Tpl-2 is an oncogenic kinase that is activated by carboxy-terminal truncation

Genes and Development

Volumn 11, Issue 6, 1997, Pages 688-700

  Ceci, Jeffrey D ^a,d   Patriotis, Christos P ^b   Tsatsanis, Christos ^b   Makris, Antonios M ^b,e   Kovatch, Robert ^c   Swing, Deborah A ^a   Jenkins, Nancy A ^a   Tsichlis, Philip N ^b   Copeland, Neal G ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b FOX CHASE CANCER CENTER   (United States)

^c CHARLES RIVER LABORATORIES   (United States)

^d University of Texas Medical Branch School of Medicine   (United States)

^e MEDITERRANEAN AGRONOMIC INSTITUTE OF CHANIA   (Greece)

Author keywords

MAPK; oncogenesis; protein kinase; SAPK; Tpl 2 Cot proto oncogene; transgenic mice

Indexed keywords

GLUTATHIONE TRANSFERASE; HYBRID PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; ENZYME ACTIVATION; ENZYME STRUCTURE; GENE EXPRESSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTO ONCOGENE; STRUCTURE ACTIVITY RELATION; T CELL LYMPHOMA; TRANSGENIC MOUSE;

ANIMALIA; MUS MUSCULUS; TRIXIS; UNIDENTIFIED RETROVIRUS;

EID: 0030902506     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.11.6.688     Document Type: Article

References (46)

1. Abraham, K.M., S.D. Levin, J.D. Marth, K.A. Forbush, and R.M. Perlmutter. 1991a. Thymic tumorigenesis induced by overexpression of p561ck. Proc. Natl. Acad. Sci. 88: 3977-3981.
2. Abraham, K.M., S.D. Levin, J.D. Marth, K.A. Forbush, and R.M. Perlmutter. 1991b. Delayed thymocyte development induced by augmented expression of p561ck. J. Exp. Med. 173: 1421-1432.
3. Anderson, S., D. Davis, H. Dahlback, H. Jornvall, and D.W. Russell. 1989. Cloning, structure, and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme. J. Biol. Chem. 264: 8222-8229.
4. Bear, S.E., A. Bellacosa, P.A. Lazo, N.A. Jenkins, N.G. Copeland, C. Hanson, G. Levan, and P.N. Tsichlis. 1989. Provirus insertion in Tpl-1, an Ets-1 related oncogene, is associated with tumor progression in MoMuLV induced rat thymic lymphomas. Proc. Natl. Acad. Sci. 86: 7495-7499.
5. Bellacosa, A., J. Testa, S. Staal, and P.N. Tsichlis. 1991. A retroviral oncogene, Akt, encoding a serine-threonine kinase containing an SH2-like region. Science 254: 274-277.
6. Bierer, B.E., B.P. Sleckman, S.E. Ratnofsky, and S.J. Burakoff. 1989. The biologic roles of CD2, CD4, and CD8 in T-cell activation. Annu. Rev. Immunol. 7: 579-599.
7. Blair, D.G., M.K. Oskarsson, A. Seth, K.J. Dunn, M. Dean, M. Zweig, M.A. Tainsky, and G.F. Vande Woude. 1986. Analysis of the transforming potential of the human homolog of mos. Cell 46: 785-794.
8. Bonner, T.I., H. Oppermann, P. Seeburg, S.B. Kerby, M.A. Gunnell, A.C. Young, and U.R. Rapp. 1986. The complete coding sequence of the human rat oncogene and the corresponding structure of the c-raf-1 gene. Nucleic Acids Res. 14: 1009-1015.
9. Ceci, J.D., L.D. Siracusa, N.A. Jenkins, and N.G. Copeland. 1989. A molecular genetic linkage map of mouse chromosome 4 including the localization of several proto-oncogenes. Genomics 5: 699-709.
10. Ceci, J.D., D.M. Kingsley, C.M. Silan, N.G. Copeland, and N.A. Jenkins. 1990. An interspecific backcross linkage map of the proximal half of mouse chromosome 14. Genomics 6: 673-678.
11. Ceci, J.D., R.M. Kovatch, D.A. Swing, I.M. Jones, C.M. Snow, M.P. Rosenberg, N.A. Jenkins, N.G. Copeland, and M.H. Meisler. 1991. Transgenic mice carrying a murine amylase 2.2/SV40 fusion gene develop pancreatic acinar cell and stomach carcinomas. Oncogene 6: 323-332.
12. Coffman, B. 1982. Surface antigen expression and immunoglobulin rearrangement during mouse pre-B cell development. Immunol. Rev. 69: 5-23.
13. Datta, K., A. Bellacosa, T.O. Chan, and P.N. Tsichlis. 1996. Akt is a direct target of the phosphatidylinositol 3-kinase. Activation by growth factors, v-src and v-Ha-ras, in Sf9 and mammalian cells. J. Biol. Chem. 271: 30835-30839.
14. De Bondt, H.L., J. Rosenblatt, J. Jancarik, H.D. Jones, D.O. Morgan, and S.H. Kim. 1993. Crystal structure of cyclin-dependent kinase 2. Nature 363: 595-602.
15. Durand, D.B., J.P. Shaw, M.R. Bush, R.E. Replogle, R. Belagaje, and G.R. Crabtree. 1988. Characterization of antigen receptor response elements within the interleukin-2 enhancer. Mol. Cell. Biol. 8: 1715-1724.
16. Evan, G.I., G.K. Lewis, G. Ramsay, and J.M. Bishop. 1985. Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product. Mol. Cell. Biol. 5: 3610-3616.
17. Fleming, T.J., M.L. Fleming, and T.R. Malek. 1993. Selective expression of Ly-6G on myeloid lineage cells in mouse bone marrow. RB6-8C5 mAb to granulocyte-differentiation antigen (Gr-1) detects members of the Ly-6 family. J. Immunol. 151: 2399-2408.
18. Flint, A.J., R.D. Paladini, and D.E. Koshland, Jr. 1990. Autophosphorylation of protein kinase C at three separated regions of its primary sequence. Science 249: 408-411.
19. Gilbert, D.J., P.E. Neumann, B.A. Taylor, N.A. Jenkins, and N.G. Copeland. 1993. Susceptibility of AKXD recombinant inbred mouse strains to lymphomas. J. Virol. 67: 2083-2090.
20. Han, J.-W., R.B. Pearson, P.B. Dennis, and G. Thomas. 1995. Rapamycin, wortmannin, and the methylxanthine SQ20006 inactivate p70s6k by inducing dephosphorylation of the same subset of sites. J. Biol. Chem. 270: 21396-21403.
21. Hardy, R.R., C.E. Carmack, S.A. Shinton, J.D. Kemp, and K. Hayakawa. 1991. Resolution and characterization of Pro-B and Pre-Pro-B cell stages in normal mouse bone marrow. J. Exp. Med. 173: 1213-1225.
22. Janeway, C.A., Jr. 1992. The T cell receptor as a multicomponent signalling machine: CD4/CD8 coreceptors and CD45 in T cell activation. Annu. Rev. Immunol. 10: 645-674.
23. Jenkins, N.A., N.G. Copeland, B.A. Taylor, and B.K. Lee. 1982. Organization, distribution, and stability of endogenous ecotropic murine leukemia virus DNA sequences in chromosomes of Mus musculus. J. Virol. 43: 26-36.
24. Koch, C.A., D. Anderson, M.F. Moran, C. Ellis, and T. Pawson. 1991. SH2 and SH3 domains: Elements that control interactions of cytoplasmic signaling proteins. Science 252: 668-674.
25. Lazo, P.A., A.J.P. Klein-Szanto, and P.N. Tsichlis. 1990. T cell lymphoma lines derived from rat thymomas induced by Moloney murine leukemia virus: Phenotypic diversity and its implications. J. Virol. 64: 3948-3959.
26. Ledbetter, J.A., R.V. Rouse, H.S. Micklem, and L.A. Herzenberg. 1980. T cell subsets defined by expression of Lyt-1,2,3 and Thy-1 antigens. Two-parameter immunofluorescence and cytotoxicity analysis with monoclonal antibodies modifies current views. J. Exp. Med. 152: 280-295.
27. Madhusudan, E.A. Trafny, N.H. Xuong, J.A. Adams, L.F. Ten Eyck, S.S. Taylor, and J.M. Sowadski. 1994. cAMP-dependent protein kinase: Crystallographic insights into substrate recognition and phosphotransfer. Protein Sci. 3: 176-187.
28. Makris, A., C. Patriotis, S.E. Bear, and P.N. Tsichlis. 1993. Genomic organization and expression of Tpl-2 in normal cells and Moloney murine leukemia virus-induced rat T-cell lymphomas: Activation by provirus insertion. J. Virol. 67: 4283-4289.
29. McCutchan, J.H. and S.J. Pagano. 1968. Enhancement of the infectivity of simian virus 40 deoxyribonucleic acid with diethylaminoethyl-dextran. J. Natl. Cancer Inst. 41: 351-357.
30. Miyoshi, J., T. Higashi, H. Mukai, T. Ohuchi, and T. Kakunaga. 1991. Structure and transforming potential of the human cot oncogene encoding a putative protein kinase. Mol. Cell. Biol. 11: 4088-4096.
31. Morgan, D.O. and H.L. De Bondt. 1994. Protein kinase regulation: Insights from crystal structure analysis. Curr. Opin. Cell Biol. 6: 239-246.
32. Morrison, D.K., G. Heidecker, U.R. Rapp, and T.D. Copeland. 1993. Identification of the major phosphorylation sites of the Raf-1 kinase. J. Biol. Chem. 268: 17309-17316.
33. Mucenski, M.L., B.A. Taylor, N.A. Jenkins, and N.G. Copeland. 1986. AKxD recombinant inbred strains: Models for studying the molecular genetic basis of murine lymphomas. Mol. Cell. Biol. 6: 4236-4243.
34. Muise, H.R. and N. Rosen. 1995. Identification of a novel repressive element in the proximal lck promoter. J. Biol. Chem. 270: 27538-27543.
35. Osborn, L., M.P. Rosenberg, S.A. Keller, and M.H. Meisler. 1987. Tissues specific and insulin dependent expression of a pancreatic amylase gene in transgenic mice. Mol. Cell. Biol. 7: 326-334.
36. Patriotis, C., A. Makris, S.E. Bear, and P.N. Tsichlis. 1993. Tumor progression locus-2 (Tpl-2) encodes a protein kinase involved in the progression of rodent T cell lymphomas and in T cell activation. Proc. Natl. Acad. Sci. 90: 2251-2255.
37. Patriotis, C., A. Makris, J. Chernoff, and P.N. Tsichlis. 1994. Tpl-2 acts in concert with Ras and Raf-1 to activate the MAP kinase. Proc. Natl. Acad. Sci. 91: 9755-9759.
38. Salmerón, A., T.B. Ahmad, G.W. Carlile, D. Pappin, R.P. Narsimhan, and S.C. Ley. 1996. Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase. EMBO J. 15: 817-826.
39. Schlossman, S., L. Boumsell, W. Gilks, J.M. Harlan, T. Kishimoto, C. Morimoto, J. Ritz, S. Shaw, R.L. Silverstein, T.A. Springer et al. 1995. Leucocyte typing V: White cell differentiation antigens. Oxford University Press, New York, NY.
40. Siracusa, L.D., L.B. Russell, N.A. Jenkins, and N.G. Copeland. 1987. Allelic variation within the Emv-15 locus defines genomic sequences closely linked to the agouti locus on mouse chromosome 2. Genetics 117: 85-92.
41. Springer, T., G. Galfré, D.S. Secher, and C. Milstein. 1979. Mac-1: A macrophage differentiation antigen identified by monoclonal antibody. Eur. J. Immunol. 9: 301-306.
42. Taylor, S.S., D.R. Knighton, J. Zheng, J.M. Sowadski, C.S. Gibbs, and M.J. Zoller. 1993. A template for the protein kinase family. Trends Biochem. Sci. 18: 84-89.
43. Tsichlis, P.N., A. Makris, C. Patriotis, C.B. Gilks, A. Bellacosa, and S.E. Bear. 1994. Progression of retrovirus induced rodent T cell lymphomas, and regulation of T cell growth: An insertional mutagenesis based genetic strategy. In Proceedings of the 128th Meeting of the Society for General Microbiology, University of Cambridge, 28th-31st March 1994, Main Symposium: Viruses and Cancer (ed. A. Minson, J. Neil, and M. McCrae), Vol. 51, pp. 247-264. Cambridge University Press, Cambridge, UK.
44. van Lohuizen, M., S. Verbeek, P. Krimpenfort, J. Domen, C. Saris, T. Radaszkiewicz, and A. Berns. 1989. Predisposition to lymphomagenesis in pim-1 transgenic mice: Cooperation with c-myc and N-myc in murine leukemia virus-induced tumors. Cell 56: 673-682.
45. Wildin, R.S., A.M. Garvin, S. Pawar, D.B. Lewis, K.M. Abraham, K.A. Forbush, S.F. Ziegler, J.M. Allen, and R.M. Perlmutter. 1991. Developmental regulation of lck gene expression in T lymphocytes. J. Exp. Med. 173: 383-393.
46. Yeatman, T.J. and G.L. Nicolson. 1993. Molecular basis of tumor progression: Mechanisms of organ-specific tumor metastasis. Semin. Surg. Oncol. 9: 256-263.