MEKK1 binds HECT E3 ligase itch by its amino-terminal RING motif to regulate Th2 cytokine gene expression

Journal of Immunology

Volumn 183, Issue 6, 2009, Pages 3831-3838

  Enzler, Thomas ^a   Chang, Xing ^b   Facchinetti, Valeria ^c   Melino, Gerry ^d   Karin, Michael ^e   Su, Bing ^b   Gallagher, Ewen ^f  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^d UNIVERSITY OF ROME TOR VERGATA   (Italy)

^e San Diego   (United States)

^f IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

HECT E3 LIGASE; LIGASE; MITOGEN ACTIVATED PROTEIN KINASE 7; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE KINASE KINASE 1; RING FINGER PROTEIN; UNCLASSIFIED DRUG; CYTOKINE; ITCH PROTEIN, MOUSE; LYMPHOCYTE ANTIGEN RECEPTOR; UBIQUITIN PROTEIN LIGASE;

AMINO TERMINAL SEQUENCE; ANIMAL EXPERIMENT; ARTICLE; CATALYSIS; CD4+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL ISOLATION; CELL STIMULATION; ENZYME ACTIVATION; GENE EXPRESSION; IMMUNOREGULATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; RNA EXTRACTION; T LYMPHOCYTE ACTIVATION; TH2 CELL; UBIQUITINATION; ANIMAL; BINDING SITE; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOUSE MUTANT; PHOSPHORYLATION; RING FINGER MOTIF;

ANIMALS; BINDING SITES; CYTOKINES; GENE EXPRESSION REGULATION; MAP KINASE KINASE 4; MAP KINASE KINASE KINASE 1; MICE; MICE, KNOCKOUT; PHOSPHORYLATION; PROTEIN BINDING; RECEPTORS, ANTIGEN, T-CELL; RING FINGER DOMAINS; TH2 CELLS; UBIQUITIN-PROTEIN LIGASES;

EID: 70349330009     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0803412     Document Type: Article

References (34)

1. Xia, Y., and M. Karin. 2004. The control of cell motility and epithelial morphogenesis by Jun kinases. Trends Cell. Biol. 14: 94-101. (Pubitemid 38186643)
2. Karin, M., and E. Gallagher. 2005. From JNK to pay dirt: Jun kinases, their biochemistry, physiology and clinical importance. IUBMB Life 57: 283-295. (Pubitemid 40904256)
3. Chen, Z., T. B. Gibson, F. Robinson, L. Silvestro, G. Pearson, B. Xu, A. Wright, C. Vanderbilt, and M. H. Cobb. 2001. MAP kinases. Chem. Rev. 101: 2449-2476.
4. Lange-Carter, C. A., C. M. Pleiman, A. M. Gardner, K. J. Blumer, and G. L. Johnson. 1993. A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf. Science 260: 315-319.
5. Blank, J. L., P. Gerwins, E. M. Elliott, S. Sather, and G. L. Johnson. 1996. Molecular cloning of mitogen-activated protein/ERK kinase kinases (MEKK) 2 and 3: regulation of sequential phosphorylation pathways involving mitogen-activated protein kinase and c-Jun kinase. J. Biol. Chem. 271: 5361-5368.
6. Zhang, L., W. Wang, Y. Hayashi, J. V. Jester, D. E. Birk, M. Gao, C. Y. Liu, W. W. Kao, M. Karin, and Y. Xia. 2003. A role for MEK kinase 1 in TGF-β/activin-induced epithelium movement and embryonic eyelid closure. EMBO J. 22: 4443-4454. (Pubitemid 37087198)
7. Guo, Z., G. Clydesdale, J. Cheng, K. Kim, L. Gan, D. J. McConkey, S. E. Ullrich, Y. Zhuang, and B. Su. 2002. Disruption of Mekk2 in mice reveals an unexpected role for MEKK2 in modulating T-cell receptor signal transduction. Mol. Cell. Biol. 22: 5761-5768.
8. Deng, M., W. L. Chen, A. Takatori, Z. Peng, L. Zhang, M. Mongan, R. Parthasarathy, M. Sartor, M. Miller, J. Yang, et al. 2006. A role for the mitogen-activated protein kinase kinase kinase 1 in epithelial wound healing. Mol. Biol. Cell 17: 3446-3455.
9. Gao, M., T. Labuda, Y. Xia, E. Gallagher, D. Fang, Y. C. Liu, and M. Karin. 2004. Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch. Science 306: 271-275. (Pubitemid 39336871)
10. Gallagher, E., T. Enzler, A. Matsuzawa, A. Anzelon-Mills, D. Otero, R. Holzer, E. Janssen, M. Gao, and M. Karin. 2007. Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production. Nat. Immunol. 8: 57-63. (Pubitemid 46242359)
11. Fang, D., C. Elly, B. Gao, N. Fang, Y. Altman, C. Joazeiro, T. Hunter, N. Copeland, N. Jenkins, and Y. C. Liu. 2002. Dysregulation of T lymphocyte function in itchy mice: a role for Itch in Th2 differentiation. Nat. Immunol. 3: 281-287. (Pubitemid 34213430)
12. Cantrell, D. 1996. T cell antigen receptor signal transduction pathways. Annu. Rev. Immunol. 14: 259-274. (Pubitemid 26130185)
13. Dong, C., D. D. Yang, M. Wysk, A. J. Whitmarsh, R. J. Davis, and R. A. Flavell. 1998. Defective T cell differentiation in the absence of Jnk1. Science 282: 2092-2095. (Pubitemid 29001267)
14. + T cells to Th1 cells requires MAP kinase JNK2. Immunity 9: 575-585.
15. + T cell activation. J. Exp. Med. 195: 811-823.
16. Li, B., C. Tournier, R. J. Davis, and R. A. Flavell. 1999. Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation. EMBO J. 18: 420-432. (Pubitemid 29041950)
17. Hartenstein, B., S. Teurich, J. Hess, J. Schenkel, M. Schorpp-Kistner, and P. Angel. 2002. Th2 cell-specific cytokine expression and allergen-induced airway inflammation depend on JunB. EMBO J. 21: 6321-6329. (Pubitemid 35448410)
18. Olsen, J. V., B. Blagoev, F. Gnad, B. Macek, C. Kumar, P. Mortensen, and M. Mann. 2006. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. Cell 127: 635-648.
19. Gallagher, E., M. Gao, Y. C. Liu, and M. Karin. 2006. Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change. Proc. Natl. Acad. Sci. USA 103: 1717-1722. (Pubitemid 43228759)
20. Aguado, E., S. Richelme, S. Nunez-Cruz, A. Miazek, A. M. Mura, M. Richelme, X. J. Guo, D. Sainty, H. T. He, B. Malissen, and M. Malissen. 2002. Induction of T helper type 2 immunity by a point mutation in the LAT adaptor. Science 296: 2036-2040. (Pubitemid 34627528)
21. Gallagher, E. D., S. Xu, C. Moomaw, C. A. Slaughter, and M. H. Cobb. 2002. Binding of JNK/SAPK to MEKK1 is regulated by phosphorylation. J. Biol. Chem. 277: 45785-45792.
22. Ketteler, R., S. Glaser, O. Sandra, U. M. Martens, and U. Klingmuller. 2002. Enhanced transgene expression in primitive hematopoietic progenitor cells and embryonic stem cells efficiently transduced by optimized retroviral hybrid vectors. Gene Ther. 9: 477-487.
23. Sun, W., X. Wei, K. Kesavan, T. P. Garrington, R. Fan, J. Mei, S. M. Anderson, E. W. Gelfand, and G. L. Johnson. 2003. MEK kinase 2 and the adaptor protein Lad regulate extracellular signal-regulated kinase 5 activation by epidermal growth factor via Src. Mol. Cell. Biol. 23: 2298-2308.
24. Kesavan, K., K. Lobel-Rice, W. Sun, R. Lapadat, S. Webb, G. L. Johnson, and T. P. Garrington. 2004. MEKK2 regulates the coordinate activation of ERK5 and JNK in response to FGF-2 in fibroblasts. J. Cell Physiol. 199: 140-148.
25. Mowen, K. A., and L. H. Glimcher. 2004. Signaling pathways in Th2 development. Immunol. Rev. 202: 203-222.
26. Matsuzawa, A., P. H. Tseng, S. Vallabhapurapu, J. L. Luo, W. Zhang, H. Wang, D. A. Vignali, E. Gallagher, and M. Karin. 2008. Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex. Science 321: 548-549.
27. Xia, Y., Z. Wu, B. Su, B. Murray, and M. Karin. 1998. JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension. Genes Dev. 12: 3369-3381.
28. Su, B., J. Cheng, J. Yang, and Z. Guo. 2001. MEKK2 is required for T-cell receptor signals in JNK activation and interleukin-2 gene expression. J. Biol. Chem. 276: 14784-14790.
29. Wan, Y. Y., H. Chi, M. Xie, M. D. Schneider, and R. A. Flavell. 2006. The kinase TAK1 integrates antigen and cytokine receptor signaling for T cell development, survival and function. Nat. Immunol. 7: 851-858.
30. Liu, H. H., M. Xie, M. D. Schneider, and Z. J. Chen. 2006. Essential role of TAK1 in thymocyte development and activation. Proc. Natl. Acad. Sci. USA 103: 11677-11682.
31. Blonska, M., B. P. Pappu, R. Matsumoto, H. Li, B. Su, D. Wang, and X. Lin. 2007. The CARMA1-Bcl10 signaling complex selectively regulates JNK2 kinase in the T cell receptor-signaling pathway. Immunity 26: 55-66.
32. Burack, W. R., A. M. Cheng, and A. S. Shaw. 2002. Scaffolds, adaptors and linkers of TCR signaling: theory and practice. Curr. Opin. Immunol. 14: 312-316.
33. Morrison, D. K., and R. J. Davis. 2003. Regulation of MAP kinase signaling modules by scaffold proteins in mammals. Annu. Rev. Cell. Dev. Biol. 19: 91-118.
34. Shembade, N., N. S. Harhaj, K. Parvatiyar, N. G. Copeland, N. A. Jenkins, L. E. Matesic, and E. W. Harhaj. 2008. The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20. Nat. Immunol. 9: 254-262. (Pubitemid 351276830)