MEX is a testis-specific E3 ubiquitin ligase that promotes death receptor-induced apoptosis

Biochemical Journal

Volumn 396, Issue 3, 2006, Pages 411-417

  Nishito, Yasumasa ^a   Hasegawa, Mizuho ^a   Inohara, Naohiro ^a   Núñez, Gabriel ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

MEKK1 related protein X (MEX); Really interesting new gene (RING) finger; SWI2 SNF2 and MuDR (SWIM) domain; Testis; Ubiquitination

Indexed keywords

BIOCHEMISTRY; BIODEGRADATION; BIOELECTRIC POTENTIALS; CHEMOTHERAPY; DRUG PRODUCTS; GENE TRANSFER; PROTEINS;

MEKK1-RELATED PROTEIN X (MEX); REALLY INTERESTING NEW GENE (RING) FINGER; SWI2/SNF2 AND MUDR (SWIM) DOMAIN; TESTIS; UBIQUITINATION;

ENZYME KINETICS;

BH3 PROTEIN; DEATH RECEPTOR; FAS ANTIGEN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE 1; PROTEASOME; PROTEIN MEX; UBIQUITIN CONJUGATING ENZYME; UBIQUITIN PROTEIN LIGASE; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN; DEATH RECEPTOR 3; IRON BINDING PROTEIN; NEKK1 RELATED PROTEIN X, MOUSE; NEKK1-RELATED PROTEIN X, MOUSE; TNFRSF10A PROTEIN, HUMAN; TNFRSF25 PROTEIN, HUMAN; TNFRSF25 PROTEIN, MOUSE; TUMOR NECROSIS FACTOR RECEPTOR; UBE2D1 PROTEIN, HUMAN;

AMINO ACID SEQUENCE; APOPTOSIS; ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; NORTHERN BLOTTING; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; TESTIS; UBIQUITINATION; ANIMAL; CHEMISTRY; DRUG EFFECT; ENZYMOLOGY; MALE; METABOLISM; MOLECULAR GENETICS; MOUSE; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; RAT;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD95; APOPTOSIS; HUMANS; IRON-BINDING PROTEINS; MALE; MICE; MOLECULAR SEQUENCE DATA; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN STRUCTURE, TERTIARY; RATS; RECEPTORS, TUMOR NECROSIS FACTOR; RECEPTORS, TUMOR NECROSIS FACTOR, MEMBER 25; TESTIS; UBIQUITIN-CONJUGATING ENZYMES; UBIQUITIN-PROTEIN LIGASES; ZINC FINGERS;

EID: 33744974570     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20051814     Document Type: Article

References (24)

1. Hershko, A. and Ciechanover, A. (1998) The ubiquitin system. Annu. Rev. Biochem. 67, 425-479
2. Coux, O., Tanaka, K. and Goldber, A. L. (1996) Structure and functions of the 20S and 26S proteasomes. Annu. Rev. Biochem. 65, 801-847
3. Voges, D., Zwickl, P. and Baumeister, W. (1999) The 26S proteasome: a molecular machine designed for controlled proteolysis. Annu. Rev. Biochem. 68, 1015-1068
4. Cyr, D. M., Hohfeld, J. and Patterson, C. (2002) Protein quality control: U-box-containing E3 ubiquitin ligases join the fold. Trends Biochem. Sci. 27, 368-375
5. Scheffner, M., Huibregtse, J. M., Vierstra, R. D. and Howley, P. M. (1993) The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53. Cell 75, 495-505
6. Scheffner, M., Nuber, U. and Huibregtse, J. M. (1995) Protein ubiquitination involving an E1-E2-E3 enzyme ubiquitin thioester cascade. Nature (London) 373, 81-83
7. Huibregtse, J. M., Scheffner, M., Beaudenon, S. and Howley, P. M. (1995) A family of proteins structurally and functionally related to the E6-AP ubiquitin-protein ligase. Proc. Natl. Acad. Sci. U.S.A. 92, 2563-2567
8. Freemont, P. S. (1993) The RING finger. A novel protein sequence motif related to the zinc finger. Ann. N. Y. Acad. Sci. 684, 174-192
9. Lorick, K. L., Jensen, J. P., Fang, S., Ong, A. M., Hatakeyama, S. and Weissman, A. M. (1999) RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination. Proc. Natl. Acad. Sci. U.S.A. 96, 11364-11369
10. Freemont, P. S. (2000) Ubiquitination: RING for destruction? Curr. Biol. 10, R84-R87
11. Hu, G., Zhang, S., Vidai, M., Baer, J. L., Xu, T. and Fearon, E. R. (1997) Mammalian homologs of seven in absentia regulate DCC via the ubiquitin-proteasome pathway. Genes Dev. 11, 2701-2714
12. Joazeiro, C. A., Wing, S. S., Huang, H., Leverson, J. D., Hunter, T. and Liu, Y. C. (1999) The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase. Science (Washington, DC) 286, 309-312
13. Kamura, T., Koepp, D. M., Conrad, M. N., Skowyra, D., Moreland, R. J., Iliopoulos, O., Lane, W. S., Kaelin, Jr, W. G., Elledge, S. J., Conaway, R. C. et al. (1999) Rbx1, a component of the VHL tumor suppressor complex and SCF ubiquitin ligase. Science (Washington, DC) 284, 657-661
14. Skowyra, D., Koepp, D. M., Kamura, T., Conrad, M. N., Conaway, R. C., Conaway, J. W., Elledge, S. J. and Harper, J. W. (1999) Reconstitution of G1 cyclin ubiquitination with complexes containing SCFGrr1 and Rbx1. Science (Washington, DC) 284, 662-665
15. Jackson, P. K. and Eldridge, A. G. (2002) The SCF ubiquitin ligase: an extended look. Mol. Cell 9, 923-925
16. Makarova, K. S., Aravind, L. and Koonin, E. V. (2002) SWIM, a novel Zn-chelating domain present in bacteria, archaea and eukaryotes. Trends Biochem. Sci. 27, 384-386
17. Inohara, N., Koseki, T., Chen, S., Wu, X. and Nunez, G. (1998) CIDE, a novel family of cell death activators with homology to the 45 kDa subunit of the DNA fragmentation factor. EMBO J. 274, 2526-2533
18. Inohara, N., Koseki, T., Chen, S., Benedict, M. A. and Nunez, G. (1999) Identification of regulatory and catalytic domains in the apoptosis nuclease DFF40/CAD. J. Biol. Chem. 274, 270-274
19. Inohara, N., Koseki, T., del Peso, L., Hu, Y., Yee, C., Chen, S., Carrio, R., Merino, J., Liu, D., Ni, J. and Nunez, G. (1999) Nod1, an Apaf-1-like activator of caspase-9 and nuclear factor-κB. J. Biol. Chem. 274, 14560-14567
20. Yamaguchi, H. and Wang, H. G. (2002) Bcl-XL protects BimEL-induced Bax conformational change and cytochrome c release independent of interacting with Bax or BimEL. J. Biol. Chem. 277, 41604-41612
21. Kotamraju, S., Kalivendi, S. V., Konorev, E., Chitambar, C. R., Joseph, J. and Kalyanaraman, B. (2004) Oxidant-induced iron signaling in Doxorubicin-mediated apoptosis. Methods Enzymol. 378, 362-382
22. Lu, Z., Xu, S., Joazeiro, C., Cobb, M. H. and Hunter, T. (2002) The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2. Mol. Cell 9, 945-956
23. Grataroli, R., Vindrieux, D., Gougeon, A. and Benahmed, M. (2002) Expression of tumor necrosis factor-a-related apoptosis-inducing ligand and its receptors in rat testis during development. Biol. Reprod. 66, 1707-1715
24. Grataroli, R., Vindrieux, D., Selva, J., Felsenheld, C., Ruffion, A., Decaussin, M. and Benahmed, M. (2004) Characterization of tumour necrosis factor-a-related apoptosis-inducing ligand and its receptors in the adult human testis. Mol. Hum. Reprod. 10, 123-128