Post-transcriptional gene regulation by MAP kinases via AU-rich elements

Frontiers in Bioscience

Volumn 14, Issue 3, 2009, Pages 847-871

  Clark, Andrew ^a   Dean, Jonathan ^a   Tudor, Corina ^a   Saklatvala, Jeremy ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Adenylate uridylate rich element; Auf; Cytokine production; ERK; HuR; Inflammation; JNK; KSRP; Mitogen activated protein kinase; MRNA stability; MRNA translation; P38 MAPK; Posttranscriptional regulation; Processing body; Protein phosphorylation; Review; Tristetraprolin

Indexed keywords

EUKARYOTA;

ANIMAL; CELL LINE; HUMAN; MOUSE; REVIEW; RNA PROCESSING; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINE; HUMANS; MAP KINASE SIGNALING SYSTEM; MICE; RNA PROCESSING, POST-TRANSCRIPTIONAL;

EID: 63849239758     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/3282     Document Type: Article

References (264)

1. Yang, E., E. van Nimwegen, M. Zavolan, N. Rajewsky, M. Schroeder, M. Magnasco & J. E. Darnell, Jr.: Decay rates of human mRNAs: correlation with functional characteristics and sequence attributes. Genome Res, 13, 1863-72 (2003). (Pubitemid 36987192)
2. Garneau, N. L., J. Wilusz & C. J. Wilusz: The highways and byways of mRNA decay. Nat Rev Mol Cell Biol, 8, 113-26 (2007). (Pubitemid 46432531)
3. Bevilacqua, A., M. C. Ceriani, S. Capaccioli & A. Nicolin: Post-transcriptional regulation of gene expression by degradation of messenger RNAs. Journal of Cellular Physiology, 195, 356-72 (2003). (Pubitemid 36529864)
4. Stoecklin, G., T. Mayo & P. Anderson: ARE-mRNA degradation requires the 5′-3′ decay pathway. EMBO Rep, 7, 72-7 (2006).
5. Kedersha, N. & P. Anderson: Mammalian stress granules and processing bodies. Methods in Enzymology, 431, 61-81 (2007).
6. Eulalio, A., I. Behm-Ansmant & E. Izaurralde: P bodies: at the crossroads of post-transcriptional pathways. Nat Rev Mol Cell Biol, 8, 9-22 (2007). (Pubitemid 46012011)
7. Parker, R. & U. Sheth: P bodies and the control of mRNA translation and degradation. Molecular Cell, 25, 635-46 (2007). (Pubitemid 46341926)
8. Shaw, G. & R. Kamen: A conserved AU sequence from the 3′ untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell, 46, 659-67 (1986).
9. Caput, D., B. Beutler, K. Hartog, R. Thayer, S. Brown-Shimer & A. Cerami: Identification of a common nucleotide sequence in the 3′-untranslated region of mRNA molecules specifying inflammatory mediators. Proceedings of the National Academy of Sciences of the United States of America, 83, 1670-4 (1986). (Pubitemid 16018626)
10. Halees, A. S., R. El-Badrawi & K. S. Khabar: ARED Organism: expansion of ARED reveals AU-rich element cluster variations between human and mouse. Nucleic Acids Research, 36, D137-40 (2008). (Pubitemid 351149710)
11. Lagnado, C. A., C. Y. Brown & G. J. Goodall: AUUUA is not sufficient to promote poly (A) shortening and degradation of an mRNA: the functional sequence within AU-rich elements may be UUAUUUA (U/A) (U/A). Molecular & Cellular Biology, 14, 7984-95 (1994). (Pubitemid 24373547)
12. Zubiaga, A. M., J. G. Belasco & M. E. Greenberg: The nonamer UUAUUUAUU is the key AU-rich sequence motif that mediates mRNA degradation. Molecular & Cellular Biology, 15, 2219-30 (1995).
13. Gherzi, R., K. Y. Lee, P. Briata, D. Wegmuller, C. Moroni, M. Karin & C. Y. Chen: A KH domain RNA binding protein, KSRP, promotes ARE-directed mRNA turnover by recruiting the degradation machinery. Molecular Cell, 14, 571-83 (2004). (Pubitemid 38739081)
14. Fenger-Gron, M., C. Fillman, B. Norrild & J. Lykke-Andersen: Multiple processing body factors and the ARE binding protein TTP activate mRNA decapping. Molecular Cell, 20, 905-15 (2005). (Pubitemid 41814879)
15. Lykke-Andersen, J. & E. Wagner: Recruitment and activation of mRNA decay enzymes by two ARE-mediated decay activation domains in the proteins TTP and BRF-1. Genes & Development, 19, 351-61 (2005). (Pubitemid 40189298)
16. Chou, C. F., A. Mulky, S. Maitra, W. J. Lin, R. Gherzi, J. Kappes & C. Y. Chen: Tethering KSRP, a decay-promoting AU-rich element-binding protein, to mRNAs elicits mRNA decay. Molecular & Cellular Biology, 26, 3695-706 (2006). (Pubitemid 43726388)
17. Franks, T. M. & J. Lykke-Andersen: TTP and BRF proteins nucleate processing body formation to silence mRNAs with AU-rich elements. Genes & Development, 21, 719-35 (2007). (Pubitemid 46440293)
18. Chen, C. Y., R. Gherzi, S. E. Ong, E. L. Chan, R. Raijmakers, G. J. Pruijn, G. Stoecklin, C. Moroni, M. Mann & M. Karin: AU binding proteins recruit the exosome to degrade ARE-containing mRNAs. Cell, 107, 451-64. (2001). (Pubitemid 33152781)
19. Mukherjee, D., M. Gao, J. P. O'Connor, R. Raijmakers, G. Pruijn, C. S. Lutz & J. Wilusz: The mammalian exosome mediates the efficient degradation of mRNAs that contain AU-rich elements. EMBO Journal, 21, 165-74. (2002). (Pubitemid 34087085)
20. Hau, H. H., R. J. Walsh, R. L. Ogilvie, D. A. Williams, C. S. Reilly & P. R. Bohjanen: Tristetraprolin recruits functional mRNA decay complexes to ARE sequences. J Cell Biochem (2006).
21. Wilson, G. M., K. Sutphen, K. Chuang & G. Brewer: Folding of A+U-rich RNA Elements Modulates AUF1 Binding. POTENTIAL ROLES IN REGULATION OF mRNA TURNOVER. Journal of Biological Chemistry, 276, 8695-704. (2001).
22. Meisner, N. C., J. Hackermuller, V. Uhl, A. Aszodi, M. Jaritz & M. Auer: mRNA openers and closers: modulating AU-rich element-controlled mRNA stability by a molecular switch in mRNA secondary structure. Chembiochem, 5, 1432-47 (2004). (Pubitemid 39371510)
23. Raghavan, A. & P. R. Bohjanen: Microarray-based analyses of mRNA decay in the regulation of mammalian gene expression. Brief Funct Genomic Proteomic, 3, 112- 24 (2004).
24. Cheadle, C., J. Fan, Y. S. Cho-Chung, T. Werner, J. Ray, L. Do, M. Gorospe & K. G. Becker: Stability regulation of mRNA and the control of gene expression. Annals of the New York Academy of Science, 1058, 196- 204 (2005).
25. Cheadle, C., J. Fan, Y. S. Cho-Chung, T. Werner, J. Ray, L. Do, M. Gorospe & K. G. Becker: Control of gene expression during T cell activation: alternate regulation of mRNA transcription and mRNA stability. BMC Genomics, 6, 75 (2005).
26. Fan, J., X. Yang, W. Wang, W. H. Wood, 3rd, K. G. Becker & M. Gorospe: Global analysis of stress-regulated mRNA turnover by using cDNA arrays. Proceedings of the National Academy of Sciences of the United States of America, 99, 10611-6 (2002).
27. Vlasova, I. A., J. McNabb, A. Raghavan, C. Reilly, D. A. Williams, K. A. Bohjanen & P. R. Bohjanen: Coordinate stabilization of growth-regulatory transcripts in T cell malignancies. Genomics, 86, 159-71 (2005). (Pubitemid 40921735)
28. Raghavan, A., R. L. Ogilvie, C. Reilly, M. L. Abelson, S. Raghavan, J. Vasdewani, M. Krathwohl & P. R. Bohjanen: Genome-wide analysis of mRNA decay in resting and activated primary human T lymphocytes. Nucleic Acids Research, 30, 5529-38 (2002). (Pubitemid 36113930)
29. Frevel, M. A., T. Bakheet, A. M. Silva, J. G. Hissong, K. S. Khabar & B. R. Williams: p38 Mitogen-activated protein kinase-dependent and -independent signaling of mRNA stability of AU-rich element-containing transcripts. Molecular & Cellular Biology, 23, 425-36. (2003). (Pubitemid 36050538)
30. Raghavan, A., M. Dhalla, T. Bakheet, R. L. Ogilvie, I. A. Vlasova, K. S. Khabar, B. R. Williams & P. R. Bohjanen: Patterns of coordinate down-regulation of ARE-containing transcripts following immune cell activation. Genomics, 84, 1002-13 (2004). (Pubitemid 39469125)
31. Conne, B., A. Stutz & J. D. Vassalli: The 3′ untranslated region of messenger RNA: A molecular 'hotspot' for pathology? Nature Medicine, 6, 637-41. (2000). (Pubitemid 30398786)
32. Steinman, R. A.: mRNA stability control: a clandestine force in normal and malignant hematopoiesis. Leukemia, 21, 1158-71 (2007). (Pubitemid 46838514)
33. Dixon, D. A.: Dysregulated post-transcriptional control of COX-2 gene expression in cancer. Curr Pharm Des, 10, 635-46 (2004). (Pubitemid 38292390)
34. Lopez de Silanes, I., M. P. Quesada & M. Esteller: Aberrant regulation of messenger RNA 3′-untranslated region in human cancer. Cell Oncol, 29, 1-17 (2007). (Pubitemid 46535188)
35. Seko, Y., S. Cole, W. Kasprzak, B. A. Shapiro & J. A. Ragheb: The role of cytokine mRNA stability in the pathogenesis of autoimmune disease. Autoimmun Rev, 5, 299-305 (2006). (Pubitemid 43868196)
36. Eberhardt, W., A. Doller, S. Akool el & J. Pfeilschifter: Modulation of mRNA stability as a novel therapeutic approach. Pharmacol Ther, 114, 56-73 (2007). (Pubitemid 46498160)
37. Katsanou, V., M. Dimitriou & D. L. Kontoyiannis: Post-transcriptional regulators in inflammation: exploring new avenues in biological therapeutics. Ernst Schering Found Symp Proc, 4, 37-57 (2006).
38. Cuenda, A. & S. Rousseau: p38 MAP-kinases pathway regulation, function and role in human diseases. Biochimica et Biophysica Acta, 1773, 1358-75 (2007). (Pubitemid 47125981)
39. Ashwell, J. D.: The many paths to p38 mitogen-activated protein kinase activation in the immune system. Nat Rev Immunol, 6, 532-40 (2006). (Pubitemid 43980525)
40. Bain, J., H. McLauchlan, M. Elliott & P. Cohen: The specificities of protein kinase inhibitors: an update. Biochemical Journal, 371, 199-204 (2003). (Pubitemid 36458094)
41. Kuma, Y., G. Sabio, J. Bain, N. Shpiro, R. Marquez & A. Cuenda: BIRB796 inhibits all p38 MAPK isoforms in vitro and in vivo. Journal of Biological Chemistry, 280, 19472-9 (2005). (Pubitemid 41379467)
42. Saklatvala, J.: The p38 MAP kinase pathway as a therapeutic target in inflammatory disease. Curr Opin Pharmacol, 4, 372-7 (2004). (Pubitemid 38987064)
43. Schindler, J. F., J. B. Monahan & W. G. Smith: p38 pathway kinases as anti-inflammatory drug targets. J Dent Res, 86, 800-11 (2007).
44. Goldstein, D. M. & T. Gabriel: Pathway to the clinic: inhibition of P38 MAP kinase. A review of ten chemotypes selected for development. Curr Top Med Chem, 5, 1017-29 (2005). (Pubitemid 41582131)
45. Keren, A., Y. Tamir & E. Bengal: The p38 MAPK signaling pathway: a major regulator of skeletal muscle development. Mol Cell Endocrinol, 252, 224-30 (2006).
46. Lluis, F., E. Perdiguero, A. R. Nebreda & P. Munoz-Canoves: Regulation of skeletal muscle gene expression by p38 MAP kinases. Trends in Cell Biology, 16, 36-44 (2006). (Pubitemid 43077093)
47. Dambach, D. M.: Potential adverse effects associated with inhibition of p38alpha/beta MAP kinases. Curr Top Med Chem, 5, 929-39 (2005). (Pubitemid 41582125)
48. Prichett, W., A. Hand, J. Sheilds & D. Dunnington: Mechanism of action of bicyclic imidazoles defines a translational regulatory pathway for tumor necrosis factor alpha. J Inflamm, 45, 97-105 (1995).
49. Young, P., P. McDonnell, D. Dunnington, A. Hand, J. Laydon & J. Lee: Pyridinyl imidazoles inhibit IL-1 and TNF production at the protein level. Agents & Actions, 39 Spec No, C67-9 (1993). (Pubitemid 23276728)
50. Brook, M., G. Sully, A. R. Clark & J. Saklatvala: Regulation of tumour necrosis factor alpha mRNA stability by the mitogen-activated protein kinase p38 signalling cascade. FEBS Letters, 483, 57-61 (2000).
51. Smith, S. J., P. S. Fenwick, A. G. Nicholson, F. Kirschenbaum, T. K. Finney-Hayward, L. S. Higgins, M. A. Giembycz, P. J. Barnes & L. E. Donnelly: Inhibitory effect of p38 mitogen-activated protein kinase inhibitors on cytokine release from human macrophages. Br J Pharmacol, 149, 393-404 (2006). (Pubitemid 44582246)
52. Rutault, K., C. A. Hazzalin & L. C. Mahadevan: Combinations of ERK and p38 MAPK inhibitors ablate tumor necrosis factor-alpha (TNF-alpha ) mRNA induction. Evidence for selective destabilization of TNF-alpha transcripts. Journal of Biological Chemistry, 276, 6666-74. (2001).
53. Thuraisingam, T., Y. Z. Xu, J. Moisan, C. Lachance, J. Garnon, S. Di Marco, M. Gaestel & D. Radzioch: Distinct role of MAPKAPK-2 in the regulation of TNF gene expression by Toll-like receptor 7 and 9 ligands. Molecular Immunology, 44, 3482-91 (2007). (Pubitemid 46754448)
54. Chung, Y. J., H. R. Zhou & J. J. Pestka: Transcriptional and post-transcriptional roles for p38 mitogen-activated protein kinase in up-regulation of TNF-alpha expression by deoxynivalenol (vomitoxin). Toxicol Appl Pharmacol, 193, 188-201 (2003). (Pubitemid 37476434)
55. Rajasingh, J., E. Bord, C. Luedemann, J. Asai, H. Hamada, T. Thorne, G. Qin, D. Goukassian, Y. Zhu, D. W. Losordo & R. Kishore: IL-10-induced TNF-alpha mRNA destabilization is mediated via IL-10 suppression of p38 MAP kinase activation and inhibition of HuR expression. FASEB Journal, 20, 2112-4 (2006).
56. Marchant, A., C. Gueydan, L. Houzet, Z. Amraoui, A. Sels, G. Huez, M. Goldman & V. Kruys: Defective translation of tumor necrosis factor mRNA in lipopolysaccharide-tolerant macrophages. J Inflamm, 46, 114-23 (1996). (Pubitemid 26180842)
57. Abraham, S. M., T. Lawrence, A. Kleiman, P. Warden, M. Medghalchi, J. Tuckermann, J. Saklatvala & A. R. Clark: Antiinflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatase 1. Journal of Experimental Medicine, 203, 1883-9 (2006). (Pubitemid 44188463)
58. Han, J. H., B. Beutler & G. Huez: Complex regulation of tumor necrosis factor mRNA turnover in lipopolysaccharide-activated macrophages. Biochimica et Biophysica Acta, 1090, 22-8 (1991).
59. Kruys, V., K. Kemmer, A. Shakhov, V. Jongeneel & B. Beutler: Constitutive activity of the tumor necrosis factor promoter is canceled by the 3′ untranslated region in nonmacrophage cell lines; a trans-dominant factor overcomes this suppressive effect. Proceedings of the National Academy of Sciences of the United States of America, 89, 673-7 (1992).
60. MacKenzie, S., N. Fernandez-Troy & E. Espel: Post-transcriptional regulation of TNF-alpha during in vitro differentiation of human monocytes/macrophages in primary culture. Journal of Leukocyte Biology, 71, 1026-32 (2002).
61. Kontoyiannis, D., A. Kotlyarov, E. Carballo, L. Alexopoulou, P. J. Blackshear, M. Gaestel, R. Davis, R. Flavell & G. Kollias: Interleukin-10 targets p38 MAPK to modulate ARE-dependent TNF mRNA translation and limit intestinal pathology. EMBO Journal, 20, 3760-70 (2001). (Pubitemid 32691787)
62. Piecyk, M., S. Wax, A. R. Beck, N. Kedersha, M. Gupta, B. Maritim, S. Chen, C. Gueydan, V. Kruys, M. Streuli & P. Anderson: TIA-1 is a translational silencer that selectively regulates the expression of TNF-alpha. EMBO Journal, 19, 4154-63. (2000). (Pubitemid 30608553)
63. Raabe, T., M. Bukrinsky & R. A. Currie: Relative contribution of transcription and translation to the induction of tumor necrosis factor-alpha by lipopolysaccharide. Journal of Biological Chemistry, 273, 974-80 (1998). (Pubitemid 28049193)
64. Garnon, J., C. Lachance, S. Di Marco, Z. Hel, D. Marion, M. C. Ruiz, M. M. Newkirk, E. W. Khandjian & D. Radzioch: Fragile X-related protein FXR1P regulates proinflammatory cytokine tumor necrosis factor expression at the post-transcriptional level. Journal of Biological Chemistry, 280, 5750-63 (2005). (Pubitemid 40280055)
65. Gueydan, C., L. Droogmans, P. Chalon, G. Huez, D. Caput & V. Kruys: Identification of TIAR as a protein binding to the translational regulatory AU-rich element of tumor necrosis factor alpha mRNA. Journal of Biological Chemistry, 274, 2322-6 (1999).
66. Xu, N., P. Loflin, C. Y. Chen & A. B. Shyu: A broader role for AU-rich element-mediated mRNA turnover revealed by a new transcriptional pulse strategy. Nucleic Acids Research, 26, 558-65 (1998). (Pubitemid 28291585)
67. Dean, J. L., S. J. Sarsfield, E. Tsounakou & J. Saklatvala: p38 Mitogen-activated protein kinase stabilizes mRNAs that contain cyclooxygenase-2 and tumor necrosis factor AU-rich elements by inhibiting deadenylation. Journal of Biological Chemistry, 278, 39470-6 (2003). (Pubitemid 37248503)
68. Goedert, M., A. Cuenda, M. Craxton, R. Jakes & P. Cohen: Activation of the novel stress-activated protein kinase SAPK4 by cytokines and cellular stresses is mediated by SKK3 (MKK6); comparison of its substrate specificity with that of other SAP kinases. EMBO Journal, 16, 3563-71 (1997). (Pubitemid 27250050)
69. Cuenda, A., P. Cohen, V. Buee-Scherrer & M. Goedert: Activation of stress-activated protein kinase-3 (SAPK3) by cytokines and cellular stresses is mediated via SAPKK3 (MKK6); comparison of the specificities of SAPK3 and SAPK2 (RK/p38). EMBO Journal, 16, 295-305 (1997). (Pubitemid 27049387)
70. Gaestel, M.: MAPKAP kinases - MKs - two's company, three's a crowd. Nat Rev Mol Cell Biol, 7, 120-30 (2006). (Pubitemid 43278295)
71. Kotlyarov, A. & M. Gaestel: Is MK2 (mitogen-activated protein kinase-activated protein kinase 2) the key for understanding post-transcriptional regulation of gene expression? Biochem Soc Trans, 30, 959-63 (2002). (Pubitemid 36002388)
72. Winzen, R., M. Kracht, B. Ritter, A. Wilhelm, C. Y. Chen, A. B. Shyu, M. Muller, M. Gaestel, K. Resch & H. Holtmann: The p38 MAP kinase pathway signals for cytokine-induced mRNA stabilization via MAP kinase-activated protein kinase 2 and an AU-rich region-targeted mechanism. EMBO Journal, 18, 4969-80 (1999). (Pubitemid 29443799)
73. Mavropoulos, A., G. Sully, A. P. Cope & A. R. Clark: Stabilization of IFN-gamma mRNA by MAPK p38 in IL-12- and IL-18-stimulated human NK cells. Blood, 105, 282-8 (2005). (Pubitemid 40053094)
74. Tchen, C. R., M. Brook, J. Saklatvala & A. R. Clark: The stability of tristetraprolin mRNA is regulated by mitogen-activated protein kinase p38 and by tristetraprolin itself. Journal of Biological Chemistry, 279, 32393-400 (2004). (Pubitemid 39014693)
75. Lasa, M., K. R. Mahtani, A. Finch, G. Brewer, J. Saklatvala & A. R. Clark: Regulation of cyclooxygenase 2 mRNA stability by the mitogen-activated protein kinase p38 signaling cascade. Molecular & Cellular Biology, 20, 4265-74 (2000). (Pubitemid 30346621)
76. Han, Q., J. Leng, D. Bian, C. Mahanivong, K. A. Carpenter, Z. K. Pan, J. Han & S. Huang: Rac1-MKK3- p38-MAPKAPK2 pathway promotes urokinase plasminogen activator mRNA stability in invasive breast cancer cells. Journal of Biological Chemistry, 277, 48379- 85 (2002). (Pubitemid 35470794)
77. Kotlyarov, A., A. Neininger, C. Schubert, R. Eckert, C. Birchmeier, H. D. Volk & M. Gaestel: MAPKAP kinase 2 is essential for LPS-induced TNF-alpha biosynthesis. Nature Cell Biology, 1, 94-7 (1999). (Pubitemid 129501950)
78. Ronkina, N., A. Kotlyarov, O. Dittrich-Breiholz, M. Kracht, E. Hitti, K. Milarski, R. Askew, S. Marusic, L. L. Lin, M. Gaestel & J. B. Telliez: The mitogen-activated protein kinase (MAPK)-activated protein kinases MK2 and MK3 cooperate in stimulation of tumor necrosis factor biosynthesis and stabilization of p38 MAPK. Molecular & Cellular Biology, 27, 170-81 (2007). (Pubitemid 46013242)
79. Neininger, A., D. Kontoyiannis, A. Kotlyarov, R. Winzen, R. Eckert, H. D. Volk, H. Holtmann, G. Kollias & M. Gaestel: MK2 targets AU-rich elements and regulates biosynthesis of tumor necrosis factor and interleukin-6 independently at different post-transcriptional levels. Journal of Biological Chemistry, 277, 3065-8 (2002). (Pubitemid 34953164)
80. Wang, X., L. Xu, H. Wang, P. R. Young, M. Gaestel & G. Z. Feuerstein: Mitogen-activated protein kinase-activated protein (MAPKAP) kinase 2 deficiency protects brain from ischemic injury in mice. Journal of Biological Chemistry, 277, 43968-72 (2002). (Pubitemid 36157821)
81. Culbert, A. A., S. D. Skaper, D. R. Howlett, N. A. Evans, L. Facci, P. E. Soden, Z. M. Seymour, F. Guillot, M. Gaestel & J. C. Richardson: MAPK-activated protein kinase 2 deficiency in microglia inhibits pro-inflammatory mediator release and resultant neurotoxicity. Relevance to neuroinflammation in a transgenic mouse model of Alzheimer disease. Journal of Biological Chemistry, 281, 23658-67 (2006). (Pubitemid 44274141)
82. Tietz, A. B., A. Malo, J. Diebold, A. Kotlyarov, A. Herbst, F. T. Kolligs, B. Brandt-Nedelev, W. Halangk, M. Gaestel, B. Goke & C. Schafer: Gene deletion of MK2 inhibits TNF-alpha and IL-6 and protects against cerulein-induced pancreatitis. Am J Physiol Gastrointest Liver Physiol, 290, G1298-306 (2006). (Pubitemid 43788313)
83. Hegen, M., M. Gaestel, C. L. Nickerson-Nutter, L. L. Lin & J. B. Telliez: MAPKAP kinase 2-deficient mice are resistant to collagen-induced arthritis. Journal of Immunology, 177, 1913-7 (2006). (Pubitemid 44092531)
84. Hitti, E., T. Iakovleva, M. Brook, S. Deppenmeier, A. D. Gruber, D. Radzioch, A. R. Clark, P. J. Blackshear, A. Kotlyarov & M. Gaestel: Mitogen-activated protein kinase-activated protein kinase 2 regulates tumor necrosis factor mRNA stability and translation mainly by altering tristetraprolin expression, stability, and binding to adenine/uridine-rich element. Molecular & Cellular Biology, 26, 2399-407 (2006). (Pubitemid 43346938)
85. Kontoyiannis, D., M. Pasparakis, T. T. Pizarro, F. Cominelli & G. Kollias: Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies. Immunity, 10, 387-98 (1999). (Pubitemid 29165293)
86. Clark, A. R., J. L. Dean & J. Saklatvala: Post-transcriptional regulation of gene expression by mitogen-activated protein kinase p38. FEBS Letters, 546, 37-44 (2003). (Pubitemid 36782279)
87. Winzen, R., G. Gowrishankar, F. Bollig, N. Redich, K. Resch & H. Holtmann: Distinct domains of AU-rich elements exert different functions in mRNA destabilization and stabilization by p38 mitogen-activated protein kinase or HuR. Molecular & Cellular Biology, 24, 4835-47 (2004). (Pubitemid 38668049)
88. Sully, G., J. L. Dean, R. Wait, L. Rawlinson, T. Santalucia, J. Saklatvala & A. R. Clark: Structural and functional dissection of a conserved destabilizing element of cyclo-oxygenase-2 mRNA: evidence against the involvement of AUF-1 (AU-rich element/poly (U)-binding/degradation factor-1), AUF-2, tristetraprolin, HuR (Hu antigen R) or FBP1 (far-upstream- sequenceelement- binding protein 1). Biochemical Journal, 377, 629-39 (2004). (Pubitemid 38221834)
89. Rousseau, S., N. Morrice, M. Peggie, D. G. Campbell, M. Gaestel & P. Cohen: Inhibition of SAPK2a/p38 prevents hnRNP A0 phosphorylation by MAPKAP-K2 and its interaction with cytokine mRNAs. EMBO Journal, 21, 6505-14. (2002). (Pubitemid 35448428)
90. Numahata, K., T. Komagata, N. Hirasawa, K. Someya, Y. Q. Xiao & K. Ohuchi: Analysis of the mechanism regulating the stability of rat macrophage inflammatory protein-2 mRNA in RBL-2H3 cells. J Cell Biochem, 90, 976-86 (2003). (Pubitemid 37467113)
91. Deleault, K. M., S. J. Skinner & S. A. Brooks: Tristetraprolin regulates TNF TNF-alpha mRNA stability via a proteasome dependent mechanism involving the combined action of the ERK and p38 pathways. Molecular Immunology, 45, 13-24 (2008). (Pubitemid 47331659)
92. Dumitru, C. D., J. D. Ceci, C. Tsatsanis, D. Kontoyiannis, K. Stamatakis, J. Lin, C. Patriotis, N. A. Jenkins, N. G. Copeland, G. Kollias & P. N. Tsichlis: TNF-alpha Induction by LPS Is Regulated Post-transcriptionally via a Tpl2/ERK-Dependent Pathway. Cell 1071-1083 (2000). (Pubitemid 32040907)
93. Skinner, S. J., K. M. Deleault, R. Fecteau & S. A. Brooks: Extracellular signal-regulated kinase regulation of tumor necrosis factor-alpha mRNA nucleocytoplasmic transport requires TAP/NxT1 binding and the AU-Rich element. Journal of Biological Chemistry (2007).
94. Phelps, M., A. Phillips, M. Darley & J. P. Blaydes: MEK-ERK signaling controls Hdm2 oncoprotein expression by regulating hdm2 mRNA export to the cytoplasm. Journal of Biological Chemistry, 280, 16651-8 (2005). (Pubitemid 41389122)
95. Swantek, J. L., M. H. Cobb & T. D. Geppert: Jun N-terminal kinase/stress-activated protein kinase (JNK/SAPK) is required for lipopolysaccharide stimulation of tumor necrosis factor alpha (TNF-alpha) translation: glucocorticoids inhibit TNF-alpha translation by blocking JNK/SAPK. Molecular & Cellular Biology, 17, 6274-82 (1997). (Pubitemid 27451171)
96. Lasa, M., S. M. Abraham, C. Boucheron, J. Saklatvala & A. R. Clark: Dexamethasone causes sustained expression of mitogen-activated protein kinase (MAPK) phosphatase 1 and phosphatase-mediated inhibition of MAPK p38. Molecular & Cellular Biology, 22, 7802-11. (2002). (Pubitemid 35217291)
97. Chen, P., J. Li, J. Barnes, G. C. Kokkonen, J. C. Lee & Y. Liu: Restraint of proinflammatory cytokine biosynthesis by mitogen-activated protein kinase phosphatase-1 in lipopolysaccharide-stimulated macrophages. Journal of Immunology, 169, 6408-16. (2002). (Pubitemid 36903490)
98. Chen, C. Y., F. Del Gatto-Konczak, Z. Wu & M. Karin: Stabilization of interleukin-2 mRNA by the c-Jun NH2-terminal kinase pathway. Science, 280, 1945-9. (1998). (Pubitemid 28299404)
99. Chen, C. Y., R. Gherzi, J. S. Andersen, G. Gaietta, K. Jurchott, H. D. Royer, M. Mann & M. Karin: Nucleolin and YB-1 are required for JNK-mediated interleukin-2 mRNA stabilization during T-cell activation. Genes & Development, 14, 1236-48. (2000). (Pubitemid 30327504)
100. Lo, S. J., C. C. Lee & H. J. Lai: The nucleolus: reviewing oldies to have new understandings. Cell Res, 16, 530-8 (2006).
101. Kohno, K., H. Izumi, T. Uchiumi, M. Ashizuka & M. Kuwano: The pleiotropic functions of the Y-box-binding protein, YB-1. Bioessays, 25, 691-8 (2003). (Pubitemid 36850797)
102. Fukunaga, R. & T. Hunter: MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates. EMBO Journal, 16, 1921-33 (1997). (Pubitemid 27170953)
103. Waskiewicz, A. J., A. Flynn, C. G. Proud & J. A. Cooper: Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2. EMBO Journal, 16, 1909-20 (1997). (Pubitemid 27170952)
104. Buxade, M., J. L. Parra, S. Rousseau, N. Shpiro, R. Marquez, N. Morrice, J. Bain, E. Espel & C. G. Proud: The Mnks are novel components in the control of TNF alpha biosynthesis and phosphorylate and regulate hnRNP A1. Immunity, 23, 177-89 (2005). (Pubitemid 41169287)
105. Buxade, M., N. Morrice, D. L. Krebs & C. G. Proud: The PSF.p54nrb complex is a novel Mnk substrate that binds the mRNA for tumor necrosis factor alpha. Journal of Biological Chemistry, 283, 57-65 (2008).
106. Andersson, K. & R. Sundler: Post-transcriptional regulation of TNFalpha expression via eukaryotic initiation factor 4E (eIF4E) phosphorylation in mouse macrophages. Cytokine, 33, 52-7 (2006). (Pubitemid 43220353)
107. Kjellerup, R. B., K. Kragballe, L. Iversen & C. Johansen: Pro-inflammatory cytokine release in keratinocytes is mediated through the MAPK signal-integrating kinases. Exp Dermatol (2007).
108. Rowlett, R. M., C. A. Chrestensen, M. Nyce, M. G. Harp, J. W. Pelo, F. Cominelli, P. B. Ernst, T. T. Pizarro, T. W. Sturgill & M. T. Worthington: MNK kinases regulate multiple TLR pathways and innate proinflammatory cytokines in macrophages. Am J Physiol Gastrointest Liver Physiol, 294, G452-9 (2008). (Pubitemid 351253336)
109. Ueda, T., R. Watanabe-Fukunaga, H. Fukuyama, S. Nagata & R. Fukunaga: Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development. Molecular & Cellular Biology, 24, 6539- 49 (2004). (Pubitemid 38944335)
110. Carrick, D. M., W. S. Lai & P. J. Blackshear: The tandem CCCH zinc finger protein tristetraprolin and its relevance to cytokine mRNA turnover and arthritis. Arthritis Res Ther, 6, 248-64 (2004). (Pubitemid 39490013)
111. Brook, M., C. R. Tchen, T. Santalucia, J. McIlrath, J. S. Arthur, J. Saklatvala & A. R. Clark: Posttranslational regulation of tristetraprolin subcellular localization and protein stability by p38 mitogen-activated protein kinase and extracellular signal-regulated kinase pathways. Molecular & Cellular Biology, 26, 2408-18 (2006). (Pubitemid 43346939)
112. Mahtani, K. R., M. Brook, J. L. Dean, G. Sully, J. Saklatvala & A. R. Clark: Mitogen-activated protein kinase p38 controls the expression and post-translational modification of tristetraprolin, a regulator of tumor necrosis factor alpha mRNA stability. Molecular & Cellular Biology, 21, 6461-9. (2001). (Pubitemid 32927414)
113. Brooks, S. A., J. E. Connolly & W. F. Rigby: The role of mRNA turnover in the regulation of tristetraprolin expression: evidence for an extracellular signal-regulated kinase-specific, AU-rich element-dependent, autoregulatory pathway. Journal of Immunology, 172, 7263-71 (2004). (Pubitemid 38747585)
114. Lai, W. S., J. S. Parker, S. F. Grissom, D. J. Stumpo & P. J. Blackshear: Novel mRNA targets for tristetraprolin (TTP) identified by global analysis of stabilized transcripts in TTP-deficient fibroblasts. Molecular & Cellular Biology, 26, 9196-208 (2006). (Pubitemid 44904416)
115. Raghavan, A., R. L. Robison, J. McNabb, C. R. Miller, D. A. Williams & P. R. Bohjanen: HuA and tristetraprolin are induced following T cell activation and display distinct but overlapping RNA binding specificities. Journal of Biological Chemistry, 276, 47958-65 (2001).
116. Ogilvie, R. L., M. Abelson, H. H. Hau, I. Vlasova, P. J. Blackshear & P. R. Bohjanen: Tristetraprolin down regulates IL-2 gene expression through AU-rich element mediated mRNA decay. Journal of Immunology, 174, 953- 61 (2005). (Pubitemid 40094291)
117. Frasca, D., A. M. Landin, J. P. Alvarez, P. J. Blackshear, R. L. Riley & B. B. Blomberg: Tristetraprolin, a negative regulator of mRNA stability, is increased in old B cells and is involved in the degradation of E47 mRNA. Journal of Immunology, 179, 918-27 (2007).
118. Dean, J. L., G. Sully, A. R. Clark & J. Saklatvala: The involvement of AU-rich element-binding proteins in p38 mitogen-activated protein kinase pathway-mediated mRNA stabilisation. Cell Signal, 16, 1113-21 (2004). (Pubitemid 38900514)
119. Carrick, D. M. & P. J. Blackshear: Comparative expression of tristetraprolin (TTP) family member transcripts in normal human tissues and cancer cell lines. Archives of Biochemistry & Biophysics, 462, 278-85 (2007). (Pubitemid 46856329)
120. Lai, W. S., E. Carballo, J. M. Thorn, E. A. Kennington & P. J. Blackshear: Interactions of CCCH zinc finger proteins with mRNA. Binding of tristetraprolin-related zinc finger proteins to Au-rich elements and destabilization of mRNA. Journal of Biological Chemistry, 275, 17827-37 (2000). (Pubitemid 30430835)
121. Lai, W. S. & P. J. Blackshear: Interactions of CCCH zinc finger proteins with mRNA: tristetraprolin-mediated AU-rich element-dependent mRNA degradation can occur in the absence of a poly (A) tail. Journal of Biological Chemistry, 276, 23144-54 (2001).
122. Stumpo, D. J., N. A. Byrd, R. S. Phillips, S. Ghosh, R. R. Maronpot, T. Castranio, E. N. Meyers, Y. Mishina & P. J. Blackshear: Chorioallantoic fusion defects and embryonic lethality resulting from disruption of Zfp36L1, a gene encoding a CCCH tandem zinc finger protein of the Tristetraprolin family. Molecular & Cellular Biology, 24, 6445-55 (2004). (Pubitemid 38891143)
123. Bell, S. E., M. J. Sanchez, O. Spasic-Boskovic, T. Santalucia, L. Gambardella, G. J. Burton, J. J. Murphy, J. D. Norton, A. R. Clark & M. Turner: The RNA binding protein Zfp36l1 is required for normal vascularisation and post-transcriptionally regulates VEGF expression. Dev Dyn, 235, 3144-55 (2006). (Pubitemid 44749704)
124. Ramos, S. B., D. J. Stumpo, E. A. Kennington, R. S. Phillips, C. B. Bock, F. Ribeiro-Neto & P. J. Blackshear: The CCCH tandem zinc-finger protein Zfp36l2 is crucial for female fertility and early embryonic development. Development, 131, 4883-93 (2004). (Pubitemid 39433473)
125. Blackshear, P. J., W. S. Lai, E. A. Kennington, G. Brewer, G. M. Wilson, X. Guan & P. Zhou: Characteristics of the interaction of a synthetic human tristetraprolin tandem zinc finger peptide with AU-rich element-containing RNA substrates. Journal of Biological Chemistry, 278, 19947-55 (2003). (Pubitemid 36799186)
126. Brewer, B. Y., J. Malicka, P. J. Blackshear & G. M. Wilson: RNA sequence elements required for high affinity binding by the zinc finger domain of tristetraprolin: conformational changes coupled to the bipartite nature of Au-rich MRNA-destabilizing motifs. Journal of Biological Chemistry, 279, 27870-7 (2004). (Pubitemid 38900055)
127. Worthington, M. T., J. W. Pelo, M. A. Sachedina, J. L. Applegate, K. O. Arseneau & T. T. Pizarro: RNA binding properties of the AU-rich element-binding recombinant Nup475/TIS11/tristetraprolin protein. Journal of Biological Chemistry, 277, 48558-64. (2002). (Pubitemid 35470816)
128. Stoecklin, G., S. A. Tenenbaum, T. Mayo, S. V. Chittur, A. D. George, T. E. Baroni, P. J. Blackshear & P. Anderson: Genome-wide analysis identifies interleukin-10 mRNA as target of tristetraprolin. Journal of Biological Chemistry (2008).
129. Hudson, B. P., M. A. Martinez-Yamout, H. J. Dyson & P. E. Wright: Recognition of the mRNA AU-rich element by the zinc finger domain of TIS11d. Nat Struct Mol Biol, 11, 257-64 (2004). (Pubitemid 38282771)
130. Brewer, B. Y., J. D. Ballin, E. J. Fialcowitz-White, P. J. Blackshear & G. M. Wilson: Substrate dependence of conformational changes in the RNA-binding domain of tristetraprolin assessed by fluorescence spectroscopy of tryptophan mutants. Biochemistry, 45, 13807-17 (2006). (Pubitemid 44788749)
131. Taylor, G. A., M. J. Thompson, W. S. Lai & P. J. Blackshear: Mitogens stimulate the rapid nuclear to cytosolic translocation of tristetraprolin, a potential zincfinger transcription factor. Mol Endocrinol, 10, 140-6 (1996). (Pubitemid 26042546)
132. Phillips, R. S., S. B. Ramos & P. J. Blackshear: Members of the tristetraprolin family of tandem CCCH zinc finger proteins exhibit CRM1-dependent nucleocytoplasmic shuttling. Journal of Biological Chemistry, 277, 11606-13. (2002). (Pubitemid 34952933)
133. Carman, J. A. & S. G. Nadler: Direct association of tristetraprolin with the nucleoporin CAN/Nup214. Biochemical & Biophysical Research Communications, 315, 445-9 (2004). (Pubitemid 38183126)
134. Murata, T., Y. Yoshino, N. Morita & N. Kaneda: Identification of nuclear import and export signals within the structure of the zinc finger protein TIS11. Biochemical & Biophysical Research Communications, 293, 1242-7 (2002). (Pubitemid 34681075)
135. Johnson, B. A., J. R. Stehn, M. B. Yaffe & T. K. Blackwell: Cytoplasmic localization of tristetraprolin involves 14-3-3-dependent and -independent mechanisms. Journal of Biological Chemistry, 277, 18029-36. (2002). (Pubitemid 34967615)
136. Mackintosh, C.: Dynamic interactions between 14-3-3 proteins and phosphoproteins regulate diverse cellular processes. Biochemical Journal, 381, 329-42 (2004). (Pubitemid 38976512)
137. Porter, G. W., F. R. Khuri & H. Fu: Dynamic 14-3-3/client protein interactions integrate survival and apoptotic pathways. Semin Cancer Biol, 16, 193-202 (2006). (Pubitemid 43796125)
138. Aitken, A.: 14-3-3 proteins: a historic overview. Semin Cancer Biol, 16, 162-72 (2006). (Pubitemid 43796128)
139. Lai, W. S., E. Carballo, J. R. Strum, E. A. Kennington, R. S. Phillips & P. J. Blackshear: Evidence that tristetraprolin binds to AU-rich elements and promotes the deadenylation and destabilization of tumor necrosis factor alpha mRNA. Molecular & Cellular Biology, 19, 4311-23 (1999). (Pubitemid 29242006)
140. Carballo, E., W. S. Lai & P. J. Blackshear: Evidence that tristetraprolin is a physiological regulator of granulocyte-macrophage colony-stimulating factor messenger RNA deadenylation and stability. Blood, 95, 1891-9 (2000). (Pubitemid 30151623)
141. Lai, W. S., D. M. Carrick & P. J. Blackshear: Influence of nonameric AU-rich tristetraprolin binding sites on mRNA deadenylation and turnover. Journal of Biological Chemistry (2005).
142. Taylor, G. A., E. Carballo, D. M. Lee, W. S. Lai, M. J. Thompson, D. D. Patel, D. I. Schenkman, G. S. Gilkeson, H. E. Broxmeyer, B. F. Haynes & P. J. Blackshear: A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency. Immunity, 4, 445-54 (1996). (Pubitemid 26354654)
143. Carballo, E., G. S. Gilkeson & P. J. Blackshear: Bone marrow transplantation reproduces the tristetraprolindeficiency syndrome in recombination activating gene-2 (-/-) mice. Evidence that monocyte/macrophage progenitors may be responsible for TNFalpha overproduction. Journal of Clinical Investigation, 100, 986-95 (1997). (Pubitemid 27386282)
144. Carballo, E., W. S. Lai & P. J. Blackshear: Feedback inhibition of macrophage tumor necrosis factor-alpha production by tristetraprolin. Science, 281, 1001-5 (1998). (Pubitemid 28399252)
145. Phillips, K., N. Kedersha, L. Shen, P. J. Blackshear & P. Anderson: Arthritis suppressor genes TIA-1 and TTP dampen the expression of tumor necrosis factor {alpha}, cyclooxygenase 2, and inflammatory arthritis. Proceedings of the National Academy of Sciences of the United States of America, 101, 2011-2016 (2004). (Pubitemid 38229006)
146. Datta, S., R. Biswas, M. Novotny, P. G. Pavicic, Jr., T. Herjan, P. Mandal & T. A. Hamilton: Tristetraprolin Regulates CXCL1 (KC) mRNA Stability. Journal of Immunology, 180, 2545-52 (2008).
147. Taylor, G. A., M. J. Thompson, W. S. Lai & P. J. Blackshear: Phosphorylation of tristetraprolin, a potential zinc finger transcription factor, by mitogen stimulation in intact cells and by mitogen-activated protein kinase in vitro. Journal of Biological Chemistry, 270, 13341-7 (1995).
148. Cao, H., J. S. Tuttle & P. J. Blackshear: Immunological characterization of tristetraprolin as a low abundance, inducible, stable cytosolic protein. Journal of Biological Chemistry, 279, 21489-99 (2004). (Pubitemid 38656559)
149. Cao, H., L. J. Deterding, J. D. Venable, E. A. Kennington, J. R. Yates, 3rd, K. B. Tomer & P. J. Blackshear: Identification of the anti-inflammatory protein tristetraprolin as a hyperphosphorylated protein by mass spectrometry and site-directed mutagenesis. Biochemical Journal, 394, 285-97 (2006). (Pubitemid 43259679)
150. Carballo, E., H. Cao, W. S. Lai, E. A. Kennington, D. Campbell & P. J. Blackshear: Decreased sensitivity of tristetraprolin-deficient cells to p38 inhibitors suggests the involvement of tristetraprolin in the p38 signaling pathway. Journal of Biological Chemistry, 276, 42580-7 (2001).
151. Zhu, W., M. A. Brauchle, F. Di Padova, H. Gram, L. New, K. Ono, J. S. Downey & J. Han: Gene suppression by tristetraprolin and release by the p38 pathway. Am J Physiol Lung Cell Mol Physiol, 281, L499-508. (2001).
152. Cao, H., F. Dzineku & P. J. Blackshear: Expression and purification of recombinant tristetraprolin that can bind to tumor necrosis factor-alpha mRNA and serve as a substrate for mitogen-activated protein kinases. Archives of Biochemistry & Biophysics, 412, 106-120. (2003). (Pubitemid 36324370)
153. Cao, H.: Expression, purification, and biochemical characterization of the antiinflammatory tristetraprolin: a zinc-dependent mRNA binding protein affected by post-translational modifications. Biochemistry, 43, 13724-38 (2004). (Pubitemid 39431056)
154. Cao, H., L. J. Deterding & P. J. Blackshear: Phosphorylation site analysis of the anti-inflammatory and mRNA-destabilizing protein tristetraprolin. Expert Rev Proteomics, 4, 711-26 (2007). (Pubitemid 350261438)
155. Chrestensen, C. A., M. J. Schroeder, J. Shabanowitz, D. F. Hunt, J. W. Pelo, M. T. Worthington & T. W. Sturgill: MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 binding. Journal of Biological Chemistry, 279, 10176-84 (2004). (Pubitemid 38372622)
156. Sun, L., G. Stoecklin, S. Van Way, V. Hinkovska-Galcheva, R. F. Guo, P. Anderson & T. P. Shanley: Tristetraprolin (TTP)-14-3-3 complex formation protects TTP from dephosphorylation by protein phosphatase 2a and stabilizes tumor necrosis factor-alpha mRNA. Journal of Biological Chemistry, 282, 3766-77 (2007). (Pubitemid 47084478)
157. Benjamin, D., M. Schmidlin, L. Min, B. Gross & C. Moroni: BRF1 protein turnover and mRNA decay activity are regulated by protein kinase B at the same phosphorylation sites. Molecular & Cellular Biology, 26, 9497-507 (2006). (Pubitemid 44904441)
158. Stoecklin, G., T. Stubbs, N. Kedersha, S. Wax, W. F. Rigby, T. K. Blackwell & P. Anderson: MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay. EMBO Journal, 23, 1313-1324 (2004). (Pubitemid 38525003)
159. Marderosian, M., A. Sharma, A. P. Funk, R. Vartanian, J. Masri, O. D. Jo & J. F. Gera: Tristetraprolin regulates Cyclin D1 and c-Myc mRNA stability in response to rapamycin in an Akt-dependent manner via p38 MAPK signaling. Oncogene, 25, 6277- 90 (2006). (Pubitemid 44564744)
160. Kedersha, N. & P. Anderson: Stress granules: sites of mRNA triage that regulate mRNA stability and translatability. Biochem Soc Trans, 30, 963-9 (2002). (Pubitemid 36002389)
161. Kedersha, N., G. Stoecklin, M. Ayodele, P. Yacono, J. Lykke-Andersen, M. J. Fitzler, D. Scheuner, R. J. Kaufman, D. E. Golan & P. Anderson: Stress granules and processing bodies are dynamically linked sites of mRNP remodeling. Journal of Cell Biology, 169, 871-84 (2005). (Pubitemid 41002864)
162. Corcoran, J. A., W. L. Hsu & J. R. Smiley: Herpes simplex virus ICP27 is required for virus-induced stabilization of the ARE-containing IEX-1 mRNA encoded by the human IER3 gene. Journal of Virology, 80, 9720-9 (2006). (Pubitemid 44435646)
163. Essafi-Benkhadir, K., C. Onesto, E. Stebe, C. Moroni & G. Pages: Tristetraprolin inhibits Ras-dependent tumor vascularization by inducing vascular endothelial growth factor mRNA degradation. Molecular Biology of the Cell, 18, 4648-58 (2007). (Pubitemid 350060189)
164. Brennan, C. M. & J. A. Steitz: HuR and mRNA stability. Cell Mol Life Sci, 58, 266-77. (2001). (Pubitemid 32217358)
165. Lopez de Silanes, I., M. Zhan, A. Lal, X. Yang & M. Gorospe: Identification of a target RNA motif for RNA-binding protein HuR. Proceedings of the National Academy of Sciences of the United States of America, 101, 2987-92 (2004). (Pubitemid 38327723)
166. Lopez de Silanes, I., J. Fan, C. J. Galban, R. G. Spencer, K. G. Becker & M. Gorospe: Global analysis of HuR-regulated gene expression in colon cancer systems of reducing complexity. Gene Expr, 12, 49-59 (2004). (Pubitemid 39238136)
167. Lopez de Silanes, I., A. Lal & M. Gorospe: HuR: post-transcriptional paths to malignancy. RNA Biol, 2, 11-3 (2005).
168. Abdelmohsen, K., A. Lal, H. H. Kim & M. Gorospe: Post-transcriptional orchestration of an anti-apoptotic program by HuR. Cell Cycle, 6, 1288-92 (2007). (Pubitemid 47327958)
169. Dixon, D. A., N. D. Tolley, P. H. King, L. B. Nabors, T. M. McIntyre, G. A. Zimmerman & S. M. Prescott: Altered expression of the mRNA stability factor HuR promotes cyclooxygenase-2 expression in colon cancer cells. Journal of Clinical Investigation, 108, 1657-65. (2001). (Pubitemid 33144876)
170. Lopez de Silanes, I., J. Fan, X. Yang, A. B. Zonderman, O. Potapova, E. S. Pizer & M. Gorospe: Role of the RNA-binding protein HuR in colon carcinogenesis. Oncogene, 22, 7146-54 (2003). (Pubitemid 37378547)
171. Jin, S. H., T. I. Kim, K. M. Yang & W. H. Kim: Thalidomide destabilizes cyclooxygenase-2 mRNA by inhibiting p38 mitogen-activated protein kinase and cytoplasmic shuttling of HuR. Eur J Pharmacol, 558, 14- 20 (2007). (Pubitemid 46331839)
172. Li, B., J. Si & J. W. Dewille: Ultraviolet radiation (UVR) activates p38 MAP kinase and induces post-transcriptional stabilization of the C/EBPdelta mRNA in G (0) growth arrested mammary epithelial cells. J Cell Biochem (2007).
173. Lin, F. Y., Y. H. Chen, Y. W. Lin, J. S. Tsai, J. W. Chen, H. J. Wang, Y. L. Chen, C. Y. Li & S. J. Lin: The role of human antigen R, an RNA-binding protein, in mediating the stabilization of toll-like receptor 4 mRNA induced by endotoxin: a novel mechanism involved in vascular inflammation. Arterioscler Thromb Vasc Biol, 26, 2622-9 (2006).
174. Song, I. S., S. Tatebe, W. Dai & M. T. Kuo: Delayed mechanism for induction of gamma-glutamylcysteine synthetase heavy subunit mRNA stability by oxidative stress involving p38 mitogen-activated protein kinase signaling. Journal of Biological Chemistry, 280, 28230-40 (2005). (Pubitemid 41105719)
175. Subbaramaiah, K., T. P. Marmo, D. A. Dixon & A. J. Dannenberg: Regulation of cyclooxgenase-2 mRNA stability by taxanes: evidence for involvement of p38, MAPKAPK-2, and HuR. Journal of Biological Chemistry, 278, 37637-47 (2003). (Pubitemid 37175287)
176. Tran, H., F. Maurer & Y. Nagamine: Stabilization of urokinase and urokinase receptor mRNAs by HuR is linked to its cytoplasmic accumulation induced by activated mitogen-activated protein kinase-activated protein kinase 2. Molecular & Cellular Biology, 23, 7177-88 (2003). (Pubitemid 37211000)
177. Ford, L. P., J. Watson, J. D. Keene & J. Wilusz: ELAV proteins stabilize deadenylated intermediates in a novel in vitro mRNA deadenylation/degradation system. Genes And Development, 13, 188-201 (1999). (Pubitemid 29061949)
178. Peng, S. S., C. Y. Chen, N. Xu & A. B. Shyu: RNA stabilization by the AU-rich element binding protein, HuR, an ELAV protein. EMBO Journal, 17, 3461-70 (1998). (Pubitemid 28279518)
179. Seko, Y., H. Azmi, R. Fariss & J. A. Ragheb: Selective cytoplasmic translocation of HuR and site-specific binding to the interleukin-2 mRNA are not sufficient for CD28-mediated stabilization of the mRNA. Journal of Biological Chemistry, 279, 33359-67 (2004). (Pubitemid 39062984)
180. Wang, W., X. Yang, T. Kawai, I. Lopez de Silanes, K. Mazan-Mamczarz, P. Chen, Y. M. Chook, C. Quensel, M. Kohler & M. Gorospe: AMP-activated protein kinase-regulated phosphorylation and acetylation of importin alpha1: involvement in the nuclear import of RNA-binding protein HuR. Journal of Biological Chemistry, 279, 48376- 88 (2004). (Pubitemid 39540994)
181. Abdelmohsen, K., R. Pullmann, Jr., A. Lal, H. H. Kim, S. Galban, X. Yang, J. D. Blethrow, M. Walker, J. Shubert, D. A. Gillespie, H. Furneaux & M. Gorospe: Phosphorylation of HuR by Chk2 regulates SIRT1 expression. Molecular Cell, 25, 543-57 (2007). (Pubitemid 46274441)
182. Doller, A., A. Huwiler, R. Muller, H. H. Radeke, J. Pfeilschifter & W. Eberhardt: Protein kinase C alpha-dependent phosphorylation of the mRNA-stabilizing factor HuR: implications for post-transcriptional regulation of cyclooxygenase-2. Molecular Biology of the Cell, 18, 2137- 48 (2007). (Pubitemid 46911365)
183. Zou, T., L. Liu, J. N. Rao, B. S. Marasa, J. Chen, L. Xiao, H. Zhou, M. Gorospe & J. Y. Wang: Polyamines modulate the subcellular localization of RNA-binding protein HuR through AMP-activated protein kinase-regulated phosphorylation and acetylation of importin alpha1. Biochemical Journal, 409, 389-98 (2008). (Pubitemid 351184957)
184. Ruggiero, T., M. Trabucchi, M. Ponassi, G. Corte, C. Y. Chen, L. al-Haj, K. S. Khabar, P. Briata & R. Gherzi: Identification of a set of KSRP target transcripts upregulated by PI3K-AKT signaling. BMC Mol Biol, 8, 28 (2007).
185. Gherzi, R., M. Trabucchi, M. Ponassi, T. Ruggiero, G. Corte, C. Moroni, C. Y. Chen, K. S. Khabar, J. S. Andersen & P. Briata: The RNA-binding protein KSRP promotes decay of beta-catenin mRNA and is inactivated by PI3K-AKT signaling. PLoS Biol, 5, e5 (2006).
186. Briata, P., S. V. Forcales, M. Ponassi, G. Corte, C. Y. Chen, M. Karin, P. L. Puri & R. Gherzi: p38-dependent phosphorylation of the mRNA decay-promoting factor KSRP controls the stability of select myogenic transcripts. Molecular Cell, 20, 891-903 (2005). (Pubitemid 41814878)
187. Winzen, R., B. K. Thakur, O. Dittrich-Breiholz, M. Shah, N. Redich, S. Dhamija, M. Kracht & H. Holtmann: Functional analysis of KSRP interaction with the AU-rich element of interleukin-8 and identification of inflammatory mRNA targets. Molecular & Cellular Biology, 27, 8388- 400 (2007). (Pubitemid 350234249)
188. Garcia-Mayoral, M. F., D. Hollingworth, L. Masino, I. Diaz-Moreno, G. Kelly, R. Gherzi, C. F. Chou, C. Y. Chen & A. Ramos: The structure of the C-terminal KH domains of KSRP reveals a noncanonical motif important for mRNA degradation. Structure, 15, 485-98 (2007). (Pubitemid 46551731)
189. Zhang, W., B. J. Wagner, K. Ehrenman, A. W. Schaefer, C. T. DeMaria, D. Crater, K. DeHaven, L. Long & G. Brewer: Purification, characterization, and cDNA cloning of an AU-rich element RNA-binding protein, AUF1. Molecular And Cellular Biology, 13, 7652-65 (1993). (Pubitemid 23354290)
190. Lu, J. Y., N. Sadri & R. J. Schneider: Endotoxic shock in AUF1 knockout mice mediated by failure to degrade proinflammatory cytokine mRNAs. Genes & Development, 20, 3174-84 (2006). (Pubitemid 44790631)
191. Sarkar, B., Q. Xi, C. He & R. J. Schneider: Selective degradation of AU-rich mRNAs promoted by the p37 AUF1 protein isoform. Molecular & Cellular Biology, 23, 6685-93 (2003). (Pubitemid 37075777)
192. Shen, Z. J., S. Esnault & J. S. Malter: The peptidylprolyl isomerase Pin1 regulates the stability of granulocyte-macrophage colony-stimulating factor mRNA in activated eosinophils. Nat Immunol, 6, 1280-7 (2005). (Pubitemid 43045640)
193. Xu, N., C. Y. Chen & A. B. Shyu: Versatile role for hnRNP D isoforms in the differential regulation of cytoplasmic mRNA turnover. Molecular & Cellular Biology, 21, 6960-71 (2001). (Pubitemid 32911256)
194. He, C. & R. Schneider: 14-3-3sigma is a p37 AUF1-binding protein that facilitates AUF1 transport and AU-rich mRNA decay. EMBO Journal, 25, 3823-31 (2006). (Pubitemid 44300268)
195. Raineri, I., D. Wegmueller, B. Gross, U. Certa & C. Moroni: Roles of AUF1 isoforms, HuR and BRF1 in AREdependent mRNA turnover studied by RNA interference. Nucleic Acids Research, 32, 1279-88 (2004). (Pubitemid 38854729)
196. Dean, J. L., G. Sully, R. Wait, L. Rawlinson, A. R. Clark & J. Saklatvala: Identification of a novel AU-rich-element-binding protein which is related to AUF1. Biochemical Journal, 366, 709-19. (2002).
197. Lu, K. P. & X. Z. Zhou: The prolyl isomerase PIN1: a pivotal new twist in phosphorylation signalling and disease. Nat Rev Mol Cell Biol, 8, 904-16 (2007). (Pubitemid 47622559)
198. Takahashi, K., C. Uchida, R. W. Shin, K. Shimazaki & T. Uchida: Prolyl isomerase, Pin1: new findings of post-translational modifications and physiological substrates in cancer, asthma and Alzheimer's disease. Cell Mol Life Sci (2007).
199. Esnault, S., Z. J. Shen, E. Whitesel & J. S. Malter: The peptidyl-prolyl isomerase Pin1 regulates granulocyte-macrophage colony-stimulating factor mRNA stability in T lymphocytes. Journal of Immunology, 177, 6999-7006 (2006). (Pubitemid 44715066)
200. Esnault, S. & J. S. Malter: Extracellular signal-regulated kinase mediates granulocyte-macrophage colony-stimulating factor messenger RNA stabilization in tumor necrosis factor-alpha plus fibronectin-activated peripheral blood eosinophils. Blood, 99, 4048-52. (2002). (Pubitemid 35332046)
201. Wilson, G. M., J. Lu, K. Sutphen, Y. Suarez, S. Sinha, B. Brewer, E. C. Villanueva-Feliciano, R. M. Ysla, S. Charles & G. Brewer: Phosphorylation of p40AUF1 regulates binding to A + U-rich mRNA-destabilizing elements and protein-induced changes in ribonucleoprotein structure. Journal of Biological Chemistry, 278, 33039-48 (2003). (Pubitemid 37055749)
202. Wilson, G. M., J. Lu, K. Sutphen, Y. Sun, Y. Huynh & G. Brewer: Regulation of A + U-rich element-directed mRNA turnover involving reversible phosphorylation of AUF1. Journal of Biological Chemistry, 278, 33029-38 (2003). (Pubitemid 37055748)
203. Bollig, F., R. Winzen, M. Gaestel, S. Kostka, K. Resch & H. Holtmann: Affinity purification of ARE-binding proteins identifies poly (A)-binding protein 1 as a potential substrate in MK2-induced mRNA stabilization. Biochemical & Biophysical Research Communications, 301, 665-70. (2003). (Pubitemid 36268942)
204. Shyu, A. B., M. F. Wilkinson & A. van Hoof: Messenger RNA regulation: to translate or to degrade. EMBO Journal, 27, 471-81 (2008). (Pubitemid 351225677)
205. Lodish, H. F., B. Zhou, G. Liu & C. Z. Chen: Micromanagement of the immune system by microRNAs. Nat Rev Immunol, 8, 120-30 (2008). (Pubitemid 351161305)
206. Kato, M. & F. J. Slack: microRNAs: small molecules with big roles - C. elegans to human cancer. Biol Cell, 100, 71- 81 (2008). (Pubitemid 351266765)
207. Filipowicz, W., S. N. Bhattacharyya & N. Sonenberg: Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nat Rev Genet, 9, 102-14 (2008).
208. O'Connell, R. M., K. D. Taganov, M. P. Boldin, G. Cheng & D. Baltimore: MicroRNA-155 is induced during the macrophage inflammatory response. Proceedings of the National Academy of Sciences of the United States of America, 104, 1604-9 (2007). (Pubitemid 46214637)
209. Yin, Q., X. Wang, J. McBride, C. Fewell & E. Flemington: B-cell receptor activation induces BIC/miR-155 expression through a conserved AP-1 element. Journal of Biological Chemistry, 283, 2654-62 (2008).
210. Jing, Q., S. Huang, S. Guth, T. Zarubin, A. Motoyama, J. Chen, F. Di Padova, S. C. Lin, H. Gram & J. Han: Involvement of microRNA in AU-rich element-mediated mRNA instability. Cell, 120, 623-34 (2005). (Pubitemid 40343075)
211. Fukui, N., Y. Ikeda, T. Ohnuki, A. Hikita, S. Tanaka, S. Yamane, R. Suzuki, L. J. Sandell & T. Ochi: Pro-inflammatory cytokine tumor necrosis factor-alpha induces bone morphogenetic protein-2 in chondrocytes via mRNA stabilization and transcriptional up-regulation. Journal of Biological Chemistry, 281, 27229- 41 (2006). (Pubitemid 44401752)
212. Sen, P., P. K. Chakraborty & S. Raha: p38 mitogen-activated protein kinase (p38MAPK) upregulates catalase levels in response to low dose H2O2 treatment through enhancement of mRNA stability. FEBS Letters, 579, 4402-6 (2005). (Pubitemid 41116372)
213. Waterhouse, C. C., R. R. Joseph, G. L. Winsor, T. A. Lacombe & A. W. Stadnyk: Monocyte chemoattractant protein-1 production by intestinal epithelial cells in vitro: a role for p38 in epithelial chemokine expression. Journal of Interferon & Cytokine Research, 21, 223-30. (2001). (Pubitemid 32679510)
214. Xiao, Y. Q., K. Someya, H. Morita, K. Takahashi & K. Ohuchi: Involvement of p38 MAPK and ERK/MAPK pathways in staurosporine-induced production of macrophage inflammatory protein-2 in rat peritoneal neutrophils. Biochimica et Biophysica Acta, 1450, 155- 63 (1999). (Pubitemid 29246015)
215. Wang, S. W., J. Pawlowski, S. T. Wathen, S. D. Kinney, H. S. Lichenstein & C. L. Manthey: Cytokine mRNA decay is accelerated by an inhibitor of p38-mitogen-activated protein kinase. Inflamm Res, 48, 533-8 (1999). (Pubitemid 29495635)
216. Duque, J., M. D. Diaz-Munoz, M. Fresno & M. A. Iniguez: Up-regulation of cyclooxygenase-2 by interleukin-1beta in colon carcinoma cells. Cell Signal, 18, 1262-9 (2006). (Pubitemid 44275220)
217. Gauthier, M. L., C. R. Pickering, C. J. Miller, C. A. Fordyce, K. L. Chew, H. K. Berman & T. D. Tlsty: p38 regulates cyclooxygenase-2 in human mammary epithelial cells and is activated in premalignant tissue. Cancer Research, 65, 1792-9 (2005). (Pubitemid 40478606)
218. Tessner, T. G., F. Muhale, S. Schloemann, S. M. Cohn, A. Morrison & W. F. Stenson: Basic fibroblast growth factor upregulates cyclooxygenase-2 in I407 cells through p38 MAP kinase. Am J Physiol Gastrointest Liver Physiol, 284, G269-79 (2003). (Pubitemid 36120133)
219. Singer, C. A., K. J. Baker, A. McCaffrey, D. P. AuCoin, M. A. Dechert & W. T. Gerthoffer: p38 MAPK and NF-kappaB mediate COX-2 expression in human airway myocytes. Am J Physiol Lung Cell Mol Physiol, 285, L1087-98 (2003). (Pubitemid 37310098)
220. Faour, W. H., A. Mancini, Q. W. He & J. A. Di Battista: T-cell-derived interleukin-17 regulates the level and stability of cyclooxygenase-2 (COX-2) mRNA through restricted activation of the p38 mitogen-activated protein kinase cascade: role of distal sequences in the 3′-untranslated region of COX-2 mRNA. Journal of Biological Chemistry, 278, 26897-907 (2003). (Pubitemid 36876841)
221. Ridley, S. H., J. L. Dean, S. J. Sarsfield, M. Brook, A. R. Clark & J. Saklatvala: A p38 MAP kinase inhibitor regulates stability of interleukin-1-induced cyclooxygenase-2 mRNA. FEBS Letters, 439, 75-80 (1998). (Pubitemid 28537867)
222. Dean, J. L., M. Brook, A. R. Clark & J. Saklatvala: p38 mitogen-activated protein kinase regulates cyclooxygenase-2 mRNA stability and transcription in lipopolysaccharide-treated human monocytes. Journal of Biological Chemistry, 274, 264-9 (1999). (Pubitemid 29035058)
223. Zhang, Z., H. Sheng, J. Shao, R. D. Beauchamp & R. N. DuBois: Post-transcriptional regulation of cyclooxygenase-2 in rat intestinal epithelial cells. Neoplasia, 2, 523-30. (2000). (Pubitemid 32098687)
224. Lasa, M., M. Brook, J. Saklatvala & A. R. Clark: Dexamethasone destabilizes cyclooxygenase 2 mRNA by inhibiting mitogen-activated protein kinase p38. Molecular & Cellular Biology, 21, 771-80. (2001). (Pubitemid 32104726)
225. Bachelor, M. A., A. L. Silvers & G. T. Bowden: The role of p38 in UVA-induced cyclooxygenase-2 expression in the human keratinocyte cell line, HaCaT. Oncogene, 21, 7092-9. (2002). (Pubitemid 35252983)
226. Tran, T., D. J. Fernandes, M. Schuliga, T. Harris, L. Landells & A. G. Stewart: Stimulus-dependent glucocorticoid-resistance of GM-CSF production in human cultured airway smooth muscle. Br J Pharmacol, 145, 123-31 (2005). (Pubitemid 40675556)
227. McCormick, C. & D. Ganem: The kaposin B protein of KSHV activates the p38/MK2 pathway and stabilizes cytokine mRNAs. Science, 307, 739-41 (2005). (Pubitemid 40194646)
228. Tebo, J., S. Der, M. Frevel, K. S. Khabar, B. R. Williams & T. A. Hamilton: Heterogeneity in Control of mRNA Stability by AU Rich Elements. Journal of Biological Chemistry, 28, 28 (2003).
229. Dai, Y., S. Datta, M. Novotny & T. A. Hamilton: TGF{beta} inhibits LPS-induced chemokine mRNA stabilization. Blood, 102, 1178-1185 (2003). (Pubitemid 36988020)
230. Sirenko, O. I., A. K. Lofquist, C. T. DeMaria, J. S. Morris, G. Brewer & J. S. Haskill: Adhesion-dependent regulation of an A+U-rich element-binding activity associated with AUF1. Molecular And Cellular Biology, 17, 3898-906 (1997). (Pubitemid 27281865)
231. Parilla, N. W., V. S. Hughes, K. M. Lierl, H. R. Wong & K. Page: CpG DNA modulates interleukin 1beta-induced interleukin-8 expression in human bronchial epithelial (16HBE14o-) cells. Respir Res, 7, 84 (2006).
232. Henness, S., E. van Thoor, Q. Ge, C. L. Armour, J. M. Hughes & A. J. Ammit: IL-17A acts via p38 MAPK to increase stability of TNF-alpha-induced IL-8 mRNA in human ASM. Am J Physiol Lung Cell Mol Physiol, 290, L1283-90 (2006). (Pubitemid 43830874)
233. Suswam, E. A., L. B. Nabors, Y. Huang, X. Yang & P. H. King: IL-1beta induces stabilization of IL-8 mRNA in malignant breast cancer cells via the 3′ untranslated region: Involvement of divergent RNA-binding factors HuR, KSRP and TIAR. International Journal of Cancer, 113, 911-9 (2005). (Pubitemid 40096870)
234. Ma, P., X. Cui, S. Wang, J. Zhang, E. V. Nishanian, W. Wang, R. A. Wesley & R. L. Danner: Nitric oxide post-transcriptionally up-regulates LPS-induced IL-8 expression through p38 MAPK activation. Journal of Leukocyte Biology, 76, 278-87 (2004). (Pubitemid 38857197)
235. Holtmann, H., J. Enninga, S. Kalble, A. Thiefes, A. Dorrie, M. Broemer, R. Winzen, A. Wilhelm, J. Ninomiya-Tsuji, K. Matsumoto, K. Resch & M. Kracht: The MAPKKK TAK1 plays a central role in coupling the IL-1 receptor to both, transcriptional and RNA-targetted mechanisms of gene regulation. Journal of Biological Chemistry (2000).
236. Jijon, H. B., W. J. Panenka, K. L. Madsen & H. G. Parsons: MAP kinases contribute to IL-8 secretion by intestinal epithelial cells via a post-transcriptional mechanism. Am J Physiol Cell Physiol, 283, C31-41. (2002). (Pubitemid 34670545)
237. Vockerodt, M., D. Pinkert, S. Smola-Hess, A. Michels, R. M. Ransohoff, H. Tesch & D. Kube: The Epstein-Barr virus oncoprotein latent membrane protein 1 induces expression of the chemokine IP-10: importance of mRNA half-life regulation. International Journal of Cancer, 114, 598-605 (2005). (Pubitemid 40349619)
238. Dhillon, N. K., F. Peng, R. M. Ransohoff & S. Buch: PDGF synergistically enhances IFN-gamma-induced expression of CXCL10 in blood-derived macrophages: implications for HIV dementia. Journal of Immunology, 179, 2722-30 (2007).
239. Sun, D. & A. Ding: MyD88-mediated stabilization of interferon-gamma-induced cytokine and chemokine mRNA. Nat Immunol, 7, 375-81 (2006).
240. Wong, H. R., K. E. Dunsmore, K. Page & T. P. Shanley: Heat shock-mediated regulation of MKP-1. Am J Physiol Cell Physiol (2005).
241. Mestas, J., S. P. Crampton, T. Hori & C. C. Hughes: Endothelial cell co-stimulation through OX40 augments and prolongs T cell cytokine synthesis by stabilization of cytokine mRNA. International Immunology, 17, 737-47 (2005). (Pubitemid 41417972)
242. Ming, X. F., G. Stoecklin, M. Lu, R. Looser & C. Moroni: Parallel and independent regulation of interleukin-3 mRNA turnover by phosphatidylinositol 3-kinase and p38 mitogen-activated protein kinase. Molecular & Cellular Biology, 21, 5778-89 (2001). (Pubitemid 32737795)
243. Dodeller, F., A. Skapenko, J. R. Kalden, P. E. Lipsky & H. Schulze-Koops: The p38 mitogen-activated protein kinase regulates effector functions of primary human CD4 T cells. European Journal of Immunology, 35, 3631-42 (2005). (Pubitemid 43025543)
244. Zhao, W., M. Liu & K. L. Kirkwood: p38{alpha} Stabilizes Interleukin-6 mRNA via Multiple AU-rich Elements. Journal of Biological Chemistry, 283, 1778-85 (2008).
245. Hershko, D. D., B. W. Robb, C. J. Wray, G. J. Luo & P. O. Hasselgren: Superinduction of IL-6 by cycloheximide is associated with mRNA stabilization and sustained activation of p38 map kinase and NF-kappaB in cultured caco-2 cells. J Cell Biochem, 91, 951- 61 (2004).
246. Miyazawa, K., A. Mori, H. Miyata, M. Akahane, Y. Ajisawa & H. Okudaira: Regulation of interleukin-1beta-induced interleukin-6 gene expression in human fibroblast-like synoviocytes by p38 mitogen-activated protein kinase. Journal of Biological Chemistry, 273, 24832-8 (1998). (Pubitemid 28454988)
247. Wery-Zennaro, S., J. L. Zugaza, M. Letourneur, J. Bertoglio & J. Pierre: IL-4 regulation of IL-6 production involves Rac/Cdc42- and p38 MAPK-dependent pathways in keratinocytes. Oncogene, 19, 1596-604 (2000). (Pubitemid 30175682)
248. Norata, G. D., C. Banfi, A. Pirillo, E. Tremoli, A. Hamsten, A. L. Catapano & P. Eriksson: Oxidised-HDL3 induces the expression of PAI-1 in human endothelial cells. Role of p38MAPK activation and mRNA stabilization. Br J Haematol, 127, 97-104 (2004). (Pubitemid 39331112)
249. Ehlting, C., W. S. Lai, F. Schaper, E. D. Brenndorfer, R. J. Matthes, P. C. Heinrich, S. Ludwig, P. J. Blackshear, M. Gaestel, D. Haussinger & J. G. Bode: Regulation of suppressor of cytokine signaling 3 (SOCS3) mRNA stability by TNF-alpha involves activation of the MKK6/p38MAPK/MK2 cascade. Journal of Immunology, 178, 2813-26 (2007). (Pubitemid 46333159)
250. Tew, S. R. & T. E. Hardingham: Regulation of SOX9 mRNA in human articular chondrocytes involving p38 MAPK activation and mRNA stabilization. Journal of Biological Chemistry, 281, 39471-9 (2006). (Pubitemid 46041907)
251. Kishore, R., M. R. McMullen & L. E. Nagy: Stabilization of tumor necrosis factor alpha mRNA by chronic ethanol: role of A + U-rich elements and p38 mitogen-activated protein kinase signaling pathway. Journal of Biological Chemistry, 276, 41930-7 (2001).
252. Montero, L. & Y. Nagamine: Regulation by p38 mitogen-activated protein kinase of adenylate- and uridylate-rich element-mediated urokinase-type plasminogen activator (uPA) messenger RNA stability and uPA-dependent in vitro cell invasion. Cancer Research, 59, 5286-93 (1999). (Pubitemid 29503996)
253. Pages, G., E. Berra, J. Milanini, A. P. Levy & J. Pouyssegur: Stress-activated protein kinases (JNK and p38/HOG) are essential for vascular endothelial growth factor mRNA stability. Journal of Biological Chemistry, 275, 26484-91. (2000).
254. Westmark, C. J. & J. S. Malter: Extracellular-regulated kinase controls beta-amyloid precursor protein mRNA decay. Brain Res Mol Brain Res, 90, 193-201 (2001). (Pubitemid 32537640)
255. Headley, V. V., R. Tanveer, S. M. Greene, A. Zweifach & J. D. Port: Reciprocal regulation of beta-adrenergic receptor mRNA stability by mitogen activated protein kinase activation and inhibition. Molecular & Cellular Biochemistry, 258, 109-19 (2004). (Pubitemid 38268205)
256. Tamura, M., S. Sebastian, S. Yang, B. Gurates, Z. Fang & S. E. Bulun: Interleukin-1beta elevates cyclooxygenase-2 protein level and enzyme activity via increasing its mRNA stability in human endometrial stromal cells: an effect mediated by extracellularly regulated kinases 1 and 2. Journal of Clinical Endocrinology & Metabolism, 87, 3263-73 (2002). (Pubitemid 34816375)
257. Xu, K., A. M. Robida & T. J. Murphy: Immediate-early MEK-1 dependent stabilization of rat smooth muscle cell cyclooxygenase-2 mRNA by Gaq-coupled receptor signaling. Journal of Biological Chemistry (2000).
258. Westmark, C. J. & J. S. Malter: Up-regulation of nucleolin mRNA and protein in peripheral blood mononuclear cells by extracellular-regulated kinase. Journal of Biological Chemistry, 276, 1119-26 (2001). (Pubitemid 32096536)
259. Donadelli, M., E. Dalla Pozza, C. Costanzo, M. T. Scupoli, P. Piacentini, A. Scarpa & M. Palmieri: Increased stability of P21 (WAF1/CIP1) mRNA is required for ROS/ERK-dependent pancreatic adenocarcinoma cell growth inhibition by pyrrolidine dithiocarbamate. Biochimica et Biophysica Acta, 1763, 917-26 (2006). (Pubitemid 44332597)
260. Yang, X., W. Wang, J. Fan, A. Lal, D. Yang, H. Cheng & M. Gorospe: Prostaglandin A2-mediated stabilization of p21 mRNA through an ERK-dependent pathway requiring the RNA-binding protein HuR. Journal of Biological Chemistry, 279, 49298-306 (2004). (Pubitemid 39625816)
261. Sullivan, D. E., M. Ferris, D. Pociask & A. R. Brody: Tumor necrosis factor-alpha induces transforming growth factor-beta1 expression in lung fibroblasts through the extracellular signal-regulated kinase pathway. Am J Respir Cell Mol Biol, 32, 342-9 (2005). (Pubitemid 40478310)
262. Ming, X. F., M. Kaiser & C. Moroni: c-jun N-terminal kinase is involved in AUUUA-mediated interleukin-3 mRNA turnover in mast cells. EMBO Journal, 17, 6039-48 (1998). (Pubitemid 28474797)
263. Lahti, A., U. Jalonen, H. Kankaanranta & E. Moilanen: c-Jun NH2-terminal kinase inhibitor anthra (1, 9-cd)pyrazol-6 (2H)-one reduces inducible nitric-oxide synthase expression by destabilizing mRNA in activated macrophages. Molecular Pharmacology, 64, 308-15 (2003). (Pubitemid 36909994)
264. Korhonen, R., K. Linker, A. Pautz, U. Forstermann, E. Moilanen & H. Kleinert: Post-transcriptional regulation of human inducible nitric-oxide synthase expression by the Jun N-terminal kinase. Molecular Pharmacology, 71, 1427-34 (2007). (Pubitemid 46658695)