptional activators of TGF-β responses Cell. 95:1998;737-740.
-
(1998)
Cell
, vol.95
, pp. 737-740
-
-
Derynck, R.1
Zhang, Y.2
Feng, X.H.3
-
26
-
-
0035918274
-
Smurf1 interacts with transforming growth factor-β type I receptor through Smad7 and induces receptor degradation
-
Ebisawa T., Fukuchi M., Murakami G., Chiba T., Tanaka K., Imamura T., Miyazono K. Smurf1 interacts with transforming growth factor-β type I receptor through Smad7 and induces receptor degradation. J. Biol. Chem. 276:2001;12477-12480.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 12477-12480
-
-
Ebisawa, T.1
Fukuchi, M.2
Murakami, G.3
Chiba, T.4
Tanaka, K.5
Imamura, T.6
Miyazono, K.7
-
27
-
-
0030926005
-
A kinase subdomain of transforming growth factor-β (TGF-β) type I receptor determines the TGF-β intracellular signaling specificity
-
Feng X.-H., Derynck R. A kinase subdomain of transforming growth factor-β (TGF-β) type I receptor determines the TGF-β intracellular signaling specificity. EMBO J. 16:1997;3912-3923.
-
(1997)
EMBO J.
, vol.16
, pp. 3912-3923
-
-
Feng, X.-H.1
Derynck, R.2
-
28
-
-
0034596993
-
Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-β
-
Feng X.H., Lin X., Derynck R. Smad2, Smad3 and Smad4 cooperate with Sp1 to induce p15(Ink4B) transcription in response to TGF-β EMBO J. 19:2000;5178-5193.
-
(2000)
EMBO J.
, vol.19
, pp. 5178-5193
-
-
Feng, X.H.1
Lin, X.2
Derynck, R.3
-
29
-
-
0034767430
-
Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins
-
Fukuchi M., Imamura T., Chiba T., Ebisawa T., Kawabata M., Tanaka K., Miyazono K. Ligand-dependent degradation of Smad3 by a ubiquitin ligase complex of ROC1 and associated proteins. Mol. Biol. Cell. 12:2001;1431-1443.
-
(2001)
Mol. Biol. Cell
, vol.12
, pp. 1431-1443
-
-
Fukuchi, M.1
Imamura, T.2
Chiba, T.3
Ebisawa, T.4
Kawabata, M.5
Tanaka, K.6
Miyazono, K.7
-
30
-
-
0034947962
-
Axin facilitates Smad3 activation in the transforming growth factor β signaling pathway
-
Furuhashi M., Yagi K., Yamamoto H., Furukawa Y., Shimada S., Nakamura Y., Kikuchi A., Miyazono K., Kato M. Axin facilitates Smad3 activation in the transforming growth factor β signaling pathway. Mol. Cell. Biol. 21:2001;5132-5141.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 5132-5141
-
-
Furuhashi, M.1
Yagi, K.2
Yamamoto, H.3
Furukawa, Y.4
Shimada, S.5
Nakamura, Y.6
Kikuchi, A.7
Miyazono, K.8
Kato, M.9
-
31
-
-
0033052269
-
Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis
-
Gong Y., Krakow D., Marcelino J., Wilkin D., Chitayat D., Babul-Hirji R., Hudgins L., Cremers C.W., Cremers F.P., Brunner H.G.et al. Heterozygous mutations in the gene encoding noggin affect human joint morphogenesis. Nat. Genet. 21:1999;302-304.
-
(1999)
Nat. Genet.
, vol.21
, pp. 302-304
-
-
Gong, Y.1
Krakow, D.2
Marcelino, J.3
Wilkin, D.4
Chitayat, D.5
Babul-Hirji, R.6
Hudgins, L.7
Cremers, C.W.8
Cremers, F.P.9
Brunner, H.G.10
-
32
-
-
0033279841
-
Transport between the cell nucleus and the cytoplasm
-
Gorlich D., Kutay U. Transport between the cell nucleus and the cytoplasm. Annu. Rev. Cell Dev. Biol. 15:1999;607-660.
-
(1999)
Annu. Rev. Cell Dev. Biol.
, vol.15
, pp. 607-660
-
-
Gorlich, D.1
Kutay, U.2
-
33
-
-
0037007226
-
Balancing the activation state of the endothelium via two distinct TGF-β type I receptors
-
Goumans M.J., Valdimarsdottir G., Itoh S., Rosendahl A., Sideras P., ten Dijke P. Balancing the activation state of the endothelium via two distinct TGF-β type I receptors. EMBO J. 21:2002;1743-1753.
-
(2002)
EMBO J.
, vol.21
, pp. 1743-1753
-
-
Goumans, M.J.1
Valdimarsdottir, G.2
Itoh, S.3
Rosendahl, A.4
Sideras, P.5
Ten Dijke, P.6
-
34
-
-
0034603078
-
Identification of a binding site on the type II activin receptor for activin and inhibin
-
Gray P.C., Greenwald J., Blount A.L., Kunitake K.S., Donaldson C.J., Choe S., Vale W. Identification of a binding site on the type II activin receptor for activin and inhibin. J. Biol. Chem. 275:2000;3206-3212.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 3206-3212
-
-
Gray, P.C.1
Greenwald, J.2
Blount, A.L.3
Kunitake, K.S.4
Donaldson, C.J.5
Choe, S.6
Vale, W.7
-
35
-
-
0032899751
-
Three-finger toxin fold for the extracellular ligand-binding domain of the type II activin receptor serine kinase
-
Greenwald J., Fischer W.H., Vale W.W., Choe S. Three-finger toxin fold for the extracellular ligand-binding domain of the type II activin receptor serine kinase. Nat. Struct. Biol. 6:1999;18-22.
-
(1999)
Nat. Struct. Biol.
, vol.6
, pp. 18-22
-
-
Greenwald, J.1
Fischer, W.H.2
Vale, W.W.3
Choe, S.4
-
36
-
-
0037351880
-
The BMP7/ActRII extracellular domain complex provides new insights into the cooperative nature of receptor assembly
-
Greenwald J., Groppe P., Gray P., Wiater E., Kwiatkowski W., Vale W.W., Choe S. The BMP7/ActRII extracellular domain complex provides new insights into the cooperative nature of receptor assembly. Mol. Cell. 11:2003;605-617.
-
(2003)
Mol. Cell
, vol.11
, pp. 605-617
-
-
Greenwald, J.1
Groppe, P.2
Gray, P.3
Wiater, E.4
Kwiatkowski, W.5
Vale, W.W.6
Choe, S.7
-
37
-
-
0036301992
-
Nuclear exclusion of Smad2 is a mechanism leading to loss of competence
-
Grimm O.H., Gurdon J.B. Nuclear exclusion of Smad2 is a mechanism leading to loss of competence. Nat. Cell Biol. 4:2002;519-522.
-
(2002)
Nat. Cell Biol.
, vol.4
, pp. 519-522
-
-
Grimm, O.H.1
Gurdon, J.B.2
-
38
-
-
0035896039
-
MH1 domain of Smad is a degraded homing endonuclease
-
Grishin N.V. MH1 domain of Smad is a degraded homing endonuclease. J. Mol. Biol. 307:2001;31-37.
-
(2001)
J. Mol. Biol.
, vol.307
, pp. 31-37
-
-
Grishin, N.V.1
-
39
-
-
0036753547
-
Control of Smad7 stability by competition between acetylation and ubiquitination
-
Gronroos E., Hellman U., Heldin C.H., Ericsson J. Control of Smad7 stability by competition between acetylation and ubiquitination. Mol. Cell. 10:2002;483-493.
-
(2002)
Mol. Cell
, vol.10
, pp. 483-493
-
-
Gronroos, E.1
Hellman, U.2
Heldin, C.H.3
Ericsson, J.4
-
40
-
-
0037069653
-
Structural basis of BMP signalling inhibition by the cystine knot protein Noggin
-
Groppe J., Greenwald J., Wiater E., Rodriguez-Leon J., Economides A.N., Kwiatkowski W., Affolter M., Vale W.W., Belmonte J.C., Choe S. Structural basis of BMP signalling inhibition by the cystine knot protein Noggin. Nature. 420:2002;636-642.
-
(2002)
Nature
, vol.420
, pp. 636-642
-
-
Groppe, J.1
Greenwald, J.2
Wiater, E.3
Rodriguez-Leon, J.4
Economides, A.N.5
Kwiatkowski, W.6
Affolter, M.7
Vale, W.W.8
Belmonte, J.C.9
Choe, S.10
-
41
-
-
0035932414
-
Developmental biology. A twist on embryonic signalling
-
Harland R.M. Developmental biology. A twist on embryonic signalling. Nature. 410:2001;423-424.
-
(2001)
Nature
, vol.410
, pp. 423-424
-
-
Harland, R.M.1
-
42
-
-
0036177334
-
Crystal structure of the human TβR2 ectodomain-TGF-β3 complex
-
Hart P.J., Deep S., Taylor A.B., Shu Z., Hinck C.S., Hinck A.P. Crystal structure of the human TβR2 ectodomain-TGF-β3 complex. Nat. Struct. Biol. 9:2002;203-208.
-
(2002)
Nat. Struct. Biol.
, vol.9
, pp. 203-208
-
-
Hart, P.J.1
Deep, S.2
Taylor, A.B.3
Shu, Z.4
Hinck, C.S.5
Hinck, A.P.6
-
43
-
-
0031964859
-
Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumour suppressor
-
Hata A., Lagna G., Massagué J., Hemmati-Brivalou A. Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumour suppressor. Genes Dev. 12:1998;186-197.
-
(1998)
Genes Dev.
, vol.12
, pp. 186-197
-
-
Hata, A.1
Lagna, G.2
Massagué, J.3
Hemmati-Brivalou, A.4
-
44
-
-
0037144841
-
TGF-β receptor internalization into EEA1-enriched early endosomes: Role in signaling to Smad2
-
Hayes S., Chawla A., Corvera S. TGF-β receptor internalization into EEA1-enriched early endosomes. role in signaling to Smad2 J. Cell Biol. 158:2002;1239-1249.
-
(2002)
J. Cell Biol.
, vol.158
, pp. 1239-1249
-
-
Hayes, S.1
Chawla, A.2
Corvera, S.3
-
45
-
-
0035355473
-
The adaptor molecule Disabled-2 links the transforming growth factor β receptors to the Smad pathway
-
Hocevar B.A., Smine A., Xu X.X., Howe P.H. The adaptor molecule Disabled-2 links the transforming growth factor β receptors to the Smad pathway. EMBO J. 20:2001;2789-2801.
-
(2001)
EMBO J.
, vol.20
, pp. 2789-2801
-
-
Hocevar, B.A.1
Smine, A.2
Xu, X.X.3
Howe, P.H.4
-
46
-
-
0033559209
-
Dominant-negative Smad2 mutants inhibit activin/Vg1 signaling and disrupt axis formation in Xenopus
-
Hoodless P.A., Tsukazaki T., Nishimatsu S., Attisano L., Wrana J.L., Thomsen G.H. Dominant-negative Smad2 mutants inhibit activin/Vg1 signaling and disrupt axis formation in Xenopus. Dev. Biol. 207:1999;364-379.
-
(1999)
Dev. Biol.
, vol.207
, pp. 364-379
-
-
Hoodless, P.A.1
Tsukazaki, T.2
Nishimatsu, S.3
Attisano, L.4
Wrana, J.L.5
Thomsen, G.H.6
-
47
-
-
0033524943
-
Crystal structure of the cytoplasmic domain of the type I TGF-β receptor in complex with FKBP12
-
Huse M., Chen Y.-G., Massagué J., Kuriyan J. Crystal structure of the cytoplasmic domain of the type I TGF-β receptor in complex with FKBP12. Cell. 96:1999;425-436.
-
(1999)
Cell
, vol.96
, pp. 425-436
-
-
Huse, M.1
Chen, Y.-G.2
Massagué, J.3
Kuriyan, J.4
-
48
-
-
0034796457
-
The TGF-β receptor activation process: An inhibitor- to substrate-binding switch
-
Huse M., Muir T.W., Xu L., Chen Y.-G., Kuriyan J., Massagué J. The TGF-β receptor activation process. an inhibitor- to substrate-binding switch Mol. Cell. 8:2001;671-682.
-
(2001)
Mol. Cell
, vol.8
, pp. 671-682
-
-
Huse, M.1
Muir, T.W.2
Xu, L.3
Chen, Y.-G.4
Kuriyan, J.5
Massagué, J.6
-
49
-
-
0037185010
-
Stoichiometry of active Smad-transcription factor complexes on DNA
-
Inman G.J., Hill C.S. Stoichiometry of active Smad-transcription factor complexes on DNA. J. Biol. Chem. 277:2002;51008-51016.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 51008-51016
-
-
Inman, G.J.1
Hill, C.S.2
-
50
-
-
0036670339
-
Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-β receptor activity
-
Inman G.J., Nicolas F.J., Hill C.S. Nucleocytoplasmic shuttling of Smads 2, 3, and 4 permits sensing of TGF-β receptor activity. Mol. Cell. 10:2002;283-294.
-
(2002)
Mol. Cell
, vol.10
, pp. 283-294
-
-
Inman, G.J.1
Nicolas, F.J.2
Hill, C.S.3
-
51
-
-
0034093738
-
Smad6 is a Smad1/5-induced smad inhibitor. Characterization of bone morphogenetic protein-responsive element in the mouse Smad6 promoter
-
Ishida W., Hamamoto T., Kusanagi K., Yagi K., Kawabata M., Takehara K., Sampath T.K., Kato M., Miyazono K. Smad6 is a Smad1/5-induced smad inhibitor. Characterization of bone morphogenetic protein-responsive element in the mouse Smad6 promoter. J. Biol. Chem. 275:2000;6075-6079.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 6075-6079
-
-
Ishida, W.1
Hamamoto, T.2
Kusanagi, K.3
Yagi, K.4
Kawabata, M.5
Takehara, K.6
Sampath, T.K.7
Kato, M.8
Miyazono, K.9
-
52
-
-
0035422199
-
Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads
-
Itoh F., Asao H., Sugamura K., Heldin C.-H., ten Dijke P., Itoh S. Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads. EMBO J. 20:2001;4132-4142.
-
(2001)
EMBO J.
, vol.20
, pp. 4132-4142
-
-
Itoh, F.1
Asao, H.2
Sugamura, K.3
Heldin, C.-H.4
Ten Dijke, P.5
Itoh, S.6
-
53
-
-
0032582672
-
Transforming growth factor β1 induces nuclear export of inhibitory Smad7
-
Itoh S., Landstrom M., Hermansson A., Itoh F., Heldin C.-H., Heldin N.-E., ten Dijke P. Transforming growth factor β1 induces nuclear export of inhibitory Smad7. J. Biol. Chem. 273:1998;29195-29201.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 29195-29201
-
-
Itoh, S.1
Landstrom, M.2
Hermansson, A.3
Itoh, F.4
Heldin, C.-H.5
Heldin, N.-E.6
Ten Dijke, P.7
-
54
-
-
0037423374
-
Elucidation of Smad requirement in transforming growth factor-β type I receptor-induced responses
-
Itoh S., Thorikay M., Kowanetz M., Moustakas A., Itoh F., Heldin C.H., ten Dijke P. Elucidation of Smad requirement in transforming growth factor-β type I receptor-induced responses. J. Biol. Chem. 278:2003;3751-3761.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 3751-3761
-
-
Itoh, S.1
Thorikay, M.2
Kowanetz, M.3
Moustakas, A.4
Itoh, F.5
Heldin, C.H.6
Ten Dijke, P.7
-
55
-
-
0034731334
-
Distinct oligomeric states of SMAD proteins in the TGF-β pathway
-
Jayaraman L., Massagué J. Distinct oligomeric states of SMAD proteins in the TGF-β pathway. J. Biol. Chem. 275:2000;40710-40717.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 40710-40717
-
-
Jayaraman, L.1
Massagué, J.2
-
56
-
-
0033575263
-
Interaction of Smad complexes with tripartite DNA-binding sites
-
Johnson K., Kirkpatrick H., Comer A., Hoffmann F.M., Laughon A. Interaction of Smad complexes with tripartite DNA-binding sites. J. Biol. Chem. 274:1999;20709-20716.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 20709-20716
-
-
Johnson, K.1
Kirkpatrick, H.2
Comer, A.3
Hoffmann, F.M.4
Laughon, A.5
-
57
-
-
0038369998
-
A self-enabling TGFβ response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells
-
Kang Y., Chen C.-R., Massagué J. A self-enabling TGFβ response coupled to stress signaling. Smad engages stress response factor ATF3 for Id1 repression in epithelial cells Mol. Cell. 11:2003;915-926.
-
(2003)
Mol. Cell
, vol.11
, pp. 915-926
-
-
Kang, Y.1
Chen, C.-R.2
Massagué, J.3
-
58
-
-
0037043739
-
A component of the ARC/Mediator complex required for TGFβ/Nodal signalling
-
Kato Y., Habas R., Katsuyama Y., Naar A.M., He X. A component of the ARC/Mediator complex required for TGFβ/Nodal signalling. Nature. 418:2002;641-646.
-
(2002)
Nature
, vol.418
, pp. 641-646
-
-
Kato, Y.1
Habas, R.2
Katsuyama, Y.3
Naar, A.M.4
He, X.5
-
59
-
-
0034517389
-
Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF-β receptor for degradation
-
Kavsak P., Rasmussen R.K., Causing C.G., Bonni S., Zhu H., Thomsen G.H., Wrana J.L. Smad7 binds to Smurf2 to form an E3 ubiquitin ligase that targets the TGF-β receptor for degradation. Mol. Cell. 6:2000;1365-1375.
-
(2000)
Mol. Cell
, vol.6
, pp. 1365-1375
-
-
Kavsak, P.1
Rasmussen, R.K.2
Causing, C.G.3
Bonni, S.4
Zhu, H.5
Thomsen, G.H.6
Wrana, J.L.7
-
60
-
-
0032528041
-
Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine/threonine kinase receptors
-
Kawabata M., Inoue H., Hanyu A., Imamura T., Miyazono K. Smad proteins exist as monomers in vivo and undergo homo- and hetero-oligomerization upon activation by serine/threonine kinase receptors. EMBO J. 17:1998;4056-4065.
-
(1998)
EMBO J.
, vol.17
, pp. 4056-4065
-
-
Kawabata, M.1
Inoue, H.2
Hanyu, A.3
Imamura, T.4
Miyazono, K.5
-
61
-
-
0030872367
-
Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic
-
Kim J., Johnson K., Chen H.J., Carroll S., Laughon A. Drosophila Mad binds to DNA and directly mediates activation of vestigial by Decapentaplegic. Nature. 388:1997;304-308.
-
(1997)
Nature
, vol.388
, pp. 304-308
-
-
Kim, J.1
Johnson, K.2
Chen, H.J.3
Carroll, S.4
Laughon, A.5
-
62
-
-
0034043106
-
Crystal structure of the BMP-2-BRIA ectodomain complex
-
Kirsch T., Sebald W., Dreyer M.K. Crystal structure of the BMP-2-BRIA ectodomain complex. Nat. Struct. Biol. 7:2000;492-496.
-
(2000)
Nat. Struct. Biol.
, vol.7
, pp. 492-496
-
-
Kirsch, T.1
Sebald, W.2
Dreyer, M.K.3
-
63
-
-
0026244229
-
Molscript: A program to produce both detailed and schematic plots of protein structures
-
Kraulis P.J. Molscript. a program to produce both detailed and schematic plots of protein structures J. Appl. Crystallogr. 24:1991;946-950.
-
(1991)
J. Appl. Crystallogr.
, vol.24
, pp. 946-950
-
-
Kraulis, P.J.1
-
64
-
-
0030911104
-
The TGF-β family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase
-
Kretzschmar M., Liu F., Hata A., Doody J., Massagué J. The TGF-β family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase. Genes Dev. 11:1997;984-995.
-
(1997)
Genes Dev.
, vol.11
, pp. 984-995
-
-
Kretzschmar, M.1
Liu, F.2
Hata, A.3
Doody, J.4
Massagué, J.5
-
65
-
-
0033106484
-
A mechanism of repression of TGF-β/Smad signaling by oncogenic Ras
-
Kretzschmar M., Doody J., Timokhina I., Massagué J. A mechanism of repression of TGF-β/Smad signaling by oncogenic Ras. Genes Dev. 13:1999;804-816.
-
(1999)
Genes Dev.
, vol.13
, pp. 804-816
-
-
Kretzschmar, M.1
Doody, J.2
Timokhina, I.3
Massagué, J.4
-
66
-
-
0035167095
-
Transforming growth factor-β induces nuclear import of Smad3 in an importin-β1 and Ran-dependent manner
-
Kurisaki A., Kose S., Yoneda Y., Heldin C.-H., Moustakas A. Transforming growth factor-β induces nuclear import of Smad3 in an importin-β1 and Ran-dependent manner. Mol. Biol. Cell. 12:2001;1079-1091.
-
(2001)
Mol. Biol. Cell
, vol.12
, pp. 1079-1091
-
-
Kurisaki, A.1
Kose, S.2
Yoneda, Y.3
Heldin, C.-H.4
Moustakas, A.5
-
67
-
-
0032110463
-
Smad2 and Smad3 positively and negatively regulate TGF-β-dependent transcription through the forkhead DNA-binding protein FAST2
-
Labbe E., Silvestri C., Hoodless P.A., Wrana J.L., Attisano L. Smad2 and Smad3 positively and negatively regulate TGF-β-dependent transcription through the forkhead DNA-binding protein FAST2. Mol. Cell. 2:1998;109-120.
-
(1998)
Mol. Cell
, vol.2
, pp. 109-120
-
-
Labbe, E.1
Silvestri, C.2
Hoodless, P.A.3
Wrana, J.L.4
Attisano, L.5
-
68
-
-
2042437650
-
Initial sequencing and analysis of the human genome
-
Lander E.S., Linton L.M., Birren B., Nusbaum C., Zody M.C., Baldwin J., Devon K., Dewar K., Doyle M., FitzHugh W.et al. Initial sequencing and analysis of the human genome. Nature. 409:2001;860-921.
-
(2001)
Nature
, vol.409
, pp. 860-921
-
-
Lander, E.S.1
Linton, L.M.2
Birren, B.3
Nusbaum, C.4
Zody, M.C.5
Baldwin, J.6
Devon, K.7
Dewar, K.8
Doyle, M.9
FitzHugh, W.10
-
69
-
-
0034704753
-
Betaglycan binds inhibin and can mediate functional antagonism of activin signalling
-
Lewis K.A., Gray P.C., Blount A.L., MacConell L.A., Wiater E., Bilezikjian L.M., Vale W. Betaglycan binds inhibin and can mediate functional antagonism of activin signalling. Nature. 404:2000;411-414.
-
(2000)
Nature
, vol.404
, pp. 411-414
-
-
Lewis, K.A.1
Gray, P.C.2
Blount, A.L.3
MacConell, L.A.4
Wiater, E.5
Bilezikjian, L.M.6
Vale, W.7
-
70
-
-
0034517812
-
Noggin antagonizes BMP signaling to create a niche for adult neurogenesis
-
Lim D.A., Tramontin A.D., Trevejo J.M., Herrera D.G., Garcia-Verdugo J.M., Alvarez-Buylla A. Noggin antagonizes BMP signaling to create a niche for adult neurogenesis. Neuron. 28:2000;713-726.
-
(2000)
Neuron
, vol.28
, pp. 713-726
-
-
Lim, D.A.1
Tramontin, A.D.2
Trevejo, J.M.3
Herrera, D.G.4
Garcia-Verdugo, J.M.5
Alvarez-Buylla, A.6
-
71
-
-
0034711290
-
Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in TGF-β signaling
-
Lin X., Liang M., Feng X.-H. Smurf2 is a ubiquitin E3 ligase mediating proteasome-dependent degradation of Smad2 in TGF-β signaling. J. Biol. Chem. 275:2000;36818-36822.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 36818-36822
-
-
Lin, X.1
Liang, M.2
Feng, X.-H.3
-
72
-
-
0030690337
-
Dual role of the Smad4/DPC4 tumor suppressor in TGF-β-inducible transcriptional complexes
-
Liu F., Pouponnot C., Massagué J. Dual role of the Smad4/DPC4 tumor suppressor in TGF-β-inducible transcriptional complexes. Genes Dev. 11:1997;3157-3167.
-
(1997)
Genes Dev.
, vol.11
, pp. 3157-3167
-
-
Liu, F.1
Pouponnot, C.2
Massagué, J.3
-
74
-
-
0033257926
-
Ubiquitin-dependent degradation of TGF-β-activated Smad2
-
Lo R.S., Massagué J. Ubiquitin-dependent degradation of TGF-β-activated Smad2. Nat. Cell Biol. 1:1999;472-478.
-
(1999)
Nat. Cell Biol.
, vol.1
, pp. 472-478
-
-
Lo, R.S.1
Massagué, J.2
-
75
-
-
0032481351
-
The L3 loop: A structural motif determining specific interactions between SMAD proteins and TGF-β receptors
-
Lo R.S., Chen Y.-G., Shi Y., Pavletich N.P., Massagué J. The L3 loop. a structural motif determining specific interactions between SMAD proteins and TGF-β receptors EMBO J. 17:1998;996-1005.
-
(1998)
EMBO J.
, vol.17
, pp. 996-1005
-
-
Lo, R.S.1
Chen, Y.-G.2
Shi, Y.3
Pavletich, N.P.4
Massagué, J.5
-
76
-
-
0035863208
-
Epidermal growth factor signaling via Ras controls the Smad transcriptional co-repressor TGIF
-
Lo R.S., Wotton D., Massagué J. Epidermal growth factor signaling via Ras controls the Smad transcriptional co-repressor TGIF. EMBO J. 20:2001;128-136.
-
(2001)
EMBO J.
, vol.20
, pp. 128-136
-
-
Lo, R.S.1
Wotton, D.2
Massagué, J.3
-
77
-
-
0037119489
-
Transforming growth factor β activates Smad2 in the absence of receptor endocytosis
-
Lu Z., Murray J.T., Luo W., Li H., Wu X., Xu H., Backer J.M., Chen Y.G. Transforming growth factor β activates Smad2 in the absence of receptor endocytosis. J. Biol. Chem. 277:2002;29363-29368.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 29363-29368
-
-
Lu, Z.1
Murray, J.T.2
Luo, W.3
Li, H.4
Wu, X.5
Xu, H.6
Backer, J.M.7
Chen, Y.G.8
-
78
-
-
0033200361
-
The Ski oncoprotein interacts with the Smad proteins to repress TGF-β signaling
-
Luo K., Stroschein S.L., Wang W., Chen D., Martens E., Zhou S., Zhou Q. The Ski oncoprotein interacts with the Smad proteins to repress TGF-β signaling. Genes Dev. 13:1999;2196-2206.
-
(1999)
Genes Dev.
, vol.13
, pp. 2196-2206
-
-
Luo, K.1
Stroschein, S.L.2
Wang, W.3
Chen, D.4
Martens, E.5
Zhou, S.6
Zhou, Q.7
-
79
-
-
0030300115
-
MADR2 is a substrate of the TGF-β receptor and its phosphorylation is required for nuclear accumulation and signalling
-
Macias-Silva M., Abdollah S., Hoodless P.A., Pirone R., Attisano L., Wrana J.L. MADR2 is a substrate of the TGF-β receptor and its phosphorylation is required for nuclear accumulation and signalling. Cell. 87:1996;1215-1224.
-
(1996)
Cell
, vol.87
, pp. 1215-1224
-
-
Macias-Silva, M.1
Abdollah, S.2
Hoodless, P.A.3
Pirone, R.4
Attisano, L.5
Wrana, J.L.6
-
80
-
-
0037032835
-
The protein kinase complement of the human genome
-
Manning G., Whyte D.B., Martinez R., Hunter T., Sudarsanam S. The protein kinase complement of the human genome. Science. 298:2002;1912-1934.
-
(2002)
Science
, vol.298
, pp. 1912-1934
-
-
Manning, G.1
Whyte, D.B.2
Martinez, R.3
Hunter, T.4
Sudarsanam, S.5
-
81
-
-
0031695806
-
Genetic abnormalities in hereditary hemorrhagic telangiectasia
-
Marchuk D.A. Genetic abnormalities in hereditary hemorrhagic telangiectasia. Curr. Opin. Hematol. 5:1998;332-338.
-
(1998)
Curr. Opin. Hematol.
, vol.5
, pp. 332-338
-
-
Marchuk, D.A.1
-
82
-
-
0037470580
-
Solution structure of the chick TGF-β type II receptor ligand-binding domain
-
Marlow M.S., Brown C.B., Barnett J.V., Krezel A.M. Solution structure of the chick TGF-β type II receptor ligand-binding domain. J. Mol. Biol. 326:2003;989-997.
-
(2003)
J. Mol. Biol.
, vol.326
, pp. 989-997
-
-
Marlow, M.S.1
Brown, C.B.2
Barnett, J.V.3
Krezel, A.M.4
-
83
-
-
0031685620
-
TGF-β signal transduction
-
Massagué J. TGF-β signal transduction. Annu. Rev. Biochem. 67:1998;753-791.
-
(1998)
Annu. Rev. Biochem.
, vol.67
, pp. 753-791
-
-
Massagué, J.1
-
84
-
-
0034574298
-
How cells read TGF-β signals
-
Massagué J. How cells read TGF-β signals. Nat. Rev. Mol. Cell Biol. 1:2000;169-178.
-
(2000)
Nat. Rev. Mol. Cell Biol.
, vol.1
, pp. 169-178
-
-
Massagué, J.1
-
85
-
-
0034654497
-
Controlling TGF-β signaling
-
Massagué J., Chen Y.-G. Controlling TGF-β signaling. Genes Dev. 14:2000;627-644.
-
(2000)
Genes Dev.
, vol.14
, pp. 627-644
-
-
Massagué, J.1
Chen, Y.-G.2
-
86
-
-
0034678908
-
Transcriptional control by the TGF-β/Smad signaling system
-
Massagué J., Wotton D. Transcriptional control by the TGF-β/Smad signaling system. EMBO J. 19:2000;1745-1754.
-
(2000)
EMBO J.
, vol.19
, pp. 1745-1754
-
-
Massagué, J.1
Wotton, D.2
-
87
-
-
0034644472
-
TGF-β Signaling in growth control, cancer, and heritable disorders
-
Massagué J., Blain S.W., Lo R.S. TGF-β Signaling in growth control, cancer, and heritable disorders. Cell. 103:2000;295-309.
-
(2000)
Cell
, vol.103
, pp. 295-309
-
-
Massagué, J.1
Blain, S.W.2
Lo, R.S.3
-
88
-
-
0031707505
-
Nucleocytoplasmic transport: The soluble phase
-
Mattaj I.W., Englmeier L. Nucleocytoplasmic transport. the soluble phase Annu. Rev. Biochem. 67:1998;265-306.
-
(1998)
Annu. Rev. Biochem.
, vol.67
, pp. 265-306
-
-
Mattaj, I.W.1
Englmeier, L.2
-
89
-
-
0034462833
-
Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA
-
Mirura S., Takeshita T., Asao H., Kimura Y., Murata K., Sasaki Y., Hanai J.I., Beppu H., Tsukazaki T., Wrana J.L.et al. Hgs (Hrs), a FYVE domain protein, is involved in Smad signaling through cooperation with SARA. Mol. Cell. Biol. 20:2000;9346-9355.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 9346-9355
-
-
Mirura, S.1
Takeshita, T.2
Asao, H.3
Kimura, Y.4
Murata, K.5
Sasaki, Y.6
Hanai, J.I.7
Beppu, H.8
Tsukazaki, T.9
Wrana, J.L.10
-
90
-
-
0029943464
-
The crystal structure of TGF-beta 3 and comparison to TGF-β2: Implications for receptor binding
-
Mittl P.R., Priestle J.P., Cox D.A., McMaster G., Cerletti N., Grutter M.G. The crystal structure of TGF-beta 3 and comparison to TGF-β2. implications for receptor binding Protein Sci. 5:1996;1261-1271.
-
(1996)
Protein Sci.
, vol.5
, pp. 1261-1271
-
-
Mittl, P.R.1
Priestle, J.P.2
Cox, D.A.3
McMaster, G.4
Cerletti, N.5
Grutter, M.G.6
-
91
-
-
0036735752
-
Functional heterogeneity of bone morphogenetic protein receptor-II mutants found in patients with primary pulmonary hypertension
-
Nishihara A., Watabe T., Imamura T., Miyazono K. Functional heterogeneity of bone morphogenetic protein receptor-II mutants found in patients with primary pulmonary hypertension. Mol. Biol. Cell. 13:2002;3055-3063.
-
(2002)
Mol. Biol. Cell
, vol.13
, pp. 3055-3063
-
-
Nishihara, A.1
Watabe, T.2
Imamura, T.3
Miyazono, K.4
-
92
-
-
0033619255
-
Silencing of TGF-β signalling by the pseudoreceptor BAMBI
-
Onichtchouk D., Chen Y.G., Dosch R., Gawantka V., Delius H., Massagué J., Niehrs C. Silencing of TGF-β signalling by the pseudoreceptor BAMBI. Nature. 401:1999;480-485.
-
(1999)
Nature
, vol.401
, pp. 480-485
-
-
Onichtchouk, D.1
Chen, Y.G.2
Dosch, R.3
Gawantka, V.4
Delius, H.5
Massagué, J.6
Niehrs, C.7
-
93
-
-
0033985464
-
TGF-β-related pathways. Roles in Caenorhabditis elegans development
-
Patterson G.I., Padgett R.W. TGF-β-related pathways. Roles in Caenorhabditis elegans development. Trends Genet. 16:2000;27-33.
-
(2000)
Trends Genet.
, vol.16
, pp. 27-33
-
-
Patterson, G.I.1
Padgett, R.W.2
-
94
-
-
0034671578
-
TGF-β inhibits p70 S6 kinase via protein phosphatase 2A to induce G1 arrest
-
Petritsch C., Beug H., Balmain A., Oft M. TGF-β inhibits p70 S6 kinase via protein phosphatase 2A to induce G1 arrest. Genes Dev. 14:2000;3093-3101.
-
(2000)
Genes Dev.
, vol.14
, pp. 3093-3101
-
-
Petritsch, C.1
Beug, H.2
Balmain, A.3
Oft, M.4
-
95
-
-
0034460336
-
Transforming growth factor β-independent shuttling of Smad4 between the cytoplasm and nucleus
-
Pierreux C.E., Nicolas F.J., Hill C.S. Transforming growth factor β-independent shuttling of Smad4 between the cytoplasm and nucleus. Mol. Biol. Cell. 20:2000;9041-9054.
-
(2000)
Mol. Biol. Cell
, vol.20
, pp. 9041-9054
-
-
Pierreux, C.E.1
Nicolas, F.J.2
Hill, C.S.3
-
96
-
-
0035695116
-
Structural basis of Smad1 activation by receptor kinase phosphorylation
-
Qin B.Y., Chacko B.M., Lam S.S., de Caestecker M.P., Correia J.J., Lin K. Structural basis of Smad1 activation by receptor kinase phosphorylation. Mol. Cell. 8:2001;1303-1312.
-
(2001)
Mol. Cell
, vol.8
, pp. 1303-1312
-
-
Qin, B.Y.1
Chacko, B.M.2
Lam, S.S.3
De Caestecker, M.P.4
Correia, J.J.5
Lin, K.6
-
97
-
-
0037080983
-
Different Smad2 partners bind a common hydrophobic pocket in Smad2 via a defined proline-rich motif
-
Randall R.A., Germain S., Inman G.S., Bates P.A., Hill C.S. Different Smad2 partners bind a common hydrophobic pocket in Smad2 via a defined proline-rich motif. EMBO J. 21:2002;145-156.
-
(2002)
EMBO J.
, vol.21
, pp. 145-156
-
-
Randall, R.A.1
Germain, S.2
Inman, G.S.3
Bates, P.A.4
Hill, C.S.5
-
98
-
-
0037069204
-
-
Rosa, F.M. (2002). Cripto, a multifunctional partner in signaling: molecular forms and activities. Sci. STKE (158), pe47
-
Rosa, F.M. (2002). Cripto, a multifunctional partner in signaling: molecular forms and activities. Sci. STKE (158), pe47.
-
-
-
-
99
-
-
0035800838
-
Oncogenic ras represses transforming growth factor-β/Smad signaling by degrading tumor suppressor Smad4
-
Saha D., Datta P.K., Beauchamp R.D. Oncogenic ras represses transforming growth factor-β/Smad signaling by degrading tumor suppressor Smad4. J. Biol. Chem. 276:2001;29531-29537.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 29531-29537
-
-
Saha, D.1
Datta, P.K.2
Beauchamp, R.D.3
-
100
-
-
0028940853
-
Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster
-
Sekelsky J.J., Newfeld S.J., Raftery L.A., Chartoff E.H., Gelbart W.M. Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster. Genetics. 139:1995;1347-1358.
-
(1995)
Genetics
, vol.139
, pp. 1347-1358
-
-
Sekelsky, J.J.1
Newfeld, S.J.2
Raftery, L.A.3
Chartoff, E.H.4
Gelbart, W.M.5
-
101
-
-
0034744956
-
TGF-β influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b
-
Seoane J., Pouponnot C., Staller P., Schader M., Eilers M., Massagué J. TGF-β influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b. Nat. Cell Biol. 3:2001;400-408.
-
(2001)
Nat. Cell Biol.
, vol.3
, pp. 400-408
-
-
Seoane, J.1
Pouponnot, C.2
Staller, P.3
Schader, M.4
Eilers, M.5
Massagué, J.6
-
102
-
-
0034237708
-
The EGF-CFC gene family in vertebrate development
-
Shen M.M., Schier A.F. The EGF-CFC gene family in vertebrate development. Trends Genet. 16:2000;303-309.
-
(2000)
Trends Genet.
, vol.16
, pp. 303-309
-
-
Shen, M.M.1
Schier, A.F.2
-
103
-
-
0035116044
-
Structural insights on Smad function in TGF-β signaling
-
Shi Y. Structural insights on Smad function in TGF-β signaling. Bioessays. 23:2001;223-232.
-
(2001)
Bioessays
, vol.23
, pp. 223-232
-
-
Shi, Y.1
-
104
-
-
0032483544
-
Crystal structure of a Smad MH1 domain bound to DNA: Insights on DNA binding in TGF-β signaling
-
Shi Y., Wang Y.-F., Jayaraman L., Yang H., Massagué J., Pavletich N.P. Crystal structure of a Smad MH1 domain bound to DNA. insights on DNA binding in TGF-β signaling Cell. 94:1998;585-594.
-
(1998)
Cell
, vol.94
, pp. 585-594
-
-
Shi, Y.1
Wang, Y.-F.2
Jayaraman, L.3
Yang, H.4
Massagué, J.5
Pavletich, N.P.6
-
105
-
-
0030613262
-
Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling
-
Souchelnytskyi S., Tamaki K., Engstrom U., Wernstedt C., ten Dijke P., Heldin C.H. Phosphorylation of Ser465 and Ser467 in the C terminus of Smad2 mediates interaction with Smad4 and is required for transforming growth factor-beta signaling. J. Biol. Chem. 272:1997;28107-28115.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 28107-28115
-
-
Souchelnytskyi, S.1
Tamaki, K.2
Engstrom, U.3
Wernstedt, C.4
Ten Dijke, P.5
Heldin, C.H.6
-
106
-
-
0034744957
-
Repression of p15INK4b expression by Myc through association with Miz-1
-
Staller P., Peukert K., Kiermaier A., Seoane J., Lukas J., Karsunky H., Moroy T., Bartek J., Massagué J., Hanel F., Eilers M. Repression of p15INK4b expression by Myc through association with Miz-1. Nat. Cell Biol. 3:2001;392-399.
-
(2001)
Nat. Cell Biol.
, vol.3
, pp. 392-399
-
-
Staller, P.1
Peukert, K.2
Kiermaier, A.3
Seoane, J.4
Lukas, J.5
Karsunky, H.6
Moroy, T.7
Bartek, J.8
Massagué, J.9
Hanel, F.10
Eilers, M.11
-
107
-
-
0033595704
-
Negative feedback regulation of TGF-β signaling by the SnoN oncoprotein
-
Stroschein S.L., Wang W., Zhou S., Zhou Q., Luo K. Negative feedback regulation of TGF-β signaling by the SnoN oncoprotein. Science. 286:1999;771-774.
-
(1999)
Science
, vol.286
, pp. 771-774
-
-
Stroschein, S.L.1
Wang, W.2
Zhou, S.3
Zhou, Q.4
Luo, K.5
-
108
-
-
0035498980
-
Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN
-
Stroschein S.L., Bonni S., Wrana J.L., Luo K. Smad3 recruits the anaphase-promoting complex for ubiquitination and degradation of SnoN. Genes Dev. 15:2001;2822-2836.
-
(2001)
Genes Dev.
, vol.15
, pp. 2822-2836
-
-
Stroschein, S.L.1
Bonni, S.2
Wrana, J.L.3
Luo, K.4
-
110
-
-
0037131283
-
Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane
-
Suzuki C., Murakami G., Fukuchi M., Shimanuki T., Shikauchi Y., Imamura T., Miyazono K. Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane. J. Biol. Chem. 277:2002;39919-39925.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 39919-39925
-
-
Suzuki, C.1
Murakami, G.2
Fukuchi, M.3
Shimanuki, T.4
Shikauchi, Y.5
Imamura, T.6
Miyazono, K.7
-
111
-
-
0038363366
-
Chromosomal region maitenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-β signaling by Smad7
-
Tajima Y., Goto K., Yoshida M., Shinomiya K., Sekimoto T., Yoneda Y., Miyazono K., Imamura T. Chromosomal region maitenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-β signaling by Smad7. J. Biol. Chem. 278:2003;10716-10721.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 10716-10721
-
-
Tajima, Y.1
Goto, K.2
Yoshida, M.3
Shinomiya, K.4
Sekimoto, T.5
Yoneda, Y.6
Miyazono, K.7
Imamura, T.8
-
112
-
-
0037462502
-
Disruption of transforming growth factor-β signaling in ELF β-spectrin-deficient mice
-
Tang Y., Katuri V., Dillner A., Mishra B., Deng C.X., Mishra L. Disruption of transforming growth factor-β signaling in ELF β-spectrin-deficient mice. Science. 299:2003;574-577.
-
(2003)
Science
, vol.299
, pp. 574-577
-
-
Tang, Y.1
Katuri, V.2
Dillner, A.3
Mishra, B.4
Deng, C.X.5
Mishra, L.6
-
113
-
-
0033956131
-
Signaling inputs converge on nuclear effectors in TGF-β signaling
-
ten Dijke P., Miyazono K., Heldin C.-H. Signaling inputs converge on nuclear effectors in TGF-β signaling. Trends Biochem. Sci. 25:2000;64-70.
-
(2000)
Trends Biochem. Sci.
, vol.25
, pp. 64-70
-
-
Ten Dijke, P.1
Miyazono, K.2
Heldin, C.-H.3
-
115
-
-
0345269804
-
Structures of an ActRIIB:activin A complex reveal a novel binding mode for TGF-β ligand:receptor interactions
-
Thompson T.B., Woodruff T.K., Jardetzky T.S. Structures of an ActRIIB:activin A complex reveal a novel binding mode for TGF-β ligand:receptor interactions. EMBO J. 22:2003;1555-1566.
-
(2003)
EMBO J.
, vol.22
, pp. 1555-1566
-
-
Thompson, T.B.1
Woodruff, T.K.2
Jardetzky, T.S.3
-
116
-
-
0032428684
-
SARA, a FYVE Domain Protein that Recruits Smad2 to the TGF-β Receptor
-
Tsukazaki T., Chiang T.A., Davison A.F., Attisano L., Wrana J.L. SARA, a FYVE Domain Protein that Recruits Smad2 to the TGF-β Receptor. Cell. 95:1998;779-791.
-
(1998)
Cell
, vol.95
, pp. 779-791
-
-
Tsukazaki, T.1
Chiang, T.A.2
Davison, A.F.3
Attisano, L.4
Wrana, J.L.5
-
117
-
-
0033602101
-
Inhibition of transforming growth factor-β/SMAD signalling by the interferon-gamma/STAT pathway
-
Ulloa L., Doody J., Massagué J. Inhibition of transforming growth factor-β/SMAD signalling by the interferon-gamma/STAT pathway. Nature. 297:1999;710-713.
-
(1999)
Nature
, vol.297
, pp. 710-713
-
-
Ulloa, L.1
Doody, J.2
Massagué, J.3
-
118
-
-
0035930333
-
The anaphase-promoting complex mediates TGF-β signaling by targeting SnoN for destruction
-
Wan Y., Liu X., Kirschner M.W. The anaphase-promoting complex mediates TGF-β signaling by targeting SnoN for destruction. Mol. Cell. 8:2001;1027-1039.
-
(2001)
Mol. Cell
, vol.8
, pp. 1027-1039
-
-
Wan, Y.1
Liu, X.2
Kirschner, M.W.3
-
119
-
-
0034687731
-
Ski represses bone morphogenetic protein signaling in Xenopus and mammalian cells
-
Wang W., Mariani F.V., Harland R.M., Luo K. Ski represses bone morphogenetic protein signaling in Xenopus and mammalian cells. Proc. Natl. Acad. Sci. USA. 97:2000;14394-14399.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 14394-14399
-
-
Wang, W.1
Mariani, F.V.2
Harland, R.M.3
Luo, K.4
-
120
-
-
0034252221
-
Regulation of intracellular dynamics of Smad4 by its leucine-rich nuclear export signal
-
Watanabe M., Masuyama N., Fukuda M., Nishida E. Regulation of intracellular dynamics of Smad4 by its leucine-rich nuclear export signal. EMBO Rep. 1:2000;176-182.
-
(2000)
EMBO Rep.
, vol.1
, pp. 176-182
-
-
Watanabe, M.1
Masuyama, N.2
Fukuda, M.3
Nishida, E.4
-
121
-
-
0033780420
-
Inactivation of smad-transforming growth factor beta signaling by Ca(2+)-calmodulin-dependent protein kinase II
-
Wicks S.J., Lui S., Abdel-Wahab N., Mason R.M., Chantry A. Inactivation of smad-transforming growth factor beta signaling by Ca(2+)-calmodulin-dependent protein kinase II. Mol. Cell. Biol. 20:2000;8103-8111.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 8103-8111
-
-
Wicks, S.J.1
Lui, S.2
Abdel-Wahab, N.3
Mason, R.M.4
Chantry, A.5
-
122
-
-
0033515620
-
A Smad transcriptional corepressor
-
a
-
Wotton D., Lo R.S., Lee S., Massagué J. A Smad transcriptional corepressor. Cell. 97:1999;29-39. a.
-
(1999)
Cell
, vol.97
, pp. 29-39
-
-
Wotton, D.1
Lo, R.S.2
Lee, S.3
Massagué, J.4
-
123
-
-
0033601272
-
Multiple modes of repression by the Smad transcriptional corepressor TGIF
-
b
-
Wotton D., Lo R.S., Swaby L.A., Massagué J. Multiple modes of repression by the Smad transcriptional corepressor TGIF. J. Biol. Chem. 274:1999;37105-37110. b.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 37105-37110
-
-
Wotton, D.1
Lo, R.S.2
Swaby, L.A.3
Massagué, J.4
-
124
-
-
0034800012
-
The Smad transcriptional corepressor TGIF recruits mSin3
-
Wotton D., Knoepfler P.S., Laherty C.D., Eisenman R.N., Massagué J. The Smad transcriptional corepressor TGIF recruits mSin3. Cell Growth Differ. 12:2001;457-463.
-
(2001)
Cell Growth Differ.
, vol.12
, pp. 457-463
-
-
Wotton, D.1
Knoepfler, P.S.2
Laherty, C.D.3
Eisenman, R.N.4
Massagué, J.5
-
125
-
-
0034614708
-
Structural basis of Smad2 recognition by the Smad anchor for receptor activation
-
Wu G., Chen Y.-G., Ozdamar B., Gyuricza C.A., Chong P.A., Wrana J.L., Massagué J., Shi Y. Structural basis of Smad2 recognition by the Smad anchor for receptor activation. Science. 287:2000;92-97.
-
(2000)
Science
, vol.287
, pp. 92-97
-
-
Wu, G.1
Chen, Y.-G.2
Ozdamar, B.3
Gyuricza, C.A.4
Chong, P.A.5
Wrana, J.L.6
Massagué, J.7
Shi, Y.8
-
126
-
-
0035827668
-
Formation of a stable heterodimer between Smad2 and Smad4
-
a
-
Wu J.-W., Fairman R., Penry J., Shi Y. Formation of a stable heterodimer between Smad2 and Smad4. J. Biol. Chem. 276:2001;20688-20694. a.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 20688-20694
-
-
Wu, J.-W.1
Fairman, R.2
Penry, J.3
Shi, Y.4
-
127
-
-
18244362844
-
Crystal structure of a phosphorylated Smad2: Recognition of phosphoserine by the MH2 domain and insights on Smad function in TGF-β signaling
-
b
-
Wu J.-W., Hu M., Chai J., Seoane J., Huse M., Li C., Rigotti D.J., Kyin S., Muir T.W., Fairman R.et al. Crystal structure of a phosphorylated Smad2. recognition of phosphoserine by the MH2 domain and insights on Smad function in TGF-β signaling Mol. Cell. 8:2001;1277-1289. b.
-
(2001)
Mol. Cell
, vol.8
, pp. 1277-1289
-
-
Wu, J.-W.1
Hu, M.2
Chai, J.3
Seoane, J.4
Huse, M.5
Li, C.6
Rigotti, D.J.7
Kyin, S.8
Muir, T.W.9
Fairman, R.10
-
128
-
-
0036848069
-
Structural mechanism of Smad4 recognition by the nuclear oncoprotein Ski: Insights on Ski-mediated repression of TGF-β signaling
-
Wu J.-W., Krawitz A.R., Chai J., Li W., Zhang F., Luo K., Shi Y. Structural mechanism of Smad4 recognition by the nuclear oncoprotein Ski. insights on Ski-mediated repression of TGF-β signaling Cell. 111:2002;357-367.
-
(2002)
Cell
, vol.111
, pp. 357-367
-
-
Wu, J.-W.1
Krawitz, A.R.2
Chai, J.3
Li, W.4
Zhang, F.5
Luo, K.6
Shi, Y.7
-
129
-
-
0034608799
-
A distinct nuclear localization signal in the N terminus of Smad3 determines its ligand-induced nuclear translocation
-
a
-
Xiao Z., Liu X., Henis Y.I., Lodish H.F. A distinct nuclear localization signal in the N terminus of Smad3 determines its ligand-induced nuclear translocation. Proc. Natl. Acad. Sci. USA. 97:2000;7853-7858. a.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 7853-7858
-
-
Xiao, Z.1
Liu, X.2
Henis, Y.I.3
Lodish, H.F.4
-
130
-
-
0034604343
-
Importin β mediates nuclear translocation of Smad3
-
b
-
Xiao Z., Liu X., Lodish H.F. Importin β mediates nuclear translocation of Smad3. J. Biol. Chem. 275:2000;23425-23428. b.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 23425-23428
-
-
Xiao, Z.1
Liu, X.2
Lodish, H.F.3
-
131
-
-
0347664883
-
Nucleocytoplasmic shuttling of Smad1 conferred by its nuclear localization and nuclear export signal
-
Xiao Z., Watson N., Rodriguez C., Lodish H.F. Nucleocytoplasmic shuttling of Smad1 conferred by its nuclear localization and nuclear export signal. J. Biol. Chem. 276:2001;39404-39410.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 39404-39410
-
-
Xiao, Z.1
Watson, N.2
Rodriguez, C.3
Lodish, H.F.4
-
132
-
-
0037455715
-
An extended bipartite nuclear localization signal in Smad4 is required for its nuclear import and transcriptional activity
-
Xiao Z., Latek R., Lodish H.F. An extended bipartite nuclear localization signal in Smad4 is required for its nuclear import and transcriptional activity. Oncogene. 22:2003;1057-1069.
-
(2003)
Oncogene
, vol.22
, pp. 1057-1069
-
-
Xiao, Z.1
Latek, R.2
Lodish, H.F.3
-
133
-
-
0034253480
-
Smad2 nuclear import function masked by SARA and unmasked by TGFβ-dependent phosphorylation
-
Xu L., Chen Y.-G., Massagué J. Smad2 nuclear import function masked by SARA and unmasked by TGFβ-dependent phosphorylation. Nat. Cell Biol. 2:2000;559-562.
-
(2000)
Nat. Cell Biol.
, vol.2
, pp. 559-562
-
-
Xu, L.1
Chen, Y.-G.2
Massagué, J.3
-
134
-
-
0036670359
-
Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGF-β signaling complexes in the cytoplasm and nucleus
-
Xu L., Kang Y., Col S., Massagué J. Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGF-β signaling complexes in the cytoplasm and nucleus. Mol. Cell. 10:2002;271-282.
-
(2002)
Mol. Cell
, vol.10
, pp. 271-282
-
-
Xu, L.1
Kang, Y.2
Col, S.3
Massagué, J.4
-
135
-
-
0033534573
-
Alternatively spliced variant of Smad2 lacking exon 3
-
Yagi K., Goto D., Hamamoto T., Takenoshita S., Kato M., Miyazono K. Alternatively spliced variant of Smad2 lacking exon 3. J. Biol. Chem. 274:1999;703-709.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 703-709
-
-
Yagi, K.1
Goto, D.2
Hamamoto, T.3
Takenoshita, S.4
Kato, M.5
Miyazono, K.6
-
136
-
-
0030697971
-
Tumor suppressor Smad4 is a transforming growth factor β-inducible DNA binding protein
-
Yingling J.M., Datto M.B., Wong C., Frederick J.P., Liberati N.T., Wang X.-F. Tumor suppressor Smad4 is a transforming growth factor β-inducible DNA binding protein. Mol. Cell. Biol. 17:1997;7019-7028.
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 7019-7028
-
-
Yingling, J.M.1
Datto, M.B.2
Wong, C.3
Frederick, J.P.4
Liberati, N.T.5
Wang, X.-F.6
-
137
-
-
0037099745
-
TGF-β receptor-activated p38 MAP kinase mediates Smad-independent TGF-β responses
-
Yu L., Hebert M.C., Zhang Y.E. TGF-β receptor-activated p38 MAP kinase mediates Smad-independent TGF-β responses. EMBO J. 21:2002;3749-3759.
-
(2002)
EMBO J.
, vol.21
, pp. 3749-3759
-
-
Yu, L.1
Hebert, M.C.2
Zhang, Y.E.3
-
138
-
-
0032014216
-
Human Smad3 and Smad4 are sequence-specific transcription activators
-
Zawel L., Dai J.L., Buckhaults P., Zhou S., Kinzler K.W., Vogelstein B., Kern S.E. Human Smad3 and Smad4 are sequence-specific transcription activators. Mol. Cell. 1:1998;611-617.
-
(1998)
Mol. Cell
, vol.1
, pp. 611-617
-
-
Zawel, L.1
Dai, J.L.2
Buckhaults, P.3
Zhou, S.4
Kinzler, K.W.5
Vogelstein, B.6
Kern, S.E.7
-
139
-
-
0035970096
-
Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase
-
Zhang Y., Chang C., Gehling D.J., Hemmati-Brivanlou A., Derynck R. Regulation of Smad degradation and activity by Smurf2, an E3 ubiquitin ligase. Proc. Natl. Acad. Sci. USA. 98:2001;974-979.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 974-979
-
-
Zhang, Y.1
Chang, C.2
Gehling, D.J.3
Hemmati-Brivanlou, A.4
Derynck, R.5
-
140
-
-
0033549789
-
A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation
-
Zhu H., Kavsak P., Abdollah S., Wrana J.L., Thomsen G.H. A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation. Nature. 400:1999;687-693.
-
(1999)
Nature
, vol.400
, pp. 687-693
-
-
Zhu, H.1
Kavsak, P.2
Abdollah, S.3
Wrana, J.L.4
Thomsen, G.H.5
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