Acquisition of sensitivity of stress-activated protein kinases to the p38 inhibitor, SB 203580, by alteration of one or more amino acids within the ATP binding pocket

Journal of Biological Chemistry

Volumn 273, Issue 25, 1998, Pages 15605-15610

  Gum, Rebecca J ^a   McLaughlin, Megan M ^a   Kumar, Sanjay ^a   Wang, Zhulun ^b   Bower, Michael J ^a   Lee, John C ^a   Adams, Jerry L ^a   Livi, George P ^a   Goldsmith, Elizabeth J ^b   Young, Peter R ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ADENOSINE TRIPHOSPHATE; MITOGEN ACTIVATED PROTEIN KINASE;

ARTICLE; BINDING AFFINITY; DRUG PROTEIN BINDING; ENZYME ACTIVATION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; STRESS; YEAST;

ADENOSINE TRIPHOSPHATE; AMINO ACID SUBSTITUTION; BINDING SITES; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HELA CELLS; HISTIDINE; HUMANS; IMIDAZOLES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; METHIONINE; MITOGEN-ACTIVATED PROTEIN KINASE 12; MITOGEN-ACTIVATED PROTEIN KINASE 13; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN CONFORMATION; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; THREONINE;

EID: 10744227768     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.25.15605     Document Type: Article

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