The Mnks: MAP kinase-interacting kinases (MAP kinase signal-integrating kinases)

Frontiers in Bioscience

Volumn 13, Issue 14, 2008, Pages 5359-5374

  Buxade, Maria ^a   Parra Palau, Josep L ^b   Proud, Christopher G ^c  

^a UNIVERSITAT POMPEU FABRA   (Spain)

^b HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Apoptosis; Cytokine; Initiation factor; MAP Kinase; Mnk; mRNA Translation; Review

Indexed keywords

EUKARYOTA;

DROSOPHILA PROTEIN; INITIATION FACTOR 4E; MKNK1 PROTEIN, HUMAN; MKNK2 PROTEIN, HUMAN; PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE; SIGNAL PEPTIDE;

ALTERNATIVE RNA SPLICING; ANIMAL; CELL SURVIVAL; DROSOPHILA; ENZYMOLOGY; GENETIC VARIABILITY; GENETICS; HUMAN; METABOLISM; NEOPLASM; PATHOLOGY; PHOSPHORYLATION; REVIEW;

ALTERNATIVE SPLICING; ANIMALS; CELL SURVIVAL; DROSOPHILA; DROSOPHILA PROTEINS; EUKARYOTIC INITIATION FACTOR-4E; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NEOPLASMS; PHOSPHORYLATION; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; VARIATION (GENETICS);

EID: 52049088725     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/3086     Document Type: Article

References (94)

1. Fukunaga R, and T. Hunter: Mnk1, a new MAP kinaseactivated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates. EMBO J 16, 1921-1933 (1997) (Pubitemid 27170953)
2. Waskiewicz A. J, A. Flynn, C. G. Proud and J. A. Cooper: Mitogen-activated kinases activate the serine/threonine kinases Mnk1 and Mnk2. EMBO J 16, 1909-1920 (1997) (Pubitemid 27170952)
3. Wang X, A. Flynn, A. J. Waskiewicz, B. L. J. Webb, R. G. Vries, I. A. Baines, J. Cooper and C. G. Proud: The phosphorylation of eukaryotic initiation factor eIF4E in response to phorbol esters, cell stresses and cytokines is mediated by distinct MAP kinase pathways. J Biol Chem 273, 9373-9377 (1998) (Pubitemid 28183016)
4. Waskiewicz A. J, J. C. Johnson, B. Penn, M. Mahalingam, S. R. Kimball and J. A. Cooper: Phosphorylation of the cap-binding protein eukaryotic translation factor 4E by protein kinase Mnk1 in vivo. Mol Cell Biol 19, 1871-1880 (1999) (Pubitemid 29098245)
5. Ueda T, R. Watanabe-Fukunaga, H. Fukuyama, S. Nagata and R. Fukunaga: Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development. Mol Cell Biol 24, 6539-6549 (2004) (Pubitemid 38944335)
6. Roux P. P. and J. Blenis: ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions. Microbiol Mol Biol Rev 68, 320-344 (2004) (Pubitemid 38756868)
7. Slentz-Kesler K, J. T. Moore, M. Lombard, J. Zhang, R. Hollingsworth and M. P. Weiner: Identification of the human Mnk2 gene (MKNK2) through protein interaction with estrogen receptor β. Genomics 69, 63-71 (2000)
8. Orton K. C, J. Ling, A. J. Waskiewicz, J. A. Cooper, W. C. Merrick, N. L. Korneeva, R. E. Rhoads, N. Sonenberg and J. A. Traugh: Phosphorylation of Mnk1 by caspaseactivated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk. J Biol Chem 279, 38649-38657 (2004) (Pubitemid 39296021)
9. Bardwell A. J, M. Abdollahi and L. Bardwell: Docking sites on mitogen-activated protein kinase (MAPK) kinases, MAPK phosphatases and the Elk-1 transcription factor compete for MAPK binding and are crucial for enzymic activity. Biochem J 370, 1077-1085 (2003) (Pubitemid 36399103)
10. Sharrocks A. D, S. H. Yang and A. Galanis: Docking domains and substrate-specificity determination for MAP kinases. Trends Biochem Sci. 25, 448-453 (2000) (Pubitemid 30662413)
11. Tanoue T, M. Adachi, T. Moriguchi and E. Nishida: A conserved docking motif in MAP kinases common to substrates, activators and regulators. Nat Cell Biol 2, 110-116 (2000)
12. MacKenzie S. J, G. S. Baillie, I. McPhee, G. B. Bolger and M. D. Houslay: ERK2 mitogen-activated protein kinase binding, phosphorylation, and regulation of the PDE4D cAMP-specific phosphodiesterases. The involvement of COOH-terminal docking sites and NH2-terminal UCR regions. J Biol Chem 275, 16609-16617 (2000) (Pubitemid 30398887)
13. O'Loghlen A, V. M. Gonzalez, D. Pineiro, M. I. Perez-Morgado, M. Salinas and M. E. Martin: Identification and molecular characterization of Mnk1b, a splice variant of human MAP kinase-interacting kinase Mnk1. Exp Cell Res. 299, 343-355 (2004) (Pubitemid 39179802)
14. Pyronnet S, H. Imataka, A. C. Gingras, R. Fukunaga, T. Hunter and N. Sonenberg: Human eukaryotic translation initiation factor 4G (eIF4G) recruits Mnk1 to phosphorylate eIF4E. EMBO J 18, 270-279 (1999) (Pubitemid 29005042)
15. Parra-Palau J. L, G. C. Scheper, M. L. Wilson and C. G. Proud: Features in the N and C termini of the MAPKinteracting kinase Mnk1 mediate its nucleocytoplasmic shuttling. J Biol Chem 278, 44197-44204 (2003) (Pubitemid 37377163)
16. Scheper G. C, J.-L. Parra, M. L. Wilson, B. van Kollenburg, A. C. O. Vertegaal, Z.-G. Han and C. G. Proud: The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization. Mol Cell Biol 23, 5692-5705 (2003) (Pubitemid 36951333)
17. Scheper G. C, N. A. Morrice, M. Kleijn and C. G. Proud: The MAP kinase signal-integrating kinase Mnk2 is an eIF4E kinase with high basal activity in mammalian cells. Mol Cell Biol 21, 743-754 (2001)
18. O'Loghlen A, V. M. Gonzalez, T. Jurado, M. Salinas and M. E. Martin: Characterization of the activity of human MAP kinase-interacting kinase Mnk1b. Biochim Biophys Acta 2007)
19. Zhao Z, Z. Tan, C. D. Diltz, M. You and E. H. Fischer: Activation of mitogen-activated protein (MAP) kinase pathway by pervanadate, a potent inhibitor of tyrosine phosphatases. J Biol Chem 271, 22251-22255 (1996) (Pubitemid 26303861)
20. Parra J. L, M. Buxade and C. G. Proud: Features of the catalytic domains and C termini of the MAPK signal-integrating kinases Mnk1 and Mnk2 determine their differing activities and regulatory properties. J Biol Chem 280, 37623-37633 (2005) (Pubitemid 41642371)
21. Jauch R, S. Jakel, C. Netter, K. Schreiter, B. Aicher, H. Jackle and M. C. Wahl: Crystal structures of the Mnk2 kinase domain reveal an inhibitory conformation and a zinc binding site. Structure 13, 1559-1568 (2005) (Pubitemid 41427594)
22. Jauch R, M. K. Cho, S. Jakel, C. Netter, K. Schreiter, B. Aicher, M. Zweckstetter, H. Jackle and M. C. Wahl: Mitogen-activated protein kinases interacting kinases are autoinhibited by a reprogrammed activation segment. EMBO J 25, 4020-4032 (2006) (Pubitemid 44338744)
23. Fabian M. A, W. H. Biggs, III, D. K. Treiber, C. E. Atteridge, M. D. Azimioara, M. G. Benedetti, T. A. Carter, P. Ciceri, P. T. Edeen, M. Floyd, J. M. Ford, M. Galvin, J. L. Gerlach, R. M. Grotzfeld, S. Herrgard, D. E. Insko, M. A. Insko, A. G. Lai, J. M. Lelias, S. A. Mehta, Z. V. Milanov, A. M. Velasco, L. M. Wodicka, H. K. Patel, P. P. Zarrinkar and D. J. Lockhart: A small molecule-kinase interaction map for clinical kinase inhibitors. Nat Biotechnol 23, 329-336 (2005) (Pubitemid 41094421)
24. Buxade M, J. L. Parra, S. Rousseau, N. Shpiro, R. Marquez, N. Morrice, J. Bain, E. Espel and C. G. Proud: The Mnks Are Novel Components in the Control of TNFalpha Biosynthesis and Phosphorylate and Regulate hnRNP A1. Immunity 23, 177-189 (2005) (Pubitemid 41169287)
25. Guil S, J. C. Long and J. F. Caceres: hnRNP A1 relocalization to the stress granules reflects a role in the stress response. Mol Cell Biol 26, 5744-5758 (2006) (Pubitemid 44134331)
26. Buxade M, N. Morrice, D. L. Krebs and C. G. Proud: The PSF/p54nrb complex is a novel Mnk substrate that binds the mRNA for TNFalpha. J Biol Chem 283, 57-65 (2007)
27. Hefner Y, A. G. Borsch-Haubold, M. Murakami, J. I. Wilde, S. Pasquet, D. Schieltz, F. Ghomashchi, J. R. Yates, III, C. G. Armstrong, A. Paterson, P. Cohen, R. Fukunaga, T. Hunter, I. Kudo, S. P. Watson and M. H. Gelb: Serine 727 phosphorylation and activation of cytosolic phospholipase A2 by MNK1-related protein kinases. J Biol Chem 275, 37542-37551 (2000) (Pubitemid 32004863)
28. Dasilva J, L. Xu, H. J. Kim, W. T. Miller and D. Bar-Sagi: Regulation of sprouty stability by mnk1-dependent phosphorylation. Mol Cell Biol 26, 1898-1907 (2006)
29. Scheper G. C. and C. G. Proud: Does phosphorylation of the cap-binding protein eIF4E play a role in translation initiation? Eur J Biochem 269, 5350-5359 (2002) (Pubitemid 35365524)
30. Knauf U, C. Tschopp and H. Gram: Negative regulation of protein translation by mitogen-activated protein kinaseinteracting kinases 1 and 2. Mol Cell Biol 21, 5500-5511 (2001) (Pubitemid 32702454)
31. Tschopp C, U. Knauf, M. Brauchle, M. Zurini, P. Ramage, D. Glueck, L. New, J. Han and H. Gram: Phosphorylation of eIF-4E on Ser 209 in response to mitogenic and inflammatory stimuli is faithfully detected by specific antibodies. Mol Cell Biol Res Commun 3, 205-211 (2000) (Pubitemid 30602025)
32. Carroll M, O. Warren, X. Fan and W. S. Sossin: 5-HT stimulates eEF2 dephosphorylation in a rapamycinsensitive manner in Aplysia neurites. J Neurochem 90, 1464-1476 (2004) (Pubitemid 39223649)
33. Ross G, J. R. Dyer, V. F. Castellucci and W. S. Sossin: Mnk is a negative regulator of cap-dependent translation in Aplysia neurons. J Neurochem 97, 79-91 (2006)
34. Scheper G. C, B. van Kollenburg, J. Hu, Y. Luo, D. J. Goss and C. G. Proud: Phosphorylation of eukaryotic initiation factor 4E markedly reduces its affinity for capped mRNA. J Biol Chem 277, 3303-3309 (2002) (Pubitemid 34953196)
35. Morley S. J. and S. Naegele: Phosphorylation of eukaryotic initiation factor (eIF) 4E is not required for de novo protein synthesis following recovery from hypertonic stress in human kidney cells. J Biol Chem 277, 32855-32859 (2002) (Pubitemid 34984797)
36. Walsh D. and I. Mohr: Phosphorylation of eIF4E by Mnk-1 enhances HSV-1 translation and replication in quiescent cells. Genes Dev 18, 660-672 (2004) (Pubitemid 38489934)
37. Walsh D, C. Perez, J. Notary and I. Mohr: Regulation of the translation initiation factor eIF4F by multiple mechanisms in human cytomegalovirus-infected cells. J Virol 79, 8057-8064 (2005) (Pubitemid 40853509)
38. Bain J, L. Plater, M. Elliott, N. Shpiro, C. J. Hastie, H. McLauchlan, I. Klevernic, J. S. Arthur, D. R. Alessi and P. Cohen: The selectivity of protein kinase inhibitors: a further update. Biochem J 408, 297-315 (2007)
39. Wang X, P. Yue, C. B. Chan, K. Ye, T. Ueda, R. Watanabe-Fukunaga, R. Fukunaga, H. Fu, F. R. Khuri and S. Y. Sun: Inhibition of mammalian target of rapamycin induces phosphatidylinositol 3-kinase-dependent and Mnkmediated eukaryotic translation initiation factor 4E phosphorylation. Mol Cell Biol 27, 7405-7413 (2007) (Pubitemid 350033648)
40. Sachs A. (2000) Physical and functional interactions between the mRNA cap structure and the poly (A) tail. In Translational control of gene expression (Sonenberg, N, Hershey, J.W.B. and Mathews, M.B. Eds.), pp. 447-465. Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
41. PestovaT.V, Lorsch, J.R. and Hellen, C.U.T. (2006) The mechanism of translation initiation in eukaryotes. In Translational Control in Biology and Medicine (Mathews, M.B, Sonenberg, N. and Hershey, J.W.B. Eds.), pp. 87-128. Cold Spring Harbor Laboratory Press.
42. Barreau C, L. Paillard and H. B. Osborne: AU-rich elements and associated factors: are there unifying principles? Nucleic Acids Res 33, 7138-7150 (2005) (Pubitemid 43125082)
43. Espel E.: The role of the AU-rich elements of mRNAs in controlling translation. Semin Cell Dev Biol . 16, 59-67 (2005) (Pubitemid 40136538)
44. Kelleher R. J, III, A. Govindarajan, H. Y. Jung, H. Kang and S. Tonegawa: Translational control by MAPK signaling in long-term synaptic plasticity and memory. Cell 116, 467-479 (2004) (Pubitemid 38366322)
45. Dumitru C. D, J. D. Ceci, C. Tsatsanis, D. Kontoyiannis, K. Stamatakis, J.-H. Lin, C. Patriotis, N. A. Jenkins, N. G. Copeland, G. Kollias and P. N. Tsichlis: TNF-α induction by LPS is regulated posttranscriptionally via a Tpl2/ERK-dependent pathway. Cell 103, 1071-1083 (2000) (Pubitemid 32040907)
46. Phelps M, A. Phillips, M. Darley and J. P. Blaydes: MEK-ERK signaling controls Hdm2 oncoprotein expression by regulating hdm2 mRNA export to the cytoplasm. J Biol Chem 280, 16651-16658 (2005) (Pubitemid 41389122)
47. Habelhah H, K. Shah, L. Huang, A. Ostareck-Lederer, A. L. Burlingame, K. M. Shokat, M. W. Hentze and Z. Ronai: ERK phosphorylation drives cytoplasmic accumulation of hnRNP-K and inhibition of mRNA translation. Nat Cell Biol 3, 325-330 (2001) (Pubitemid 32201331)
48. Deleault K. M, S. J. Skinner and S. A. Brooks: Tristetraprolin regulates TNF TNF-alpha mRNA stability via a proteasome dependent mechanism involving the combined action of the ERK and p38 pathways. Mol Immunol 45, 13-24 (2008) (Pubitemid 47331659)
49. Rowlett R. M, C. A. Chrestensen, M. Nyce, M. G. Harp, J. W. Pelo, F. Cominelli, P. B. Ernst, T. T. Pizarro, T. W. Sturgill and M. T. Worthington: MNK kinases regulate multiple TLR pathways and innate proinflammatory cytokines in macrophages. Am J Physiol Gastrointest Liver Physiol epub ahead of print. (2007)
50. Andersson K. and R. Sundler: Posttranscriptional regulation of TNFalpha expression via eukaryotic initiation factor 4E (eIF4E) phosphorylation in mouse macrophages. Cytokine 33, 52-7 (2006) (Pubitemid 43220353)
51. Allemand E, S. Guil, M. Myers, J. Moscat, J. F. Caceres and A. R. Krainer: Regulation of heterogenous nuclear ribonucleoprotein A1 transport by phosphorylation in cells stressed by osmotic shock. Proc Natl Acad Sci USA 102, 3605-3610 (2005) (Pubitemid 40354658)
52. Izaurralde E, A. Jarmolowski, C. Beisel, I. W. Mattaj, G. Dreyfuss and U. Fischer: A role for the M9 transport signal of hnRNP A1 in mRNA nuclear export. J Cell Biol 137, 27-35 (1997) (Pubitemid 27167293)
53. Burd C. G. and G. Dreyfuss: RNA binding specificity of hnRNP A1: significance of hnRNP A1 high-affinity binding sites in pre-mRNA splicing. EMBO J 13, 1197-1204 (1994) (Pubitemid 24074726)
54. Yang X, M. R. Bani, S. J. Lu, S. Rowan, Y. Ben-David and B. Chabot: The A1 and A1B proteins of heterogeneous nuclear ribonucleoparticles modulate 5' splice site selection in vivo. Proc Natl Acad Sci USA 91, 6924-6928 (1994)
55. Bonnal S, F. Pileur, C. Orsini, F. Parker, F. Pujol, A. C. Prats and S. Vagner: Heterogeneous nuclear ribonucleoprotein A1 is a novel internal ribosome entry site trans-acting factor that modulates alternative initiation of translation of the fibroblast growth factor 2 mRNA. J Biol Chem 280, 4144-4153 (2005) (Pubitemid 40288579)
56. Cammas A, F. Pileur, S. Bonnal, S. M. Lewis, N. Leveque, M. Holcik and S. Vagner: Cytoplasmic Relocalization of Heterogeneous Nuclear Ribonucleoprotein A1 Controls Translation Initiation of Specific mRNAs. Mol Biol Cell 18, 5048-5059 (2007) (Pubitemid 350246704)
57. Hamilton B. J, E. Nagy, J. S. Malter, B. A. Arrick and W. F. Rigby: Association of heterogeneous nuclear ribonucleoprotein A1 and C proteins with reiterated AUUUA sequences. J Biol Chem 268, 8881-8887 (1993) (Pubitemid 23118680)
58. Hamilton B. J, C. M. Burns, R. C. Nichols and W. F. Rigby: Modulation of AUUUA response element binding by heterogeneous nuclear ribonucleoprotein A1 in human T lymphocytes. The roles of cytoplasmic location, transcription, and phosphorylation. J Biol Chem 272, 28732-28741 (1997) (Pubitemid 27517831)
59. Henics T, A. Sanfridson, B. J. Hamilton, E. Nagy and W. F. Rigby: Enhanced stability of interleukin-2 mRNA in MLA 144 cells. Possible role of cytoplasmic AU-rich sequence-binding proteins. J Biol Chem 269, 5377-5383 (1994)
60. van der Houven van Oordt, M. T. az-Meco, J. Lozano, A. R. Krainer, J. Moscat and J. F. Caceres: The MKK (3/6)-p38-signaling cascade alters the subcellular distribution of hnRNP A1 and modulates alternative splicing regulation. J Cell Biol 149, 307-316 (2000) (Pubitemid 30227149)
61. Patton J. G, E. B. Porro, J. Galceran, P. Tempst and B. Nadal-Ginard: Cloning and characterization of PSF, a novel pre-mRNA splicing factor. Genes Dev 7, 393-406 (1993) (Pubitemid 23139233)
62. Cobbold L. C, K. A. Spriggs, S. J. Haines, H. C. Dobbyn, C. Hayes, C. H. de Moor, K. S. Lilley, M. Bushell and A. E. Willis: Identification of IRES-transacting factors for the Myc family of IRESs. Mol Cell Biol 2007)
63. Zolotukhin A. S, D. Michalowski, J. Bear, S. V. Smulevitch, A. M. Traish, R. Peng, J. Patton, I. N. Shatsky and B. K. Felber: PSF acts through the human immunodeficiency virus type 1 mRNA instability elements to regulate virus expression. Mol Cell Biol 23, 6618-6630 (2003) (Pubitemid 37075772)
64. Hall-Pogar T, S. Liang, L. K. Hague and C. S. Lutz: Specific trans-acting proteins interact with auxiliary RNA polyadenylation elements in the COX-2 3'-UTR. RNA 13, 1103-1115 (2007) (Pubitemid 46984900)
65. Shav-Tal Y, M. Cohen, S. Lapter, B. Dye, J. G. Patton, J. Vandekerckhove and D. Zipori: Nuclear relocalization of the pre-mRNA splicing factor PSF during apoptosis involves hyperphosphorylation, masking of antigenic epitopes, and changes in protein interactions. Mol Biol Cell 12, 2328-2340 (2001) (Pubitemid 33051959)
66. Akhmedov A. T. and B. S. Lopez: Human 100-kDa homologous DNA-pairing protein is the splicing factor PSF and promotes DNA strand invasion. Nucleic Acids Res 28, 3022-3030 (2000) (Pubitemid 30624091)
67. Deloulme J. C, L. Prichard, O. Delattre and D. R. Storm: The prooncoprotein EWS binds calmodulin and is phosphorylated by protein kinase C through an IQ domain. J Biol Chem 272, 27369-27377 (1997) (Pubitemid 27452704)
68. Huang C. J, Z. Tang, R. J. Lin and P. W. Tucker: Phosphorylation by SR kinases regulates the binding of PTB-associated splicing factor (PSF) to the pre-mRNA polypyrimidine tract. FEBS Lett 581, 223-232 (2007) (Pubitemid 46110829)
69. Proteau A, S. Blier, A. L. Albert, S. B. Lavoie, A. M. Traish and M. Vincent: The multifunctional nuclear protein p54nrb is multiphosphorylated in mitosis and interacts with the mitotic regulator Pin1. J Mol Biol 346, 1163-1172 (2005) (Pubitemid 40215536)
70. Shav-Tal Y. and D. Zipori: PSF and p54 (nrb)/NonO-multi-functional nuclear proteins. FEBS Lett 531, 109-114 (2002) (Pubitemid 35341179)
71. Bundschu K, U. Walter and K. Schuh: The VASPSpred-Sprouty domain puzzle. J Biol Chem 281, 36477-36481 (2006)
72. Huang A. M. and G. M. Rubin: A misexpression sreen identifies genes that can modulate RAS1 pathway signaling in Drosophila melanogaster. Genetics 156, 1219-1230 (2000)
73. Chrestensen C. A, A. Eschenroeder, W. G. Ross, T. Ueda, R. Watanabe-Fukunaga, R. Fukunaga and T. W. Sturgill: Loss of MNK function sensitizes fibroblasts to serum-withdrawal induced apoptosis. Genes Cells 12, 1133-1140 (2007) (Pubitemid 47500527)
74. Chrestensen C. A, J. K. Shuman, A. Eschenroeder, M. Worthington, H. Gram and T. W. Sturgill: MNK1 and MNK2 regulation in HER2-overexpressing breast cancer lines. J Biol Chem 282, 4243-4252 (2007) (Pubitemid 47100950)
75. Baselga J.: Targeting tyrosine kinases in cancer: the second wave. Science 312, 1175-1178 (2006) (Pubitemid 43801135)
76. Wendel H. G, R. L. Silva, A. Malina, J. R. Mills, H. Zhu, T. Ueda, R. Watanabe-Fukunaga, R. Fukunaga, J. Teruya-Feldstein, J. Pelletier and S. W. Lowe: Dissecting eIF4E action in tumorigenesis. Genes Dev 21, 3232-3237 (2007) (Pubitemid 350277750)
77. Wendel H. G, E. De Stanchina, J. S. Fridman, A. Malina, S. Ray, S. Kogan, C. Cordon-Cardo, J. Pelletier and S. W. Lowe: Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy. Nature 428, 332-337 (2004) (Pubitemid 38418805)
78. Cohen N, M. Sharma, A. Kentsis, J. M. Perez, S. Strudwick and K. L. B. Borden: PML RING suppresses oncogenic transformation by reducing the affinity of eIF4E for mRNA. EMBO J 20, 4547-4559 (2001) (Pubitemid 32772048)
79. Culjkovic B, I. Topisirovic, L. Skrabanek, M. Ruiz-Gutierrez and K. L. Borden: eIF4E is a central node of an RNA regulon that governs cellular proliferation. J Cell Biol 175, 415-426 (2006) (Pubitemid 44708066)
80. Strudwick S. and K. L. Borden: The emerging roles for translation factor eIF4E in the nucleus. Differentiation 70, 10-22 (2002) (Pubitemid 38232695)
81. De Benedetti A. and J. R. Graff: eIF-4E expression and its role in malignancies and metastases. Oncogene 23, 3189-3199 (2004) (Pubitemid 38638830)
82. Lazaris-Karatzas A, K. S. Montine and N. Sonenberg: Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap. Nature 345, 544-547 (1990)
83. Smith M. R, M. Jaramillo, Y. L. Liu, T. E. Dever, W. C. Merrick and N. Sonenberg: Translation initiation factors induce DNA synthesis and transform NIH 3T3 cells. New Biol 2, 648-654 (1990) (Pubitemid 20330918)
84. Rousseau D, R. Kaspar, I. Rosenwald, L. Gehrke and N. Sonenberg: Translation initiation of ornithine decarboxylase and nucleocytoplasmic transport of cyclin D1 messenger-RNA are increased in cells overexpressing eukaryotic initiation factor 4E. Proc Natl Acad Sci USA 93, 1065-1070 (1996) (Pubitemid 26054368)
85. Culjkovic B, I. Topisirovic, L. Skrabanek, M. Ruiz-Gutierrez and K. L. Borden: eIF4E promotes nuclear export of cyclin D1 mRNAs via an element in the 3'UTR. J Cell Biol. 169, 245-256 (2005) (Pubitemid 40656563)
86. Phillips A. and J. P. Blaydes: MNK1 and EIF4E are downstream effectors of MEKs in the regulation of the nuclear export of HDM2 mRNA. Oncogene 2007)
87. Topisirovic I, M. Ruiz-Gutierrez and K. L. Borden: Phosphorylation of the eukaryotic translation initiation factor eIF4E contributes to its transformation and mRNA transport activities. Cancer Res 64, 8639-8642 (2004) (Pubitemid 39552077)
88. Kidd D. and J. W. Raff: LK6, a short-lived protein kinase in Drosophila that can associate with microtubules and centrosomes. J Cell Sci 110, 209-219 (1997) (Pubitemid 27075865)
89. Lachance P. E. D, M. Miron, B. Raught, N. Sonenberg and P. Lasko: Phosphorylation of eukaryotic translation initiation factor 4E is critical for growth. Mol Cell Biol 22, 1656-1663 (2002) (Pubitemid 34174983)
90. Parra-Palau J. L, G. C. Scheper, D. E. Harper and C. G. Proud: The Drosophila protein kinase LK6 is regulated by ERK and phosphorylates the eukaryotic initiation factor eIF4E in vivo. Biochem J 385, 695-702 (2005) (Pubitemid 40208829)
91. Arquier N, M. Bourouis, J. Colombani and P. Leopold: Drosophila Lk6 kinase controls phosphorylation of eukaryotic translation initiation factor 4E and promotes normal growth and development. Curr Biol 15, 19-23 (2005) (Pubitemid 40084697)
92. Reiling J. H, K. T. Doepfner, E. Hafen and H. Stocker: Diet-dependent effects of the Drosophila Mnk1/Mnk2 homolog Lk6 on growth via eIF4E. Curr Biol 15, 24-30 (2005) (Pubitemid 40084698)
93. Dyer J. R. and W. S. Sossin: Regulation of eukaryotic initiation factor 4E phosphorylation in the nervous system of Aplysia californica. J Neurochem 75, 872-881 (2000) (Pubitemid 30485472)
94. Dyer J. R, S. Michel, W. Lee, V. F. Castellucci, N. L. Wayne and W. S. Sossin: An activity-dependent switch to cap-independent translation triggered by eIF4E dephosphorylation. Nat Neurosci 6, 219-220 (2003) (Pubitemid 36278278)