Wnt-11 activation of a non-canonical Wnt signalling pathway is required for cardiogenesis

Nature

Volumn 418, Issue 6898, 2002, Pages 636-641

  Pandur, Petra ^a,b   Läsche, Matthias ^a   Eisenberg, Leonard M ^c   Kühl, Michael ^a,b  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b UNIVERSITY OF ULM   (Germany)

^c MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; ENZYMES; GENES;

GASTRULATION;

CARDIOLOGY;

BETA CATENIN; PROTEIN KINASE C; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; WNT PROTEIN; WNT11 PROTEIN;

BIOLOGY; SIGNALING;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; EMBRYO; EMBRYONAL CARCINOMA; ENDODERM; GASTRULATION; GENE EXPRESSION; HEART DEVELOPMENT; NONHUMAN; ORGANOGENESIS; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; XENOPUS LAEVIS;

3T3 CELLS; ANIMALS; BETA CATENIN; CULTURE MEDIA, CONDITIONED; CYTOSKELETAL PROTEINS; GLYCOPROTEINS; HEART; IN SITU HYBRIDIZATION; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; MORPHOGENESIS; MYOCARDIUM; PROTEIN KINASE C; RNA, MESSENGER; SIGNAL TRANSDUCTION; STEM CELLS; TRANS-ACTIVATORS; TUMOR CELLS, CULTURED; WNT PROTEINS; XENOPUS LAEVIS; XENOPUS PROTEINS;

ANIMALIA; MURINAE; VERTEBRATA; XENOPUS LAEVIS;

EID: 0037043688     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature00921     Document Type: Article

References (29)

1. Molecular insights into cardiac development
2. An inductive role for the endoderm in Xenopus cardiogenesis
3. XWnt-11: A maternally expressed Xenopus wnt gene
4. Spatially regulated translation in embryos: Asymmetric expression of maternal Wnt-11 along the dorsal-ventral axis in Xenopus
5. XWnt11 is a target of Xenopus Brachyury: Regulation of gastrulation movements via Dishevelled, but not through the canonical Wnt pathway
6. 2+ pathways
7. Role of frizzled 7 in the regulation of convergent extension movements during gastrulation in Xenopus laevis
8. 2+ pathway: A new vertebrate Wnt signaling pathway takes shape
9. Inhibition of Wnt activity induces heart formation from posterior mesoderm
10. Wnt antagonism initiates cardiogenesis in Xenopus laevis
11. Proteoglycans are required for maintenance of Wnt-11 expression in the ureter tips
12. Wnt-11 is expressed in early avian mesoderm and required for the differentiation of the quail mesoderm cell line QCE-6
13. WNT11 promotes cardiac tissue formation of early mesoderm
14. 2+/Calmodulin-dependent protein kinase 11 is stimulated by Wnt and Frizzled homologs and promotes ventral cell fates in Xenopus
15. XNkx-2.5, a Xenopus gene related to Nkx-2.5 and tinman: Evidence for a conserved role in cardiac development
16. Cardiac troponin 1 is a heart-specific marker in the Xenopus embryo: Expression during abnormal heart morphogenesis
17. Change in the differentiation pattern of Xenopus laevis ectoderm by variation of the incubation time and concentration of vegetalizing factor
18. Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in a G-protein-dependent manner
19. Dishevelled: At crossroads of divergent intracellular signaling pathways
20. JNK functions in the non-canonical Wnt pathway to regulate convergent extension movements in vertebrates
21. ASK1 is essential for JNK/SAPK activation by TRAF2
22. 2-terminal kinase activation in the heart
23. Activities of the wnt-1 class of secreted factors are antagonized by the wnt-5 A class and by a dominant negative cadherin in early Xenopus embryo
24. 2+ signalling
25. Functional interaction of β-catenin and the architectural transcription factor LEF-1
26. Enhanced cardiogenesis in embryonic stem cells overexpressing the GATA-4 transcription factor
27. Immunochemical analysis of myosin heavy chain during avian myogenesis in vivo and in vitro
28. A direct screen for secreted proteins in Xenopus embryos identifies distinct activities for the Wnt antagonists crescent and Frzb-1